prostaglandins

Summary

Summary: A group of compounds derived from unsaturated 20-carbon fatty acids, primarily arachidonic acid, via the cyclooxygenase pathway. They are extremely potent mediators of a diverse group of physiological processes.

Top Publications

  1. ncbi Prostaglandins and leukotrienes: advances in eicosanoid biology
    C D Funk
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 294:1871-5. 2001
  2. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
  3. pmc Prostaglandins and inflammation
    Emanuela Ricciotti
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 31:986-1000. 2011
  4. ncbi Prostaglandins and chronic inflammation
    Tomohiro Aoki
    Department of Pharmacology, Kyoto University Graduate School of Medicine, and Core Research for Evolutional Science and Technology CREST, Kyoto 606 8501, Japan
    Trends Pharmacol Sci 33:304-11. 2012
  5. ncbi Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions
    H Jonuleit
    Department of Dermatology, University of Mainz, Germany
    Eur J Immunol 27:3135-42. 1997
  6. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
  7. ncbi Prostanoid receptors: subtypes and signaling
    R M Breyer
    Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 41:661-90. 2001
  8. ncbi International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes
    R A Coleman
    Glaxo Research and Development, Ltd, Ware, Hertfordshire, England
    Pharmacol Rev 46:205-29. 1994
  9. ncbi Activation of nuclear receptors by prostaglandins
    Tomomi Ide
    Center for Experimental Therapeutics, School of Medicine, University of Pennsylvania, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Thromb Res 110:311-5. 2003
  10. ncbi Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    Augusto C Ochoa
    Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
    Clin Cancer Res 13:721s-726s. 2007

Research Grants

  1. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
  2. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
  4. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
  5. Fatty Acids, Eicosanoids and Inflammation
    Eric K Long; Fiscal Year: 2012
  6. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
  7. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
  8. Mouse models for esophageal Cox-2 oxidative stress and DNA damage
    John P Lynch; Fiscal Year: 2013
  9. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
  10. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013

Detail Information

Publications314 found, 100 shown here

  1. ncbi Prostaglandins and leukotrienes: advances in eicosanoid biology
    C D Funk
    Center for Experimental Therapeutics and Department of Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Science 294:1871-5. 2001
    b>Prostaglandins and leukotrienes are potent eicosanoid lipid mediators derived from phospholipase-released arachidonic acid that are involved in numerous homeostatic biological functions and inflammation...
  2. ncbi Prostanoid receptors: structures, properties, and functions
    S Narumiya
    Department of Pharmacology, Kyoto University Faculty of Medicine, Kyoto, Japan
    Physiol Rev 79:1193-226. 1999
    ..In this article, we summarize these findings and attempt to give an overview of the current status of research on the prostanoid receptors...
  3. pmc Prostaglandins and inflammation
    Emanuela Ricciotti
    Institute for Translational Medicine and Therapeutics, 153 Johnson Pavilion, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Arterioscler Thromb Vasc Biol 31:986-1000. 2011
    b>Prostaglandins are lipid autacoids derived from arachidonic acid. They both sustain homeostatic functions and mediate pathogenic mechanisms, including the inflammatory response...
  4. ncbi Prostaglandins and chronic inflammation
    Tomohiro Aoki
    Department of Pharmacology, Kyoto University Graduate School of Medicine, and Core Research for Evolutional Science and Technology CREST, Kyoto 606 8501, Japan
    Trends Pharmacol Sci 33:304-11. 2012
    ..However, much has yet to be learned how inflammation becomes chronic. Prostaglandins (PGs) are well established as mediators of acute inflammation, and recent studies in experimental animals have ..
  5. ncbi Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions
    H Jonuleit
    Department of Dermatology, University of Mainz, Germany
    Eur J Immunol 27:3135-42. 1997
    ..TNF-alpha/IL-1, IL-6 + PGE2-cultured DC seem to be optimal for generation of IFN-gamma-producing CD4/CD8+ T cells...
  6. pmc Endocannabinoid hydrolysis generates brain prostaglandins that promote neuroinflammation
    Daniel K Nomura
    The Skaggs Institute for Chemical Biology and Department of Chemical Physiology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA
    Science 334:809-13. 2011
    ..are considered the primary source of arachidonic acid for cyclooxygenase (COX)-mediated biosynthesis of prostaglandins. Here, we show that a distinct pathway exists in brain, where monoacylglycerol lipase (MAGL) hydrolyzes the ..
  7. ncbi Prostanoid receptors: subtypes and signaling
    R M Breyer
    Division of Nephrology, Department of Medicine, Vanderbilt University, Nashville, Tennessee 37232, USA
    Annu Rev Pharmacol Toxicol 41:661-90. 2001
    ..The C-terminal variants modulate signal transduction, phosphorylation, and desensitization of these receptors, as well as altering agonist-independent constitutive activity...
  8. ncbi International Union of Pharmacology classification of prostanoid receptors: properties, distribution, and structure of the receptors and their subtypes
    R A Coleman
    Glaxo Research and Development, Ltd, Ware, Hertfordshire, England
    Pharmacol Rev 46:205-29. 1994
  9. ncbi Activation of nuclear receptors by prostaglandins
    Tomomi Ide
    Center for Experimental Therapeutics, School of Medicine, University of Pennsylvania, 153 Johnson Pavilion, 3620 Hamilton Walk, Philadelphia, PA 19104 6084, USA
    Thromb Res 110:311-5. 2003
    Deletion of membrane receptors for prostaglandins has revealed their importance in diverse biological systems...
  10. ncbi Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    Augusto C Ochoa
    Stanley S Scott Cancer Center and Department of Pediatrics, Louisiana State University Health Sciences Center, 533 Bolivar Street, New Orleans, LA 70112, USA
    Clin Cancer Res 13:721s-726s. 2007
    ..Preliminary data suggest that prostaglandin E(2) produced by the tumor induces arginase I expression in MDSC. Therefore, blocking MDSC activity may enhance the therapeutic efficacy of immunotherapy in RCC...
  11. ncbi Murine mast cells secrete a unique profile of cytokines and prostaglandins in response to distinct TLR2 ligands
    Salima Mrabet-Dahbi
    Allergie Centrum Charité, Department of Dermatology and Allergy, Charite Universitatsmedizin Berlin, Berlin, Germany
    Exp Dermatol 18:437-44. 2009
    ..e. tissue-residing cells, which most likely occurs during infection, can selectively raise a potent inflammatory or anti-inflammatory response, depending on TLRs which are engaged...
  12. ncbi The role of prostaglandins and other eicosanoids in the gastrointestinal tract
    Dingzhi Wang
    Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA
    Gastroenterology 128:1445-61. 2005
    ..b>Prostaglandins and other eicosanoids derived from COX-1 and COX-2 are involved in a variety of physiologic and pathologic ..
  13. ncbi Quantitative high-performance liquid chromatography/electrospray ionization tandem mass spectrometric analysis of 2- and 3-series prostaglandins in cultured tumor cells
    Peiying Yang
    Department of Experimental Therapeutics, University of Texas, M D Anderson Cancer Center, Houston 77030, USA
    Anal Biochem 308:168-77. 2002
    ..and simple technique for the simultaneous quantitative analysis of PGE(2), PGE(3), and other closely related prostaglandins from cultured cells using liquid chromatography/electrospray ionization tandem mass spectrometry...
  14. ncbi Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-derived hyperpolarizing factors, and prostaglandins
    Thomas D Giles
    Heart and Vascular Institute, Tulane University Medical Center, New Orleans, LA, USA
    J Clin Hypertens (Greenwich) 14:198-205. 2012
    ..Normal vasorelaxation is mediated by a number of endothelial systems including nitric oxide (NO), prostaglandins (PGI2 and PGE2), and a family of endothelial-derived hyperpolarizing factors (EDHF)...
  15. pmc Exosomes account for vesicle-mediated transcellular transport of activatable phospholipases and prostaglandins
    Caroline Subra
    Metabolism, Oncogenesis and Cell Differentiation Group, INSERM Research Center 563, Pathophysiology Center of Toulouse Purpan, Hopital Purpan, Toulouse, France
    J Lipid Res 51:2105-20. 2010
    ..Endosomal concentrations were in the micromolar range for prostaglandins; i.e., concentrations able to trigger prostaglandin-dependent biological responses...
  16. ncbi The role of cyclooxygenase (COX)-2 derived prostanoids on vasoconstrictor responses to phenylephrine is increased by exposure to low mercury concentration
    F M Pecanha
    Departamento de Farmacologia, Universidad Autonoma de Madrid, Madrid, Spain
    J Physiol Pharmacol 61:29-36. 2010
    ..The increased activation of the renin-angiotensin system after mercury treatment might be associated to this increased COX-2 activity...
  17. ncbi Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself?
    John L Wallace
    Inflammation Research Network, University of Calgary, Calgary, Alberta, Canada
    Physiol Rev 88:1547-65. 2008
    ..and other nonsteroidal anti-inflammatory drugs (NSAIDs), there has been great interest in the contribution of prostaglandins to gastric mucosal defense...
  18. ncbi The cyclooxygenase-2-mediated prostaglandin signaling is causally related to epithelial carcinogenesis
    Karin Muller-Decker
    Deutsches Krebsforschungszentrum Heidelberg, Eicosanoids and Tumor Development, Heidelberg, Germany
    Mol Carcinog 46:705-10. 2007
    ..Moreover, the COX-2 transgenic mouse lines are sensitized for cancer development...
  19. ncbi Cyclo-oxygenase 2: a pharmacological target for the prevention of cancer
    A J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, USA
    Lancet Oncol 2:544-51. 2001
    ..Importantly, selective COX 2 inhibitors appear to be safe enough in human beings to allow large-scale clinical testing in healthy people. Several chemoprevention trials using selective COX 2 inhibitors are underway...
  20. ncbi H2O2 increases production of constrictor prostaglandins in smooth muscle leading to enhanced arteriolar tone in Type 2 diabetic mice
    Nora Erdei
    Dept of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 292:H649-56. 2007
    ..that arteriolar tone is enhanced in Type 2 diabetes mellitus (T2-DM) due to an increased level of constrictor prostaglandins. We hypothesized that, in mice with T2-DM, hydrogen peroxide (H(2)O(2)) is involved in the increased synthesis ..
  21. ncbi VEGF-D promotes tumor metastasis by regulating prostaglandins produced by the collecting lymphatic endothelium
    Tara Karnezis
    Tumour Angiogenesis Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria 3002, Australia
    Cancer Cell 21:181-95. 2012
    ..Collecting lymphatics therefore play an active and important role in metastasis and may provide a therapeutic target to restrict tumor spread...
  22. ncbi The role of prostaglandins in human parturition
    W Gibb
    Department of Obstetrics and Gynecology, University of Ottawa, Ont, Canada
    Ann Med 30:235-41. 1998
    ..Among the various factors involved prostaglandins appear to have an important role...
  23. ncbi Cyclooxygenases, prostanoids, and tumor progression
    Man Tzu Wang
    Department of Medical Microbiology, Immunology, and Cell Biology, Southern Illinois University School of Medicine and Cancer Institute, PO Box 19626, Springfield, IL 62794 9626, USA
    Cancer Metastasis Rev 26:525-34. 2007
    ..In this review, aberrant expression and functions of several prostanoid synthetic enzymes in cancer will be discussed. The possible regulation of tumor progression by prostaglandins and their receptors will also be discussed.
  24. ncbi The effects of exogenous prostaglandins and the identification of constitutive cyclooxygenase I and II immunoreactivity in the normal guinea pig bladder
    Rik de Jongh
    Department of Urology, University Hospital Maastricht, The Netherlands
    BJU Int 100:419-29. 2007
    To establish the functional consequences of exposing the isolated whole bladder preparation to exogenous prostaglandins (PGE(1), PGE(2), PGF(2alpha)) and to determine which cells express cyclooxygenase (COX) types I and II, to generate PG ..
  25. ncbi Role of cyclopentenone prostaglandins in rat carrageenin pleurisy
    A Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    FEBS Lett 508:61-6. 2001
    ..Replacement of cyclopentenone prostaglandins by treating rats with either prostaglandin J(2) or prostaglandin D(2) reversed the exacerbating effects of ..
  26. pmc Characterization of the conditioned medium from amniotic membrane cells: prostaglandins as key effectors of its immunomodulatory activity
    Daniele Rossi
    Centro di Ricerca E Menni, Fondazione Poliambulanza Istituto Ospedaliero, Brescia, Italy
    PLoS ONE 7:e46956. 2012
    ..Only inhibition of cyclooxygenase pathway partially reverted the anti-proliferative effect, suggesting prostaglandins as key effector molecules...
  27. pmc Pathogenic yeasts Cryptococcus neoformans and Candida albicans produce immunomodulatory prostaglandins
    M C Noverr
    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109-0642, USA
    Infect Immun 69:2957-63. 2001
    ..Host cells are one source of prostaglandins; however, another potential source of prostaglandins is the fungal pathogen itself...
  28. pmc Prostaglandins in bone: bad cop, good cop?
    Katherine A Blackwell
    New England Musculoskeletal Institute, University of Connecticut Health Center, 263 Farmington Ave, Farmington, CT, USA
    Trends Endocrinol Metab 21:294-301. 2010
    b>Prostaglandins (PGs) are multifunctional regulators of bone metabolism that stimulate both bone resorption and formation...
  29. ncbi Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids
    Agostino Virdis
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hypertension 53:1008-16. 2009
    ....
  30. ncbi Novel insights into the mechanisms of pregnancy establishment: regulation of prostaglandin synthesis and signaling in the pig
    Agnieszka Waclawik
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Tuwima 10, 10 747 Olsztyn, Poland
    Reproduction 142:389-99. 2011
    ..As prostaglandins F(2)(α) (PGF(2)(α)) and E(2) (PGE(2)) exert opposing actions on the CL, a tight control over their synthesis ..
  31. ncbi Prostaglandin I2 mediates contraction and relaxation of vascular smooth muscle
    S P Williams
    Department of Pharmacology and Cell Biophysics, University of Cincinnati College of Medicine, Ohio
    Am J Physiol 267:H796-803. 1994
    ..0 and 2.3 microM, respectively. These results suggest that 1) PGI2 induces relaxation through a PGI2-PGE1 receptor, and 2) higher concentrations of PGI2 act at the TxA2-PGH2 receptor to decrease PGI2-induced relaxation...
  32. pmc Δ12-prostaglandin J3, an omega-3 fatty acid-derived metabolite, selectively ablates leukemia stem cells in mice
    Shailaja Hegde
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, 16802, USA
    Blood 118:6909-19. 2011
    ..in silico screening of public gene-expression datasets identified cyclooxygenase-derived cyclopentenone prostaglandins (CyPGs) as likely agents to target malignant stem cells...
  33. pmc Conjunctiva-associated lymphoid tissue (CALT) reactions to antiglaucoma prostaglandins with or without BAK-preservative in rabbit acute toxicity study
    Hong Liang
    INSERM, U968, Paris, France
    PLoS ONE 7:e33913. 2012
    ..IVCM-CALT analysis could be a pertinent tool in the future for understanding the immunotoxicologic challenges in the ocular surface and would provide useful criteria for evaluating newly developed eye drops...
  34. pmc Neural circuitry engaged by prostaglandins during the sickness syndrome
    Clifford B Saper
    Department of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Nat Neurosci 15:1088-95. 2012
    ..Much of the sickness syndrome is mediated by prostaglandins acting on the brain and can be prevented by nonsteroidal anti-inflammatory drugs, such as aspirin or ibuprofen,..
  35. ncbi Targeting cyclooxygenase-2 in human neoplasia: rationale and promise
    Andrew J Dannenberg
    Department of Medicine, Weill Medical College of Cornell University and Strang Cancer Prevention Center, New York, NY 10021, USA
    Cancer Cell 4:431-6. 2003
  36. ncbi Histologically normal human mammary epithelia with silenced p16(INK4a) overexpress COX-2, promoting a premalignant program
    Yongping G Crawford
    Department of Pathology and Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94143, USA
    Cancer Cell 5:263-73. 2004
    ..These putative precursors can be selectively eliminated upon exposure to COX-2 inhibitors in vitro...
  37. ncbi Requirement of cyclooxygenase-2 expression and prostaglandins for human prostate cancer cell invasion
    Kasem Nithipatikom
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Clin Exp Metastasis 19:593-601. 2002
    ..cells were used to investigate the correlation of the COX-2 expression and its arachidonic acid metabolites, prostaglandins, with their invasiveness through Matrigel using a Boyden chamber assay...
  38. ncbi Prostaglandins regulate conceptus elongation and mediate effects of interferon tau on the ovine uterine endometrium
    Piotr Dorniak
    Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A and M University, College Station, USA
    Biol Reprod 84:1119-27. 2011
    ..and the conceptus (embryo and associated extraembryonic membranes) trophectoderm synthesizes and secretes prostaglandins (PG) during early pregnancy. In mice and humans, PGs regulate endometrial function and conceptus implantation...
  39. ncbi Prostaglandins for preventing postpartum haemorrhage
    Ozge Tuncalp
    Population, Family and Reproductive Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
    Cochrane Database Syst Rev 8:CD000494. 2012
    b>Prostaglandins have mainly been used for postpartum haemorrhage (PPH) when other measures fail...
  40. ncbi Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides
    Kevin R Kozak
    Department of Biochemistry, Vanderbilt Ingram Cancer Center, and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0146, USA
    J Biol Chem 277:44877-85. 2002
    ..These results define the in vitro diversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo...
  41. pmc Non-steroidal anti-inflammatory drugs and cognitive function: are prostaglandins at the heart of cognitive impairment in dementia and delirium?
    Colm Cunningham
    School of Biochemistry and Immunology and Trinity College Institute of Neuroscience, Trinity College Dublin, Dublin, Republic of Ireland
    J Neuroimmune Pharmacol 7:60-73. 2012
    ..We will also discuss how understanding the role of inflammatory mediators in delirious episodes will have major implications for ameliorating the rate of decline in the demented population...
  42. pmc Comparison of the ocular tolerability of a latanoprost cationic emulsion versus conventional formulations of prostaglandins: an in vivo toxicity assay
    Hong Liang
    Paris Descartes University, Faculty of Biological and Pharmacological Sciences, Department of Toxicology, Paris, France
    Mol Vis 15:1690-9. 2009
    ..005% latanoprost, 0.004% travoprost, 0.03% bimatoprost (containing 0.02%, 0.015%, and 0.005% BAC, respectively), and 0.005% latanoprost in a new cationic emulsion (LCEm) formulation...
  43. ncbi Effects of limonene and essential oil from Citrus aurantium on gastric mucosa: role of prostaglandins and gastric mucus secretion
    Thiago M Moraes
    Sao Paulo State University, Department of Physiology, Rubiao Junior, CP 510, CEP 18618 000, Botucatu, Sao Paulo, Brazil
    Chem Biol Interact 180:499-505. 2009
    ..Given that LIM and OEC are excellent flavoring agents and also present gastroprotective actions, they can be regarded as a promising target for the development of a new drug for the prevention of gastric damage...
  44. ncbi Nonsteroidal anti-inflammatory drug effects on osteoblastic cell cycle, cytotoxicity, and cell death
    Je Ken Chang
    Department of Orthopaedics, School of Medicine, Orthopaedic Research Center, Kaohsiung Medical University Chug Ho Memorial Hospital, Kaohsiung, Taiwan
    Connect Tissue Res 46:200-10. 2005
    ..These results suggest that the NSAID effects on cell cycle arrest and cell death induction in osteoblasts may be one of the important mechanisms contributing to their suppressive effect on bone formation...
  45. ncbi Excitation and sensitization of nociceptors by bradykinin: what do we know?
    Kazue Mizumura
    Division of Stress Recognition and Response, Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya 464 8601, Japan
    Exp Brain Res 196:53-65. 2009
    ..In addition, TRPA1 and other ion channels appear to contribute to excitation caused by bradykinin. Finally, prostaglandins sensitize bradykinin-induced excitation in normal tissues by restoring desensitized responses due to the ..
  46. ncbi Decidualization and maintenance of a functional prostaglandin system in human endometrial cell lines following transformation with SV40 large T antigen
    Pierre Chapdelaine
    Unité de Recherche en Ontogénie et Reproduction and Unité de Recherche en Génétique Humaine, Centre de Recherche du CHUL, CHUQ, Faculte de Medecine, Universite Laval, Sainte Foy, Quebec, Canada
    Mol Hum Reprod 12:309-19. 2006
    b>Prostaglandins (PGs) are key regulators of reproductive function and associated pathologies...
  47. ncbi Punaglandins, chlorinated prostaglandins, function as potent Michael receptors to inhibit ubiquitin isopeptidase activity
    Sheryl M Verbitski
    Department of Medicinal Chemistry, University of Utah, 30 South 2000 East, Skaggs Hall, Room 307, Salt Lake City, UT 84112, USA
    J Med Chem 47:2062-70. 2004
    Cyclopentenone prostaglandins exhibit unique antineoplastic activity and are potent growth inhibitors in a variety of cultured cells...
  48. ncbi Calcitriol and genistein actions to inhibit the prostaglandin pathway: potential combination therapy to treat prostate cancer
    Srilatha Swami
    Department of Medicine, Division of Endocrinology, Stanford University School of Medicine, Stanford, CA 94305, USA
    J Nutr 137:205S-210S. 2007
    ..Both calcitriol and genistein are relatively safe and have little toxicity associated with their intake. We postulate that the combination of calcitriol and genistein is an attractive therapeutic option for the treatment of PCa...
  49. pmc Prostanoids in health and disease
    Emer M Smyth
    Institute for Translational Medicine and Therapeutics, University of Pennsylvania, PA 19104, USA
    J Lipid Res 50:S423-8. 2009
    ..This review summarizes the current knowledge on prostanoid generation and the roles of individual mediators, their biosynthetic pathways, and their receptors in health and disease...
  50. ncbi Joint pain
    Hans Georg Schaible
    Institute of Physiology 1 Neurophysiology, University Hospital Jena, Teichgraben 8, 07740 Jena, Germany
    Exp Brain Res 196:153-62. 2009
    ..of central sensitization include data on the role of excitatory amino acids, neuropeptides and spinal prostaglandins. The overview will also address long-term changes of pain-related behavior, response properties of neurons and ..
  51. ncbi Type 2 diabetic mice have increased arteriolar tone and blood pressure: enhanced release of COX-2-derived constrictor prostaglandins
    Zsolt Bagi
    Division of Physiology, New York Medical College, Valhalla, NY, USA
    Arterioscler Thromb Vasc Biol 25:1610-6. 2005
    ..We hypothesized that in T2-DM, the regulation of peripheral vascular resistance is altered because of changes in local vasomotor mechanisms...
  52. ncbi Prostanoids and their receptors that modulate dendritic cell-mediated immunity
    Norbert Gualde
    CNRS UMR 5540, University of Bordeaux 2, France
    Immunol Cell Biol 82:353-60. 2004
    ..This review summarizes the current knowledge about the role of prostanoids and their receptors in modulating DC function and the subsequent immune responses...
  53. ncbi Cyclooxygenase-2 modulates cellular growth and promotes tumorigenesis
    O C Trifan
    University of Connecticut Health Center, Center for Vascular Biology, Farmigton, CT 03032, USA
    J Cell Mol Med 7:207-22. 2003
    Cyclooxygenase (COX)-2 and the prostaglandins resulting from its enzymatic activity have been shown to play a role in modulating cell growth and development of human neoplasia...
  54. ncbi Cytokines, prostaglandins and parturition--a review
    J A Keelan
    Liggins Institute, University of Auckland, 2 6 Park Ave, Grafton, New Zealand
    Placenta 24:S33-46. 2003
    ..b>Prostaglandins, released by the membranes in response to stretch and the actions of pro-inflammatory cytokines, act not only ..
  55. ncbi Activation of the Ah receptor signaling pathway by prostaglandins
    S D Seidel
    Department of Environmental Toxicology, University of California, Davis, 95616-8588, USA
    J Biochem Mol Toxicol 15:187-96. 2001
    ..Here we have examined the ability of prostaglandins and related chemicals to activate the AhR signaling system...
  56. ncbi P2Y1 receptor-evoked glutamate exocytosis from astrocytes: control by tumor necrosis factor-alpha and prostaglandins
    Maria Domercq
    Department of Cell Biology and Morphology, University of Lausanne, Rue du Bugnon 9, 1005 Lausanne, Switzerland
    J Biol Chem 281:30684-96. 2006
    ..and is controlled by additional transductive events mediated by tumor necrosis factor-alpha (TNFalpha) and prostaglandins (PG)...
  57. ncbi Mifepristone induced progesterone withdrawal reveals novel regulatory pathways in human endometrium
    R D Catalano
    Department of Pathology, University of Cambridge, Cambridge, UK
    Mol Hum Reprod 13:641-54. 2007
    ..This greatly increases our understanding of the pathways leading to menstruation and may provide new approaches to diagnose and treat menstrual disorders...
  58. ncbi Prostaglandins and reproduction in female farm animals
    C W Weems
    Department of Human Nutrition, Food, and Animal Sciences, University of Hawaii, 1955 East West Road, Honolulu, HI 96822, USA
    Vet J 171:206-28. 2006
    b>Prostaglandins impact on ovarian, uterine, placental, and pituitary function to regulate reproduction in female livestock...
  59. pmc Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis
    Karin Muller-Decker
    Research Program Tumor Cell Regulation, Deutsches Krebsforschungszentrum, and Department of Pathology, Ruprecht Karls University, 69120 Heidelberg, Germany
    Proc Natl Acad Sci U S A 99:12483-8. 2002
    ..e., dramatically sensitizes the tissue for genotoxic carcinogens...
  60. ncbi Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation
    Aaron N Hata
    Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN, USA
    Pharmacol Ther 103:147-66. 2004
    b>Prostaglandins are lipid-derived autacoids that modulate many physiological systems including the CNS, cardiovascular, gastrointestinal, genitourinary, endocrine, respiratory, and immune systems...
  61. ncbi Cyclooxygenase-2 inhibitors in tumorigenesis (Part II)
    M M Taketo
    Laboratory of Biomedical Genetics, Graduate School of Pharmaceutical Sciences, University of Tokyo, Bunkyo, Japan
    J Natl Cancer Inst 90:1609-20. 1998
    ..These enzymes catalyze the biosynthesis of prostaglandin H2, the precursor of molecules such as prostaglandins, prostacyclin, and thromboxanes...
  62. ncbi Coupling between cyclooxygenases and terminal prostanoid synthases
    Noriko Ueno
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 338:70-6. 2005
    ..In this review, we summarize our recent understanding of the coupling profiles between the two COXs and various terminal prostanoid synthases...
  63. ncbi Risk of uterine rupture during labor among women with a prior cesarean delivery
    M Lydon-Rochelle
    Center for Women s Health Research, Department of Family and Child Nursing, School of Nursing, University of Washington, Seattle 98195 7262, USA
    N Engl J Med 345:3-8. 2001
    ..Concern persists that a trial of labor may increase the risk of uterine rupture, an uncommon but serious obstetrical complication...
  64. ncbi Prostaglandins in pathogenesis and treatment of multiple sclerosis
    Abbas Mirshafiey
    Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran 14155, Iran
    Immunopharmacol Immunotoxicol 32:543-54. 2010
    ..b>Prostaglandins (PGs) are arachidonic acid-derived autacoids that have a role in the modulation of many physiological systems ..
  65. ncbi Prostaglandins in non-insectan invertebrates: recent insights and unsolved problems
    Andrew F Rowley
    School of Biological Sciences, University of Wales Swansea, Singleton Park, Swansea SA2 8PP, UK
    J Exp Biol 208:3-14. 2005
    b>Prostaglandins (PG) are oxygenated derivatives of C20 polyunsaturated fatty acids including arachidonic and eicosapentaenoic acids...
  66. ncbi Thrombin receptors in vascular smooth muscle cells - function and regulation by vasodilatory prostaglandins
    Karsten Schror
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Universitatsstrasse 1, Gebäude 22 21, 40225 Dusseldorf, Germany
    Thromb Haemost 103:884-90. 2010
    ..Thrombin-responsive PARs are transcriptionally down-regulated in human vascular SMC by vasodilatory prostaglandins (PGI2/PGE2)...
  67. ncbi Function of COX-2 and prostaglandins in neurological disease
    X Liang
    Department of Neurology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21205, USA
    J Mol Neurosci 33:94-9. 2007
    ..Conversely, in the context of an inflammatory stimulus, the EP2 receptor enhances neuronal injury. These findings argue for an additional level of complexity in the prostaglandin response in neurological disease...
  68. ncbi Prostaglandins in health and disease: an overview
    Stephen B Miller
    Medicine, Emory University School of Medicine, Atlanta, GA 30303, USA
    Semin Arthritis Rheum 36:37-49. 2006
    b>Prostaglandins are a group of biologically active compounds that play major roles in human physiology in both health and disease. They function in many different ways and in all major organs...
  69. ncbi Anti-inflammatory drugs in the 21st century
    K D Rainsford
    Biomedical Research Centre, Faculty of Health and Wellbeing, Sheffield Hallam University, Howard Street, Sheffield, SI 1WB, UK
    Subcell Biochem 42:3-27. 2007
    ..studies that there are two cyclo-oxygenase (COX) enzyme systems controlling the production of prostanoids [prostaglandins (PGs) and thromboxane (TxA2)]; COX-1 that produces PGs and TxA2 that regulate gastrointestinal, renal, ..
  70. pmc Nitric oxide mediates prostaglandins' deleterious effect on lipopolysaccharide-triggered murine fetal resorption
    J Aisemberg
    Laboratories of Physiopathology of Pregnancy and Labor, Center for Pharmacological and Botanical Studies, National Research Council, University of Buenos Aires CEFyBO, CONICET UBA, Buenos Aires C1121ABG, Argentina
    Proc Natl Acad Sci U S A 104:7534-9. 2007
    ..We investigated the role of prostaglandins (PGs) in the mechanism of bacterial lipopolysaccharide (LPS)-induced pregnancy loss in a mouse model, and we ..
  71. ncbi Diversification of cyclooxygenase-2-derived prostaglandins in ovulation and implantation
    H Matsumoto
    Department of Molecular and Integrative Physiology, Ralph L Smith Research Center, University of Kansas Medical Center, Kansas City, Kansas 66160 7338, USA
    Biol Reprod 64:1557-65. 2001
    ..and fertilization defects in cyclooxygenase-2 (COX-2)-deficient mice suggested that COX-2-derived ovarian prostaglandins (PGs) participate in these events. However, the specific PG and its mode of action were unknown...
  72. pmc Neuroinflammation and memory: the role of prostaglandins
    Amy M Hein
    Department of Psychology and Neuroscience, University of Colorado at Boulder, Boulder, CO, USA
    Mol Neurobiol 40:15-32. 2009
    ..b>Prostaglandins (PGs), a class of lipid mediators which can have inflammatory actions, are upregulated by these inflammatory ..
  73. ncbi Prostaglandins but not leukotrienes alter extracellular matrix protein deposition and cytokine release in primary human airway smooth muscle cells and fibroblasts
    David Van Ly
    Respiratory Research Group, Cell Biology, Woolcock Institute of Medical Research, PO Box M77, Missenden Rd, Camperdown NSW 2050 Australia
    Am J Physiol Lung Cell Mol Physiol 303:L239-50. 2012
    ..Increasing evidence suggests that eicosanoids such as leukotrienes and prostaglandins (PGs) may directly mediate remodeling...
  74. ncbi Direct evidence of the cyclooxygenase pathway of prostaglandin synthesis in arthropods: genetic and biochemical characterization of two crustacean cyclooxygenases
    Külliki Varvas
    Department of Chemistry, Tallinn University of Technology, Akadeemia tee 15, 12618 Tallinn, Estonia
    Insect Biochem Mol Biol 39:851-60. 2009
    b>Prostaglandins, well-known lipid mediators in vertebrate animals, have also shown to play certain regulatory roles in insects and other arthropods acting on reproduction, immune system and ion transport...
  75. ncbi Oestrous cycle-related changes in production of Toll-like receptors and prostaglandins in the canine endometrium
    E Silva
    CIISA, Technical University of Lisbon, Lisbon, Portugal
    J Reprod Immunol 96:45-57. 2012
    ..TLRs may therefore be therapeutic targets for the control of uterine bacterial infections in the bitch and potentially in other species...
  76. pmc Exhaled leukotrienes and prostaglandins in COPD
    P Montuschi
    Department of Pharmacology, School of Medicine, Catholic University of the Sacred Heart, Rome, Italy
    Thorax 58:585-8. 2003
    The role of eicosanoids, including leukotrienes (LTs) and prostaglandins (PGs), in chronic obstructive pulmonary disease (COPD) is uncertain...
  77. ncbi Induction of dendritic cell maturation and modulation of dendritic cell-induced immune responses by prostaglandins
    K Steinbrink
    Department of Dermatology, University of Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Arch Dermatol Res 292:437-45. 2000
    ..In this study we investigated the effects of various prostaglandins (PG) on the stimulatory capacity of DC...
  78. pmc Prostaglandins antagonistically control Bax activation during apoptosis
    L Lalier
    INSERM U 892, Equipe Labellisée Ligue contre le Cancer, 8 quai Moncousu, Nantes Cedex 01, France
    Cell Death Differ 18:528-37. 2011
    ..In this study, we show that a family of bioactive lipids, namely prostaglandins, regulates Bax-dependent apoptosis...
  79. pmc Control of experimental pulmonary tuberculosis depends more on immunostimulatory leukotrienes than on the absence of immunosuppressive prostaglandins
    C Peres-Buzalaf
    Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciencias Farmaceuticas de Ribeirao Preto, Universidade de Sao Paulo, Ribeirao Preto, Sao Paulo, Brazil
    Prostaglandins Leukot Essent Fatty Acids 85:75-81. 2011
    b>Prostaglandins (PGs) and leukotrienes (LTs) are produced in Mycobacterium tuberculosis (Mtb)-infected lungs and have immune suppressive and protective effects, respectively...
  80. ncbi Aldosterone alters the participation of endothelial factors in noradrenaline vasoconstriction differently in resistance arteries from normotensive and hypertensive rats
    Fabiano E Xavier
    Departamento de Fisiologia e Farmacologia, Centro de Ciencias Biologicas, Universidade Federal de Pernambuco, Recife, Brazil
    Eur J Pharmacol 654:280-8. 2011
    ..In conclusion, chronic aldosterone treatment reduces smooth muscle contraction to alpha-adrenergic stimuli, producing a new balance in the release of endothelium-derived prostanoids and NO...
  81. pmc Update on peripheral mechanisms of pain: beyond prostaglandins and cytokines
    Hans Georg Schaible
    Institute of Physiology I Neurophysiology, Jena University Hospital Friedrich Schiller University, Teichgraben 8, D 07740 Jena, Germany
    Arthritis Res Ther 13:210. 2011
    ..identified in nociceptors that are involved in neuronal excitation and sensitization, and new targets, beyond prostaglandins and cytokines, emerged for pain therapy...
  82. ncbi Spinal prostaglandins are involved in the development but not the maintenance of inflammation-induced spinal hyperexcitability
    E Vasquez
    , , D-07740 Jena, Germany
    J Neurosci 21:9001-8. 2001
    b>Prostaglandins (PGs) are local mediators of several functions in the CNS. Both primary afferent neurons and intrinsic cells in the spinal cord produce PGs, with a marked upregulation during peripheral inflammation...
  83. ncbi Differentiation-dependent regulation of the cyclooxygenase cascade during adipogenesis suggests a complex role for prostaglandins
    Y Xie
    Department of Obstetrics and Gynecology, Laboratory of Perinatal Research, The Ohio State University, College of Medicine and Public Health, Columbus, OH 43210, USA
    Diabetes Obes Metab 8:83-93. 2006
    ..A complex role for prostaglandins (PGs) in adipogenesis is suggested...
  84. pmc Protease-activated receptors and prostaglandins in inflammatory lung disease
    Terence Peters
    School of Medicine and Pharmacology, University of Western Australia, Nedlands, Australia
    Br J Pharmacol 158:1017-33. 2009
    ..In this review, we primarily focus on the relationship between PARs, prostaglandins and inflammatory processes in the lung, and highlight their potential role in selected respiratory tract ..
  85. ncbi Beyond prostaglandins--chemistry and biology of cyclic oxygenated metabolites formed by free-radical pathways from polyunsaturated fatty acids
    Ullrich Jahn
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo namesti 2, 16610 Prague 6, Czech Republic
    Angew Chem Int Ed Engl 47:5894-955. 2008
    ..the structure of membranes to acting as precursors of physiologically important molecules, such as the prostaglandins, which for a long time were the most prominent cyclic PUFA metabolites...
  86. ncbi Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight
    Luca Parente
    Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano, Salerno, Italy
    Biochem Pharmacol 65:153-9. 2003
    The aim of this commentary is to discuss recent data on the role of prostaglandins generated by both constitutive and inducible cyclooxygenases (COXs)...
  87. ncbi Morphological and pharmacological evidence for the role of peripheral prostaglandins in the pathogenesis of neuropathic pain
    Weiya Ma
    Pain Mechanism Laboratory, Department of Anaesthesiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Eur J Neurosci 15:1037-47. 2002
    ..b>Prostaglandins (PGs) are probably included in these important inflammatory mediators...
  88. pmc Prostaglandins, bioassay and inflammation
    R J Flower
    Department of Biochemical Pharmacology, The William Harvey Research Institute, Charterhouse Square, London EC1M 6BQ
    Br J Pharmacol 147:S182-92. 2006
    ..all this changed--slowly at first and then more dramatically in the 1970s and 1980s with the emergence of the prostaglandins (PGs), the first intercellular mediators to be clearly derived from lipids, in a dynamic on-demand system...
  89. ncbi Effects of honey on the urinary total nitrite and prostaglandins concentration
    Noori S Al-Waili
    Dubai Specialized Center, Dubai and Life Support Technologies, Inc and NewTechnologies, Inc, The Mount Vernon Hospital, 7th Avenue 12 North, Mount Vernon, NY 10550, USA
    Int Urol Nephrol 37:107-11. 2005
    ..To evaluate effects of natural and artificial honey solutions on urinary nitrite content, prostaglandin excretion and urinary variables in healthy individuals...
  90. ncbi Roles of prostaglandins and leukotrienes in acute inflammation caused by bacterial infection
    Y Yoshikai
    Laboratory of Host Defense and Germfree Life, Research Institute for Disease Mechanism and Control, Nagoya University School of Medicine, Nagoya, Japan
    Curr Opin Infect Dis 14:257-63. 2001
    Prostanoids, including prostaglandins and thromboxanes, are generated by the phospholipase A2/cyclooxygenase pathway, and leukotrienes are generated by the 5-lipoxygenase pathway from arachidonic acid...
  91. ncbi Proinflammatory cytokines, prostaglandins and zinc in febrile convulsions
    S Tutuncuoglu
    Department of Pediatrics, Ege Univeristy Medical School, Izmir, Turkey
    Pediatr Int 43:235-9. 2001
    Some changes in the levels of proinflammatory cytokines, prostaglandins and zinc (Zn) in peripheral blood and cerebrospinal fluid (CSF) have been suggested to occur for the pathogenesis of febrile convulsions (FC).
  92. ncbi Regulation of TLR2 expression by prostaglandins in brain glia
    Hee Jung Yoon
    Immune and Cell Therapy Branch, National Cancer Center, Goyang, Korea
    J Immunol 180:8400-9. 2008
    ..Taken together, our results suggest that 15d-PGJ(2), 15d-PGD(2), and PGD(2) may play notable roles as modulators of the TLR2-mediated inflammatory events, and provide new insight into the resolution of inflammation in the brain...
  93. ncbi Prostaglandin receptors are mediators of vascular function in endometrial pathologies
    Henry N Jabbour
    MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, The Queen s Medical Research Institute, 47 Little France Crescent, Edinburgh EH16 4TJ, United Kingdom
    Mol Cell Endocrinol 252:191-200. 2006
    b>Prostaglandins are bioactive lipids produced from arachidonic acid by cyclooxygenase enzymes and specific terminal prostanoid synthase enzymes...
  94. pmc Proliferative action of mast-cell tryptase is mediated by PAR2, COX2, prostaglandins, and PPARgamma : Possible relevance to human fibrotic disorders
    Monica B Frungieri
    Anatomisches Institut der Universität München, Universitat Munchen, Biedersteiner Strasse 29, Germany
    Proc Natl Acad Sci U S A 99:15072-7. 2002
    ..of PAR2 leads to increased expression of cyclooxygenase 2 (COX2), a key enzyme in the biosynthesis of prostaglandins, and consequently to enhanced prostaglandin synthesis...
  95. ncbi Prostaglandins and radical oxygen species are involved in microvascular effects of hyperoxia
    A Rousseau
    Departments of Medicine and Health Sciences, Linkoping University, Linkoping, Sweden
    J Vasc Res 47:441-50. 2010
    ..Aspirin and vitamin C were used to test for involvement of prostaglandins and radical oxygen species. Forearm skin perfusion was measured using laser Doppler perfusion imaging...
  96. ncbi ATP-induced vasodilation and purinergic receptors in the human leg: roles of nitric oxide, prostaglandins, and adenosine
    Stefan P Mortensen
    The Copenhagen Muscle Research Centre, Rigshospitalet, Section 7652, Blegdamsvej 9, DK 2100 Copenhagen Ø, Denmark
    Am J Physiol Regul Integr Comp Physiol 296:R1140-8. 2009
    ..This study investigated: 1) the role of nitric oxide (NO), prostaglandins, and adenosine as mediators of ATP-induced limb vasodilation and 2) the expression and distribution of ..
  97. ncbi Yin-yang: balancing act of prostaglandins with opposing functions to regulate inflammation
    Asim K Mandal
    Section on Developmental Genetics, Heritable Disorders Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Immunol 175:6271-3. 2005
    ..We propose that while pro- and anti-inflammatory PGs counteract each other to maintain homeostasis, selective COX-2 inhibitors may disrupt this balance, thereby resulting in reported adverse effects...
  98. ncbi Cyclo-oxygenases and prostaglandins in acute inflammatory demyelination of the peripheral nerve
    Wei Hu
    Department of Neurology, Research Group for Clinical and Experimental Neuroimmunology, Heinrich Heine University, Dusseldorf, Germany
    Neurology 61:1774-9. 2003
    To investigate the expression of cyclo-oxygenases (COX), key enzymes in propagating inflammatory responses by converting arachidonic acid to prostaglandins, in inflammatory demyelinating disorders of the peripheral nervous system (PNS).
  99. ncbi Regulation of hyaluronan synthesis by vasodilatory prostaglandins. Implications for atherosclerosis
    Jens W Fischer
    Institut fur Pharmakologie und Klinische Pharmakologie, Universitatsklinikum Dusseldorf, Dusseldorf, Germany
    Thromb Haemost 98:287-95. 2007
    ..Human VSMC upregulate HAS1 and HAS2 in response to prostaglandins via Gs-coupled prostaglandin receptor subtypes IP and EP2...
  100. ncbi Ischemic preconditioning of remote organs attenuates gastric ischemia-reperfusion injury through involvement of prostaglandins and sensory nerves
    Tomasz Brzozowski
    Department of Physiology, Jagiellonian University Medical College, 16, Grzegorzecka Str, 31 531 Cracow, Poland
    Eur J Pharmacol 499:201-13. 2004
    ....
  101. ncbi Prostaglandins and sickness behavior: old story, new insights
    Emilie Pecchi
    Centre de Recherche en Neurobiologie Neurophysiologie de Marseille, UMR 6231 CNRS, USC INRA 2027, Université Paul Cézanne et Université de la Méditerranée, Marseille, France
    Physiol Behav 97:279-92. 2009
    Previous evidence has shown that prostaglandins play a key role in the development of sickness behavior observed during inflammatory states...

Research Grants73

  1. Enterococcus faecalis, Colorectal Cancer, and Bystander Effects
    Mark M Huycke; Fiscal Year: 2012
    ..These results will identify new approaches and targets for preventing sporadic colorectal cancer. ..
  2. Hydrodynamic forces modulate renal tubular function
    Rajeev Rohatgi; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Synthesis of prostaglandins (PGs), local mediators of salt and water transport in the collecting duct (CD) of the distal nephron, is regulated, in part, by extracellular fluid volume...
  3. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in physiologic and pathologic processes such as renal perfusion, gastric ..
  4. Antenatal Betamethasone in Late Preterm Gestation Lambs
    SATYANARAYANA LAKSHMINRUSIMHA; Fiscal Year: 2010
    ..of pulmonary transition at birth such as nitric oxide, beta adrenergic agents, natriuretic peptides and prostaglandins secondary to antenatal glucocorticoid use...
  5. Fatty Acids, Eicosanoids and Inflammation
    Eric K Long; Fiscal Year: 2012
    ..A key function of FABP is transport of fatty acid metabolites such as prostaglandins and leukotrienes...
  6. Flame Retardant and Adverse Perinatal Outcome (FRAPO)
    Morgan R Peltier; Fiscal Year: 2013
    ..studies suggest that treatment of placental cultures with PBDE enhances the production of cytokines and prostaglandins associated with preterm birth...
  7. VASODEPRESSOR MECHANISMS IN HYPERTENSION
    Carlos M Ferrario; Fiscal Year: 2013
    ..Understanding the regulation of this system is vital to the prevention of cardiovascular disease as well as in the design of effective therapies to reduce the consequences of the disease. ..
  8. Mouse models for esophageal Cox-2 oxidative stress and DNA damage
    John P Lynch; Fiscal Year: 2013
    ..BE is thought to be an adaptive response to chronic tissue injury and the release of pro-inflammatory prostaglandins and cytokines...
  9. ANGIOTENSINS, PROSTAGLANDINS-ADRENERGIC INTERACTIONS
    Kafait U Malik; Fiscal Year: 2013
    ....
  10. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013
    ..EETs represent the third pathway of arachidonic acid (AA) metabolism, in addition to prostaglandins and leukotrienes. Given their properties, EETs have the potential to be protective post-menopause...
  11. Neuroimmune modulation across the BBB: Regulation of ILS trafficking by TNF
    Weihong Pan; Fiscal Year: 2012
    ..We will also test the mediating effect of prostaglandins in the TNF-induced increase of the basolateral secretion of IL15...
  12. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ..via the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase (CYP) pathways producing prostaglandins (PGs), hydroperoxyeicosatetraenoic acids (HPETEs) and epoxyeicosatrienoic acids (EETs), respectively...
  13. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ....
  14. Endothelial SK3 Channel Modulation of EDHF is Estrogen Regulated
    Mike T Lin; Fiscal Year: 2011
    ..endothelium is a key regulator for many of the endothelium-derived vasoactive factors, including endothelins, prostaglandins, nitric oxide, and endothelium- derived hyperpolarizing factor (EDHF)...
  15. RESEARCH CENTER FOR PHARMACOLOGY AND DRUG TOXICOLOGY
    L Jackson Roberts; Fiscal Year: 2010
    ..Project 1 will define biochemical pathways involved in the formation of novel glyceryl-prostaglandins (PGs) from 2-arachidonylglycerol, examine their generation in cells and tissues, and characterize their ..
  16. Regulation of Neutrophilic Lung Inflammation
    John W Christman; Fiscal Year: 2013
    ..The purpose of this research is to define the basic molecular mechanisms that regulate macrophage involvement in ARDS in order to design new and effective treatments. ..
  17. FUNCTION OF THE ENTERIC NERVOUS SYSTEM
    JACKIE WOOD; Fiscal Year: 2013
    ..g., histamine, mast cell proteases and prostaglandins)...
  18. Novel mechanisms by which aspirin might protect against atherosclerosis
    Sampath Parthasarathy; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Aspirin ('acetylsalicylic acid') inhibits the formation of prostaglandins (PGs) that cause inflammation, swelling, pain and fever...
  19. The Role of Cyclooxygenase-2 in Podocyte Injury in Diabetic Nephropathy
    Raymond Harris; Fiscal Year: 2013
    ..The goal of these studies is to examine the potential role of prostaglandins as mediators and/or modulators of podocyte injury during the development of diabetic nephropathy...
  20. Unconventional Synaptic Modulation at the Vertebrate Neuromuscular Junction
    Clark A Lindgren; Fiscal Year: 2010
    ..Unconventional neuromodulators, such as nitric oxide, endocannabinoids, and prostaglandins, have been known about for many years;however, their participation in synaptic modulation at the vertebrate ..
  21. Sympathetic Nervous System and Heart Failure-Role of Primary Afferent Neurons
    Jianhua Li; Fiscal Year: 2010
    ..b>Prostaglandins and adenosine are important by-products in active muscles and engaged in the abnormal reflex response in HF...
  22. Regulation of Hepatic Uptake of Endogenous Signaling Molecules and Xenobiotics
    Ivan Csanaky; Fiscal Year: 2013
    ..bilirubin;3) gene- dosage effects of Oatp1b2 on hepatic uptake and systemic disposition of peptide hormones, prostaglandins, organic dyes, and a peptide-analog anti-diabetic drug;4) the importance of Oatp1b2 in hepatic uptake and ..
  23. Role of PGE2 and other eicosanoids in hematopoietic stem cell function
    Louis M Pelus; Fiscal Year: 2013
    ..Eicosanoids are physiological lipids that include prostaglandins, prostacyclins, thromboxanes, leukotrienes, and endocannabinoids...
  24. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..This "eicosanoid class-switch" results in the transition from inflammatory to anti-inflammatory prostaglandins and lipoxins at sites of tissue injury...
  25. Eicosanoid Balance in Lung Transplant Injury and Repair
    David Pinsky; Fiscal Year: 2009
    ..on the balance between two countervailing eicosanoid pathways of cellular injury and repair in the lungs, prostaglandins (PGs) and leukotrienes (LTs), in acute and chronic lung injury associated with transplantation...
  26. EICOSANOIDS AND VASCULAR WALL REMODELING
    Gadiparthi N Rao; Fiscal Year: 2013
    ..via the cyclooxygenase (COX), lipoxygenase (LOX) and cytochrome P450 monooxygenase (CYP) pathways producing prostaglandins (PGs), hydroperoxyeicosatetraenoic acids (HPETEs) and epoxyeicosatrienoic acids (EETs), respectively...
  27. Mechanisms of Neuroprotection in the Nucleus Tractus Solitarius of Hibernators
    BARBARA ANN HORWITZ; Fiscal Year: 2010
    ..b>Prostaglandins and adenosine are important by-products in active muscles and engaged in the abnormal reflex response in HF...
  28. Aging, Sleep Apnea, and Vascular Control During Systemic Hypoxia
    Frank A Dinenno; Fiscal Year: 2013
    ..due to age- and disease-related reductions in the local contribution of endothelium-derived nitric oxide and prostaglandins to this response, and whether acute improvements in endothelium-dependent vasodilation via ascorbic acid ..
  29. Role of inflammation in manganese neurotoxicity: molecular mechanisms
    Nikolay M Filipov; Fiscal Year: 2010
    ..results in basal ganglia pathology and enhanced production of inflammatory mediators (cytokines, nitric oxide, prostaglandins) by activated glia in vitro...
  30. Estimating Ultrasound Attenuation in Human Pregnant Cervix
    BARBARA L contact MCFARLIN; Fiscal Year: 2010
    ..In conditions where labor must be medically induced in pregnancy, pharmacological agents such as prostaglandins can accelerate the process of cervical ripening before inducing the contractions of labor...
  31. Identification and Significance of Biologic Mediators in Red Cell Concentrates
    Richard P Phipps; Fiscal Year: 2012
    ..study of 600 ICU patients will characterize the relationship of infused cell-free hemoglobin, isoprostanes, prostaglandins, and red cell storage time, with laboratory and clinical outcome measures of inflammation and hemostasis/..
  32. ACUTE AIRWAY EFFECTS OF TLR7 AND TLR8 STIMULATION IN HEALTH AND DISEASE
    David B Jacoby; Fiscal Year: 2013
    ..Our preliminary data suggest that TLR8 mediated broncho-dilation is mediated by production of prostaglandins and opening of the large conductance, calcium activated potassium channel...
  33. EICOSANOIDS AND LUNG MACROPHAGE ANTIMICROBIAL MECHANISMS
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..Lipid mediators termed eicosanoids and including leukotrienes and prostaglandins exert potent and opposing effects on the antimicrobial defense functions of the key immune cell in the lung, ..
  34. Role of Thromboxane in the Exercise Pressor Reflex in Peripheral Artery Disease
    ANNA KATHERINE LEAL; Fiscal Year: 2013
    ..It is possible that muscle metabolites, specifically prostaglandins, are partially responsible for the exaggerated cardiovascular response to exercise pressor reflex activation ..
  35. Mechanobiology of Vascular Remodeling in Pulmonary Arterial Hypertension
    LAURA ELIZABETH FREDENBURGH; Fiscal Year: 2013
    ....
  36. New Model Leading to Preterm Delivery: Role of Exposure to Environmental Toxins
    Nazeeh N Hanna; Fiscal Year: 2010
    ..There is growing recognition that cytokines and inflammatory mediators, in particular, prostaglandins, present at the maternal-fetal interface, play a fundamental role in regulating labor...
  37. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..Therefore, on the basis of these observations, the central hypothesis of my proposal is that prostaglandins produced in cerebral blood vessels through NO and CO stimulate cAMP and cGMP and produce cerebral vasodilation ..
  38. Prostaglandins in C. elegans Fertilization
    Michael A Miller; Fiscal Year: 2013
    ..b>Prostaglandins are essential for ovulation and fertilization, but the molecular mechanisms are not well understood...
  39. Lipid Tandem Quadrupole Mass Spectrometer
    ROBERT CARL MURPHY; Fiscal Year: 2010
    ..of arachidonic acid are known to play important roles in health and disease through the formation of prostaglandins and leukotrienes...
  40. MECHANICAL LOADING OF BONE AND PROSTAGLANDINS
    Carol C Pilbeam; Fiscal Year: 2010
    ..A better understanding of how mechanical loading regulates bone may help us to develop better therapies for prevention and treatment of osteoporosis. ..
  41. Autocoids in Hypertension: Pathogenesis and End Organ Damage
    Oscar A Carretero; Fiscal Year: 2013
    ..Te PPG provides integration of our efforts, collaboration, sharing of ideas and expertise, thus accelerating acquisition of knowledge on the causes of hypertension and EOD. (End of Abstract) ..
  42. Microglia and Sex Differences in the Developing Brain
    Kathryn M Lenz; Fiscal Year: 2011
    ..b>Prostaglandins are associated with proinflammatory signaling in the brain in response to injury or infection, however they ..
  43. The Role of TLR4 and RSV F Protein in Immunity to RSV
    JORGE C BLANCO; Fiscal Year: 2013
    ..It is expected that at the completion of this grant, we will have identified strategies that may lead to development of a RSV vaccine and new therapeutics for mitigating the pathologic host response to RSV. ..
  44. Eicosanoid Regulation in Atherosclerosis: Involvement of Inducible NO Synthase
    David P Hajjar; Fiscal Year: 2010
    ..b>Prostaglandins (from arachidonic acid metabolism) and nitric oxide (7NO) produced in blood vessels are critical mediators in ..
  45. Inhibiting Multiple Molecular Targets for Preventing Non-Melanoma Skin Cancer
    Mohammad Athar; Fiscal Year: 2013
    ..COX-2 expression leads to enhanced synthesis of prostaglandins (PGs), particularly PGE2 in the skin...
  46. Prostanoid signaling and inflammation in aging and Alzheimer's disease
    Katrin I Andreasson; Fiscal Year: 2013
    ..the utility of COX inhibitors, and in particular COX-2 inhibitors, is limited because production of beneficial prostaglandins may be blocked, leading to untoward side effects...
  47. Use or Metabolomic Markers of Response to Fish Oil Supplementation to Identify Ef
    CHARLES BOLT STEPHENSEN; Fiscal Year: 2011
    ..omega-3 and omega-6 fatty acid metabolites that will be measured along with an array of leukotrienes (LT), prostaglandins (PG) and thromboxanes (TX) for the study proposed here...
  48. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    ..by phospholipase A2 (PLA2), is converted to oxidized lipids collectively known as eicosanoids, including prostaglandins and leukotrienes (LT), through the cyclooxygenase (COX) and lipoxygenase (LO) pathways...
  49. Group V Phospholipase A2 and Pulmonary Inflammation
    Howard R Katz; Fiscal Year: 2012
    ..Group V sPLA2 regulates the generation of leukotrienes and prostaglandins in both mast cells and macrophages in response to stimuli that are surrogates for invading pathogens, namely ..
  50. Pathways and pathogens affecting gastric epithelial repair in vivo
    Marshall H Montrose; Fiscal Year: 2013
    ..Experiments are based on preliminary findings that show phospholipase C, protein kinase C, prostaglandins, and both intracellular and extracellular calcium mobilization are required for efficient gastric repair in ..
  51. Mechanisms of endothelial repair after vascular injury
    Zvonimir S Katusic; Fiscal Year: 2012
    ..Currently, efforts of many laboratories, including ours, are focused on understanding the mechanisms responsible for regenerative function of EPCs. The long-term goal of this application is to harness therapeutic potential of EPCs. ..
  52. Role of misoprostol in Clostridium sordellii endometritis in a rodent model
    David M Aronoff; Fiscal Year: 2012
    ..safer abortion medications, result in an increased understanding of the female reproductive tract immune system during pregnancy, and provide greater insight regarding the immunomodulatory actions of natural and synthetic prostaglandins.
  53. Secretory Phospholipase A2s in Airway Pathophysiology
    Teal S Hallstrand; Fiscal Year: 2013
    ..of enzymes that catalyze the rate-limiting step in the formation of eicosanoids such as leukotrienes (LT)s and prostaglandins (PG)s...
  54. The role of nicotinamide N-methyltransferase in glucose and lipid homeostasis
    Pavlos Pissios; Fiscal Year: 2013
    ..N1-methylnicotinamide increases the production of prostaglandins, which among other actions have profound effects on the function of adipose tissue...
  55. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    ..TLR8 in relaxation of human airway smooth muscle, B) test whether these receptors signal through nitric oxide, prostaglandins, and the large conductance, calcium activated potassium channel (BKCa) in human airways in vitro, and C) ..
  56. Prostaglandins and Cerebellum Development
    Margaret M McCarthy; Fiscal Year: 2013
    ..experiments will highlight a previously unexpected source of risk for developmental neuropsychiatric disease, prostaglandins elevated during inflammation and/or the frequently used medications designed to block inflammation...
  57. Aqueous Humor Dynamic Components that Determine Intraocular Pressure Variance
    Sayoko E Moroi; Fiscal Year: 2013
    ..conditions with treatment using the two most commonly used drug classes, beta-blockers (Aim 1) and prostaglandins (Aim 2)...
  58. Interactions of intrarenal dopamine and cyclooxygenase-2
    Raymond Harris; Fiscal Year: 2012
    PROJECT SUMMARY COX-2-derived prostaglandins from the macula densa are important modulators of renin expression and renal hemodynamics, while COX-2-derived prostaglandins in the medulla mediate natriuresis and diuresis...
  59. Prostanoids, Plasminogen Actication, and Personalized Therapeutics in IPF
    MARC L PETERS-GOLDEN; Fiscal Year: 2012
    ..These studies will identify the optimal means of harnessing the anti-fibrotic potential of these substances for future clinical trials in patients with IPF. ..
  60. Training Program in Nephrology Research
    Alfred K Cheung; Fiscal Year: 2011
    ..into those investigating: 1) collecting duct biology, involving the roles of endothelins, nitric oxide, prostaglandins, reactive oxygen species and the purinergic system in regulating collecting duct and medullary function in ..
  61. PGE2 EP1 and EP3 receptors as therapeutic targets in intracerebral hemorrhage
    Jian Wang; Fiscal Year: 2013
    ..Inflammatory mechanisms, including those mediated by certain prostaglandins (PGs), have been suggested to contribute to the progression of ICH injury...
  62. Cyclooxygenase-2 Induced Pancreatic Cancer
    Susan M Fischer; Fiscal Year: 2012
    ..COX-2 pancreata. Aim 3 will determine whether prostaglandins are driving acinar metaplasia by elevating cytokines that then recruit leukocytes...
  63. MICROVASCULAR PERMEABILITY OF THE CEREBRAL CIRCULATION
    WILLIAM MAYHAN; Fiscal Year: 1992
    ..Studies in other vascular beds suggests that pulsatile pressure and flow release prostaglandins and endothelium-derived relaxing factor (EDRF), which may modulate vascular tone...
  64. OVULATION--STUDIES USING IN VITRO PERFUSED OVARIES
    Edward Wallach; Fiscal Year: 1992
    ..Interrelationships among ovarian prostaglandins, enzymatic activity and follicle rupture will be explored in vivo and in vitro using specific plasminogen ..
  65. OMEGA-3 FATTY ACIDS AND THE CEREBRAL CIRCULATION
    EARL ELLIS; Fiscal Year: 1993
    ..Some evidence suggests that fish oils also alter formation of the vasodilator prostaglandins (PGs) E2 and I2...
  66. PROSTAGLANDINS AND LOCAL CONTROL OF THE CIRCULATION
    ALAN NIES; Fiscal Year: 1990
    The objective is to define the role of endogenously synthesized prostaglandins and other autocoids in control of the circulation and modulation of organ function...
  67. DIVALENT CATIONS AND CARDIAC LIPID METABOLISM
    MARGARET WEIS; Fiscal Year: 1990
    ..In the isolated rabbit heart, the synthesis of prostaglandins from exogenous arachidonic acid is significantly increased during perfusion with Ca2+ free buffer, while the ..
  68. PEPTIDERGIC NEURONS IN THE SPINAL CORD
    VIRGINIA SEYBOLD; Fiscal Year: 1999
    ..aim #2 continues our studies of the regulation of spinal NK1 receptors and will test the hypothesis that prostaglandins regulate NK1 receptors on spinal neurons...
  69. PROSTANOIDS IN COLON CANCER--CELL/MOLECULAR MECHANISMS
    James Roche; Fiscal Year: 1999
    ....
  70. ALDOSTERONE, RENIN AND PROSTAGLANDINS IN MAN
    Richard Horton; Fiscal Year: 1980
    This application asks for support of our ongoing research in the inter-relationships between vasodepressor prostaglandins, renin-aldosterone, renal function, and vascular reactivity in man...
  71. Combinational Chemoprevention of Esophageal Adenocarcin*
    Navtej Buttar; Fiscal Year: 2005
    ..cellular pathways including the NFKB survival pathway and cyclooxygenase-2 (COX-2) leading to high levels of prostaglandins in the esophagus...
  72. FUNCTION OF HYDROXYLASES AND OTHER OXIDATIVE
    Minor Coon; Fiscal Year: 1993
    ..evaluation of the role of this large and versatile family of cytochromes in the metabolism of steroids and prostaglandins and in the conversion of environmental chemicals either to more toxic substances, including carcinogens, or to ..
  73. MECHANISMS OF ACTIVATION OF CARDIAC NOCICEPTORS
    Hui Lin Pan; Fiscal Year: 2005
    ..Therefore, we propose to test the following novel hypotheses: 1. Myocardial interstitial prostaglandins are increased during ischemia due to stimulation of the cyclooxygenase-2 pathway, which plays a significant ..