omega 3 fatty acids

Summary

Summary: A group of fatty acids, often of marine origin, which have the first unsaturated bond in the third position from the omega carbon. These fatty acids are believed to reduce serum triglycerides, prevent insulin resistance, improve lipid profile, prolong bleeding times, reduce platelet counts, and decrease platelet adhesiveness.

Top Publications

  1. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
  2. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  3. ncbi The importance of the ratio of omega-6/omega-3 essential fatty acids
    A P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    Biomed Pharmacother 56:365-79. 2002
  4. ncbi n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 83:1505S-1519S. 2006
  5. ncbi Blood levels of long-chain n-3 fatty acids and the risk of sudden death
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 346:1113-8. 2002
  6. ncbi Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA
    Lancet 369:578-85. 2007
  7. ncbi Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
    Marlene P Freeman
    Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
    J Clin Psychiatry 67:1954-67. 2006
  8. ncbi n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
  9. ncbi Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    Martha Clare Morris
    Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:940-6. 2003
  10. ncbi Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:2991-7. 2004

Detail Information

Publications313 found, 100 shown here

  1. ncbi Omega-3 fatty acids in inflammation and autoimmune diseases
    Artemis P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    J Am Coll Nutr 21:495-505. 2002
    ..Many of the placebo-controlled trials of fish oil in chronic inflammatory diseases reveal significant benefit, including decreased disease activity and a lowered use of anti-inflammatory drugs...
  2. ncbi Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease
    Penny M Kris-Etherton
    Circulation 106:2747-57. 2002
  3. ncbi The importance of the ratio of omega-6/omega-3 essential fatty acids
    A P Simopoulos
    The Center for Genetics, Nutrition and Health, Washington, DC 20009, USA
    Biomed Pharmacother 56:365-79. 2002
    ....
  4. ncbi n-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, United Kingdom
    Am J Clin Nutr 83:1505S-1519S. 2006
    ..The precursor n-3 PUFA alpha-linolenic acid does not appear to exert antiinflammatory effects at achievable intakes...
  5. ncbi Blood levels of long-chain n-3 fatty acids and the risk of sudden death
    Christine M Albert
    Division of Preventive Medicine, Department of Medicine, Brigham and Women s Hospital, Boston, MA 02215 1204, USA
    N Engl J Med 346:1113-8. 2002
    ..Whether long-chain n-3 fatty acids are also associated with the risk of sudden death in those without a history of cardiovascular disease is unknown...
  6. ncbi Maternal seafood consumption in pregnancy and neurodevelopmental outcomes in childhood (ALSPAC study): an observational cohort study
    Joseph R Hibbeln
    Laboratory of Membrane Biophysics and Biochemistry, US National Institute on Alcohol Abuse and Alcoholism, US National Institutes of Health, Bethesda, MD 20952, USA
    Lancet 369:578-85. 2007
    ..We used the Avon Longitudinal Study of Parents and Children (ALSPAC) to assess the possible benefits and hazards to a child's development of different levels of maternal seafood intake during pregnancy...
  7. ncbi Omega-3 fatty acids: evidence basis for treatment and future research in psychiatry
    Marlene P Freeman
    Women s Mental Health Program, Department of Psychiatry, University of Arizona College of Medicine, Tucson 85724 5002, USA
    J Clin Psychiatry 67:1954-67. 2006
    ..To determine if the available data support the use of omega-3 essential fatty acids (EFA) for clinical use in the prevention and/or treatment of psychiatric disorders...
  8. ncbi n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: a systematic review
    Chenchen Wang
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, Boston, MA, USA
    Am J Clin Nutr 84:5-17. 2006
    ..The evidence for the benefits of fish oil is stronger in secondary- than in primary-prevention settings. Adverse effects appear to be minor...
  9. ncbi Consumption of fish and n-3 fatty acids and risk of incident Alzheimer disease
    Martha Clare Morris
    Rush Institute for Healthy Aging, Department of Internal Medicine, Rush Alzheimer s Disease Center, Rush Presbyterian St Luke s Medical Center, Chicago, IL 60612, USA
    Arch Neurol 60:940-6. 2003
    ..Dietary n-3 polyunsaturated fatty acids improve brain functioning in animal studies, but there is limited study of whether this type of fat protects against Alzheimer disease...
  10. ncbi Dietary alpha-linolenic acid reduces inflammatory and lipid cardiovascular risk factors in hypercholesterolemic men and women
    Guixiang Zhao
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    J Nutr 134:2991-7. 2004
    ..05); the ALA Diet decreased HDL cholesterol and apolipoprotein AI compared with the AAD (P < 0.05). ALA appears to decrease CVD risk by inhibiting vascular inflammation and endothelial activation beyond its lipid-lowering effects...
  11. ncbi Prevention of fatal arrhythmias in high-risk subjects by fish oil n-3 fatty acid intake
    Alexander Leaf
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Circulation 112:2762-8. 2005
    ..Therefore, we hypothesized that these n-3 fatty acids might prevent potentially fatal ventricular arrhythmias in high-risk patients...
  12. ncbi Transgenic mice: fat-1 mice convert n-6 to n-3 fatty acids
    Jing X Kang
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA
    Nature 427:504. 2004
    ..As well as presenting an opportunity to investigate the roles played by n-3 fatty acids in the body, our discovery indicates that this technology might be adapted to enrich n-3 fatty acids in animal products such as meat, milk and eggs...
  13. ncbi Clinical prevention of sudden cardiac death by n-3 polyunsaturated fatty acids and mechanism of prevention of arrhythmias by n-3 fish oils
    Alexander Leaf
    Departments of Medicine, Massachusetts General Hospital, Boston, Mass, USA
    Circulation 107:2646-52. 2003
  14. ncbi Association of n-3 polyunsaturated fatty acids with stability of atherosclerotic plaques: a randomised controlled trial
    Frank Thies
    Institute of Human Nutrition, University of Southampton, Basset Crescent East, Southampton, UK
    Lancet 361:477-85. 2003
    ..We aimed to assess the hypothesis that incorporation of n-3 and n-6 PUFAs into advanced atherosclerotic plaques increases and decreases plaque stability, respectively...
  15. pmc Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1
    Makoto Arita
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 201:713-22. 2005
    ..These results demonstrate novel counterregulatory responses in inflammation initiated via RvE1 receptor activation that provide the first evidence for EPA-derived potent endogenous agonists of antiinflammation...
  16. ncbi Fish intake, contaminants, and human health: evaluating the risks and the benefits
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Mass 02115, USA
    JAMA 296:1885-99. 2006
    ..Fish (finfish or shellfish) may have health benefits and also contain contaminants, resulting in confusion over the role of fish consumption in a healthy diet...
  17. ncbi Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers
    Luigi Ferrucci
    Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Harbor Hospital, 5th Floor, 3001 Hanover Street, Baltimore, MD 21225, USA
    J Clin Endocrinol Metab 91:439-46. 2006
    ..The protective effect of PUFAs is mediated by multiple mechanisms, including their antiinflammatory properties. The association of physiological PUFA levels with pro- and antiinflammatory markers has not been established...
  18. ncbi Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology
    Robert K McNamara
    Department of Psychiatry, University of Cincinnati College of Medicine, Cincinnati, OH 45267 0559, USA
    Prostaglandins Leukot Essent Fatty Acids 75:329-49. 2006
    ....
  19. pmc Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processing
    C N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Exp Med 192:1197-204. 2000
    ..The generation of these and related compounds provides a novel mechanism(s) for the therapeutic benefits of omega-3 dietary supplementation, which may be important in inflammation, neoplasia, and vascular diseases...
  20. pmc Interplay between different polyunsaturated fatty acids and risk of coronary heart disease in men
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Mass, USA
    Circulation 111:157-64. 2005
    ..Additionally, seafood-based, long-chain n-3 PUFAs may modify the effects of plant-based, intermediate-chain n-3 PUFAs. However, the interactions of these PUFAs in relation to CHD risk are not well established...
  21. ncbi Omega-3 fatty acids as cancer chemopreventive agents
    D P Rose
    Division of Nutrition and Endocrinology, American Health Foundation, Valhalla, NY 10595, USA
    Pharmacol Ther 83:217-44. 1999
    ..Several of the known risk factors for breast, and colon cancer may be favorably modified by dietary omega-3 FA supplementation, and the implementation of clinical chemoprevention trials is now feasible...
  22. pmc Modulation of prostate cancer genetic risk by omega-3 and omega-6 fatty acids
    Isabelle M Berquin
    Department of Cancer Biology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Clin Invest 117:1866-75. 2007
    ..Our data suggest that modulation of prostate cancer development by polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. This study highlights the importance of gene-diet interactions in prostate cancer...
  23. ncbi The opposing effects of n-3 and n-6 fatty acids
    Gerd Schmitz
    Institute of Clinical Chemistry, University of Regensburg, Franz Josef Strauss Allee 11, 93042 Regensburg, Germany
    Prog Lipid Res 47:147-55. 2008
    ..In addition, the n-3/n-6 PUFA content of cell and organelle membranes, as well as membrane microdomains strongly influences membrane function and numerous cellular processes such as cell death and survival...
  24. ncbi N-3 Fatty acids for the prevention of atrial fibrillation after coronary artery bypass surgery: a randomized, controlled trial
    Leonardo Calo
    Department of Cardiac Diseases, San Filippo Neri Hospital, Rome, Italy
    J Am Coll Cardiol 45:1723-8. 2005
    ....
  25. ncbi Mechanisms of action of docosahexaenoic acid in the nervous system
    N Salem
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA
    Lipids 36:945-59. 2001
    ..Finally, progress has been made recently in nuclear magnetic resonance studies to delineate differences in molecular structure and order in biomembranes due to subtle changes in the degree of phospholipid unsaturation...
  26. ncbi Fish, omega-3 polyunsaturated fatty acids, and mortality from cardiovascular diseases in a nationwide community-based cohort of Japanese men and women the JACC (Japan Collaborative Cohort Study for Evaluation of Cancer Risk) Study
    Kazumasa Yamagishi
    Department of Public Health Medicine, Graduate School of Comprehensive Human Sciences, and Institute of Community Medicine, University of Tsukuba, Tsukuba, Japan
    J Am Coll Cardiol 52:988-96. 2008
    ....
  27. pmc Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 196:1025-37. 2002
    ..These biosynthetic pathways utilize omega-3 DHA and EPA during multicellular events in resolution to produce a family of protective compounds, i.e., resolvins, that enhance proresolution status...
  28. ncbi n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner
    Susanne Neschen
    Yale University School of Medicine, Howard Hughes Medical Institute, Departments of Internal Medicine, The Anlyan Center, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 56:1034-41. 2007
    ..0001 vs. genotype control). These data support the hypothesis that n-3 fatty acids protect from high-fat diet-induced hepatic insulin resistance in a PPAR-alpha-and diacylglycerol-dependent manner...
  29. ncbi Human requirement for N-3 polyunsaturated fatty acids
    A P Simopoulos
    The Center for Genetics Nutrition and Health, Washington, DC 20009, USA
    Poult Sci 79:961-70. 2000
    ..To obtain the recommended AI, it will be necessary to consider the issues involved in enriching the food supply with n-3 PUFA in terms of dosage, safety, and sources of n-3 fatty acids...
  30. ncbi N-3 polyunsaturated fatty acids in coronary heart disease: a meta-analysis of randomized controlled trials
    Heiner C Bucher
    Institut für Klinische Epidemiologie, Kantonsspital Basel, Basel, Switzerland
    Am J Med 112:298-304. 2002
    ..We investigated the effects of dietary and non-dietary (supplemental) intake of n-3 polyunsaturated fatty acids on coronary heart disease...
  31. pmc Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
    FASEB J 23:1946-57. 2009
    ..Taken together, these findings uncover beneficial actions of omega-3-PUFAs and their bioactive lipid autacoids in preventing obesity-induced insulin resistance and hepatic steatosis...
  32. ncbi Ratio of n-6 to n-3 fatty acids and bone mineral density in older adults: the Rancho Bernardo Study
    Lauren A Weiss
    Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Am J Clin Nutr 81:934-8. 2005
    ..Several lines of evidence suggest that n-3 fatty acids reduce the risk of some chronic diseases, including heart disease, diabetes, and cancer. Other research, mainly in animals, also suggests a role in bone health...
  33. ncbi Dietary modification of inflammation with lipids
    Philip C Calder
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, UK
    Proc Nutr Soc 61:345-58. 2002
    ..There are indications that inclusion of n-3 PUFA in enteral and parenteral formulas might be beneficial to patients in intensive care or post-surgery...
  34. pmc N-3 polyunsaturated fatty acid regulation of hepatic gene transcription
    Donald B Jump
    Department of Nutrition and Exercise Sciences, Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331 5109, USA
    Curr Opin Lipidol 19:242-7. 2008
    ..This review brings together metabolic and molecular studies that help explain n-3 (omega-3) polyunsaturated fatty acid regulation of hepatic gene transcription...
  35. ncbi Omega-3 fatty acids and coronary heart disease risk: clinical and mechanistic perspectives
    William S Harris
    Nutrition and Metabolic Disease Research, Sanford Research USD, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD 57105, USA
    Atherosclerosis 197:12-24. 2008
    ..Our focus is to review the potential mechanisms by which these fatty acids reduce cardiovascular disease risk...
  36. pmc Omega-3 fatty acids as treatments for mental illness: which disorder and which fatty acid?
    Brian M Ross
    Northern Ontario School of Medicine, Public Health Program, and Department of Chemistry, Lakehead University, Thunder Bay, Ontario, Canada
    Lipids Health Dis 6:21. 2007
    ..We have critically reviewed the double blind placebo controlled clinical trials published prior to April 2007 to determine whether omega-3 PUFA are likely to be efficacious in these disorders...
  37. ncbi Fish and long-chain omega-3 fatty acid intake and risk of coronary heart disease and total mortality in diabetic women
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
    Circulation 107:1852-7. 2003
    ....
  38. ncbi The Oxford-Durham study: a randomized, controlled trial of dietary supplementation with fatty acids in children with developmental coordination disorder
    Alexandra J Richardson
    University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, United Kingdom
    Pediatrics 115:1360-6. 2005
    ..Given the current lack of effective, evidence-based treatment options for DCD, the use of fatty acid supplements merits investigation...
  39. ncbi n-3 fatty acids, inflammation, and immunity--relevance to postsurgical and critically ill patients
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    Lipids 39:1147-61. 2004
    ..Studies to date are suggestive of clinical benefits from these approaches, especially in postsurgical patients...
  40. ncbi Significance of long-chain polyunsaturated fatty acids (PUFAs) for the development and behaviour of children
    Jan Philipp Schuchardt
    Institute of Food Science, Nutrition Physiology and Human Nutrition Unit, Leibniz University of Hanover, Am Kleinen Felde 30, 30167 Hanover, Germany
    Eur J Pediatr 169:149-64. 2010
    ..Meanwhile, several controlled studies investigated the clinical benefits of LC-PUFA supplementation in affected children and adolescents, with occasionally conflicting results...
  41. ncbi Essential fatty acids in health and chronic disease
    A P Simopoulos
    Center for Genetics, Nutrition and Health, Washington, DC 20009
    Am J Clin Nutr 70:560S-569S. 1999
    ....
  42. ncbi Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
    Ethan M Balk
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, NEMC 63, Boston, MA 02111, USA
    Atherosclerosis 189:19-30. 2006
    ..The evidence regarding the effects of omega-3 fatty acids on hs-CRP is inconclusive, as are data on ALA...
  43. ncbi (n-3) fatty acids and cancer therapy
    W Elaine Hardman
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    J Nutr 134:3427S-3430S. 2004
    ..Used alone, an (n-3) supplement may be a useful alternative therapy for patients who are not candidates for standard toxic cancer therapies...
  44. ncbi Dietary intake of fatty acids and fish in relation to cognitive performance at middle age
    S Kalmijn
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Neurology 62:275-80. 2004
    ..To examine the associations of fatty acid and fish intake with cognitive function...
  45. ncbi Impact of omega-3 fatty acid enriched TPN on leukotriene synthesis by leukocytes after major surgery
    M Koller
    Department of Surgery, BG Kliniken Bergmannsheil, Universitatsklinik, Bochum, Germany
    Clin Nutr 22:59-64. 2003
    ..Nutritive enrichment with omega-3 fatty acids in a balanced ratio with omega-6 fatty acids is an important step to avoid hyperinflammatory situations in patients after major surgery...
  46. ncbi Cognitive and physiological effects of Omega-3 polyunsaturated fatty acid supplementation in healthy subjects
    G Fontani
    University of Siena, Siena, Italy
    Eur J Clin Invest 35:691-9. 2005
    ..The aim of this study was to examine the effects of Omega-3 supplementation on some cognitive and physiological parameters in healthy subjects...
  47. ncbi Anti-obesity effects of long-chain omega-3 polyunsaturated fatty acids
    J D Buckley
    Nutritional Physiology Research Centre and Australian Technology Network ATN Centre for Metabolic Fitness, Sansom Institute for Health Research, University of South Australia, Adelaide, Australia
    Obes Rev 10:648-59. 2009
    ....
  48. ncbi Dietary long-chain n-3 fatty acids for the prevention of cancer: a review of potential mechanisms
    Susanna C Larsson
    Division of Nutritional Epidemiology, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm
    Am J Clin Nutr 79:935-45. 2004
    ..Further studies are needed to evaluate and verify these mechanisms in humans to gain more understanding of the effects of n-3 fatty acid intake on cancer risk...
  49. pmc Opposing effects of dietary n-3 and n-6 fatty acids on mammary carcinogenesis: The Singapore Chinese Health Study
    M Gago-Dominguez
    USC Norris Comprehensive Cancer Center, Keck School of Medicine of the University of Southern California, 1441 Eastlake Avenue, Los Angeles, CA 90089 9181, USA
    Br J Cancer 89:1686-92. 2003
    ..06-3.27); the corresponding RR for advanced breast cancer was 2.45 (95% CI=1.20-4.97, P for trend=0.01). To our knowledge, these are the first prospective findings linking the intake of marine n-3 fatty acids to breast cancer protection...
  50. ncbi Influence of very long-chain n-3 fatty acids on plasma markers of inflammation in middle-aged men
    Hayati M Yusof
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Prostaglandins Leukot Essent Fatty Acids 78:219-28. 2008
    ..Thus, one reason why only limited effects were seen here may be that the dose of DHA provided was insufficient...
  51. ncbi Beneficial effects of dietary omega-3 polyunsaturated fatty acid on toxin-induced neuronal degeneration in an animal model of Parkinson's disease
    M Bousquet
    Centre de recherche en endocrinologie moléculaire et oncologique, Centre hospitalier de l Universite Laval, Quebec, Canada
    FASEB J 22:1213-25. 2008
    ..05 vs. MPTP mice on control diet) in the striatum. Taken together, these data suggest that a high n-3 PUFA dietary intake exerts neuroprotective actions in an animal model of Parkinsonism...
  52. ncbi n-3 fatty acids and cardiovascular disease
    Jan L Breslow
    Rockefeller University, New York, NY 10021, USA
    Am J Clin Nutr 83:1477S-1482S. 2006
    ..3) Clinical studies to determine whether vegetable oil-derived alpha-linolenic acid added to a diet enriched in n-6 fatty acids can effectively substitute for fish oil-derived EPA plus DHA...
  53. ncbi A systemic review of the roles of n-3 fatty acids in health and disease
    Natalie D Riediger
    Department of Human Nutritional Sciences, University of Manitoba and Canadian Centre for Agri Food Research in Medicine, St Boniface Hospital Research Centre, Winnipeg, MB, Canada
    J Am Diet Assoc 109:668-79. 2009
    ....
  54. ncbi The impact of long chain n-3 polyunsaturated fatty acid supplementation on inflammation, insulin sensitivity and CVD risk in a group of overweight women with an inflammatory phenotype
    L M Browning
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge, UK
    Diabetes Obes Metab 9:70-80. 2007
    ..Inflammation is strongly related to obesity and the risk of cardiovascular disease (CVD). The metabolic benefits of long chain (LC) n-3 polyunsaturated fatty acid (PUFA) may be attributable to its anti-inflammatory properties...
  55. pmc Are all n-3 polyunsaturated fatty acids created equal?
    Breanne M Anderson
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G2W1 Canada
    Lipids Health Dis 8:33. 2009
    ..Overall, a better understanding of the individual role for ALA, EPA and DHA is needed in order to make appropriate dietary recommendations regarding n-3 polyunsaturated fatty acid consumption...
  56. ncbi Colitis-associated colon tumorigenesis is suppressed in transgenic mice rich in endogenous n-3 fatty acids
    Johannes Nowak
    Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Carcinogenesis 28:1991-5. 2007
    ..These results support a protective role of n-3 PUFA supplementation in the prevention of CRC...
  57. ncbi Long-chain n-3 fatty acids and inflammation: potential application in surgical and trauma patients
    P C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Braz J Med Biol Res 36:433-46. 2003
    ..Fish oil decreases the host metabolic response and improves survival to endotoxin in laboratory animals. Recently clinical studies performed in various patient groups have indicated benefit from this approach...
  58. pmc Omega 3 fatty acids and cardiovascular disease--fishing for a natural treatment
    Jehangir N Din
    Cardiovascular Research, University of Edinburgh, Edinburgh EH16 4SB
    BMJ 328:30-5. 2004
  59. ncbi n-3 PUFA: bioavailability and modulation of adipose tissue function
    Jan Kopecky
    Department of Adipose Tissue Biology, Institute of Physiology of the Academy of Sciences of the Czech Republic, Videnska 1083, 142 20 Prague, Czech Republic
    Proc Nutr Soc 68:361-9. 2009
    ....
  60. ncbi omega-3 Fatty acid treatment of women with borderline personality disorder: a double-blind, placebo-controlled pilot study
    Mary C Zanarini
    Laboratory for the Study of Adult Development, McLean Hospital, Belmont, MA 02478, USA
    Am J Psychiatry 160:167-9. 2003
    ..The purpose of this study was to compare the efficacy of ethyl-eicosapentaenoic acid (E-EPA) and placebo in the treatment of female subjects with borderline personality disorder...
  61. ncbi Flaxseed oil and fish-oil capsule consumption alters human red blood cell n-3 fatty acid composition: a multiple-dosing trial comparing 2 sources of n-3 fatty acid
    Gwendolyn Barcelo-Coblijn
    Department of Pharmacology, University of North Dakota, Grand Forks, ND, USA
    Am J Clin Nutr 88:801-9. 2008
    ....
  62. ncbi Nutrition in brain development and aging: role of essential fatty acids
    Ricardo Uauy
    Nutrition and Public Health Intervention Research Unit, London School of Hygiene and Tropical Medicine, United Kingdom
    Nutr Rev 64:S24-33; discussion S72-91. 2006
    ....
  63. ncbi Fish oil intake compared with olive oil intake in late pregnancy and asthma in the offspring: 16 y of registry-based follow-up from a randomized controlled trial
    Sjurdur F Olsen
    Maternal Nutrition Group, Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Am J Clin Nutr 88:167-75. 2008
    ..Evidence suggests that asthma is rooted in the intrauterine environment and that intake of marine n-3 polyunsaturated fatty acids (n-3 PUFAs) in pregnancy may have immunomodulatory effects on the child...
  64. ncbi Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
    F Thies
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 73:539-48. 2001
    ..CONCLUSION: A moderate amount of EPA but not of other n-6 or n-3 polyunsaturated fatty acids can decrease NK cell activity in healthy subjects...
  65. ncbi Dietary N-6 and N-3 polyunsaturated fatty acids and prostate cancer risk: a review of epidemiological and experimental evidence
    Pierre Astorg
    UMR U557 INSERM INRA CNAM Epidémiologie Nutritionnelle, Institut Scientifique et Technique de la Nutrition et de l Alimentation, Conservatoire National des Arts et Metiers, 5 rue du Vertbois, 75003 Paris, France
    Cancer Causes Control 15:367-86. 2004
    ..This study reviews epidemiological and experimental works dealing with the effects of dietary n -6 or n -3 polyunsaturated fatty acids (PUFA) on prostate cancer (PCa) development and PCa risk...
  66. ncbi Dietary intakes and food sources of n-6 and n-3 PUFA in French adult men and women
    Pierre Astorg
    UMR Inserm 557 INRA CNAM Epidémiologie nutritionnelle, Institut Scientifique et Technique de la Nutrition et de I Alimentatio, Conservatoire National des Arts et Metiers, Paris, France
    Lipids 39:527-35. 2004
    ..Fish and seafood consumption showed very large interindividual variations, the low consumers being at risk of insufficient n-3 PUFA intake...
  67. ncbi A quantitative risk-benefit analysis of changes in population fish consumption
    Joshua T Cohen
    Harvard Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Am J Prev Med 29:325-34. 2005
    ....
  68. ncbi Dietary fish and n-3 fatty acid intake and cardiac electrocardiographic parameters in humans
    Dariush Mozaffarian
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Am Coll Cardiol 48:478-84. 2006
    ..We evaluated the association between dietary fish intake and several cardiac electrocardiographic parameters in humans relevant to arrhythmic risk...
  69. ncbi Mechanisms for the hypotriglyceridemic effect of marine omega-3 fatty acids
    Michael H Davidson
    Radiant Research and Rush University Medical Center, Chicago, Illinois, USA
    Am J Cardiol 98:27i-33i. 2006
    ..These combined effects support the use of omega-3 fatty acids as a valuable clinical tool for the treatment of hypertriglyceridemia...
  70. ncbi Novel eicosanoid and docosanoid mediators: resolvins, docosatrienes, and neuroprotectins
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Curr Opin Clin Nutr Metab Care 8:115-21. 2005
    ..Many clinical studies suggest that omega-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid have beneficial actions in human diseases. The molecular basis of these actions remains of interest...
  71. ncbi Dietary (n-3)/(n-6) fatty acid ratio: possible relationship to premenopausal but not postmenopausal breast cancer risk in U.S. women
    Shelley L Goodstine
    Yale University School of Medicine and Yale Cancer Center, New Haven, CT, USA
    J Nutr 133:1409-14. 2003
    ..50, 95% CI 0.27, 0.95, P for trend = 0.02. These results are consistent with the hypothesis that a higher (n-3)/(n-6) PUFA ratio may reduce the risk of breast cancer, especially in premenopausal women...
  72. ncbi Fish intake is associated with a reduced progression of coronary artery atherosclerosis in postmenopausal women with coronary artery disease
    Arja T Erkkilä
    Cardiovascular Nutrition Laboratory, Jean Mayer USDA HNRCA, Tufts University, 711 Washington Street, Boston, MA 02111, USA
    Am J Clin Nutr 80:626-32. 2004
    ..However, limited data exist on the effect of fish intake on actual measures of progression of coronary artery atherosclerosis...
  73. ncbi Red cell membrane omega-3 fatty acids are decreased in nondepressed patients with social anxiety disorder
    Pnina Green
    Laboratory for the Study of Fatty Acids, Felsenstein Medical Research Center, Beilinson Campus, Petah Tiqwa, Israel
    Eur Neuropsychopharmacol 16:107-13. 2006
    ..The robust relationship between low erythrocyte n-3 PUFA concentrations and SAD justifies exploration of relevant neuropathophysiological mechanisms...
  74. ncbi Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women
    Esther Lopez-Garcia
    Department of Nutrition, Harvard School of Public Health, Harvard Medical School, USA
    J Nutr 134:1806-11. 2004
    ....
  75. pmc Risks and benefits of omega 3 fats for mortality, cardiovascular disease, and cancer: systematic review
    Lee Hooper
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich NR4 7TJ
    BMJ 332:752-60. 2006
    To review systematically the evidence for an effect of long chain and shorter chain omega 3 fatty acids on total mortality, cardiovascular events, and cancer.
  76. pmc Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
    Christian A Hudert
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11276-81. 2006
    ..They add insight into the molecular mechanisms of inflammation protection afforded by n-3 PUFA through formation of resolvins and protectins other than inhibition of n-6 PUFA-derived eicosanoid formation...
  77. ncbi Omega-3 fatty acid prevents heart rate variability reductions associated with particulate matter
    Isabelle Romieu
    Instituto Nacional de Salud Publica, Cuernavaca, Mexico
    Am J Respir Crit Care Med 172:1534-40. 2005
    ..Environmental exposure to particulate matter of 2.5 microm or less (PM2.5) has been associated with changes in heart rate variability (HRV)...
  78. ncbi Increasing the amount of n-3 fatty acid in meat from young Holstein bulls through nutrition
    N Mach
    Animal Nutrition, Management, and Welfare Group, Unitat de Remugants IRTA, Barcelona, 08193, Spain
    J Anim Sci 84:3039-48. 2006
    ..2 mg/kg of LM, respectively). Concentration of n-3 fatty acids in meat of bulls fed high-concentrate diets can be enhanced by whole linseed supplementation without affecting animal performance, ruminal fermentation, or carcass quality...
  79. ncbi Fish consumption and depression: the Northern Finland 1966 birth cohort study
    Markku Timonen
    Department of Public Health Science and General Practice, University of Oulu, Box 5000, FIN 90014 Oulu, Finland
    J Affect Disord 82:447-52. 2004
    ....
  80. ncbi Neuroprotective action of omega-3 polyunsaturated fatty acids against neurodegenerative diseases: evidence from animal studies
    Frederic Calon
    Molecular Endocrinology and Oncology Research Centre, Centre Hospitalier de l Université Laval Research Centre CHUL, 2705 Laurier Blvd, Quebec, Canada
    Prostaglandins Leukot Essent Fatty Acids 77:287-93. 2007
    ....
  81. pmc Omega 3 fatty acids reduce myeloid progenitor cell frequency in the bone marrow of mice and promote progenitor cell differentiation
    Melinda E Varney
    Department of Biochemistry and Microbiology, Marshall University School of Medicine, Huntington, WV 25755, USA
    Lipids Health Dis 8:9. 2009
    b>Omega 3 fatty acids have been found to inhibit proliferation, induce apoptosis, and promote differentiation in various cell types...
  82. ncbi The potential for treatment with dietary long-chain polyunsaturated n-3 fatty acids during chemotherapy
    Patricia D Biondo
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
    J Nutr Biochem 19:787-96. 2008
    ....
  83. ncbi Very low n-3 long-chain polyunsaturated fatty acid status in Austrian vegetarians and vegans
    Margit Kornsteiner
    Department of Nutritional Sciences, Faculty of Life Sciences, University of Vienna, Vienna, Austria
    Ann Nutr Metab 52:37-47. 2008
    ....
  84. ncbi A prospective study of intake of fish and marine fatty acids and prostate cancer
    Katarina Augustsson
    Department of Nutrition, Harvard School of Public Health, Harvard Medical School, Boston, Massachusetts, USA
    Cancer Epidemiol Biomarkers Prev 12:64-7. 2003
    ..We found that men with high consumption of fish had a lower risk of prostate cancer, especially for metastatic cancer. Marine fatty acids may account for part of the effect, but other factors in fish may also play a role...
  85. ncbi Fatty acids and postprandial inflammation
    Andrew N Margioris
    Department of Clinical Chemistry, School of Medicine, University of Crete, Crete, Greece
    Curr Opin Clin Nutr Metab Care 12:129-37. 2009
    ..Purpose of this review is to describe this exciting new area of research and its repercussions in the way we, the consumers, and the food industry evaluate the type and quantity of fat in food...
  86. ncbi C-reactive protein, dietary n-3 fatty acids, and the extent of coronary artery disease
    T Madsen
    Department of Cardiology, Aalborg Hospital, Aalborg, Denmark
    Am J Cardiol 88:1139-42. 2001
    ....
  87. ncbi A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain
    Robert J Goldberg
    Department of Psychology, York University, Toronto, ON, Canada
    Pain 129:210-23. 2007
    ..15; 95% CI: -0.19 to 0.49, p=0.40) at 3-4 months. The results suggest that omega-3 PUFAs are an attractive adjunctive treatment for joint pain associated with rheumatoid arthritis, inflammatory bowel disease, and dysmenorrhea...
  88. pmc Lipid peroxidation and oxidant stress regulate hepatic apolipoprotein B degradation and VLDL production
    Meihui Pan
    The Zena and Michael A Wiener Cardiovascular Institute and the Department of Medicine, Mount Sinai School of Medicine, New York, New York, USA
    J Clin Invest 113:1277-87. 2004
    ....
  89. ncbi Diet and asthma
    Tricia M McKeever
    Division of Epidemiology and Public Health, University of Nottingham, City Hospital, Nottingham NG5 1PB, UK
    Am J Respir Crit Care Med 170:725-9. 2004
  90. ncbi n-3 long-chain polyunsaturated fatty acids in type 2 diabetes: a review
    Joyce A Nettleton
    ScienceVoice Consulting, Denver, CO 80205, USA
    J Am Diet Assoc 105:428-40. 2005
    ..Expected health benefits and public health implications of consuming 1 to 2 g/day n-3 LC-PUFA as part of lifestyle modification in insulin resistance and type 2 diabetes are discussed...
  91. ncbi Dietary intake of folate, other B vitamins, and omega-3 polyunsaturated fatty acids in relation to depressive symptoms in Japanese adults
    Kentaro Murakami
    Department of Epidemiology and International Health, Research Institute, International Medical Center of Japan, Tokyo, Japan
    Nutrition 24:140-7. 2008
    ..We examined cross-sectional associations between the intake of folate, other B vitamins, and omega-3 PUFAs and depressive symptoms in Japanese adults...
  92. ncbi Fish consumption, n-3 fatty acids, and colorectal cancer: a meta-analysis of prospective cohort studies
    Anouk Geelen
    Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands
    Am J Epidemiol 166:1116-25. 2007
    ..Existing evidence that n-3 fatty acids inhibit colorectal carcinogenesis is in line with these results, but few data are available addressing this association...
  93. ncbi Anti-inflammatory properties of omega-3 fatty acids in critical illness: novel mechanisms and an integrative perspective
    Pierre Singer
    Department of General Intensive Care, Institute for Nutrition Research, Petach Tikva, Israel
    Intensive Care Med 34:1580-92. 2008
    ..Regulation of the activity of transcription factor NF-kappaB is an important therapeutic effect of the major omega-3 fatty acids in fish oil, eicosapentaenoic and docosahexaenoic acid (EPA and DHA)...
  94. ncbi n-3 fatty acids and gene expression
    Richard J Deckelbaum
    Institute of Human Nutrition, The Department of Pediatrics, College of Physicians and Surgeons of Columbia University, New York, NY 10032, USA
    Am J Clin Nutr 83:1520S-1525S. 2006
    ..Modulation of specific genes by n-3 fatty acids and cross-talk between these genes are responsible for many effects of n-3 fatty acids...
  95. ncbi Modulation of omega-3/omega-6 polyunsaturated ratios with dietary fish oils in men with prostate cancer
    W J Aronson
    Department of Urology, University of California, Los Angeles, School of Medicine, Los Angeles, California 90095-1738, USA
    Urology 58:283-8. 2001
    ..The potential for this diet to prevent the development and progression of prostate cancer by way of altered COX-2 expression and prostaglandin production in prostatic tissue requires further study...
  96. ncbi Omega 3 fatty acids and the brain: review of studies in depression
    Andrew J Sinclair
    School of Exercise and Nutrition Sciences, Deakin University, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Asia Pac J Clin Nutr 16:391-7. 2007
    ..It is clear from the literature that DHA is involved in a variety of processes in neural cells and that its role is far more complex than simply influencing cell membrane properties...
  97. pmc Higher dietary intake of long-chain omega-3 polyunsaturated fatty acids is inversely associated with depressive symptoms in women
    Laura A Colangelo
    Department of Preventive Medicine, Feinberg School of Medicine, Chicago, Illinois, USA
    Nutrition 25:1011-9. 2009
    ....
  98. ncbi The role of dietary n-6 and n-3 fatty acids in the developing brain
    S M Innis
    Department of Paediatrics, University of British Columbia, Vancouver, B C, Canada
    Dev Neurosci 22:474-80. 2000
    ..These findings should guide clinical studies to more sensitive measures of the functional roles of dietary n-3 fatty acids and to clinical conditions where n-3 fatty acids may have benefit...
  99. ncbi alpha-Linolenic acid supplementation and conversion to n-3 long-chain polyunsaturated fatty acids in humans
    J Thomas Brenna
    Division of Nutritional Sciences, Cornell University, Savage Hall, Ithaca, NY 14853, USA
    Prostaglandins Leukot Essent Fatty Acids 80:85-91. 2009
    ..With no other changes in diet, improvement of blood DHA status can be achieved with dietary supplements of preformed DHA, but not with supplementation of ALA, EPA, or other precursors...
  100. ncbi Essential fatty acids and the brain
    Marianne Haag
    Department of Physiology, University of Pretoria, PO Box 2034, Pretoria 0001, South Africa
    Can J Psychiatry 48:195-203. 2003
    ..To review the role of essential fatty acids in brain membrane function and in the genesis of psychiatric disease...
  101. ncbi Omega-3 polyunsaturated fatty acids and skeletal health
    B A Watkins
    Department of Food Science, Lipid Chemistry and Molecular Biology Laboratory, Purdue University, West Lafayette, Indiana 47907, USA
    Exp Biol Med (Maywood) 226:485-97. 2001
    ....

Research Grants73

  1. INSULIN RECEPTORS AND THE GLUCOSE TRANSPORT SYSTEM
    JERROLD MICHAEL OLEFSKY; Fiscal Year: 2013
    ..b>Omega 3 fatty acids are potent anti-inflammatory mole- cules and our studies show that these anti-inflammatory effects are ..
  2. Mechanism of action of omega-3 fatty acids in brain injury
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2010
    ....
  3. Lung VITamin D and OmegA-3 TriaL (Lung VITAL)
    Diane R Gold; Fiscal Year: 2013
    ..If vitamin D or marine omega-3 fatty acid supplementation reduce COPD and asthma exacerbations, reduce decline of lung function, improve asthma control and/or reduce pneumonia risk, this would be of great benefit to public health. ..
  4. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..Favorable outcomes from this study could translate into a new approach to improve heart disease risk in men and women with the metabolic syndrome. ..
  5. Vitamin D and Fish Oil for Autoimmune Disease, Inflammation and Joint Pain
    Karen H Costenbader; Fiscal Year: 2013
    ....
  6. VITamin D and OmegA-3 TriaL: Effects on Bone Structure and Architecture
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ..Findings from this proposal will fill gaps in knowledge and inform clinical and public health recommendations. ..
  7. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ....
  8. Effects of Vitamin D and Marine Omega-3 Fatty Acids on Anemia in the Elderly
    Nancy Berliner; Fiscal Year: 2013
    ..abstract_text> ..
  9. Omega 3 Fatty Acid Supplementation in Diabetic Kidney Disease
    EDGAR RAYMOND MILLER; Fiscal Year: 2010
    ..We are hopeful that omega-3 fatty acid supplements may add to current therapies that help protect against progression of kidney disease, a common and devastating complication of diabetes. ..
  10. Omega-3 Fatty Acids, Neurohumoral Activation, and Human Heart Failure
    Kevin D Monahan; Fiscal Year: 2010
    ..The novel studies outlined in this application will provide unique insight into the therapeutic potential of omega-3 fatty acid supplementation in the management of patients with heart failure. ..
  11. Nutrition Intervention to Reduce Symptoms in Patients with Advanced Heart Failure
    Terry A Lennie; Fiscal Year: 2013
    ..Patients will be followed for an additional 6 months by telephone to collect longer term data on symptom burden and quality of life as well as heart failure hospitalization and all-cause mortality at 9 and 12 months. ..
  12. Obesity and Asthma: Genetics and Nutrigenetic Response to Omega-3 Fatty Acids
    Jason E Lang; Fiscal Year: 2013
    ..This project, through our ALA-ACRC affiliation, may be well positioned to transition into a large multicenter asthma trial. ..
  13. Vitamin D and Omega-3 Fatty Acids(VITAL Trial): Effects on Fractures
    MERYL SUSAN LEBOFF; Fiscal Year: 2013
    ....
  14. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Childhood Depression
    Mary A Fristad; Fiscal Year: 2013
    ....
  15. Gut mucosal mast cells are activated by fat absorption: physiology and mechanism
    Patrick Tso; Fiscal Year: 2013
    ..the MMCs and that the order of potency is omega 6 (linoleate &arachidonate) >omega 9 (oleate) >omega 3 fatty acids (linolenate). To test these hypotheses, we proposed the following studies: Specific Aim 1...
  16. Randomized trial of vitamin D and omega-3 fatty acids for diabetic kidney disease
    Ian H De Boer; Fiscal Year: 2013
    ..This study will evaluate whether vitamin D3 and/or omega-3 fatty acids are safe and effective interventions to reduce the burden of DKD among the large and growing diabetic population. ..
  17. A Large Randomized Trial of Vitamin D, Omega-3 Fatty Acids and Cognitive Decline
    Jae H Kang; Fiscal Year: 2013
    ..We propose an exciting substudy, incorporating cognitive testing among VITAL participants aged 65+ years to evaluate whether marine omega-3 fatty and vitamin D may be important in the maintenance of cognitive function in men and women. ..
  18. Omega-3 Fatty Acid Administration In Dialysis Patients
    Talat Alp Ikizler; Fiscal Year: 2010
    ..We propose to test if reducing inflammation with an anti-inflammatory treatment (Omega-3 fatty acids in this case) will reduce inflammation and muscle loss in dialysis patients. ..
  19. Therapeutic Efficacy of Flaxseed in the Treatment of Ovarian Cancer
    Dale B Hales; Fiscal Year: 2013
    ....
  20. Long-Chain Fatty Acids, Oxidative Stress and Colorectal Neoplasm Risk
    Harvey J Murff; Fiscal Year: 2013
    ..The purpose of this study is to determine if omega-3 fatty acids reduce the risk of colorectal adenomas and diminishes the production of inflammatory and oxidative stress biomarkers. ..
  21. VITAL-DEP: Depression Endpoint Prevention in the VITamin D and OmegA-3 TriaL
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2013
    ....
  22. KLF2, monocyte activation and vascular inflammation
    MUKESH KUMAR JAIN; Fiscal Year: 2013
    ..The results of these studies may also provide the foundation for novel therapies directed at the treatment of a broad spectrum of chronic inflammatory disorders. ..
  23. Energetics &Breast Cancer: Obesity, Inflammation, Insulin Resistance &Risk
    Ruth E Patterson; Fiscal Year: 2013
    ..mouse models to investigate whether the beneficial anti-inflammatory and insulin-sensitizing effects of omega 3 fatty acids will reduce breast tumor growth and metastasis and whether the w3 fatty acid receptor GPR120 is the ..
  24. Stress, Mood, Omega-3 Fatty Acids, &Telomeric Aging: Randomized Controlled Trial
    Janice K Kiecolt-Glaser; Fiscal Year: 2012
    ..By adding cell aging assessments to an ongoing randomized controlled trial of omega-3 supplementation, we can assess how omega-3 supplementation affects both telomerase activity and telomere length, as well as possible mechanisms. ..
  25. Red Blood Cell Omega-3 Fatty Acids and Coronary Artery Disease
    Luc Djousse; Fiscal Year: 2010
    ..Findings of this study may provide important information that could shape dietary recommendations to prevent coronary events. ..
  26. Role of IGF-1R in breast cancer proliferation and survival via CYP1A1 epoxygenase
    MARIANGELLYS RODRIGUEZ; Fiscal Year: 2012
    ..The results will advance the breast cancer field by characterizing the biological mechanism by which the metabolism of dietary omega-3 fatty acids is regulated by insulin-like growth factors to promote the growth of breast cancer. ..
  27. VITamin D and omegA-3 triaL (VITAL)
    JOANN ELISABETH MANSON; Fiscal Year: 2013
    ..Findings from this large clinical trial will clarify the role of vitamin D and marine omega-3 fatty acid supplements in the primary prevention of cancer and cardiovascular disease in men and women. ..
  28. ENALS IN TUMORIGENESIS
    Fung Lung Chung; Fiscal Year: 2010
    ..These studies will provide insight into the significance of cyclic dG modifications as a class of endogenous DNA lesions in apoptosis and shed light on the mechanisms by which omega-3 fatty acids protect against colon carcinogenesis. ..
  29. Effects of Dietary Omega-3 Fatty Acids on Akt Signaling in Prostate Cancer
    Yong Q Chen; Fiscal Year: 2013
    ..If our hypothesis is correct, the successful completion of the proposed work will demonstrate, for the first time, the role of dietary fatty acids in regulating PIP formation and Akt function. ..
  30. Use or Metabolomic Markers of Response to Fish Oil Supplementation to Identify Ef
    CHARLES BOLT STEPHENSEN; Fiscal Year: 2011
    ..In this study we will develop and evaluate biomarkers of response to intake of fish oil supplements that will improve our ability to evaluate the impact of such interventions on inflammation and risk of chronic inflammatory disease. ..
  31. Effects of vitamin D and omega-3 fatty acids on infectious diseases and hCAP18
    Carlos A Camargo; Fiscal Year: 2013
    ..The findings may have direct clinical and public health impact for the prevention of infections in older adults. ..
  32. Cholestasis Reversal (Phase ll): Efficacy of lV Fish Oil
    Mark Puder; Fiscal Year: 2010
    ..Although the proposed study is not a randomized trial, it is thought that sufficient evidence could be generated that would result in FDA approval of an lFE such as Omegaven. ..
  33. Neuroimaging of Fatty Acids in Major Depression
    M Elizabeth Sublette; Fiscal Year: 2012
    ..This study is expected to contribute to understanding the neurobiology of depression and may provide new information relevant to treatment with dietary fatty acids. ..
  34. The Role of GPR120 and Omega-3 Fatty Acids in Steatosis and Systemic Inflammation
    Sarah Carlson; Fiscal Year: 2013
    ..Markers of insulin resistance, peripheral fat inflammation and liver injury will be compared between groups. ..
  35. Reducing Dyskinesia in Parkinson Disease with Omega-3 Fatty Acids
    KATHRYN ANNE CHUNG; Fiscal Year: 2012
    ..Trends in dyskinesia development may be measured. This will provide the needed background information to proceed with a future larger trial of DHA to prevent dyskinesia in PD. ..
  36. VITAL-AMD: Prevention of AMD in the VITamin D and OmegA-3 Trial
    Debra A Schaumberg; Fiscal Year: 2013
    ..Findings from this large clinical trial will clarify the role of vitamin D and omega-3 fatty acid supplements in he prevention of AMD, the leading cause of blindness in US men and women. ..
  37. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2013
    ....
  38. Echium Oil Modulates Macrophage Inflammation by Promoting Alternative Activation
    AMANDA WIBLEY; Fiscal Year: 2010
    ....
  39. Omega-3 Fatty Acids for Prevention of Dry Eye Disease: VITAL-DED
    Debra A Schaumberg; Fiscal Year: 2013
    ....
  40. Nutritional Components of Psychiatric Disease and Treatment Response
    Simon J Evans; Fiscal Year: 2013
    ..I will emerge from this training as a competitive clinical researcher in a field that has a significant potential to impact current psychiatric practice by understanding complex dietary factors that influence mental health and disease. ..
  41. Fish oil for the prevention and treatment of ovarian cancer
    Dale B Hales; Fiscal Year: 2012
    ....
  42. Maternal Methylmercury Exposure Through Rice Ingestion and Offspring Development
    SARAH ROTHENBERG; Fiscal Year: 2013
    ....
  43. Restoration of Homeostasis After Brain Trauma
    Fernando Gomez-Pinilla; Fiscal Year: 2013
    ....
  44. Controlling cancer with aspirin-triggered stimulation of resolution
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2013
    ....
  45. Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's Disease
    Gregory M Cole; Fiscal Year: 2013
    ....
  46. Effect of Vitamin D and Omega-3 Fatty Acids on Blood Pressure and Hypertension
    Howard D Sesso; Fiscal Year: 2013
    ..Because high blood pressure is responsible for one out of every six deaths in the United States, the results of this study could possibly improve the health of many people. ..
  47. BIOBEHAVIORAL STUDIES OF CARDIOVASCULAR DISEASE
    Stephen B Manuck; Fiscal Year: 2012
    ..abstract_text> ..
  48. Lipoic Acid and Omega-3 Fatty Acids in Alzheimer's Disease
    LYNNE H SHINTO; Fiscal Year: 2012
    ..S. and little is know about the safety and effectiveness of many of these therapies, it is an important public health issue to scientifically evaluate these therapies. ..
  49. A platform for individualized nutritional therapy in Alzheimer's disease
    Gene L Bowman; Fiscal Year: 2012
    ..homocysteine and its determinants, antioxidants and F2 Isoprostanes as a marker of oxidative stress, the omega 3 fatty acids docosahexaenoic acid and eicosapentaenoic acid, and cholesterol...
  50. Alternative treatments for disc degeneration: Effects on matrix homeostasis
    Gwendolyn A Sowa; Fiscal Year: 2013
    ..The goals of this research are to understand the effects of motion based therapies, such as yoga, and oral supplements, including glusosamine, chondroitin, and omega-3 fatty acids, on the cartilage of the spine. ..
  51. Endogenous Anti-Inflammatory Lipid Mediators, Fish Oil and Post-Operative Atrial
    Dariush Mozaffarian; Fiscal Year: 2013
    ..placebo, on these MEFAs response;and the relationship of MEFAs levels with POAF. ..
  52. Effect of Omega-3 Fatty Acids on Cancer Stem Cells
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2013
    ..Our long-term goal is to understand the health benefits of bioactive metabolites of ?-3 fatty acids and translate these findings in CML patients. ..
  53. Effect of dietary omega 3 fatty acids on colitis and colon cancer development in
    JENIFER IMIG FENTON; Fiscal Year: 2012
    ..This research will also contribute to the basic understanding of how susceptible models can inform the risks associated with dietary supplementation and potential risk/benefit for future human studies. ..
  54. Omega-3 Fatty Acids &Psychoeducational Psychotherapy for Child Bipolar NOS
    Mary A Fristad; Fiscal Year: 2013
    ..This pilot study of ?3, PEP, and combined treatment will provide evidence about whether a larger trial is feasible and justified. ..
  55. Detecting Which Patients With Schizophrenia Will Improve With Omega 3 Treatment
    Philip R Szeszko; Fiscal Year: 2013
    ..Confirmation of our hypothesis will provide the data required to design a more definitive omega-3 trial using a targeted patient approach with the long-term goal of determining which patients can benefit from omega-3 treatment. ..
  56. Neutrophils and Periodontitis in Diabetes
    Thomas E Van Dyke; Fiscal Year: 2013
    ..In this proposal, we will investigate the mechanism of action of phagocyte interactions in the periodontium invoking innate antimicrobial activity and enhanced clearance of pathogens in people with diabetes. ..
  57. The influence of pricing and nutrient profiling on food purchases
    Leonard H Epstein; Fiscal Year: 2013
    ..foods on a 1-100 scale based on an algorithm that takes in to account positive (fiber, vitamins, minerals, Omega 3 fatty acids, etc...
  58. Fish oil and neurovascular control in humans
    Jason Carter; Fiscal Year: 2009
    ..This project will provide new knowledge regarding the effect of fish oil on neurovascular control in both normotensive and hypertensive humans. ..
  59. Resolution of chemotherapy-induced peripheral neuropathy by novel lipid mediator
    Zhen Zhong Xu; Fiscal Year: 2013
    ..We believe this application will demonstrate novel molecular and cellular mechanisms of CIPN and help develop new therapy for treating chronic pain associated with CIPN. ..
  60. DIETARY LIPIDS--EFFECTS ON LIPID-LIPOPROTEIN METABOLISM
    D Illingworth; Fiscal Year: 1991
    ..Overall, these studies should enhance our knowledge concerning the clinical and metabolic effects of specific dietary lipids and have direct therapeutic application to treatment of subjects with hypercholesterolemia...
  61. EFFECTS OF OMEGA-3 FATTY ACIDS ON COGNITIVE PERFORMANCE
    Matthew F Muldoon; Fiscal Year: 2012
    ..Since some evidence links low intake with poor cognitive function, the planned research would test whether taking a supplement of omega-3 fatty acids improves mental speed, information processing, and memory. ..
  62. Ancillary: Inflammation/Oxidation, Omega-3's, & Post-Op AFiB & Cognitive Decline
    Dariush Mozaffarian; Fiscal Year: 2010
    ..End of Abstract) ..
  63. Pilot Study on Mammary Expression of Novel Desaturases
    ALISON VAN EENENNAAM; Fiscal Year: 2005
    ....
  64. DIETARY OMEGA-3 FATTY ACIDS, GENE EXPRESSION AND GROWTH
    William Heird; Fiscal Year: 2001
    ..abstract_text> ..
  65. Cholestasis Prevention: Efficacy of IV Fish Oil
    Mark Puder; Fiscal Year: 2009
    ..Use of PN with fish oil base emulsion may prevent liver dysfunction resulting generally in better heath outcomes for these children. ..
  66. OMEGA-3 FATTY ACIDS AND THE CEREBRAL CIRCULATION
    EARL ELLIS; Fiscal Year: 1993
    ..The proposed aims are consistent with our long term goal of understanding how polyunsaturated fatty acids affect brain function and brain blood flow...
  67. EFFECTS OF POLYUNSATURATED FATTY ACIDS ON MEGAKARYOCYTES
    PAUL SCHICK; Fiscal Year: 1991
    ..The goals of the study are to determine the effects of omega 3 fatty acids, eicosapentaenoic and docosahexaenoic, and alpha linolenic acid, as well as the omega 6 fatty acids, ..
  68. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    ..The significance of this research is that the results may provide potentially useful information concerning the dietary management of CHD...
  69. FISH OILS AND LIPOPROTEIN METABOLISM
    William Harris; Fiscal Year: 1992
    ..These studies should reveal the mechanisms by which w3 FA supplements alter lipoprotein metabolism in HTG patients...
  70. Nutrition Intervention: Metabolic Complications of HIV+
    Margo Woods; Fiscal Year: 2006
    ..A 6-month follow-up will then remeasure all the study parameters to determine if the nutrition intervention group had experienced an improvement of the listed risk factors compared to the control group. ..
  71. Postpartum Depression: Omega-3 FA vs Placebo
    Marlene Freeman; Fiscal Year: 2006
    ..These doses should provide an adequate test of the efficacy of omega-3 fatty acids while being safe for the mother and breastfeeding baby. ..
  72. NMU INDUCED MAMMARY CANCER AND OMEGA 3 FATTY ACIDS
    Leonard Cohen; Fiscal Year: 1990
    ..The ultimate objective of this proposal is the development of an optimal omega-6/omega-3 dietary fatty acid balance for the primary and secondary prevention of breast cancer in high-risk countries, such as the U.S.A...
  73. POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION
    Frank Sacks; Fiscal Year: 1991
    ..Biochemical validation of compliance with each treatment will be obtained. The discovery of an effective dietary supplement to treat mild hypertension would be of great interest and practical importance...