docosahexaenoic acids

Summary

Summary: C22-unsaturated fatty acids found predominantly in FISH OILS.

Top Publications

  1. ncbi Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women
    Kevin C Maki
    Provident Clinical Research, Bloomington, IN 47403, USA Provident Clinical Research, Glen Ellyn, IL 60137, USA
    Nutr Res 29:609-15. 2009
  2. pmc Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century
    Tanya L Blasbalg
    Section on Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 93:950-62. 2011
  3. pmc Resolvin D1 binds human phagocytes with evidence for proresolving receptors
    Sriram Krishnamoorthy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:1660-5. 2010
  4. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
  5. pmc Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish
    Lucy M Browning
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom
    Am J Clin Nutr 96:748-58. 2012
  6. ncbi Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:101-37. 2007
  7. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
  8. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
  9. ncbi Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial
    Maria Makrides
    Child Nutrition Research Centre, Women s and Children s Health Research Institute, Women s and Children s Hospital, 72 King William Rd, North Adelaide SA 5006, Australia
    JAMA 304:1675-83. 2010
  10. pmc Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
    FASEB J 23:1946-57. 2009

Research Grants

  1. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
  2. ALTERED MEMBRANE PHOSPHOLIPIDS AND CARDIAC FUNCTION
    DIANE REIBEL; Fiscal Year: 1990
  3. BIOMEDICAL (BASIC)
    MIKE REUTER; Fiscal Year: 2009
  4. MECHANISMS OF RETINAL PHOTOTOXICITY
    Robert Stephens; Fiscal Year: 1992
  5. BRAIN OXIDATIVE STRESS--A SIGN OF AGING OR EMINENT DEATH
    Mostafa Badr; Fiscal Year: 2000
  6. ANTIARRHYTHMIC EFFECTS OF N-3 FATTY ACIDS
    John McAnulty; Fiscal Year: 2002
  7. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
  8. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
  9. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
  10. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007

Detail Information

Publications288 found, 100 shown here

  1. ncbi Krill oil supplementation increases plasma concentrations of eicosapentaenoic and docosahexaenoic acids in overweight and obese men and women
    Kevin C Maki
    Provident Clinical Research, Bloomington, IN 47403, USA Provident Clinical Research, Glen Ellyn, IL 60137, USA
    Nutr Res 29:609-15. 2009
    ..In conclusion, 4 weeks of krill oil supplementation increased plasma EPA and DHA and was well tolerated, with no indication of adverse effects on safety parameters...
  2. pmc Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century
    Tanya L Blasbalg
    Section on Nutritional Neuroscience, Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, USA
    Am J Clin Nutr 93:950-62. 2011
    ..The consumption of omega-3 (n-3) and omega-6 (n-6) essential fatty acids in Western diets is thought to have changed markedly during the 20th century...
  3. pmc Resolvin D1 binds human phagocytes with evidence for proresolving receptors
    Sriram Krishnamoorthy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:1660-5. 2010
    ..These results indicate that RvD1 specifically interacts with both ALX and GPR32 on phagocytes and suggest that each plays a role in resolving acute inflammation...
  4. pmc Resolvin E1 and protectin D1 activate inflammation-resolution programmes
    Jan M Schwab
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 447:869-74. 2007
    ..Together, these results identify new active components for postexudate resolution traffic, and demonstrate that RvE1 and PD1 are potent agonists for resolution of inflamed tissues...
  5. pmc Incorporation of eicosapentaenoic and docosahexaenoic acids into lipid pools when given as supplements providing doses equivalent to typical intakes of oily fish
    Lucy M Browning
    Medical Research Council Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, United Kingdom
    Am J Clin Nutr 96:748-58. 2012
    ..Estimation of the intake of oily fish at a population level is difficult. The measurement of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in biological samples may provide a useful biomarker of intake...
  6. ncbi Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 25:101-37. 2007
    ..Given the potent actions of lipoxins, resolvins, and protectins in models of human disease, deficiencies in resolution pathways may contribute to many diseases and offer exciting new potential for therapeutic control via resolution...
  7. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs...
  8. pmc Clinical correlates and heritability of erythrocyte eicosapentaenoic and docosahexaenoic acid content in the Framingham Heart Study
    William S Harris
    Sanford Research USD, 2301 E 60th St N, Sioux Falls, SD 57104, USA
    Atherosclerosis 225:425-31. 2012
    ..The objectives of this study were to define the relations between the omega-3 index and clinical factors and to determine the heritability of the omega-3 index...
  9. ncbi Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial
    Maria Makrides
    Child Nutrition Research Centre, Women s and Children s Health Research Institute, Women s and Children s Hospital, 72 King William Rd, North Adelaide SA 5006, Australia
    JAMA 304:1675-83. 2010
    ..Uncertainty about the benefits of dietary docosahexaenoic acid (DHA) for pregnant women and their children exists, despite international recommendations that pregnant women increase their DHA intakes...
  10. pmc Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
    FASEB J 23:1946-57. 2009
    ..Taken together, these findings uncover beneficial actions of omega-3-PUFAs and their bioactive lipid autacoids in preventing obesity-induced insulin resistance and hepatic steatosis...
  11. ncbi Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats
    Simon C Dyall
    Neuroscience Centre, ICMS, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, Whitechapel, London, United Kingdom
    J Neurosci Res 88:2091-102. 2010
    ..These observations illustrate additional mechanisms that might underlie the neuroprotective effects of omega-3 fatty acids in ageing...
  12. ncbi Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation
    Yee Ping Sun
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 282:9323-34. 2007
    ..These results may contribute to the beneficial actions of aspirin and omega-3 fish oils in humans...
  13. pmc Docosahexaenoic acid supplementation and cognitive decline in Alzheimer disease: a randomized trial
    Joseph F Quinn
    Department of Neurology, Oregon Health and Science University, Portland, OR 97239, USA
    JAMA 304:1903-11. 2010
    ..Epidemiological studies suggest that consumption of DHA is associated with a reduced incidence of Alzheimer disease. Animal studies demonstrate that oral intake of DHA reduces Alzheimer-like brain pathology...
  14. pmc Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model
    Frederic Calon
    Department of Medicine, University of California, Los Angeles, 90095, USA
    Neuron 43:633-45. 2004
    ..Since n-3 PFAs are essential for p85-mediated CNS insulin signaling and selective protection of postsynaptic proteins, these findings have implications for neurodegenerative diseases where synaptic loss is critical, especially AD...
  15. ncbi Resolvin D1 and its precursor docosahexaenoic acid promote resolution of adipose tissue inflammation by eliciting macrophage polarization toward an M2-like phenotype
    Esther Titos
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Center Esther Koplowitz, August Pi i Sunyer Biomedical Research Institute, 08036 Barcelona, Spain
    J Immunol 187:5408-18. 2011
    ..These findings illustrate novel mechanisms through which resolvin D1 and its precursor DHA confer anti-inflammatory and proresolving actions in inflamed adipose tissue...
  16. ncbi EPA but not DHA appears to be responsible for the efficacy of omega-3 long chain polyunsaturated fatty acid supplementation in depression: evidence from a meta-analysis of randomized controlled trials
    Julian G Martins
    Academy of Nutritional Medicine, 80 Commercial End, Swaffham Bulbeck, Cambridge CB25 0NE, UK
    J Am Coll Nutr 28:525-42. 2009
    ..However, the results of randomized controlled trials are mixed and controversy exists as to whether either eicosapentaenoic acid (EPA) or docosahexaenoic acid (DHA) or both are responsible for the reported benefits...
  17. pmc Infection regulates pro-resolving mediators that lower antibiotic requirements
    Nan Chiang
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 484:524-8. 2012
    ..These results demonstrate that specific SPMs are temporally and differentially regulated during infections and that they are anti-phlogistic, enhance containment and lower antibiotic requirements for bacterial clearance...
  18. ncbi Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    Martha Clare Morris
    Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:940-6. 2003
    ..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease...
  19. ncbi Beneficial effects of docosahexaenoic acid on cognition in age-related cognitive decline
    Karin Yurko-Mauro
    Clinical Research Department, Martek Biosciences Corporation, Columbia, MD, USA
    Alzheimers Dement 6:456-64. 2010
    ..Higher DHA intake is inversely correlated with relative risk of Alzheimer's disease. The potential benefits of DHA supplementation in age-related cognitive decline (ARCD) have not been fully examined...
  20. ncbi Docosahexaenoic acid: membrane properties of a unique fatty acid
    William Stillwell
    Department of Biology, Indiana University Purdue University Indianapolis, 723 W Michigan Street, Indianapolis, IN 46202 5132, USA
    Chem Phys Lipids 126:1-27. 2003
    ..It is concluded that DHA's interaction with other membrane lipids, particularly cholesterol, may play a prominent role in modulating the local structure and function of cell membranes...
  21. ncbi Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression
    Victor L Marcheselli
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, USA
    J Biol Chem 278:43807-17. 2003
    ..These results challenge the view that docosahexaenoate only participates in brain damage and demonstrate that this fatty acid is also the endogenous precursor to a neuroprotective signaling response to ischemia-reperfusion...
  22. pmc Distinguishing health benefits of eicosapentaenoic and docosahexaenoic acids
    Fraser D Russell
    Faculty of Science, Health, Education and Engineering, University of the Sunshine Coast, Maroochydore, Queensland 4556, Australia
    Mar Drugs 10:2535-59. 2012
    ..We suggest that there may be future opportunity to refine recommendations for intake of individual LC n-3 PUFAs...
  23. ncbi Dietary oils and FADS1-FADS2 genetic variants modulate [13C]α-linolenic acid metabolism and plasma fatty acid composition
    Leah G Gillingham
    Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, Winnipeg, Canada
    Am J Clin Nutr 97:195-207. 2013
    ..Desaturation of dietary α-linolenic acid (ALA) to omega-3 (n-3) long-chain fatty acids (FAs) is mediated through FA desaturases (FADS1-FADS2) and may be influenced by dietary FA composition...
  24. pmc Neurophysiologic and neurobehavioral evidence of beneficial effects of prenatal omega-3 fatty acid intake on memory function at school age
    Olivier Boucher
    Universite Laval, Quebec, Canada
    Am J Clin Nutr 93:1025-37. 2011
    ..However, few studies have examined the extent to which these benefits continue to be evident in childhood...
  25. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
    ..This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD...
  26. pmc Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution
    Gabrielle Fredman
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital, Harvard Institutes of Medicine and Harvard Medical School, Boston, MA 02115, USA
    Biochem J 437:185-97. 2011
    ..We also give an overview of newly described resolution circuitry whereby resolvins govern miRNAs (microRNAs), and transcription factors that counter-regulate pro-inflammatory chemokines, cytokines and lipid mediators...
  27. ncbi Alpha-linolenic acid and its conversion to longer chain n-3 fatty acids: benefits for human health and a role in maintaining tissue n-3 fatty acid levels
    Gwendolyn Barcelo-Coblijn
    Laboratory of Molecular and Cell Biomedicine, Department of Biology, Institut Universitari d Investigacio en Ciencies de la Salut, University of the Balearic Islands, Ctra de Valldemossa Km 7 5, Palma E 07122, Spain
    Prog Lipid Res 48:355-74. 2009
    ..Herein, we propose that indeed dietary ALA is a crucial dietary source of n-3 fatty acids and its dietary inclusion is critical for maintaining tissue long chain n-3 levels...
  28. pmc Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 206:15-23. 2009
    ..These findings suggest that maresins and this new metabolome may be involved in some of the beneficial actions of DHA and MPhis in tissue homeostasis, inflammation resolution, wound healing, and host defense...
  29. pmc Neuroprotectin D1: a docosahexaenoic acid-derived docosatriene protects human retinal pigment epithelial cells from oxidative stress
    Pranab K Mukherjee
    Neuroscience Center of Excellence and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 101:8491-6. 2004
    ..Because both RPE and photoreceptor cells die in retinal degenerations, our findings contribute to the understanding of retinal cell survival signaling and potentially to the development of new therapeutic strategies...
  30. ncbi The effect of omega-3 FAs on tumour angiogenesis and their therapeutic potential
    Laura Spencer
    Department of HPB and Pancreatic Surgery, Leicester General Hospital, Gwendolen Road, Leicester LE5 4PW, UK
    Eur J Cancer 45:2077-86. 2009
    ....
  31. pmc Metabolic effects of krill oil are essentially similar to those of fish oil but at lower dose of EPA and DHA, in healthy volunteers
    Stine M Ulven
    Faculty of Health, Nutrition, and Management, Akershus University College, Lillestrøm, Norway
    Lipids 46:37-46. 2011
    ..Krill oil and fish oil thus represent comparable dietary sources of n-3 PUFAs, even if the EPA + DHA dose in the krill oil was 62.8% of that in the fish oil...
  32. ncbi Distribution, interconversion, and dose response of n-3 fatty acids in humans
    Linda M Arterburn
    Martek Biosciences Corporation, Columbia, MD, USA
    Am J Clin Nutr 83:1467S-1476S. 2006
    ..We conclude that the most predictable way to increase a specific long-chain n-3 fatty acid in plasma, tissues, or human milk is to supplement with the fatty acid of interest...
  33. ncbi Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat
    Von R King
    Institute of Cell and Molecular Science, St Bartholomew s and the Royal London School of Medicine and Dentistry, Queen Mary University of London, London E1 2AT, United Kingdom
    J Neurosci 26:4672-80. 2006
    ..In contrast, the use of preparations enriched in omega-6 PUFAs after injury could worsen outcome after SCI...
  34. pmc Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis
    Matthew Spite
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 461:1287-91. 2009
    ..Together, these results identify RvD2 as a potent endogenous regulator of excessive inflammatory responses that acts via multiple cellular targets to stimulate resolution and preserve immune vigilance...
  35. pmc Resolvins RvE1 and RvD1 attenuate inflammatory pain via central and peripheral actions
    Zhen Zhong Xu
    Department of Anesthesiology, Sensory Plasticity Laboratory, Pain Research Center, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 16:592-7, 1p following 597. 2010
    ..Given the potency of resolvins and the well-known side effects of opioids and COX inhibitors, resolvins may represent new analgesics for treating inflammatory pain...
  36. pmc Low- and high-dose plant and marine (n-3) fatty acids do not affect plasma inflammatory markers in adults with metabolic syndrome
    Antonella Dewell
    Stanford Prevention Research Center and Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA
    J Nutr 141:2166-71. 2011
    ..04). In conclusion, no beneficial effects were detected for any of the 3 inflammatory markers investigated in response to (n-3) FA in adults with metabolic syndrome regardless of dose or source...
  37. ncbi Resolvins: anti-inflammatory and proresolving mediators derived from omega-3 polyunsaturated fatty acids
    Michael J Zhang
    Diabetes and Obesity Center, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Annu Rev Nutr 32:203-27. 2012
    ..In this review, we describe the endogenous biosynthesis and immunomodulatory actions of resolvins and highlight their emerging roles in health and disease...
  38. pmc MicroRNAs in resolution of acute inflammation: identification of novel resolvin D1-miRNA circuits
    Antonio Recchiuti
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital and Harvard Medical School, 77 Ave Louis Pasteur, Harvard Institutes of Medicine 829, Boston, MA 02115, USA
    FASEB J 25:544-60. 2011
    ..Taken together, these results indicate that resolvin-regulated specific miRNAs target genes involved in resolution and establish a novel resolution circuit involving RvD1 receptor-dependent regulation of specific miRNAs...
  39. pmc The precursor of resolvin D series and aspirin-triggered resolvin D1 display anti-hyperalgesic properties in adjuvant-induced arthritis in rats
    J F Lima-Garcia
    Department of Pharmacology, Centre of Biological Sciences, Universidade Federal de Santa Catarina, Florianopolis, Santa Catarina, Brazil
    Br J Pharmacol 164:278-93. 2011
    ..Here, we have investigated the possible anti-hyperalgesic effects of two lipids, aspirin-triggered resolvin D1 (AT-RvD1) and its precursor, 17(R)-hydroxy-4Z,7Z,10Z,13Z,15E,17R,19Z-docosahexaenoic acid (17(R)HDoHE)...
  40. ncbi Incorporation and clearance of omega-3 fatty acids in erythrocyte membranes and plasma phospholipids
    Jing Cao
    University of Minnesota, Minneapolis, MN 55455, USA
    Clin Chem 52:2265-72. 2006
    ..To study the effects of fatty acid supplementation, we investigated the rate of incorporation and clearance of these fatty acids in erythrocyte membranes and plasma after intake of supplements...
  41. pmc Conjunctival goblet cell secretion stimulated by leukotrienes is reduced by resolvins D1 and E1 to promote resolution of inflammation
    Darlene A Dartt
    Schepens Eye Research Institute, Harvard Medical School, Boston, MA 02114, USA
    J Immunol 186:4455-66. 2011
    ..Stimulated secretion is terminated by preventing the increase in [Ca(2+)](i) and activation of ERK1/2 by RvD1 and RvE1...
  42. ncbi Metabolic engineering of omega-3 long-chain polyunsaturated fatty acids in plants using an acyl-CoA Delta6-desaturase with omega3-preference from the marine microalga Micromonas pusilla
    James R Petrie
    Food Futures National Research Flagship, CSIRO Plant Industry, PO Box 1600, Canberra, ACT 2601, Australia
    Metab Eng 12:233-40. 2010
    ..Phylogenetic analysis indicates that this desaturase shares highly conserved motifs with previously described acyl-CoA Delta6-desaturases...
  43. pmc Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices
    S Fujita
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Br J Pharmacol 132:1417-22. 2001
    ..Linoleic acid had no effects, either. 4. These results suggest that DHA is crucial for the induction of LTP and that endogenously released DHA during tetanus is sufficient to trigger the formation of LTP...
  44. pmc Dietary supplementation with docosahexaenoic acid, but not eicosapentaenoic acid, dramatically alters cardiac mitochondrial phospholipid fatty acid composition and prevents permeability transition
    Ramzi J Khairallah
    Division of Cardiology and Department of Medicine, University of Maryland, 20 Penn Street, HSF2, Room S022, Baltimore, MD 21201, USA
    Biochim Biophys Acta 1797:1555-62. 2010
    ..In summary, dietary supplementation with DHA but not EPA, profoundly altered mitochondrial phospholipid fatty acid composition and delayed Ca2+-induced MPTP opening...
  45. ncbi A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model
    Giselle P Lim
    Department of Medicine, University of California Los Angeles, Los Angeles, California 90095, USA
    J Neurosci 25:3032-40. 2005
    ..Together, these results suggest that dietary DHA could be protective against beta-amyloid production, accumulation, and potential downstream toxicity...
  46. ncbi Conversion of alpha-linolenic acid to longer-chain polyunsaturated fatty acids in human adults
    Graham C Burdge
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Reprod Nutr Dev 45:581-97. 2005
    ..Capacity to up-regulate alphaLNA conversion in women may be important for meeting the demands of the fetus and neonate for DHA...
  47. ncbi Resolvins and protectins in the termination program of acute inflammation
    Amiram Ariel
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Boston, MA 02115, USA
    Trends Immunol 28:176-83. 2007
    ..Here, we review recent advances on the biosynthesis and actions of these novel anti-inflammatory and proresolving mediators...
  48. ncbi Omega-3 fatty acids and metabolic syndrome: effects and emerging mechanisms of action
    Hemant Poudyal
    School of Biomedical Sciences, The University of Queensland, QLD 4072, Australia
    Prog Lipid Res 50:372-87. 2011
    ....
  49. ncbi Novel fatty acid elongases and their use for the reconstitution of docosahexaenoic acid biosynthesis
    Astrid Meyer
    Biozentrum Klein Flottbek, Universitat Hamburg, D 22609 Hamburg, Germany
    J Lipid Res 45:1899-909. 2004
    ..This may be considered an encouraging first step in future efforts to implement this biosynthetic sequence into transgenic oilseed crops...
  50. pmc A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease
    Walter J Lukiw
    Louisiana State University Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, School of Medicine, New Orleans, Louisiana 70112, USA
    J Clin Invest 115:2774-83. 2005
    ..These results indicate that NPD1 promotes brain cell survival via the induction of antiapoptotic and neuroprotective gene-expression programs that suppress Abeta42-induced neurotoxicity...
  51. ncbi Docosahexaenoic acid promotes neurogenesis in vitro and in vivo
    E Kawakita
    Department of Environmental Physiology, Shimane University Faculty of Medicine, Izumo 693 8501, Japan
    Neuroscience 139:991-7. 2006
    ..These results demonstrate that docosahexaenoic acid effectively promotes neurogenesis both in vitro and in vivo, suggesting that it has the new property of modulating hippocampal function regulated by neurogenesis...
  52. ncbi Mercury, fish oils, and risk of acute coronary events and cardiovascular disease, coronary heart disease, and all-cause mortality in men in eastern Finland
    Jyrki K Virtanen
    Research Institute of Public Health, University of Kuopio, PO Box 1627, 70211 Kuopio, Finland
    Arterioscler Thromb Vasc Biol 25:228-33. 2005
    ..We investigated the effects of high mercury content in hair on the risk of acute coronary events and cardiovascular and all-cause mortality in men from eastern Finland...
  53. ncbi Is docosahexaenoic acid, an n-3 long-chain polyunsaturated fatty acid, required for development of normal brain function? An overview of evidence from cognitive and behavioral tests in humans and animals
    Joyce C McCann
    Nutrition, Metabolism and Genomics Center, Children s Hospital Oakland Research Institute, Oakland, CA 94609, USA
    Am J Clin Nutr 82:281-95. 2005
    ....
  54. ncbi Omega-3 polyunsaturated fatty acids and cardiovascular diseases
    Carl J Lavie
    Department of Cardiovascular Diseases, Ochsner Medical Center, New Orleans, LA 70121 2483, USA
    J Am Coll Cardiol 54:585-94. 2009
    ....
  55. ncbi Mechanisms of action of docosahexaenoic acid in the nervous system
    N Salem
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Lipids 36:945-59. 2001
    ..Finally, progress has been made recently in nuclear magnetic resonance studies to delineate differences in molecular structure and order in biomembranes due to subtle changes in the degree of phospholipid unsaturation...
  56. pmc Saturated-efferocytosis generates pro-resolving CD11b low macrophages: modulation by resolvins and glucocorticoids
    Sagie Schif-Zuck
    Department of Biology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel
    Eur J Immunol 41:366-79. 2011
    ..Thus, we suggest that satisfying efferocytosis generates CD11b(low) macrophages that are essential for complete nonphlogistic containment of inflammatory agents and the termination of acute inflammation...
  57. ncbi An alternative to fish oils: Metabolic engineering of oil-seed crops to produce omega-3 long chain polyunsaturated fatty acids
    Mónica Venegas-Calerón
    Department of Biological Chemistry, Rothamsted Research, Harpenden, Herts AL5 2JQ, UK
    Prog Lipid Res 49:108-19. 2010
    ..In addition, biotechnological research on the synthesis of VLC-PUFAs has provided new insights into the complexities of acyl-channelling and triacylglycerol biosynthesis in higher plants...
  58. ncbi n-3 polyunsaturated fatty acid deprivation in rats decreases frontal cortex BDNF via a p38 MAPK-dependent mechanism
    J S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Mol Psychiatry 12:36-46. 2007
    ..DHA's ability to regulate BDNF via a p38 MAPK-dependent mechanism may contribute to its therapeutic efficacy in brain diseases having disordered cell survival and neuroplasticity...
  59. ncbi The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations
    Berthold Koletzko
    Department of Pediatrics, University of Munich, Munchen, Germany
    J Perinat Med 36:5-14. 2008
    ..Dietary LC-PUFA supply should continue after the first six months of life, but currently there is not sufficient information for quantitative recommendations...
  60. ncbi n-3 PUFAs reduce VEGF expression in human colon cancer cells modulating the COX-2/PGE2 induced ERK-1 and -2 and HIF-1alpha induction pathway
    Gabriella Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, 00168 Rome, Italy
    Carcinogenesis 25:2303-10. 2004
    ..Their potential clinical application as anti-angiogenic compounds in colon cancer therapy is proposed...
  61. ncbi Fish consumption, n-3 fatty acids, and subsequent 5-y cognitive decline in elderly men: the Zutphen Elderly Study
    Boukje Maria van Gelder
    Centre for Prevention and Health Services Research, National Institute for Public Health and the Environment, Bilthoven, Netherlands
    Am J Clin Nutr 85:1142-7. 2007
    ..Indications have been seen of a protective effect of fish consumption and the intake of n-3 fatty acids on cognitive decline. However, studies are scarce and results inconsistent...
  62. pmc Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution
    Kie Kasuga
    Department of Anesthesiology, Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Immunol 181:8677-87. 2008
    ..Together, these results indicate that circulating omega-3 fatty acids rapidly appear in inflammatory sites that require conversion to resolvins that control excessive neutrophil infiltration, protect organs, and foster resolution...
  63. ncbi Dietary fat intakes for pregnant and lactating women
    Berthold Koletzko
    Dr von Hauner Children s Hospital, University of Munich, Germany
    Br J Nutr 98:873-7. 2007
    ....
  64. ncbi Omega-3 dietary supplements and the risk of cardiovascular events: a systematic review
    Paul E Marik
    Division of Pulmonary and Critical Care Medicine, Thomas Jefferson University, Philadelphia, PA 19107, USA
    Clin Cardiol 32:365-72. 2009
    ..The clinical benefit of dietary fish oil supplementation in preventing cardiovascular events in both high and low risk patients is unclear...
  65. pmc Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels
    Toshinori Hoshi
    Department of Physiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 110:4816-21. 2013
    ..This finding has practical implications for the use of omega-3 fatty acids as nutraceuticals for the general public and also for the critically ill receiving omega-3-enriched formulas...
  66. ncbi Omega-3 fatty acids in cardiac biopsies from heart transplantation patients: correlation with erythrocytes and response to supplementation
    William S Harris
    Mid America Heart Institute, Saint Luke s Hospital, Kansas City, MO, USA
    Circulation 110:1645-9. 2004
    ..The extent of incorporation has not been determined in humans...
  67. pmc Resolvin D1 limits polymorphonuclear leukocyte recruitment to inflammatory loci: receptor-dependent actions
    Lucy V Norling
    The William Harvey Research Institute, Barts and the London School of Medicine, Charterhouse Square, London EC1M 6BQ, United Kingdom
    Arterioscler Thromb Vasc Biol 32:1970-8. 2012
    ..The contribution of its specific receptors, the lipoxin A(4)/Annexin-A1 receptor formyl-peptide receptor 2 (FPR2/ALX) and the orphan receptor G-protein-coupled receptor 32 (GPR32) are of considerable interest...
  68. pmc Docosahexaenoic acid: a positive modulator of Akt signaling in neuronal survival
    Mohammed Akbar
    Section of Mass Spectrometry, Laboratory of Membrane Biochemistry and Biophysics, National Institute of Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20952 8115, USA
    Proc Natl Acad Sci U S A 102:10858-63. 2005
    ..This mechanism may contribute to neurological deficits associated with n-3 fatty acid deficiency and support protective effects of DHA in pathological models such as brain ischemia or Alzheimer's disease...
  69. ncbi Effect of low doses of long-chain n-3 PUFAs on endothelial function and arterial stiffness: a randomized controlled trial
    Thomas A B Sanders
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, London, United Kingdom
    Am J Clin Nutr 94:973-80. 2011
    ..The dietary intake of n-3 (omega-3) long-chain PUFAs (LC-PUFAs) from fish may improve endothelial function and arterial stiffness...
  70. ncbi Differential effects of eicosapentaenoic acid and docosahexaenoic acid on vascular reactivity of the forearm microcirculation in hyperlipidemic, overweight men
    T A Mori
    Department of Medicine, University of Western Australia, and The West Australian Heart Research Institute, Perth, Australia
    Circulation 102:1264-9. 2000
    ..We investigated possible differences in the effects of purified EPA or DHA on forearm vascular reactivity in overweight hyperlipidemic men that might contribute to the blood pressure-lowering effects of fish oils...
  71. ncbi Identification of a Delta 4 fatty acid desaturase from Thraustochytrium sp. involved in the biosynthesis of docosahexanoic acid by heterologous expression in Saccharomyces cerevisiae and Brassica juncea
    X Qiu
    Department of Research and Development, Bioriginal Food and Science Corporation, Saskatoon, Saskatchewan, S7J 0R1, Canada
    J Biol Chem 276:31561-6. 2001
    ..These results support the notion that DHA can be synthesized via Delta 4 desaturation and suggest the possibility that DHA can be produced in oilseed crops on a large scale...
  72. pmc Blood eicosapentaenoic and docosahexaenoic acids predict all-cause mortality in patients with stable coronary heart disease: the Heart and Soul study
    James V Pottala
    Cardiovascular Health Research Center, Sanford Research USD and Sanford School of Medicine, Sioux Falls, SD 57105, USA
    Circ Cardiovasc Qual Outcomes 3:406-12. 2010
    ..The purpose of this study was to determine the extent to which baseline blood n-3 FA levels are associated with reduced risk for all-cause mortality in patients with stable coronary heart disease...
  73. ncbi Extremely limited synthesis of long chain polyunsaturates in adults: implications for their dietary essentiality and use as supplements
    Mélanie Plourde
    Research Center on Aging, Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, 1036 Belvedere St, South, Sherbrooke, QC J1H 4C4, Canada
    Appl Physiol Nutr Metab 32:619-34. 2007
    ..Despite this inefficient conversion, there are potential roles in human health for ALA and EPA that could be independent of their metabolism to DHA through the desaturation - chain elongation pathway...
  74. pmc Arachidonic acid and the brain
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Nutr 138:2515-20. 2008
    ..8 and 4.6 mg/d, whereas in patients with Alzheimer disease, AA consumption is elevated. In the future, PET could be used to relate human brain rates of AA and DHA consumption to liver PUFA metabolism and dietary PUFA intake...
  75. ncbi Competition between 24:5n-3 and ALA for Delta 6 desaturase may limit the accumulation of DHA in HepG2 cell membranes
    Roxanne Portolesi
    Department of Paediatrics and Child Health, Flinders University, Adelaide, Australia
    J Lipid Res 48:1592-8. 2007
    ..The parallel pattern of accumulation of 24:6n-3 and DHA in response to increasing concentrations of ALA suggests that the competition between 24:5n-3 and ALA for D6D may contribute to the limited accumulation of DHA in cell membranes...
  76. ncbi Eosinophils promote resolution of acute peritonitis by producing proresolving mediators in mice
    Tomohiro Yamada
    Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    FASEB J 25:561-8. 2011
    ..The present results indicate that mouse eosinophils and eosinophil-derived lipid mediators, including PD1, have a role in promoting the resolution of acute inflammation, expanding the roles of eosinophils in host defense and resolution...
  77. pmc Incorporation of EPA and DHA into plasma phospholipids in response to different omega-3 fatty acid formulations--a comparative bioavailability study of fish oil vs. krill oil
    Jan Philipp Schuchardt
    Institute of Food Science and Human Nutrition, Leibniz University Hannover, Germany
    Lipids Health Dis 10:145. 2011
    ..Superior bioavailability has been suggested for phospholipid (PL) bound omega-3 FA in krill oil, but identical doses of different chemical forms have not been compared...
  78. pmc Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood
    Harsharan Singh Bhatia
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e28451. 2011
    ..Adequate levels of dietary DHA seem crucial for building long-term neuronal resilience for optimal brain performance and aiding in the battle against neurological disorders...
  79. ncbi Effects of highly purified eicosapentaenoic acid and docosahexaenoic acid on hemodynamics in humans
    S Grimsgaard
    Institute of Community Medicine, University of Tromsø, Norway
    Am J Clin Nutr 68:52-9. 1998
    ..We conclude that dietary DHA and EPA influence heart rate and that the fatty acid composition of plasma phospholipids may affect cardiac mechanics in humans...
  80. pmc Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium
    Ramzi J Khairallah
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 335:155-62. 2010
    ..These results show that supplementation with DHA alone effectively increases both DHA and EPA in cardiac mitochondrial phospholipids and delays MPTP and suggest that treatment with DHA + EPA offers no advantage over DHA alone...
  81. ncbi n-3 Polyunsaturated fatty acids, fatal ischemic heart disease, and nonfatal myocardial infarction in older adults: the Cardiovascular Health Study
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle 98101, USA
    Am J Clin Nutr 77:319-25. 2003
    ....
  82. ncbi Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial
    Catherine M Milte
    Nutritional Physiology Research Centre, University of South Australia, Adelaide, South Australia, Australia
    Nutrition 28:670-7. 2012
    ....
  83. ncbi Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 176:1848-59. 2006
    ..PD1 also reduced PMN infiltration after initiation (2 h) of inflammation and was additive with resolvin E1. These results indicate that PD1 is a potent stereoselective anti-inflammatory molecule...
  84. ncbi Beneficial effects of a polyunsaturated fatty acid on infant development: evidence from the inuit of arctic Quebec
    Joseph L Jacobson
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, Michigan, USA
    J Pediatr 152:356-64. 2008
    ....
  85. ncbi Lysophosphatidylcholine as a preferred carrier form of docosahexaenoic acid to the brain
    M Lagarde
    INSERM U352, Biochimie and Pharmacologie INSA Lyon, Villeurbanne, France
    J Mol Neurosci 16:201-4; discussion 215-21. 2001
    ..The results obtained allow us to raise the hypothesis that lysoPC may represent a preferred physiological carrier of DHA to the brain...
  86. pmc Syndecan-1-dependent suppression of PDK1/Akt/bad signaling by docosahexaenoic acid induces apoptosis in prostate cancer
    Yunping Hu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    Neoplasia 12:826-36. 2010
    ..The effect of DHA on PDK1/Akt/Bad signaling was abrogated by SDC-1 siRNA. These findings define a mechanism by which SDC-1-dependent suppression of phosphorylation of PDK1/Akt/Bad mediates n-3 PUFA-induced apoptosis in prostate cancer...
  87. pmc Docosahexaenoic acid signalolipidomics in nutrition: significance in aging, neuroinflammation, macular degeneration, Alzheimer's, and other neurodegenerative diseases
    Nicolas G Bazan
    Neuroscience Center of Excellence and Department of Ophthalmology, School of Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    Annu Rev Nutr 31:321-51. 2011
    ..DHA signalolipidomics in the nervous system offers emerging targets for pharmaceutical intervention and clinical translation...
  88. ncbi Maternal consumption of a docosahexaenoic acid-containing functional food during pregnancy: benefit for infant performance on problem-solving but not on recognition memory tasks at age 9 mo
    Michelle P Judge
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT, USA
    Am J Clin Nutr 85:1572-7. 2007
    ..There are few studies reporting on docosahexaenoic acid (DHA, 22:6n-3) supplementation during pregnancy and infant cognitive function. DHA supplementation in pregnancy and infant problem solving in the first year have not been investigated...
  89. ncbi Docosahexaenoic acid but not eicosapentaenoic acid lowers ambulatory blood pressure and heart rate in humans
    T A Mori
    Department of Medicine, University of Western Australia, and The West Australian Heart Research Institute, Perth, Australia
    Hypertension 34:253-60. 1999
    ..These results have important implications for human nutrition and the food industry...
  90. pmc Neurotrophins enhance retinal pigment epithelial cell survival through neuroprotectin D1 signaling
    Pranab K Mukherjee
    Neuroscience Center and Department of Ophthalmology, Louisiana State University Health Sciences Center School of Medicine, New Orleans, LA 70112, USA
    Proc Natl Acad Sci U S A 104:13152-7. 2007
    ..Taken together, these findings imply NPD1 may elicit autocrine actions on RPE cells and paracrine bioactivity in cells located in the proximity of the interphotoreceptor matrix...
  91. ncbi Maternal DHA and the development of attention in infancy and toddlerhood
    John Colombo
    Department of Psychology and The Schiefelbusch Institute for Lifespan Studies, University of Kansas, Lawrence 66045, USA
    Child Dev 75:1254-67. 2004
    ..These findings are consistent with evidence suggesting a link between DHA and cognitive development in infancy...
  92. ncbi Plasma phosphatidylcholine docosahexaenoic acid content and risk of dementia and Alzheimer disease: the Framingham Heart Study
    Ernst J Schaefer
    Lipid Metabolism Laboratory, Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging, Tuffs University, Boston, MA 02111, USA
    Arch Neurol 63:1545-50. 2006
    ..Docosahexaenoic acid (DHA) is an abundant fatty acid in the brain. In the diet, DHA is found mostly in fatty fish. The content of DHA has been shown to be decreased in the brain and plasma of patients with dementia...
  93. pmc The relationship of dietary omega-3 long-chain polyunsaturated fatty acid intake with incident age-related macular degeneration: AREDS report no. 23
    John Paul SanGiovanni
    National Eye Institute, Bethesda, Maryland, USA
    Arch Ophthalmol 126:1274-9. 2008
    ..To examine the association of dietary omega-3 long-chain polyunsaturated fatty acid and fish intake with incident neovascular age-related macular degeneration (AMD) and central geographic atrophy (CGA)...
  94. ncbi Docosahexaenoic acid induces increases in [Ca2+]i via inositol 1,4,5-triphosphate production and activates protein kinase C gamma and -delta via phosphatidylserine binding site: implication in apoptosis in U937 cells
    Virginie Aires
    Unité Propre de Recherche et de l Enseignement Supérieur, Equipe d Accueil 4183 Lipides and Signalisation Cellulaire, Faculty of Life Sciences, University of Burgundy, Dijon, France
    Mol Pharmacol 72:1545-56. 2007
    ..Our study suggests that DHA-induced activation of PLC/IP3 pathway and activation of PKCgamma/delta, via its action on PS binding site, may be involved in apoptosis in U937 cells...
  95. ncbi Dietary (n-3) fatty acids and brain development
    Sheila M Innis
    Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, BC V5Z 4H4, Canada
    J Nutr 137:855-9. 2007
    ....
  96. ncbi Docosahexaenoic acid: a natural powerful adjuvant that improves efficacy for anticancer treatment with no adverse effects
    Rafat A Siddiqui
    Cellular Biochemistry Laboratory, Indiana University Health, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    Biofactors 37:399-412. 2011
    ..Use of DHA with anticancer treatments provides an avenue to therapeutic improvement that involves less risk or side effects for patients and reduced regulatory burden for implementation...
  97. pmc Resolvin D1 prevents TNF-α-mediated disruption of salivary epithelial formation
    Olutayo Odusanwo
    Department of Oral Biology, School of Dental Medicine, University at Buffalo, The State University of New York, Buffalo, New York 14214 3092, USA
    Am J Physiol Cell Physiol 302:C1331-45. 2012
    ....
  98. pmc Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators
    Jesmond Dalli
    Center for Experimental Therapeutics and Reperfusion Injury, Harvard Institutes of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Blood 120:e60-72. 2012
    ..Moreover, they provide evidence for microparticle regulation of specific endogenous LM during defined stages of the acute inflammatory process and their dynamic changes in human primary phagocytes...
  99. ncbi The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function
    Anne Barden
    Cardiovascular Research Center, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Western Australia, Australia
    Free Radic Res 45:469-76. 2011
    ..Elevated platelet 8-F₂(t)-IsoP could limit 15-F₂(t)-IsoP-induced aggregation under conditions of oxidant stress...
  100. ncbi Allergic disease in infants up to 2 years of age in relation to plasma omega-3 fatty acids and maternal fish oil supplementation in pregnancy and lactation
    Catrin Furuhjelm
    Division of Pediatrics, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    Pediatr Allergy Immunol 22:505-14. 2011
    ..Furthermore, high proportions of DHA and EPA in maternal and infant plasma phospholipids were associated with less IgE-associated disease and a reduced severity of the allergic phenotype...
  101. ncbi Omega-3 fatty acids attenuate dendritic cell function via NF-κB independent of PPARγ
    Eve Draper
    Immunomodulation Research Group, School of Biotechnology, Dublin City University, Dublin 9, Ireland
    J Nutr Biochem 22:784-90. 2011
    ..Thus n-3 PUFA activate PPARγ and interact with NF-κB in DC. However, the anti-inflammatory effects of EPA and DHA on DCs are independent of PPARγ...

Research Grants62

  1. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..also been assigned to three new classes of autacoid lipid mediators derived from eicosapentaenoic and docosahexaenoic acids. To test our hypothesis, we propose three specific aims: " Elucidate factors responsible for cellular PDP1 ..
  2. ALTERED MEMBRANE PHOSPHOLIPIDS AND CARDIAC FUNCTION
    DIANE REIBEL; Fiscal Year: 1990
    ..e., eicosapentaenoic and docosahexaenoic acids) on platelet function and plasma lipid levels...
  3. BIOMEDICAL (BASIC)
    MIKE REUTER; Fiscal Year: 2009
    ..that estrogen stimulates the synthesis of omega-3 FAs from short-chain dietary precursors (alpha-linolenic acid) and thereby raises RBC levels of the long-chain omega-3 FAs, eicosapentaenoic and docosahexaenoic acids.
  4. MECHANISMS OF RETINAL PHOTOTOXICITY
    Robert Stephens; Fiscal Year: 1992
    ..Specific aims: to 1) quantitate hydroperoxides and aldehydes of linoleic and docosahexaenoic acids that have been identified in the retina and photoreceptor cells and extend this research to products from ..
  5. BRAIN OXIDATIVE STRESS--A SIGN OF AGING OR EMINENT DEATH
    Mostafa Badr; Fiscal Year: 2000
    ..Recently, F2-isoprostanes and F4-neuroprostanes, nonenzymatic oxidative products of arachidonic and docosahexaenoic acids, respectively, have been identified as novel and sensitive markers of oxidative injury...
  6. ANTIARRHYTHMIC EFFECTS OF N-3 FATTY ACIDS
    John McAnulty; Fiscal Year: 2002
    ..from the anti-arrhythmic properties of n-3 long chained polyunsaturated fatty acids (eicosapentaenoic and docosahexaenoic acids)...
  7. PHAGOCYTE RESOLVING METABOLISM
    Charles Serhan; Fiscal Year: 2009
    ..abstract_text> ..
  8. Phospholipid and Arachidonic Acid Signaling in Epilepsy
    Nicolas Bazan; Fiscal Year: 2007
    ..abstract_text> ..
  9. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  10. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  11. Brain DHA, Dopamine, and Behavior: Roles in ADHD
    Beth Levant; Fiscal Year: 2006
    ..Such insights may identify a means by which certain risk factors for ADHD may be reduced or eliminated or the severity of the disease may be reduced through appropriate pre- and postnatal nutrition. [unreadable] [unreadable]..
  12. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  13. LCPUFA Status and Birth Outcome in India
    JAMES BRENNA; Fiscal Year: 2007
    ..Positive results would justify an intervention studies to include LCPUFA in the diets of pregnant women in developed and developing countries. ..
  14. DIETARY ESSENTIAL FATTY ACID ACCUMULATION IN RETINA
    JAMES BRENNA; Fiscal Year: 2002
    ..Sub-normal development will be directly revealed via functional tests to assess the impact of low omega-3 fatty acid status on develop of vision acid status on development of vision and related health parameters. ..
  15. Lipidomics Session ISSFAL 2006
    JAMES BRENNA; Fiscal Year: 2006
    ..ISSFAL 2006 is expected to be among the most important international lipid metabolism conferences of the year, and a lipidomics symposium is timely given the increasing progress in this area. [unreadable] [unreadable] [unreadable]..
  16. Gas phase derivatization for lipidomic MS analysis
    JAMES BRENNA; Fiscal Year: 2007
    ....
  17. PSYCHOPHARMACOLOGICAL EFFECTS OF EXOGENOUS CHOLINE
    Richard Wurtman; Fiscal Year: 2008
    ..abstract_text> ..
  18. Development and Maintenance of Binocular Vision (EY005236)
    EILEEN ELIZABETH BIRCH; Fiscal Year: 2010
    ....
  19. PRECISE ISOTOPE RATIO CHROMATOGRAPHY AND STABLE TRACERS
    JAMES BRENNA; Fiscal Year: 2004
    ..The successful accomplishment of these plans will yield new tools and experimental approaches for investigation of the impact of developmental factors and recent physiological history on development of chronic disease. ..
  20. OMEGA-3 FATTY ACIDS IN NORMAL VISUAL DEVELOPMENT
    Eileen Birch; Fiscal Year: 2003
    ..By relating long-term outcomes to visual cortical function during infancy, we will directly evaluate the predictive of early visual tests for long-term cognitive outcomes. ..
  21. NEURAL AND ENDOCRINE REGULATION OF BRAIN AND BEHAVIOR
    Richard Wurtman; Fiscal Year: 2003
    ..abstract_text> ..
  22. Retinal Degeneration Conference
    Robert Anderson; Fiscal Year: 2004
    ..In this competitive renewal, we request funds to provide: 1) full travel awards to 25 young investigators and 1 keynote speakers, 2) some administrative expenses, and 3) modest support for all scientists who participate. ..
  23. Retinal Degeneration Conference
    Robert Anderson; Fiscal Year: 2008
    ..In this proposal, we request funds to provide: 1) full travel awards to 20 young investigators and 3 keynote speakers and 2) some administrative expenses. [unreadable] [unreadable] [unreadable]..
  24. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2003
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  25. Retinal Degeneration Conference
    Robert Anderson; Fiscal Year: 2006
    ..In this competitive renewal, we request funds to provide: 1) full travel awards to 20 young investigators and 3 keynote speakers and 2) some administrative expenses. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. EFFECTS OF BUSPIRONE IN WITHDRAWAL FROM OPIATES
    Laure Buydens Branchey; Fiscal Year: 2002
    ..Buspirone has additional advantages. It is not sedating, has no withdrawal symptoms, has no abuse potential, does not potentiate central nervous system depressants and does not induce psychomotor impairment. ..
  27. Conference--Retinal Degeneration
    Robert Anderson; Fiscal Year: 2002
    ..This is a key feature that distinguishes the International Symposium on Retinal Degenerations from other scientific meetings. ..
  28. Cholesterol and fatty acids in cocaine addiction relapse
    Laure Buydens Branchey; Fiscal Year: 2004
    ..If our preliminary findings are confirmed, the use of fatty acids supplements or changes in dietary habits could have a significant potential in the prevention of relapse in a subgroup of cocaine addicts. ..
  29. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  30. Omega-3 Fatty Acids in the Treatment of Depression
    David Mischoulon; Fiscal Year: 2005
    ..It is hoped that this project will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator. ..
  31. role of adipokines in colon epithelial cell homeostasis
    JENIFER FENTON; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  32. Omega 3 Fatty Acids & Tumor Membrane Structure/ Function
    William Stillwell; Fiscal Year: 2004
    ..These results will set the stage for creating novel methods of activating tumor-reactive CTL in vitro for the purpose of generating memory CTL to patrol for cancer cells in vivo. ..
  33. Gene Expression in Alzheimer's Disease
    Walter Lukiw; Fiscal Year: 2006
    ..abstract_text> ..
  34. Omega-3 Fatty Acids for Treatment of Major Depression
    David Mischoulon; Fiscal Year: 2010
    ..e. integrates biological findings with treatment in order to have a direct impact on the clinical practice of psychiatry. ..
  35. Brain Uptake and Utilization of Fatty Acids and Lipids
    Paul Watkins; Fiscal Year: 2004
    ..Mol. Neurosci., which has committed to publish the proceedings of the proposed meeting. ..
  36. NSAID Inhibition of Alzheimer Pathology: Role of DHA
    Gregory M Cole; Fiscal Year: 2010
    ..Understanding dietary fatty acid /Abeta-related PAK complex deficits and downstream synaptic defects will reveal a poorly studied overlap between cognitive deficits in mental retardation syndromes and AD with therapeutic implications. ..
  37. XALD: Role of Very Long Chain Fatty Acyl-CoA Synthetases
    Paul Watkins; Fiscal Year: 2006
    ..Furthermore, they will facilitate elucidation of the role of enzymes belonging to the VLACS or BG families in XALD. [unreadable] [unreadable]..
  38. Niacin, n-3 fatty acids and insulin resistance
    William Harris; Fiscal Year: 2007
    ..This should lead to more effective therapy for the dyslipidemia of insulin resistance and ultimately to reduced risk for CHD in this burgeoning patient population. ..
  39. Lipid Mediators in the Resolution of Asthma Exacerbations
    Bruce Levy; Fiscal Year: 2008
    ..This proposal's specific aims are directed towards uncovering basic mechanisms in the pathobiology of resolution from asthma exacerbation. ..
  40. RESEARCH TRAINING IN MATERNAL, INFANT & CHILD NUTRITION
    William Heird; Fiscal Year: 2008
    ..abstract_text> ..
  41. Proteomic Discovery in Parkinson-Dementia Complex of Guam
    Thomas Montine; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  42. DIETARY OMEGA-3 FATTY ACIDS, GENE EXPRESSION AND GROWTH
    William Heird; Fiscal Year: 2001
    ..abstract_text> ..
  43. Activity-Induced Recovery Following Brain Trauma
    Fernando Gomez Pinilla; Fiscal Year: 2008
    ..Therefore, the unique aspect of our proposal is to evaluate experience as a modulator of neuronal plasticity that can be used to enhance functional recovery following TBI. ..
  44. CHOLESTEROL REDUCTION EFFECTS ON BEHAVIOR
    Matthew Muldoon; Fiscal Year: 2001
    ..The use of two treatment intensities will permit examination of the dose-response relationship between the degree of cholesterol lowering and cognitive performance. ..
  45. Omega-3 fat to reduce risk for breast cancer
    WANDA ELAINE HARDMAN; Fiscal Year: 2010
    ....
  46. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  47. NOVEL LUNG DERIVED CHALONES--BIOSYNTHESIS AND BIOACTIONS
    Bruce Levy; Fiscal Year: 2002
    ..End of Abstract) ..
  48. Maternal fatty acids, birth weight and child development
    Emily Oken; Fiscal Year: 2007
    ..abstract_text> ..
  49. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  50. FATTY ACIDS AND PPARS IN BREAST CANCER PREVENTION
    Lisa Yee; Fiscal Year: 2005
    ..Yee the training required to become an independent clinician scientist in the field of preventive oncology. ..
  51. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..
  52. NEUROTROPHIN REGULATION IN THE SPINAL CORD
    Fernando Gomez Pinilla; Fiscal Year: 2003
    ..abstract_text> ..
  53. HER2/neu and dietary fat: interactions in breast cancer
    Lisa Yee; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Distress, Fish Oil, Inflammation, and Heart Disease
    Matthew Muldoon; Fiscal Year: 2006
    ..Results of the study could redirect current conceptualizations of the relationship between psychological factors and CHD risk, and lead to randomized clinical trials testing new interventions. ..
  55. Life-span extension /methionine sulfoxide reductase
    Toshinori Hoshi; Fiscal Year: 2002
    ..abstract_text> ..
  56. Novel NMDA Receptor-Binding Drugs for Ischemia/Stroke
    Yuqiang Wang; Fiscal Year: 2002
    ..PROPOSED COMMERCIAL APPLICATION: A novel drug therapy for ischemia/stroke has a substantial commercial market. ..
  57. REGULATION OF ION CHANNELS BY APOPTOSIS TRIGGER PROTEINS
    Toshinori Hoshi; Fiscal Year: 2002
    ..abstract_text> ..
  58. Impact of Development on Protein Utilization and Growth
    William Heird; Fiscal Year: 2007
    ..Overall, the findings of this project are expected to contribute to further improvements in nutritional management and, hence, outcome of LBW infants. ..
  59. PHYSICAL ACTIVITY INDUCES NEUROTROPHIC FACTORS
    Fernando Gomez Pinilla; Fiscal Year: 2002
    ..Thirdly, the PI will determine whether locomotor deficit caused by degeneration of large muscle afferents (by using high doses of pyridoxine) can be countered by daily locomotion induction of neurotrophins. ..
  60. Characterization of Dementia with Lewy Bodies: A Collaborative Study
    Thomas Montine; Fiscal Year: 2007
    ..This resource will be made available for future investigations of DLB. ..
  61. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  62. Novel Tumor-selective Anticancer Agents
    Yuqiang Wang; Fiscal Year: 2004
    ..It is expected that the novel DHA conjugates will have increased antitumor efficacies and reduced toxic side effects. ..