arachidonic acid

Summary

Summary: An unsaturated, essential fatty acid. It is found in animal and human fat as well as in the liver, brain, and glandular organs, and is a constituent of animal phosphatides. It is formed by the synthesis from dietary linoleic acid and is a precursor in the biosynthesis of prostaglandins, thromboxanes, and leukotrienes.

Top Publications

  1. ncbi Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
    Hedi Harizi
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5540, Immunomodulation par les Médiateurs de l Inflammation, University of Bordeaux, 33076, France
    Trends Mol Med 14:461-9. 2008
  2. ncbi Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
    S Chyb
    Cambridge University Department of Anatomy, UK
    Nature 397:255-9. 1999
  3. ncbi Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 424:434-8. 2003
  4. ncbi Polyunsaturated fatty acids, inflammation, and immunity
    P C Calder
    Institute of Human Nutrition, University of Southampton, Southampton 5016 7PX, United Kingdom
    Lipids 36:1007-24. 2001
  5. pmc Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids
    Cosima Arnold
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Biol Chem 285:32720-33. 2010
  6. ncbi Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
    Florence Massiera
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie UMR6543CNRS, UNSA, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Lipid Res 44:271-9. 2003
  7. pmc Phospholipase A2 and arachidonic acid in Alzheimer's disease
    Rene O Sanchez-Mejia
    Scripps Clinic and the Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1801:784-90. 2010
  8. ncbi Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide
    Thad A Rosenberger
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1582, USA
    J Neurochem 88:1168-78. 2004
  9. pmc Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices
    S Fujita
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Br J Pharmacol 132:1417-22. 2001
  10. ncbi Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis
    C A C Hyde
    Department of Chemistry and Analytical Sciences, The Open University, Walton Hall, Milton Keynes, MK5 7AS, UK
    Int Immunopharmacol 9:701-15. 2009

Research Grants

  1. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
  2. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
  3. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
  4. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
  5. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
  6. Fatty Acids, Eicosanoids and Inflammation
    Eric K Long; Fiscal Year: 2012
  7. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
  8. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2012
  9. Role of lipoxygenase pathway in early microvascular dysfunction during diabetic r
    MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2013
  10. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013

Detail Information

Publications380 found, 100 shown here

  1. ncbi Arachidonic-acid-derived eicosanoids: roles in biology and immunopathology
    Hedi Harizi
    Centre National de la Recherche Scientifique, Unité Mixte de Recherche 5540, Immunomodulation par les Médiateurs de l Inflammation, University of Bordeaux, 33076, France
    Trends Mol Med 14:461-9. 2008
    b>Arachidonic acid (AA)-derived eicosanoids belong to a complex family of lipid mediators that regulate a wide variety of physiological responses and pathological processes...
  2. ncbi Polyunsaturated fatty acids activate the Drosophila light-sensitive channels TRP and TRPL
    S Chyb
    Cambridge University Department of Anatomy, UK
    Nature 397:255-9. 1999
    ..PLC also generates diacylglycerol, a potential precursor for several polyunsaturated fatty acids, such as arachidonic acid and linolenic acid...
  3. ncbi Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
    Hiroyuki Watanabe
    Department of Physiology, Campus Gasthuisberg, KU Leuven, B 3000 Leuven, Belgium
    Nature 424:434-8. 2003
    ..Here we show that the endocannabinoid anandamide and its metabolite arachidonic acid activate TRPV4 in an indirect way involving the cytochrome P450 epoxygenase-dependent formation of ..
  4. ncbi Polyunsaturated fatty acids, inflammation, and immunity
    P C Calder
    Institute of Human Nutrition, University of Southampton, Southampton 5016 7PX, United Kingdom
    Lipids 36:1007-24. 2001
    ..The n-6 PUFA arachidonic acid (AA) is the precursor of prostaglandins, leukotrienes, and related compounds, which have important roles in ..
  5. pmc Arachidonic acid-metabolizing cytochrome P450 enzymes are targets of {omega}-3 fatty acids
    Cosima Arnold
    Max Delbrueck Center for Molecular Medicine, 13125 Berlin, Germany
    J Biol Chem 285:32720-33. 2010
    ..We tested the hypothesis that EPA and DHA may compete with arachidonic acid (AA) for the conversion by cytochrome P450 (CYP) enzymes, resulting in the formation of alternative, ..
  6. ncbi Arachidonic acid and prostacyclin signaling promote adipose tissue development: a human health concern?
    Florence Massiera
    Institut de Recherche Signalisation, Biologie du Developpement et Cancer, Centre de Biochimie UMR6543CNRS, UNSA, Faculte des Sciences, Parc Valrose, 06108 Nice Cedex 2, France
    J Lipid Res 44:271-9. 2003
    ..agonists to both receptors or to saturated, monounsaturated, and omega-3 polyunsaturated fatty acids, arachidonic acid (C20:4, omega-6) promoted substantially the differentiation of clonal preadipocytes...
  7. pmc Phospholipase A2 and arachidonic acid in Alzheimer's disease
    Rene O Sanchez-Mejia
    Scripps Clinic and the Scripps Research Institute, La Jolla, CA 92037, USA
    Biochim Biophys Acta 1801:784-90. 2010
    ..Technical advances are allowing for the dissection of complex lipid pathways in normal and diseased states. Arachidonic acid (AA) and specific isoforms of phospholipase A(2) (PLA(2)) appear to be critical mediators in amyloid-beta (..
  8. ncbi Rat brain arachidonic acid metabolism is increased by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide
    Thad A Rosenberger
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892 1582, USA
    J Neurochem 88:1168-78. 2004
    ..LPS infusion also increased rates of incorporation and turnover of arachidonic acid in phosphatidylethanolamine, plasmenylethanolamine, phosphatidylcholine, and plasmenylcholine by 1.5- to 2...
  9. pmc Docosahexaenoic acid improves long-term potentiation attenuated by phospholipase A(2) inhibitor in rat hippocampal slices
    S Fujita
    Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan
    Br J Pharmacol 132:1417-22. 2001
    ..3. We then investigated the effect of docosahexaenoic acid (DHA) and arachidonic acid (AA) on BEL (bromoenol lactone, an iPLA(2)-inhibitor) -impaired LTP, and found that either DHA or AA ..
  10. ncbi Inhibition of arachidonic acid metabolism and its implication on cell proliferation and tumour-angiogenesis
    C A C Hyde
    Department of Chemistry and Analytical Sciences, The Open University, Walton Hall, Milton Keynes, MK5 7AS, UK
    Int Immunopharmacol 9:701-15. 2009
    b>Arachidonic acid (AA) and its metabolites have recently generated a heightened interest due to growing evidence of their significant role in cancer biology...
  11. ncbi Biomarkers of fat and fatty acid intake
    Lenore Arab
    University of North Carolina School of Public Health, Chapel Hill, NC 27955, USA
    J Nutr 133:925S-932S. 2003
    ..e., alcohol consumption and smoking), circulating apolipoprotein levels and the hormonal milieu of the individual and the source tissue...
  12. ncbi Association of adipose tissue arachidonic acid content with BMI and overweight status in children from Cyprus and Crete
    Savvas C Savva
    Research and Education Foundation of Child Health, Cyprus
    Br J Nutr 91:643-9. 2004
    ..The variance of BMI was better explained (38.2 %) by adipose tissue arachidonic acid content than any other n-3 and n-6 fatty acids...
  13. pmc Arachidonic acid and the brain
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    J Nutr 138:2515-20. 2008
    Kinetic methods in unanesthetized rodents have shown that turnover rates of arachidonic acid (AA) and docosahexaenoic acid (DHA) in brain membrane phospholipids are rapid and energy consuming and that phospholipase A(2) (PLA(2)) and acyl-..
  14. pmc Aging is associated with altered inflammatory, arachidonic acid cascade, and synaptic markers, influenced by epigenetic modifications, in the human frontal cortex
    Vasken L Keleshian
    Brain Physiology and Metabolism Section, Laboratory of Neurosciences, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892 0947, USA
    J Neurochem 125:63-73. 2013
    ..To test this hypothesis, we measured markers of the arachidonic acid (AA) cascade, neuroinflammation, pro- and anti-apoptosis factors, and gene specific epigenetic modifications ..
  15. ncbi Lipopolysaccharide-induced release of arachidonic acid and prostaglandins in liver macrophages: regulation by Group IV cytosolic phospholipase A2, but not by Group V and Group IIA secretory phospholipase A2
    Peter Dieter
    Institute of Physiological Chemistry, Medical Faculty Carl Gustav Carus, Technical University Dresden, Fetscherstrasse 74, D 01307, Dresden, Germany
    Cell Signal 14:199-204. 2002
    Lipopolysaccharide (LPS) induces a delayed release (lag phase of 2-4 h) of arachidonic acid (AA) and prostaglandin (PG) D2 in rat liver macrophages...
  16. ncbi Critical role of arachidonic acid-activated mTOR signaling in breast carcinogenesis and angiogenesis
    Z H Wen
    Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
    Oncogene 32:160-70. 2013
    The mammalian target of rapamycin (mTOR) signaling pathway is upregulated in the pathogenesis of many cancers. Arachidonic acid (AA) and its metabolites play critical role in the development of breast cancer, but the mechanisms through ..
  17. ncbi Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats
    Beshay N M Zordoky
    Faculty of Pharmacy and Pharmaceutical Sciences, 3126 Dentistry Pharmacy Centre, University of Alberta, Edmonton, AB, Canada T6G 2N8
    Drug Metab Dispos 36:2277-86. 2008
    ..Moreover, there is a strong correlation between P450-mediated arachidonic acid metabolites and the pathogenesis of cardiac hypertrophy...
  18. ncbi Acute doxorubicin toxicity differentially alters cytochrome P450 expression and arachidonic acid metabolism in rat kidney and liver
    Beshay N M Zordoky
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB, Canada
    Drug Metab Dispos 39:1440-50. 2011
    ..induces several cardiac cytochrome P450 (P450) enzymes with subsequent alteration in P450-mediated arachidonic acid metabolism...
  19. ncbi Regulation of arachidonic acid availability for eicosanoid production
    Christina C Leslie
    Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA
    Biochem Cell Biol 82:1-17. 2004
    Mammalian cells have developed specific pathways for the incorporation, remodeling, and release of arachidonic acid. Acyltransferase and transacylase pathways function to regulate the levels of esterified arachidonic acid in specific ..
  20. ncbi Polyunsaturated fatty acids, inflammatory processes and inflammatory bowel diseases
    Philip C Calder
    Institute of Human Nutrition, School of Medicine, University of Southampton, Southampton, UK
    Mol Nutr Food Res 52:885-97. 2008
    With regard to inflammatory processes, the main fatty acids of interest are the n-6 PUFA arachidonic acid (AA), which is the precursor of inflammatory eicosanoids like prostaglandin E(2) and leukotriene B(4), and the n-3 PUFAs ..
  21. ncbi Identification of calcium-independent phospholipase A2 (iPLA2) beta, and not iPLA2gamma, as the mediator of arginine vasopressin-induced arachidonic acid release in A-10 smooth muscle cells. Enantioselective mechanism-based discrimination of mammalian iPL
    Christopher M Jenkins
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:32807-14. 2002
    The agonist-stimulated release of arachidonic acid (AA) from cellular phospholipids in many cell types (e.g...
  22. ncbi Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling
    L Scorrano
    Consiglio Nazionale delle Ricerche Unit for the Study of Biomembranes at the Department of Biomedical Sciences, Viale Giuseppe Colombo 3, I-35121 Padova, Italy
    J Biol Chem 276:12035-40. 2001
    ..At variance from palmitic acid, however, arachidonic acid causes a PT at concentrations that do not cause PT-independent depolarization or respiratory inhibition, ..
  23. pmc Arachidonic acid and ion channels: an update
    H Meves
    Physiologisches Institut, Universitat des Saarlandes, Homburg Saar, Germany
    Br J Pharmacol 155:4-16. 2008
    b>Arachidonic acid (AA), a polyunsaturated fatty acid with four double bonds, has multiple actions on living cells. Many of these effects are mediated by an action of AA or its metabolites on ion channels...
  24. ncbi Lipid and fatty acid composition of the green oleaginous alga Parietochloris incisa, the richest plant source of arachidonic acid
    Chiara Bigogno
    The Microalgal Biotechnology Laboratory, The Albert Katz Department for Drylands Biotechnologies, The Jacob Blaustein Institute for Desert Research, Ben Gurion University of the Negev, Beer Sheva, Israel
    Phytochemistry 60:497-503. 2002
    ..Tateyama, Japan, was found to be the richest plant source of the pharmaceutically valuable LC-PUFA, arachidonic acid (AA, 20:4omega6)...
  25. ncbi Dietary modification of inflammation with lipids
    Philip C Calder
    Institute of Human Nutrition, University of Southampton, Bassett Crescent East, UK
    Proc Nutr Soc 61:345-58. 2002
    ..Typically, human inflammatory cells contain high proportions of the n-6 PUFA arachidonic acid and low proportions of n-3 PUFA...
  26. ncbi Transgenic production of arachidonic acid in oilseeds
    James R Petrie
    Food Futures National Research Flagship, CSIRO Plant Industry, PO Box 1600, Canberra, ACT, 2601, Australia
    Transgenic Res 21:139-47. 2012
    ..pathway transformed in both Brassica napus and Arabidopsis thaliana seed resulting in the production of arachidonic acid (ARA)...
  27. ncbi The roles of CYP450 epoxygenases and metabolites, epoxyeicosatrienoic acids, in cardiovascular and malignant diseases
    Xizhen Xu
    Department of Internal Medicine and Institute of Hypertension, Tongji Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430030, PR China
    Adv Drug Deliv Rev 63:597-609. 2011
    Cytochrome P450 (CYP) epoxygenases metabolize arachidonic acid to biologically active eicosanoids. The primary epoxidation products are four regioisomers of cis-epoxyeicosatrienoic acid (EET): 5,6-, 8,9-, 11,12-, and 14,15-EET...
  28. ncbi Polyunsaturated fatty acids in plasma and erythrocyte membrane lipids of diabetic children
    T Decsi
    Department of Paediatrics, University of Pecs, Pecs, Hungary
    Prostaglandins Leukot Essent Fatty Acids 67:203-10. 2002
    ..07 [0.07], P<0.05) were significantly higher in diabetic children than in controls. In contrast, values of arachidonic acid (10.73 [2.34] vs. 11.53 [2.50], P<0.05) and docosahexaenoic acid (2.23 [0.63] vs. 2.77 [0.98], P<0...
  29. ncbi Formation of 20-hydroxyeicosatetraenoic acid, a vasoactive and natriuretic eicosanoid, in human kidney. Role of Cyp4F2 and Cyp4A11
    J M Lasker
    Department of Biochemistry, Mount Sinai School of Medicine, New York, New York 10029, USA
    J Biol Chem 275:4118-26. 2000
    20-hydroxyeicosatetraenoic acid (20-HETE), an omega-hydroxylated arachidonic acid (AA) metabolite, elicits specific effects on kidney vascular and tubular function that, in turn, influence blood pressure control...
  30. ncbi Influence of dietary fatty acids on endocannabinoid and N-acylethanolamine levels in rat brain, liver and small intestine
    Andreas Artmann
    Department of Pharmacology and Pharmacotherapy, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark
    Biochim Biophys Acta 1781:200-12. 2008
    ..rats five different dietary fats (palm oil (PO), olive oil (OA), safflower oil (LA), fish oil (FO) and arachidonic acid (AA)) on tissue levels of 2-arachidonoylglycerol, anandamide, oleoylethanolamide, palmitoylethanolamide, ..
  31. ncbi Amyloid beta peptide and NMDA induce ROS from NADPH oxidase and AA release from cytosolic phospholipase A2 in cortical neurons
    Phullara B Shelat
    Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
    J Neurochem 106:45-55. 2008
    ..signal-regulated kinase 1/2, phosphorylation of cytosolic phospholipase A(2)alpha (cPLA(2)alpha), and arachidonic acid (AA) release...
  32. ncbi P-450 metabolites of arachidonic acid in the control of cardiovascular function
    Richard J Roman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Physiol Rev 82:131-85. 2002
    Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxyeicosatrienoic ..
  33. ncbi Beta-subunit-dependent modulation of hSlo BK current by arachidonic acid
    X Sun
    Department of Pediatrics, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92037 0735, USA
    J Neurophysiol 97:62-9. 2007
    In this study, we examined the effect of arachidonic acid (AA) on the BK alpha-subunit with or without beta-subunits expressed in Xenopus oocytes...
  34. ncbi Costimulation of dectin-1 and DC-SIGN triggers the arachidonic acid cascade in human monocyte-derived dendritic cells
    Isela Valera
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas, Universidad de Valladolid, Valladolid, Spain
    J Immunol 180:5727-36. 2008
    Inflammatory mediators derived from arachidonic acid (AA) alter the function of dendritic cells (DC), but data regarding their biosynthesis resulting from stimulation of opsonic and nonopsonic receptors are scarce...
  35. ncbi Oxidative stress and arachidonic acid mobilization
    María A Balboa
    Institute of Molecular Biology and Genetics Spanish Research Council and University of Valladolid School of Medicine Calle Sanz y Forés s n, 47003 Valladolid, Spain
    Biochim Biophys Acta 1761:385-91. 2006
    ..The participation of Ca2+-dependent and Ca2+-independent phospholipase A2s in arachidonic acid mobilization from phospholipids is discussed, with particular attention to the interplay between cytosolic ..
  36. ncbi Inhibition effect of arachidonic acid on hypoxia-induced [Ca(2+)](i) elevation in PC12 cells and human pulmonary artery smooth muscle cells
    Fei Meng
    Department of Physiology, The Medical School, University of Birmingham, Vincent Drive, Birmingham, UK
    Respir Physiol Neurobiol 162:18-23. 2008
    ..In this study, we investigated the effect of arachidonic acid (AA), the upstream substrate for PGs, on hypoxia response in O(2) sensitive cells...
  37. ncbi Arachidonic acid metabolism as a potential mediator of cardiac fibrosis associated with inflammation
    Scott P Levick
    Cell and Developmental Biology and Anatomy, School of Medicine, University of South Carolina, Columbia, SC 29208, USA
    J Immunol 178:641-6. 2007
    ..Inflammatory cells are capable of releasing arachidonic acid, which may be further metabolized by cyclooxygenase, lipoxygenase, and cytochrome P450 monooxygenase enzymes ..
  38. pmc Treatment with docosahexaenoic acid, but not eicosapentaenoic acid, delays Ca2+-induced mitochondria permeability transition in normal and hypertrophied myocardium
    Ramzi J Khairallah
    Division of Cardiology and Department of Medicine, University of Maryland, Baltimore, MD 21201, USA
    J Pharmacol Exp Ther 335:155-62. 2010
    ..These results show that supplementation with DHA alone effectively increases both DHA and EPA in cardiac mitochondrial phospholipids and delays MPTP and suggest that treatment with DHA + EPA offers no advantage over DHA alone...
  39. ncbi FADS genotypes and desaturase activity estimated by the ratio of arachidonic acid to linoleic acid are associated with inflammation and coronary artery disease
    Nicola Martinelli
    Department of Clinical and Experimental Medicine and the Section of Biology and Genetics, University of Verona, Verona, Italy
    Am J Clin Nutr 88:941-9. 2008
    ..in polyunsaturated fatty acid (PUFA) metabolism that catalyze the conversion of linoleic acid (LA) into arachidonic acid (AA) and that of alpha-linolenic acid (ALA) into eicosapentaenoic acid (EPA)...
  40. pmc Altered neuroinflammatory, arachidonic acid cascade and synaptic markers in postmortem Alzheimer's disease brain
    J S Rao
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Transl Psychiatry 1:e31. 2011
    ..A recent positron emission tomography imaging study demonstrated upregulated brain arachidonic acid (AA) metabolism in AD patients...
  41. ncbi Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs
    Susumu Imaoka
    Nanobiotechnology Research Center and Department of Bioscience, School of Science and Technology, Kwansei Gakuin University, Hyogo, Japan
    Drug Metab Pharmacokinet 20:478-84. 2005
    Metabolites of arachidonic acid produced by P450 are interesting substances with prominent physiological functions...
  42. ncbi Arachidonic acid and colorectal carcinogenesis
    Raymond Jones
    Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968 0519, USA
    Mol Cell Biochem 253:141-9. 2003
    ..e. linoleic acid, arachidonic acid, etc.) may somehow be related with the disease process...
  43. pmc The N-terminal domain of Orai3 determines selectivity for activation of the store-independent ARC channel by arachidonic acid
    Jill Thompson
    Department of Pharmacology and Physiology, University of Rochester Medical Center, NY, USA
    Channels (Austin) 4:398-410. 2010
    ..channels" have been identified in native cells - the store-operated CRAC channels and the store-independent, arachidonic acid-activated ARC channels...
  44. pmc Cytochrome P450-derived eicosanoids: the neglected pathway in cancer
    Dipak Panigrahy
    Vascular Biology Program, Children s Hospital Boston, Boston, MA, USA
    Cancer Metastasis Rev 29:723-35. 2010
    ..A well-studied group of autacoids are the products of arachidonic acid metabolism, among which the prostaglandins and leukotrienes are the best known...
  45. pmc In vivo characterization of the first acyl-CoA Delta6-desaturase from a member of the plant kingdom, the microalga Ostreococcus tauri
    Frederic Domergue
    Biozentrum Klein Flottbek, Universitat Hamburg, Ohnhorststrasse 18, 22609 Hamburg, Germany
    Biochem J 389:483-90. 2005
    ..Altogether, our data suggest that this desaturase from O. tauri is an acyl-CoA Delta6-desaturase, the first one cloned from a photosynthetically active organism...
  46. ncbi Activation of p38 mitogen-activated protein kinase/cytosolic phospholipase A2 cascade in hydroperoxide-stressed platelets
    Laurent Coulon
    UMR 585 INSERM INSA Lyon, Villeurbanne, France
    Free Radic Biol Med 35:616-25. 2003
    12-Hydroperoxy-eicosatetraenoic acid (12-HpETE), the main hydroperoxide formed in platelets from arachidonic acid (AA) by 12-lipoxygenase, has been shown to increase the sensitivity of platelets to agonists resulting in increased ..
  47. pmc Differential metabolism of dihomo-gamma-linolenic acid and arachidonic acid by cyclo-oxygenase-1 and cyclo-oxygenase-2: implications for cellular synthesis of prostaglandin E1 and prostaglandin E2
    Galit Levin
    Department of Biochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Ramat Aviv 69978, Israel
    Biochem J 365:489-96. 2002
    ..acid (20:3 n-6; DGLA) and effective cyclo-oxygenase-dependent oxygenation of substrate DGLA relative to arachidonic acid (AA; 20:4 n-6)...
  48. ncbi Growth and development of preterm infants fed infant formulas containing docosahexaenoic acid and arachidonic acid
    M Thomas Clandinin
    University of Alberta, Edmonton, Alberta, Canada
    J Pediatr 146:461-8. 2005
    To evaluate safety and benefits of feeding preterm infants formulas containing docosahexaenoic acid (DHA) and arachidonic acid (ARA) until 92 weeks postmenstrual age (PMA), with follow-up to 118 weeks PMA.
  49. ncbi Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases
    Gema Perez-Chacon
    Instituto de Biologia y Genetica Molecular, Consejo Superior de Investigaciones Cientificas CSIC, 47003 Valladolid, Spain
    Biochim Biophys Acta 1791:1103-13. 2009
    b>Arachidonic acid (AA) and its oxygenated derivatives, collectively known as the eicosanoids, are key mediators of a wide variety of physiological and pathophysiological states...
  50. pmc A neuronal two P domain K+ channel stimulated by arachidonic acid and polyunsaturated fatty acids
    M Fink
    Institut de Pharmacologie Moléculaire et Cellulaire CNRS UPR 411, Valbonne, France
    EMBO J 17:3297-308. 1998
    ..A particularly salient feature of TRAAK is that they can be stimulated by arachidonic acid (AA) and other unsaturated fatty acids but not by saturated fatty acids...
  51. ncbi Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients
    M L Kowalski
    Department of Clinical Immunology and Allergy, Medical University, Lodz, Poland
    Am J Respir Crit Care Med 161:391-8. 2000
    ..Our results indicate that nasal polyps ECs from ASA-sensitive patients have significant abnormality in basal and ASA-induced generation of eicosanoids which may be causally related to the mechanism of ASA sensitivity...
  52. ncbi Suppression of ERK signaling evokes autocrine Fas-mediated death in arachidonic acid-treated human chronic myeloid leukemia K562 cells
    Ku Chung Chen
    Institute of Biomedical Sciences, Kaohsiung Medical University Joint Research Center, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    J Cell Physiol 222:625-34. 2010
    b>Arachidonic acid (AA)-induced apoptotic death of K562 cells (human chronic myeloid leukemic cells) was characteristic of reactive oxygen species (ROS) generation and mitochondrial depolarization...
  53. ncbi Genetic variants in the FADS gene cluster are associated with arachidonic acid concentrations of human breast milk at 1.5 and 6 mo postpartum and influence the course of milk dodecanoic, tetracosenoic, and trans-9-octadecenoic acid concentrations over the
    Eva Lattka
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Institute of Epidemiology, Neuherberg, Germany
    Am J Clin Nutr 93:382-91. 2011
    ....
  54. pmc Supplementation of arachidonic acid-enriched oil increases arachidonic acid contents in plasma phospholipids, but does not increase their metabolites and clinical parameters in Japanese healthy elderly individuals: a randomized controlled study
    Saki Kakutani
    Institute for Health Care Science, Suntory Wellness Ltd, Osaka, Japan
    Lipids Health Dis 10:241. 2011
    The importance of arachidonic acid (ARA) among the elderly has recently gained increased attention...
  55. ncbi Arachidonic acid activation of intratumoral steroid synthesis during prostate cancer progression to castration resistance
    Jennifer A Locke
    Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada
    Prostate 70:239-51. 2010
    ..Herein we provide evidence that fatty acids (FA) can trigger androgen synthesis within steroid starved prostate cancer (CaP) tumor cells...
  56. ncbi Arachidonic acid released by phospholipase A(2) activation triggers Ca(2+)-dependent apoptosis through the mitochondrial pathway
    Daniele Penzo
    Department of Biomedical Sciences, Consiglio Nazionale delle Ricerche Institute of Neuroscience at the University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 279:25219-25. 2004
    ..5 microm MK886 and 5 microm indomethacin, which inhibit arachidonic acid metabolism through the 5-lipoxygenase and cyclooxygenase pathway, respectively...
  57. pmc Altered expression of apoptotic factors and synaptic markers in postmortem brain from bipolar disorder patients
    Hyung Wook Kim
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neurobiol Dis 37:596-603. 2010
    ..There is evidence of excitotoxicity, neuroinflammation, upregulated arachidonic acid (AA) cascade signaling and brain atrophy in BD patients...
  58. ncbi The effects of oxidation products of arachidonic acid and n3 fatty acids on vascular and platelet function
    Anne Barden
    Cardiovascular Research Center, School of Medicine and Pharmacology, University of Western Australia, Royal Perth Hospital, Western Australia, Australia
    Free Radic Res 45:469-76. 2011
    15-F₂(t)-isoprostane (15-F₂(t)-IsoP), an oxidation product of arachidonic acid (AA), affects vascular and platelet function; however, the bioactivity of other fatty acids oxidation products is unknown...
  59. ncbi Anti-inflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor kappa B (NF-kappaB)
    João B Calixto
    Department of Pharmacology, CCB, Universidade Federal de Santa Catarina, Florianopolis, SC, Brazil
    Planta Med 69:973-83. 2003
    ..plant-derived constituents interfere with three relevant targets involved in the inflammatory process, namely arachidonic acid metabolite pathways, nitric oxide and NF-kappaB, and discusses their potential therapeutic use in the ..
  60. pmc Omega-3 fatty acid deficiency during brain maturation reduces neuronal and behavioral plasticity in adulthood
    Harsharan Singh Bhatia
    Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 6:e28451. 2011
    ..Adequate levels of dietary DHA seem crucial for building long-term neuronal resilience for optimal brain performance and aiding in the battle against neurological disorders...
  61. pmc Differences in arachidonic acid levels and fatty acid desaturase (FADS) gene variants in African Americans and European Americans with diabetes or the metabolic syndrome
    Susan Sergeant
    The Center for Botanical Lipids and Inflammatory Disease Prevention, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Br J Nutr 107:547-55. 2012
    ..Compared with European Americans (EAm), African Americans (AfAm) exhibited markedly higher serum levels of arachidonic acid (AA) (EAm 7·9 (sd 2·1), AfAm 9·8 (sd 1·9) % of total fatty acids; P < 2·29 × 10⁻⁹) and the AA:n-..
  62. pmc Characterization of an arachidonic acid-deficient (Fads1 knockout) mouse model
    Yang Yi Fan
    Program in Integrative Nutrition and Complex Diseases, Texas A and M University, College Station, TX 77843, USA
    J Lipid Res 53:1287-95. 2012
    b>Arachidonic acid (20:4(Δ5,8,11,14), AA)-derived eicosanoids regulate inflammation and promote cancer development. Previous studies have targeted prostaglandin enzymes in an attempt to modulate AA metabolism...
  63. ncbi Decreasing linoleic acid with constant alpha-linolenic acid in dietary fats increases (n-3) eicosapentaenoic acid in plasma phospholipids in healthy men
    Y Angela Liou
    The Nutrition Research Program, Child and Family Research Institute, University of British Columbia, Vancouver, Canada V52 4H40
    J Nutr 137:945-52. 2007
    ..to eicosapentaenoic acid [EPA, 20:5(n-3)] and docosahexaenoic acid [DHA, 22:6(n-3)], and favor high arachidonic acid [ARA, 20:4(n-6)]...
  64. pmc Arachidonic acid pathway members PLA2G7, HPGD, EPHX2, and CYP4F8 identified as putative novel therapeutic targets in prostate cancer
    Paula Vainio
    Turku Centre for Biotechnology, University of Turku, Turku, Finland
    Am J Pathol 178:525-36. 2011
    The arachidonic acid and prostaglandin pathway has been implicated in prostate carcinogenesis, but comprehensive studies of the individual members in this key pathway are lacking...
  65. ncbi Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products
    Masayuki Wada
    Department of Biological Chemistry, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Biol Chem 282:22254-66. 2007
    ..Prostaglandins (PGs) and thromboxanes are produced in vivo both from the omega 6 fatty acid arachidonic acid (AA) and the omega 3 fatty acid eicosapentaenoic acid (EPA)...
  66. pmc Anandamide and diet: inclusion of dietary arachidonate and docosahexaenoate leads to increased brain levels of the corresponding N-acylethanolamines in piglets
    A Berger
    Nestle Research Center, Nestec Ltd, Vers chez les Blanc, CH 1000 Lausanne 26, Switzerland
    Proc Natl Acad Sci U S A 98:6402-6. 2001
    ....
  67. ncbi Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder?
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, Bldg 10, Room 6N202, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 59:592-6. 2002
    ..Lithium and certain anticonvulsants, including carbamazepine and valproic acid, are effective antimanic drugs for treating bipolar disorder, but their mechanisms of action remain uncertain...
  68. pmc Bipolar disorder and mechanisms of action of mood stabilizers
    Stanley I Rapoport
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA
    Brain Res Rev 61:185-209. 2009
    ..Suicide is common. Of the hypotheses regarding the action of mood stabilizers in BD, the "arachidonic acid (AA) cascade" hypothesis is presented in detail in this review...
  69. pmc DHA diet reduces AD pathology in young APPswe/PS1 Delta E9 transgenic mice: possible gender effects
    Sylvia E Perez
    Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois 60612, USA
    J Neurosci Res 88:1026-40. 2010
    ..Gas chromatography revealed a significant increase in DHA concomitant with a decrease of arachidonic acid in both brain and liver in mice fed with DHA...
  70. pmc Omega-6 and trans fatty acids in blood cell membranes: a risk factor for acute coronary syndromes?
    Robert C Block
    Division of Epidemiology, Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    Am Heart J 156:1117-23. 2008
    ..Although fatty acid intake has been associated with risk of coronary disease events, the association between blood omega-6 and trans fatty acids (FAs) at the time of an acute coronary syndrome (ACS) is unknown...
  71. pmc Arachidonic acid stimulates cell adhesion through a novel p38 MAPK-RhoA signaling pathway that involves heat shock protein 27
    Melissa C Garcia
    Laboratory of Molecular Carcinogenesis, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 284:20936-45. 2009
    ..Here we report that in MDA-MB-435 human melanoma cells, arachidonic acid activates RhoA, and inhibition of RhoA signaling with either C3 exoenzyme or dominant negative Rho blocked ..
  72. pmc Imaging neuroinflammation in Alzheimer's disease with radiolabeled arachidonic acid and PET
    Giuseppe Esposito
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Nucl Med 49:1414-21. 2008
    Incorporation coefficients (K*) of arachidonic acid (AA) in the brain are increased in a rat model of neuroinflammation, as are other markers of AA metabolism...
  73. ncbi Omega-3 and omega-6 fatty acids stimulate cell membrane expansion by acting on syntaxin 3
    Frédéric Darios
    MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK
    Nature 440:813-7. 2006
    ..the fusion of transport organelles with the plasma membrane; however, the identity of the molecular target of arachidonic acid has remained elusive...
  74. ncbi Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration
    R Langenbach
    Laboratory of Experimental Carcinogenesis and Mutagenesis, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Cell 83:483-92. 1995
    ..The homozygous mutant mice have reduced platelet aggregation and a decreased inflammatory response to arachidonic acid, but not to tetradecanoyl phorbol acetate...
  75. ncbi Arachidonic acid activates phosphatidylinositol 3-kinase signaling and induces gene expression in prostate cancer
    Millie Hughes-Fulford
    Department of Veterans Affairs Medical Center, 4150 Clement Street, San Francisco, CA 91421, USA
    Cancer Res 66:1427-33. 2006
    ..Using gene chip analysis, we have found that arachidonic acid, an omega-6 fatty acid, induced 11 genes that are regulated by nuclear factor-kappaB (NF-kappaB)...
  76. ncbi Identification and quantitation of unique fatty acid oxidation products in human atherosclerotic plaque using high-performance liquid chromatography
    E Waddington
    Department of Medicine, Royal Perth Hospital, Perth, Western Australia, Australia
    Anal Biochem 292:234-44. 2001
    ..51 +/- 0.17 ng/microg of linoleic acid), 15-hydroxyeicosatetranoic acid (HETE) (0.66 +/- 0.24 ng/microg of arachidonic acid), and 11-HETE (0.84 +/- 0...
  77. ncbi Dietary supplementation with eicosapentaenoic acid, but not with other long-chain n-3 or n-6 polyunsaturated fatty acids, decreases natural killer cell activity in healthy subjects aged >55 y
    F Thies
    Department of Biochemistry, University of Oxford, Oxford, United Kingdom
    Am J Clin Nutr 73:539-48. 2001
    ..Our objective was to determine the effect of dietary supplementation with oil blends rich in ALA, GLA, arachidonic acid (AA), DHA, or EPA plus DHA (fish oil) on the NK cell activity of human peripheral blood mononuclear cells...
  78. ncbi Antineoplastic effects of n-3 polyunsaturated fatty acids in combination with drugs and radiotherapy: preventive and therapeutic strategies
    G Calviello
    Institute of General Pathology, Catholic University, L go F Vito, 1, Rome 00168, Italy
    Nutr Cancer 61:287-301. 2009
    ..Different molecular mechanisms have been proposed to explain their effects, including alterations in arachidonic acid oxidative metabolism and metabolic conversion of n-3 PUFAs to novel discovered bioactive derivatives; ..
  79. pmc Activation of the acute inflammatory response alters cytochrome P450 expression and eicosanoid metabolism
    Katherine N Theken
    Division of Pharmacotherapy and Experimental Therapeutics, Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina, USA
    Drug Metab Dispos 39:22-9. 2011
    Cytochrome P450 (P450)-mediated metabolism of arachidonic acid regulates inflammation in hepatic and extrahepatic tissue...
  80. ncbi Cytochrome P450 and arachidonic acid bioactivation. Molecular and functional properties of the arachidonate monooxygenase
    J H Capdevila
    Departments of Medicine, Vanderbilt University Medical School, Nashville, TN 372323, USA
    J Lipid Res 41:163-81. 2000
    The demonstration of in vivo arachidonic acid epoxidation and omega-hydroxylation established the cytochrome P450 epoxygenase and omega/omega-1 hydroxylase as formal metabolic pathways and as members of the arachidonate metabolic cascade...
  81. ncbi Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases
    Beshay N M Zordoky
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada T6G 2N8
    Pharmacol Ther 125:446-63. 2010
    ..One of the important physiological roles of CYP enzymes is the metabolism of arachidonic acid. CYP epoxygenases such as CYP1A2, CYP2C, and CYP2J2 metabolize arachidonic acid to epoxyeicosatrienoic acids (..
  82. ncbi The role of arachidonic acid and its metabolites in insulin secretion from human islets of langerhans
    Shanta J Persaud
    Beta Cell Development and Function Group, Division of Reproductive Health, Endocrinology, and Development, King s College London, UK
    Diabetes 56:197-203. 2007
    The roles played by arachidonic acid and its cyclooxygenase (COX)-generated and lipoxygenase (LOX)-generated metabolites have been studied using rodent islets and insulin-secreting cell lines, but very little is known about COX and LOX ..
  83. ncbi Hepatitis B virus X protein promotes liver cell proliferation via a positive cascade loop involving arachidonic acid metabolism and p-ERK1/2
    Changliang Shan
    Department of Cancer Research, Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Institute for Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, China
    Cell Res 20:563-75. 2010
    ..Moreover, these released arachidonic acid metabolites were able to activate ERK1/2...
  84. ncbi Arachidonic acid release from mammalian cells transfected with human groups IIA and X secreted phospholipase A(2) occurs predominantly during the secretory process and with the involvement of cytosolic phospholipase A(2)-alpha
    Carine M Mounier
    Departments of Chemistry and Biochemistry, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 279:25024-38. 2004
    ..These results along with additional data resolve the paradox that efficient arachidonic acid release occurs with hGIIA-transfected cells, and yet exogenously added hGIIA is poorly able to liberate ..
  85. ncbi Ca2+ selectivity and fatty acid specificity of the noncapacitative, arachidonate-regulated Ca2+ (ARC) channels
    Olivier Mignen
    Department of Pharmacology and Physiology, University of Rochester Medical Center, New York 14642, USA
    J Biol Chem 278:10174-81. 2003
    ..Examination of the ability of various fatty acids, including arachidonic acid, to activate the ARC channels demonstrated that activation does not reflect any nonspecific membrane fluidity ..
  86. ncbi Mitochondrial localization of cyclooxygenase-2 and calcium-independent phospholipase A2 in human cancer cells: implication in apoptosis resistance
    Jun Yang Liou
    Vascular Biology Research Center and Division of Hematology, Institute of, Molecular Medicine and Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030 1503, USA
    Exp Cell Res 306:75-84. 2005
    ..HT-29 which expressed more abundant mitochondrial COX-2 than DLD-1 was highly resistant to arachidonic acid and H2O2-induced apoptosis whereas DLD-1 was less resistant and human fibroblasts were highly susceptible...
  87. ncbi Growth and development in preterm infants fed long-chain polyunsaturated fatty acids: a prospective, randomized controlled trial
    D L O'Connor
    Ross Products Division, Abbott Labs, Columbus, Ohio, USA
    Pediatrics 108:359-71. 2001
    ..of supplementing premature infant formulas with oils containing the long-chain polyunsaturated fatty acids, arachidonic acid (AA; 20:4 n6), and docosahexaenoic acid (DHA; 22:6 n3) on growth, visual acuity, and multiple indices of ..
  88. ncbi Arachidonic acid relaxes human pulmonary arteries through K+ channels and nitric oxide pathways
    Pascal Guerard
    Laboratory of Cardiovascular Physiopathology and Pharmacology, Faculty of Medicine, 7 bd Jeanne d Arc, BP 87900, 21079 Dijon Cedex, France
    Eur J Pharmacol 501:127-35. 2004
    We aimed to investigate the role of K(+) channels and nitric oxide (NO) on the relaxant effects of arachidonic acid in the human intralobar pulmonary arteries...
  89. ncbi Arachidonic acid supplementation enhances in vitro skeletal muscle cell growth via a COX-2-dependent pathway
    James F Markworth
    School of Exercise and Nutrition Science, Deakin University, Melbourne, Australia
    Am J Physiol Cell Physiol 304:C56-67. 2013
    b>Arachidonic acid (AA) is the metabolic precursor to a diverse range of downstream bioactive lipid mediators. A positive or negative influence of individual eicosanoid species [e.g...
  90. pmc Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels
    Daniel K Nomura
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, 115 Wellman Hall, University of California, Berkeley, CA 94720 3112, USA
    Bioorg Med Chem Lett 18:5875-8. 2008
    ..We find for the first time that MAGL activity is a major in vivo determinant of 2-AG and arachidonic acid levels not only in brain but also in spleen, lung, and liver...
  91. pmc Regulation of arachidonate remodeling enzymes impacts eosinophil survival during allergic asthma
    Michael C Seeds
    Department of Internal Medicine Sections on Molecular Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Am J Respir Cell Mol Biol 41:358-66. 2009
    Although the role of arachidonic acid (AA) metabolism to eicosanoids has been well established in allergy and asthma, recent studies in neoplastic cells have revealed that AA remodeling through phospholipids impacts cell survival...
  92. pmc Imaging upregulated brain arachidonic acid metabolism in HIV-1 transgenic rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 31:486-93. 2011
    ..virus-bearing monocytes into the brain, followed by microglial activation, neuroinflammation, and upregulated arachidonic acid (AA) metabolism...
  93. pmc Influence of omega-6 PUFA arachidonic acid and bone marrow adipocytes on metastatic spread from prostate cancer
    M D Brown
    Genito Urinary Cancer Research Group, School of Cancer, Enabling Sciences and Technology, Paterson Institute for Cancer Research, The University of Manchester, Manchester Academic Health Science Centre, the Christie NHS Foundation Trust, Manchester M20 4BX, UK
    Br J Cancer 102:403-13. 2010
    ..metastasises to the bone, and we have previously shown that the poly-unsaturated fatty acid (PUFA) arachidonic acid (AA) is a potent stimulator of CaP invasion...
  94. ncbi 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and the action of arachidonic acid and PGE2
    B D Boyan
    Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 78284 7774, USA
    Steroids 64:129-36. 1999
    ..At the cellular level, 1,25 action results in rapid changes in arachidonic acid (AA) release and re-incorporation, alterations in membrane fluidity and Ca ion flux, and increased ..
  95. ncbi Toward optimizing vision and cognition in term infants by dietary docosahexaenoic and arachidonic acid supplementation: a review of randomized controlled trials
    Dennis R Hoffman
    Retina Foundation of the Southwest, 9900 N Central Expwy, Dallas, TX 75231, USA
    Prostaglandins Leukot Essent Fatty Acids 81:151-8. 2009
    The question of whether a dietary supply of docosahexaenoic acid (DHA) and arachidonic acid (ARA) imparts advantages to visual or cognitive development in term infants has been debated for many years...
  96. pmc Endothelial cell prostaglandin I(2) and platelet-activating factor production are markedly attenuated in the calcium-independent phospholipase A(2)beta knockout mouse
    Janhavi Sharma
    Department of Pathology, Saint Louis University School of Medicine, St Louis, Missouri 63104, USA
    Biochemistry 49:5473-81. 2010
    ..lung (HMVEC-L) results in activation of a calcium-independent phospholipase A(2) (iPLA(2)), and this leads to arachidonic acid release and production of prostaglandin I(2) (PGI(2)) and platelet-activating factor (PAF)...
  97. ncbi Clinical and cellular effects of cytochrome P-450 modulators
    Y Tesfaigzi
    Lovelace Respiratory Research Institute, 2425 Ridgecrest Dr SE, Albuquerque, NM 87108, USA
    Respir Physiol 128:79-87. 2001
    ..cytochrome P-450 enzymes (CYP), referred to as epoxygenases, are also involved in the metabolism of arachidonic acid, implicating epoxygenases in regulating inflammation and the generation of fever...
  98. ncbi Increased macrophage cholesterol biosynthesis and decreased cellular paraoxonase 2 (PON2) expression in Delta6-desaturase knockout (6-DS KO) mice: beneficial effects of arachidonic acid
    Mira Rosenblat
    The Lipid Research Laboratory, Technion Faculty of Medicine, The Rappaport Family Institute for Research in the Medical Sciences, Rambam Medical Center, 31096 Haifa, Israel
    Atherosclerosis 210:414-21. 2010
    To analyze the possible role of arachidonic acid (AA) in macrophage cholesterol biosynthesis and in PON2 expression.
  99. ncbi High dietary omega-6 fatty acids contribute to reduced docosahexaenoic acid in the developing brain and inhibit secondary neurite growth
    Elizabeth M Novak
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, Vancouver, B C, Canada
    Brain Res 1237:136-45. 2008
    ..fatty acid, 18:3omega-3 and the balance with the omega-6 fatty acid, 18:2omega-6, and the effects of dietary arachidonic acid (20:4omega-6) and DHA in milk diets using the piglet as a model of early infant nutrition...
  100. ncbi DNA methylation, induced by beta-carotene and arachidonic acid, plays a regulatory role in the pro-angiogenic VEGF-receptor (KDR) gene expression in endothelial cells
    B Kiec-Wilk
    Department of Medical Biochemistry, Jagiellonian University Medical College, Cracow, Poland
    J Physiol Pharmacol 60:49-53. 2009
    DNA methylation is a potent regulator of gene expression. The influence of beta-carotene (BC) and arachidonic acid (AA) on angiogenesis--a new blood vessel formation, was reported...
  101. ncbi Arachidonic acid modulates Na+ currents by non-metabolic and metabolic pathways in rat cerebellar granule cells
    Yan Jia Fang
    Institute of Brain Science, School of Life Sciences and State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200433, China
    Biochem J 438:203-15. 2011
    AA (arachidonic acid), which possesses both neurotoxic and neurotrophic activities, has been implicated as a messenger in both physiological and pathophysiological processes...

Research Grants70

  1. Soluble Epoxide Hydrolase as a Target for Ischemic Cardioprotection
    Donna M Van Winkle; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The P450 epoxygenase pathway breaks down arachidonic acid into epoxyeicosatrienoic acids (EETs)...
  2. REGULATION OF GENE EXPRESSION BY DIETARY FAT
    Lisa M Salati; Fiscal Year: 2012
    ..the rate of RNA splicing is inhibited in liver and primary hepatocytes by dietary polyunsaturated fat and by arachidonic acid, respectively...
  3. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..by an increase in the expression and activity of cPLA2 and iPLA , which liberate free fatty acids, including arachidonic acid, and lysophospholipids from membrane phospholipids...
  4. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..TRPV4 responds to mechanical sheer stress, osmotic changes, as well as certain arachidonic acid metabolites released during inflammation...
  5. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..Phospholipases A generate fatty acids and receptor-active lysophospholipids. Arachidonic acid is metabolized to leukotrienes and prostaglandins that have well established roles in physiologic and ..
  6. Fatty Acids, Eicosanoids and Inflammation
    Eric K Long; Fiscal Year: 2012
    ..LTA4 is formed by liberation of arachidonic acid from phospholipid membranes and subsequent metabolism by 5-lipoxygenase and 5-lipoxygenase activating protein...
  7. Intestinal Inflammation Induced by Pathogens
    Beth A McCormick; Fiscal Year: 2013
    ..HXA3 is a derivative of arachidonic acid formed from the enzymatic action of the 12-lipoxygenase (12-LO) pathway...
  8. Therapeutic Strategies for Neonatal Hypoxic-Ischemic Encephalopathy
    RAYMOND CHARLES KOEHLER; Fiscal Year: 2012
    ..The arachidonic acid metabolite 20-HETE is also known to decrease Na,K-ATPase activity, but by PKC-dependent phosphorylation...
  9. Role of lipoxygenase pathway in early microvascular dysfunction during diabetic r
    MOHAMED AL SAYED AL-SHABRAWEY; Fiscal Year: 2013
    ..Diabetic dyslipidemia is characterized by an increase in arachidonic acid (AA) which is further metabolized by 12/15-lipoxygenase and other enzymatic pathways into proinflammatory ..
  10. Pathogenic Mechanisms of Pancreatitis
    Rodger A Liddle; Fiscal Year: 2013
    ..Factors that stimulate primary sensory neurons include hydrogen ions, heat, leukotrienes, arachidonic acid metabolites, bradykinin, and proteases such as trypsin, all of which may participate in the generation of ..
  11. Estrogen, Aging and Vascular Inflammation
    Anne A Knowlton; Fiscal Year: 2013
    ..EETs represent the third pathway of arachidonic acid (AA) metabolism, in addition to prostaglandins and leukotrienes...
  12. Eicosanoids and Endothelial Cell Dysfunction
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Phospholipase A2s (PLA2s) play an important role in inflammation. Arachidonic acid (AA), which is produced primarily by PLA2s, metabolizes via the cyclooxygenase (COX), lipoxygenase (LOX) and ..
  13. Fatty acid desaturase activity, fish oil and colorectal cancer chemoprevention
    Harvey J Murff; Fiscal Year: 2013
    ..This ratio is important because the n-6 PUFA, arachidonic acid (ARA), is converted via the cyclo-oxygenase pathway to prostaglandin E2 (PGE2), an inflammatory eicosanoid ..
  14. Microdialysis Studies of Seizure-Induced Oxidative Stress
    Craig E Lunte; Fiscal Year: 2013
    ..A new analytical method will be developed to detect prostanoids resulting from arachidonic acid metabolism. Three experimental models of epilepsy will be used in Wistar rats...
  15. Adiposity and Outcomes of Clinically Localized Prostate Cancer
    Vincent L Freeman; Fiscal Year: 2013
    ..fatty acids, the IGF-1 receptor signaling pathway, adipose tissue-derived cytokines, eicosanoids products of arachidonic acid, and metabolites of estrogen and testosterone...
  16. Colonic Cytokinetics and Cell Signaling: Dietary Effects
    ROBERT STEPHEN CHAPKIN; Fiscal Year: 2012
    ..In contrast, dietary lipids rich in n-6 PUFA, e.g., linoleic acid (LA) and arachidonic acid (AA), enhance the development of colon tumors...
  17. Chemistry, Structure and Biology of Thiol Transferases
    Richard N Armstrong; Fiscal Year: 2013
    ..Specific Aim 1c is will elucidate the structural details of the interaction of FLAP with arachidonic acid and its interaction with 5-lipoxigenase (5-LOX) in the initiation of the lipoxygenase pathway for the ..
  18. Mechanisms of Renoprotection by Soluble Epoxide Hydrolase Inhibition
    Deanna L Kroetz; Fiscal Year: 2013
    ..epoxyeicosatrienoic acids (EETs), which are major products of cytochrome P450 (CYP)-catalyzed metabolism of arachidonic acid, an essential fatty acid nutrient...
  19. LEUKOTRIENES AND DIABETIC RETINOPATHY
    Rose A Gubitosi-Klug; Fiscal Year: 2013
    ..Leukotrienes, metabolites of arachidonic acid, are potent mediators of inflammation in several diseases from asthma to atherosclerosis...
  20. Flow-induced coronary vasospasm in diabetic patients
    Zsolt Bagi; Fiscal Year: 2013
    ..with increases in intraluminal flow elevates endothelial [Ca2+]i, which via inducing phospholipase A2 and arachidonic acid release leads to enhanced production of thromboxane A2 in coronary vessels of T2-DM patients...
  21. Pharmacological Method to Accelerate Bone Fracture Healing
    J PATRICK O apos CONNOR; Fiscal Year: 2010
    ..This was based on the idea that when COX-2 is inhibited, arachidonic acid is shunted into the 5-LO pathway and the resulting metabolites slow fracture healing, as detailed in the ..
  22. Hydrogen Peroxide and Flow-Induced Dilation of Human Coronary Microcirculation
    David D Gutterman; Fiscal Year: 2012
    ..Both arachidonic acid metabolites and H2O2 are necessary for FMD, but preliminary studies point to H2O2 as the transferable dilator ..
  23. Role of P450 Eicosanoids in Delayed Microvascular Spasm Following Subarachnoid He
    DOMINIC AARON SILER; Fiscal Year: 2013
    ..Flow in brain microvessels is controlled by cytochrome P450 metabolites of arachidonic acid called epoxyeicosatrienoic acids (EETs). EETs are inactivated by the enzyme soluble epoxide hydrolase (sEH)...
  24. CD36 and Intestinal Fat Absorption
    Nada A Abumrad; Fiscal Year: 2013
    ..we found that the src-ERK pathway is also involved in CD36-mediated regulation of the synthesis of arachidonic acid derived pro- inflammatory eicosanoids...
  25. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael F Brown; Fiscal Year: 2010
    ..containing highly polyunsaturated fatty acids, including docosahexaenoic acid (DHA;22:6-omega-3) and arachidonic acid (20:4-omega-6). Alterations of visual function are found to occur in essential fatty acid deficiency...
  26. Human CYP1A1, diet and dioxin-induced hypertension
    Mary K Walker; Fiscal Year: 2012
    ..Further, TCDD increases arachidonic acid (AA)-mediated vasoconstriction and an ?-3 PUFA-enriched diet normalizes this effect...
  27. Targeting the Obesity-Inflammation-COX-Aromatase Axis to Lower Breast Cancer Risk
    ANDREW JESS DANNENBERG; Fiscal Year: 2013
    ..Therefore, the goal of this proposal is to evaluate strategies for disrupting arachidonic acid metabolism and thereby suppressing the PGE2->aromatase axis, with the ultimate goal of "normalizing" the ..
  28. Role of Astrocytic TREK-2 Potassium Channels in Cerebral Ischemia
    Misty J Eaton; Fiscal Year: 2013
    ..During ischemia, activation of phospholipases promotes liberation and accumulation of arachidonic acid, the intracellular pH of astrocytes becomes acidic and astrocytes swell...
  29. P450 Epoxygenase Mechanisms of Opioid Analgesia
    LINDSAY HOUGH; Fiscal Year: 2013
    ..Many P450s have arachidonic acid (AA) epoxygenase activity, i.e. they convert AA to epoxyeicosatrienoic acids (EETs)...
  30. Mechanisms of Inflammatory Lung Disease in Neonates
    BARRY I WEINBERGER; Fiscal Year: 2010
    ..the inflammatory response is regulated by sequential changes in the production of eicosanoids generated from arachidonic acid via cyclooxygenase-2 and lipoxygenase...
  31. Bioactive lipids in food and pharmaceutical products
    Eric J Haas-Stapleton; Fiscal Year: 2013
    ..In most human cells, PGE2 is biosynthesized via sequential oxidation of arachidonic acid (AA) by cyclooxygenases (COX) and prostaglandin E2 synthase (PTGES)...
  32. EET-Induced Cardioprotection: Role of Opioids and Nitric Oxide (NO)
    John A Auchampach; Fiscal Year: 2013
    ..The novel CYP-epoxygenase metabolites of arachidonic acid (AA), 11,12- and 14,15-epoxyeicosatrienoic acids (EETs) are increased during ischemia and particularly ..
  33. Counter-Regulatory Lipid Mediators in Lung Disease
    Bruce D Levy; Fiscal Year: 2012
    ..Lipoxins are arachidonic acid-derived autacoids that also display protective actions in acute lung injury and regulate leukocyte actions ..
  34. EICOSANOIDS AND VASCULAR WALL REMODELING
    Gadiparthi N Rao; Fiscal Year: 2013
    ..Phospholipase A2s (PLA2s) play an important role in inflammation. Arachidonic acid (AA), which is produced primarily by PLA2s, metabolizes via the cyclooxygenase (COX), lipoxygenase (LOX) and ..
  35. 15-lipoxygenase regulation of mucosal immunity in allergic airways disease
    Douglas A Kuperman; Fiscal Year: 2011
    ..as well as to test hypotheses that we have developed that this system is regulated by the metabolism of arachidonic acid by the 12/15-LO pathway...
  36. GABA-B-R-mediated prevention of pancreatic cancer
    Hildegard M Schuller; Fiscal Year: 2013
    ..while additionally triggering the release of epidermal growth factor, vascular endothelial growth factor and arachidonic acid. NNK activates this signaling pathway directly by binding to b-ARs and indirectly by stimulating the ..
  37. Long-Chain Fatty Acids, Oxidative Stress and Colorectal Neoplasm Risk
    Harvey J Murff; Fiscal Year: 2013
    ..Eicosapentanoic acid exhibits anti- inflammatory actions while arachidonic acid, an omega-6 polyunsaturated fatty acid, appears pro- inflammatory...
  38. MOLECULAR PROPERTIES OF IONIC PERMEABILITY IN NERVE
    Bertil Hille; Fiscal Year: 2012
    ..The ability of arachidonic acid to modulate KCNQ and Cav channels will be analyzed...
  39. Linear quadrupole/linear ion trap LC/MS/MS mass spectrometer
    Rodney C Baker; Fiscal Year: 2010
    ..of coilin, which is involved in Cajal body formation;Identification and quantification of arachidonic acid metabolites and estrogenic compounds which are proposed to contribute to hypertension;and identification of ..
  40. Effect of FADS gene variants on fatty acid synthesis &brain development in India
    AVINASH KUNJAN SHETTY; Fiscal Year: 2013
    ..by applicant): Long-chain polyunsaturated fatty acid (LC-PUFA), such as docosahexaenoic acid (DHA) and arachidonic acid (AA) are vital for brain and eye development...
  41. Lipidomic and Transcriptome Signatures in Aspirin-Exacerbated Respiratory Disease
    Joshua A Boyce; Fiscal Year: 2010
    ..Our preliminary data indicate that respiratory tissue from individuals with AERD avidly metabolize arachidonic acid to at least three major metabolites, one of which we identified at 15-HETE;the other 2 metabolites have not ..
  42. Control of cancer and metastasis by endothelial-derived epoxyeicosatrienoic acids
    Dipak Panigrahy; Fiscal Year: 2013
    ..recently discovered that the epoxyeicosatrienoic acids (EETs), which are cytochrome P450 (CYP) metabolites of arachidonic acid (AA), have potent tumor promoting activities...
  43. HIV-induced 5-Lipoxygenase: Role in HIV-related Pulmonary Arterial Hypertension
    KRISTI MICHELLE PORTER; Fiscal Year: 2010
    ..AL0X5 is the enzyme that produces leukotrienes (LT) from arachidonic acid. These LT include LTB4 and the potent vasoconstrictors, LTC4, LTD4 and LTE4...
  44. (R)-flurbiprofen Substrate-Selective Inhibition of COX-2 and Analog Development
    Daniel Hermanson; Fiscal Year: 2013
    ..be more potent with respect to the inhibition of endocannabinoid oxygenation as compared to the inhibition of arachidonic acid (AA) oxygenation...
  45. 15-LOX-1 effects on colitis and colon cancer
    Imad Shureiqi; Fiscal Year: 2012
    ..Inflammation contributes to colon carcinogenesis. Prostaglandin E2 (PGE2), a proinflammatory product of arachidonic acid, activates peroxisome proliferator-activated receptor-delta (PPAR-d) and promotes colonic tumorigenesis...
  46. Role of CYP P450s in the Regulation of Vascular Tone through Adenosine Receptors
    S Jamal Mustafa; Fiscal Year: 2013
    ..Recently, arachidonic acid (AA)-derived metabolites (EETs &20-HETE) through CYP450s have emerged as important mediators in ..
  47. Lipid Tandem Quadrupole Mass Spectrometer
    ROBERT CARL MURPHY; Fiscal Year: 2010
    ..and lysophosphatidylserine metabolites relevant to cellular apoptosis, and quantitation of metabolites of arachidonic acid generated in studies of coculture of various tumor cells with primary cultures of macrophages and macrophage ..
  48. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..Recently, we reported that arachidonic acid (AA)-induced cerebrovasodilation is mediated by COX products, mainly prostaglandin E2 (PGE2), and that AA and ..
  49. HYDROLYTIC ENZYMES IN THE METABOLISM OF TOXINS
    Bruce D Hammock; Fiscal Year: 2013
    ..We have established that the soluble epoxide hydrolase also acts on epoxides of arachidonic acid. These are key regulatory lipids...
  50. Lipoxin-Mediated Inflammatory Resolution in Newborn Hyperoxic Lung Injury
    RODNEY BRITT; Fiscal Year: 2012
    ..Lipoxins (LX) are arachidonic acid derived lipids that have been shown to mediate inflammatory resolution by decreasing neutrophil and ..
  51. Regulation of opioid receptor function in trigeminal ganglion
    William P Clarke; Fiscal Year: 2012
    ..of competence, and the persistence of competence after induction, by administration of bradykinin (BK), arachidonic acid (AA) and naloxone...
  52. Anti-carcinogenic effects of White Tea on Lung Cancer
    Jenny T Mao; Fiscal Year: 2010
    ..Specific Aim 2: To evaluate the effects of WTE on arachidonic acid metabolism and PPAR- signaling pathway in an in vitro model of the lung microenvironment...
  53. CYTOCHROME P-450 AND GLOMERULAR PROTEIN PERMEABILITY
    Ellen T McCarthy; Fiscal Year: 2010
    ..Products of cytochrome P450 (CYP450) arachidonic acid metabolism are increasingly recognized as playing important roles in renal physiology...
  54. Role of 15-lipoxygenase in Enhanced Pulmonary Vasoconstriction in Females
    Sandra L Pfister; Fiscal Year: 2010
    ..evidence that in pulmonary arteries obtained from female rabbits, endothelium-dependent contractions to both arachidonic acid and methacholine were enhanced when compared to responses in males...
  55. Eicosanoid Regulation in Atherosclerosis: Involvement of Inducible NO Synthase
    David P Hajjar; Fiscal Year: 2010
    ..Prostaglandins (from arachidonic acid metabolism) and nitric oxide (7NO) produced in blood vessels are critical mediators in the regulation of ..
  56. 48th Annual South Eastern Regional Lipid Conference (SERLC) Funding Support
    Carole A Oskeritzian; Fiscal Year: 2013
    ..These enzymes initiate production of lipid ligands, including the eicosanoid metabolites of arachidonic acid and exert important functions in inflammation...
  57. Stress and Proinflammatory Cytokines: Omega-3 Intervention
    Janice Kiecolt Glaser; Fiscal Year: 2009
    ..Diet also influences the synthesis of these cytokines. Arachidonic acid (AA) derived (omega-6 or n-6) eicosanoids (primarily from refined vegetable oils such as corn, sunflower, and ..
  58. Studies of Eicosanoid Biosynthetic Proteins
    Wonhwa Cho; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Arachidonic acid (AA), which is liberated from membrane phospholipids by phospholipase A2 (PLA2), is converted to oxidized lipids collectively known as eicosanoids, including prostaglandins and ..
  59. Role of Eicosanoids in Renal Function
    NANCY JOAN BROWN; Fiscal Year: 2013
    ..The renal P450 arachidonic acid (AA) monooxygenase biosynthesizes hydroxy- and epoxy-AA derivatives that are known to modulate tubular ..
  60. Microcirculation in Health and Disease
    Robert L Hester; Fiscal Year: 2012
    ..We have demonstrated that arachidonic acid metabolites are important in the control of muscle blood flow...
  61. RECEPTOR-REGULATED CALCIUM ENTRY IN EXOCRINE SECRETION
    Trevor J Shuttleworth; Fiscal Year: 2013
    ..Of these, the arachidonic acid-regulated Ca2+-selective (ARC) channels, that we first described some 8 years ago, remain the most thoroughly ..
  62. Mechanisms of endothelial repair after vascular injury
    Zvonimir S Katusic; Fiscal Year: 2012
    ..Strikingly, the role of arachidonic acid metabolism and biosynthesis of PGI2 in regulation of regenerative function of EPCs has not been studied...
  63. PHOSPHOLIPID TURNOVER IN EXOCRINE PANCREAS
    Ronald Rubin; Fiscal Year: 1991
    ..g. 3H-inositol, 14C-arachidonic acid, 32P) to label phospholipids, inositol polyphosphates, arachidonic acid metabolites, and phosphoproteins...
  64. DIVALENT CATIONS AND CARDIAC LIPID METABOLISM
    MARGARET WEIS; Fiscal Year: 1990
    ..in the isolated perfused rabbit heart, the intracellular Mg2+ concentrations are important in regulating the arachidonic acid content and overall fatty acid composition of phospholipids...
  65. THE ROLE OF LIPOXINS IN BONE CELL METABOLISM
    Dimitris Tatakis; Fiscal Year: 1991
    Lipoxins, a novel class of arachidonic acid metabolites from the lipoxygenase pathway, have been recently shown to be involved in acute as well as chronic inflammatory reactions; these reactions have been implicated in bone resorption, ..
  66. ARACHIDONATE LIPOXYGENASE ACTIVITIES IN HUMAN PREGNANCY
    Murray Mitchell; Fiscal Year: 1992
    ..Products of arachidonic acid metabolism are intimately involved both in the normal regulatory events of pregnancy and in the ..
  67. METABOLIC AND MOLECULAR CONTROL OF MYELOPOIESIS
    Alan Miller; Fiscal Year: 1991
    ..CSF stimulates the release of arachidonic acid from membrane phospholipids, and arachidonic acid is then transformed to products of cyclooxygenation and ..
  68. SIGNAL TRANSDUCTION MECHANISMS AND AMNION PGE2 SYNTHESIS
    Leslie Myatt; Fiscal Year: 1993
    ..We have evidence that metabolism of arachidonic acid switches from lipoxygenase to cyclo-oxygenase pathways at parturition and that activation of protein kinase C ..
  69. CYTOCHROME P450 DEPENDENT ARACHIDONIC ACID METABOLISM
    Deanna Kroetz; Fiscal Year: 2004
    DESCRIPTION (Verbatim from Applicant's Abstract): The two major pathways of cytochrome P450 (CYP)-catalyzed arachidonic acid (AA) metabolism are omega-hydroxylation to form 20-hydroxyeicosatetraenoic acid (20-HETE) and epoxidation which ..
  70. EICOSANOID OXIDATION BY LIVER AND KIDNEY P450 ENZYMES
    Jerome Lasker; Fiscal Year: 2006
    ..now evident that P450 enzymes metabolize key cellular constituents, including long-chain fatty acid such as arachidonic acid (AA), leukotrienes (LT) such as LTB4, and other eicosanoids...