6 ketoprostaglandin f1 alpha

Summary

Summary: The physiologically active and stable hydrolysis product of EPOPROSTENOL. Found in nearly all mammalian tissue.

Top Publications

  1. ncbi Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis
    Iwao Arai
    Department of Pharmacology, Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama 331 9530, Japan
    Eur J Pharmacol 505:229-35. 2004
  2. ncbi TP receptors regulate renal hemodynamics during angiotensin II slow pressor response
    Noritaka Kawada
    Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Am J Physiol Renal Physiol 287:F753-9. 2004
  3. ncbi Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism
    Alexandre Ghuysen
    Hemodynamics Research Laboratory, University of Liege, Belgium
    J Pharmacol Exp Ther 310:964-72. 2004
  4. ncbi Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure
    A Caprani
    LBHP, CNRS UMR 7057, Universite Paris 7, Jussieu, Paris, France
    Bioelectromagnetics 25:313-5. 2004
  5. ncbi [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]
    Xiang Ying Kong
    Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    Yao Xue Xue Bao 40:916-9. 2005
  6. ncbi Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects
    Marta L Capone
    Department of Medicine and Center of Excellence on Aging, G D Annunzio University, School of Medicine, and G d Annunzio University Foundation, Chieti, Italy
    Circulation 109:1468-71. 2004
  7. ncbi Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids
    G C Agnoli
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, , Via Massarenti 9, Bologna, Italy
    Prostaglandins Leukot Essent Fatty Acids 64:95-103. 2001
  8. ncbi Endothelial cell COX-2 expression and activity in hypoxia
    Rebecca J Cook-Johnson
    Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
    Biochim Biophys Acta 1761:1443-9. 2006
  9. ncbi [Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia]
    Jian Sheng Li
    Geriatrics Department of Henan College of Traditional Chinese Medicine, Zhengzhou 450003, Henan, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:618-21. 2003
  10. ncbi Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells
    J W Lim
    Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul
    Lab Invest 81:349-60. 2001

Research Grants

Detail Information

Publications186 found, 100 shown here

  1. ncbi Prostanoid DP1 receptor agonist inhibits the pruritic activity in NC/Nga mice with atopic dermatitis
    Iwao Arai
    Department of Pharmacology, Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama 331 9530, Japan
    Eur J Pharmacol 505:229-35. 2004
    ....
  2. ncbi TP receptors regulate renal hemodynamics during angiotensin II slow pressor response
    Noritaka Kawada
    Cardiovascular Kidney Institute and Division of Nephrology and Hypertension, Georgetown University, Washington, DC 20007, USA
    Am J Physiol Renal Physiol 287:F753-9. 2004
    ..TP-Rs mediate all of the increase in RVR and FF, part of the increase in MAP, but are not implicated in the suppression of ANG I or increase in aldosterone. TP -/- mice have a basal increase in RVR and FF associated with ROS...
  3. ncbi Effect of BM-573 [N-terbutyl-N'-[2-(4'-methylphenylamino)-5-nitro-benzenesulfonyl]urea], a dual thromboxane synthase inhibitor and thromboxane receptor antagonist, in a porcine model of acute pulmonary embolism
    Alexandre Ghuysen
    Hemodynamics Research Laboratory, University of Liege, Belgium
    J Pharmacol Exp Ther 310:964-72. 2004
    ..We conclude that in this animal model of acute pulmonary embolism, infusion of BM-573 reduced pulmonary vasoconstriction. As a result, right ventricular-vascular coupling values were maintained at a maximal efficiency level...
  4. ncbi Experimental evidence of a potentially increased thrombo-embolic disease risk by domestic electromagnetic field exposure
    A Caprani
    LBHP, CNRS UMR 7057, Universite Paris 7, Jussieu, Paris, France
    Bioelectromagnetics 25:313-5. 2004
    ..We experimentally established, by comparing these two secretions with or without a Faraday cage, that the environmental electromagnetic field significantly increases the thrombo-embolic risks in this endothelial cell line...
  5. ncbi [Effect of phenolic alkaloids of Menispermum dauricum on thrombosis and platelet aggregation]
    Xiang Ying Kong
    Department of Pharmacology, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, China
    Yao Xue Xue Bao 40:916-9. 2005
    ..To observe the effect of phenolic alkaloids of Menispermum dauricum (PAMD) on thrombosis and platelet aggregation, and to explore its mechanism of action...
  6. ncbi Clinical pharmacology of platelet, monocyte, and vascular cyclooxygenase inhibition by naproxen and low-dose aspirin in healthy subjects
    Marta L Capone
    Department of Medicine and Center of Excellence on Aging, G D Annunzio University, School of Medicine, and G d Annunzio University Foundation, Chieti, Italy
    Circulation 109:1468-71. 2004
    ..The current controversy on the potential cardioprotective effect of naproxen prompted us to evaluate the extent and duration of platelet, monocyte, and vascular cyclooxygenase (COX) inhibition by naproxen compared with low-dose aspirin...
  7. ncbi Volume-induced natriuresis in healthy women: renal metabolism of prostacyclin and thromboxane, and physiological role of prostanoids
    G C Agnoli
    Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, , Via Massarenti 9, Bologna, Italy
    Prostaglandins Leukot Essent Fatty Acids 64:95-103. 2001
    ....
  8. ncbi Endothelial cell COX-2 expression and activity in hypoxia
    Rebecca J Cook-Johnson
    Rheumatology Unit, Royal Adelaide Hospital, North Terrace, Adelaide, SA 5000, Australia
    Biochim Biophys Acta 1761:1443-9. 2006
    ..The endothelial cell response to hypoxia involves increased production of the anti-thrombotic eicosanoid, PGI(2), which is dependent on COX-2 upregulation by a HIF-mediated process...
  9. ncbi [Change in intestinal free radical and prostaglandin metabolism in the aged rats with pneumococcus pneumonia]
    Jian Sheng Li
    Geriatrics Department of Henan College of Traditional Chinese Medicine, Zhengzhou 450003, Henan, China
    Zhongguo Wei Zhong Bing Ji Jiu Yi Xue 15:618-21. 2003
    ..To study the pathogenic mechanism underlying intestinal injury in the aged rat with pneumonia...
  10. ncbi Nuclear factor-kappaB regulates cyclooxygenase-2 expression and cell proliferation in human gastric cancer cells
    J W Lim
    Department of Pharmacology and Institute of Gastroenterology, Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul
    Lab Invest 81:349-60. 2001
    ..In conclusion, NF-kappaB mediates COX-2 expression, which may be related to cell proliferation, in human gastric cancer cells...
  11. ncbi Acute effects of the anti-inflammatory cyclooxygenase-2 selective inhibitor, flosulide, on renal plasma flow and glomerular filtration rate in rats
    A Turull
    , , Barcelona, Spain
    Inflammation 25:119-28. 2001
    ..Flosulide at 5 mg/kg reduced 6-keto-PGF1alpha whereas at 25 mg/kg and after indomethacin at 10 mg/kg a fall in 6-keto-PGF1alpha and TXB2 appeared. Our data suggest that acute COX-2 selective inhibition may alter renal function...
  12. ncbi Effects of specific COX-2-inhibition on renin release and renal and systemic prostanoid synthesis in healthy volunteers
    Dirk O Stichtenoth
    Institute of Clinical Pharmacology, Medizinische Hochschule Hannover, Germany
    Kidney Int 68:2197-207. 2005
    ..The renin-angiotensin system plays a critical role in cardiovascular function, but little is known about the effects of specific cyclooxygenase 2 (COX-2) inhibition on this system in healthy humans under physiologic conditions...
  13. ncbi Neutrophil elastase contributes to the development of ischemia-reperfusion-induced liver injury by decreasing endothelial production of prostacyclin in rats
    Kenji Okajima
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1, Kumamoto 860, Japan
    Am J Physiol Gastrointest Liver Physiol 287:G1116-23. 2004
    ....
  14. ncbi Cyclic mechanical stretching and interleukin-1alpha synergistically up-regulate prostacyclin secretion in cultured human uterine myometrial cells
    D Korita
    Department of Gynecology and Obstetrics, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Gynecol Endocrinol 18:130-7. 2004
    ..These results suggest that cyclic mechanical stretching by labor, in concert with IL-1alpha stimulation, contributes to the increase in myometrial PGI2 secretion during delivery...
  15. ncbi [Dynamic changes of plasma levels of prostacycline and thromboxane A2 and their correlation with the severity of hepatic injury in rats with nonalcoholic fatty liver disease]
    Jian Gao Fan
    Department of Gastroenterology, First People s Hospital, Shanghai Jiaotong University, Shanghai 200080, China
    Zhonghua Gan Zang Bing Za Zhi 12:681-3. 2004
    ..To investigate the dynamic changes of plasma levels of prostacycline (PGI2) and thromboxane A2 (TXA2) and their relationship with the severity of hepatic injury in rats with nonalcoholic fatty liver disease (NAFLD)...
  16. pmc Characterization of the induction of nitric oxide synthase and cyclo-oxygenase in rat aorta in organ culture
    D Bishop Bailey
    Department of Applied Pharmacology, National Heart and Lung Institute, Imperial College of Science and Technology, London
    Br J Pharmacol 121:125-33. 1997
    ..Also, unlike isolated cells in culture, the COX and NOS pathways were active independently; L-NAME had little effect on the activity of COX and indomethacin had little effect on the activity of NOS...
  17. ncbi Prostacyclin, thromboxane A and the effect of low-dose ASA in pregnancies at high risk for hypertensive disorders
    Merja Vainio
    Department of Obstetrics and Gynecology, Hyvinkaa Hospital, Hyvinkaa, Finland
    Acta Obstet Gynecol Scand 83:1119-23. 2004
    ..The aim of this study was to investigate the prostanoid production in pregnancies at high risk for hypertensive disorders, and the effect of low-dose acetylsalicylic acid (ASA) on prostanoids...
  18. ncbi Celecoxib inhibits ureteral contractility and prostanoid release
    Travis J Jerde
    Department of Surgery, Division of Urology, University of Wisconsin Medical School, Madison, Wisconsin 53792, USA
    Urology 65:185-90. 2005
    ..We have previously reported that the selective cyclooxygenase (COX)-2 inhibitor NS-398 inhibits ureteral contractility...
  19. ncbi [Insulin resistance and effects of intravenous acute saline load on renal production of prostaglandin I2 and thromboxane A2 in salt-sensitive hypertensive patients]
    Tao Ye
    Department of Cardiology, First Hospital of Xi an Jiaotong University, Xi an 710061, China
    Di Yi Jun Yi Da Xue Xue Bao 25:102-5. 2005
    ..To investigate insulin resistance and the effects of intravenous acute saline load on renal production of prostaglandin I(2) (PGI(2)) and thromboxane A(2) (TXA(2)) in salt-sensitive hypertensive patients...
  20. ncbi Thromboxane and prostacyclin biosynthesis in patients with acute spontaneous intracerebral hemorrhage
    Pertti Saloheimo
    Department of Neurology, Oulu University Central Hospital, Oulu Finland
    Thromb Res 115:367-73. 2005
    ..This marker of platelet activation has not been investigated in patients with acute spontaneous intracerebral hemorrhage (ICH)...
  21. ncbi [Characteristic changes of vascular tension factors in diabetic arterial occlusion of lower extremities]
    Bai nan Chen
    Department of Peripheral Vascular Diseases, Affiliated Hospital of Shandong TCM University, Jinan 250011
    Zhongguo Zhong Xi Yi Jie He Za Zhi 24:798-800. 2004
    ....
  22. ncbi Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro
    M M Sailaja Devi
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
    Prostaglandins Leukot Essent Fatty Acids 71:309-18. 2004
    ..Furthermore, PGE(1) prevented DNA damage and apoptosis induced by alloxan. These results indicate that PGE(1) prevents alloxan-induced cytotoxicity to RIN cells in vitro...
  23. ncbi Increased phospholipase A2 and thromboxane but not prostacyclin production by placental trophoblast cells from normal and preeclamptic pregnancies cultured under hypoxia condition
    Robin S Bowen
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, PO Box 33932, Shreveport, LA 71130, USA
    Placenta 26:402-9. 2005
    ..Relative hypoxia could contribute to the increase in TX production and result in vasoconstriction in placental vasculature in preeclampsia...
  24. ncbi Cyclooxygenase inhibition with acetylsalicylic acid unmasks a role for prostacyclin in erythropoietin-induced hypertension in uremic rats
    Marie Eve Rodrigue
    Research Centre and Division of Nephrology, CHUQ, L Hôtel Dieu de Québec Hospital and Department of Medicine, Laval University, Quebec, Canada
    Can J Physiol Pharmacol 83:467-75. 2005
    ..These results stress the importance of preserving PGI2 production when treating rhEPO-induced hypertension under uremic conditions...
  25. ncbi Human pharmacology of naproxen sodium
    Marta L Capone
    Department of Medicine and Center of Excellence on Aging, School of Medicine, G D Annunzio University, Chieti, Italy
    J Pharmacol Exp Ther 322:453-60. 2007
    ..In conclusion, neither of the two naproxen doses mimed the persistent and complete inhibition of platelet COX-1 activity obtained by aspirin, but marked heterogeneity was mitigated by the higher dose of the drug...
  26. ncbi Naproxen sodium in short-term prophylaxis of pure menstrual migraine: pathophysiological and clinical considerations
    G Allais
    Women s Headache Center, Department of Gynecology and Obstetrics, University of Turin, Via Ventimiglia 3, I 10126 Turin, Italy
    Neurol Sci 28:S225-8. 2007
    ..02), to 13.35+/-4.26 h in the 6th month (p<0.001). The intensity reduced from 2.4+/-0.11 pretreatment, to 1.2+/-0.10 in the 3rd month of treatment (p<0.0001), and 1.1+/-0.07 in the 6th month (p<0.0001)...
  27. ncbi Early postnatal ibuprofen and indomethacin effects in suckling and weanling rat kidneys
    Jamal Hasan
    Department of Pediatrics, Division of Neonatal Perinatal Medicine, University of California Irvine, Irvine, CA, United States
    Prostaglandins Other Lipid Mediat 85:81-8. 2008
    ..These long-term, sustained effects may explain in part, why indomethacin exerts more severe adverse renal effects than ibuprofen, when administered during early postnatal life...
  28. ncbi Role of COX-2-derived metabolites in regulation of the renal hemodynamic response to norepinephrine
    M T Llinas
    Department of Physiology, School of Medicine, University of Murcia, 30100 Murcia, Spain
    Am J Physiol Renal Physiol 281:F975-82. 2001
    ..Our results show that COX-2 inhibition potentiates the renal hemodynamic effects of NE and propose that the PG involved in modulating them are mainly derived from COX-2 activity...
  29. ncbi Chronic thromboxane synthase inhibition prevents fructose-induced hypertension
    D Galipeau
    Division of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada
    Hypertension 38:872-6. 2001
    ..Based on these data, we conclude that the potent vasoconstrictor thromboxane is involved in the link between hyperinsulinemia/insulin resistance and hypertension...
  30. ncbi Signs of platelet activation, but not lipid peroxidation, in fetal blood associated with functional and structural umbilicoplacental lesions in pregnancies complicated by impaired glucose metabolism
    P Saldeen
    Department of Obstetrics and Gynecology, Malmo University Hospital, Lund University, Malmo, Sweden
    J Matern Fetal Neonatal Med 12:165-71. 2002
    ..To study the influence of platelet activation and lipid peroxidation in fetal blood on umbilical vascular prostanoid synthesis and placental morphology in diabetic pregnancy...
  31. ncbi Nitric oxide, prostanoids, cyclooxygenase, and angiogenesis in colon and breast cancer
    R J Bing
    Department of Experimental Cardiology, Huntington Medical Research Institutes, Pasadena, CA 91101, USA
    Clin Cancer Res 7:3385-92. 2001
    ..Additionally, we investigated differences in expression and histological localization of COX-2 in colon and breast cancer...
  32. ncbi [Relationship between cyclooxygenase-2 protein expression, prostaglandins levels and biologic behavior in ovarian carcinoma tissue]
    Lixia Tang
    Department of Obstetrics and Gynecology, Sixth Hospital of Dalian, Dalian 116001, China
    Zhonghua Fu Chan Ke Za Zhi 37:687-90. 2002
    ..To study the relationship between cyclooxygenase-2 (COX-2) protein expression, prostaglandins levels assay and ovarian carcinoma biologic behavior in ovarian carcinoma tissue...
  33. ncbi Cyclooxygenase inhibitor blocks rebound response after NO inhalation in an endotoxin model
    Luni Chen
    Department of Medical Sciences, Clinical Physiology, University Hospital, SE 751 85 Uppsala, Sweden
    Am J Physiol Heart Circ Physiol 284:H290-8. 2003
    ..We conclude that the rebound response to INO discontinuation is related to COX products...
  34. ncbi 1A-779 attenuates angiotensin-(1-7) depressor response in salt-induced hypertensive rats
    Mohamed A Bayorh
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, GA 30310 1495, USA
    Peptides 23:57-64. 2002
    ....
  35. ncbi [Effects of fast decompression on prostaglandins content in cerebral tissue of guinea pigs]
    Tie Lou Chen
    Naval Medical Research Institute, Shanghai, China
    Space Med Med Eng (Beijing) 15:212-3. 2002
    ..It showed very significant differences as compared with control group (P<0.01). Conclusion. The content of PGs in cerebral tissue increased markedly after fast decompression, and may cause cerebral injury...
  36. ncbi Ischemia/reperfusion-induced increase in the hepatic level of prostacyclin is mainly mediated by activation of capsaicin-sensitive sensory neurons in rats
    Naoaki Harada
    Department of Laboratory Medicine, Kumamoto University School of Medicine, Honjo 1 1 1, Kumamoto 068 0811, Japan
    J Lab Clin Med 139:218-26. 2002
    ..In the sensory neuron-mediated enhancement of endothelial production of prostacyclin, CGRP-induced activation of both endothelial NOS and cyclooxygenase-1 may be critically involved...
  37. ncbi Effects of nicotine on thromboxane/prostacyclin balance in myocardial ischemia
    R Nemr
    Laboratory of Physiology, Faculty of Medical Sciences, Lebanese University, Beirut, Lebanon
    Prostaglandins Leukot Essent Fatty Acids 68:191-5. 2003
    ..Therefore, these results provide one explanation on how nicotine might worsen myocardial ischemia...
  38. ncbi Influences of prostanoids and nitric oxide on post-suspension hypotension in female Sprague-Dawley rats
    D Eatman
    Departments of Pharmacology Toxicology, Morehouse School of Medicine, 720 Westview Drive, S W, Atlanta, GA 30310 1495, USA
    Prostaglandins Leukot Essent Fatty Acids 68:197-205. 2003
    ..Therefore, the post-suspension reduction in mean arterial pressure is due mostly to overproduction of nitric oxide and to a lesser extent prostacyclin...
  39. pmc Inhibition of cyclooxygenase-2 aggravates doxorubicin-mediated cardiac injury in vivo
    N P Dowd
    Department of Anaesthesia and Intensive Care, Beaumont Hospital, Dublin, Ireland
    J Clin Invest 108:585-90. 2001
    ..These data raise the possibility of protecting the heart during the administration of doxorubicin by prior administration of prostacyclin...
  40. ncbi Role of prostaglandins on mechanical scratching-induced cutaneous barrier disruption in mice
    N Futaki
    Pharmacology Laboratory, Medicinal Research Laboratories, Taisho Pharmaceutical Co, Ltd, Kita ku, Saitama shi, Saitama, Japan
    Exp Dermatol 16:507-12. 2007
    ..These results suggest that the elevation of cutaneous PG production induced by mechanical scratching is involved in the repair of the skin damage caused by the scratching...
  41. ncbi Clinical implication of the changes of cAMP, TXA2 and PGI2 in CSF of asphyxiated newborns
    Hanchu Liu
    Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030
    J Huazhong Univ Sci Technolog Med Sci 23:195-7, 200. 2003
    ..05). The results suggested that the concentration of cAMP, TXA2 and T/K ratio in CSF after neonatal asphyxia might be sensitive markers in evaluating the severity of brain damage in early stage and predicting the future outcome...
  42. ncbi Effects of cyclooxygenases inhibitors on vasoactive prostanoids and thrombin generation at the site of microvascular injury in healthy men
    Ewa Tuleja
    Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland
    Arterioscler Thromb Vasc Biol 23:1111-5. 2003
    ..We tested the hypothesis that naproxen, contrary to rofecoxib, exerts antithrombotic effects...
  43. ncbi Effect of cyclooxygenase-2 inhibitor (celecoxib) on the infarcted heart in situ
    T Yamamoto
    Huntington Medical Research Institutes, Department of Experimental Cardiology, Pasadena, Calif 91101, USA
    Pharmacology 63:28-33. 2001
    ..Aspirin was most effective in reducing myocardial PGI2 synthesis and formation of TXA2. Myocardial effects of celecoxib resemble those of NCX-4016, although the two compounds have different modes of action...
  44. ncbi The response of muscle interstitial prostaglandin E(2)(PGE(2)), prostacyclin I(2)(PGI(2)) and thromboxane A(2)(TXA(2)) levels during incremental dynamic exercise in humans determined by in vivo microdialysis
    M Karamouzis
    Ergophysiology Laboratory, Aristotle University of Thessaloniki, Greece
    Prostaglandins Leukot Essent Fatty Acids 64:259-63. 2001
    ..This is further evidence that exercise induces propitious biochemical changes. Furthermore, the muscle production of arachidonic acid metabolites during exercise depends on the intensity of the exercise...
  45. ncbi Modifications produced by selective inhibitors of cyclooxygenase and ultra low dose aspirin on platelet activity in portal hypertension
    Francisco X Eizayaga
    Universidad Maimónides, Buenos Aires, Argentina
    World J Gastroenterol 13:5065-70. 2007
    ....
  46. ncbi Lack of endothelium-derived hyperpolarizing factor (EDHF) up-regulation in endothelial dysfunction in aorta in diabetic rats
    Gabor Csanyi
    Department of Pathophysiology, Albert Szent Gyorgyi Medical and Pharmaceutical Center, University of Szeged, Semmelweis 1, 6725 Szeged, Hungary
    Pharmacol Rep 59:447-55. 2007
    ..The above alterations in the endothelial function may play an important role in the development of endothelial dysfunction and vascular complications of diabetes...
  47. ncbi The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis
    George N Tzanakakis
    Department of Histology, School of Medicine, University of Crete, Heraklion, Greece
    Int J Gastrointest Cancer 32:23-30. 2002
    ....
  48. ncbi Antenatal administration of celecoxib, a selective cyclooxygenase (COX)-2 inhibitor, appears to improve placental perfusion in the pregnant rabbit
    Nicole Hausman
    Division of Maternal Fetal Medicine, Women s Hospital, Long Beach Memorial Medical Center, 2801 Atlantic Avenue, Long Beach, CA, USA
    Prostaglandins Other Lipid Mediat 70:303-15. 2003
    ..05). Maternal administration of celecoxib appears to preferentially increase placental vasodilators and decrease placental TxA2, suggesting that the drug may increase uteroplacental perfusion without adverse fetal outcome...
  49. ncbi Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit
    Alan H Stephenson
    Department of Pharmacological and Physiological Science, Saint Louis University School of Medicine, Missouri 63104, USA
    Am J Physiol Heart Circ Physiol 284:H2153-61. 2003
    ....
  50. ncbi [Increase of the prostacyclin/thromboxane A2 ratio in the plasma of rabbits treated with cicletanine, a new antihypertensive agent]
    C Deby
    Laboratoire de Radiobiologie et de Biochimie, , Belgique
    Arch Mal Coeur Vaiss 81:97-9. 1988
    ..After cicletanine, a new hypertensive drug, rabbits of the second type responded like those of the first type, without severe physiopathological responses to AA injections...
  51. ncbi Forskolin stimulates prostaglandin synthesis in rabbit heart by a mechanism that requires calcium and is independent of cyclic AMP
    J L Williams
    Department of Pharmacology, College of Medicine, University of Tennessee, Memphis 38163
    Circ Res 67:1247-56. 1990
    ..These results indicate that forskolin-stimulated PG synthesis in rabbit heart is independent of cAMP and requires calcium from both extracellular and intracellular sources...
  52. ncbi Vascular resistance and Kf in normal and PMA-injured rabbit lungs: effects of adenosine
    J D Bradley
    Department of Pharmacology, St Louis University School of Medicine, Missouri 63104
    J Appl Physiol (1985) 71:417-24. 1991
    ..These results suggest that protection by ADO is not mediated by the altering of cyclooxygenase products or by leukocyte adherence...
  53. ncbi Endotoxin-induced lung injury in rats: role of eicosanoids
    S W Chang
    Pulmonary Division, University of Colorado Health Sciences Center, Denver 80262
    J Appl Physiol 66:2407-18. 1989
    ..We conclude that although lung eicosanoids are activated during endotoxemia, they do not play a crucial role in the development of acute lung vascular injury in rats...
  54. ncbi Arachidonic acid metabolism and pathophysiologic aspects of subarachnoid hemorrhage in rats
    P Gaetani
    Department of Surgery, University of Pavia, IRCCS Policlinico S Matteo, Italy
    Stroke 21:328-32. 1990
    ....
  55. ncbi Cardiovascular and renin responses to desmopressin in humans: role of prostacyclin and beta-adrenergic systems
    K Hasunuma
    Second Department of Internal Medicine, School of Medicine, Chiba University, Japan
    Am J Physiol 260:H1031-6. 1991
    ....
  56. ncbi Paraquat-induced lung injury: prevention by N-tert-butyl-alpha-phenylnitrone, a free-radical spin-trapping agent
    T Sata
    Department of Medicine, University of Illinois, Chicago College of Medicine
    Am J Physiol 262:L147-52. 1992
    ..PBN (2.3 mM) markedly attenuated all evidence of lung injury, which was also reduced by catalase, mannitol, ethanol, and vitamin E.(ABSTRACT TRUNCATED AT 250 WORDS)..
  57. ncbi Increased in vivo production of thromboxane in patients with sickle cell disease is accompanied by an impairment of platelet functions to the thromboxane A2 agonist U46619
    I Foulon
    , , France
    Arterioscler Thromb 13:421-6. 1993
    ..Our results may also provide a rationale for using antiplatelet drugs in the prophylaxis of thrombotic complications in sickle cell patients...
  58. ncbi Essential fatty acid-deficient rats are resistant to oleic acid-induced pulmonary injury
    H A Ball
    Department of Cell and Molecular Pharmacology and Experimental Therapeutics, Medical University of South Carolina, Charleston
    J Appl Physiol 67:811-6. 1989
    ..05) rise in the bronchoalveolar lavage levels of iLTB4 and i6-keto-PGF1 alpha. These results suggest that arachidonic acid metabolites contribute to oleic acid-induced pulmonary permeability...
  59. ncbi Products of cyclooxygenase mediate the responses of the guinea pig trachea to hydrogen peroxide
    Y Gao
    Center for Experimental Therapeutics, Baylor College of Medicine, Houston, Texas 77030
    J Appl Physiol 74:2105-11. 1993
    ..These findings demonstrate that the responses of the guinea pig trachea to H2O2 are mediated mainly by products of cyclooxygenase and that the effects of H2O2 are modulated by the epithelium...
  60. ncbi Effects of sucralfate on gastric prostaglandin and leukotriene synthesis: relationship to protective actions
    J L Wallace
    Department of Physiology, Queen s University, Kingston, Ont, Canada
    Can J Physiol Pharmacol 66:666-70. 1988
    ..The present study supports the hypothesis that prostaglandins do not mediate the protection afforded by exposure to sucralfate...
  61. ncbi Vasoconstriction and increased flow: two principal mechanisms of shear stress-dependent endothelial autacoid release
    M Hecker
    Institute of Applied Physiology, University of Freiburg, Germany
    Am J Physiol 265:H828-33. 1993
    ..Charybdotoxin, an inhibitor of Ca(2+)-activated K+ channels, and glibenclamide, an inhibitor of the ATP-sensitive K+ channel, had no effect on the shear stress-dependent release of NO.(ABSTRACT TRUNCATED AT 250 WORDS)..
  62. ncbi Role of prostanoids in cerebrovascular responses during seizures in piglets
    D W Busija
    Department of Physiology and Biophysics, University of Tennessee, Memphis 38163
    Am J Physiol 256:H120-5. 1989
    ....
  63. ncbi Role of peptidoleukotrieens in hypoxic pulmonary vasoconstriction in rats
    T J McDonnell
    Cardiovascular Pulmonary Research Laboratory, University of Colorado Health Sciences Center, Denver 80262
    Am J Physiol 259:H751-8. 1990
    ..These results do not support the hypothesis that leukotrienes mediate HPV in the rat...
  64. ncbi Incorporation of arachidonic acid into lipids of the isolated perfused rat lung
    F H Chilton
    Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21239
    J Appl Physiol 66:2763-71. 1989
    ..LTC4 had a profoundly different radiospecific activity compared with LTB4 and 6-keto-PGF1 alpha, suggesting a different source of AA as contributing to the production of this eicosanoid.(ABSTRACT TRUNCATED AT 250 WORDS)..
  65. ncbi Relationship between thromboxane/prostacyclin ratio and diabetic vascular complications
    T Hishinuma
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
    Prostaglandins Leukot Essent Fatty Acids 65:191-6. 2001
    ..The monitoring and improvement of TXA2/PGI2 ratio could be useful for the prevention of diabetic vascular complications...
  66. ncbi Enhanced platelet sensitivity to prostacyclin in patients in an active stage of Takayasu arteritis
    T Watanabe
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8519, Japan
    Thromb Res 104:77-83. 2001
    ..The increase in sensitivity of the platelets to prostacyclin could be a compensatory mechanism against a decrease in the prostanoid production, presumably associated with endothelial dysfunction...
  67. ncbi Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits
    Nabil Foudi
    Bichat Hospital, 1INSERM U698, Paris Cedex 18, France
    Am J Physiol Heart Circ Physiol 297:H1882-8. 2009
    ..These observations suggest that the local induction of COX-2 during atherosclerosis decreased the sensitivity to norepinephrine and that COX-2 inhibitors may increase vascular reactivity at sites of atherosclerotic lesions...
  68. ncbi [Relationship between syndrome differentiation of traditional Chinese medicine and vascular endothelial function in patients with diabetic arterial occlusion of lower extremities]
    Lian qing SUN
    Department of Peripheral Vascular Diseases, Affiliated Hospital, Shandong University of Traditional Chinese Medicine, Jinan, Shandong Province 250011, China
    Zhong Xi Yi Jie He Xue Bao 5:621-4. 2007
    ..To investigate the relationship between syndrome differentiation of traditional Chinese medicine (TCM) and characteristic changes of vascular endothelial function in patients with diabetic arterial occlusion (DAO) of lower extremities...
  69. ncbi Normalization of vasoactive changes in preeclampsia precedes clinical recovery
    Nonna Makkonen
    Department of Obstetrics and Gynecology, Kuopio University Hospital, 70211 Kuopio, Finland
    Hypertens Pregnancy 21:51-64. 2002
    ..The objective of this study is to compare the serum levels of fibronectin, nitric oxide (NO), cyclic guanosine-monophosphate, endothelin-1, and 6-keto-prostaglandin-F 1alpha in women with and without preeclampsia before and after delivery...
  70. ncbi Differential effects of immunosuppressive drugs on COX-2 activity in vitro and in kidney transplant patients in vivo
    Bente Jespersen
    Department of Nephrology, Odense University Hospital, Odense, Denmark
    Nephrol Dial Transplant 24:1644-55. 2009
    ..It was hypothesized that calcineurin inhibitors suppress vascular cyclooxygenase (COX)-2 and exert a reciprocal influence on in vivo prostacyclin and thromboxane. This could contribute to cardiovascular morbidity in transplanted patients...
  71. ncbi Differential regulation of prostacyclin and thromboxane by dexamethasone and celecoxib during oxidative stress in newborn rabbits
    Naomi Ozaki
    Department of Pediatrics, University of California, Irvine Medical Center, Orange, USA
    Prostaglandins Other Lipid Mediat 70:61-78. 2002
    ..Further studies are required to examine whether Cel can be used as a therapeutic alternative to Dex for oxygen-induced injury in the newborn...
  72. ncbi Intravenous glutamine enhances COX-2 activity giving cardioprotection
    Jonathan McGuinness
    The Royal College of Surgeons in Ireland, Department of Surgery, Beaumont Hospital, Dublin, Ireland
    J Surg Res 152:140-7. 2009
    ..We investigated whether acute intravenous glutamine, through an effect on cyclooxygenase (COX)-2 and heat shock protein (HSP) 72, might induce preconditioning...
  73. ncbi Role of human heme oxygenase-1 in attenuating TNF-alpha-mediated inflammation injury in endothelial cells
    Taketoshi Kushida
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    J Cell Biochem 87:377-85. 2002
    ..These results demonstrate that overexpressing HO-1 mitigated the TNF-alpha-mediated changes in cell cycle progression and apoptosis, perhaps by a decrease in the levels of COX activity...
  74. ncbi Platelet aggregation, eicosanoid production and thrombogenic ratio in individuals at high cardiovascular risk consuming meat enriched in walnut paste. A crossover, placebo-controlled study
    Amaia Canales
    Departamento de Nutrición y Bromatología I Nutrición, Universidad Complutense de Madrid, Madrid E 28040, Spain
    Br J Nutr 102:134-41. 2009
    ..066) in volunteers whose serum cholesterol levels were > or = 2200 mg/l. The WM diet should be considered a functional meat because it improves the thrombogenic status mainly in individuals with high-cholesterol levels or high BMI...
  75. pmc An active triple-catalytic hybrid enzyme engineered by linking cyclo-oxygenase isoform-1 to prostacyclin synthase that can constantly biosynthesize prostacyclin, the vascular protector
    Ke He Ruan
    Department of Pharmacological and Pharmaceutical Sciences, Center for Experimental Therapeutics and Pharmacoinformatics, University of Houston, TX, USA
    FEBS J 275:5820-9. 2008
    ....
  76. pmc Predominant basal directional release of thromboxane, but not prostacyclin, by placental trophoblasts from normal and preeclamptic pregnancies
    S Zhao
    Department of Obstetrics and Gynecology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    Placenta 29:81-8. 2008
    ..To investigate apical and basal releases of thromboxane (TX) and prostacyclin (PGI2) by trophoblasts (TCs) from normal and preeclamptic (PE) placentas...
  77. ncbi Contribution of interaction between nitric oxide and cyclooxygenases to the production of prostaglandins in carrageenan-induced inflammation
    Masaki Toriyabe
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Anesthesiology 101:983-90. 2004
    ..This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation...
  78. pmc Protective effect of Weikang decoction and partial ingredients on model rat with gastric mucosa ulcer
    Tuo Ying Fan
    Shenzhen Donghu Hospital, Shenzhen 518020, Guangdong Province, China
    World J Gastroenterol 11:1204-9. 2005
    ..To investigate the protective mechanisms of Weikang (WK) decoction on gastric mucosae...
  79. ncbi Chronic administration of ethyl docosahexaenoate reduces gerbil brain eicosanoid productions following ischemia and reperfusion
    Dehua Cao
    Department of Biology, School of Life Sciences, Nanjing University, PR China
    J Nutr Biochem 17:234-41. 2006
    ..These data suggest that the E-DHA (200 mg/kg) pretreatment reduces the postischemic eicosanoid productions, which may be due to its reduction of the brain lipid AA content...
  80. ncbi Role of peroxynitrite in the process of vascular tone regulation by nitric oxide and prostanoids--a nanotechnological approach
    Allyson J Kozak
    Department of Chemistry and Biochemistry, Ohio University, 350 West State Street, Athens, OH 45701, USA
    Prostaglandins Leukot Essent Fatty Acids 72:105-13. 2005
    ....
  81. ncbi Melatonin reduces pancreatic prostaglandins production and protects against caerulein-induced pancreatitis in rats
    Han Ming Chen
    Department of Surgery, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taipei, Taiwan
    J Pineal Res 40:34-9. 2006
    ..Moreover, melatonin treatment changed local PG production toward control level. Higher dose of melatonin was somewhat more effective in preventing the caerulein-induced alterations than was the lower dose...
  82. ncbi Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kinin-dependent mechanism
    Vito De Gennaro Colonna
    Department of Pharmacology, Chemotherapy and Medical Toxicology, University of Milan, Milan, Italy
    J Hypertens 24:95-102. 2006
    ....
  83. ncbi [Protective effect of 3,4-oxo-isopropylidene-shikimic acid on vascular endothelial cell injured by hydrogen peroxide]
    Yi Ma
    Department of Pharmacology, Beijing University of Traditional Chinese Medicine, Beijing 100102, China
    Yao Xue Xue Bao 38:897-9. 2003
    ..To study the effect of 3,4-oxo-isopropylidene-shikimic acid (ISA) on H2O2 (200 mol.L-1, 4 h) injured human umbilical vein endothelial cells (HUVEC)...
  84. pmc Substance P-induced cyclooxygenase-2 expression in human umbilical vein endothelial cells
    Margherita Gallicchio
    Department of Anatomy, Pharmacology and Forensic Medicine, University of Turin, Via Pietro Giuria, 9, 10125 Torino, Italy
    Br J Pharmacol 147:681-9. 2006
    ..The study shows HUVEC to possess functional NK(1) and NK(2) receptors, which mediate the ability of SP to induce expression of COX-2 in HUVEC, thus showing a previously-undetected effect of SP on endothelial cells...
  85. pmc Antithrombin reduces reperfusion-induced hepatic metastasis of colon cancer cells
    Masanao Kurata
    Department of Surgery, Functional and Regulatory Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba Tennoudai 1 1 1, Tsukuba, Japan
    World J Gastroenterol 12:60-5. 2006
    ..To examine whether antithrombin (AT) could prevent hepatic ischemia/reperfusion (I/R)-induced hepatic metastasis by inhibiting tumor necrosis factor (TNF)-alpha-induced expression of E-selectin in rats...
  86. ncbi Catheter-based prostacyclin synthase gene transfer prevents in-stent restenosis in rabbit atheromatous arteries
    Yasushi Numaguchi
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cardiovasc Res 61:177-85. 2004
    ..The aim of this study is to evaluate how overexpression of endogenous prostacyclin exerts those beneficial effects in atheromatous arteries...
  87. ncbi Differential suppression of menstrual fluid prostaglandin F2a, prostaglandin E2, 6-keto prostaglandin F1a and thromboxane B2 by suprofen in women with primary dysmenorrhea
    M Yusoff Dawood
    Department of Obstetrics and Gynecology, West Virginia University School of Medicine, Robert C Byrd Health Science Center, Morgantown, WV 26506 9186, USA
    Prostaglandins Other Lipid Mediat 83:146-53. 2007
    ..In contrast, nine rated suprofen excellent to fair while two rated poor. Thus, suprofen was clinically effective but the differential suppression of prostanoids favors 200mg which spares 6-keto PGF1a...
  88. ncbi Effects of exercise on platelet and aortic functions in aged rats
    Y Tanaka
    Department of Neurosurgery, San in Rosai Hospital, Yonago, Tottori, Japan
    Acta Physiol Scand 179:155-65. 2003
    ....
  89. ncbi Atrial natriuretic peptide reduces ischemia/reperfusion-induced spinal cord injury in rats by enhancing sensory neuron activation
    Takuya Nakayama
    Departments of Cardiovascular Surgery, Nagoya City University Graduate School of Medical Sciences, Mizuho cho, Mizuho ku, Nagoya, Japan
    J Pharmacol Exp Ther 322:582-90. 2007
    ..These results strongly suggest that ANP might reduce I/R-induced SCI in rats by inhibiting neutrophil activation through enhancement of sensory neuron activation...
  90. ncbi Prostacyclin in endotoxemia-induced acute kidney injury: cyclooxygenase inhibition and renal prostacyclin synthase transgenic mice
    Wei Wang
    Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado, USA
    Am J Physiol Renal Physiol 293:F1131-6. 2007
    ..This effect may be overridden by excessive activation of the renin-angiotensin system in renal-specific PGIs Tg mice...
  91. ncbi Gastric mucosal levels of prostaglandins and leukotrienes in patients with gastric ulcer after treatment with rabeprazole in comparison to treatment with ranitidine
    Michiyo Okazaki
    Department of Gastroenterology, Kochi Red Cross Hospital, Kochi, Japan
    J Med Invest 54:83-90. 2007
    ..We therefore examined the effectiveness of a PPI in protecting the gastric mucosa...
  92. ncbi Endothelial COX-2 induction by hypoxia liberates 6-keto-PGF1 alpha, a potent epithelial secretagogue
    Sean P Colgan
    Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women s Hospital, Boston, MA
    Adv Exp Med Biol 507:107-12. 2002
  93. ncbi Inhibitory effects of ligustrazine, a modulator of thromboxane-prostacycline-nitric oxide balance, on renal injury in rats with passive Heyman nephritis
    Yingwei Wang
    Department of Immunology, Nanjing Medical University, Nanjing, PR China
    Nephron Physiol 98:p80-8. 2004
    ....
  94. ncbi Analysis of urinary prostacyclin and thromboxane/prostacyclin ratio in patients with rheumatoid arthritis using gas chromatography/selected ion monitoring
    T Hishinuma
    Department of Pharmaceutical Sciences, Tohoku University Hospital, Sendai, Japan
    Prostaglandins Leukot Essent Fatty Acids 65:85-90. 2001
    ..The present findings demonstrated that endogenous prostacyclin and thromboxane production increased in patients without medication, and prostacyclin production decreased with medication...
  95. ncbi Transcardiac 8-iso-prostaglandin F(2 alpha)generation from acute myocardial infarction heart: insight into abrupt reperfusion and oxidant stress
    Y Kijima
    Cardiovascular Division, Ishinkai Yao General Hospital, Yao, Osaka, Japan
    Prostaglandins Leukot Essent Fatty Acids 64:161-6. 2001
    ..841, P<0.01), but not with those of the other two eicosanoids. In conclusion, transcardiac 8-iso-PGF(2 alpha)generation is a reliable marker for the size of myocardium exposed to oxidant stress...
  96. ncbi The influence of the phase of the estrous cycle on sheep endometrial tissue response to lipopolysaccharide
    K E Vagnoni
    Department of Animal, Dairy, and Veterinary Sciences, Utah State University, Logan 84322, USA
    J Anim Sci 79:463-9. 2001
    ..20) occurred in endometrial tissue following lipopolysaccharide exposure. These data suggest that the phase of the estrous cycle regulates prostaglandin production by immune-challenged endometrial tissue...
  97. ncbi Effects of nicardipine on the ex vivo release of eicosanoids after experimental subarachnoid hemorrhage
    R Rodriguez Y Baena
    Department of Surgery, Neurosurgical Section, Policlinico S Matteo, Italy
    J Neurosurg 71:903-8. 1989
    ....
  98. ncbi [Experimental animal studies of the effect of selective proximal vagotomy on the prostaglandin content of the gastric mucosa in the Shay ulcer model]
    S Dubecz
    III Chirurgischen Klinik,
    Z Exp Chir Transplant Kunstliche Organe 22:45-9. 1989
    ..The SPV is significant as you know for the secretion of H+ion and bicarbonate, but also for the normalization of increased TXB2 on the basis of our investigation results...
  99. ncbi Prostaglandins, leukotrienes, and other arachidonic acid metabolites in the pathogenesis of otitis media
    T T Jung
    Department of Surgery, Loma Linda University School of Medicine, CA
    Laryngoscope 98:980-93. 1988
    ..It is clear from these studies that arachidonic acid metabolites are important inflammatory mediators in the pathogenesis of otitis media...
  100. ncbi Arachidonic acid metabolism during early development of ovine embryos: a possible relationship to shedding of the zona pellucida
    B L Sayre
    Department of Animal Science, Virginia Polytechnic Institute, State University, Blacksburg 24061 0306
    Prostaglandins 45:557-69. 1993
    ..05) than that for embryos in any group with INDO. The results indicate that early ovine embryos can convert AA to various compounds in vitro, and prostaglandins may have a role in the hatching of sheep embryos from the zona pellucida...
  101. ncbi Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia
    R F Grace
    Department of Anaesthesia and Pain Management, The University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia
    Pain 89:117-25. 2001
    ..We propose that both central and peripheral mechanisms are associated with the hyperalgesia and that the findings lend indirect support to a central action for non-steroidal anti-inflammatory drugs...

Research Grants13

  1. EICOSANOIDS AND PULMONARY VASCULAR TONE
    SANDRA PFISTER; Fiscal Year: 2002
    ....
  2. Prostaglandin I synthase, Thromboxane A synthase & Prostaglandin E synthase
    Ke He Ruan; Fiscal Year: 2009
    ....
  3. STRUCTURE & FUNCTION RELATIONSHIP: PROSTANOID RECEPTORS
    Ke He Ruan; Fiscal Year: 2008
    ..Determine the solution conformation of segments comprising the intracellular domains. ..
  4. Closure of the Primate Ductus Arteriosus
    Ronald Clyman; Fiscal Year: 2006
    ..These studies should increase our understanding of how the patent ductus arteriosus alters pulmonary function in the preterm infant and what produces its permanent closure. ..
  5. Effects of EECP on Arterial Function
    RANDY BRAITH; Fiscal Year: 2006
    ..Only through identification of specific mechanisms behind the efficacy of EECP, will this treatment oDtion receive acceptance by the clinical community in the treatment of svmptomatic CAD. ..
  6. Interaction of age and gender on NO bioavailability
    Jennifer Sullivan; Fiscal Year: 2005
    ..We will then determine the affects of age and gender on antioxidant systems and the sources of oxidative stress in the mesenteric vasculature. ..
  7. Ginkgo Biloba Extract & The Insulin Resistance Syndrome
    George Kudolo; Fiscal Year: 2004
    ..The results of this study should also provide valuable information for designing new therapeutic strategies for the treatment of diseases in the insulin resistance syndrome. ..
  8. LIVER REGENERATION IN PEDIATRIC LIVER DISEASE
    DAVID RUDNICK; Fiscal Year: 2004
    ..In this grant we propose to determine the effects of prostaglandins on ROS synthesis, expression of genes regulating ROS metabolism, and expression and activity of negative regulators of cytokine signaling during liver regeneration. ..
  9. LIVER REGENERATION IN PEDIATRIC LIVER DISEASE
    DAVID RUDNICK; Fiscal Year: 2004
    ..abstract_text> ..
  10. PATHOGENIC MECHANISMS AND INTERVENTION STRATEGIES IN HUS
    Richard Siegler; Fiscal Year: 2002
    ....
  11. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..
  12. CYTOCHROME P450 EICOSANOIDS AND PULMONARY HEMODYNAMICS
    Alan Stephenson; Fiscal Year: 2002
    ..abstract_text> ..
  13. Hepatobiliary Pathophysiology of Liver Regeneration
    DAVID RUDNICK; Fiscal Year: 2009
    ..abstract_text> ..