conjugated linoleic acids

Summary

Summary: A collective term for a group of around nine geometric and positional isomers of LINOLEIC ACID in which the trans/cis double bonds are conjugated, where double bonds alternate with single bonds.

Top Publications

  1. ncbi Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cells
    Mairead Coakley
    Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland
    Nutr Cancer 56:95-102. 2006
  2. ncbi Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress
    Paolo Bergamo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche CNR ISA, Via Roma 52, 83100, Avellino, Italy
    Free Radic Biol Med 43:71-9. 2007
  3. ncbi Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
    Christine E Loscher
    Department of Clinical Medicine, Institute of Molecular Medicine, Dublin, Ireland
    J Immunol 175:4990-8. 2005
  4. ncbi Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFA
    Sebastiano Banni
    Universita degli Studi di Cagliari, Dipartimento di Biologia Sperimentale, Cittadella Universitaria, Cagliari, Italy
    Lipids 39:1143-6. 2004
  5. ncbi Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner
    Seong Ho Lee
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 27:972-81. 2006
  6. ncbi Influence of organic diet on the amount of conjugated linoleic acids in breast milk of lactating women in the Netherlands
    Lukas Rist
    Research Department, Paracelsus Hospital Richterswil, Bergstrasse 16, CH 8805 Richterswil, Switzerland
    Br J Nutr 97:735-43. 2007
  7. pmc Bioactive dietary long-chain fatty acids: emerging mechanisms of action
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University, College Station, TX, USA
    Br J Nutr 100:1152-7. 2008
  8. pmc Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol
    Arion Kennedy
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    J Lipid Res 50:225-32. 2009
  9. ncbi Metabolism and short-term metabolic effects of conjugated linoleic acids in rat hepatocytes
    Paola Priore
    Laboratory of Biochemistry, Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, 73100 Lecce, Italy
    Biochim Biophys Acta 1771:1299-307. 2007
  10. ncbi Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cells
    Sawitree Wongtangtintharn
    United Graduate School of Agricultural Sciences, Kagoshima University, 1 21 24, Korimoto, Kagoshima 890 0065, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:137-43. 2004

Research Grants

  1. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
  2. Mechanisms of NaCl Absorption in the Human Colon
    Pradeep K Dudeja; Fiscal Year: 2013
  3. Physiological Significance of Conjugated Double Bonds in Membrane Lipids
    Papasani Subbaiah; Fiscal Year: 2009
  4. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
  5. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani Subbaiah; Fiscal Year: 2008
  6. TNF Modulation of Mammary Proliferation
    MARGOT IP; Fiscal Year: 2007
  7. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
  8. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2008
  9. Molecular biomarkers of selenium chemoprevention
    Clement Ip; Fiscal Year: 2006
  10. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2008

Detail Information

Publications271 found, 100 shown here

  1. ncbi Intestinal bifidobacteria that produce trans-9, trans-11 conjugated linoleic acid: a fatty acid with antiproliferative activity against human colon SW480 and HT-29 cancer cells
    Mairead Coakley
    Teagasc, Moorepark Food Research Centre, Fermoy, County Cork, Ireland
    Nutr Cancer 56:95-102. 2006
    ..It is tempting to suggest that the ability of Bifidobacterium to produce such bioactive metabolites may be associated with the beneficial effects of bifidobacteria present in the human gastrointestinal tract...
  2. ncbi Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress
    Paolo Bergamo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche CNR ISA, Via Roma 52, 83100, Avellino, Italy
    Free Radic Biol Med 43:71-9. 2007
    ..In conclusion our data indicate that the activation of detoxifying enzymes may be one of the mechanisms whereby dietary CLA down-regulates oxidative stress in MRL/lpr mice...
  3. ncbi Conjugated linoleic acid suppresses NF-kappa B activation and IL-12 production in dendritic cells through ERK-mediated IL-10 induction
    Christine E Loscher
    Department of Clinical Medicine, Institute of Molecular Medicine, Dublin, Ireland
    J Immunol 175:4990-8. 2005
    ....
  4. ncbi Conjugated linoleic acids (CLA) as precursors of a distinct family of PUFA
    Sebastiano Banni
    Universita degli Studi di Cagliari, Dipartimento di Biologia Sperimentale, Cittadella Universitaria, Cagliari, Italy
    Lipids 39:1143-6. 2004
    ..e., n-3, n-6 and n-9) PUFA families. It is likely that perturbation of PUFA metabolism by CLA will have an impact on eicosanoid formation and metabolism, closely linked to the biological activities attributed to CLA...
  5. ncbi Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner
    Seong Ho Lee
    Department of Pathobiology, College of Veterinary Medicine, University of Tennessee, Knoxville, TN 37996, USA
    Carcinogenesis 27:972-81. 2006
    b>Conjugated linoleic acids (CLAs), naturally occurring fatty acids in ruminant food products, have anti-tumorigenic and pro-apoptotic properties in animal as well as in vitro models of cancer...
  6. ncbi Influence of organic diet on the amount of conjugated linoleic acids in breast milk of lactating women in the Netherlands
    Lukas Rist
    Research Department, Paracelsus Hospital Richterswil, Bergstrasse 16, CH 8805 Richterswil, Switzerland
    Br J Nutr 97:735-43. 2007
    ..Hence, the levels of CLA and TVA in human milk can be modulated if breastfeeding mothers replace conventional dairy and/or meat products by organic ones. A potential contribution of CLA and TVA to health improvement is briefly discussed...
  7. pmc Bioactive dietary long-chain fatty acids: emerging mechanisms of action
    Robert S Chapkin
    Faculty of Nutrition, Texas A and M University, College Station, TX, USA
    Br J Nutr 100:1152-7. 2008
    ....
  8. pmc Conjugated linoleic acid-mediated inflammation and insulin resistance in human adipocytes are attenuated by resveratrol
    Arion Kennedy
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    J Lipid Res 50:225-32. 2009
    ..Collectively, these data demonstrate for the first time that RSV prevents 10,12 CLA-mediated insulin resistance and delipidation in human adipocytes by attenuating inflammation and cellular stress and increasing PPARgamma activity...
  9. ncbi Metabolism and short-term metabolic effects of conjugated linoleic acids in rat hepatocytes
    Paola Priore
    Laboratory of Biochemistry, Department of Biological and Environmental Sciences and Technologies, University of Salento, via prov le Lecce Monteroni, 73100 Lecce, Italy
    Biochim Biophys Acta 1771:1299-307. 2007
    Metabolic fate and short-term effects of a 1:1 mixture of cis-9,trans-11 and trans-10,cis-12-conjugated linoleic acids (CLA), compared to linoleic acid (LA), on lipid metabolism was investigated in rat liver...
  10. ncbi Effect of branched-chain fatty acids on fatty acid biosynthesis of human breast cancer cells
    Sawitree Wongtangtintharn
    United Graduate School of Agricultural Sciences, Kagoshima University, 1 21 24, Korimoto, Kagoshima 890 0065, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:137-43. 2004
    ..The present study thus suggests that BCFA synthetically lowers the fatty acid biosynthesis by reducing the precursors, in addition to its direct inhibitory effect on fatty acid synthetase...
  11. ncbi Conjugated linoleic acids modulate UVR-induced IL-8 and PGE2 in human skin cells: potential of CLA isomers in nutritional photoprotection
    Amy Storey
    Department of Medicine, University of Liverpool, Liverpool, UK
    Carcinogenesis 28:1329-33. 2007
    b>Conjugated linoleic acids (CLA), derivatives of linoleic acid found in food products, inhibit chemically induced skin cancers in mice. However, their potential photoprotective properties remain unexplored...
  12. ncbi Effect of conjugated linoleic acids on the activity and mRNA expression of 5- and 15-lipoxygenases in human macrophages
    Ewa Stachowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, Szczecin, Poland al Powstancow Wlkp 72, 70 111 Szczecin, Poland
    J Agric Food Chem 55:5335-42. 2007
    ..Studies on conjugated linoleic acids (CLAs) as fatty acids with a potential anti-atherosclerotic function have recently been initiated...
  13. ncbi Board-invited review: Recent advances in biohydrogenation of unsaturated fatty acids within the rumen microbial ecosystem
    T C Jenkins
    Department of Animal and Veterinary Sciences, Clemson University, Clemson, SC 29634, USA
    J Anim Sci 86:397-412. 2008
    ....
  14. ncbi Trans10, cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilization in rat hepatoma cells
    Masao Yamasaki
    Division of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University, Miyazaki 889 2192, Japan
    Biochim Biophys Acta 1735:176-84. 2005
    ..10t, 12c-CLA directly degraded the isolated lysosomes from the rat liver. Our observations indicate that 10t, 12c-CLA induces mitochondria-related apoptosis accompanied by lysosomal destabilization in rat hepatoma cells...
  15. ncbi Conjugated linoleic acids have no effect on TNF alpha-induced adhesion molecule expression, U937 monocyte adhesion, and chemokine release in human aortic endothelial cells
    Sabine Schleser
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, Emil Abderhaldenstrasse 26, D 06108 Halle Saale, Germany
    Atherosclerosis 186:337-44. 2006
    ..b>Conjugated linoleic acids (CLA), which are natural ligands of PPARs, were demonstrated to have anti-inflammatory and anti-..
  16. ncbi Effect of different types of fibre supplemented with sunflower oil on ruminal fermentation and production of conjugated linoleic acids in vitro
    Yanling Li
    State Key Laboratory of Animal Nutrition, College of Animal Sciences and Technology, China Agricultural University, Beijing
    Arch Anim Nutr 60:402-11. 2006
    ..of different types of fibre supplemented with sunflower oil on ruminal fermentation and formation of conjugated linoleic acids (CLA) by mixed ruminal microorganisms...
  17. ncbi Metabolism of conjugated linoleic acids and 18 : 1 fatty acids by ruminal bacteria: products and mechanisms
    Nest McKain
    Rowett Institute of Nutrition and Health, University of Aberdeen, Bucksburn, Aberdeen AB21 9SB, UK
    Microbiology 156:579-88. 2010
    ....
  18. ncbi Biohydrogenation, duodenal flow, and intestinal digestibility of trans fatty acids and conjugated linoleic acids in response to dietary forage:concentrate ratio and linseed oil in dairy cows
    J J Loor
    Unite de Recherches sur les Herbivores, INRA Theix, 63122 St Genes Champanelle, France
    J Dairy Sci 87:2472-85. 2004
    ..Duodenal flow of total conjugated linoleic acids (CLA) increased by 1.40 (LCO) to 3.01 (HCO) g/d with linseed oil...
  19. ncbi Rumen ciliate protozoa contain high concentrations of conjugated linoleic acids and vaccenic acid, yet do not hydrogenate linoleic acid or desaturate stearic acid
    Estelle Devillard
    Rowett Research Institute, Greenburn Road, Bucksburn, Aberdeen AB21 9SB, UK
    Br J Nutr 96:697-704. 2006
    b>Conjugated linoleic acids (CLA) have been shown to improve human health. They are derived from the microbial conversion of dietary linoleic acid (cis-9,cis-12-18 : 2 (LA)) in the rumen...
  20. ncbi Lipid class distribution of fatty acids including conjugated linoleic acids in healthy and cancerous parts of human kidneys
    Kristina Hoffmann
    lnstitute of Biochemistry and Food Chemistry, University of Hamburg, Germany
    Lipids 40:1057-62. 2005
    ....
  21. ncbi Inhibition of fatty acid transport and proliferative activity in tissue-isolated human squamous cell cancer xenografts perfused in situ with melatonin or eicosapentaenoic or conjugated linoleic acids
    Robert T Dauchy
    Bassett Research Institute, The Mary Imogene Bassett Hospital, Cooperstown, NY, USA
    Comp Med 57:377-82. 2007
    Melatonin and eicosapentaenoic and 10t,12c-conjugated linoleic acids suppress the growth-stimulating effects of linoleic acid (LA) and its metabolism to the mitogenic agent 13-(S)-hydroxyoctadecadienoic acid (13-(S)-HODE) in established ..
  22. ncbi Use of principal component analysis to investigate the origin of heptadecenoic and conjugated linoleic acids in milk
    V Fievez
    Department of Animal Production, Ghent University, Proefhoevestraat 10, 9090 Melle, Belgium
    J Dairy Sci 86:4047-53. 2003
    ..Within the range of diets and cows studied here, we showed changes in cis-9,trans-11 conjugated linoleic acid to be mainly dependent on vaccenic acid supply and to a lesser extent on variation in desaturase activity...
  23. ncbi Trans-10,cis-12 CLA increases liver and decreases adipose tissue lipids in mice: possible roles of specific lipid metabolism genes
    J M Warren
    Western Human Nutrition Research Center, ARS, USDA, and Department of Nutrition, University of California, Davis, California 95616, USA
    Lipids 38:497-504. 2003
    ..These initial results suggest that changes associated with energy homeostasis and insulin action may mediate the effects of t10,c12-CLA on lipid metabolism...
  24. ncbi Trans10, cis12-conjugated linoleic acid prevents triacylglycerol accumulation in adipocytes by acting as a PPARgamma modulator
    Linda Granlund
    Institute for Nutrition Research, University of Oslo, N 0316 Oslo, Norway
    J Lipid Res 44:1441-52. 2003
    A group of polyunsaturated fatty acids called conjugated linoleic acids (CLAs) are found in ruminant products, where the most common isomers are cis9, trans11 (c 9,t11) and trans10, cis12 (t10,c12) CLA...
  25. ncbi The combination of dietary conjugated linoleic acid and treadmill exercise lowers gain in body fat mass and enhances lean body mass in high fat-fed male Balb/C mice
    Arunabh Bhattacharya
    Department of Medicine, Division of Clinical Immunology, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Nutr 135:1124-30. 2005
    ..b>Conjugated linoleic acids (CLA) were shown to decrease fat and increase lean mass in several animal studies...
  26. ncbi Conjugated linoleic acid--mediated apoptosis in Jurkat T cells involves the production of reactive oxygen species
    Paolo Bergamo
    National Research Council, Institute of Food Sciences CNR ISA, Avellino, Italy
    Cell Physiol Biochem 14:57-64. 2004
    ..These results suggested that CLA can trigger apoptosis through an oxidative stress mediated by the PKC/NADPH oxidase pathway. The proposed mechanism provides a new insight into the anticancer activity of CLA...
  27. ncbi Conjugated linoleic acids can change phagocytosis of human monocytes/macrophages by reduction in Cox-2 expression
    Ewa Stachowska
    Department of Biochemistry, Pomeranian Medical University, Szczecin, Poland
    Lipids 42:707-16. 2007
    ..The inhibition of PGE2 synthesis (by CLA treatment) enhanced the phagocytosis process in macrophages...
  28. ncbi Hepatic lipid and carbohydrate metabolism in rats fed a commercial mixture of conjugated linoleic acids (Clarinol G-80)
    Anna M Giudetti
    Laboratory of Biochemistry, Dept of Biological and Environmental Sciences and Technologies, University of Lecce, Italy
    Eur J Nutr 44:33-9. 2005
    b>Conjugated linoleic acids (CLAs) exert numerous effects in animal models as well as in humans. Among other things, CLAs decrease plasma lipid levels and bring about hepatic steatosis...
  29. ncbi Effect of linseed oil supplementation on concentrations of (n-3) polyunsaturated fatty acids in liver phospholipids of rats fed diets containing either an oil rich in conjugated linoleic acids, sunflower oil or high-oleic acid sunflower oil
    K Eder
    Institute of Nutritional Sciences, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    J Anim Physiol Anim Nutr (Berl) 89:45-54. 2005
    ..The results show that feeding the CLA oil reduced the formation of arachidonic acid and eicosanoids but enhanced the formation of long chain (n-3) PUFA and their incorporation into tissue lipids when compared with feeding SFO or HO-SFO...
  30. ncbi Prostaglandin E2 (PGE2) and thromboxane A2 (TXA2) synthesis is regulated by conjugated linoleic acids (CLA) in human macrophages
    E Stachowska
    Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, ul Zolnierska 48, Szczecin, Poland
    J Physiol Pharmacol 60:77-85. 2009
    ..COX-1 inhibition was resulting from competition of CLA and linoleic acid with arachidonic acid...
  31. ncbi Activation of PPAR gamma and delta by conjugated linoleic acid mediates protection from experimental inflammatory bowel disease
    Josep Bassaganya-Riera
    Laboratory of Nutritional Immunology and Molecular Nutrition, Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Gastroenterology 127:777-91. 2004
    ..We used a loss-of-function approach to investigate whether CLA ameliorated colitis through a peroxisome proliferator-activated receptor gamma (PPAR gamma)-dependent mechanism...
  32. pmc Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes
    J Mark Brown
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, NC 27402 6170, USA
    J Lipid Res 44:1287-300. 2003
    ....
  33. ncbi Impaired lipid accumulation by trans10, cis12 CLA during adipocyte differentiation is dependent on timing and length of treatment
    Linda Granlund
    Institute of Basic Medical Sciences, Department of Nutrition, University of Oslo, N 0316 Oslo, Norway
    Biochim Biophys Acta 1687:11-22. 2005
    b>Conjugated linoleic acids (CLAs) are a group of polyunsaturated fatty acids found in ruminant products, where the predominant isomers are cis9, trans11 (c9,t11) and trans10, cis12 (t10,c12) CLA...
  34. ncbi Potentiation of the anti-tumour effect of docetaxel by conjugated linoleic acids (CLAs) in breast cancer cells in vitro
    Alemu Fite
    Section of Surgical Oncology, Department of Surgery, University of Aberdeen, Medical School, Foresterhill, Aberdeen, Aberdeen, Scotland, UK
    Prostaglandins Leukot Essent Fatty Acids 77:87-96. 2007
    ..b>Conjugated linoleic acids (CLAs) also have anti-tumorigenic activity that elicits similar changes in oncogene expression to DOCT ..
  35. ncbi Methods for analysis of conjugated linoleic acids and trans-18:1 isomers in dairy fats by using a combination of gas chromatography, silver-ion thin-layer chromatography/gas chromatography, and silver-ion liquid chromatography
    Cristina Cruz-Hernandez
    Agriculture and Agri Food Canada, Food Research Program, 93 Stone Rd West, Guelph, Ontario, Canada
    J AOAC Int 87:545-62. 2004
    b>Conjugated linoleic acids (CLA) are octadecadienoic acids (18:2) that have a conjugated double-bond system...
  36. ncbi Conjugated linoleic acid preserves gastrocnemius muscle mass in mice bearing the colon-26 adenocarcinoma
    Erin Graves
    National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA
    Res Nurs Health 28:48-55. 2005
    ..CLA preserved gastrocnemius muscle mass and reduced TNF receptors in muscle of tumor-bearing mice. These data suggest that CLA may preserve muscle mass by reducing the catabolic effects of TNF on skeletal muscle...
  37. pmc Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes
    Arion Kennedy
    Department of Nutrition, University of North Carolina, Greensboro, NC 27402 6170, USA
    J Nutr 138:455-61. 2008
    ..Collectively, we demonstrate for the first time, to our knowledge, that 10,12 CLA antagonizes ligand-dependent PPARgamma activity, possibly via PPARgamma phosphorylation by ERK...
  38. ncbi Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men
    Ulf Riserus
    Clinical Nutrition Research Unit, Department of Public Health and Caring Sciences Geriatrics, Uppsala University, Box 609, 75125 Uppsala, Sweden
    Am J Clin Nutr 80:279-83. 2004
    ..Because c9,t11 CLA is the predominant CLA isomer in foods and is included in dietary weight-loss products, it is important to conduct randomized controlled studies that use c9,t11 CLA preparations...
  39. pmc Prolonged treatment of genetically obese mice with conjugated linoleic acid improves glucose tolerance and lowers plasma insulin concentration: possible involvement of PPAR activation
    Ed Wargent
    Clore Laboratory for Life Sciences, University of Buckingham, Buckingham, MK18 1EG, UK
    Lipids Health Dis 4:3. 2005
    ..We have conducted three experiments with CLA in obese mice over three weeks, and one over eleven weeks. We have also investigated the effects of CLA isomers in PPARgamma and PPARalpha reporter gene assays...
  40. ncbi Conjugated linoleic acid alters global gene expression in human intestinal-like Caco-2 cells in an isomer-specific manner
    Eileen F Murphy
    Department of Food and Nutritional Sciences, University College, Cork, Ireland
    J Nutr 137:2359-65. 2007
    ..These may help our mechanistic understanding of the role of CLA in promoting gut function and health...
  41. ncbi The effect of conjugated linoleic acid on the viability and metabolism of human osteoblast-like cells
    S Cusack
    Department of Food and Nutritional Sciences, University College, Western Road, Cork, Ireland
    Prostaglandins Leukot Essent Fatty Acids 72:29-39. 2005
    ..These results suggest a lack of cytotoxic effect of CLA on human osteoblast-like cells and tentatively suggest a possible beneficial effect on bone formation in humans...
  42. ncbi Effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on immune cell function in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, The University of Reading, Reading, United Kingdom
    Am J Clin Nutr 80:1626-33. 2004
    ..However, little information on the effects of CLA on immune function is available, especially in humans. Furthermore, the effects of individual isomers of CLA have not been adequately investigated...
  43. ncbi Insulin secretion after dietary supplementation with conjugated linoleic acids and n-3 polyunsaturated fatty acids in normal and insulin-resistant mice
    Maria Sörhede Winzell
    Dept of Clinical Sciences, Medicine, Lund University, BMC, B11, SE 221 84 Lund, Sweden
    Am J Physiol Endocrinol Metab 290:E347-54. 2006
    b>Conjugated linoleic acids (CLAs) and n-3 polyunsaturated fatty acids (PUFAs) improve insulin sensitivity in insulin-resistant rodents...
  44. ncbi Effect of CLA supplementation on immune function in young healthy volunteers
    H J Song
    Rowett Research Institute, Aberdeen, UK
    Eur J Clin Nutr 59:508-17. 2005
    ..This study investigated the effect of dietary CLA supplementation (3g/day; 50:50 mix of the two major isomers) on the immune system and plasma lipids and glucose of healthy human (male and female) volunteers...
  45. ncbi Opposing effects of cis-9,trans-11 and trans-10,cis-12 conjugated linoleic acid on blood lipids in healthy humans
    Sabine Tricon
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, Whiteknights, Reading RG6 6AP, United Kingdom
    Am J Clin Nutr 80:614-20. 2004
    ..However, the effects of CLA on human health and, in particular, the effects of individual CLA isomers are unclear...
  46. ncbi Conjugated linoleic acids, atherosclerosis, and hepatic very-low-density lipoprotein metabolism
    Roger S McLeod
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Canada
    Am J Clin Nutr 79:1169S-1174S. 2004
    b>Conjugated linoleic acids (CLAs) are isomeric forms of the 18:2 fatty acid that contain conjugated sites of unsaturation. Although CLAs are minor components of the diet, they have many reported biological activities...
  47. ncbi Contribution of conjugated linoleic acid to the suppression of inflammatory responses through the regulation of the NF-kappaB pathway
    Wen Ling Cheng
    Departments of Nutrition and Life Sciences, Chung Shan Medical University, Number 110, Section 1, Chien Kuo North Road, Taichung 40203, Taiwan, Republic of China
    J Agric Food Chem 52:71-8. 2004
    ..7 macrophages and this inhibitory activity of CLA, at least in part, occurs through CLA modulating the NF-kappaB activation and therefore negatively regulating expression of inflammatory mediators...
  48. ncbi Conjugated linoleic acids: why the discrepancy between animal and human studies?
    Mélanie Plourde
    Research Center on Aging and Departments of Medicine, and Physiology and Biophysics, Universite de Sherbrooke, Sherbrooke, Quebec, Canada
    Nutr Rev 66:415-21. 2008
    b>Conjugated linoleic acids (CLA) are positional and geometric isomers of linoleic acid. In animals, CLA consumption reduces body fat but results in humans are less conclusive...
  49. ncbi Conjugated linoleic acids reduce body fat in healthy postmenopausal women
    Marianne Raff
    Department of Human Nutrition, Faculty of Life, University of Copenhagen, Frederiksberg 1958, Denmark
    J Nutr 139:1347-52. 2009
    Isomers of conjugated linoleic acids (CLA) reduce fat mass (FM) and increase insulin sensitivity in some, but not all, murine studies. In humans, this effect is still debatable...
  50. ncbi Conjugated linoleic acid versus high-oleic acid sunflower oil: effects on energy metabolism, glucose tolerance, blood lipids, appetite and body composition in regularly exercising individuals
    Estelle V Lambert
    UCT MRC Research Unit for Exercise Science and Sports Medicine, Department of Human Biology, Faculty of Health Sciences, University of Cape Town, PO Box 115 Newlands, 7725, South Africa
    Br J Nutr 97:1001-11. 2007
    ....
  51. ncbi Conjugated linoleic acid isomers' roles in the regulation of PPAR-gamma and NF-kappaB DNA binding and subsequent expression of antioxidant enzymes in human umbilical vein endothelial cells
    Yukiko K Nakamura
    Department of Nutrition and Environmental Sciences, University of Nevada, Reno, USA
    Nutrition 25:800-11. 2009
    ....
  52. ncbi Gender differences in the cardiac response to dietary conjugated linoleic acid isomers
    Paramjit S Tappia
    Institute of Cardiovascular Sciences, St Boniface Hospital Research Centre, University of Manitoba, 351 Tache Avenue, Winnipeg, MB R2H 2A6, Canada
    Can J Physiol Pharmacol 84:257-64. 2006
    ..These results indicate that CLA isomers exert differential effects on heart function and suggest the need for a complete evaluation of the benefits, interactions, and potential side effects of each isomer...
  53. ncbi Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese
    Jean Michel Gaullier
    Link Medical Research AS, Kjeller, Norway
    Br J Nutr 97:550-60. 2007
    ..Adverse events did not differ between the groups. It is concluded that supplementation with CLA in healthy, overweight and obese adults decreases BFM in specific regions and is well tolerated...
  54. ncbi Concentrations of conjugated linoleic acids in neonatal blood in relationship to those in maternal blood
    Andre Muller
    Institut fur Biochemie und Lebensmittelchemie, Universitat Hamburg, Grindelallee 117, D 20146 Hamburg, Germany
    Prostaglandins Leukot Essent Fatty Acids 76:213-9. 2007
    In this study, the proportions of conjugated linoleic acids (CLA) in total lipids of plasma, lipoproteins and erythrocytes from maternal blood and from venous cord blood of 20 pregnant women consuming conventional western diets after ..
  55. ncbi Conjugated linoleic acid increases skeletal muscle ceramide content and decreases insulin sensitivity in overweight, non-diabetic humans
    A Brianne Thrush
    Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, N1G 2W1, Canada
    Appl Physiol Nutr Metab 32:372-82. 2007
    ..In conclusion, mixed-isomer CLA supplementation in overweight non-diabetic humans results in the accumulation of CLA and ceramide in skeletal muscle, and decreases insulin sensitivity...
  56. pmc Mining the microbiota of the neonatal gastrointestinal tract for conjugated linoleic acid-producing bifidobacteria
    E Rosberg-Cody
    Biotechnology, Dairy Products Research Centre, Teagasc, Moorepark, Fermoy, County Cork, Ireland
    Appl Environ Microbiol 70:4635-41. 2004
    ..The ability of some Bifidobacterium strains to produce CLA could be another human health-promoting property linked to members of the genus, given that this metabolite has demonstrated anticarcinogenic activity in vitro and in vivo...
  57. pmc Conjugated linoleic acid promotes human adipocyte insulin resistance through NFkappaB-dependent cytokine production
    Soonkyu Chung
    Department of Nutrition, University of North Carolina at Greensboro, Greensboro, North Carolina 27402 6170, USA
    J Biol Chem 280:38445-56. 2005
    ....
  58. ncbi Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid inhibits G1-S progression in HT-29 human colon cancer cells
    Han Jin Cho
    Department of Food Science and Nutrition, Hallym University, Chuncheon, 200 702, Korea
    J Nutr 136:893-8. 2006
    ..The induction of p21(CIP1/WAF1) may be one of the mechanisms by which t10c12 inhibits cell cycle progression in HT-29 cells...
  59. ncbi Production of (10E,12Z)-conjugated linoleic acid in yeast and tobacco seeds
    Ellen Hornung
    Georg August University Gottingen, Albrecht von Haller Institute for Plant Sciences, Department of Plant Biochemistry, Justus von Liebig Weg 11, D 37077 Gottingen, Germany
    Biochim Biophys Acta 1738:105-14. 2005
    ..CLA was only detected in seeds in coPAI-transgenic plants. The amount of CLA detected in esterified fatty acids was up to 0.3%, in free fatty acids up to 15%...
  60. ncbi Conjugated linoleic acid deteriorates insulin resistance in obese/diabetic mice in association with decreased production of adiponectin and leptin
    Atsuko Ohashi
    Department of Clinical Pharmacology and Toxicology Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Tohbetsu, Hokkaido 061 029 3, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:416-21. 2004
    Dietary supplementation of conjugated linoleic acids (CLA) is known to have some beneficial effects such as anti-carcinogenic and anti-obesity effects in several animal species, while it also induces insulin resistance and fatty liver, ..
  61. ncbi Dietary conjugated linoleic acid reduces lipid peroxidation by increasing oxidative stability in rats
    Hye Kyeong Kim
    Food Function Research Division, Korea Food Research Institute, Seongnam 463 746, Korea
    J Nutr Sci Vitaminol (Tokyo) 51:8-15. 2005
    ..5% CLA group than in other groups. These results suggest that dietary CLA has antiatherosclerotic and antioxidant activity by increasing oxidative stability in plasma and hepatic membrane in the vitamin E-deficient rats...
  62. ncbi Conjugated linoleic acids promote human fat cell apoptosis
    P Fischer-Posovszky
    Department of Pediatrics and Adolescent Medicine, University of Ulm, 89075 Ulm, Germany
    Horm Metab Res 39:186-91. 2007
    b>Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid. Some isomers have been shown to reduce fat mass in animal and cell culture models...
  63. ncbi cis-9,trans-11-conjugated linoleic acid down-regulates phorbol ester-induced NF-kappaB activation and subsequent COX-2 expression in hairless mouse skin by targeting IkappaB kinase and PI3K-Akt
    Dal Mi Hwang
    National Research Laboratory of Molecular Carcinogenesis and Chemoprevention, College of Pharmacy, Seoul 151 742, South Korea
    Carcinogenesis 28:363-71. 2007
    ..Taken together, 9Z,11E-CLA inhibits NF-kappaB driven-COX-2 expression by blocking the IKK and PI3K-Akt signaling in TPA-treated hairless mouse skin in vivo, which may account for its previously reported anti-tumor promoting effects...
  64. ncbi Conjugated linoleic acid protects against age-associated bone loss in C57BL/6 female mice
    Md Mizanur Rahman
    Department of Medicine, Division of Clinical Immunology and Rheumatology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229 3900, USA
    J Nutr Biochem 18:467-74. 2007
    ..In conclusion, these findings suggest that CLA may prevent the loss of bone and muscle mass by modulating markers of inflammation and osteoclastogenic factors...
  65. ncbi Conjugated linoleic acid supplementation reduces peripheral blood mononuclear cell interleukin-2 production in healthy middle-aged males
    Anne Mullen
    Nutrigenomics Research Group, Department of Clinical Medicine and Institute of Molecular Medicine, St James s Hospital, Dublin 8, Ireland
    J Nutr Biochem 18:658-66. 2007
    ..This study showed that CLA supplementation reduced PBMC IL-2 secretion from Con A-stimulated PBMC but lacked effect on other markers of the human inflammatory response...
  66. ncbi Conjugated linoleic acids exert similar actions on prostanoid release from aortic and coronary artery smooth muscle cells
    Robert Ringseis
    Institut fur Ernahrungswissenschaften, Martin Luther Universitat Halle Wittenberg, D 06108 Halle Saale, Germany
    Int J Vitam Nutr Res 76:281-9. 2006
    b>Conjugated linoleic acids (CLAs) are biologically active lipid compounds exerting anti-atherogenic actions in vivo without exact knowledge about the underlying mechanisms...
  67. ncbi Daily intake of conjugated linoleic acid-enriched yoghurts: effects on energy metabolism and adipose tissue gene expression in healthy subjects
    Julie Anne Nazare
    Centre de Recherche en Nutrition Humaine de Lyon, Universite Claude Bernard Lyon 1, France
    Br J Nutr 97:273-80. 2007
    ..Moreover, changes in mRNA PPAR gamma and HSL in adipose tissue were recorded...
  68. ncbi Inhibition of colon cancer cell proliferation by the dietary compound conjugated linoleic acid is mediated by the CDK inhibitor p21CIP1/WAF1
    Do Y Lim
    Division of Life Sciences, Hallym University, Chunchon, Korea
    J Cell Physiol 205:107-13. 2005
    ..These studies indicate that physiological concentrations of CLA inhibit growth of colon cancer cells with either wild-type or mutant p53, and may have therapeutic benefits in vivo...
  69. ncbi Safety of dietary conjugated linoleic acid (CLA) in a 12-weeks trial in healthy overweight Japanese male volunteers
    Toshio Iwata
    Research Laboratory, The Nisshin OilliO Group, Ltd, Tokyo, Japan
    J Oleo Sci 56:517-25. 2007
    ..These results indicate that CLA at a dose of 3.4 g/day is a safe dietary level in healthy Japanese populations in terms of the parameters examined...
  70. ncbi The effect of conjugated linoleic acid on calcium absorption and bone metabolism and composition in adult ovariectomised rats
    O Kelly
    Department of Food and Nutritional Sciences, University College, Western Road, Cork, Ireland
    Prostaglandins Leukot Essent Fatty Acids 71:295-301. 2004
    ..001) lowered by CLA supplementation with 5 and 10, but not 2.5 g/kg diet in OVX rats. In conclusion, CLA supplementation appeared to reduce the rate of bone resorption in adult OVX rats...
  71. ncbi The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain
    A C Watras
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Int J Obes (Lond) 31:481-7. 2007
    ..Although research in humans has shown inconsistent results, most studies have been of insufficient duration or have utilized body composition methods that are less accurate than the currently accepted criterion...
  72. ncbi Association between dietary conjugated linoleic acid and bone mineral density in postmenopausal women
    Rhonda A Brownbill
    University of Connecticut, Division of Health and Human Development, School of Allied Health, 358 Mansfield Rd, Storrs, CT 06269, USA
    J Am Coll Nutr 24:177-81. 2005
    ..To determine if dietary conjugated linoleic acid (CLA) is associated with bone mineral density (BMD) of different skeletal sites in postmenopausal women...
  73. ncbi Conjugated linoleic acid reduces hepatic steatosis, improves liver function, and favorably modifies lipid metabolism in obese insulin-resistant rats
    Amy Noto
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada R3T 2N2
    Lipids 41:179-88. 2006
    ..In summary, these results illustrate a strong relationship between the state of insulin resistance and liver lipid metabolism and suggest that CLA acts to favorably modify lipid metabolism in fa/fa Zucker rats...
  74. ncbi Efficacy of conjugated linoleic acid for reducing fat mass: a meta-analysis in humans
    Leah D Whigham
    Department of Obstetrics and Gynecology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792 6188, USA
    Am J Clin Nutr 85:1203-11. 2007
    ..Conjugated linoleic acid (CLA) has been shown to be an effective supplement for reducing fat mass in animals, whereas results in humans have been inconsistent...
  75. ncbi Effect of feeding systems on omega-3 fatty acids, conjugated linoleic acid and trans fatty acids in Australian beef cuts: potential impact on human health
    Eric N Ponnampalam
    Department of Food Science, RMIT University, Melbourne, Victoria 3001, Australia
    Asia Pac J Clin Nutr 15:21-9. 2006
    ..Data from the present study show that grain feeding decreases functional lipid components (long chain n-3 FA and CLA) in Australian beef regardless of meat cuts, while increasing total trans 18:1 and saturated FA levels...
  76. ncbi Cis-9, trans- 11 and trans-10, cis-12 conjugated linoleic acid (CLA) do not affect the plasma lipoprotein profile in moderately overweight subjects with LDL phenotype B
    Elke Naumann
    Department of Human Biology, Maastricht University, Maastricht, The Netherlands
    Atherosclerosis 188:167-74. 2006
    ..Results of a pilot study suggested that cis-9, trans-11 conjugated linoleic acid (CLA) improved LDL phenotype in moderately overweight subjects with LDL phenotype B...
  77. ncbi Diets rich in conjugated linoleic acid and vaccenic acid have no effect on blood pressure and isobaric arterial elasticity in healthy young men
    Marianne Raff
    Department of Human Nutrition, The Royal Veterinary and Agricultural University, Frederiksberg, Denmark
    J Nutr 136:992-7. 2006
    ..BP) and isobaric arterial elasticity (AE), as a measure of arterial health, of a commercial mixture of conjugated linoleic acids (CLA) and of milk fat produced through livestock feeding to have a high content of vaccenic acid (VA)...
  78. ncbi Effects of the individual isomers cis-9,trans-11 vs. trans-10,cis-12 of conjugated linoleic acid (CLA) on inflammation parameters in moderately overweight subjects with LDL-phenotype B
    Julian D Ramakers
    Department of Human Biology, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, The Netherlands
    Lipids 40:909-18. 2005
    ..Inflammatory signatures in fasting, nonstimulated plasma as determined by an antibody array may indicate enhanced immune function by both CLA isomers...
  79. ncbi Rumenic acid significantly reduces plasma levels of LDL and small dense LDL cholesterol in hamsters fed a cholesterol- and lipid-enriched semi-purified diet
    Martial LeDoux
    Laboratoire d Etudes et de Recherches sur la Qualité des Aliments et les Procédés agroalimentaires, Agence Francaise de Securite Sanitaire des Aliments, Maisons Alfort, France
    Lipids 42:135-41. 2007
    b>Conjugated linoleic acids (CLAs) consist of a series of positional and geometrical isomers of linoleic acid. CLA have been reported to beneficially affect cardiovascular risk factors in animal models...
  80. ncbi Calcium and conjugated linoleic acid reduces pregnancy-induced hypertension and decreases intracellular calcium in lymphocytes
    Julian A Herrera
    Department of Family Medicine, School of Medicine, Universidad del Valle, Cali, Colombia
    Am J Hypertens 19:381-7. 2006
    ....
  81. ncbi Nutritional supplementation with trans-10, cis-12-conjugated linoleic acid induces inflammation of white adipose tissue
    Hélène Poirier
    Physiologie de la Nutrition, ENSBANA, Unité Mixte de Recherche 5170 CESG Centre National de la Recherche Scientifique Institut National de la Recherche Agronomique Université de Bourgogne, Dijon, 21000 France
    Diabetes 55:1634-41. 2006
    b>Conjugated linoleic acids (CLAs) are conjugated dienoic isomers of linoleic acid...
  82. ncbi Conjugated linoleic acid intake in humans: a systematic review focusing on its effect on body composition, glucose, and lipid metabolism
    J Salas-Salvado
    Departament de Bioquimica i Biotecnologia, Facultat de Medicina i Ciencies de la Salut de Reus, Spain
    Crit Rev Food Sci Nutr 46:479-88. 2006
    ..Therefore, long-term randomized clinical trials, controlled with placebo, need to be made in large samples of patients to evaluate the efficacy and safety of CLA isomers before its indiscriminate use in human beings can be recommended...
  83. ncbi Conjugated linoleic acid enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-Fas(lpr) mice
    Paolo Bergamo
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    J Lipid Res 47:2382-91. 2006
    ..In conclusion, enhanced GSH content and GCLC expression in CLA-treated mice suggest a novel biochemical mechanism underlying its immunomodulatory activity and the beneficial effects on murine SLE signs...
  84. ncbi Trans-10,cis-12, not cis-9,trans-11, conjugated linoleic acid decreases ErbB3 expression in HT-29 human colon cancer cells
    Han Jin Cho
    Department of Food Science and Nutrition, Hallym University, 1 Okchon Dong, Chuncheon 200 702, Korea
    World J Gastroenterol 11:5142-50. 2005
    ..To examine whether trans-10,cis-12 CLA (t10c12) or cis-9,trans-11 CLA (c9t11) inhibits heregulin (HRG)-beta-stimulated cell growth and HRG-beta-ErbB3 signaling in HT-29 cells...
  85. ncbi Lack of effect of dietary conjugated linoleic acids naturally incorporated into butter on the lipid profile and body composition of overweight and obese men
    Sophie Desroches
    Institute on Nutraceuticals and Functional Foods, Laval University, Quebec, Canada
    Am J Clin Nutr 82:309-19. 2005
    ..Of the few studies that investigated the effects of CLA supplementation in humans, all used commercially formulated oral supplements made from a mixture of CLA isomers...
  86. ncbi Conjugated linoleic acid and hepatic lipogenesis in mouse: role of the mitochondrial citrate carrier
    Alessandra Ferramosca
    Department of Sciences and Biological and Environmental Technologies, University of Lecce, 73100 Lecce, Italy
    J Lipid Res 47:1994-2003. 2006
    ..These data indicate that the CIC may play a role in the onset of hepatic steatosis in CLA-fed mice by supplying the carbon source for de novo fatty acid synthesis...
  87. ncbi Distribution of polyunsaturated fatty acids including conjugated linoleic acids in total and subcellular fractions from healthy and cancerous parts of human kidneys
    Kristina Hoffmann
    Institute of Biochemistry and Food Chemistry, University of Hamburg, 20146 Hamburg, Germany
    Lipids 40:309-15. 2005
    ..Further understanding of the cause and/or consequence of the difference in FA metabolism may lead to a better understanding of RCC...
  88. ncbi Conjugated linoleic acid attenuates cyclooxygenase-2 transcriptional activity via an anti-AP-1 mechanism in MCF-7 breast cancer cells
    Stephanie C Degner
    Department of Nutritional Sciences, Arizona Cancer Center, The University of Arizona, Tucson, AZ 85721, USA
    J Nutr 136:421-7. 2006
    ..Collectively, these results suggest that CLA represses AP-1-mediated activation of COX-2 transcription...
  89. ncbi Conjugated linoleic acids
    Bill Campbell
    Exercise and Performance Nutrition Laboratory, Department of Physical Education and Exercise Science, University of South Florida, FL, USA
    Curr Sports Med Rep 7:237-41. 2008
    ..Additionally, recent investigations into the safety of CLA supplementation also are reviewed...
  90. ncbi Conjugated linoleic acids and CLA-containing phospholipids inhibit NO formation in aortic endothelial cells
    Kimberly J Jenko
    Department of Biochemistry and Molecular Biology, The George Washington University School of Medicine, 2300 Eye Street, N W, Washington, DC 20037, USA
    Lipids 43:335-42. 2008
    ....
  91. ncbi Conjugated linoleic acid isomers and cancer
    Nirvair S Kelley
    Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis, CA 95616 8643, USA
    J Nutr 137:2599-607. 2007
    ..Additional studies with purified isomers are needed to establish the health benefit and risk ratios of each isomer in humans...
  92. ncbi Dose response of milk fat to intravenous administration of the trans-10, cis-12 isomer of conjugated linoleic acid
    S Viswanadha
    Department of Animal and Veterinary Science, University of Idaho, Moscow 83844, USA
    J Dairy Sci 86:3229-36. 2003
    ..Intravenous infusion of the trans-10, cis-12 isomer of CLA depressed milk fat in a linear manner over the range of infusion studied and, therefore, is an alternative to abomasal infusion...
  93. ncbi Conjugated linoleic acid and atherosclerosis: studies in animal models
    Patricia L Mitchell
    Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, NS, Canada
    Biochem Cell Biol 86:293-301. 2008
    b>Conjugated linoleic acids (CLA) are isomeric forms of linoleic acid (LA) containing two conjugated sites of unsaturation...
  94. ncbi Conjugated linoleic acid enhances plasma adiponectin level and alleviates hyperinsulinemia and hypertension in Zucker diabetic fatty (fa/fa) rats
    Koji Nagao
    Laboratory of Nutrition Biochemistry, Department of Applied Biological Sciences, Saga University, Saga 840 8502, Japan
    Biochem Biophys Res Commun 310:562-6. 2003
    ..We speculate that the increase alleviates hyperinsulinemia and prevents the onset of hypertension in CLA-fed ZDF rats...
  95. ncbi Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: effects on the expression of G1-restriction points in breast and colon cancer cells
    Michael Q Kemp
    Nutritional Sciences Interdisciplinary Program, Laboratory of Mammary Gland Biology, Department of Nutritional Sciences, The University of Arizona, Tucson, AZ 85718, USA
    J Nutr 133:3670-7. 2003
    ....
  96. ncbi Conjugated linoleic acid supplementation modified the body composition and serum leptin levels in weaning rats
    Adriana Prais Botelho
    Laboratory of Lipids, Department of Food and Nutrition, College of Food Engineering, State University of Campinas, Brasil
    Arch Latinoam Nutr 58:156-63. 2008
    ..05). Supplementation with conjugated linoleic acid in the concentration of 2% of mean daily feed consumption was able to change body composition of rats after 42 days of experimentation...
  97. ncbi Antioxidant effect of conjugated linoleic acid and vitamin A during non enzymatic lipid peroxidation of rat liver microsomes and mitochondria
    Alejandro Palacios
    Catedra de Bioquimica, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina
    Mol Cell Biochem 250:107-13. 2003
    ..The simultaneous analysis of peroxidizability index, chemiluminescence and fatty acid composition demonstrated that CLA is more effective than vitamin A protecting microsomes or mitochondria from peroxidative damage...
  98. ncbi Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans
    Jean Michel Gaullier
    Scandinavian Clinical Research AS, Kjeller, Norway
    Am J Clin Nutr 79:1118-25. 2004
    ..Short-term trials showed that conjugated linoleic acid (CLA) may reduce body fat mass (BFM) and increase lean body mass (LBM), but the long-term effect of CLA was not examined...
  99. ncbi Dietary conjugated linoleic acid and insulin sensitivity and resistance in rodent models
    Carla G Taylor
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Canada
    Am J Clin Nutr 79:1164S-1168S. 2004
    ..The different responses of normal compared with insulin-resistant obese rodents suggest that interactions of CLA isomers with the cellular components that contribute to development of metabolic syndrome require further investigation...
  100. ncbi Analysis of conjugated linoleic acid and trans 18:1 isomers in synthetic and animal products
    John K G Kramer
    Food Research Program, Agriculture and Agri Food Canada, Guelph, Ontario, Canada
    Am J Clin Nutr 79:1137S-1145S. 2004
    ..These improved techniques are used to evaluate the CLA profile in pork products from pigs fed different commercial CLA mixtures...
  101. ncbi Conjugated linoleic acid reduces parathyroid hormone in health and in polycystic kidney disease in rats
    Hope Weiler
    Department of Human Nutritional Sciences, University of Manitoba, Winnipeg, Manitoba, Canada
    Am J Clin Nutr 79:1186S-1189S. 2004
    ..Feeding conjugated linoleic acid (CLA) is reported to reduce prostaglandin E(2) synthesis, which is required for parathyroid hormone (PTH) release...

Research Grants23

  1. Role of Membrane Modifications in the Bioactivities of Conjugated Linoleic Acids
    Papasani V Subbaiah; Fiscal Year: 2013
    ..provided by applicant): The major goal of this proposal is to investigate the mechanism of action of conjugated linoleic acids (CLA), the naturally occurring isomers of linoleic acid (LA), which have several unique physicochemical ..
  2. Mechanisms of NaCl Absorption in the Human Colon
    Pradeep K Dudeja; Fiscal Year: 2013
    ..evidence for the regulation of DRA expression by both HNFs and their activators dexamenthasone (DEX) and conjugated linoleic acids (CLAs), as well as miRNAs...
  3. Physiological Significance of Conjugated Double Bonds in Membrane Lipids
    Papasani Subbaiah; Fiscal Year: 2009
    ..are generally detrimental to human health, a new class of naturally occurring trans fatty acids, called conjugated linoleic acids (CLA), which are found in dairy products and meat, have been shown to have several health benefits...
  4. Mechanisms of Immune Modulation by Abscisic Acid
    Josep Bassaganya Riera; Fiscal Year: 2010
    ..The mechanistic understanding of the immune modulatory properties of botanicals such as ABA will aid in the development of more efficacious CAM approaches for modulating immune function and ameliorating infectious diseases. ..
  5. ROLE OF SPHINGOMYELIN IN LIPOPROTEIN METABOLISM
    Papasani Subbaiah; Fiscal Year: 2008
    ..These studies will provide novel insights into the physiological role of this important phospholipid, and could possibly open up novel therapeutic targets against inflammation and atherosclerosis. ..
  6. TNF Modulation of Mammary Proliferation
    MARGOT IP; Fiscal Year: 2007
    ..Thus, as part of this aim, the efficacy of anti-TNF therapy vs local TNF therapy against mammary tumors will be compared. ..
  7. LCAT AND PATHOPHYSIOLOGY OF PHOSPHOLIPID SPECIES
    Papasani Subbaiah; Fiscal Year: 2002
    ..These studies should provide novel insights into the physiological importance of LCAT beyond its role in cholesterol esterification. ..
  8. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2008
    ..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
  9. Molecular biomarkers of selenium chemoprevention
    Clement Ip; Fiscal Year: 2006
    ..The goal is to broaden our understanding of the significance of clonal suppression of early transformed cells in selenium protection of cancer. ..
  10. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2008
    ..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..
  11. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    ..The objective is to corroborate the significance of clonal suppression of preneoplastic lesions in selenium protection of cancer. ..
  12. ALCOHOL INDUCED IMMUNOMODULATION--RETROVIRAL CARDIOPATH
    RONALD WATSON; Fiscal Year: 2003
    ..Such studies could provide the basis for their application to reduce heart disease in alcohol-abusing, HIV-infected patients. ..
  13. NONINVASIVE MEASUREMENT OF ENERGY EXPENDITURE IN HUMANS
    Dale Schoeller; Fiscal Year: 2007
    ..These studies will provide important guidelines for the prescription of exercise for the prevention and treatment of obesity. ..
  14. Phytoestrogens and breast cancer risk
    Susan McCann; Fiscal Year: 2006
    ..These investigations, combining retrospective and experimental designs, as well as genetic analyses, will help to elucidate the role of dietary phytoestrogen intake in the etiology of a hormone- sensitive cancer. ..
  15. MAMMARY CANCER PREVENTION BY CONJUGATED LINOLEIC ACID
    Clement Ip; Fiscal Year: 2007
    ..abstract_text> ..
  16. Selenium molecular signaling in human prostate cancer
    Clement Ip; Fiscal Year: 2007
    ..Aim 4 is to study the transcriptional control of GADD153 by selenium. The proposed research is thus designed to examine systemically the impact of GADD153 induction as a result of selenium treatment. ..
  17. IMMUNOMODULATION OF RETROVIRAL CARDIOPATHOLOGY
    RONALD WATSON; Fiscal Year: 2001
    ..The treatments that found to prevent cytokine dysregulation and cardiotoxicitiy in retrovirally infected mice will then be applicable to reducing heart disease in HIV infected patients (End of Abstract) ..
  18. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..abstract_text> ..
  19. SUPPRESSION OF T CELL ACTIVATION BY DIETARY FATTY ACIDS
    ROBERT CHAPKIN; Fiscal Year: 2003
    ..g., rheumatoid arthritis), without compromising host defenses. ..
  20. ISOTOPE RATIO MASS SPECTROMETER
    Dale Schoeller; Fiscal Year: 2006
    ..In addition, this new instrument will provide new capacity in the form of the solids combustion inlet. This expands our potential users group in the area of development of dietary biomarkers. [unreadable] [unreadable]..