f2 isoprostanes

Summary

Summary: Isoprostanes derived from the free radical oxidation of ARACHIDONIC ACID. Although similar in structure to enzymatically synthesized prostaglandin F2alpha (DINOPROST), they occur through non-enzymatic oxidation of cell membrane lipids.

Top Publications

  1. ncbi Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes
    Richard S Bruno
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 18:509-18. 2007
  2. ncbi An improved method for the measurement of urinary and plasma F2-isoprostanes using gas chromatography-mass spectrometry
    T A Mori
    Department of Medicine and the Western Australian Heart Research Institute, University of Western Australia, Perth, Perth, 6000, Western
    Anal Biochem 268:117-25. 1999
  3. ncbi F2-isoprostanes as biomarkers of lipid peroxidation in patients with chronic renal failure
    Ingrid Wiswedel
    Department of Pathological Biochemistry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Biofactors 24:201-8. 2005
  4. ncbi Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes
    Michael J Sampson
    Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital National Health Service Trust, Norwich, UK
    Diabetes Care 25:537-41. 2002
  5. pmc The relationship between dose of vitamin E and suppression of oxidative stress in humans
    L Jackson Roberts
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 43:1388-93. 2007
  6. ncbi DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity
    Heno F Lopes
    Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA
    Hypertension 41:422-30. 2003
  7. ncbi Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes
    Alan W Taylor
    Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
    Anal Biochem 350:41-51. 2006
  8. ncbi 8-iso-prostaglandin F2alpha as a marker of tissue oxidative damage in bovine retained placenta
    Marta Kankofer
    Department of Biochemistry, Faculty of Veterinary Medicine, Agricultural University, Lublin, Poland
    Prostaglandins Other Lipid Mediat 70:51-9. 2002
  9. ncbi A mouse model of angiotensin II slow pressor response: role of oxidative stress
    Noritaka Kawada
    Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, 3800 Reservoir Road NE, Washington, DC 20007 2197, USA
    J Am Soc Nephrol 13:2860-8. 2002
  10. ncbi Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E
    Raffaele De Caterina
    Chair of Cardiology, G D Annunzio University, Chieti, Italy
    Circulation 106:2543-9. 2002

Detail Information

Publications230 found, 100 shown here

  1. ncbi Dietary zinc restriction in rats alters antioxidant status and increases plasma F2 isoprostanes
    Richard S Bruno
    Department of Nutritional Sciences, University of Connecticut, Storrs, CT 06269, USA
    J Nutr Biochem 18:509-18. 2007
    ..Collectively, zinc deficiency increased oxidative stress, which may be partially explained by increased CYP activity and reductions in hepatic alpha-tocopherol and gamma-tocopherol and in plasma uric acid...
  2. ncbi An improved method for the measurement of urinary and plasma F2-isoprostanes using gas chromatography-mass spectrometry
    T A Mori
    Department of Medicine and the Western Australian Heart Research Institute, University of Western Australia, Perth, Perth, 6000, Western
    Anal Biochem 268:117-25. 1999
    ..The inclusion of HPLC separation enables improved analysis of F2-isoprostanes by GC-MS. This methodology will assist in defining the role of F2-isoprostanes as in vivo markers of oxidant stress in clinical and experimental settings...
  3. ncbi F2-isoprostanes as biomarkers of lipid peroxidation in patients with chronic renal failure
    Ingrid Wiswedel
    Department of Pathological Biochemistry, University of Magdeburg, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Biofactors 24:201-8. 2005
    ..Furthermore, F2-isoprostanes possess potent biological activities (e.g. 8-iso-PGF2alpha is known as a renal vasoconstrictor) suggesting that they may also act as mediators of the cellular effects of oxidative stress and inflammation...
  4. ncbi Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes
    Michael J Sampson
    Bertram Diabetes Research Unit, Norfolk and Norwich University Hospital National Health Service Trust, Norwich, UK
    Diabetes Care 25:537-41. 2002
    ..Acute hyperglycemia in type 2 diabetes increases the generation of plasma 8-epi-prostaglandin F2 (8-epi-PGF2alpha) isoprostane, a sensitive direct marker of in vivo free radical oxidative damage to membrane phospholipids...
  5. pmc The relationship between dose of vitamin E and suppression of oxidative stress in humans
    L Jackson Roberts
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Free Radic Biol Med 43:1388-93. 2007
    ..This study provides information on the dosage of vitamin E that decreases systemic oxidant stress in vivo in humans and informs the planning and evaluation of clinical studies that assess the efficacy of vitamin E to mitigate disease...
  6. ncbi DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity
    Heno F Lopes
    Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA
    Hypertension 41:422-30. 2003
    ..The findings are consistent with evidence that elevated BP in obese subjects may reflect an imbalance between antioxidant capacity and oxidative stress that is improved by the DASH-CD...
  7. ncbi Benefits of prolonged gradient separation for high-performance liquid chromatography-tandem mass spectrometry quantitation of plasma total 15-series F-isoprostanes
    Alan W Taylor
    Linus Pauling Institute, Oregon State University, Corvallis, 97331, USA
    Anal Biochem 350:41-51. 2006
    ..Ours is the first validated quantitative assay using HPLC-tandem MS applied to plasma total 15-PGFs...
  8. ncbi 8-iso-prostaglandin F2alpha as a marker of tissue oxidative damage in bovine retained placenta
    Marta Kankofer
    Department of Biochemistry, Faculty of Veterinary Medicine, Agricultural University, Lublin, Poland
    Prostaglandins Other Lipid Mediat 70:51-9. 2002
    ..The results indicate that oxidative tissue damage, which may be the result of ROS imbalance, appears during RFM. However, the dynamics of this damage requires further elucidation...
  9. ncbi A mouse model of angiotensin II slow pressor response: role of oxidative stress
    Noritaka Kawada
    Center for Hypertension and Renal Disease Research, Georgetown University Medical Center, 3800 Reservoir Road NE, Washington, DC 20007 2197, USA
    J Am Soc Nephrol 13:2860-8. 2002
    ..There is evidence of increased oxidative stress that is implicated in the increase in the BP and RVR in this model...
  10. ncbi Low-density lipoprotein level reduction by the 3-hydroxy-3-methylglutaryl coenzyme-A inhibitor simvastatin is accompanied by a related reduction of F2-isoprostane formation in hypercholesterolemic subjects: no further effect of vitamin E
    Raffaele De Caterina
    Chair of Cardiology, G D Annunzio University, Chieti, Italy
    Circulation 106:2543-9. 2002
    ..Both statins and vitamin E, by reducing the rate of lipid peroxidation, may interfere with oxidative stress, but the impact of their combination is unknown...
  11. ncbi Antioxidant status of young children: response to an antioxidant supplement
    R J Stewart
    St Luke s Wood River Medical Center, Ketchum, ID, USA
    J Am Diet Assoc 102:1652-7. 2002
    ..To study oxidative stress indicators in healthy young children and their response to a commercially available fruit- and vegetable-based antioxidant supplement...
  12. ncbi Comparison of the antioxidant effects of Concord grape juice flavonoids alpha-tocopherol on markers of oxidative stress in healthy adults
    Dawn J O'Byrne
    Center for Human Nutrition and the Division of Clinical Biochemistry and Human Metabolism, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, USA
    Am J Clin Nutr 76:1367-74. 2002
    ..Concord grape juice (CGJ) is a rich source of flavonoids, which have greater antioxidant efficacy in vitro than does alpha-tocopherol; however, the efficacies of flavonoids and alpha-tocopherol in vivo have not been compared...
  13. ncbi 8-iso-prostaglandin F2alpha as a useful clinical biomarker of oxidative stress in ESRD patients
    Paik Seong Lim
    Department of Nephrology, Kuang Tien General Hospital, 117 Sha Tien Road, Shalu, Taichung 433, Taiwan
    Blood Purif 20:537-42. 2002
    ....
  14. pmc 8-Isoprostaglandin F2a and ascorbic acid concentration in the aqueous humour of patients with exfoliation syndrome
    G G Koliakos
    Department of Biological Chemistry, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Br J Ophthalmol 87:353-6. 2003
    ....
  15. ncbi Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes
    Robert A Jacob
    U S Department of Agriculture ARS Western Human Nutrition Research Center, University of California at Davis, 95616 8683, USA
    J Nutr 133:740-3. 2003
    ..In healthy young men, the endogenous antioxidant defense system and a modest intake of dietary antioxidants are adequate to minimize levels of in vivo oxidant damage such that they cannot be differentiated by current methods...
  16. ncbi Supplementation with vitamin C and N-acetyl-cysteine increases oxidative stress in humans after an acute muscle injury induced by eccentric exercise
    A Childs
    Biochemistry of Aging Laboratory, Center for Exercice Science, College of Human Performance, University of Florida, Gainesville, FL 32611, USA
    Free Radic Biol Med 31:745-53. 2001
    ..This acute human inflammatory model strongly suggests that vitamin C and NAC supplementation immediately post-injury, transiently increases tissue damage and oxidative stress...
  17. ncbi Space flight and oxidative stress
    T P Stein
    Department of Surgery, University of Medicine and Dentistry of New Jersey, School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Nutrition 18:867-71. 2002
    ..Decreasing the imbalance between the production of endogenous oxidant defenses and oxidant production by increasing the supply of dietary antioxidants may lessen the severity of the postflight increase in oxidative stress...
  18. ncbi Propofol (Diprivan-EDTA) counteracts oxidative injury and deterioration of the arterial oxygen tension during experimental septic shock
    S Basu
    Department of Geriatrics and Clinical Nutrition Research, Uppsala University Hospital, S 751 85 Uppsala, Sweden
    Resuscitation 50:341-8. 2001
    ..CONCLUSIONS: Propofol reduced endotoxin-induced free radical mediated and cyclooxygenase catalysed lipid peroxidation significantly. The implication is that propofol counteracts endotoxin-induced deterioration of PaO(2)...
  19. ncbi Prostaglandin F(2alpha) metabolite and F(2)-isoprostane excretion rates in migraine
    Johanna Helmersson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Clin Sci (Lond) 102:39-43. 2002
    ..Our results indicate, however, a lower level of oxidative stress in pre-menopausal compared with post-menopausal women...
  20. ncbi Vitamin E supplementation in the mitigation of carbon tetrachloride induced oxidative stress in rats
    Lesley K MacDonald-Wicks
    Nutrition and Dietetics, School of Health Science, Faculty of Health, University of Newcastle, 2308 Callaghan, NSW, Australia
    J Nutr Biochem 14:211-8. 2003
    ..The results of this study indicate that dl-alpha-tocopherol acetate supplementation was protective of lipid peroxidation when oxidative stress is induced by a pro-oxidant challenge such as CCl4...
  21. ncbi Dietary supplementation with aged garlic extract reduces plasma and urine concentrations of 8-iso-prostaglandin F(2 alpha) in smoking and nonsmoking men and women
    Stephanie A Dillon
    School of Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, England, UK
    J Nutr 132:168-71. 2002
    ..Thus, dietary supplementation with AGE may be useful in reducing oxidative stress in humans...
  22. ncbi Oxidative stress and antioxidant status in type 1 diabetes mellitus
    J Vessby
    Section for Clinical Nutrition Research, Department of Public and Caring Sciences, Uppsala University, Uppsala, Sweden
    J Intern Med 251:69-76. 2002
    ....
  23. ncbi Platelet activation in obese women: role of inflammation and oxidant stress
    Giovanni Davi
    Center of Excellence on Aging, G D Annunzio University Schools of Medicine and Pharmacy, Chieti, Italy
    JAMA 288:2008-14. 2002
    ..Obesity, in particular abdominal adiposity, is associated with increased cardiovascular morbidity and mortality through mechanisms possibly linking the metabolic disorder to platelet and vascular abnormalities...
  24. ncbi Circadian variation in oxidative stress markers in healthy and type II diabetic men
    Eugene L Kanabrocki
    Department of Veteran Affairs, Nuclear Medicine Service, Edward Hines Jr Hospital, Hines, IL 60141, USA
    Chronobiol Int 19:423-39. 2002
    ....
  25. ncbi Oxidative stress in chronic hepatitis C: not just a feature of late stage disease
    Sanjiv K Jain
    The Liver Unit, Manchester Royal Infirmary, Manchester, UK
    J Hepatol 36:805-11. 2002
    ..Chronic hepatitis C infection is a major world-wide problem, frequently progressing to cirrhosis, liver failure or hepatoma. The pathological mechanisms of disease progression are unclear but oxidant stress may play a role...
  26. ncbi Effects of vitamin C and vitamin E on in vivo lipid peroxidation: results of a randomized controlled trial
    Han Yao Huang
    Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore 21205 2223, USA
    Am J Clin Nutr 76:549-55. 2002
    ..Evidence predominantly from in vitro studies suggests that antioxidant vitamins can prevent lipid peroxidation and that vitamin C and vitamin E have synergistic effects. However, in vivo evidence in support of these hypotheses is sparse...
  27. ncbi Lack of effect of oral vitamin C on blood pressure, oxidative stress and endothelial function in Type II diabetes
    D Darko
    Department of Metabolic Medicine, Imperial College School of Medicine, Hammersmith Hospital, London, UK
    Clin Sci (Lond) 103:339-44. 2002
    ..Thus treatment with vitamin C (1.5 g daily) for 3 weeks does not significantly improve oxidative stress, blood pressure or endothelial function in patients with Type II diabetes...
  28. ncbi Oxidant stress is a significant feature of primary biliary cirrhosis
    Ali Aboutwerat
    The Liver Unit, Department of Gastroenterology, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK
    Biochim Biophys Acta 1637:142-50. 2003
    ..This study clearly demonstrates that oxidant stress, as reflected in a comprehensive spectrum of lipid peroxidation and antioxidant markers, is a significant feature of early-stage PBC...
  29. pmc Increased leukotriene B4 and 8-isoprostane in exhaled breath condensate of patients with exacerbations of COPD
    W A Biernacki
    Department of Thoracic Medicine, Imperial College School of Medicine at the National Heart and Lung Institute, Royal Brompton Hospital, London SW3 6LY, UK
    Thorax 58:294-8. 2003
    ..Exacerbations are an important feature of chronic obstructive pulmonary disease (COPD), accounting for a large proportion of health care costs. They are associated with increased airway inflammation and oxidative stress...
  30. ncbi Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease
    Cristina Vassalle
    CNR Institute of Clinical Physiology, Via Moruzzi 1, I 56100 Pisa, Italy
    Coron Artery Dis 14:213-8. 2003
    ..In particular, 8-isoprostane (8-epiPGF(2alpha)) has been indicated as a marker of antioxidant deficiency and oxidative stress of potential relevance to assess human vascular diseases...
  31. ncbi [Analysis of 8-isoprostane concentration as a marker of oxidative stress in pregnant women diagnosed with IUGR]
    Agata Karowicz-Bilinska
    Kliniki Patologii Ciazy Instytutu Ginekologii i Połoznictwa UM w Łodzi
    Ginekol Pol 74:1137-42. 2003
    ..The main aim of the study was to find the correlation between the L-arginine and acetylsalicylic acid therapy and 8-isoprostane concentration...
  32. ncbi [Exhaled breath condensate and its analysis--a new method in pulmonology]
    Geza Vass
    Országos Korányi Tbc és Pulmonológiai Intézet, Kórélettani Osztãly, Budapest
    Orv Hetil 144:2517-24. 2003
    ..The different mediators could help us to know better the diseases, support the diagnosis, follow the treatment or the disease. In this study the authors attempt to present the most important knowledge till now...
  33. ncbi 8-Isoprostane, a marker of oxidative stress, is increased in the expired breath condensate of patients with pulmonary sarcoidosis
    Kostas Psathakis
    Department of Pneumonology, Army General Hospital of Athens, Greece
    Chest 125:1005-11. 2004
    ..Therefore, the aim of our study was to measure the levels of 8-isoprostane in the expired breath condensate of patients with sarcoidosis, and to investigate the relation of 8-isoprostane level to disease activity...
  34. ncbi Increased F2 isoprostane plasma levels in patients with congestive heart failure are correlated with antioxidant status and disease severity
    M Cristina Polidori
    Institute of Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    J Card Fail 10:334-8. 2004
    ....
  35. ncbi Isoprostanes and the kidney
    Kamal F Badr
    Department of Medicine, American University of Beirut, Beirut, Lebanon
    Antioxid Redox Signal 7:236-43. 2005
    ..Here we describe early studies that defined the vasoactive properties of isoprostanes in the kidney, and subsequent discoveries relating to their renal actions and pathophysiologic significance...
  36. ncbi Urinary 8-epi-PGF2alpha and its endogenous beta-oxidation products (2,3-dinor and 2,3-dinor-5,6-dihydro) as biomarkers of total body oxidative stress
    J Nourooz-Zadeh
    Department of Medicine, Royal Free and University College School of Medicine, London, UK
    Biochem Biophys Res Commun 330:731-6. 2005
    ..Simultaneous analysis of urinary 8-epi-PGF2alpha and its metabolites should provide unique tool in clinical trials exploring the role of oxidant injury in human disease...
  37. ncbi Active smoking and a history of smoking are associated with enhanced prostaglandin F(2alpha), interleukin-6 and F2-isoprostane formation in elderly men
    J Helmersson
    Sections of Geriatrics and Clinical Nutrition Research, Department of Public Health and Caring Sciences, Uppsala University, Sweden
    Atherosclerosis 181:201-7. 2005
    ..Subclinical COX- and cytokine-mediated inflammation and oxidative stress are ongoing processes not only in active smokers but also in former smokers which may contribute to the accelerated atherosclerosis associated with smoking...
  38. ncbi Biomarkers of oxidative stress and antioxidant status in children born small for gestational age: evidence of lipid peroxidation
    Maria C P Franco
    Division of Nephrology, School of Medicine, Federal University of Sao Paulo, 04023 900 São Paulo, Brazil
    Pediatr Res 62:204-8. 2007
    ..In conclusion, the current study revealed that there is evidence of oxidative stress in children born small for gestational age as supported by increased lipid peroxidation...
  39. ncbi Biomarkers for oxidative stress: measurement, validation, and application
    Etsuo Niki
    National Institute of Advanced Industrial Science and Technology, Human Stress Signal Research Center, Osaka, Japan
    J Med Invest 52:228-30. 2005
    ..Total hydroxyoctadecadienoic acid (HODE) and 7-hydroxycholesterol measured after reduction and saponification of biological fluids may be used as reliable biomarker...
  40. ncbi Iron and 8-isoprostane levels in acute and chronic wounds
    Sim Yeoh-Ellerton
    University of Western Australia, Department of Surgery, Fremantle Hospital, Australia
    J Invest Dermatol 121:918-25. 2003
    ..001). These results suggest the existence of an environment of oxidative stress in chronic wounds and the likely contribution of iron to exacerbating tissue damage and delaying healing in these wounds...
  41. ncbi Effects of bezafibrate and simvastatin on endothelial activation and lipid peroxidation in hypercholesterolemia: evidence of different vascular protection by different lipid-lowering treatments
    Giovambattista Desideri
    Department of Internal Medicine and Public Health, University of L Aquila, 67100 Coppito L Aquila, Italy
    J Clin Endocrinol Metab 88:5341-7. 2003
    ..Thus, a different vascular protection can be achieved by different lipid-lowering treatments...
  42. pmc A dose-response study on the effects of purified lycopene supplementation on biomarkers of oxidative stress
    Sridevi Devaraj
    Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, 4635 2nd Avenue, Sacramento, CA 95817, USA
    J Am Coll Nutr 27:267-73. 2008
    ..Thus, we tested the effects of different doses of purified lycopene supplementation on biomarkers of oxidative stress in healthy volunteers...
  43. ncbi Effect of losartan on oxidative stress-induced hypertension in Sprague-Dawley rats
    Mohamed A Bayorh
    Department of Pharmacology and Toxicology, Morehouse School of Medicine, Atlanta, Georgia 30310 1495, USA
    Am J Hypertens 16:387-92. 2003
    ....
  44. ncbi Increased renal medullary H2O2 leads to hypertension
    Ayako Makino
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Hypertension 42:25-30. 2003
    ....
  45. ncbi Effect of vitamin E and eccentric exercise on selected biomarkers of oxidative stress in young and elderly men
    Jennifer M Sacheck
    Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Tufts University, Boston, MA 02111, USA
    Free Radic Biol Med 34:1575-88. 2003
    ....
  46. ncbi Uric acid reduces exercise-induced oxidative stress in healthy adults
    W S Waring
    Clinical Pharmacology Unit and Research Centre, University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, Scotland, UK
    Clin Sci (Lond) 105:425-30. 2003
    ..These findings indicate that the antioxidant properties of UA are of biological importance in vivo...
  47. ncbi Enhanced lipid peroxidation and platelet activation in the early phase of type 1 diabetes mellitus: role of interleukin-6 and disease duration
    Giovanni Davi
    Center of Excellence on Aging and Department of Medicine, University of Chieti G d Annunzio Schools of Medicine and Pharmacy, Chieti, Italy
    Circulation 107:3199-203. 2003
    ..We also investigated the relationship between inflammatory markers and F2-isoprostane formation in this setting...
  48. ncbi Isoprostanes: are they more than physiopathological biomarkers of lipid peroxidation?
    Jean Luc Cracowski
    Circulation 107:e222; author reply e222. 2003
  49. ncbi Lipid and protein oxidation contribute to a prothrombotic state in patients with type 2 diabetes mellitus
    R De Cristofaro
    Center of Excellence on Aging, G D Annunziou University School of Medicine and Pharmacy, Chieti, Italy
    J Thromb Haemost 1:250-6. 2003
    ..In conclusion, OS in T2DM involves circulating proteins and is associated with an unbalanced promotion of procoagulant reactions. These effects in concert with platelet activation may contribute to atherothrombotic complications in T2DM...
  50. ncbi Vitamin C supplementation decreases oxidative stress biomarker f2-isoprostanes in plasma of nonsmokers exposed to environmental tobacco smoke
    Marion Dietrich
    School of Public Health, University of California Berkeley, 140 Warren Hall, Berkeley, CA 94720 7360, USA
    Nutr Cancer 45:176-84. 2003
    ..Daily AO supplementation (especially with vitamin C) decreases this oxidative stress biomarker in passive smokers. This finding might be of importance for the prevention of ETS-associated adverse health effects in nonsmokers...
  51. ncbi Protective activity of tomato products on in vivo markers of lipid oxidation
    Francesco Visioli
    Department of Pharmacological Science, University of Milan, Via Balzaretti 9, 20133, Milano, Italy
    Eur J Nutr 42:201-6. 2003
    ..It has been suggested that regular consumption of tomato products improves antioxidant defenses due to their endogenous antioxidant compounds, notably lycopene...
  52. ncbi Clinical oxidation parameters of aging
    Peter Voss
    Research Institute for Environmental Medicine, Molecular Aging Research, Heinrich Heine University Duesseldorf, D 40225, Duesseldorf, Germany
    Free Radic Res 40:1339-49. 2006
    ..This set should include at least one marker for the LPO, the protein oxidation and the total antioxidative status and ideally also one for DNA damages...
  53. pmc Human tear lipocalin acts as an oxidative-stress-induced scavenger of potentially harmful lipid peroxidation products in a cell culture system
    M Lechner
    , , Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria
    Biochem J 356:129-35. 2001
    ..These results support the idea that lcn-1 acts as a physiological scavenger of potentially harmful lipophilic molecules; lcn-1 might therefore be a novel member of the cellular defence against the deleterious effects of oxidative stress...
  54. ncbi Chronic aminoguanidine attenuates renal dysfunction and injury in aging rats
    J F Reckelhoff
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505, USA
    Am J Hypertens 12:492-8. 1999
    ..These findings suggest that aminoguanidine attenuates aging renal dysfunction by inhibiting a pathophysiologic function of iNOS that is independent of free radical-mediated lipid peroxidation or significant effects on AGE deposition...
  55. ncbi Oxidative stress and antioxidant status in fetal circulation in preeclampsia
    Kristin Braekke
    Department of Pediatric Intensive Care, Ulleval University Hospital, 0407 Oslo, Norway
    Pediatr Res 60:560-4. 2006
    ..In conclusion, no evidence of increased oxidative stress, evaluated by 8-isoprostane concentration, was found in fetal circulation in preeclampsia...
  56. ncbi Lipid peroxidation is increased in paraoxonase L55 homozygotes compared with M-allele carriers
    R Malin
    Tampere University Hospital, Centre for Laboratory Medicine, Department of Clinical Chemistry and University of Tampere, Medical School; P.O. Box 2000, 33521 Tampere, Finland
    Free Radic Res 34:477-84. 2001
    ..PON may thus protect against oxidative stress by destroying some biologically active lipids. Excretion of 8-iso-PGF(2alpha) is increased in type 2 diabetes, which may reflect oxidant injury...
  57. ncbi Oxidative stress in cystic fibrosis: dietary and metabolic factors
    L G Wood
    Discipline of Nutrition and Dietetics, University of Newcastle, Callaghan, New South Wales, Australia
    J Am Coll Nutr 20:157-65. 2001
    ..The immune response appears to be a key factor causing oxidative stress. Antioxidant intervention aimed at reducing oxidative stress in CF needs to be assessed...
  58. ncbi Increase of isoprostane 8-epi-PGF(2alpha)after restarting smoking
    F Chehne
    Department of Nuclear Medicine, University of Vienna, A-1090 Vienna, Austria
    Prostaglandins Leukot Essent Fatty Acids 64:307-10. 2001
    ..These data indicate a fast response of restarting as on quitting smoking on in vivo oxidation injury. The oxidation injury reflected by 8-epi-PGF(2alpha)may be a key pathogenetic mechanism in smoking-induced vascular injury...
  59. ncbi Human halothane metabolism, lipid peroxidation, and cytochromes P(450)2A6 and P(450)3A4
    E D Kharasch
    Department of Anesthesiology, University of Washington, Seattle 98195, USA
    Eur J Clin Pharmacol 55:853-9. 2000
    ..This investigation tested the hypotheses that halothane causes lipid peroxidation in humans in vivo, and that CYP2A6 or CYP3A4 inhibition can diminish halothane metabolism...
  60. ncbi Effect of the isoprostanes, 8-iso prostaglandin E2 and 8-iso prostaglandin F2 alpha on the rabbit lung in vivo
    A A Hill
    Department of Clinical Pharmacology, RPMS, Hammersmith Hospital, London
    Prostaglandins 53:69-82. 1997
    ..We conclude that the aerosolised isoprostanes are not broncho-constricting agents in the rabbit in vivo...
  61. ncbi A prospective, randomized clinical trial to compare the effect of hyperbaric to normobaric hyperoxia on cerebral metabolism, intracranial pressure, and oxygen toxicity in severe traumatic brain injury
    Sarah B Rockswold
    Department of Physical Medicine and Rehabilitation, Hennepin County Medical Center, Minneapolis, Minnesota 55415, USA
    J Neurosurg 112:1080-94. 2010
    ..Hyperoxia can be delivered to the brain under normobaric as well as hyperbaric conditions. In this study the authors directly compare hyperbaric oxygen (HBO2) and normobaric hyperoxia (NBH) treatment effects...
  62. ncbi The influence of isoprostanes on ADP-induced platelet aggregation and cyclic AMP-generation in human platelets
    N Leitinger
    Department of Nuclear Medicine, University of Vienna, Austria
    Thromb Res 86:337-42. 1997
    ..In this study we investigate possible pro- or antiaggregatory properties of various F- and E-type isoprostanes on human platelets...
  63. ncbi Insulin sensitivity and cardiovascular risk factors in ovariectomized monkeys with estradiol alone or combined with nomegestrol acetate
    J D Wagner
    Department of Comparative Medicine, Bowman Gray School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Clin Endocrinol Metab 83:896-901. 1998
    ..In conclusion, NA, a progestin without androgenic activity, may still affect some cardiovascular risk factors differently than estrogen-only therapy. However, it seems to be less detrimental than MPA...
  64. ncbi Cold storage induces time-dependent F2-isoprostane formation in renal tubular cells and rat kidneys
    A Salahudeen
    Department of Medicine, University of Mississippi Medical Center, Jackson, USA
    Kidney Int 55:1759-62. 1999
    ..Because free radical-induced lipid peroxidation catalyzes the cyclooxygenase-independent formation of vasoconstrictive F2-isoprostanes, the hypothesis that isoprostanes are produced during cold storage was tested in this study...
  65. ncbi In vivo oxidative damage in rats is associated with barbiturate response but not other cytochrome P450 inducers
    Miroslav Dostalek
    Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232 0146, USA
    Mol Pharmacol 72:1419-24. 2007
    ..These studies define the contribution of P450s to oxidative stress in vivo, in that the phenomenon is relatively restricted and most P450s do not contribute substantially...
  66. ncbi Platelet activation and lipid peroxidation in patients with acute ischemic stroke
    F van Kooten
    Department of Neurology, University Hospital Rotterdam, Netherlands
    Stroke 28:1557-63. 1997
    ....
  67. ncbi Prostanoid and TP-receptors in atherothrombosis: is there a role for their antagonism?
    Chiara Giannarelli
    Atherothrombosis Research Unit, Cardiovascular Institute, Mount Sinai School of Medicine, New York, New York 10029, USA
    Thromb Haemost 104:949-54. 2010
    ....
  68. ncbi Maternal cigarette smoking increases F2-isoprostanes and reduces prostacyclin and nitric oxide in umbilical vessels
    R Obwegeser
    Department of Obstetrics and Gynecology, University Hospital Vienna, Austria
    Prostaglandins Other Lipid Mediat 57:269-79. 1999
    ..We suggest that smoking might enhance the vasoconstrictory capacity in umbilical arteries by increased F2-isoprostanes and by a simultaneous decrease in the production of the vasodilatory compounds, prostacyclin, and nitric oxide...
  69. ncbi Increase in alveolar antioxidant levels in hyperoxic and anoxic ventilated rabbit lungs during ischemia
    Reinhold Schmidt
    Medizinische Klinik II, Zentrum fur Innere Medizin, Justus Liebig University, Giessen, Germany
    Free Radic Biol Med 36:78-89. 2004
    ..This is paralleled by an increase rather than a decrease in alveolar antioxidant levels, suggested to reflect an adaptive response to oxidative stress during ischemia...
  70. ncbi Anticholinesterase toxicity and oxidative stress
    Dejan Milatovic
    Department of Pediatrics, Medical School, Vanderbilt University, Nashville, TN, USA
    ScientificWorldJournal 6:295-310. 2006
    ..This review describes the mechanisms involved in anticholinesterase-induced oxidative/nitrosative injury in target organs of OPs/CMs, and protection by various agents...
  71. pmc Therapeutic hypothermia preserves antioxidant defenses after severe traumatic brain injury in infants and children
    Hulya Bayir
    Safar Center for Resuscitation Research, Children s Hospital of Pittsburgh, Pittsburgh, PA, USA
    Crit Care Med 37:689-95. 2009
    ..Our objective was to determine the effect of therapeutic hypothermia on oxidative damage after severe TBI in infants and children randomized to moderate hypothermia vs. normothermia...
  72. ncbi Oxidative stress, isoprostanes and hepatic fibrosis
    Mario Comporti
    Department of Pathophysiology, Experimental Medicine and Public Health, University of Siena, Italy
    Histol Histopathol 24:893-900. 2009
    ..Immunocytochemical studies showed the major localization of TxA2r in the perinuclear site and its colocalization with alpha-smooth muscle actin...
  73. ncbi The effect of N-acetylcysteine on renal function, nitric oxide, and oxidative stress after angiography
    Shai Efrati
    Department of Medicine A, Division of Cardiology, Asaf Harofeh Medical Center, Zerifin, Israel
    Kidney Int 64:2182-7. 2003
    ..We examined the hypothesis that NAC protected against contrast-induced renal impairment through effects on nitric oxide metabolism and oxidative stress...
  74. ncbi 8-Isoprostaglandin F2 alpha, a product of lipid peroxidation, increases portal pressure in normal and cirrhotic rats
    R Marley
    Department of Academic Medicine, Royal Free Hospital School of Medicine, London, England
    Gastroenterology 112:208-13. 1997
    ..If extrapolated to patients with cirrhosis, lipid peroxidation secondary to alcoholic liver injury, sepsis, or other liver pathology may cause an acute increase in portal pressure such as that observed in acute liver injury...
  75. ncbi Measurement of plasma F2-isoprostanes as an index of lipid peroxidation does not appear to be confounded by diet
    N K Gopaul
    The William Harvey Research Institute, St Bartholomew s and the Royal London School of Medicine and Dentistry, UK
    Free Radic Res 33:115-27. 2000
    ....
  76. ncbi Release of the lipid peroxidation marker 8-epi-prostaglandin F2 alpha from isolated gill pavement cells
    Eric G Spokas
    Department of Chemistry and Biochemistry, Rider University, Lawrenceville, New Jersey 08648 3099, USA
    Environ Toxicol Chem 27:1569-75. 2008
    ..In summary, F2-iP release occurs during lipid peroxidation injury to fish gill epithelium, and its measurement may facilitate aquatic toxicology studies of metallic and nonmetallic contaminants...
  77. ncbi [Study of oxidative stress in advanced kidney disease]
    M J Puchades Montesa
    Servicio de Nefrologia, Hospital Clinico Universitario de Valencia, Valencia, Spain
    Nefrologia 29:464-73. 2009
    ..The aim of this study was to asses the oxidation of the main molecular lines in patients with advanced renal disease without dialysis and to determinate the best biomarker to asses this stress...
  78. ncbi Docosahexaenoic acid restores endothelial function in children with hyperlipidemia: results from the EARLY study
    M M Engler
    University of California, San Francisco, San Francisco, CA 94143 0610, USA
    Int J Clin Pharmacol Ther 42:672-9. 2004
    ....
  79. ncbi Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha
    P Kunapuli
    Center for Experimental Therapeutics, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 272:27147-54. 1997
    ..Four additional F2 isoprostanes, 8-iso-PGF2alpha, IPF2alpha-I, IPF2alpha-III, and 9beta,11beta-PGF2, caused trivial, or no, activation of the ..
  80. ncbi Antioxidant susceptibility of pathogenic pathways in subjects with antiphospholipid antibodies: a pilot study
    P R Ames
    Coagulation Unit, Cardarelli Hospital, Naples, Italy
    Lupus 9:688-95. 2000
    ..01) and albuminuria (P = 0.01) in aPL participants but not in controls. These pilot data support oxidative sensitive mechanisms and a potential role for antioxidant treatment in the pathogenesis of aPL induced vasculopathy...
  81. ncbi Cyclo-oxygenase-1 and -2 differently contribute to prostaglandin E2 synthesis and lipid peroxidation after in vivo activation of N-methyl-D-aspartate receptors in rat hippocampus
    Olimpia Pepicelli
    Department of Cell Biology and Neurosciences, Istituto Superiore di Sanita, Rome, Italy
    J Neurochem 93:1561-7. 2005
    ..We suggest that both isoforms should be considered as possible therapeutic targets to prevent brain damage caused by excitotoxicity...
  82. ncbi Knockout of cellular glutathione peroxidase gene renders mice susceptible to diquat-induced oxidative stress
    Y Fu
    Department of Animal Science, Cornell University, Ithaca, NY 14853, USA
    Free Radic Biol Med 27:605-11. 1999
    ..Responses of hepatic superoxide dismutase activities to the diquat treatment were affected by the GPX1 level. In conclusion, GPX1 is the major selenoprotein to protect mice against the lethal oxidative stress induced by diquat...
  83. ncbi Effect of selenium supplementation on biochemical markers and outcome in critically ill patients
    Vinita Mishra
    Department of Clinical Chemistry, Royal Liverpool University Hospital, Liverpool L69 3GA, UK
    Clin Nutr 26:41-50. 2007
    ....
  84. ncbi Enhanced zinc consumption prevents cadmium-induced alterations in lipid metabolism in male rats
    Joanna Rogalska
    Department of Toxicology, Medical University of Bialystok, Mickiewicza 2c, 15 222 Bialystok, Poland
    Chem Biol Interact 177:142-52. 2009
    ..The paper is the first report suggesting protective impact of Zn against proatherogenic Cd action on experimental model of chronic moderate and relatively high human exposure to this toxic metal...
  85. ncbi Elevated plasma F2-isoprostanes in patients on long-term hemodialysis
    G J Handelman
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Kidney Int 59:1960-6. 2001
    ..Plasma F2-isoprostanes have been established as an important indicator of in vivo oxidative stress...
  86. ncbi Oxidant stress and peripheral neuropathy during antiretroviral therapy: an AIDS clinical trials group study
    Todd Hulgan
    Vanderbilt University School of Medicine, Nashville, TN 37203, USA
    J Acquir Immune Defic Syndr 42:450-4. 2006
    ..Mitochondria play a central role in regulating oxidant stress. We explored the relationships between oxidant stress and NRTI-induced peripheral neuropathy...
  87. ncbi 8-Epi-PGF2 alpha, a novel noncyclooxygenase-derived prostaglandin, constricts airways in vitro
    I Kawikova
    Department of Thoracic Medicine, National Heart and Lung Institute, London, United Kingdom
    Am J Respir Crit Care Med 153:590-6. 1996
    ..However, if 8-epi-PGF2 alpha is formed in asthma, its production, unlike that of other prostanoids, would not be inhibited by cyclooxygenase inhibitors...
  88. ncbi Identification and measurement of endogenous beta-oxidation metabolites of 8-epi-Prostaglandin F2alpha
    C Chiabrando
    Department of Environmental Health Sciences, Via Eritrea 62, 20157 Milano, Italy
    J Biol Chem 274:1313-9. 1999
    ..In conclusion, at least two major beta-oxidation products of 8-epi-PGF2alpha are present in urine, which may be considered as additional analytical targets to evaluate 8-epi-PGF2alpha formation and degradation in vivo...
  89. ncbi F2-isoprostane generation in isolated ferret lungs after oxidant injury or ventilated ischemia
    P M Becker
    The Johns Hopkins University School of Medicine, Department of Medicine, Baltimore, MD, USA
    Free Radic Biol Med 25:703-11. 1998
    ..These results suggest that tissue levels of F2-isoprostanes reflect lung lipid peroxidation, but that F2-isoprostane generation does not directly increase vascular permeability following ventilated pulmonary ischemia...
  90. ncbi Streamlined F2-isoprostane analysis in plasma and urine with high-performance liquid chromatography and gas chromatography/mass spectroscopy
    M F Walter
    Antioxidants Research Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts 02111, USA
    Anal Biochem 280:73-9. 2000
    ..1-fold higher in a cigarette smoker than respective control subjects. This method, particularly the substitution of the TLC step common to other methods with HPLC, results in a more sensitive and reproducible assay...
  91. ncbi Isoflavonoids do not inhibit in vivo lipid peroxidation in subjects with high-normal blood pressure
    J M Hodgson
    University of Western Australia Department of Medicine and the Western Australian Heart Research Institute, Royal Perth Hospital, Australia
    Atherosclerosis 145:167-72. 1999
    ..These results are not consistent with the suggestion that the two soy derived isoflavonoids have in vivo antioxidant activity at a level of intake achievable by dietary means and in subjects with high-normal BP...
  92. ncbi Mechanism and prevention of cold storage-induced human renal tubular cell injury
    A K Salahudeen
    Department of Medicine, University of Mississippi Medical Center, Jackson 39216 4505, USA
    Transplantation 70:1424-31. 2000
    ..The objective was, therefore, to seek direct evidence for the free radical production during the cold storage of human renal tubular cells, and to define the roles of extrinsic and intrinsic antioxidants in cold-induced cell injury...
  93. ncbi Formation of isoprostanes in children with type IIa hypercholesterolemia
    J L Cracowski
    Laboratory of Pharmacology, Grenoble University Hospital, France
    J Cardiovasc Pharmacol 38:228-31. 2001
    ....
  94. ncbi Assessment of oxidant stress in allergic asthma by measurement of the major urinary metabolite of F2-isoprostane, 15-F2t-IsoP (8-iso-PGF2alpha)
    R Dworski
    Department of Critical Care Medicine, Vanderbilt University School of Medicine, T 1217 MCN, Nashville, TN 37232 2650, USA
    Clin Exp Allergy 31:387-90. 2001
    ..No increase in the urinary excretion of 15-F2t-IsoP-M occurred after inhalation of methacholine. Allergen challenge causes an oxidant injury in human atopic asthmatics. 15-F2t-IsoP-M is a valuable marker of oxidant stress in vivo...
  95. ncbi The response of muscle interstitial F2-isoprostane (8-ISO-PGF2alpha) during dynamic muscle contractions in humans
    I Karamouzis
    Ergophysiology Laboratory, Department of Physical Education and Sports Science, Aristotle University of Thessaloniki, Thessaloniki, Greece
    Prostaglandins Leukot Essent Fatty Acids 71:87-90. 2004
    ..The microdialysis method is widely applied, easily repeated and it could contribute in evaluating the local lipid muscle peroxidation during intensive exercise...
  96. ncbi [Isoprostanes: new markers of oxidative stress in human diseases]
    J L Cracowski
    Laboratoire de Pharmacologie, Faculte de Medecine de Grenoble, La Tronche
    Presse Med 29:604-10. 2000
    ....
  97. ncbi F2 isoprostane levels in plasma and urine do not support increased lipid peroxidation in cognitively impaired Parkinson disease patients
    James Connolly
    Department of Neurology, Parkinson s Disease and Movement Disorders Center, Pennsylvania Hospital, Philadelphia, PA 19107, USA
    Cogn Behav Neurol 21:83-6. 2008
    ..To determine the utility of 8,12-isoprostaneF2alpha-VI (iP), a specific and sensitive index of lipid peroxidation, as a biomarker for dementia in Parkinson disease (PD)...
  98. ncbi Immunological and metabolic effects of cis-9, trans-11-conjugated linoleic acid in subjects with birch pollen allergy
    Anu M Turpeinen
    Department of Applied Chemistry and Microbiology Nutrition, University of Helsinki, PO Box 66, Helsinki 00014, Finland
    Br J Nutr 100:112-9. 2008
    ..01), and 15-keto-dihydro-PGF2alpha, a primary PGF2alpha metabolite (P < 0.05), increased in the CLA group. The results suggest that cis-9, trans-11-CLA has modest anti-inflammatory effects in allergic subjects...
  99. ncbi Effects of the phytoestrogen genistein on some predictors of cardiovascular risk in osteopenic, postmenopausal women: a two-year randomized, double-blind, placebo-controlled study
    Marco Atteritano
    Department of Internal Medicine, University of Messina, Italy
    J Clin Endocrinol Metab 92:3068-75. 2007
    ..Genistein, a soy isoflavone, has received wide attention over the last few years because of its potential preventive role for cardiovascular disease...
  100. pmc Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease
    Aynun N Begum
    Department of Medicine, University of California, Los Angeles, California, USA
    J Pharmacol Exp Ther 326:196-208. 2008
    ..were similar, correlating with reduction in LPS-stimulated inducible nitric-oxide synthase, nitrotyrosine, F2 isoprostanes, and carbonyls...
  101. ncbi F4-isoprostanes: a novel class of prostanoids formed during peroxidation of docosahexaenoic acid (DHA)
    J Nourooz-Zadeh
    Centre for Clinical Pharmacology and Therapeutic Toxicology, Department of Medicine, London, England
    Biochem Biophys Res Commun 242:338-44. 1998
    ..The possibility of analyzing F4-isoprostanes should provide new opportunities for studying the role of lipid peroxidation in nutritional studies and in the pathogenesis of neurodegenerative diseases...

Research Grants63

  1. Mitochondrial dysfunction, oxidative stress, and surgical acute kidney injury
    FREDERIC TREMAINE BILLINGS; Fiscal Year: 2013
    ..Strong institutional investment in the candidate optimizes his likelihood of progressing to independence and impacting on adverse effects of surgery. ..
  2. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David Jacobs; Fiscal Year: 2009
    ..abstract_text> ..
  3. EPIDEMIOLOGY: OXIDATIVE STRESS AND EARLY ATHEROSCLEROSIS
    David R Jacobs; Fiscal Year: 2013
    ....
  4. Green Tea and Reduction of Breast Cancer Risk
    MINDY SUSAN KURZER; Fiscal Year: 2013
    ..The development of a viable non-toxic chemoprevention strategy targeting high risk women could have a significant impact on breast cancer morbidity and mortality. ..
  5. The influence of selenium on biomarkers of prostate cancer risk
    KARAM E EL-BAYOUMY; Fiscal Year: 2012
    ..Collectively, studies proposed here are essential to the control and prevention of PC in men. ..
  6. Using Mass Spectroscopy to Characterize Transcription Proteins and F2-Isoprostane
    BETTYE HENNINTON; Fiscal Year: 2011
    ..Revealing a part of the story of the regulation of Gcr1 p could yield insight into MLLS's role in this disease. ..
  7. Functional roles of Nrf2 and NQO1 genetic variants in hyperoxic lung injury-ARDS
    Bhagavatula Moorthy; Fiscal Year: 2013
    ..g., use of PPI such as OM) for the prevention/treatment of ALI/ARDS in humans. ..
  8. Targeted investigation of tissue specific oxidative stress in the etiology of ALS
    Holly Van Remmen; Fiscal Year: 2013
    ....
  9. Role of cytochrome P4501B1 in oxygen-mediated pulmonary injury
    Bhagavatula Moorthy; Fiscal Year: 2013
    ..This project is aimed at developing novel strategies for the prevention/treatment of lung diseases such as BPD and ARDS in humans. ..
  10. An Integrated Study of Mitochondrial Pathways in Colorectal Cancer
    Bharat Thyagarajan; Fiscal Year: 2013
    ....
  11. Prenatal diet, PM2.5 and programming of the infant autonomic response
    Rosalind J Wright; Fiscal Year: 2013
    ....
  12. Multi-Dimensional Successful Aging Among HIV-Infected Adults
    David J Moore; Fiscal Year: 2013
    ..Understanding potentially malleable protective versus risk factors at an individual level may lead to development of new interventions aimed at increasing the likelihood of successful aging among people living with HIV. ..
  13. Long-Chain Fatty Acids, Oxidative Stress and Colorectal Neoplasm Risk
    Harvey J Murff; Fiscal Year: 2013
    ..The purpose of this study is to determine if omega-3 fatty acids reduce the risk of colorectal adenomas and diminishes the production of inflammatory and oxidative stress biomarkers. ..
  14. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..be studied based on our preliminary and published data include: hemoglobin which alters platelet function;F2 isoprostanes that are markers of oxidative stress and cell damage and directly affect platelet function;and red cell-..
  15. Mechanisms for Benzo(a)pyrene-Induced Colon Cancer Exacerbation by Dietary Fat
    Aramandla Ramesh; Fiscal Year: 2013
    ..Our findings will serve as a prelude to conducting chemoprevention studies for CRC and help to synthesize drugs to prevent or delay the onset of colon cancer. ..
  16. Weight Loss &Cancer Biomarkers in Women: 0xidative Stress &Inflammation
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..The results of this novel study will elucidate potential mechanisms linking energy balance to cancer in women, which will aid in the development of interventions for reducing risk for several cancers. ..
  17. Biomarkers of Obesity, Prostate Tissue Inflammation, and BPH Progression
    Jay H Fowke; Fiscal Year: 2013
    ..Results may argue for one of several plausible interventions targeting obesity, inflammation, or oxidative stress to delay BPH progression. ..
  18. Accelerated Biological Aging in Schizophrenia
    Gregory A Light; Fiscal Year: 2013
    ..Discovering whether accelerated biological aging occurs in SZ and understanding the underlying mechanisms should lead to new ways of predicting, tracking, and treating the serious medical co-morbidities commonly seen in this population. ..
  19. Increased Plasma Nitrite, Tissue Oxygenation and Functional Changes in PAD
    Jason David Allen; Fiscal Year: 2013
    ....
  20. STRUCTURAL IDENTIFICATION OF PROSTAGLANDIN CONJUGATES
    L Jackson Roberts; Fiscal Year: 2010
    ..Finally, we will test the hypothesis that free radicals and IsoPs play an important role in the renal failure that ensues in glactosamine treated rats, an animal model of the hepatorenal syndrome. ..
  21. Mechanisms for Dysfunctional HDL Formation in Familial Hypercholesterolemia
    Macrae F Linton; Fiscal Year: 2013
    ..Our results may lead to the development of new markers of HDL function, provide new pharmacologic targets for improving HDL function, and identify HDL as a target of therapy in FH patients. ..
  22. Inflammatory Biomarkers and Colorectal Cancer Risk
    Gong Yang; Fiscal Year: 2010
    ..Overall, this study will contribute significantly to the understanding of the role of inflammation in the etiology of CRC and to the development of new strategies for the assessment of CRC risk. ..
  23. Oxidative Stress and Anti-Inflammatory Lipids in Airway Disease
    Bruce D Levy; Fiscal Year: 2010
    ..In this proposal, we seek to develop a better understanding of the natural biological processes invoked during airway infection and inflammation that dysregulate the natural homeostatic mechanisms. (End of Abstract) ..
  24. Hemolysis, Lipid Oxidation and Vascular Dysfunction in Sickle Cell Disease
    TIMOTHY CHARLES FLEWELEN; Fiscal Year: 2012
    ..When completed, this research should lead to the discovery and exploitation of a new therapeutic target to aid in the treatment of sickle cell disease. ..
  25. A platform for individualized nutritional therapy in Alzheimer's disease
    Gene L Bowman; Fiscal Year: 2012
    ..The nutrient parameters to be studied include homocysteine and its determinants, antioxidants and F2 Isoprostanes as a marker of oxidative stress, the omega 3 fatty acids docosahexaenoic acid and eicosapentaenoic acid, and ..
  26. QUESTIONABLE DEMENTIA: COURSE AND PREDICTORS OF OUTCOME
    Davangere P Devanand; Fiscal Year: 2012
    ..Accurate prediction of MCI conversion to AD will help identify patients who need early treatment, facilitate patient/family planning for their own future, and improve patient selection for clinical trials. ..
  27. Neuroprotectins and Maresins for Macrophages in Diabetic Wound Healing
    Song Hong; Fiscal Year: 2013
    ..These mechanisms may be potential targets for developing therapeutical strategies to cure the nonhealing of diabetes-impaired wounds. ..
  28. Exhaled NO and Oxidative Stress in Systemic Sclerosis Pulmonary Hypertension
    Paul M Hassoun; Fiscal Year: 2012
    ..By providing mechanistic insights, this research may also serve as a basis for the testing of novel therapeutic classes, such as anti-oxidants and/or NO donors. ..
  29. Gastrin-Releasing Peptide and Bronchopulmonary Dysplasia
    Judith A Voynow; Fiscal Year: 2013
    ..Aim 2: To determine whether reactive oxygen species (indicated by elevated urinary F2-isoprostane metabolites, 8-hydroxy-2'-deoxyguanosine, allantoin) directly correlate with increased GRP. ..
  30. NRF2 Anti-Oxidant Systems and White Matter Hyperintensities
    Frank R Sharp; Fiscal Year: 2013
    ..It will also begin to provide the rationale and preliminary data needed before antioxidant trials would be undertaken to reduce WMH with the goal of delaying or preventing cognitive decline. ..
  31. Non-Invasive Quantitation of Cellular and Biochemical Changes in Hereditary Ataxi
    GULIN OZ; Fiscal Year: 2009
    ..Successful application of such treatments is expected to reduce the burden caused by these diseases on individuals, their families and society. ..
  32. Fatty Acids, Angiotensin and Oxidative Stress
    Brent Egan; Fiscal Year: 2004
    ..We believe the information generated by the proposed studies has the potential for elucidating biological mechanisms underlying obesity-associated hypertension and the potential for dietary anti-oxidants to modulate BP. ..
  33. OXIDATIVE STRESS IN SEIZURE INDUCED NEURONAL INJURY
    WOLF DIETRICH DETTBARN; Fiscal Year: 1999
    ..as DFP and KA produce seizure-induce neuronal necrosis via ROS-induced lipid peroxidation and generation of F2 isoprostanes. As such, these studies will provide fundamental new insights into the molecular events underlying oxidant-..
  34. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2007
    ..This study could have enormous public health significance, because supplementation with antioxidant nutrients would be an inexpensive and practicable means to reduce morbidity and mortality from pulmonary disease. ..
  35. ALCOHOL-INDUCED HEPATIC P450s IN HCV/HIV OXIDATE INJURY
    STEVEN SHEDLOFSKY; Fiscal Year: 2003
    ..These studies will define the role of P450s in the alcohol enhancement of HCV liver injury and might suggest P450 inhibitors as therapies for HCV infected individuals even if they continue to drink alcohol. ..
  36. Molecular mechanisms of cytochrome P4501A regulation by hyperoxia
    Bhagavatula Moorthy; Fiscal Year: 2010
    ..Using animal and cell culture models, this project is aimed at developing rational strategies for the prevention and treatment of lung diseases (e.g. BPD and ARDS) associated with hyperoxia. ..
  37. ISOPROSTANES IN LIVER DISEASE-INDUCED RENAL DYSFUNCTION
    Luis Juncos; Fiscal Year: 2004
    ..Our proposed application therefore characterizes the renal vascular actions of oxidative stress and isoprostanes, and evaluates their role in the c-BDL rats. ..
  38. Liver Fibrosis, Inflammation & Oxidative Stress Markers
    Charles Lieber; Fiscal Year: 2006
    ..abstract_text> ..
  39. Protective Efficacy of Mg-Supplementation Against NRTI-induced Cardiac Toxicity
    IVAN MAK; Fiscal Year: 2007
    ..This proposed exploratory effort may reveal a potential usefulness of Mg-supplements as an effective, yet relatively inexpensive adjunct therapy to lessen NRTI-related cardiovascular toxicity. ..
  40. Age, gender and skeletal muscle microcirculation
    LEAH HAMMER; Fiscal Year: 2004
    ..The data generated from this proposal will enhance our knowledge of changes in skeletal muscle microcirculation function with aging and will broaden our understanding of gender difference in cardiovascular function. ..
  41. Oxidant Stress and Antioxidants during HIV Therapy
    Todd Hulgan; Fiscal Year: 2007
    ..The candidate's long-term goal is to develop into an independent clinical investigator in this field of study. ..
  42. CLINICAL STUDIES IN NUTRITION AND METABOLISM
    Ishwarlal Jialal; Fiscal Year: 2009
    ....
  43. ADENOSINE 3 RECEPTOR AGONIST FOR TREATMENT OF COLITIS
    Andrew Salzman; Fiscal Year: 2000
    ..PROPOSED COMMERCIAL APPLICATIONS: The market for a safe and effective novel therapeutic for inflammatory bowel disease would is in excess of $1 billion per annum in the US. ..
  44. BRAIN OXIDATIVE STRESS--A SIGN OF AGING OR EMINENT DEATH
    Mostafa Badr; Fiscal Year: 2000
    ..Consequently, early diagnosis of this condition may present the opportunity to intervene to slow or halt neuronal degeneration and aging. ..
  45. Antioxidant Functions of Lipoic Acid
    James May; Fiscal Year: 2004
    ..Despite the widespread use of lipoic acid, these studies are necessary to establish the biological basis and rationale for the clinical use of the agent. ..
  46. OXIDATION RISK FACTORS AND IMT PROGESSION IN FH
    Paul Hopkins; Fiscal Year: 2004
    ..Our major hypothesis is that IMT progression will be strongly related to the balance of pro-oxidant and antioxidant factors. The newly added imaging techniques will allow us to compare and contrast results using these endpoints as well. ..
  47. Diabetes, Exercise and Postprandial Oxidative Stress
    Lauretta Quinn; Fiscal Year: 2005
    ..insulin, C-peptides and triglycerides) following 3 meals; (2) postprandial oxidative stress (total MDA, F2 Isoprostanes, total hydroperoxides, vitamin A, E and carotenoids) and LDL susceptibility to oxidation (lag time, maximal ..
  48. IMMUNOASSAY FOR A NON-ENZYMATIC ARACHIDONATE DERIVATIVE
    KRISHNAMOORTHY SANKARAN; Fiscal Year: 1993
    ....
  49. SOCIAL AND PHYSICAL ENVIRONMENTS AND HEALTH DISPARITIES
    Amy Schulz; Fiscal Year: 2004
    ....
  50. Mechanisms of CYP1A regulation and lung injury by oxygen
    Weiwu Jiang; Fiscal Year: 2007
    ..g., F2 isoprostanes and isofurans), whose levels are elevated in hyperoxic lungs. We proposed 2 Specific Aims. 1...
  51. Non-traditional Cardiovascular Risk Factors in DM type 2
    Peter Reaven; Fiscal Year: 2004
    ..Long- term (future) aims will include evaluating the prospective relationship of these novel cardiovascular risk factors to the progression of atherosclerosis and the development of macrovascular disease in this same population. ..
  52. HUMAN ISOPROSTANE METABOLITES--DETECTING OXIDANT STRESS
    DIANE SASAKI; Fiscal Year: 1999
    ..Recent studies indicate that a large percentage of free F2 isoprostanes detected in urine is produced locally by the kidney, whereas F2 isoprostanes derived from systemic oxidant ..
  53. TGF-Beta, Glucose and Nephropathy in African Americans
    Bonita Falkner; Fiscal Year: 2007
    ..abstract_text> ..
  54. ATHEROSCLEROSIS IN RA
    CHARLES STEIN; Fiscal Year: 2004
    ....
  55. Vitamin D/Calcium and Oxidative Stress and Inflammation Biomarkers
    ROBERD MANER BOSTICK; Fiscal Year: 2010
    ....
  56. CYTOCHROME P450 AND LUNG IN HUMAN PRETERM INFANTS
    ROBERT COTTON; Fiscal Year: 2000
    ....
  57. CORONARY REACTIVITY AND OXIDATIVE STRESS
    Joseph Vita; Fiscal Year: 1999
    ..To examine the contribution of superoxide production to abnormal coronary activity, vasomotor responses will be examined following treatment with specific inhibitors of superoxide action. ..
  58. OXIDATIVE DAMAGE AND THE RISK OF CORONARY HEART DISEASE
    Mark Woodward; Fiscal Year: 2004
    ..Each case will be matched to two controls who had no CHD event, giving a total sample size of 879. ..
  59. Oxidative Stress and Genetics of Prehypertension
    Shawna Nesbitt; Fiscal Year: 2004
    ..will: 1) in the placebo group, determine if individuals with high normal BP and high oxidative stress levels (F2 isoprostanes and glutathione ratio) are at high risk for progression to hypertension; 2) in the ARB group, determine if ..
  60. Reactive gamma-Ketoaldehydes in Dementia
    L Roberts; Fiscal Year: 2008
    ..We will also explore a novel pharmacologic intervention, the ability of pyridoxamine to selectively prevent IsoK/NK adduction and mitigate the memory deficit in the mouse model. ..
  61. Lipid Oxidation Products in Alzheimer's Disease
    Thomas Montine; Fiscal Year: 2007
    ..abstract_text> ..
  62. CATECHOL THIOETHERS IN PARKINSON'S DISEASE
    Thomas Montine; Fiscal Year: 2004
    ....
  63. LIPID PEROXIDATION AND APOE IN ALZHEIMERS DISEASE
    Thomas Montine; Fiscal Year: 2003
    ..This new information will aid in laying the foundation for designing rational therapeutic approaches to ameliorate brain oxidative damage in Alzheimer's disease. ..