prostaglandins f

Summary

Summary: (9 alpha,11 alpha,13E,15S)-9,11,15-Trihydroxyprost-13-en-1-oic acid (PGF(1 alpha)); (5Z,9 alpha,11,alpha,13E,15S)-9,11,15-trihydroxyprosta-5,13-dien-1-oic acid (PGF(2 alpha)); (5Z,9 alpha,11 alpha,13E,15S,17Z)-9,11,15-trihydroxyprosta-5,13,17-trien-1-oic acid (PGF(3 alpha)). A family of prostaglandins that includes three of the six naturally occurring prostaglandins. All naturally occurring PGF have an alpha configuration at the 9-carbon position. They stimulate uterine and bronchial smooth muscle and are often used as oxytocics.

Top Publications

  1. ncbi New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents
    Tadashi Nakajima
    Glaucoma Group, Research and Development Center, Santen Pharmaceutical Co Ltd Nara, Japan
    Biol Pharm Bull 26:1691-5. 2003
  2. pmc Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction
    Johnathan W Edmonds
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Dev Cell 19:858-71. 2010
  3. ncbi Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug
    Yasutaka Takagi
    Glaucoma Group, Research and Development Center, Santen Pharmaceutical Co, Ltd, 8916 16, Takayama cho, Ikoma 630 0101, Nara, Japan
    Exp Eye Res 78:767-76. 2004
  4. ncbi Twenty-four-hour ocular hypotensive effects of 0.0015% tafluprost and 0.005% latanoprost in healthy subjects
    Hideki Mochizuki
    Department of Ophthalmology and Visual Science, Graduate School of Biomedical Science, Hiroshima University, Minami Ku, Hiroshima, Japan
    Jpn J Ophthalmol 54:286-90. 2010
  5. ncbi Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study
    Hannu Uusitalo
    Department of Ophthalmology, Tampere University Hospital, University of Tampere, Tampere, Finland
    Acta Ophthalmol 88:12-9. 2010
  6. ncbi Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication
    Hannu Uusitalo
    University of Tampere and Tampere University Hospital, Finland
    Acta Ophthalmol 88:329-36. 2010
  7. ncbi A phase II study on the duration and stability of the intraocular pressure-lowering effect and tolerability of Tafluprost compared with latanoprost
    Carlo E Traverso
    Centro di Ricerca Clinica e Laboratorio per il Glaucoma e la Cornea, DiNOG, Clinica Oculistica University of Genova, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    J Ocul Pharmacol Ther 26:97-104. 2010
  8. pmc Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
    H Liang
    Department of Toxicology, Faculty of Biological and Pharmacological Sciences, University Paris Descartes, Paris, France
    Br J Ophthalmol 92:1275-82. 2008
  9. ncbi In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line
    Emmanuelle Brasnu
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Curr Eye Res 33:303-12. 2008
  10. ncbi A comparative, placebo-controlled study of prostanoid fluoroprostaglandin-receptor agonists tafluprost and latanoprost in healthy males
    Andrew Sutton
    Guildford Clinical Pharmacology Ltd, Guildford, Surrey, United Kingdom
    J Ocul Pharmacol Ther 23:359-65. 2007

Research Grants

Detail Information

Publications165 found, 100 shown here

  1. ncbi New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents
    Tadashi Nakajima
    Glaucoma Group, Research and Development Center, Santen Pharmaceutical Co Ltd Nara, Japan
    Biol Pharm Bull 26:1691-5. 2003
    ..Hence, AFP-168 may be worthy of further evaluation as an ocular-hypotensive agent...
  2. pmc Insulin/FOXO signaling regulates ovarian prostaglandins critical for reproduction
    Johnathan W Edmonds
    Department of Cell Biology, University of Alabama at Birmingham, 35294, USA
    Dev Cell 19:858-71. 2010
    ..Prostaglandins may be conserved sperm guidance factors and widespread downstream effectors of insulin actions that influence both reproductive and nonreproductive processes...
  3. ncbi Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug
    Yasutaka Takagi
    Glaucoma Group, Research and Development Center, Santen Pharmaceutical Co, Ltd, 8916 16, Takayama cho, Ikoma 630 0101, Nara, Japan
    Exp Eye Res 78:767-76. 2004
    ....
  4. ncbi Twenty-four-hour ocular hypotensive effects of 0.0015% tafluprost and 0.005% latanoprost in healthy subjects
    Hideki Mochizuki
    Department of Ophthalmology and Visual Science, Graduate School of Biomedical Science, Hiroshima University, Minami Ku, Hiroshima, Japan
    Jpn J Ophthalmol 54:286-90. 2010
    ..To compare the intraocular pressure (IOP) reduction over 24 h achieved with tafluprost (0.0015%) with that achieved with latanoprost (0.005%)...
  5. ncbi Efficacy and safety of tafluprost 0.0015% versus latanoprost 0.005% eye drops in open-angle glaucoma and ocular hypertension: 24-month results of a randomized, double-masked phase III study
    Hannu Uusitalo
    Department of Ophthalmology, Tampere University Hospital, University of Tampere, Tampere, Finland
    Acta Ophthalmol 88:12-9. 2010
    ..The objective of the study was to compare the long-term efficacy and safety of tafluprost 0.0015% with latanoprost 0.005% eye drops in patients with open-angle glaucoma or ocular hypertension...
  6. ncbi Switching from a preserved to a preservative-free prostaglandin preparation in topical glaucoma medication
    Hannu Uusitalo
    University of Tampere and Tampere University Hospital, Finland
    Acta Ophthalmol 88:329-36. 2010
    ....
  7. ncbi A phase II study on the duration and stability of the intraocular pressure-lowering effect and tolerability of Tafluprost compared with latanoprost
    Carlo E Traverso
    Centro di Ricerca Clinica e Laboratorio per il Glaucoma e la Cornea, DiNOG, Clinica Oculistica University of Genova, Azienda Ospedaliera Universitaria San Martino, Genova, Italy
    J Ocul Pharmacol Ther 26:97-104. 2010
    ..We investigated the efficacy, safety, and tolerability of tafluprost 0.0015% compared with latanoprost 0.005% in patients with primary open-angle glaucoma, exfoliation glaucoma, or ocular hypertension...
  8. pmc Conjunctival and corneal reactions in rabbits following short- and repeated exposure to preservative-free tafluprost, commercially available latanoprost and 0.02% benzalkonium chloride
    H Liang
    Department of Toxicology, Faculty of Biological and Pharmacological Sciences, University Paris Descartes, Paris, France
    Br J Ophthalmol 92:1275-82. 2008
    ..To compare the conjunctival and corneal reactions of commercially available solution of latanoprost (Xalatan) and preservative-free (PF) tafluprost in rabbits...
  9. ncbi In vitro effects of preservative-free tafluprost and preserved latanoprost, travoprost, and bimatoprost in a conjunctival epithelial cell line
    Emmanuelle Brasnu
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Curr Eye Res 33:303-12. 2008
    ....
  10. ncbi A comparative, placebo-controlled study of prostanoid fluoroprostaglandin-receptor agonists tafluprost and latanoprost in healthy males
    Andrew Sutton
    Guildford Clinical Pharmacology Ltd, Guildford, Surrey, United Kingdom
    J Ocul Pharmacol Ther 23:359-65. 2007
    ..The aim of this study was to determine the safety, tolerability, and pharmaco-dynamics of a novel prostanoid fluoroprostaglandin (FP)-receptor agonist, tafluprost (AFP-168), in healthy males...
  11. pmc The IOP-lowering effects and mechanism of action of tafluprost in prostanoid receptor-deficient mice
    Takashi Ota
    Department of Ophthalmology, University of Tokyo School of Medicine, 7 3 1 Hongo Bunkyo ku Tokyo 113 8655, Japan
    Br J Ophthalmol 91:673-6. 2007
    ..To clarify the intraocular pressure (IOP)-lowering profile of tafluprost, a newly synthesised prostaglandin F(2alpha) analogue, in mice...
  12. ncbi Prostaglandin analogues and mouse intraocular pressure: effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation
    Takashi Ota
    Department of Ophthalmology, University of Tokyo School of Medicine, Japan
    Invest Ophthalmol Vis Sci 46:2006-11. 2005
    ....
  13. ncbi Efficacy and safety levels of preserved and preservative-free tafluprost are equivalent in patients with glaucoma or ocular hypertension: results from a pharmacodynamics analysis
    Thomas Hamacher
    Augenzentrum Dr Hamacher Praxis, Maximilianstrasse 2B, Starnberg, Germany
    Acta Ophthalmol Suppl (Oxf ) 242:14-9. 2008
    ..Tafluprost is a new prostaglandin F(2alpha) (PGF(2alpha)) derivative in development for the treatment of glaucoma. Tafluprost is the first PGF(2alpha) analogue with a preservative-free formulation...
  14. ncbi IOP-lowering efficacy and tolerability of preservative-free tafluprost 0.0015% among patients with ocular hypertension or glaucoma
    Anton Hommer
    Sanatorium Hera, Vienna, Austria
    Curr Med Res Opin 26:1905-13. 2010
    ..Major objectives of this study were to evaluate the real world efficacy, local tolerability and safety of this first in class preservative-free prostaglandin preparation in patients with ocular hypertension and glaucoma...
  15. ncbi Retinol and estradiol regulation of retinol binding protein and prostaglandin production by porcine uterine epithelial cells in vitro
    P G Groothuis
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506, USA
    J Anim Sci 80:2688-94. 2002
    ..05) RBP and decreased (P < 0.05) PG production by LEC in vitro. Therefore responses to E2 and retinol differ between pre- and post-pubertal females, and retinol may function in the regulation of endometrial RBP and PG secretion...
  16. ncbi Presynchronization with gonadotropin-releasing hormone does not improve fertility in Holstein heifers
    H Rivera
    Department of Dairy Science, University of Wisconsin, Madison, Wisconsin 53706, USA
    J Dairy Sci 89:3810-6. 2006
    ....
  17. ncbi Effect of flunixin meglumine on selected physiologic and performance parameters of athletically conditioned thoroughbred horses subjected to an incremental exercise stress test
    Patrick T Colahan
    Department of Large Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610, USA
    Vet Ther 3:37-48. 2002
    ..Exercise did not change the flunixin elimination profile in either serum or urine, and concentrations were found to be below the detection limit of the ELISA test within 36 hours in serum and 120 hours in urine...
  18. ncbi Nitric oxide, anti-inflammatory drugs on renal prostaglandins and cyclooxygenase-2
    Masaru Miyataka
    Huntington Medical Research Institutes, Department of Experimental Cardiology, Pasadena, Cal 91101, USA
    Hypertension 39:785-9. 2002
    ..PGI2 and COX-2 protein were mainly expressed in the renal medulla, whereas iNOS expression was greater in the cortex. B-NOD preserved renal prostacyclin levels after administration of NSAIDs...
  19. ncbi Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming growth factor alpha
    R Manchanda
    Reproductive Biology Unit, Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa Health Research Institute, The Ottawa Hospital (Civic Campus, Ottawa, Ontario, Canada K1Y 4E9
    Reproduction 122:91-101. 2001
    ..Whether arachidonic acid or leukotrienes are important in the anti-apoptotic action of TGF-alpha in hen granulosa cells remains to be determined...
  20. pmc Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis
    F M Giardiello
    Department of Medicine, Oncology Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Dig Dis Sci 43:311-6. 1998
    ....
  21. ncbi Fetal responses to maternal and intra-amniotic lipopolysaccharide administration in sheep
    Peta L Grigsby
    Fetal and Neonatal Research Group, Department of Physiology, Monash University, Clayton, Victoria 3800, Australia
    Biol Reprod 68:1695-702. 2003
    ..The attenuated fetal response to intra-amniotic LPS treatment, despite the much higher dose used, may support a role for the amniotic fluid in protecting the fetus from endotoxin exposure during pregnancy...
  22. ncbi Effects of estradiol cypionate (ECP) on ovarian follicular dynamics, synchrony of ovulation, and fertility in CIDR-based, fixed-time AI programs in beef heifers
    Marcos German Colazo
    Department of Large Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, SK, Canada S7N 5B4
    Theriogenology 60:855-65. 2003
    ..5mg ECP (at CIDR removal or 24h later) induced a synchronous ovulation with an acceptable pregnancy rate to fixed-time AI...
  23. ncbi The use of estradiol and/or GnRH in a two-dose PGF protocol for breeding management of beef heifers
    M F Martinez
    Western College of Veterinary Medicine, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, Canada S7N 5B4
    Theriogenology 62:363-72. 2004
    ..A combination of estrus detection and timed-AI in a two-dose PGF protocol resulted in highly acceptable pregnancy rates...
  24. ncbi Role of eicosanoids of the contralateral kidney in maintenance of two-kidney, one-clip renovascular hypertension in rats
    Christos Kalaitzis
    Departments of Urology, University of Thrace, Alexandroupolis, Greece
    Scand J Urol Nephrol 41:362-6. 2007
    ..To elucidate the role of the eicosanoids prostaglandin E(2) (PGE(2)), 6-keto-prostaglandin F(1a) (PGF(1a)) and thromboxane B(2) (TXB(2)) in the maintenance of two-kidney, one-clip renovascular hypertension in rats...
  25. ncbi The effects of ovarian function on estrus synchronization with PGF in dairy cows
    Andres Waldmann
    Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, 62 Kreutzwaldi St, 51014 Tartu, Estonia
    Theriogenology 66:1364-74. 2006
    ..02) than in cows that successfully maintained pregnancy. Results suggest that a primary reason for low pregnancy rate in dairy cows after administration of PGF and TAI is inappropriate ovarian function prior to, or following treatment...
  26. ncbi Labor-associated regulation of prostaglandin E and F synthesis and action in the ovine amnion and cervix
    Hannah K Palliser
    Department of Physiology, Monash University, Clayton, Victoria, Australia
    J Soc Gynecol Investig 13:19-24. 2006
    ..The aim of the current study was to determine the level of expression of PG synthetic enzymes and receptors in these tissues in association with induced labor in sheep...
  27. ncbi Resynchronization of previously timed-inseminated beef heifers with progestins
    M G Colazo
    WCVM, University of Saskatchewan, Saskatoon, SK, Canada S7N 5B4
    Theriogenology 65:557-72. 2006
    ..Fertility was higher in heifers resynchronized with a once-used CIDR than with MGA...
  28. ncbi Effects of selective COX-2 and 5-LOX inhibition on prostaglandin and leukotriene synthesis in ductal pancreatic cancer in Syrian hamster
    J I Gregor
    Clinic of General, Visceral, Vascular and Thoracic Surgery, Germany
    Prostaglandins Leukot Essent Fatty Acids 73:89-97. 2005
    ..Combination of Cox-2-inhibition and 5-Lox-inhibition might be a suitable adjuvant therapy to prevent liver metastasis in human ductal pancreatic adenocarcinoma...
  29. ncbi Influence of vedaprofen (Quadrisol) on quality and freezability of stallion semen
    F Janett
    Clinic of Reproduction, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Theriogenology 64:1867-77. 2005
    ..05) effect on motility, normal sperm and sperm with nuclear vacuoles in fresh semen...
  30. ncbi [Theoretical and clinical aspects of the use of prostaglandins in glaucoma therapy]
    Joanna Wierzbowska
    Z Kliniki Okulistycznej Wojskowego Instytutu Medycznego w Warszawie
    Klin Oczna 106:352-9. 2004
    ..In the second part biochemical characteristics of prostaglandin analogues, using nowadays were presented. Their efficacy in reducing intraocular pressure and safety profile were described...
  31. ncbi Conception rate and reproductive function of dairy cows fed different fat sources
    H V Petit
    Dairy and Swine Research and Development Centre, Agriculture and Agri Food Canada, P O Box 90, Lennoxville, Que, Canada J1M 1Z3
    Theriogenology 66:1316-24. 2006
    ..1 mm) or MEG (18.3 mm). We inferred that pregnancy losses could be reduced by feeding whole flaxseed as a result of its effects on different factors such as modulation in concentration of progesterone and size of the CL...
  32. ncbi Effect of prostaglandins against alloxan-induced cytotoxicity to insulin secreting insulinoma RIN cells in vitro
    M M Sailaja Devi
    UND Life Sciences, 1083 Main Street, Walpole, MA 02081, USA
    Prostaglandins Leukot Essent Fatty Acids 71:309-18. 2004
    ..Furthermore, PGE(1) prevented DNA damage and apoptosis induced by alloxan. These results indicate that PGE(1) prevents alloxan-induced cytotoxicity to RIN cells in vitro...
  33. ncbi Effect of intrauterine infusion of Escherichia coli on hormonal patterns in gilts during the oestrous cycle
    Barbara Jana
    Division of Reproductive Endocrinology and Pathophysiology, Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, 10 747 Olsztyn, Tuwima 10, Poland
    Reprod Nutr Dev 44:37-48. 2004
    ....
  34. ncbi Induction of abortion in queens by administration of cabergoline (Galastop) solely or in combination with the PGF2alpha analogue Alfaprostol (Gabbrostim)
    Nil Erünal-Maral
    Pets and Vets Clinic, Cinnah Caddesi 40 3 Cankaya, TR 06190 Ankara, Turkey
    Theriogenology 61:1471-5. 2004
    ..Cabergoline alone was ineffective in inducing abortion at later stages of pregnancy...
  35. ncbi Mapping of the genes encoding mouse prostaglandin D, E, and F and prostacyclin receptors
    T O Ishikawa
    Banyu Tsukuba Research Institute Merck, Japan
    Genomics 32:285-8. 1996
    ..Ptgdr mapped to proximal Chr 14, Ptgfr mapped to distal Chr 3, Ptgerepl mapped to middle Chr 8, and Ptgir mapped to proximal Chr 7...
  36. pmc Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids
    T A Swierkosz
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 114:1335-42. 1995
    ..In the absence of endogenous NO, lesser amounts of exogenous NO increase the activity of COX-2. In those situations in vivo when the level of NO induction is relatively low, NO does not regulate the increased activity of COX...
  37. ncbi Angiotensin II increases leptin secretion by 3T3-L1 and human adipocytes via a prostaglandin-independent mechanism
    Suyeon Kim
    Department of Nutrition and Agricultural Experiment Station, University of Tennessee, Knoxville, TN 37996, USA
    J Nutr 132:1135-40. 2002
    ..In conclusion, although Ang II stimulates both leptin and PG secretion by adipocytes, regulation of leptin secretion by Ang II in adipocytes is not mediated by a PG-dependent mechanism...
  38. ncbi PGE1 and other prostaglandins in the treatment of intermittent claudication: a meta-analysis
    Klaus Amendt
    Diakonie Krankenhaus Mannheim, Mannheim, Germany
    Angiology 56:409-15. 2005
    ..Side effects were significantly (p < 0.001) fewer with PGE1 therapy than with other PGs (14.0% vs 30.8% of patients). In conclusion, PGE1 proved to be the most effective and best tolerated of the PGs evaluated...
  39. ncbi Changes in prostaglandin F concentration in the uterus (shell gland) of the hen oviduct in relation to oviposition and estrogen
    T Takahashi
    Department of Biological Diversity and Resources, Gifu University, Yanagido, Gifu 501 1193, Japan
    Poult Sci 83:1745-9. 2004
    ....
  40. ncbi Leptin directly controls secretory activity of human ovarian granulosa cells: possible inter-relationship with the IGF/IGFBP system
    A V Sirotkin
    Research Institute of Animal Production, Nitra, Slovakia
    Horm Res 64:198-202. 2005
    ..The aim of our in vitro studies was to understand the role of leptin and the insulin-like growth factor I/insulin-like growth factor protein (IGF/IGFBP) system in controlling human ovarian function...
  41. ncbi Prostaglandin F(2alpha) metabolite and F(2)-isoprostane excretion rates in migraine
    Johanna Helmersson
    Section of Geriatrics, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Box 609, SE 751 25 Uppsala, Sweden
    Clin Sci (Lond) 102:39-43. 2002
    ..Our results indicate, however, a lower level of oxidative stress in pre-menopausal compared with post-menopausal women...
  42. ncbi Increased urinary F(2)-isoprostanes levels in the patients with Alzheimer's disease
    Kyung Mee Kim
    Bioanalysis and Biotransformation Research Center, Korea Institute of Science and Technology, P O BOX 131, Cheongryang, Seoul 130 650, South Korea
    Brain Res Bull 64:47-51. 2004
    ..05). The PGF(2 alpha), an enzymatic product of arachidonic acid, may affect the pathogenesis of AD. In addition, urinary F(2)-isoprostanes can play an important role as a biomarker in AD...
  43. ncbi The role of oxytocin, protein kinase A, and ERK-related MAP-kinase in the control of porcine ovarian follicle functions
    A V Makarevich
    Research Institute of Animal Production, Nitra, Slovak Republic
    Exp Clin Endocrinol Diabetes 112:108-14. 2004
    ..The release of prostaglandins F (PGF) and E (PGE) were determined by RIA, PKA (alpha-cat subunit), the proliferation-associated peptide PCNA ..
  44. ncbi Localization of prostanoid receptors and cyclo-oxygenase enzymes in guinea pig and human cochlea
    Johan Stjernschantz
    Department of Neuroscience, Unit of Pharmacology, Uppsala University, SE 751 24 Uppsala, Sweden
    Hear Res 197:65-73. 2004
    ..The COX-1 enzyme seems to be constitutively expressed in the cochlea in contrast to COX-2...
  45. ncbi [Marine fungus Stilbella aciculosa as a potential producer of prostaglandins]
    T V Kafanova
    Mikrobiologiia 77:508-11. 2008
    ..This finding was confirmed by the presence of direct precursors of PG, polyunsaturated eicosapentaenoic and docosahexaenoic acids, in the culture liquid. The biomass of this fungus contained PG of group B...
  46. ncbi Prostaglandin F synthase
    Kikuko Watanabe
    Division of Applied Life Sciences, Graduate School of Integrated Sciences and Arts, University of East Asia, Shimonoseki, Yamaguchi, Japan
    Prostaglandins Other Lipid Mediat 68:401-7. 2002
    ..Here, these three pathways of PGF synthesis by these enzymes are reviewed, and the physiological roles of the enzymes are discussed...
  47. ncbi High-salt diet impairs vascular relaxation mechanisms in rat middle cerebral arteries
    Julian H Lombard
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Heart Circ Physiol 284:H1124-33. 2003
    ..These observations suggest that angiotensin II suppression with a HS diet leads to impaired relaxation of cerebral arteries in response to vasodilator stimuli acting at the cell membrane...
  48. ncbi Changes of gut barrier function during anesthesia and cardiac surgery
    E Bölke
    Department of Thoracic and Vascular Surgery, University of Ulm, Germany
    Angiology 52:477-82. 2001
    ..05). In conclusion, endotoxin seems to be the earliest trigger of the mediator cascade in acute phase response and may indicate infections in the postoperative course...
  49. ncbi Eicosanoid production, thrombogenic ratio, and serum and LDL peroxides in normo- and hypercholesterolaemic post-menopausal women consuming two oleic acid-rich diets with different content of minor components
    P Oubiña
    Departamento de Nutrición y Bromatología I Nutrición, Facultad de Farmacia, Universidad Complutense, E 28040 Madrid, Spain
    Br J Nutr 85:41-7. 2001
    ....
  50. ncbi Role of IL-6 in the pleurisy and lung injury caused by carrageenan
    S Cuzzocrea
    Institute of Pharmacology, University of Messina School of Medicine, Italy
    J Immunol 163:5094-104. 1999
    ..Taken together, our results clearly demonstrate that IL-6KO mice are more resistant to the acute inflammation of the lung caused by carrageenan injection into the pleural space than the corresponding WT mice...
  51. ncbi Long-term fenofibrate treatment impairs endothelium-dependent dilation to acetylcholine by altering the cyclooxygenase pathway
    Javier Blanco-Rivero
    Departamento de Fisiologia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo, 4, 28029 Madrid, Spain
    Cardiovasc Res 75:398-407. 2007
    ..We analyzed the effect of fenofibrate treatment on the acetylcholine-induced relaxation in rat aorta and the participation of nitric oxide (NO) and cyclooxygenase (COX)-derived factors in this effect...
  52. ncbi The efficacy of recombinant equine follicle stimulating hormone (reFSH) to promote follicular growth in mares using a follicular suppression model
    M W Jennings
    Department of Animal Science, University of California, Davis, CA 95616, USA
    Anim Reprod Sci 116:291-307. 2009
    ..Time of estrus was synchronized in 15 estrous cycling mares during the breeding season with prostaglandins F(2alpha) (PGF(2alpha)). The day after ovulation, mares were treated once daily with P&E for 14 days...
  53. ncbi Possible involvement of prostaglandins F(2alpha) and D(2) in acetylcholine-induced positive inotropy in isolated mouse left atria
    Hikaru Tanaka
    Department of Pharmacology, Toho University School of Pharmaceutical Sciences, Chiba, Japan
    Pharmacology 67:157-62. 2003
    ..These findings suggest that prostaglandins induce positive inotropic response in mouse atria through FP and EP receptor stimulation and that the former mechanism mediates in part the positive inotropic response to acetylcholine...
  54. ncbi Vasodilatory and electrophysiological actions of 8-iso-prostaglandin E2 in porcine coronary artery
    Y Zhang
    Firestone Institute for Respiratory Health, Father Sean O Sullivan Research Centre, and Department of Medicine, McMaster University, St Joseph s Healthcare, Hamilton, Ontario, L8N 4A6, Canada
    J Pharmacol Exp Ther 305:1054-60. 2003
    ..We conclude that 8-iso-prostaglandin E2 acts directly on the smooth muscle to increase K+ conductance, leading to membrane hyperpolarization and vasodilation...
  55. ncbi Equilibrium binding interactions between lotrafilcon a soft contact lenses and the two prostaglandin antiglaucoma drugs bimatoprost and tafluprost
    Richard A Kenley
    Advantar Laboratories, Inc, San Diego, CA 92121, USA
    Eye Contact Lens 39:295-302. 2013
    ....
  56. ncbi Deepening of the upper eyelid sulcus caused by 5 types of prostaglandin analogs
    Kenji Inoue
    Inouye Eye Hospital, Chiyoda ku Second Department of Ophthalmology, Toho University School of Medicine, Tokyo, Japan
    J Glaucoma 22:626-31. 2013
    ..We used 5 types of PG eye drops in Japanese subjects and examined the frequency of appearance of upper eyelid sulcus deepening in these subjects...
  57. ncbi [Receptors involved in the mechanism of action of topical prostaglandines]
    Alina Mihaela Neacsu
    Spital Judetean de Urgenta Braila
    Oftalmologia 53:3-7. 2009
    ....
  58. ncbi Effects of repeated administrations of tafluprost, latanoprost, and travoprost on optic nerve head blood flow in conscious normal rabbits
    Takahiro Akaishi
    Ophthalmic Research Group, Research and Development Center, Santen Pharmaceutical Co Ltd, 8916 16 Takayama cho, Ikoma, Nara 630 0101, Japan
    J Ocul Pharmacol Ther 26:181-6. 2010
    ..The aim of this study was to evaluate and compare the effects of repeated administrations of three prostaglandin F(2alpha) analogs (tafluprost, latanoprost, and travoprost) on optic nerve head (ONH) blood flow in normal rabbits...
  59. ncbi Influence of ShuJinHuoXue tablets on ischemia reperfusion injury of animals' skeletal muscle
    Zhihong Tong
    Hands and Feet Microsurgery, Dalian Municipal Central Hospital, Dalian 116033, China
    Molecules 17:8494-505. 2012
    ..Our results suggest that SJHXT pre-treatment may improve skeletal muscle blood vessel microcirculation, decrease skeletal muscle oxidative injury and enhance antioxidant enzymes activities in IR animals...
  60. ncbi Pharmacological modulation of postprandial colonic motor activity in the pony
    T Roger
    Department of Physiology, National Veterinary School, Toulouse, France
    J Vet Pharmacol Ther 10:273-82. 1987
    ....
  61. ncbi Arachidonic acid metabolism and casein secretion in lactating rabbit mammary epithelial cells: effects of inhibitors of prostaglandins and leukotrienes synthesis
    F Blachier
    Laboratoire de Physiologie de la Lactation INRA CRJ, Jouy en Josas, France
    Prostaglandins 35:259-76. 1988
    ..These findings show that inhibitors of AA metabolites alter casein secretion...
  62. pmc Prostaglandin D2 reduces intraocular pressure
    Y Goh
    Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan, Kyoto
    Br J Ophthalmol 72:461-4. 1988
    ..These results suggest that PGD2 or its analogues may be useful for treating glaucoma...
  63. ncbi Corneal epithelial cell viability following exposure to ophthalmic solutions containing preservatives and/or antihypertensive agents
    Jess T Whitson
    University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas, 75390 9057, USA
    Adv Ther 29:874-88. 2012
    ..This in-vitro study compared the toxicity of bimatoprost 0.01% containing benzalkonium chloride (BAK) 0.02% with other commercial BAK-free or BAK-containing prostaglandin analogs...
  64. ncbi Sympathoadrenomedullary system mediation of the prostaglandin E2-induced central inhibition of gastric acid output in rats
    K Yokotani
    Department of Pharmacology, Kochi Medical School, Japan
    J Pharmacol Exp Ther 244:335-40. 1988
    ..c.v.-administered PGs, in particular PGE2, induces a central excitation of the sympathoadrenomedullary outflow and that the resultant activation of gastric alpha adrenoceptors inhibits the vagally stimulated gastric acid output...
  65. ncbi Comparison of efficacy of four prostaglandin analogues by bilateral treatment in healthy subjects
    Ichiro Kawaguchi
    Department of Ophthalmology, Houju Memorial Hospital, Nomi, Japan
    Jpn J Ophthalmol 56:346-53. 2012
    ..To compare the drug efficacy of four prostaglandin analogues (PGAs) by bilateral treatment in normal subjects...
  66. ncbi The administration of exogenous prostaglandin may improve ovulation in pacu (Piaractus mesopotamicus)
    E Criscuolo-Urbinati
    University of Sao Paulo State Unesp, Aquaculture Centre of UNESP CAUNESP, Jaboticabal, Sao Paulo, Brazil
    Theriogenology 78:2087-94. 2012
    ..05) of previtellogenic oocytes were present in the ovaries of the PGF-treated fish. In conclusion, administration of exogenous prostaglandin may improve the outcome of hormonally induced spawning in tropical migratory fish...
  67. ncbi Prostaglandin (F and E, 2- and 3-series) production and cyclooxygenase (COX-2) gene expression of wild and cultured broodstock of Senegalese sole (Solea senegalensis)
    Fernando Norambuena
    IRTA Sant Carles de la Ràpita, Ctra Poble Nou Km 6, 43540 Sant Carles de la Rapita, Tarragona, Spain
    Gen Comp Endocrinol 177:256-62. 2012
    ....
  68. ncbi Conjunctival goblet cells density and preservative-free tafluprost therapy for glaucoma: an in vivo confocal microscopy and impression cytology study
    Leonardo Mastropasqua
    Department of Medicine and Ageing Science, Ophthalmic Clinic, University G d Annunzio of Chieti Pescara, Chieti, Italy
    Acta Ophthalmol 91:e397-405. 2013
    ..To evaluate the density of conjunctival goblet cells (GCs) in glaucomatous patients treated with preservative-free (PF) tafluprost, using laser scanning confocal microscopy (LSCM) and impression cytology (IC)...
  69. ncbi Selective cyclooxygenase inhibition improves hepatic encephalopathy in fulminant hepatic failure of rat
    Ching Chih Chang
    Division of General Medicine, Taipei Veterans General Hospital, Taiwan, ROC
    Eur J Pharmacol 666:226-32. 2011
    ..In conclusion, COX-1 inhibition by SC-560 decreases the mortalities and improves motor activities, suggesting COX-1, rather than COX-2, plays a major role in hepatic encephalopathy of FHF rats...
  70. ncbi Vasoactive peptides in the luteolytic process activated by PGF2alpha in pseudopregnant rabbits at different luteal stages
    Cristiano Boiti
    Dipartimento di Scienze Biopatologiche ed Igiene delle Produzioni Animali e Alimentari, Sezione di Fisiologia Veterinaria, Laboratorio di Biotecnologie Fisiologiche, Universita degli Studi di Perugia, I 06100 Perugia, Italy
    Biol Reprod 77:156-64. 2007
    ..These findings support the hypothesis that PGF2alpha regulates luteolysis through intraluteal activation of the renin-angiotensin/EDN1 systems in CL that have acquired luteolytic competence...
  71. ncbi [Intraocular pressure lowering effect of 0.0015% tafluprost as compared to placebo in patients with normal tension glaucoma: randomized, double-blind, multicenter, phase III study]
    Yasuaki Kuwayama
    Department of Ophthalmology, Osaka Koseinenkin Hospital, Japan
    Nihon Ganka Gakkai Zasshi 114:436-43. 2010
    ..To compare the efficacy and safety of 0.0015% tafluprost ophthalmic solution (Tafluprost) with Placebo ophthalmic solution (Placebo) in normal tension glaucoma (NTG)...
  72. ncbi In vitro toxicity of topical ocular prostaglandin analogs and preservatives on corneal epithelial cells
    Malik Y Kahook
    Department of Ophthalmology, Rocky Mountain Lions Eye Institute, University of Colorado Denver School of Medicine, Aurora, Colorado 80045, USA
    J Ocul Pharmacol Ther 26:259-63. 2010
    ..To determine the effect of 4 formulations of commercially available prostaglandin analogs (PGAs) on human corneal epithelial cells in vitro...
  73. ncbi A review of preserved and preservative-free prostaglandin analogues for the treatment of open-angle glaucoma and ocular hypertension
    A Hommer
    Augenabteilung Hera Hospital, Vienna, Austria
    Drugs Today (Barc) 46:409-16. 2010
    ..Tafluprost is a prostaglandin analogue in a preservative-free formulation that was recently approved for the reduction of elevated IOP in open-angle glaucoma and ocular hypertension...
  74. ncbi Alternative programs to presynchronize estrous cycles in dairy cattle before a timed artificial insemination program
    J S Stevenson
    Department of Animal Sciences and Industry, Kansas State University, Manhattan, KS 66506 0201, USA
    J Dairy Sci 94:205-17. 2011
    ..None of the Presynch treatments improved key responses (ovulation, luteolysis, and synchronization rate) known to improve fertility compared with a standard Cosynch program without presynchronization...
  75. ncbi Time course and attenuation of ischaemia-reperfusion induced oxidative injury by propofol in human renal transplantation
    Samar Basu
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala, Sweden
    Redox Rep 12:195-202. 2007
    ..Furthermore, propofol a well-known anaesthetic, counteracted oxidative stress by lowering the formation of a major F(2)-isoprostane...
  76. ncbi Ovarian follicular fluid eicosanoid concentrations during the pre-ovulatory period in humans
    A R Priddy
    Department of Obstetrics and Gynaecology, University Hospital of South Manchester, England
    Prostaglandins 38:197-202. 1989
    ..The significance of demonstrating leukotrienes in human follicular fluid is discussed as is the correlation between individual eicosanoids in the human ovary...
  77. ncbi Evidence for the formation of F3-isoprostanes during peroxidation of eicosapentaenoic acid
    J Nourooz-Zadeh
    Centre for Clinical Pharmacology and Therapeutic Toxicology, Department of Medicine, London, England
    Biochem Biophys Res Commun 236:467-72. 1997
    ..The possibility of analysing specific lipid peroxidation products from individual fatty acids should facilitate nutritional and biomedical studies...
  78. ncbi Role of prostaglandins in acetylcholine-induced contraction of aorta from spontaneously hypertensive and Wistar-Kyoto rats
    R M Rapoport
    Department of Pharmacology, Veterans Affairs Medical Center, University of Cincinnati, Ohio, College of Medicine 45267 0575, USA
    Hypertension 28:64-75. 1996
    ..Thus, we propose that PGI2 released in response to acetylcholine may serve as the endothelium-derived contracting factor that elicits the TxA2/PGH2 receptor-independent and dependent components of the acetylcholine-induced contraction...
  79. ncbi Novel insights into the mechanisms of pregnancy establishment: regulation of prostaglandin synthesis and signaling in the pig
    Agnieszka Waclawik
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10 747 Olsztyn, Poland
    Reproduction 142:389-99. 2011
    ..As prostaglandins F(2)(α) (PGF(2)(α)) and E(2) (PGE(2)) exert opposing actions on the CL, a tight control over their synthesis ..
  80. ncbi Opposite effect of prolactin and prostaglandin F(2 alpha) on the expression of luteal genes as revealed by rat cDNA expression array
    C Stocco
    Department of Physiology and Biophysics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois
    Endocrinology 142:4158-61. 2001
    ....
  81. pmc Interaction between head and neck squamous cell carcinoma cells and fibroblasts in the biosynthesis of PGE2
    Sonia Alcolea
    Laboratory of Angiology, Vascular Biology and Inflammation, Institute of Biomedical Research II B Sant Pau, Barcelona, Spain
    J Lipid Res 53:630-42. 2012
    ..Because mPGES-1 seems to be essential for a substantial biosynthesis of PGE(2), these findings also strengthen the concept that mPGES-1 may be \a target for therapeutic intervention in patients with HNSCC...
  82. ncbi Secretory activity of bovine ovarian granulosa cells transfected with sense and antisense insulin-like growth factor (IGF) binding protein-3 and the response to IGF-I, GH, LH, oxytocin and oestradiol
    A V Sirotkin
    Laboratory of Endocrinology, Research Institute of Animal Production, Hlohovská 949 92 Nitra, Slovak Republic
    J Mol Endocrinol 27:329-38. 2001
    ..The release of IGFBP-3, progesterone, oxytocin, IGF-I and prostaglandins F (PGF) and E (PGE) by control and transfected cells was compared...
  83. ncbi Variation in conception rates following synchronization of estrus with melengestrol acetate and prostaglandin F2 alpha
    W E Beal
    Dept of Anim Sci, Virginia Polytechnic Institute and State University, Blacksburg 24061
    J Anim Sci 66:599-602. 1988
    ..Conversely, the conception rate (66%) of treated animals fed MGA beginning earlier in the cycle was not different from that of control animals (73%; treatment x stage of cycle; P less than .05)...
  84. ncbi Endogenous prostaglandins regulate spontaneous contractile activity of uterine strips isolated from non-pregnant pigs
    Jinshan Cao
    Department of Pharmacology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido 069 8501, Japan
    Prostaglandins Other Lipid Mediat 81:93-105. 2006
    ....
  85. ncbi Efficacy and safety of tafluprost in normal-tension glaucoma with intraocular pressure of 16 mmHg or less
    Tadashi Nakano
    Department of Ophthalmology, The Jikei University School of Medicine, 3 19 18 Nishi shinbashi, Minato ku, Tokyo 105 8461, Japan
    Jpn J Ophthalmol 55:605-13. 2011
    ..To evaluate the intraocular pressure (IOP)-reducing effects and safety of 0.0015% tafluprost ophthalmic solution (tafluprost) in normal-tension glaucoma (NTG) patients with an IOP of 16 mmHg or less...
  86. ncbi Design and synthesis of 4-O-methylhonokiol analogs as inhibitors of cyclooxygenase-2 (COX-2) and PGF₁ production
    Bit Lee
    College of Pharmacy, Woosuk University, Wanju, Jeonbuk 565 701, South Korea
    Bioorg Med Chem 20:2860-8. 2012
    ..Most of all exhibited the inhibitory effects on COX-2 and PGF(1) production but not macrophage NO production. Especially, aryl carbamates 10 and 11 exhibited more potent inhibitory activity against COX-2 and PGF(1) production...
  87. ncbi Investigations into the mechanisms controlling prostaglandin production by the guinea-pig placenta: roles of calcium and gonadotrophin-releasing hormone
    H Aitken
    Division of Biomedical and Clinical Laboratory Sciences, The University of Edinburgh, Edinburgh, UK
    Prostaglandins Leukot Essent Fatty Acids 66:403-11. 2002
    ..On the sub-placenta, GnRH had an initial inhibitory action on the outputs of PGF(2alpha) and 6-keto-PGF(1 alpha), which was then followed by a stimulation of the outputs of PGF(2 alpha) and, to a lesser extent, of PGE(2)...
  88. ncbi Effect of luteinizing hormone (LH), pregnancy-specific protein B (PSPB), or arachidonic acid (AA) on secretion of progesterone and prostaglandins (PG) E (PGE; PGE(1) and PGE(2)) and F(2alpha) (PGF(2alpha)) by ovine corpora lutea of the estrous cycle or pr
    Y S Weems
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, HI 96822, USA
    Prostaglandins Other Lipid Mediat 84:163-73. 2007
    ..In addition, PSPB appears to regulate luteal secretion of progesterone from days 50 to 90 of pregnancy through stimulation of PGE secretion by ovine luteal tissue...
  89. ncbi Release of prostaglandins and leukotrienes from the rat uterus is an early estrogenic response
    O W Tawfik
    Departments of Obstetrics and Gynecology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City 66103
    Prostaglandins 34:805-15. 1987
    ..The superimposition of E2 on P4-treatment again increased the production rates of LTB4 and LTC4 at early hours, i.e. at 0.5 and 2h, respectively, as compared to P4 treatment only...
  90. ncbi Glucocorticoid-induced gastric mucosal damage: inhibition of leukotriene, but not prostaglandin biosynthesis
    J L Wallace
    Department of Physiology, Queen s University, Kingston, Ontario, Canada
    Prostaglandins 34:311-23. 1987
    ..Whether or not effects of these drugs on gastric leukotriene C4 synthesis and myeloperoxidase activity are relevant to the mechanism of ulceration is unclear...
  91. ncbi [Efficacy and tolerability of preservative-free tafluprost 0.0015 % in the treatment of glaucoma and ocular hypertension]
    M Karhanová
    Ocní klinika LF UP a FN, Olomouc Prednosta Doc MUDr Jirí Rehák
    Cesk Slov Oftalmol 68:150-5. 2012
    ..The aim of the study was to evaluate the efficacy, safety and local tolerability of preservative-free tafluprost 0.0015% (Taflotan®) in patients with glaucoma and ocular hypertension...
  92. ncbi Angiogenesis and growth factor modulation induced by alternagin C, a snake venom disintegrin-like, cysteine-rich protein on a rat skin wound model
    Estela Maria Correia Sant'Ana
    Departamento de Ciencias Fisiologicas, Universidade Federal de Sao Carlos, Rodovia Washington Luis, km 235, Sao Carlos, SP, Brazil
    Arch Biochem Biophys 479:20-7. 2008
    ..In conclusion, the present study shows for the first time the stimulation of angiogenesis in an injured tissue by a disintegrin-like protein and that ALT-C may exert this effect by modulating the expression of growth factors...
  93. ncbi Effect of removal of the endothelium on vasocontraction in canine and rabbit basilar arteries
    T Nakagomi
    Department of Neurological Surgery, University of Virginia School of Medicine, Charlottesville
    J Neurosurg 68:757-66. 1988
    ..Since endothelial damage results from subarachnoid hemorrhage, the aforementioned mechanism of vasocontraction enhancement may play a role in the pathogenesis of cerebral vasospasm...
  94. ncbi Prostaglandins f and e secretion by porcine epithelial and stromal endometrial cells on different days of the oestrous cycle
    A Blitek
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Reprod Domest Anim 39:340-6. 2004
    ..Described endometrial cells culture might serve as the model for further studies on the hormonal regulation of prostaglandin production in the pig...
  95. pmc Toxicological evaluation of preservative-containing and preservative-free topical prostaglandin analogues on a three-dimensional-reconstituted corneal epithelium system
    Hong Liang
    Department of Ophthalmology III, Quinze Vingts National Ophthalmology Hospital, Paris, France
    Br J Ophthalmol 95:869-75. 2011
    ..005% latanoprost, 0.004% travoprost, 0.03% bimatoprost containing 0.02%, 0.015% and 0.005% BAC, respectively, and the preservative-free (PF) tafluprost. Solutions of 0.01% and 0.02% BAC alone were also evaluated for comparison...
  96. ncbi Spanish multicenter tafluprost tolerability study
    Elena Milla
    Glaucoma and Genetics Unit, Institut Comtal d Oftalmologia, Via Augusta 48 54, 2n 08006 BCN Barcelona, Spain
    Br J Ophthalmol 96:826-31. 2012
    ..To evaluate the ocular surface symptoms and signs associated with preservative-free 0.0015% tafluprost in patients with glaucoma or ocular hypertension (OHT)...
  97. ncbi Cardiovascular effects of prostaglandin F(2 alpha) and prostaglandin E(2) in Atlantic cod (Gadus morhua)
    K O Stensløkken
    Division of General Physiology, Department of Biology, University of Oslo, PO Box 1051, N 0316 Oslo, Norway
    J Comp Physiol B 172:363-9. 2002
    ..Our aim was to examine the cardiovascular effect of the prostaglandins F(2 alpha) (PGF(2 alpha)) and E(2) (PGE(2)) with emphasis on branchial circulation...
  98. ncbi Drug metabolite heterogeneity in cultured single cells profiled by pico-trapping direct mass spectrometry
    Yasufumi Fukano
    Graduate School of Biomedical Sciences, Hiroshima University, 1 2 3 Kasumi, Minami Ku, Hiroshima 734 8551, Japan
    Nanomedicine (Lond) 7:1365-74. 2012
    ..We investigated the heterogeneity of tafluprost metabolism in primary human hepatocytes at a single-cell level by live single-cell mass spectrometry (MS)...
  99. ncbi Disposition and metabolism of a novel prostanoid antiglaucoma medication, tafluprost, following ocular administration to rats
    Y Fukano
    Non clinical Research Group, Research and Development Center, Santen Pharmaceutical Co Ltd, 8916 16 Takayama cho, Ikoma shi, Nara, Japan
    Drug Metab Dispos 37:1622-34. 2009
    ..The gender differences in conjugation reactions resulted in the differences in the excretion...
  100. ncbi Metabolism and ocular tissue distribution of an antiglaucoma prostanoid, tafluprost, after ocular instillation to monkeys
    Yasufumi Fukano
    Research and Development Center, Santen Pharmaceutical Co, Ltd, Ikoma shi, Nara, Japan
    J Ocul Pharmacol Ther 27:251-9. 2011
    ....
  101. ncbi Effects of cimetidine on prostanoid production in the gastric corpus specimens from rats
    K Kubota
    Department of Pharmacology, Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan
    Jpn J Pharmacol 48:491-3. 1988
    ..Cimetidine significantly stimulated the production of PGE2 in the specimens at a concentration of 10 microM, but did not significantly affect the production of PGF1 alpha and TXB2 at concentrations of 1 to 100 microM...

Research Grants2

  1. 8th World Congress for Microcirculation
    JULIAN LOMBARD; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  2. Role of ANG II in Maintaining Vascular Relaxation in Dahl S Rats
    Julian H Lombard; Fiscal Year: 2010
    ..abstract_text> ..