eicosanoids

Summary

Summary: A class of compounds named after and generally derived from C20 fatty acids (EICOSANOIC ACIDS) that includes PROSTAGLANDINS; LEUKOTRIENES; THROMBOXANES, and HYDROXYEICOSATETRAENOIC ACIDS. They have hormone-like effects mediated by specialized receptors (RECEPTORS, EICOSANOID).

Top Publications

  1. pmc Eicosanoids and cancer
    Dingzhi Wang
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Nat Rev Cancer 10:181-93. 2010
  2. pmc Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
    S A Kliewer
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 94:4318-23. 1997
  3. ncbi Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
    Hedi Harizi
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5540, Immunomodulation par les Médiateurs de l Inflammation, University of Bordeaux, 33076, France
    Trends Mol Med 14:461-9. 2008
  4. pmc Regulation of inflammation in cancer by eicosanoids
    Emily R Greene
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Prostaglandins Other Lipid Mediat 96:27-36. 2011
  5. ncbi The role of prostaglandins and other eicosanoids in the gastrointestinal tract
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 128:1445-61. 2005
  6. pmc Eicosanoids, β-cell function, and diabetes
    Pengcheng Luo
    Department of Nephrology, Renmin Hospital of Wuhan University, China
    Prostaglandins Other Lipid Mediat 95:1-10. 2011
  7. ncbi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
  8. ncbi Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids
    F Catella-Lawson
    University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 289:735-41. 1999
  9. pmc Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype
    Paul C Norris
    Department of Chemistry, University of California, San Diego, La Jolla, CA 92093 0601, USA
    J Leukoc Biol 90:563-74. 2011
  10. pmc Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
    Cancer Metastasis Rev 29:723-35. 2010

Detail Information

Publications276 found, 100 shown here

  1. pmc Eicosanoids and cancer
    Dingzhi Wang
    Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030 4009, USA
    Nat Rev Cancer 10:181-93. 2010
    b>Eicosanoids, including prostaglandins and leukotrienes, are biologically active lipids that have been implicated in various pathological processes, such as inflammation and cancer...
  2. pmc Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors alpha and gamma
    S A Kliewer
    Department of Molecular Endocrinology, Glaxo Wellcome Research and Development, Five Moore Drive, Research Triangle Park, NC 27709, USA
    Proc Natl Acad Sci U S A 94:4318-23. 1997
    ..of lipid homeostasis and are activated by a structurally diverse group of compounds including fatty acids, eicosanoids, and hypolipidemic drugs such as fibrates and thiazolidinediones...
  3. ncbi Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
    Hedi Harizi
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5540, Immunomodulation par les Médiateurs de l Inflammation, University of Bordeaux, 33076, France
    Trends Mol Med 14:461-9. 2008
    Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that regulate a wide variety of physiological responses and pathological processes...
  4. pmc Regulation of inflammation in cancer by eicosanoids
    Emily R Greene
    Vascular Biology Program, Children s Hospital Boston, Harvard Medical School, Boston, MA, USA
    Prostaglandins Other Lipid Mediat 96:27-36. 2011
    ..These lipid mediators are collectively referred to as eicosanoids and are generated by distinct enzymatic systems initiated by cyclooxygenases (COX 1 and 2), lipoxygenases (5-..
  5. ncbi The role of prostaglandins and other eicosanoids in the gastrointestinal tract
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 128:1445-61. 2005
    ..Prostaglandins and other eicosanoids derived from COX-1 and COX-2 are involved in a variety of physiologic and pathologic processes in the ..
  6. pmc Eicosanoids, β-cell function, and diabetes
    Pengcheng Luo
    Department of Nephrology, Renmin Hospital of Wuhan University, China
    Prostaglandins Other Lipid Mediat 95:1-10. 2011
    ..acid (AA) is metabolized by cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP) enzymes into eicosanoids, which are involved in diverse diseases, including type 1 and type 2 diabetes...
  7. ncbi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
    ..the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs eicosapentaenoic acid (EPA) and docosahexaenoic ..
  8. ncbi Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids
    F Catella-Lawson
    University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, USA
    J Pharmacol Exp Ther 289:735-41. 1999
    ..Our data suggest that acute sodium retention by nonsteroidal anti-inflammatory drugs in healthy elderly subjects is mediated by the inhibition of Cox-2, whereas depression of GFR is due to inhibition of Cox-1...
  9. pmc Specificity of eicosanoid production depends on the TLR-4-stimulated macrophage phenotype
    Paul C Norris
    Department of Chemistry, University of California, San Diego, La Jolla, CA 92093 0601, USA
    J Leukoc Biol 90:563-74. 2011
    ..Using a lipidomic approach, we comprehensively analyzed the eicosanoids made by murine RPMs, TGEMs, BMDM, and the macrophage-like cell line RAW after stimulation with the TLR-4-..
  10. pmc Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
    Cancer Metastasis Rev 29:723-35. 2010
    ..In this review, the emerging role in cancer of cytochrome P450 metabolites, notably 20-HETE and EETs, are discussed...
  11. ncbi Secretory phospholipases A2 in inflammatory and allergic diseases: not just enzymes
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 116:1000-6. 2005
    ..sPLA(2)s release arachidonic acid, thereby providing the substrate for the biosynthesis of proinflammatory eicosanoids. However, there are other mechanisms by which sPLA(2)s might participate in the synthesis of lipid mediators...
  12. ncbi Role of eicosanoids in prostate cancer progression
    D Nie
    Department of Radiation Oncology, Wayne State University School of Medicine and Karmanos Cancer Institute, Detroit, MI 48202, USA
    Cancer Metastasis Rev 20:195-206. 2001
    ..through cyclooxygenase, lipoxygenase, or P450 epoxygenase pathways leads to the formation of various bioactive eicosanoids. In this review, we discuss alterations in expression pattern of eicosanoid-generating enzymes found during ..
  13. pmc Evidence for role of epoxyeicosatrienoic acids in mediating ischemic preconditioning and postconditioning in dog
    Garrett J Gross
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Am J Physiol Heart Circ Physiol 297:H47-52. 2009
    ..These results suggest a unique role for endogenous EETs in both IPC and POC...
  14. ncbi Eicosanoids and the endogenous control of acute inflammatory resolution
    Derek W Gilroy
    Centre for Clinical Pharmacology and Therapeutics, Division of Medicine, 5 University Street, University College London, London WC1E 6JJ, United Kingdom
    Int J Biochem Cell Biol 42:524-8. 2010
    ..In this setting, the biochemical synthesis of key pro-resolution eicosanoids as well as their mode of action in self-limiting inflammation will be discussed.
  15. pmc Serotonergic 5-HT(2B) receptor controls tissue-nonspecific alkaline phosphatase activity in osteoblasts via eicosanoids and phosphatidylinositol-specific phospholipase C
    Anne Baudry
    Cellules Souches, Signalisation et Prions, INSERM U747, Universite Paris Descartes, Paris, France
    J Biol Chem 285:26066-73. 2010
    ..In agreement with the above findings, primary calvarial osteoblasts from 5-HT(2B)R-null mice exhibit defects in TNAP activity...
  16. ncbi Sensory and signaling mechanisms of bradykinin, eicosanoids, platelet-activating factor, and nitric oxide in peripheral nociceptors
    Gábor Petho
    Pharmacodynamics Unit, Department of Pharmacology and Pharmacotherapy, Faculty of Medicine, University of Pecs, Pecs, Hungary
    Physiol Rev 92:1699-775. 2012
    ..Identified molecular elements of these signaling pathways may serve as validated targets for development of novel types of analgesic drugs...
  17. pmc Importance of group X-secreted phospholipase A2 in allergen-induced airway inflammation and remodeling in a mouse asthma model
    William R Henderson
    Center for Allergy and Inflammation, Department of Medicine, University of Washington, Seattle, WA 98109, USA
    J Exp Med 204:865-77. 2007
    Arachidonic acid metabolites, the eicosanoids, are key mediators of allergen-induced airway inflammation and remodeling in asthma...
  18. ncbi Comprehensive lipidomics analysis of bioactive lipids in complex regulatory networks
    Mojgan Masoodi
    Elsie Widdowson Laboratory, Medical Research Council, Cambridge, United Kingdom
    Anal Chem 82:8176-85. 2010
    ..A multistep procedure was implemented to extract eicosanoids and other bioactive lipids from the biological matrix, chromatographically separate them using fast reversed-..
  19. pmc Production of eicosanoids and other oxylipins by pathogenic eukaryotic microbes
    Mairi C Noverr
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0642, USA
    Clin Microbiol Rev 16:517-33. 2003
    Oxylipins are oxygenated metabolites of fatty acids. Eicosanoids are a subset of oxylipins and include the prostaglandins and leukotrienes, which are potent regulators of host immune responses...
  20. pmc Necrotizing enterocolitis: a multifactorial disease with no cure
    Kareena L Schnabl
    Alberta Institute for Human Nutrition, 4 10 Ag For Centre, University of Alberta, Edmonton, Alberta T6G 2P5, Canada
    World J Gastroenterol 14:2142-61. 2008
    ....
  21. ncbi Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
    J H Capdevila
    Departments of Medicine, Vanderbilt University Medical School, Nashville, TN 372323, USA
    J Lipid Res 41:163-81. 2000
    ..The characterization of the potent biological activities associated with several of the cytochrome P450-derived eicosanoids suggested new and important functional roles for these enzymes in cellular, organ, and body physiology, ..
  22. pmc Epoxyeicosanoids as mediators of neurogenic vasodilation in cerebral vessels
    Jeffrey J Iliff
    Dept of Anesthesiology and Peri Operative Medicine, Oregon Health and Science Univ, 3181 SW Sam Jackson Pk Rd, UHS 2, Portland, OR 97239 3098, USA
    Am J Physiol Heart Circ Physiol 296:H1352-63. 2009
    ..The findings have important implications to such clinical conditions as migraine, vasospasm after subarachnoid hemorrhage, and stroke...
  23. ncbi Emerging roles for eicosanoids in renal diseases
    Niels O S Camara
    Department of Immunology, Institute of Biomedical Sciences, University of Sao Paulo, Sao Paulo, SP, Brazil
    Curr Opin Nephrol Hypertens 18:21-7. 2009
    b>Eicosanoids are products of arachidonic acid metabolism which have important roles in renal homeostasis and disease...
  24. ncbi A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry
    Yoshihiro Kita
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 0033, Japan
    Anal Biochem 342:134-43. 2005
    b>Eicosanoids and platelet-activating factor (PAF) are phospholipid-derived lipid mediators produced by various tissues and cells through a cascade pathway...
  25. pmc Transgenic mice rich in endogenous omega-3 fatty acids are protected from colitis
    Christian A Hudert
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 103:11276-81. 2006
    ..traditionally attributed to their ability to inhibit the formation of n-6 PUFA-derived proinflammatory eicosanoids. Newly discovered resolvins and protectins are potent antiinflammatory lipid mediators derived directly from n-..
  26. ncbi Mast cells and eicosanoid mediators: a system of reciprocal paracrine and autocrine regulation
    Joshua A Boyce
    Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Immunol Rev 217:168-85. 2007
    When activated by specific antigen, complement, or other transmembrane stimuli, mast cells (MCs) generate three eicosanoids: prostaglandin (PG)D(2), leukotriene (LT)B(4), and LTC(4), the parent molecule of the cysteinyl leukotrienes (..
  27. ncbi Expression and characterization of human cytochrome P450 4F11: Putative role in the metabolism of therapeutic drugs and eicosanoids
    Auinash Kalsotra
    Department of Biochemistry and Molecular Biology, University of Texas Medical School, Houston 77030, USA
    Toxicol Appl Pharmacol 199:295-304. 2004
    ..we have expressed CYP4F11 in Saccharomyces cerevisiae and examined its catalytic properties towards endogenous eicosanoids as well as some clinically relevant drugs...
  28. ncbi A novel role for P450 eicosanoids in the neurogenic control of cerebral blood flow in the rat
    Jeffrey J Iliff
    Department of Anesthesiology and Peri Operative Medicine, Oregon Health and Science University, 3181 S W Sam Jackson Park Road, UHS 2, Portland, OR 97239 3098, USA
    Exp Physiol 92:653-8. 2007
    The P450 eicosanoids epoxyeicosatrienoic acids (EETs) are endogenous lipid mediators produced in the brain by P450 epoxygenases and metabolized through multiple pathways, including soluble epoxide hydrolase (sEH)...
  29. ncbi Polyunsaturated fatty acids (PUFA) and eicosanoids in human health and pathologies
    H Tapiero
    UNIVERSITE DE PARIS, Faculté de Pharmacie CNRS UMR 8612, Chatenay Malabry, France
    Biomed Pharmacother 56:215-22. 2002
    ....
  30. ncbi Measurement of eicosanoids in cancer tissues
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Methods Enzymol 433:27-50. 2007
    b>Eicosanoids derived from arachidonic acid through cyclooxygenase (COX), lipoxygenase (LOX), and P450 pathways include prostanoids, hydroxyeicosatetraenoic acids (HETEs), leukotrienes (LTs), and epoxyeicosatrienoic acids (EETs)...
  31. ncbi Renal vascular cytochrome P450-derived eicosanoids in androgen-induced hypertension
    Harpreet Singh
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Pharmacol Rep 60:29-37. 2008
    ..The Cytochrome P450 (CYP)-derived eicosanoids, 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs) have been implicated in the ..
  32. ncbi The role of eicosanoids in the brain
    Daniella Tassoni
    Deakin University, School of Exercise and Nutrition Sciences, 221 Burwood Highway, Burwood, Victoria 3125, Australia
    Asia Pac J Clin Nutr 17:220-8. 2008
    ..AA is also metabolised to lipoxins via the 5-lipoxygenase pathway. The eicosanoids formed play important roles in neural function including sleep induction (PGD2), long term potentiation, ..
  33. ncbi Effects of cannabinoids on LPS-stimulated inflammatory mediator release from macrophages: involvement of eicosanoids
    Y H Chang
    Department of Pharmacology, College of Medicine, National Taiwan University, Taipei, Taiwan
    J Cell Biochem 81:715-23. 2001
    ..The endogenous cannabinoid, 2-AG, also serves as a substrate for COX-catalyzing PGE(2) production, which in turn modulates the action of CB2...
  34. ncbi Eicosanoids mediate hemolymph oxidative and antioxidative response in larvae of Galleria mellonella L
    Ender Büyükgüzel
    Department of Biology, Faculty of Arts and Science, Karaelmas University, 67100, Zonguldak, Turkey
    Comp Biochem Physiol A Mol Integr Physiol 156:176-83. 2010
    ..We posed the hypothesis that eicosanoids also mediate antioxidant enzymatic defense reactions to pro-oxidant challenge...
  35. pmc Evaluation of cytochrome P450-derived eicosanoids in humans with stable atherosclerotic cardiovascular disease
    Katherine N Theken
    Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
    Atherosclerosis 222:530-6. 2012
    ..Therefore, the primary objective was to identify clinical factors that influence CYP epoxygenase, soluble epoxide hydrolase (sEH), and CYP ω-hydroxylase metabolism in patients with established CAD...
  36. pmc Cytochrome P450-derived eicosanoids and vascular dysfunction in coronary artery disease patients
    Robert N Schuck
    Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, NC, USA
    Atherosclerosis 227:442-8. 2013
    ....
  37. ncbi Role of mitochondria in programmed cell death mediated by arachidonic acid-derived eicosanoids
    Huiyong Yin
    Laboratory of Lipid Metabolism in Human Nutrition and Related Diseases, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China
    Mitochondrion 13:209-24. 2013
    Arachidonic acid-derived eicosanoids from cyclooxygenases, lipoxygenases, and cytochrome P450 are important lipid mediators involved in numerous homeostatic and pathophysiological processes...
  38. pmc Cytochrome P450 eicosanoids and cerebral vascular function
    John D Imig
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Expert Rev Mol Med 13:e7. 2011
    The eicosanoids 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic acids (EETs), which are generated from the metabolism of arachidonic acid by cytochrome P450 (CYP) enzymes, possess a wide array of biological actions, ..
  39. ncbi Eicosanoids: generation and detection in mammalian cells
    VALERIE B O'DONNELL
    Department of Medical Biochemistry and Immunology, Cardiff University, Heath Park, Cardiff, UK
    Methods Mol Biol 462:5-23. 2009
    b>Eicosanoids are 20-carbon lipids generated by the oxidation of arachidonic acid that are involved in physiological signaling in virtually all organ systems...
  40. pmc Epoxyeicosatrienoic acids are endogenous regulators of vasoactive neuropeptide release from trigeminal ganglion neurons
    Jeffrey J Iliff
    Department of Anesthesiology and Perioperative Medicine, Oregon Health and Science University, Portland, Oregon 97239 3098, USA
    J Neurochem 115:1530-42. 2010
    Epoxyeicosatrienoic acids (EETs) are bioactive eicosanoids produced from arachidonic acid by cytochrome P450 epoxygenases...
  41. ncbi Clotting factors and eicosanoids protect against nematode infections
    Pavel Hyrsl
    Department of Molecular Biology and Functional Genomics, Stockholm University, Stockholm, Sweden
    J Innate Immun 3:65-70. 2011
    ..We also provide biochemical and genetic evidence for an involvement of eicosanoids in the same infection model...
  42. ncbi Valproic acid down-regulates the conversion of arachidonic acid to eicosanoids via cyclooxygenase-1 and -2 in rat brain
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Neurochem 85:690-6. 2003
    ..release and recycling of AA within brain phospholipids, and the conversion of AA via COX-2 to PGE2 and related eicosanoids. If targeting this part of the 'AA cascade' accounts for their therapeutic action, non-steroidal anti-..
  43. pmc Esterified eicosanoids are acutely generated by 5-lipoxygenase in primary human neutrophils and in human and murine infection
    Stephen R Clark
    Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, United Kingdom
    Blood 117:2033-43. 2011
    ..Thus, new molecular species of oxidized PL formed by human neutrophils during bacterial infection are identified and characterized...
  44. ncbi Fcgamma RI-triggered generation of arachidonic acid and eicosanoids requires iPLA2 but not cPLA2 in human monocytic cells
    Hwee Kee Tay
    Department of Physiology, Faculty of Medicine, National University of Singapore, Singapore 117597
    J Biol Chem 279:22505-13. 2004
    ....
  45. ncbi Stability and analysis of eicosanoids and docosanoids in tissue culture media
    Krishna Rao Maddipati
    Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48202, USA
    Prostaglandins Other Lipid Mediat 94:59-72. 2011
    ..Other than the few clinically used eicosanoids such as prostaglandin F(2)α, prostacyclin, and prostaglandin E(2), little is known about the stability of a ..
  46. pmc Rhinosinusitis in COPD: symptoms, mucosal changes, nasal lavage cells and eicosanoids
    Violetta M Piotrowska
    Department of Pediatric Otolaryngology, Medical University of Lodz, Poland
    Int J Chron Obstruct Pulmon Dis 5:107-17. 2010
    ..Nasal lavages were collected for cytological examination and eicosanoids (cysteinyl leukotrienes, leukotriene B4, 8-isoprostane)...
  47. ncbi Induction of tumor necrosis factor-alpha by UVB: a role for reactive oxygen intermediates and eicosanoids
    Annemie Pupe
    Department of Dermatology, Katholieke Universiteit Leuven, Leuven, Belgium
    Photochem Photobiol 78:68-74. 2003
    ..COX products and more importantly LOX products, which themselves are products of an oxidative metabolism, are the main ROI implicated in this induction of TNF-alpha expression by UVB probably via activation of NF-kappaB...
  48. pmc Effects of cyclo-oxygenase inhibition on exhaled eicosanoids in patients with COPD
    P Montuschi
    Department of Pharmacology, Faculty of Medicine, School of Medicine, Catholic University of the Sacred Heart, Largo F Vito 1, 00168 Rome, Italy
    Thorax 60:827-33. 2005
    ..A study was undertaken to investigate the short term effects of cyclo-oxygenase (COX) inhibition on exhaled LTB4 and PGE2 concentrations in patients with COPD and to identify the COX isoform responsible for exhaled PGE2 production...
  49. ncbi Oxylipins as developmental and host-fungal communication signals
    Dimitrios I Tsitsigiannis
    The Sainsbury Laboratory, John Innes Centre, Norwich Research Park, Colney Lane, Norwich, NR4 7UH, UK
    Trends Microbiol 15:109-18. 2007
    ..these results suggest that host and microbial oxylipins might interfere with the metabolism, perception or signalling processes of each other...
  50. ncbi Eicosanoids mediate prophenoloxidase release from oenocytoids in the beet armyworm Spodoptera exigua
    Sony Shrestha
    Department of Bioresource Science, Andong National University, Andong 760 749, Republic of Korea
    Insect Biochem Mol Biol 38:99-112. 2008
    ..It has been suggested that eicosanoids are implicated in PPO activation in the beet armyworm, Spodoptera exigua...
  51. ncbi Groups IV, V, and X phospholipases A2s in human neutrophils: role in eicosanoid production and gram-negative bacterial phospholipid hydrolysis
    Norbert Degousee
    Division of Vascular Surgery, Max Bell Research Center, Toronto General Hospital, University Health Network, Toronto M5G 2C4, Canada
    J Biol Chem 277:5061-73. 2002
    ....
  52. ncbi Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats
    Qing Jiang
    Division of Biochemistry and Molecular Biology, University of California, Berkeley and Children s Hospital Oakland Research Institute, Oakland, California 94609 1673, USA
    FASEB J 17:816-22. 2003
    ..These findings provide strong evidence that gammaT shows anti-inflammatory activities in vivo that may be important for human disease prevention and therapy...
  53. pmc Direct activation of capsaicin receptors by products of lipoxygenases: endogenous capsaicin-like substances
    S W Hwang
    Sensory Research Group, National Creative Research Initiatives, College of Pharmacy, Seoul National University, San 56 1, Shinlim, Kwanak gu, Seoul 151 742, Korea
    Proc Natl Acad Sci U S A 97:6155-60. 2000
    ..The eicosanoids also activated the cloned capsaicin receptor (VR1) expressed in HEK cells...
  54. ncbi Biosynthesis of eicosanoids and transcellular metabolism of leukotrienes in murine bone marrow cells
    Miguel A Gijón
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Aurora, CO 80045 6511, USA
    J Lipid Res 48:716-25. 2007
    ..Mouse bone marrow PMNs were found to synthesize eicosanoids upon stimulation with A23187, fMLP, or zymosan...
  55. pmc Phosphatidylethanolamine-esterified eicosanoids in the mouse: tissue localization and inflammation-dependent formation in Th-2 disease
    Alwena H Morgan
    Department of Medical Biochemistry and Immunology, Tenovus Building, Heath Park, School of Medicine, Cardiff University, Cardiff CF14 4XN, United Kingdom
    J Biol Chem 284:21185-91. 2009
    ..The studies suggest a new paradigm for lipids generated by 12/15-LOX in inflammation involving formation of esterified eicosanoids.
  56. pmc Cyclooxygenase-2-specific inhibitor improves functional outcomes, provides neuroprotection, and reduces inflammation in a rat model of traumatic brain injury
    Jonas J Gopez
    Department of Neurosurgery, Temple University School of Medicine, Philadelphia, Pennsylvania, USA
    Neurosurgery 56:590-604. 2005
    ..A growing literature supports the benefit of COX2-specific inhibitors in treating brain injuries...
  57. pmc Group V secretory PLA2 regulates TLR2-dependent eicosanoid generation in mouse mast cells through amplification of ERK and cPLA2alpha activation
    Eriya Kikawada
    Department of Medicine, Harvard Medical School, Boston, MA, USA
    Blood 110:561-7. 2007
    Mast cells may be activated through Toll-like receptors (TLRs) for the dose- and time-dependent release of eicosanoids. However, the signaling mechanisms of TLR-dependent rapid eicosanoid generation are not known...
  58. pmc Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia
    Wenri Zhang
    Oregon Health and Science University, Department of Anesthesiology and Peri Operative Medicine, 3181 SW Sam Jackson Park Road, Portland, OR 97239 3098, USA
    Stroke 39:2073-8. 2008
    ..We tested the hypothesis that sEH gene deletion is protective against focal cerebral ischemia through enhanced collateral blood flow...
  59. ncbi Detection and quantitation of eicosanoids via high performance liquid chromatography-electrospray ionization-mass spectrometry
    Raymond Deems
    Department of Chemistry, University of California, San Diego, La Jolla, California, USA
    Methods Enzymol 432:59-82. 2007
    b>Eicosanoids constitute a large class of biologically active arachidonic acid (AA) metabolites that play important roles in numerous physiological processes...
  60. pmc Role of group V phospholipase A2 in zymosan-induced eicosanoid generation and vascular permeability revealed by targeted gene disruption
    Yoshiyuki Satake
    Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 279:16488-94. 2004
    ....
  61. ncbi A novel pathway involving progesterone receptor, 12/15-lipoxygenase-derived eicosanoids, and peroxisome proliferator-activated receptor gamma regulates implantation in mice
    Quanxi Li
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    J Biol Chem 279:11570-81. 2004
    ..both L- and E-12/15-LOX on the day of implantation resulted in a marked increase in the uterine levels of the eicosanoids, 12-HETE, 15-HETE, and 13-HODE...
  62. ncbi Vascular biology of eicosanoids and atherogenesis
    Domenico Pratico
    Temple University, Department of Pharmacology, Philadelphia, PA 19140, USA
    Expert Rev Cardiovasc Ther 7:1079-89. 2009
    ..The lipid derivatives eicosanoids have been identified as important mediators that contribute to mechanisms of atherogenesis...
  63. ncbi Impact of circulating esterified eicosanoids and other oxylipins on endothelial function
    Gregory C Shearer
    Cardiovascular Health Research Center, Sanford Research University of South Dakota, Suite 700, Sioux Falls, SD 57105, USA
    Curr Atheroscler Rep 11:403-10. 2009
    b>Eicosanoids, including epoxyeicosatrienoic acids, hydroxyeicosatetraenoic acids, and other oxylipins derived from polyunsaturated fatty acids, have emerging roles in endothelial inflammation and subsequent atherosclerosis...
  64. ncbi Electrospray ionization and tandem mass spectrometry of eicosanoids
    Robert C Murphy
    Department of Pharmacology, University of Colorado at Denver and Health Sciences Center, Mail Stop 8303, P O Box 6511, Aurora, CO 80045 0511, USA
    Anal Biochem 346:1-42. 2005
  65. ncbi Transcellular biosynthesis of eicosanoids
    Angelo Sala
    Department of Pharmacological Sciences, University of Milan, Via Balzaretti 9, 20133 Milano, Italy
    Pharmacol Rep 62:503-10. 2010
    ..express all the enzymes necessary for the production of biologically active compounds, it has been shown that eicosanoids are often the result of cell-cell interactions involving the transfer of biosynthetic intermediates, such as ..
  66. ncbi Differential effects of arachidonic and eicosapentaenoic Acid-derived eicosanoids on polymorphonuclear transmigration across endothelial cell cultures
    Juan J Moreno
    Faculty of Pharmacy, University of Barcelona, Avda Joan XXIII s n, E 08028 Barcelona, Spain
    J Pharmacol Exp Ther 331:1111-7. 2009
    ..EPA is also a substrate for arachidonic acid (AA) cascade enzymes, but it induces the production of alternative eicosanoids such as 3-series prostanoids and 5-series leukotrienes, which are considered to be less proinflammatory than AA ..
  67. ncbi In vitro effects of eicosanoids derived from different 20-carbon Fatty acids on production of monocyte-derived cytokines in human whole blood cultures
    E A Miles
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Cytokine 20:215-23. 2002
    ..Methods Human whole blood was diluted 1:5 and incubated for 48h with lipopolysaccharide. PGE and LT were added and the concentrations of inflammatory cytokines in the cell culture supernatants determined...
  68. ncbi Changes in sputum eicosanoids and inflammatory markers after inhalation challenges with occupational agents
    Mar Fernández-Nieto
    Allergy Department, Fundación Jiménez Díaz Capio and Centro de Investigacíon Biomedica en Red de Enfermedades Respiratorias, Madrid, Spain
    Chest 136:1308-15. 2009
    ..We sought to determine whether there are differences in lower airway inflammatory markers and the production of cytokines and eicosanoids between patients with a positive or negative SIC response to occupational agents.
  69. ncbi Group X secretory phospholipase A(2) induces potent productions of various lipid mediators in mouse peritoneal macrophages
    A Saiga
    Shionogi Research Laboratories, Shionogi and Co, Ltd, 12-4 Sagisu, 5-chome, Fukushima-ku, 553-0002, Osaka, Japan
    Biochim Biophys Acta 1530:67-76. 2001
    ..COX-2) by pretreatment with lipopolysaccharide, a dramatic increase in the production of these eicosanoids was observed in sPLA(2)-X-treated macrophages, which was completely blocked by the addition of either the ..
  70. pmc Macrophage migration inhibitory factor counter-regulates dexamethasone-induced annexin 1 expression and influences the release of eicosanoids in murine macrophages
    Yu Sun
    Burns Institute of Chinese PLA and Department of Burn Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China
    Immunology 140:250-8. 2013
    ..suggest that MIF counter-regulates Dex-induced annexin 1 expression, further influencing the activation of cPLA2α and the release of eicosanoids. These findings will add new insights into the mechanisms of MIF counter-regulation of GC.
  71. ncbi A novel C(28)-hydroxylated lupeolic acid suppresses the biosynthesis of eicosanoids through inhibition of cytosolic phospholipase A(2)
    Moritz Verhoff
    Department for Pharmaceutical Analytics, Pharmaceutical Institute, University of Tuebingen, Auf der Morgenstelle 8, D 72076 Tuebingen, Germany
    Biochem Pharmacol 84:681-91. 2012
    b>Eicosanoids are potent lipid mediators derived from phospholipase (PL)-released arachidonic acid (AA) coupled to subsequent metabolism by cyclooxygenase (COX)-1/2 or lipoxygenases (LO) which are involved in a variety of homeostatic ..
  72. pmc Resolution of Toll-like receptor 4-mediated acute lung injury is linked to eicosanoids and suppressor of cytokine signaling 3
    Jan N Hilberath
    Pulmonary and Critical Care Medicine, Department of Internal Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    FASEB J 25:1827-35. 2011
    ..Together, these findings indicate pivotal roles for TLR4 in promoting sterile ALI and suggest downstream provocative roles for cysteinyl leukotrienes and protective roles for SOCS3 in the intensity and duration of host responses to ALI...
  73. ncbi Changes in prostaglandin E2 and F2 alpha during vitellogenesis in the Florida crayfish Procambarus paeninsulanus
    E P Spaziani
    Department of Biology, University of South Florida, Tampa 33620 5150
    J Comp Physiol B 163:541-5. 1993
    While the role of eicosanoids in reproduction in vertebrate species has been well established, the role of these fatty acid derivatives in invertebrate species has not been as well characterized...
  74. ncbi Synovial fluid cytokines and eicosanoids as markers of joint disease in horses
    A L Bertone
    Orthopedic Research Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210-1089, USA
    Vet Surg 30:528-38. 2001
    OBJECTIVE: To evaluate the value of various synovial fluid cytokines and eicosanoids to diagnose joint disease or categories of joint disease. STUDY DESIGN: Prospective acquisition of clinicopathologic data...
  75. ncbi Eicosanoids in asthma
    Kong Sang Wan
    Department of Pediatrics, Taipei City Hospital, Ren Ai Branch, Taipei, Taiwan
    Acta Paediatr Taiwan 48:299-304. 2007
    b>Eicosanoids belong to a diverse family of bioactive fatty acids that play important roles in regulating airway inflammation and reactivity. They are the key mediators of the pathobiology of asthma...
  76. ncbi Role of eicosanoids on intestinal epithelial homeostasis
    Rut Ferrer
    Department of Physiology, University of Barcelona, Spain
    Biochem Pharmacol 80:431-8. 2010
    ..For example, eicosanoids derived from arachidonic acid are proposed as mediators involved in the regulation of epithelial structure/..
  77. ncbi Eicosanoids mediate Galleria mellonella cellular immune response to viral infection
    Ender Büyükgüzel
    Department of Biology, Faculty of Arts and Science, Karaelmas University, Zonguldak, Turkey
    J Insect Physiol 53:99-105. 2007
    ..Because eicosanoids mediate nodulation reactions to bacterial and fungal infection, we hypothesized that eicosanoids also mediate ..
  78. ncbi Eicosanoids in preeclampsia
    Scott W Walsh
    Department of Obstetrics and Gynecology, Virginia Commonwealth University, 1101 E Marshall St, PO Box 980034, Richmond, VA 23298 0034, USA
    Prostaglandins Leukot Essent Fatty Acids 70:223-32. 2004
    ..Because of the biologic actions of these two eicosanoids, this imbalance might explain major clinical symptoms of preeclampsia, such as hypertension, platelet ..
  79. ncbi Aegiceras corniculatum extract suppresses initial and late phases of inflammation in rat paw and attenuates the production of eicosanoids in rat neutrophils and human platelets
    Talat Roome
    International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan
    J Ethnopharmacol 120:248-54. 2008
    ..Blanco stems extracts and their mechanism of action against various pro-inflammatory mediators and to validate its traditional use against inflammatory diseases...
  80. ncbi Eicosanoids in exhaled breath condensates in the assessment of childhood asthma
    Bogumila Kiełbasa
    Division of Respiratory Medicine, University Children s Hospital Zurich, Zurich, Switzerland
    Pediatr Allergy Immunol 19:660-9. 2008
    The value of measurements of eicosanoids in exhaled breath condensate (EBC) for the evaluation of childhood asthma is still inconclusive most likely because of the limited value of the methods used...
  81. pmc Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations
    Susanna L Lundström
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, Stockholm, Sweden
    J Lipid Res 54:116-26. 2013
    ..was used to obtain a more comprehensive understanding of the ability of mast cell phenotypes to produce eicosanoids and other lipid mediators...
  82. ncbi Eicosanoids: an emerging role in dendritic cell biology
    Hedi Harizi
    Laboratory of Immunology, Bordeaux University, Bordeaux, France
    Arch Immunol Ther Exp (Warsz) 52:1-5. 2004
    The arachidonic acid (AA)-derived metabolites, termed eicosanoids, are potent lipid mediators with a key role in immune and inflammatory responses...
  83. ncbi Effects on plasma endotoxin and eicosanoid concentrations and serum cytokine activities in horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions
    Michelle H Barton
    Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Am J Vet Res 64:754-61. 2003
    ..To determine plasma endotoxin concentration in horses competing in a 48-, 83-, or 159-km endurance race and its importance with regard to physical, hematologic, or serum and plasma biochemical variables...
  84. ncbi Regulation of cyclooxygenase- and cytochrome p450-derived eicosanoids by heme oxygenase in the rat kidney
    Fady T Botros
    Department of Pharmacology, New York Medical College, Valhalla, NY 10595, USA
    Hypertension 39:639-44. 2002
    ..Such interactions may play an important role in the regulation of renal function...
  85. pmc Effect of gestational hypercholesterolemia and maternal immunization on offspring plasma eicosanoids
    Oswald Quehenberger
    Department of Medicine of the University of California San Diego, La Jolla, CA, USA
    Am J Obstet Gynecol 205:156.e15-25. 2011
    ....
  86. ncbi Eicosanoids: lipid mediators of inflammation in transplantation
    Paulo N Rocha
    Department of Medicine, Division of Nephrology, Duke University and Durham VA Medical Centers, Building 6 Nephrology, 508 Fulton Street, Durham, NC 27705, USA
    Springer Semin Immunopathol 25:215-27. 2003
    b>Eicosanoids are a family of lipid mediators derived from the metabolism of arachidonic acid. Eicosanoids, such as prostanoids and leukotrienes, have a wide range of biological actions including potent effects on inflammation and immunity...
  87. ncbi Profile of eicosanoids in breath condensate in asthma and COPD
    Leandro Genehr Fritscher
    Potificia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
    J Breath Res 6:026001. 2012
    The collection of exhaled breath condensates (EBC) is a noninvasive method for obtaining samples from the lungs. Eicosanoids are lipid mediators implicated in the asthmatic inflammatory response...
  88. ncbi Involvement of eicosanoids in the hypothermic response to lipopolysaccharide during endotoxemia in rats
    Abed N Azab
    Department of Clinical Pharmacology, Faculty of Health Sciences, Ben Gurion University of the Negev, P O Box 653, 84105 Beer Sheva, Israel
    Prostaglandins Leukot Essent Fatty Acids 70:67-75. 2004
    ..We conclude that in rats, febrile response to endotoxin involves many inflammatory mediators. However, it seems that PGE(2) and leukotrienes do not have a pivotal role in the mechanism of LPS-induced mortality...
  89. ncbi Eicosanoids: mediators and therapeutic targets in fibrotic lung disease
    Ryan P Charbeneau
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109 0642, USA
    Clin Sci (Lond) 108:479-91. 2005
    ..b>Eicosanoids are lipid mediators derived from arachidonic acid, the most studied of which are the prostaglandins and ..
  90. pmc Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1
    Samia Yazid
    Biochemical Pharmacology, William Harvey Research Institute, Bart s and The London School of Medicine and Dentistry, London, UK
    Biochem Pharmacol 77:1814-26. 2009
    ..1.3.16), which probably forms part of a control loop to limit Anx-A1 release. These experiments provide a basis for a novel mechanism of action for the cromolyns, a group of drugs that have long puzzled investigators...
  91. ncbi Systematic evaluation of transcellular activities of secretory phospholipases A2. High activity of group V phospholipases A2 to induce eicosanoid biosynthesis in neighboring inflammatory cells
    Gihani T Wijewickrama
    Department of Chemistry, University of Illinois, Chicago, Illinois 60607, USA
    J Biol Chem 281:10935-44. 2006
    ....
  92. ncbi Eicosanoids and adipokines in breast cancer: from molecular mechanisms to clinical considerations
    Samar Basu
    Biochemistry, Molecular Biology and Nutrition, University of Auvergne, Clermont Ferrand, France
    Antioxid Redox Signal 18:323-60. 2013
    ..Various signaling products of transcription factor, nuclear factor-kappaB, in particular inflammatory eicosanoids, reactive oxygen species (ROS), and cytokines, are thought to be involved in chronic inflammation-induced ..
  93. ncbi TLR-4 and sustained calcium agonists synergistically produce eicosanoids independent of protein synthesis in RAW264.7 cells
    Matthew W Buczynski
    Department of Chemistry and Biochemistry, School of Medicine, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 282:22834-47. 2007
    ..investigation of these biological processes requires the simultaneous quantitation of a large number of eicosanoids in a single analysis...
  94. pmc Insulin-containing lipogenic stimuli suppress mast cell degranulation potential and up-regulate lipid body biogenesis and eicosanoid secretion in a PPARγ-independent manner
    William E Greineisen
    Laboratory of Immunology and Signal Transduction, Chaminade University, Honolulu, HI 96816, USA
    J Leukoc Biol 92:653-65. 2012
    ..Thus, chronic exposure to metabolic stimuli, such as insulin, may be a determinant of the proinflammatory potential of the mast cell...
  95. ncbi Increased release of arachidonic acid and eicosanoids in iron-overloaded cardiomyocytes
    R Mattera
    Rammelkamp Center for Education and Research, MetroHealth Medical Center, Department of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Circulation 103:2395-401. 2001
    ....
  96. pmc Composition of fatty acids in plasma and erythrocytes and eicosanoids level in patients with metabolic syndrome
    Tatyana P Novgorodtseva
    Vladivostok Branch of the Far Eastern Center of Physiology and Pathology of Respiration of SB RAMN Institute of Medical Climatology and Rehabilitative Treatment, Russia
    Lipids Health Dis 10:82. 2011
    ..Disturbances of the fatty acids composition in plasma and red blood cells and eicosanoid synthesis play an important role in the metabolic syndrome (MS) formation...
  97. ncbi Effect of dietary fat and omega-3 fatty acids on urinary eicosanoids and sex hormone concentrations in postmenopausal women: a randomized controlled feeding trial
    Lindsay R Young
    Department of Food Science and Nutrition, University of Minnesota, St Paul, Minnesota, USA
    Nutr Cancer 63:930-9. 2011
    ..effects of dietary fat and n-3 FA intake on breast cancer risk markers, circulating sex hormones and urinary eicosanoids were measured in response to controlled feeding of diets designed to increase plasma concentrations of n-3 FA...
  98. ncbi High-dose methylprednisolone and 'ex vivo' release of eicosanoids after experimental subarachnoid haemorrhage
    P Gaetani
    Department of Surgery, IRCCS Policlinico S Matteo, Pavia, Italy
    Neurol Res 12:111-6. 1990
    ..investigated the effects of high-dose methylprednisolone (MP) treatment on the 'ex vivo' release of four major eicosanoids in an experimental model of subarachnoid haemorrhage (SAH) with the aim of verifying: (a) the efficacy in ..
  99. ncbi Eicosanoids in prevention and management of diseases
    J Szefel
    Department of Surgical Oncology, Gdynia Oncology Centre, PCK s Maritime Hospital in Gdynia, Poland
    Curr Mol Med 11:13-25. 2011
    b>Eicosanoids, which originate from polyunsaturated fatty acids (PUFAs), have a major impact on homeostasis maintenance as secondary signal transducers...
  100. ncbi Identification of eicosanoids in the red algae, Gracilaria asiatica, using high-performance liquid chromatography and electrospray ionization mass spectrometry
    J Sajiki
    Public Health Laboratory of Chiba Prefecture, Japan
    J Chromatogr A 795:227-37. 1998
    Identification of eicosanoids which are metabolites of arachidonic acid in red algae Gracilaria asiatica, one of the popular seaweeds in Japan, was carried out using high-performance liquid chromatography (HPLC) interfaced with ..
  101. pmc Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
    Charles N Serhan
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:349-61. 2008
    ..presents new cellular and molecular mechanisms for the resolution of inflammation, revealing key roles for eicosanoids, such as lipoxins, and recently discovered families of endogenous chemical mediators, termed resolvins and ..

Research Grants72

  1. OXIDANT STRESS AND ENDOTHELIAL CELL METABOLISM
    LORRAINE SORDILLO; Fiscal Year: 2001
    ..oxidant stress, a potential consequence of inadequate selenium (Se) nutrition, can influence the synthesis of eicosanoids by endothelial cells...
  2. Integrated signaling of eicosanoids in HSC formation and regeneration
    Trista E North; Fiscal Year: 2013
    ..In contrast, the function of related eicosanoids, cannabinoids (CB), in HSC development and PGE2-mediated repair has not been addressed...
  3. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exists in virtually every organ and tissue of humans...
  4. NITROGEN HETEROCYCLES: METABOLIC EFFECTS AND TOXICITY
    Raymond F Novak; Fiscal Year: 2010
    ..health, because it increases oxidative stress, catalyzes the metabolism of carcinogens, therapeutic agents, eicosanoids, and fatty acids, reflects an altered phenotype, and is a biomarker of progressive hepatic disease development ..
  5. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2013
    ..adipose tissue from FABP null mice and FABP null macrophage cell lines exhibit reduced levels of inflammatory eicosanoids. Treatment of macrophages with leukotrienes results in an increase in iNOS and MCP1 expression while decreasing ..
  6. Lipid Binding Proteins in Obesity and Diabetes Syndromes
    David A Bernlohr; Fiscal Year: 2011
    ..adipose tissue from FABP null mice and FABP null macrophage cell lines exhibit reduced levels of inflammatory eicosanoids. Treatment of macrophages with leukotrienes results in an increase in iNOS and MCP1 expression while decreasing ..
  7. Fatty Acids, Eicosanoids and Inflammation
    Eric K Long; Fiscal Year: 2012
    ....
  8. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
    ..of cPLA2[unreadable]-induced NADPH oxidase activity and ROS production;and 7) HPLC-LC-ESI-MS to measure eicosanoids and other possible AA metabolites...
  9. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Based on these novel observations, we predict that eicosanoids, particularly the 15-LOX product of AA, namely, 15(S)-HETE via its capacity to perturb EC barrier function ..
  10. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    ..fatty acid oxygenation to undertake research focused on the pharmacology, biochemistry, and biology of eicosanoids and related compounds...
  11. PPAR gamma Agonists for Lung Cancer Chemoprevention
    Robert Keith; Fiscal Year: 2013
    ..We have found that the balance of these eicosanoids is pivotal in lung tumorigenesis...
  12. Adiposity and Outcomes of Clinically Localized Prostate Cancer
    Vincent L Freeman; Fiscal Year: 2013
    ..to be studied include fatty acids, the IGF-1 receptor signaling pathway, adipose tissue-derived cytokines, eicosanoids products of arachidonic acid, and metabolites of estrogen and testosterone...
  13. Participation in Cytochrome b5 in Anesthetic Metabolism
    Lucy A Waskell; Fiscal Year: 2010
    ..all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exist in virtually every organ and tissue of humans...
  14. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..Here the aim is to study how disruption of a microvascular vasodilator pathway could cause delayed microvascular spasm after subarachnoid hemorrhage and subsequently, delayed neurological deficit. ..
  15. CD36 and Intestinal Fat Absorption
    Nada A Abumrad; Fiscal Year: 2013
    ..is also involved in CD36-mediated regulation of the synthesis of arachidonic acid derived pro- inflammatory eicosanoids. Our hypothesis is that during early absorption the CD36-ERK signaling pathway functions to initiate in ..
  16. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2013
    ..In this proposal we will investigate the mechanism of action of eicosanoids in facilitating collection of stem cells and enhancing their engraftment and self-renewal upon transplantation...
  17. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..suggests that resolution of the inflammatory response is regulated by sequential changes in the production of eicosanoids generated from arachidonic acid via cyclooxygenase-2 and lipoxygenase...
  18. Apoptosis and efferocytosis: regulators of immunity to tuberculosis
    Samuel M Behar; Fiscal Year: 2013
    ..Innovation: The role of eicosanoids in immunity to mycobacteria is conserved in fish, mice and humans, highlighting their fundamental importance...
  19. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..We hypothesize that eicosanoids modulate both the acute and chronic host responses to LTX injury, with PGs preserving vascular homeostasis and ..
  20. EICOSANOIDS AND VASCULAR WALL REMODELING
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Based on these novel observations, we predict that eicosanoids, particularly the 15- LOX1/2 product of AA, 15(S)-HETE, via its capacity to trigger the migration and adhesion ..
  21. Long-Chain Fatty Acids, Oxidative Stress and Colorectal Neoplasm Risk
    Harvey J Murff; Fiscal Year: 2013
    ..have an increased risk of colorectal adenoma and that this increased risk is mediated through pro-inflammatory eicosanoids and increased oxidative stress...
  22. Effect of Alcohol on Obesity Related Liver Disease
    Arun J Sanyal; Fiscal Year: 2013
    ..in obese subjects by (a) relating alcohol-induced changes in circulating gut microbiome-derived metabolites and eicosanoids to pathways driving fatty liver disease, and changes in intestinal permeability in obese subjects, (b) ..
  23. Training Grant in Inflammatory and Fibrosing Diseases
    Gary S Gilkeson; Fiscal Year: 2013
    ..pathways leading to fibrosis, matrix proteins, scleroderma lung disease, sphingolipids, proteomics and eicosanoids. Trainees have the option of...
  24. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..Among the substances elaborated during infection, lipid mediators derived from arachidonate (eicosanoids), including leukotrienes (LTs) B4 (LTB4) and D4 (LTD4) as well as prostaglandin E2 (PGE2), have emerged as ..
  25. Weight Loss &Cancer Biomarkers in Women: 0xidative Stress &Inflammation
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..Oxidative stress, inflammation, and eicosanoids, which are involved in several phases of carcinogenesis and tumor progression, have been associated with risk ..
  26. Anesthesiology Research Training Program
    Judy R Kersten; Fiscal Year: 2013
    ..g. molecular genetics, angiogenesis, ion channels, cell physiology, adhesion molecules, eicosanoids, exercise and respiratory physiology, hypertension, autonomic nervous system, nitric oxide synthase, ..
  27. HORMONAL REGULATION OF BLOOD PRESSURE
    Michal Laniado Schwartzman; Fiscal Year: 2013
    ..of this Program Project Grant continues to concentrate on the role of the cytochrome P450 (CYP)-derived eicosanoids in the regulation of renal and vascular function and in the control of blood pressure...
  28. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The major objective of my proposal is to investigate the interaction of eicosanoids, specifically the cyclooxygenase (COX)-prostanoid system, with the heme oxygenase (HO)-carbon monoxide (CO) system ..
  29. Stress and Proinflammatory Cytokines: Omega-3 Intervention
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ..Diet also influences the synthesis of these cytokines. Arachidonic acid (AA) derived (omega-6 or n-6) eicosanoids (primarily from refined vegetable oils such as corn, sunflower, and safflower) increase the production of these ..
  30. Role of Eicosanoids in Renal Function
    NANCY JOAN BROWN; Fiscal Year: 2013
    ..This application proposes to build upon these studies and to address: a) mechanisms by which the P450-eicosanoids regulate renal tubular transport and vascular reactivity, b) the role of P450s in human hypertension and renal ..
  31. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    ..from membrane phospholipids by phospholipase A2 (PLA2), is converted to oxidized lipids collectively known as eicosanoids, including prostaglandins and leukotrienes (LT), through the cyclooxygenase (COX) and lipoxygenase (LO) ..
  32. Enzyme Environmental Effects in Complex Cytochrome P450-Catalyzed Reactions
    John C Hackett; Fiscal Year: 2013
    ..P450 enzymes (CYPs) are essential for the biosynthesis of numerous natural products, steroid hormones, and eicosanoids, as well as the clearance of most drugs...
  33. Mechanism of Vascular Dysfunction after Stroke in Postmenopausal Female
    Nabil J Alkayed; Fiscal Year: 2013
    ..in reproductively senescent mice are linked to reduced signaling by endothelium-derived cytochrome P450 (CYP) eicosanoids called epoxyeicosatrienoic acids (EETs)...
  34. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2013
    ..The phospholipase A2s (PLA2)s are a group of enzymes that catalyze the rate-limiting step in the formation of eicosanoids such as leukotrienes (LT)s and prostaglandins (PG)s...
  35. BLOOD CELL LIPOXYGENASE PRODUCTS--FORMATION AND ACTION
    CHARLES NICHOLAS SERHAN; Fiscal Year: 2013
    ..To address this, 4 specific aims are proposed to establish 1) the temporal relationships between eicosanoids and SPM produced in resolution versus non-resolving inflammation in murine exudates;2) identify novel SPM pro-..
  36. Oxidized lipids and UV immunosuppression
    Jeffrey B Travers; Fiscal Year: 2013
    ..effects via a complex interplay of cell types and cytokines including mast cells, cyclooxygenase-2-produced eicosanoids, interleukin-10 and histamine...
  37. Role of phospholipase A2 in spinal cord secondary injury
    Xiao Ming Xu; Fiscal Year: 2013
    ..These products are precursors of bioactive eicosanoids and platelet activating factor (PAF) that are well-known mediators of inflammation, oxidation and cytotoxicity...
  38. CYTOPLASMIC LIPID BODIES OF INFLAMMATORY CELLS
    Peter F Weller; Fiscal Year: 2013
    ..lipid bodies contain all enzymes required for synthesizing cyclooxygenase (COX)- and lipoxygenase (LO)-derived eicosanoids. Lipid body formation, rapidly inducible in vitro and in vivo by specific intracellular signaling pathways, ..
  39. Aging, Stress, Fatty Acids and Inflammation
    Janice K Kiecolt Glaser; Fiscal Year: 2010
    ..Diet also influences the synthesis of these cytokines. Arachidonic acid (AA) derived (omega-6 or n-6) eicosanoids increase the production of these cytokines...
  40. Convergence of the COX-2 and 5-lipoxygenase pathways
    Claus Schneider; Fiscal Year: 2013
    ..the 5-LOX and COX-2 enzymes could be acting in tandem resulting in the biosynthesis of previously unrecognized eicosanoids: Consecutive oxygenation of AA by 5-LOX and COX-2 gives an unstable di- endoperoxide that rearranges to two ..
  41. Regulation and Function of Cytosolic Phospholipase A2
    Michael H Gelb; Fiscal Year: 2012
    b>Eicosanoids mediate a wide variety of physiological processes including inflammation. These lipid mediators are oxygenated metabolites of arachidonic acid and other poly- unsaturated fatty acids...
  42. Role of Lipid Droplet Proteins in Islet Function in Diabetes and Obesity
    Yumi Imai; Fiscal Year: 2013
    ..The change in cholesterol metabolism and eicosanoids production will be analyzed after modulating ADFP levels in MIN6 cells and mouse islets as above...
  43. Eicosanoid regulation of experimental Lyme arthritis
    Charles R Brown; Fiscal Year: 2010
    ..COX-2 is part of a complex system of eicosanoids that regulate the development and resolution of inflammatory responses...
  44. Cerebrovascular mechanisms in methamphetamine-mediated exacerbation of neuroAIDS
    Stephen Dewhurst; Fiscal Year: 2012
    ..underlying mechanism by testing whether MA-induced hypoperfusion is due to the induction of specific vasoactive eicosanoids, and in Aim 1C, we will determine whether chronic MA exposure elicits a sustained reduction in CBF in wild-type ..
  45. Genes of the CYP450-Derived Eicosanoids Pathway in Subclinical Atherosclerosis
    Myriam Fornage; Fiscal Year: 2010
    ..CYP450-derived eicosanoids play an important role in cardiovascular function and may be intimately involved in pathogenesis of ..
  46. Eicosanoids in Lung Cancer: Progression and Metastasis
    Raphael A Nemenoff; Fiscal Year: 2013
    ..cPLA2 represents the rate-limiting step in production of a family of eicosanoids with diverse affects in cancer progression...
  47. Structure and Function of P450 Enzymes in Steroid Hormone Biosynthesis
    Martin Egli; Fiscal Year: 2013
    ..g., drugs, carcinogens) and endogenous substrate biosynthesis (e.g., hormones, eicosanoids)...
  48. Cytochrome P450 Eicosanoids and Myocardial Injury
    GARRETT JOHN GROSS; Fiscal Year: 2012
    ..Thus, in the ongoing research plan, we will investigate the mechanistic actions of EETs in cellular systems such as cardiomyocytes (HL-1 cells, rat cardiomyocytes) and in gene knockout or overexpressing mice. ..
  49. Phospholipid-Arachidonate-Eicosanoid Signaling in Schizophrenia
    Jeffrey K Yao; Fiscal Year: 2013
    ..we propose that abnormalities involving arachidonic acid and related metabolites (collectively termed eicosanoids) are fundamental to at least one physiological subtype of schizophrenia...
  50. The Role of Bioactive Lipids in Inflammation and Cancer
    RAYMOND NELSON DUBOIS; Fiscal Year: 2013
    ..In addition, bioactive lipids play a key role in inflammation and carcinogenesis. Bioactive lipids such as eicosanoids, endocannabinoids, sphingolipids, and ceramides can initiate complex signaling networks that affect ..
  51. Lipidomic mapping of the cellular anatomy of brain endocannabinoid metabolism
    Andreu Viader; Fiscal Year: 2013
    ..distribution of these two enzymes in the nervous system and assess how their inactivation alters pools of eCBs/eicosanoids basally and in experimental paradigms of neuroinflammation...
  52. Biochemical Studies of 14-kDa Phospholipases A2
    Michael H Gelb; Fiscal Year: 2013
    ..The eicosanoids are biosynthesized from arachidonic acid, which is liberated from the cellular phospholipids by a family of ..
  53. Cytochrome P450 Derived Eicosanoids and Inflammation
    Craig R Lee; Fiscal Year: 2013
    ..abstract_text> ..
  54. The Role of Ceramide Kinase in Eicosanoid Synthesis
    Charles E Chalfant; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Products of arachidonic acid (AA), eicosanoids, are well-established mediators of inflammation...
  55. Modulating Eicosanoids to Treat Tuberculosis: Personalized, Host-directed Therapy
    David M Tobin; Fiscal Year: 2011
    ..the LTA4H enzyme functions as a rheostat, controlling relative levels of specific pro- and anti- inflammatory eicosanoids. We found that common LTA4H polymorphisms in human populations control susceptibility to TB and leprosy...
  56. Novel Eicosanoids: Synthesis and Function
    John R Falck; Fiscal Year: 2012
    ..Known collectively as eicosanoids, the primary metabolites are subject to a further cascade of enzymatic and non- enzymatic transformations ..
  57. Nucleotide receptor modulation of airway eicosanoids during asthma exacerbations
    Loren C Denlinger; Fiscal Year: 2013
    ....
  58. Eicosanoids and Intestinal Epithelial Growth Regulation
    RAYMOND NELSON DUBOIS; Fiscal Year: 2012
    ..It is becoming clear that just targeting one single molecule will not be as effective as needed to have a significant impact on this disease. ..
  59. The Role of Eicosanoids in Shock
    James A Cook; Fiscal Year: 2013
    ..New knowledge derived from these studies may reveal innovative therapeutic strategies to treat polymicrobial sepsis that will have high translational value. ..
  60. CYP 450-mediated CBF Dysregulation and Neurotoxicity in Pediatric Cardiac Arrest
    Mioara D Manole; Fiscal Year: 2013
    ..Furthermore, inhibiting the production of vasoconstrictive eicosanoids prevented the cortical hypoperfusion and improved neurological outcome in our pediatric asphyxial cardiac ..
  61. Specificity and in vivo function of the Naip/Nlrc4 inflammasomes
    Russell E Vance; Fiscal Year: 2013
    ..b>Eicosanoids are known to be critical mediators of inflammation, but their production has not previously been linked to ..
  62. Microsomal Prostaglandin E Synthase in Rheumatoid Arthritis
    Leslie J Crofford; Fiscal Year: 2013
    ..We will determine the role for mPGES-1-derived PGE2 in comparison with other eicosanoids for initiation and progression of inflammation and immunity...
  63. An intracellular signaling switch for maintaining peripheral sensitization
    Michael R Vasko; Fiscal Year: 2013
    ..the acute sensitizing actions of prostaglandins, there is little understanding of the mechanisms by which these eicosanoids can maintain peripheral sensitization...
  64. SEROTONIN AND EICOSANOID INTERACTION IN LUNG VASOMOTION
    WENDELL HOFMAN; Fiscal Year: 1992
    ..Which pathways or products of AA metabolism (i.e. eicosanoids) account for this pulmonary hypertension is not clear...
  65. LUNG VASCULAR EFFECTS OF HIGH FREQUENCY VENTILATION
    MUKUL BANERJEE; Fiscal Year: 1992
    ..The working hypothesis is that vasoactive substances, eicosanoids and atrial natriuretic factor (ANF) are released during substances can influence cardiac output, pulmonary and ..
  66. GI-Safer Naproxen Formulation R&D for the Treatment of Osteoarthritis and Related
    Upendra Marathi; Fiscal Year: 2009
    ..Naproxen-PC may have enhanced anti-inflammatory efficacy, as reflected in the attenuation of pro-inflammatory eicosanoids (including prostaglandin E2 (PGE2), leukotriene B4 (LTB4), 12- hydroxyeicosatetraenoic acid (12-HETE), and 5-..
  67. DETERMINANTS OF LUNG MACROPHAGE ARACHIDONATE METABOLISM
    Marc Peters Golden; Fiscal Year: 1990
    Arachidonic acid metabolites, eicosanoids, play important roles in the pathogenesis of lung inflammation and injury...
  68. MEMBRANE LIPIDS AND THEIR POTENTIAL ROLE IN LUPUS
    THOMAS SANTORO; Fiscal Year: 1992
    ..Treatment regiments which alter the production or tissue levels of eicosanoids suggest that lipoxygenase metabolites have a permissive effect on the expression of autoimmunity...
  69. EICOSANOID OXIDATION BY LIVER AND KIDNEY P450 ENZYMES
    Jerome Lasker; Fiscal Year: 2006
    ..including long-chain fatty acid such as arachidonic acid (AA), leukotrienes (LT) such as LTB4, and other eicosanoids. P450-mediated oxidation of these lipid-derived endobiotics results in products with potent effects on ion ..
  70. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2004
    ..These CYP-derived eicosanoids are of interest since they are endogenous constituents of numerous tissues and posses a wide array of ..
  71. LIPID METABOLISM IN STIMULATED HUMAN PLATELETS
    M Broekman; Fiscal Year: 1991
    ..The regulation of levels of free arachidonate is also important for formation of other biologically active eicosanoids since a) endothelial cells utilize plateletderived arachidonate to generate anti- aggregatory prostacyclin, b) ..
  72. Eosinophil Lipid Bodies in Allergic Inflammation
    Peter Weller; Fiscal Year: 2004
    ..Among mediators pertinent to allergic inflammation, eosinophils are sources of eicosanoids, including cysteinyl leukotrienes...