prostaglandins e

Summary

Summary: (11 alpha,13E,15S)-11,15-Dihydroxy-9-oxoprost-13-en-1-oic acid (PGE(1)); (5Z,11 alpha,13E,15S)-11,15-dihydroxy-9-oxoprosta-5,13-dien-1-oic acid (PGE(2)); and (5Z,11 alpha,13E,15S,17Z)-11,15-dihydroxy-9-oxoprosta-5,13,17-trien-1-oic acid (PGE(3)). Three of the six naturally occurring prostaglandins. They are considered primary in that no one is derived from another in living organisms. Originally isolated from sheep seminal fluid and vesicles, they are found in many organs and tissues and play a major role in mediating various physiological activities.

Top Publications

  1. ncbi Gonadotropin-induced expression of messenger ribonucleic acid for cyclooxygenase-2 and production of prostaglandins E and F2alpha in bovine preovulatory follicles are regulated by the progesterone receptor
    P J Bridges
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Endocrinology 147:4713-22. 2006
  2. ncbi Contribution of interaction between nitric oxide and cyclooxygenases to the production of prostaglandins in carrageenan-induced inflammation
    Masaki Toriyabe
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Anesthesiology 101:983-90. 2004
  3. ncbi Effect of luteinizing hormone (LH), pregnancy-specific protein B (PSPB), or arachidonic acid (AA) on secretion of progesterone and prostaglandins (PG) E (PGE; PGE(1) and PGE(2)) and F(2alpha) (PGF(2alpha)) by ovine corpora lutea of the estrous cycle or pr
    Y S Weems
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, HI 96822, USA
    Prostaglandins Other Lipid Mediat 84:163-73. 2007
  4. ncbi Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Stephan C Reinalter
    Department of Pediatrics, Philipps University Marburg, Deutschhausstrasse 12, D 35053 Marburg, Germany
    Kidney Int 62:253-60. 2002
  5. ncbi Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells
    Masatada Watanabe
    Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    J Endocrinol 188:59-68. 2006
  6. ncbi PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors
    Alexander V Timoshenko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Int J Cancer 108:384-9. 2004
  7. pmc Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
    Michael H Pillinger
    The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 142:973-82. 2004
  8. ncbi Regulation of cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase
    A Hurwitz
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Mt Scopus, Jerusalem, IL 91240, Israel
    Reproduction 123:663-9. 2002
  9. ncbi The effect of partial outlet obstruction on prostaglandin generation in the rabbit urinary bladder
    J M Masick
    Division of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, NY 12208, USA
    Prostaglandins Other Lipid Mediat 66:211-9. 2001
  10. ncbi Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats
    Ryo Hatazawa
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    J Pharmacol Exp Ther 318:691-9. 2006

Research Grants

  1. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
  2. Relevance of fish oil derived PGE3 to lung cancer
    Robert Newman; Fiscal Year: 2004
  3. MOLECULAR BASIS OF OXIDATIVE MODIFICATION OF LDL
    ROBERT GERD SALOMON; Fiscal Year: 2010
  4. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
  5. Prevention of Breast Cancer-Targeting COX-2 & PPARgamma
    ALAA BADAWI; Fiscal Year: 2003
  6. Air Pollution and Central Nervous System Disease
    Lilian Calderon Garciduenas; Fiscal Year: 2008
  7. Neurotoxicity of Chronic Exposure to Air Pollution
    Lilian Calderon Garciduenas; Fiscal Year: 2006
  8. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002

Detail Information

Publications224 found, 100 shown here

  1. ncbi Gonadotropin-induced expression of messenger ribonucleic acid for cyclooxygenase-2 and production of prostaglandins E and F2alpha in bovine preovulatory follicles are regulated by the progesterone receptor
    P J Bridges
    Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA
    Endocrinology 147:4713-22. 2006
    ....
  2. ncbi Contribution of interaction between nitric oxide and cyclooxygenases to the production of prostaglandins in carrageenan-induced inflammation
    Masaki Toriyabe
    Department of Anesthesiology, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo, Hokkaido 060 8543, Japan
    Anesthesiology 101:983-90. 2004
    ..This study was designed to investigate the effects of peripherally released NO on cyclooxygenase (COX) expression/activation and production of PGs in carrageenan-induced inflammation...
  3. ncbi Effect of luteinizing hormone (LH), pregnancy-specific protein B (PSPB), or arachidonic acid (AA) on secretion of progesterone and prostaglandins (PG) E (PGE; PGE(1) and PGE(2)) and F(2alpha) (PGF(2alpha)) by ovine corpora lutea of the estrous cycle or pr
    Y S Weems
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, HI 96822, USA
    Prostaglandins Other Lipid Mediat 84:163-73. 2007
    ..In addition, PSPB appears to regulate luteal secretion of progesterone from days 50 to 90 of pregnancy through stimulation of PGE secretion by ovine luteal tissue...
  4. ncbi Role of cyclooxygenase-2 in hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Stephan C Reinalter
    Department of Pediatrics, Philipps University Marburg, Deutschhausstrasse 12, D 35053 Marburg, Germany
    Kidney Int 62:253-60. 2002
    ..Using the COX-2 selective inhibitor rofecoxib, we investigated the role of COX-2 in the pathophysiology of HPS/aBS...
  5. ncbi Effect of epidermal growth factor and prostaglandin on the expression of aromatase (CYP19) in human adrenocortical carcinoma cell line NCI-H295R cells
    Masatada Watanabe
    Department of Biochemistry, Hoshi University School of Pharmacy and Pharmaceutical Sciences, 2 4 41 Ebara, Shinagawa, Tokyo 142 8501, Japan
    J Endocrinol 188:59-68. 2006
    ..These results suggest that PGE(2) secondarily acts as an autocrine signal in the up-regulation of aromatase expression by EGF in NCI-H295R cells...
  6. ncbi PGE2-mediated upregulation of iNOS in murine breast cancer cells through the activation of EP4 receptors
    Alexander V Timoshenko
    Department of Anatomy and Cell Biology, University of Western Ontario, London, Ontario, Canada
    Int J Cancer 108:384-9. 2004
    ....
  7. pmc Regulation of metalloproteinases and NF-kappaB activation in rabbit synovial fibroblasts via E prostaglandins and Erk: contrasting effects of nabumetone and 6MNA
    Michael H Pillinger
    The Department of Medicine, New York University School of Medicine, New York, NY 10016, USA
    Br J Pharmacol 142:973-82. 2004
    ..In contrast, nabumetone demonstrates anti-inflammatory and potentially arthroprotective effects that have not been previously appreciated...
  8. ncbi Regulation of cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase
    A Hurwitz
    Department of Obstetrics and Gynecology, Hadassah University Hospital, Mt Scopus, Jerusalem, IL 91240, Israel
    Reproduction 123:663-9. 2002
    ..The results from the present study indicate that iNOS-mediated NO production is involved in stimulating PGE synthesis in rat luteal cells, which may upregulate progesterone production...
  9. ncbi The effect of partial outlet obstruction on prostaglandin generation in the rabbit urinary bladder
    J M Masick
    Division of Basic and Pharmaceutical Sciences, Albany College of Pharmacy, NY 12208, USA
    Prostaglandins Other Lipid Mediat 66:211-9. 2001
    ..These data suggest obstruction of the urinary bladder induce specific elevations in PG in both smooth muscle and mucosal tissues...
  10. ncbi Roles of endogenous prostaglandins and cyclooxygenase isozymes in healing of indomethacin-induced small intestinal lesions in rats
    Ryo Hatazawa
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Kyoto 607 8414, Japan
    J Pharmacol Exp Ther 318:691-9. 2006
    ..In conclusion, endogenous PGs play a role in the healing of intestinal ulcers through EP4 receptors, yet the COX isozyme involved differs depending on the stage of healing; COX-2 in the early stage and COX-1 in the late stage...
  11. ncbi Interactions between the nitric oxide and prostaglandin E2 biosynthetic pathways in human amnion-like WISH cells
    Carla Biondi
    Department of Biology, Section of General Physiology, University of Ferrara, Via L Borsari 46, 44100 I Ferrara, Italy
    J Reprod Immunol 60:35-52. 2003
    ....
  12. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model...
  13. ncbi Effects of in vivo administration of epidermal growth factor (EGF) on uterine contractility, prostaglandin production and timing of parturition in rats
    M L Ribeiro
    Laboratorio de Fisio patología de la Preñez y el Parto, Centro de Estudios Farmacologicos y Botanicos CEFYBO, CONICET, Serrano 669, 3rd Floor, C1414DEM, Bs As Argentina
    Reproduction 126:459-68. 2003
    ..The overall effect was a delay in the onset of delivery. This in vivo effect raises the question of whether exogenous EGF plays a role in the initiation of parturition...
  14. ncbi Role of prostaglandins in the suppression of apoptosis in hen granulosa cells by transforming growth factor alpha
    R Manchanda
    Reproductive Biology Unit, Department of Obstetrics and Gynaecology, University of Ottawa, Ottawa Health Research Institute, The Ottawa Hospital (Civic Campus, Ottawa, Ontario, Canada K1Y 4E9
    Reproduction 122:91-101. 2001
    ..Whether arachidonic acid or leukotrienes are important in the anti-apoptotic action of TGF-alpha in hen granulosa cells remains to be determined...
  15. pmc Vasoconstrictor responses, and underlying mechanisms, to isoprostanes in human and porcine bronchial arterial smooth muscle
    Tracy Tazzeo
    Department of Medicine, Father Sean O Sullivan Research Centre, Firestone Institute for Respiratory Health, St Joseph s Hospital, McMaster University, 50 Charlton Avenue East L 314, Hamilton, Ontario, Canada L8N 4A6
    Br J Pharmacol 140:759-63. 2003
    ..These findings are highly relevant to lung transplantation and to exercise-induced asthma...
  16. ncbi Effect of in vivo administration of epidermal growth factor on prostaglandin production and NOS activity in term rat placentae. Possible participation of placental EGF receptors
    M L Ribeiro
    Laboratory of Physiopathology of Pregnancy and Labor, Center for Pharmacological and Botanical Studies, Serrano 669, Buenos Aires, Argentina
    Placenta 26:758-65. 2005
    ..Hence, EGF is a very interesting molecule for studying the regulation of placental prostaglandin and nitric oxide production related to the parturition process...
  17. ncbi Cloned human EP1 prostanoid receptor pharmacology characterized using radioligand binding techniques
    Najam A Sharif
    Molecular Pharmacology Unit, Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    J Pharm Pharmacol 54:539-47. 2002
    ..g. ZK118182 (K = 73.4 +/- 8.6 nM) and ZK110841 (K = 166 +/- 20 nM)). All FP (e.g. travoprost acid, fluprostenol), IP (iloprost) and TP (SQ29548) receptor-specific ligands exhibited low affinity (Ki > or = 1 microM)...
  18. ncbi Spermatozoa stimulate prostaglandin synthesis and secretion in bovine oviductal epithelial cells
    Suranga P Kodithuwakku
    Department of Animal Science, University of Peradeniya, Peradeniya 20400, Sri Lanka
    Reproduction 133:1087-94. 2007
    ..Thus, spermatozoa may bear a role in accelerating their own transport into the fertilization site...
  19. ncbi Role of prostaglandin E produced by osteoblasts in osteolysis due to bone metastasis
    Tomoyasu Ohshiba
    Department of Biochemistry, School of Pharmacy, Tokyo University of Pharmacy and Life Science, 1432 Horinouchi, Hachioji, Tokyo 192 0392, Japan
    Biochem Biophys Res Commun 300:957-64. 2003
    ..The blockage of PGE2 signal by indomethacin and EP4 antagonist abrogated the osteoclast formation induced by the breast cancer cells. Here, we show a PGE-dependent mechanism of osteolysis due to bone metastasis...
  20. ncbi What regulates placental steroidogenesis in 90-day pregnant ewes?
    Yoshie S Weems
    Department of Human Nutrition, Food, and Animal Sciences, University of Hawaii, Honolulu, HI 96822, United States
    Prostaglandins Other Lipid Mediat 84:54-65. 2007
    ..Effect of prostaglandin F(2alpha) on uterine or ovarian secretion of prostaglandins E and F(2alpha) (PGE; PGF(2alpha)) in vivo in 90-100 day hysterectomized, intact or ovariectomized pregnant ..
  21. ncbi Expression of cyclooxygenase-2 and EP4 receptor in transitional cell carcinoma of the upper urinary tract
    Yasuyoshi Miyata
    Department of Urology, Nagasaki University School of Medicine, 1 7 1 Sakamoto, Nagasaki 851 8501, Japan
    J Urol 173:56-60. 2005
    ..We determined the relationships between clinicopathological features and prognosis with expressions of COX-2 and EP4R in nonmetastatic TCC-UUT...
  22. ncbi Prostaglandin E inhibits indomethacin-induced gastric lesions through EP-1 receptors
    K Suzuki
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Kyoto, Japan
    Digestion 63:92-101. 2001
    ..CONCLUSION: PGE(2) inhibits indomethacin-induced gastric lesions, through EP(1) receptors, and this effect may be functionally associated with inhibition of gastric motility but not of neutrophil activation/migration...
  23. ncbi Antithrombin reduces ischemia/reperfusion-induced liver injury in rats by activation of cyclooxygenase-1
    Naoaki Harada
    Department of Diagnostic Medicine, Graduate School of Medical Sciences, Kumamoto University, Honjo 1 1 1 Kumamoto 860 0811, Japan
    Thromb Haemost 92:550-8. 2004
    ..Furthermore, since TNF-alpha is capable of inducing COX-2, inhibition of TNF-alpha production by AT might inhibit COX-2-mediated PGE(2) production. These effects induced by AT might contribute to its anti-inflammatory activity...
  24. ncbi Prostaglandin-endoperoxide synthase (PTGS1 and PTGS2) expression and prostaglandin production by normal monkey ovarian surface epithelium
    Rafael A Cabrera
    The Jones Institute for Reproductive Medicine, Department of Obstetrics and Gynecology, Eastern Virginia Medical School, Norfolk, Virginia, USA
    Fertil Steril 86:1088-96. 2006
    ..To determine whether hCG regulates the expression of prostaglandin (PG) synthesis enzymes and the production of PGs by normal monkey ovarian surface epithelium (OSE)...
  25. ncbi Retinol and estradiol regulation of retinol binding protein and prostaglandin production by porcine uterine epithelial cells in vitro
    P G Groothuis
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506, USA
    J Anim Sci 80:2688-94. 2002
    ..and coincident with elongation of conceptuses, retinol, retinol binding protein (RBP), estradiol (E2), and prostaglandins E (PGE) and F (PGF) increase in the uterine lumen, and RBP mRNA increases in the endometrium...
  26. ncbi Investigations into the mechanisms controlling prostaglandin production by the guinea-pig placenta: roles of calcium and gonadotrophin-releasing hormone
    H Aitken
    Division of Biomedical and Clinical Laboratory Sciences, The University of Edinburgh, Edinburgh, UK
    Prostaglandins Leukot Essent Fatty Acids 66:403-11. 2002
    ..On the sub-placenta, GnRH had an initial inhibitory action on the outputs of PGF(2alpha) and 6-keto-PGF(1 alpha), which was then followed by a stimulation of the outputs of PGF(2 alpha) and, to a lesser extent, of PGE(2)...
  27. ncbi The role of cyclooxygenases and prostanoid receptorsin furosemide-like salt losing tubulopathy: the hyperprostaglandin E syndrome
    R M Nüsing
    Department of Pediatrics, Philipp s University, Marburg, Germany
    Acta Physiol Scand 181:523-8. 2004
    ..Aspects to prostaglandin synthesis and receptor-mediated function within the kidney in patients suffering from hyperprostaglandin E syndrome/antenatal Bartter syndrome will be discussed...
  28. ncbi The influence of prostaglandins, cyclooxygenase and lipoxygenase inhibitors on collagen concentration in the rat uterine cervix
    A Bienkiewicz
    Institute of Obstetrics and Gynecology, Medical University of Lodz, Poland
    Horm Metab Res 27:79-82. 1995
    ..The results of the study suggest that cervical collagen concentration is controlled at least in part by prostaglandins and leukotrienes...
  29. ncbi Influence of vedaprofen (Quadrisol) on quality and freezability of stallion semen
    F Janett
    Clinic of Reproduction, University of Zurich, Winterthurerstrasse 260, CH 8057 Zurich, Switzerland
    Theriogenology 64:1867-77. 2005
    ..05) effect on motility, normal sperm and sperm with nuclear vacuoles in fresh semen...
  30. ncbi Prostaglandins of the E-series inhibit connective tissue proliferation in the liver wound of the rat
    A Arend
    Department of Anatomy, University of Tartu, Biomedicum, Ravila 19, 51014 Tartu, Estonia
    Ann Anat 187:57-62. 2005
    ..We believe that the rat thermic liver wound model can be used for different studies on wound healing mechanisms and that prostaglandins of the E-series are involved in wound healing in the specific time period studied...
  31. ncbi Anti-inflammatory effects of phenolic compounds isolated from the fruits of Artocarpus heterophyllus
    Song Chwan Fang
    Department of Food Nutrition, Chung Hwa University of Medical Technology, 89 Wenhwa First St, Tainan 71703, Taiwan
    J Agric Food Chem 56:4463-8. 2008
    ..Thus, artocarpesin ( 1) may provide a potential therapeutic approach for inflammation-associated disorders...
  32. ncbi Prostaglandin F synthase
    Kikuko Watanabe
    Division of Applied Life Sciences, Graduate School of Integrated Sciences and Arts, University of East Asia, Shimonoseki, Yamaguchi, Japan
    Prostaglandins Other Lipid Mediat 68:401-7. 2002
    ..Here, these three pathways of PGF synthesis by these enzymes are reviewed, and the physiological roles of the enzymes are discussed...
  33. ncbi Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, Bldg 10, Room 6N202, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:592-6. 2002
    ..Lithium and certain anticonvulsants, including carbamazepine and valproic acid, are effective antimanic drugs for treating bipolar disorder, but their mechanisms of action remain uncertain...
  34. ncbi Isolevuglandins, a novel class of isoprostenoid derivatives, function as integrated sensors of oxidant stress and are generated by myeloperoxidase in vivo
    Eugenia Poliakov
    Department of Chemistry, Case Western Reserve University, Ohio, USA
    FASEB J 17:2209-20. 2003
    ..The present studies thus identify MPO as one pathway for generation of isoLGs in vivo. They also suggest that long-lived protein isoLG adducts may serve as an alternative integrated sensor of oxidant stress in vivo...
  35. ncbi Bone-targeting macromolecular therapeutics
    Dong Wang
    Department of Pharmaceutics and Pharmaceutical Chemistry CCCD, University of Utah, Salt Lake City, UT 84112, USA
    Adv Drug Deliv Rev 57:1049-76. 2005
    ..Successful clinical application of this approach can significantly contribute to the development of treatments for many musculoskeletal diseases...
  36. ncbi Prostaglandin facilitates afferent nerve activity via EP1 receptors during urinary bladder inflammation in rats
    Makoto Ikeda
    Department of Neurophysiology, Akita University School of Medicine, Akita, Japan
    Biomed Res 27:49-54. 2006
    ..EP1 receptors in the peripheral afferent nerve terminal and/or urothelium may facilitate the primary afferent nerve activity, which elicits the inflammation-induced micturition reflex...
  37. ncbi Hypoxia-inducible factor-1alpha expression in human endometrium and its regulation by prostaglandin E-series prostanoid receptor 2 (EP2)
    Hilary O D Critchley
    University of Edinburgh, Centre for Reproductive Biology, The Queen s Medical Research Building, Scotland, UK
    Endocrinology 147:744-53. 2006
    ....
  38. ncbi Infection of human dendritic cells with herpes simplex virus type 1 dramatically diminishes the mRNA levels of the prostaglandin E(2) receptors EP2 and EP4
    Alexandros A Theodoridis
    Department of Dermatology, University Hospital Erlangen, Erlangen, Hartmannstrasse 14, 91052, Erlangen, Germany
    Immunobiology 212:827-38. 2007
    ..Additional real-time PCR and migration assays with a Deltavhs mutant virus lacking the virion host shutoff (vhs) gene implicate a vhs independent mechanism. Therefore, our results suggest a novel immune evasion strategy for HSV-1...
  39. ncbi [Regulation of prostaglandin E molecular network in mammalian reproduction]
    Li Ming Luan
    College of Life Sciences, Northeast Agricultural University, Harbin 150030
    Sheng Li Ke Xue Jin Zhan 36:209-14. 2005
    ..They compose a delicate network, which plays important roles in mammalian reproduction, especially in most processes of female reproduction...
  40. ncbi In vitro effects of eicosanoids derived from different 20-carbon fatty acids on T helper type 1 and T helper type 2 cytokine production in human whole-blood cultures
    E A Miles
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton, UK
    Clin Exp Allergy 33:624-32. 2003
    ..The effects of the different series of PGs and LTs on production of T helper type 1 (Th1) and Th2 cytokines by human cells are not well established...
  41. ncbi Tumor growth inhibition by simultaneously blocking epidermal growth factor receptor and cyclooxygenase-2 in a xenograft model
    Xin Zhang
    Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia 30322, USA
    Clin Cancer Res 11:6261-9. 2005
    ..However, an in vivo efficacy of this combined treatment in SCCHN has not been studied...
  42. ncbi Matrix metalloproteinase secretion by gastric epithelial cells is regulated by E prostaglandins and MAPKs
    Michael H Pillinger
    Department of Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 280:9973-9. 2005
    ..pylori infection and/or cyclooxygenase inhibition may induce epithelial cell signaling to contribute to gastric ulcerogenesis...
  43. ncbi PGE(2) in the regulation of programmed erythrocyte death
    P A Lang
    Department of Physiology, University of Tubingen, Germany
    Cell Death Differ 12:415-28. 2005
    ..In conclusion, hyperosmotic shock or Cl(-) removal stimulates erythrocyte PS exposure through PGE(2) formation and subsequent activation of Ca(2+)-permeable cation channels...
  44. pmc Differential regulation of prostaglandin E biosynthesis by interferon-gamma in colonic epithelial cells
    Karen L Wright
    Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath BA2 7AY
    Br J Pharmacol 141:1091-7. 2004
    ..This may have important implications for the clinical use of IFN gamma in inflammatory diseases...
  45. ncbi Inhibitory effect of a selective cyclooxygenase inhibitor on the invasion-stimulating activity of orthotopic fibroblasts for scirrhous gastric cancer cells
    Masashige Tendo
    Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Japan
    Cancer Sci 96:451-5. 2005
    ....
  46. ncbi Effect of exercise on levels of cyclo-oxygenase mediators in exhaled breath condensate in elite athletes
    J M Pucsok
    National Institute for Sports Medicine, Budapest, Hungary
    J Sports Med Phys Fitness 47:223-7. 2007
    ..The purpose of this study was to investigate the effect of symptom-limited exercise on the levels of prostaglandin E(2) (PGE2) and thromboxane B2 (TXB2) in the airways of elite sportsmen...
  47. ncbi Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor
    Shirish M Gadgeel
    Division of Hematology Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA
    Cancer 110:2775-84. 2007
    ..Therefore, it was hypothesized that tumor EGFR mutation status may influence the effectiveness of simultaneous EGFR and COX-2 inhibition in patients with NSCLC...
  48. ncbi The effect of single-dose naproxen on eicosanoid formation in human gastroduodenal mucosa
    G Treiber
    Department of Gastroenterology and Hepatology, University Hospital, Magdeburg, Germany
    Aliment Pharmacol Ther 23:155-67. 2006
    ..In animal studies, aspirin and non-aspirin non-steroidal anti-inflammatory drugs contribute to gastroduodenal damage via cyclo-oxygenase inhibition and consecutive leucotriene formation (COX-LOX eicosanoid shunt)...
  49. ncbi Efficacy and specificity of non-steroidal anti-inflammatory drugs for the inhibition of cytokine-stimulated prostaglandin E(2) secretion by amnion-derived WISH cells
    T A Sato
    Faculty of Medical and Health Sciences, Division of Pharmacology and Clinical Pharmacology, Liggins Institute, University of Auckland, Auckland, New Zealand
    Prostaglandins Leukot Essent Fatty Acids 66:525-7. 2002
    ..The results of this study suggest that PGHS-II-selective NSAIDs may be effective in the prevention of cytokine-driven amnion PG production associated with preterm labour...
  50. ncbi The impact of induced stress during days 13 and 14 of pregnancy on the composition of allantoic fluid and conceptus development in sows
    Pia Razdan
    Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, Centre for Reproductive Biology in Uppsala CRU, Swedish University of Agricultural Sciences, SLU, P O Box 7039, SE 750 07 Uppsala, Sweden
    Theriogenology 61:757-67. 2004
    ..It is, therefore, suggested that P4 influences the placenta size among food-deprived sows...
  51. ncbi Effect of mifepristone on pregnancy, pregnancy-specific protein B (PSPB), progesterone, estradiol-17beta, prostaglandin F2alpha (PGF2alpha) and prostaglandin E (PGE) in ovariectomized 90-day pregnant ewes
    Y S Weems
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu 96822, USA
    Prostaglandins Other Lipid Mediat 70:195-208. 2002
    ....
  52. pmc Evidence that 5-lipoxygenase and acetylated cyclooxygenase 2-derived eicosanoids regulate leukocyte-endothelial adherence in response to aspirin
    Stefano Fiorucci
    Clinica di Gastroenterologia ed Epatologia, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Perugia, Perugia, Italy
    Br J Pharmacol 139:1351-9. 2003
    ....
  53. ncbi Prostaglandin E1 (PGE1), but not prostaglandin E2 (PGE2), alters luteal and endometrial luteinizing hormone (LH) occupied and unoccupied LH receptors and mRNA for LH receptors in ovine luteal tissue to prevent luteolysis
    Y S Weems
    Dept of HNFAS, University of Hawaii, 1955 East West Road, Honolulu, HI 96822, USA
    Prostaglandins Other Lipid Mediat 91:42-50. 2010
    ..Instead, the embryo imparts a resistance to PGF(2)alpha. Prostaglandins E (PGE; PGE(1)+PGE(2)) are increased in endometrium and uterine venous blood during early pregnancy in ewes to ..
  54. ncbi Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults
    Ralf Schubert
    Department of Pediatrics, J W Goethe University, Frankfurt Main, Germany
    Nutrition 23:724-30. 2007
    ....
  55. pmc Dipetalodipin, a novel multifunctional salivary lipocalin that inhibits platelet aggregation, vasoconstriction, and angiogenesis through unique binding specificity for TXA2, PGF2alpha, and 15(S)-HETE
    Teresa C F Assumpção
    Vector Biology Section, Laboratory of Malaria and Vector Research, NIAID, National Institutes of Health, Bethesda, Maryland 20892 8132, USA
    J Biol Chem 285:39001-12. 2010
    ..Results suggest that DPTL blocks platelet aggregation, vasoconstriction, and angiogenesis through binding to distinct eicosanoids involved in inflammation...
  56. ncbi Natural products as a gold mine for arthritis treatment
    Dinesh Khanna
    Division of Immunology, Department of Medicine, University of Cincinnati, Cincinnati, OH, USA
    Curr Opin Pharmacol 7:344-51. 2007
    ....
  57. ncbi Expression of matrix metalloproteinases and their inhibitors in human trabecular meshwork cells
    Iok Hou Pang
    Alcon Research, Ltd, Fort Worth, Texas 76134, USA
    Invest Ophthalmol Vis Sci 44:3485-93. 2003
    ..The purpose of this study was to characterize effects of cytokines, a phorbol ester, and prostanoids on the expression of MMP-1, -2, -3, and -9 and tissue inhibitors of metalloproteinases (TIMP)-1 and -2 in cultured human TM cells...
  58. ncbi Role of prostanoids and endothelins in the prevention of cyclosporine-induced nephrotoxicity
    I E Darlametsos
    Centre Franco Hellénique de Recherches Biomédicales, Nikolaos Papanikolaou, Corporation of the Municipality Agrinion, Agrinion, 30100, Greece
    Prostaglandins Leukot Essent Fatty Acids 64:231-9. 2001
    ..All these protective agents elevated ratios of excreted renal prostanoid vasodilators (prostaglandins E(2), 6ketoF(1 alpha)) to vasoconstrictor (thromboxane B(2)), a ratio which was decreased by the administration ..
  59. ncbi Mechanisms mediating the oxygen-induced vasoreactivity of the ductus arteriosus in the chicken embryo
    Henry Greyner
    Department of Biological Science, University of North Texas, Denton, Texas 76203 5017, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1647-59. 2008
    ..b>Prostaglandins E(2), F(2alpha), and D(2) produce significant contraction of the proximal DA...
  60. ncbi Allicin and disulfiram enhance platelet integrin alphaIIbbeta3-fibrinogen binding
    Yoav Manaster
    Goldschleger Eye Research Institute and Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Israel
    Thromb Res 124:477-82. 2009
    ..The present study is aimed to support the hypothesis that prevention of specific alphaIIbbeta3 intra-molecular disulfide bond formation increases receptor-ligand binding activity...
  61. ncbi Beneficial effects of a diet rich in a mixture of n - 6/n - 3 essential fatty acids and of their metabolites on cyclosporine - nephrotoxicity
    George Tsipas
    Laboratory of Zoology, Biochemistry and Molecular Biology Department of Environmental and Natural Resources Management School of Natural Resources and Enterprises Management University of Ioannina, 301 00, Agrinio, Greece
    J Nutr Biochem 14:626-32. 2003
    ....
  62. ncbi Beneficial effects of a diet rich in a mixture of n - 6/n - 3 essential fatty acids and of their metabolites on cyclosporine - nephrotoxicity
    George Tsipas
    Laboratory of Zoology, Biochemistry and Molecular Biology Department of Environmental and Natural Resources Management School of Natural Resources and Enterprises Management University of Ioannina, 301 00, Agrinio, Greece
    J Nutr Biochem 14:480-6. 2003
    ....
  63. ncbi Resistin impairs endothelium-dependent dilation to bradykinin, but not acetylcholine, in the coronary circulation
    Gregory M Dick
    Dept of Physiology, Louisiana State University Health Sciences Center, New Orleans, USA
    Am J Physiol Heart Circ Physiol 291:H2997-3002. 2006
    ..The site of the resistin-induced impairment is unknown but may be at the bradykinin receptor or a closely associated signal transduction machinery proximal to NO synthase or cyclooxygenase...
  64. ncbi Prostaglandin E2 primes naive T cells for the production of anti-inflammatory cytokines
    C E Demeure
    Universite de Montreal, Centre de Recherche Louis Charles Simard, Hopital Notre Dame, Montreal, Canada
    Eur J Immunol 27:3526-31. 1997
    In addition to their capacity to induce pain, vasodilatation and fever, prostaglandins E (PGE) exert anti-inflammatory activities by inhibiting the release of pro-inflammatory cytokines by macrophages and T cells, and by increasing ..
  65. ncbi Amygdalin suppresses lipopolysaccharide-induced expressions of cyclooxygenase-2 and inducible nitric oxide synthase in mouse BV2 microglial cells
    Hye Young Yang
    Department of Physiology, College of Medicine, Kyung Hee University, Seoul 130 701, Korea
    Neurol Res 29:S59-64. 2007
    ..We made an aqueous extraction of amygdalin from Armeniacae semen. In this study, the effect of amygdalin on the lipopolysaccharide (LPS)-induced inflammation was investigated...
  66. ncbi Activity, synthesis, storage, and messenger RNA of cyclooxygenase in intrauterine tissues of guinea pigs near term and during labor
    J C Schellenberg
    Research Centre for Reproductive Medicine, Department of Obstetrics and Gynaecology, School of Biological Sciences, University of Auckland, New Zealand
    Prostaglandins Leukot Essent Fatty Acids 68:291-8. 2003
    ..In this study in guinea pigs, COX activity was estimated from the net production rates of prostaglandins E(2) and F(2alpha) in the presence of optimal substrate concentrations...
  67. pmc An improved LC-MS/MS method for the quantification of prostaglandins E(2) and D(2) production in biological fluids
    Hongmei Cao
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, Chicago, IL 60612, USA
    Anal Biochem 372:41-51. 2008
    ....
  68. pmc Regulation of prostaglandin production by nitric oxide; an in vivo analysis
    D Salvemini
    G D Searle, Department of Molecular Pharmacology, St Louis, MO 63167, USA
    Br J Pharmacol 114:1171-8. 1995
    ....
  69. ncbi Prostanoids as friends, not foes: further evidence from the interference by cycloxygenase-inhibitory drugs when inducing tolerance to experimental arthritigens in rats
    Michael W Whitehouse
    Therapeutics Research Unit, Department of Medicine, University of Queensland, Princess Alexandra Hospital, Woolloongabba, QLD 4102, Australia
    Inflammopharmacology 12:481-92. 2005
    ..and chronic inflammation, e.g., Lyprinol (a mussel lipid extract)...
  70. ncbi Chemical properties of bronchorrhea sputum in bronchial asthma
    S Shimura
    First Department of Internal Medicine, Tohoku University School of Medicine, Sendai, Japan
    Chest 94:1211-5. 1988
    ..sputum samples were chemically examined using ten parameters: dry weight, albumin, IgA, pH, Na+, Cl-, K+, prostaglandins E and F and histamine, and compared with eight saliva samples and 17 mucoid sputum samples...
  71. ncbi Inhibition of prostaglandin F(2alpha) by selective cyclooxygenase 2 inhibitors accounts for reduced rat leukocyte migration
    Gustavo Batista de Menezes
    Laboratório de Inflamação e Dor, Departamento de Farmacologia, Instituto de Ciencias Biologicas, Universidade Federal de Minas Gerais, Belo Horizonte 31270 901, Brazil
    Inflammation 29:163-9. 2005
    ..b>Prostaglandins E(2) and F(2alpha) were injected into the peritoneum and the chemoatractant effect was studied...
  72. ncbi Molecular mechanisms of penile erection
    Manuel Mas
    Departamento de Fisiología y Centro de Estudios Sexológicos, Universidad de La Laguna, Tenerife, Espana
    Arch Esp Urol 63:589-98. 2010
    ..cAMP) pathway activated by various intercellular messengers from neural or paracrine sources, including prostaglandins E (PGE)...
  73. ncbi Calcium-dependent diuretic system in preascitic liver cirrhosis
    G Sansoe
    Division of Gastroenterology, Gradenigo Hospital, Torino, Italy
    J Hepatol 53:856-62. 2010
    ..Ca(++) activates cell membrane calcium-sensing receptors (CaRs), leading to renal tubule production of prostaglandins E(2) (PGE(2)), which decrease both sodium reabsorption in the thick ascending limb of Henle's loop and free-..
  74. ncbi Development and validation of an on-line two-dimensional reversed-phase liquid chromatography-tandem mass spectrometry method for the simultaneous determination of prostaglandins E(2) and F(2alpha) and 13,14-dihydro-15-keto prostaglandin F(2alpha) levels
    Junji Komaba
    Pharmacokinetic Research Laboratories, Ono Pharmaceutical Co Ltd, Ibaraki, Japan
    Biomed Chromatogr 23:315-23. 2009
    ..The mean concentrations for each analyte were 0.755 pg/mL for PGE(2), 5.70 pg/mL for PGF(2alpha) and 9.48 pg/mL for F(2alpha)-M...
  75. ncbi Microvascular in vivo assessment of reperfusion injury: significance of prostaglandin E(1) and I(2) in postischemic "no-reflow" and "reflow-paradox"
    Stefan Tauber
    Institute for Surgical Research, University of Munich, D 81377 Munich, Germany
    J Surg Res 120:1-11. 2004
    ..The objectives of this study were to elucidate the impact of both prostaglandins E(1) (PGE(1)) and I(2) (PGI(2)) in microvascular reperfusion injury, with special focus on the distinct ..
  76. ncbi Expression of cyclooxygenase-2 and peroxisome proliferator-activated receptor-gamma and levels of prostaglandin E2 and 15-deoxy-delta12,14-prostaglandin J2 in human breast cancer and metastasis
    Alaa F Badawi
    Division of Population Science, Fox Chase Cancer Center, Philadelphia, PA 19111, USA
    Int J Cancer 103:84-90. 2003
    ..The purpose of our study was to examine the relationship between COX-2 (with the resulting prostaglandins E(2), PGE(2)) and PPARgamma (and its natural endogenous ligand 15-Deoxy-Delta(12,14)-prostaglandin J(2), 15d-..
  77. ncbi Cell-cell contacts trigger programmed necrosis and induce cyclooxygenase-2 expression
    J Bizik
    Haartman Institute, University of Helsinki, POB 21, FIN 00014 Helsinki, Finland
    Cell Death Differ 11:183-95. 2004
    ..Induction of COX-2 expression was accompanied by greatly enhanced production of the prostaglandins E(2), I(2), and F(2alpha)...
  78. ncbi Fluid secretion by gallbladder mucosa in experimental cholecystitis is influenced by intramural nerves
    L Jivegård
    Department of Surgery I, University of Goteborg, Sweden
    Dig Dis Sci 32:1389-94. 1987
    ..In the obstructed gallbladder, this secretion causes gallbladder distension by increasing the intraluminal pressure. This mechanism may have a key role in the pathophysiology of acute cholecystitis...
  79. ncbi Natural honey lowers plasma prostaglandin concentrations in normal individuals
    Noori S Al-Waili
    Dubai Specialized Medical Center and Medical Research Laboratories, Islamic Establishment for Education, Dubai, United Arab Emirates
    J Med Food 6:129-33. 2003
    ..At day 15, plasma concentrations of thromboxane B(2), PGE(2), and PGF(2a) were decreased by 48%, 63%, and 50%, respectively. It may be concluded that honey can lower the concentrations of prostaglandins in plasma of normal individuals...
  80. ncbi Enhanced releasability of prostaglandin E2 and leukotrienes B4 and C4 from leukocytes of patients with atopic eczema
    T Ruzicka
    Department of Dermatology, University of Munich, FRG
    Acta Derm Venereol 67:469-75. 1987
    ..Thus, our data support the hypothesis of enhanced releasability of inflammatory mediators in atopic eczema...
  81. ncbi Total dietary fat and fatty acid content modifies plasma phospholipid fatty acids, desaturase activity indices, and urinary prostaglandin E in women
    Susan K Raatz
    ARS, USDA, Human Nutrition Research Center, Grand Forks, ND 58203, USA
    Nutr Res 32:1-7. 2012
    ....
  82. pmc Identification of a novel class of anti-inflammatory compounds with anti-tumor activity in colorectal and lung cancers
    Hui Hua Chang
    Arizona Cancer Center, The University of Arizona, Tucson, AZ 85724, USA
    Invest New Drugs 30:1865-77. 2012
    ..p. of PGE0001 at 100 mg/kg decreases serum PGE(2) levels in mice within 5 h. In summary, our data suggest that the identified compound PGE0001 exerts anti-tumor activity via the inhibition of the PGE(2) synthesis pathway...
  83. ncbi 15-Deoxy-Δ(12,14)-prostaglandin J(2) interferes inducible synthesis of prostaglandins E(2) and F(2α) that suppress subsequent adipogenesis program in cultured preadipocytes
    Abu Asad Chowdhury
    Department of Life Science and Biotechnology, Shimane University, Nishikawatsu cho, Matsue, Japan
    Prostaglandins Other Lipid Mediat 95:53-62. 2011
    ..Taken together, 15d-PGJ(2) can interfere the COX pathway leading to the induced synthesis of endogenous PGs that contribute to negative regulation of adipogenesis program in preadipocytes...
  84. pmc Use of a cAMP BRET sensor to characterize a novel regulation of cAMP by the sphingosine 1-phosphate/G13 pathway
    Lily I Jiang
    Department of Pharmacology, Alliance for Cellular Signaling, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9196, USA
    J Biol Chem 282:10576-84. 2007
    ..Thus in these macrophage cells, all four major classes of G proteins can regulate intracellular cAMP...
  85. pmc Structure-function analysis of murine interleukin 1: biologically active polypeptides are at least 127 amino acids long and are derived from the carboxyl terminus of a 270-amino acid precursor
    T M DeChiara
    Proc Natl Acad Sci U S A 83:8303-7. 1986
    ..This amino-terminal end flexibility supports a processing model for IL-1 maturation that partially explains IL-1 polypeptide heterogeneity...
  86. ncbi Effects of two novel inhibitors of 5-lipoxygenase, L-651,392 and L-651,896, in a guinea-pig model of epidermal hyperproliferation
    C C Chan
    Department of Pharmacology, Merck Frosst Canada, Pointe Claire Dorval, Quebec
    Eur J Pharmacol 139:11-8. 1987
    ..It was suggested that L-651,392 and L-651,896 inhibited the ionophore-induced epidermal proliferation via their inhibitory action on the 5-lipoxygenase pathway of arachidonic acid metabolism...
  87. ncbi Isolevuglandins, oxidatively truncated phospholipids, and atherosclerosis
    Robert G Salomon
    Department of Chemistry, Case Western Reserve University, Cleveland, OH 44106 7078, USA
    Ann N Y Acad Sci 1043:327-42. 2005
    ....
  88. pmc PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42
    Olivier Boutaud
    Department of Pharmacology, Vanderbilt University, Nashville 37232 6602, Tennessee, USA
    J Neurochem 96:917-23. 2006
    ....
  89. pmc The in vitro 5-lipoxygenase and cyclo-oxygenase inhibitor L-652,343 does not inhibit 5-lipoxygenase in vivo in human skin
    R M Barr
    Institute of Dermatology, United Medical School, Guys Hospital, London
    Br J Clin Pharmacol 25:23-6. 1988
    ..This shows the importance of confirming that the action of 5-lipoxygenase inhibiting drugs in vitro occurs in vivo...
  90. ncbi The in vitro effect of a lyophilized extract of wine obtained from Jacquez grapes on human chondrocytes
    A M Panico
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Catania, V le A Doria 6, 95125 Catania, Italy
    Phytomedicine 13:522-6. 2006
    ..of JW-E on the production of key molecules released during chronic inflammatory events as nitric oxide (NO), prostaglandins E(2) (PGE(2)) and reactive oxygen species (ROS) in human chondrocytes culture, stimulated with proinflammatory ..
  91. pmc Characterization of receptors involved in the direct and indirect actions of prostaglandins E and I on the guinea-pig ileum
    R A Lawrence
    Department of Pharmacology, University of Edinburgh
    Br J Pharmacol 105:271-8. 1992
    ..7. In view of the complexity of prostanoid action on the guinea-pig ileum we feel that the preparation must be used with caution to ascertain the EPl agonist or antagonist potencies of novel compounds...
  92. ncbi Induction of cyclooxygenase-2 and invasiveness by transforming growth factor-beta(1) in immortalized mouse colonocytes expressing oncogenic Ras
    Christopher D Roman
    Department of Surgery, Vanderbilt University Medical Center, Vanderbilt Ingram Cancer Center, Nashville, TN 37232 2730, USA
    J Gastrointest Surg 6:304-9. 2002
    ..Increased COX-2 expression was correlated with increased release of prostaglandins E(2) and I(2)...
  93. ncbi Prostaglandin E(2) mediates acid-induced heartburn in healthy volunteers
    Takashi Kondo
    Division of Upper Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Hyogo, Japan
    Am J Physiol Gastrointest Liver Physiol 304:G568-73. 2013
    ..80, P = 0.029). EP1 mRNA and protein expression were observed in the normal human esophageal mucosa. Esophageal PGE(2) expression is associated with mucosal acid exposure and heartburn...
  94. ncbi Content and formation of prostaglandins and distribution of prostaglandin-related enzyme activities in the rat ocular system
    Y Goh
    Hayaishi Bioinformation Transfer Project, Research Development Corporation of Japan, Kyoto
    Biochim Biophys Acta 921:302-11. 1987
    ..5 mM). The activity of the dehydrogenase was low even in the retina, the tissue with the highest levels (0.51, 0.35 and 0.15 nmol/min per g for prostaglandin E2, F2 alpha and D2, respectively)...
  95. pmc Increased cyclooxygenase-2-derived prostanoids contributes to the hyperreactivity to noradrenaline in mesenteric resistance arteries from offspring of diabetic rats
    Fernanda E Ramos-Alves
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
    PLoS ONE 7:e50593. 2012
    ..Release of thromboxane A(2) (TxA(2)) and prostaglandins E(2) (PGE(2)) and F(2α) (PGF(2α)), was measured by specific enzyme immunoassay kits...
  96. ncbi Rhynchophylline attenuates LPS-induced pro-inflammatory responses through down-regulation of MAPK/NF-κB signaling pathways in primary microglia
    Yu Song
    Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, PR China
    Phytother Res 26:1528-33. 2012
    ..The results showed that RIN markedly reduced the production of nitric oxide (NO), prostaglandins E(2) (PGE(2) ), monocyte chemoattractant protein (MCP-1), tumor necrosis factor-α (TNF-α) and interleukin-1β ..
  97. ncbi Localization of isoketal adducts in vivo using a single-chain antibody
    Sean S Davies
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232 6602, USA
    Free Radic Biol Med 36:1163-74. 2004
    ..We conclude that isoketal adducts form in epithelial cells as a result of high oxygen exposure and that this single-chain antibody provides a valuable tool to localize the formation of isoketal adducts in tissues in vivo...
  98. pmc Inflamm-aging and arachadonic acid metabolite differences with stage of tendon disease
    Stephanie Georgina Dakin
    Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, Hatfield, United Kingdom
    PLoS ONE 7:e48978. 2012
    ..Levels of prostaglandins E(2) (PGE(2)), F(2α) (PGF(2α)), lipoxin A(4) (LXA(4)) and its receptor FPR2/ALX were analysed in extracts of ..
  99. ncbi Prostaglandin (F and E, 2- and 3-series) production and cyclooxygenase (COX-2) gene expression of wild and cultured broodstock of Senegalese sole (Solea senegalensis)
    Fernando Norambuena
    IRTA Sant Carles de la Ràpita, Ctra Poble Nou Km 6, 43540 Sant Carles de la Rapita, Tarragona, Spain
    Gen Comp Endocrinol 177:256-62. 2012
    ....
  100. ncbi Adrenal gland responses to lipopolysaccharide after stress and ethanol administration in male rats
    C E Mohn
    Centro de Estudios Farmacol gicos y Bot nicos CEFYBO CONICET UBA, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 1121ABG Buenos Aires, Argentina
    Stress 14:216-26. 2011
    ..Therefore, we conclude that moderate alcohol consumption could attenuate the effects of psychophysical stress and impair an inflammatory response...
  101. ncbi Full automation of solid-phase microextraction/on-fiber derivatization for simultaneous determination of endocrine-disrupting chemicals and steroid hormones by gas chromatography-mass spectrometry
    Lihua Yang
    State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen Zhongshan University, Guangzhou 510275, People s Republic of China
    Anal Bioanal Chem 386:391-7. 2006
    ..The developed fully automated SPME and on-fiber silylation procedures showed satisfactory applications in environmental analysis and the performances show improved precision and a reduced analysis time compared to the manual method...

Research Grants9

  1. Role of T cells and PPARgamma in Graves' orbital fibroblast adipogenesis
    Richard P Phipps; Fiscal Year: 2010
    ..This new information will permit the development of new approaches to control inflammation and the pathologic differentiation of orbital fibroblasts important for TAO and other diseases that involve fat deposition. ..
  2. Relevance of fish oil derived PGE3 to lung cancer
    Robert Newman; Fiscal Year: 2004
    ..To evaluate the relative efficacy of EPA, DHA and fish oil (containing both fatty acids) in prevention of tumor growth and its correlation to alteration of eicosanoid metabolism in a mouse model of human lung cancer. ..
  3. MOLECULAR BASIS OF OXIDATIVE MODIFICATION OF LDL
    ROBERT GERD SALOMON; Fiscal Year: 2010
    ..Our research is aimed at understanding why there is an accumulation of cholesterol in these cells because of their inability to efficiently break down the oxLDL and clear the released cholesterol. ..
  4. GENE SPECIFIC MUTATIONS IN SKIN INDUCED BY PEROXYNITRITE
    Fredika Robertson; Fiscal Year: 2001
    ..The hypothesis driving this research is that NO and peroxynitrite are mutagenic, and could be important contributors to oxidative DNA damage and mutation in human epidermal keratinocytes at sites of inflammation. ..
  5. Prevention of Breast Cancer-Targeting COX-2 & PPARgamma
    ALAA BADAWI; Fiscal Year: 2003
    ..abstract_text> ..
  6. Air Pollution and Central Nervous System Disease
    Lilian Calderon Garciduenas; Fiscal Year: 2008
    ..The Award will give me the opportunity to build new skills in 4 areas: Molecular Biology, DNA Damage, Developmental / Neurodegenerative Neuropathology, and to gain experience in grantsmanship. [unreadable] [unreadable]..
  7. Neurotoxicity of Chronic Exposure to Air Pollution
    Lilian Calderon Garciduenas; Fiscal Year: 2006
    ..abstract_text> ..
  8. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..