palmitic acid

Summary

Summary: A common saturated fatty acid found in fats and waxes including olive oil, palm oil, and body lipids.

Top Publications

  1. pmc Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells
    Muhammad Jadoon Khan
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria
    J Biol Chem 287:21110-20. 2012
  2. pmc Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin)
    Shi Hao Tan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597
    J Biol Chem 287:14364-76. 2012
  3. pmc Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    Laura L Listenberger
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1010, USA
    Proc Natl Acad Sci U S A 100:3077-82. 2003
  4. pmc Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    Haitao Wen
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Immunol 12:408-15. 2011
  5. ncbi Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    L L Listenberger
    Center for Cardiovascular Research, Departments of Internal Medicine, Molecular Biology, and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110-1010, USA
    J Biol Chem 276:14890-5. 2001
  6. pmc Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress
    Larysa Yuzefovych
    Dept of Cell Biology and Neuroscience, Univ of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Endocrinol Metab 299:E1096-105. 2010
  7. ncbi Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes
    Kolapo M Ajuwon
    Department of Animal Sciences, Center for Comparative Medicine, Purdue University, West Lafayette, IN 47907 2054, USA
    J Nutr 135:1841-6. 2005
  8. pmc Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes
    Shuang Mei
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center MS 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 339:487-98. 2011
  9. ncbi Protein palmitoylation by a family of DHHC protein S-acyltransferases
    David A Mitchell
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 47:1118-27. 2006
  10. ncbi Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004

Research Grants

  1. Role of Perilipin in Hepatic Steatosis and Metabolism
    Thomas A Bowman; Fiscal Year: 2013
  2. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
  3. Palmitate Metabolism and Insulin Resistance
    CRAIG LAWRENCE KIEN; Fiscal Year: 2013
  4. Mechanisms underlying metabolic syndrome in obesity
    Charlotte A Peterson; Fiscal Year: 2013
  5. Palmitic Acid Regulation of Dendritic Cell Toll-Like Receptor 4 Signaling
    DEQUINA ANGELINA NICHOLAS; Fiscal Year: 2013
  6. Mechanisms of Liver Inflammation
    Harmeet Malhi; Fiscal Year: 2013
  7. Dopamine Transporter Palmitoylation
    JAMES DARREN FOSTER; Fiscal Year: 2011
  8. DGAT1: Linking Fatty Acids to Inflammation and Metabolism in White Adipose Tissue
    SUNEIL KRISHNA KOLIWAD; Fiscal Year: 2013
  9. Saturated Fatty Acid and Cardiovascular Disease
    Eric J Smart; Fiscal Year: 2010
  10. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990

Detail Information

Publications372 found, 100 shown here

  1. pmc Inhibition of autophagy rescues palmitic acid-induced necroptosis of endothelial cells
    Muhammad Jadoon Khan
    Institute of Molecular Biology and Biochemistry, Center of Molecular Medicine, Medical University of Graz, 8010 Graz, Austria
    J Biol Chem 287:21110-20. 2012
    Accumulation of palmitic acid (PA) in cells from nonadipose tissues is known to induce lipotoxicity resulting in cellular dysfunction and death. The exact molecular pathways of PA-induced cell death are still mysterious...
  2. pmc Induction of autophagy by palmitic acid via protein kinase C-mediated signaling pathway independent of mTOR (mammalian target of rapamycin)
    Shi Hao Tan
    Saw Swee Hock School of Public Health, National University of Singapore, Singapore 117597
    J Biol Chem 287:14364-76. 2012
    ..In this study we sought to examine effects of palmitic acid (PA) and oleic acid, two of the common dietary fatty acids on the autophagic process...
  3. pmc Triglyceride accumulation protects against fatty acid-induced lipotoxicity
    Laura L Listenberger
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1010, USA
    Proc Natl Acad Sci U S A 100:3077-82. 2003
    ..Oleic acid supplementation leads to triglyceride accumulation and is well tolerated, whereas excess palmitic acid is poorly incorporated into triglyceride and causes apoptosis...
  4. pmc Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
    Haitao Wen
    Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Nat Immunol 12:408-15. 2011
    ..Furthermore, IL-1β affects insulin sensitivity through tumor necrosis factor-independent and dependent pathways. These findings provide insights into the association of inflammation, diet and T2D...
  5. ncbi Palmitate-induced apoptosis can occur through a ceramide-independent pathway
    L L Listenberger
    Center for Cardiovascular Research, Departments of Internal Medicine, Molecular Biology, and Pharmacology, Washington University School of Medicine, St. Louis, Missouri 63110-1010, USA
    J Biol Chem 276:14890-5. 2001
    ..These studies suggest that generation of reactive oxygen species, independent of ceramide synthesis, is important for the lipotoxic response and may contribute to the pathogenesis of diseases involving intracellular lipid accumulation...
  6. pmc Different effects of oleate vs. palmitate on mitochondrial function, apoptosis, and insulin signaling in L6 skeletal muscle cells: role of oxidative stress
    Larysa Yuzefovych
    Dept of Cell Biology and Neuroscience, Univ of South Alabama, Mobile, AL 36688, USA
    Am J Physiol Endocrinol Metab 299:E1096-105. 2010
    ....
  7. ncbi Palmitate activates the NF-kappaB transcription factor and induces IL-6 and TNFalpha expression in 3T3-L1 adipocytes
    Kolapo M Ajuwon
    Department of Animal Sciences, Center for Comparative Medicine, Purdue University, West Lafayette, IN 47907 2054, USA
    J Nutr 135:1841-6. 2005
    ..Furthermore, PI3K may act constitutively to suppress inflammation. Consequently, inhibition of this enzyme may promote and exacerbate the inflammation in adipose tissue that is associated with obesity and insulin resistance...
  8. pmc Differential roles of unsaturated and saturated fatty acids on autophagy and apoptosis in hepatocytes
    Shuang Mei
    Department of Pharmacology, Toxicology and Therapeutics, The University of Kansas Medical Center MS 1018, 3901 Rainbow Blvd, Kansas City, KS 66160, USA
    J Pharmacol Exp Ther 339:487-98. 2011
    ..In contrast, the saturated fatty acid, palmitic acid, was poorly converted into triglyceride-enriched lipid droplets, suppressed autophagy, and significantly ..
  9. ncbi Protein palmitoylation by a family of DHHC protein S-acyltransferases
    David A Mitchell
    Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, USA
    J Lipid Res 47:1118-27. 2006
    ..This review presents the genetic and biochemical evidence for the PAT activity of DHHC proteins and discusses the mechanism of protein-mediated palmitoylation...
  10. ncbi Identification of PSD-95 palmitoylating enzymes
    Masaki Fukata
    Department of Physiology, University of California at San Francisco, San Francisco, California 94143, USA
    Neuron 44:987-96. 2004
    ..This study suggests that P-PATs regulate synaptic function through PSD-95 palmitoylation...
  11. ncbi Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells
    David A Zacharias
    Department of Pharmacology, Biomedical Sciences Graduate Program, and, Howard Hughes Medical Institute, University of California, San Diego, La Jolla, CA 92093 0647, USA
    Science 296:913-6. 2002
    ..Thus the nature of the lipid anchor on a protein is sufficient to determine submicroscopic localization within the plasma membrane...
  12. pmc Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance
    Nirupa Sachithanandan
    St Vincent s Institute of Medical Research and Department of Medicine, University of Melbourne, Fitzroy, Victoria, Australia
    Diabetes 60:2023-31. 2011
    ..In the current study, we investigated the physiological role of myeloid and lymphoid cell SOCS1 in regulating inflammation and insulin sensitivity...
  13. ncbi Palmitic acid induces production of proinflammatory cytokine interleukin-8 from hepatocytes
    Swati Joshi-Barve
    Department of Internal Medicine, the University of Louisville Medical Center, Louisville, KY 40292, USA
    Hepatology 46:823-30. 2007
    ..and human primary hepatocytes) by exposing them to pathophysiologically relevant concentrations of palmitic acid to simulate the excessive influx of fatty acids into hepatocytes...
  14. ncbi Saturated FFAs, palmitic acid and stearic acid, induce apoptosis in human granulosa cells
    Y M Mu
    Third Department of Internal Medicine, Faculty of Medicine, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan
    Endocrinology 142:3590-7. 2001
    ..In this study, we demonstrated that saturated FFAs, such as palmitic acid and stearic acid, markedly suppressed the granulosa cell survival in a time- and dose-dependent manner...
  15. ncbi Chronic palmitate but not oleate exposure induces endoplasmic reticulum stress, which may contribute to INS-1 pancreatic beta-cell apoptosis
    Elizabeth Karaskov
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 200 Elizabeth Street, MBRC 4R402 Toronto, Ontario, Canada M5G 2C4
    Endocrinology 147:3398-407. 2006
    ..The results suggest that activation of the UPR may significantly contribute to palmitate- but not oleate-induced pancreatic beta-cell death...
  16. ncbi Randomized double-blind study of the nutritional efficacy and bifidogenicity of a new infant formula containing partially hydrolyzed protein, a high beta-palmitic acid level, and nondigestible oligosaccharides
    Hansjörg Schmelzle
    Centre for Paediatric Medicine, University of Greifswald, Germany
    J Pediatr Gastroenterol Nutr 36:343-51. 2003
    ..the nutritional efficacy and bifidogenic characteristics of a new infant formula containing partially hydrolyzed whey protein, modified vegetable oil with a high beta-palmitic acid content, prebiotic oligosaccharides, and starch.
  17. doi Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes
    Matteo Ricchi
    Dipartimento Integrato di Medicina Interna, Endocrinologia, Metabolismo and Geriatria, Universita degli Studi di Modena e Reggio Emilia, Modena, Italy
    J Gastroenterol Hepatol 24:830-40. 2009
    Studies have shown monounsaturated oleic acid to be less toxic than palmitic acid and to prevent/attenuate palmitic acid hepatocites toxicity in steatosis models in vitro...
  18. pmc Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice
    Kouichi Miura
    Department of Medicine, University of California, San Diego, School of Medicine, La Jolla, CA, USA
    Hepatology 57:577-89. 2013
    ..Here we show that both TLR2 and palmitic acid are required for activation of the inflammasome, interleukin (IL)-1α, and IL-1β, resulting in the ..
  19. ncbi Toll-like receptor-2 is essential for the development of palmitate-induced insulin resistance in myotubes
    Joseph J Senn
    Department of Pediatrics, Charles P Darby Children s Research Institute, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Biol Chem 281:26865-75. 2006
    ..This study provides strong evidence that TLR2 mediates the initial events of fatty acid-induced insulin resistance in muscle...
  20. pmc Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability
    Dai Tian
    Department of Physiology and Pathophysiology, Shanghai Medical College, Fudan University, Shanghai, 200032, PR China
    Cardiovasc Diabetol 11:144. 2012
    ..However, the effect of StAR on endothelial dysfunction is not well understood. Palmitic acid (PA) has been shown to decrease eNOS activity and induce inflammation, both are the causes of endothelial ..
  21. doi Rosiglitazone counteracts palmitate-induced beta-cell dysfunction by suppression of MAP kinase, inducible nitric oxide synthase and caspase 3 activities
    S Meidute Abaraviciene
    Department of Clinical Science, Division of Endocrine Pharmacology, UMAS, CRC, 205 02, Malmo, Sweden
    Cell Mol Life Sci 65:2256-65. 2008
    ..We suggest that ROZ counteracts palmitateinduced deleterious effects on beta-cell function via suppression of iNOS, pro-apoptotic MAPKs and caspase-3 activities, as evidenced by restoration of glucose-stimulated insulin release...
  22. pmc Analysis of the networks controlling the antimicrobial-peptide-dependent induction of Klebsiella pneumoniae virulence factors
    Enrique Llobet
    Laboratory Microbial Pathogenesis, Fundació d Investigació Sanitària de les Illes Balears, Recinto Hospital Joan March, Carretera Soller km 12, 07110 Bunyola, Spain
    Infect Immun 79:3718-32. 2011
    ..Therapeutic strategies directed to prevent the activation of this program could be a new approach worth exploring to facilitate the clearance of the pathogen from the airways...
  23. doi Effects of palmitate on ER and cytosolic Ca2+ homeostasis in beta-cells
    Kamila S Gwiazda
    Laboratory of Molecular Signaling in Diabetes, Diabetes Research Group, Department of Cellular and Physiological Sciences, University of British Columbia, 5358 Life Sciences Bldg, 2350 Health Sciences Mall, Vancouver, BC, Canada, V6T 1Z3
    Am J Physiol Endocrinol Metab 296:E690-701. 2009
    ..We present the first direct evidence that free fatty acids reduce ER Ca2+ and shed light on pathways involved in lipotoxicity and the pathogenesis of type 2 diabetes...
  24. doi ROS-activated p38 MAPK/ERK-Akt cascade plays a central role in palmitic acid-stimulated hepatocyte proliferation
    Xin Wang
    Department of Toxicology, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi an, 710032, China
    Free Radic Biol Med 51:539-51. 2011
    ..b>Palmitic acid (PA) is the most prevalent saturated FFA in circulation...
  25. pmc Disruption of the FATB gene in Arabidopsis demonstrates an essential role of saturated fatty acids in plant growth
    Gustavo Bonaventure
    Department of Plant Biology, Michigan State University, East Lansing, Michigan 48824, USA
    Plant Cell 15:1020-33. 2003
    ....
  26. pmc Protection from palmitate-induced mitochondrial DNA damage prevents from mitochondrial oxidative stress, mitochondrial dysfunction, apoptosis, and impaired insulin signaling in rat L6 skeletal muscle cells
    Larysa V Yuzefovych
    Department of Cell Biology and Neuroscience, University of South Alabama, Mobile, Alabama 36688, USA
    Endocrinology 153:92-100. 2012
    ....
  27. ncbi Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    Francis Kim
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Circ Res 100:1589-96. 2007
    ....
  28. pmc Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae
    S P Srinivasa
    Department of Cell Biology and Physiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:5584-9. 1998
    ..Features of the N-terminal domain other than palmitoylation are responsible for the plasma membrane association of RGS4 and its ability to inhibit pheromone response in yeast...
  29. ncbi Mitochondrial dysfunction is involved in apoptosis induced by serum withdrawal and fatty acids in the beta-cell line INS-1
    Isabel Maestre
    Instituto de Bioingeniería Division of Nutrition, University Miguel Hernandez, San Juan, 03550 Alicante, Spain
    Endocrinology 144:335-45. 2003
    ....
  30. pmc Differential effects of palmitate and palmitoleate on insulin action and glucose utilization in rat L6 skeletal muscle cells
    Nikolaos Dimopoulos
    Division of Molecular Physiology, Centre for Interdisciplinary Research, Faculty of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Biochem J 399:473-81. 2006
    ....
  31. doi Macrophage migration inhibitory factor deficiency protects pancreatic islets from palmitic acid-induced apoptosis
    Tamara Saksida
    Department of Immunology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, Belgrade, Serbia
    Immunol Cell Biol 90:688-98. 2012
    ..HFD)-fed C57BL/6 mice and whether MIF inhibition could affect β-cell apoptosis and dysfunction induced by palmitic acid (PA) in vitro...
  32. doi Dietary fatty acids differentially regulate production of TNF-alpha and IL-10 by murine 3T3-L1 adipocytes
    Richard L Bradley
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    Obesity (Silver Spring) 16:938-44. 2008
    ..Effects on nuclear factor-kappaB (NF-kappaB), a key transcriptional activator of the inflammatory cascade, and suppressor of cytokine signaling 3 (SOCS-3), a negative regulator of cytokine signaling, were also determined...
  33. ncbi Palmitoylated proteins: purification and identification
    Junmei Wan
    Department of Pharmacology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Nat Protoc 2:1573-84. 2007
    ..MuDPIT also affords a semi-quantitative analysis that may be used to assess the gross changes induced to the global palmitoylation profile by mutation or drugs. Typically, 2-3 weeks are required for this analysis...
  34. ncbi Stearoyl-CoA desaturase-1 deficiency reduces ceramide synthesis by downregulating serine palmitoyltransferase and increasing beta-oxidation in skeletal muscle
    Agnieszka Dobrzyn
    Dept of Biochemistry, Univ of Wisconsin, 433 Babcock Dr, Madison, WI 53706, USA
    Am J Physiol Endocrinol Metab 288:E599-607. 2005
    ..Taken together, these results indicate that SCD1 deficiency reduces ceramide synthesis by decreasing SPT expression and increasing the rate of beta-oxidation in oxidative muscles...
  35. ncbi Palmitoylation: policing protein stability and traffic
    Maurine E Linder
    Department of Cell Biology and Physiology, Washington University School of Medicine, Box 8228, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Nat Rev Mol Cell Biol 8:74-84. 2007
    ..Here, we review recent studies that have provided insights into the mechanisms that mediate the functional consequences of this versatile modification...
  36. ncbi Palmitate induces tumor necrosis factor-alpha expression in C2C12 skeletal muscle cells by a mechanism involving protein kinase C and nuclear factor-kappaB activation
    Mireia Jové
    Pharmacology Unit, Department of Pharmacology and Therapeutic Chemistry, Faculty of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    Endocrinology 147:552-61. 2006
    ....
  37. ncbi What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 52:1641-8. 2003
    ....
  38. pmc MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    Andre Kleinridders
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD and Center of Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 10:249-59. 2009
    ..Thus, we define neuronal MyD88-dependent signaling as a key regulator of diet-induced leptin and insulin resistance in vivo...
  39. pmc Swf1-dependent palmitoylation of the SNARE Tlg1 prevents its ubiquitination and degradation
    Javier Valdez-Taubas
    MRC Laboratory of Molecular Biology, Cambridge, UK
    EMBO J 24:2524-32. 2005
    ..Our results suggest that one role of palmitoylation is to protect TMDs from the cellular quality control machinery, and that Swf1 may be the enzyme responsible for most, if not all, TMD-associated palmitoylation in yeast...
  40. pmc Palmitate inhibits insulin gene expression by altering PDX-1 nuclear localization and reducing MafA expression in isolated rat islets of Langerhans
    Derek K Hagman
    Pacific Northwest Research Institute, Seattle, Washington 98122, USA
    J Biol Chem 280:32413-8. 2005
    ..These results demonstrate that prolonged exposure of islets to palmitate inhibits insulin gene transcription by impairing nuclear localization of PDX-1 and cellular expression of MafA...
  41. doi Effects of pharmacological inhibition of NADPH oxidase or iNOS on pro-inflammatory cytokine, palmitic acid or H2O2-induced mouse islet or clonal pancreatic β-cell dysfunction
    Marta Michalska
    Department of Medical Biochemistry and Molecular Biology, University of Greifswald, D 17487 Greifswald, Germany
    Biosci Rep 30:445-53. 2010
    ..We investigated the effects of prolonged exposure (24 h) to pro-inflammatory cytokines, H(2)O(2) or PA (palmitic acid) on β-cell insulin secretion, ATP, the NADPH oxidase (nicotinamide adenine dinucleotide phosphate oxidase) ..
  42. pmc Activation of NF-kappaB by palmitate in endothelial cells: a key role for NADPH oxidase-derived superoxide in response to TLR4 activation
    Ezekiel Maloney
    Department of Medicine, University of Washington, Seattle, WA 98109, USA
    Arterioscler Thromb Vasc Biol 29:1370-5. 2009
    ..We investigated whether NADPH oxidase-dependent production of superoxide contributes to activation of NF-kappaB in endothelial cells by the saturated free fatty acid palmitate...
  43. doi Palm oil and palmitic acid: a review on cardiovascular effects and carcinogenicity
    Elena Fattore
    Department of Environmental Health Sciences, Mario Negri Institute for Pharmacological Research, Via Giuseppe La Masa 19, 20156 Milano, Italy
    Int J Food Sci Nutr 64:648-59. 2013
    ..with negative health effects is the relatively high content of saturated fatty acids (SFAs), particularly palmitic acid, which in turn have been associated with increased risk of coronary heart disease and some tumours...
  44. ncbi Fatty acid protection from palmitic acid-induced apoptosis is lost following PI3-kinase inhibition
    N Beeharry
    School of Pharmacy and Biomolecular Sciences, University of Brighton, Brighton, BN2 4GJ East Sussex, UK
    Apoptosis 9:599-607. 2004
    ..Co-incubation with inhibitors of ceramide synthesis, myriocin or fumonisin B(1), did not improve viability of palmitic acid treated RINm5F cells...
  45. pmc Ameliorative effects of polyunsaturated fatty acids against palmitic acid-induced insulin resistance in L6 skeletal muscle cells
    Keisuke Sawada
    Department of Agrobioscience, Graduate School of Agricultural Science, Kobe University, Kobe, Hyogo 657 8501, Japan
    Lipids Health Dis 11:36. 2012
    ..There is an increasing demand for compounds including drugs and functional foods that can prevent myocellular insulin resistance...
  46. ncbi Expression of the palmitoylation-deficient CD151 weakens the association of alpha 3 beta 1 integrin with the tetraspanin-enriched microdomains and affects integrin-dependent signaling
    Fedor Berditchevski
    Cancer Research UK Institute for Cancer Studies, The University of Birmingham, Edgbaston, Birmingham B15 2TA, United Kingdom
    J Biol Chem 277:36991-7000. 2002
    ..Our results demonstrate that palmitoylation of tetraspanins is critical not only for the organization of the integrin-tetraspanin microdomains but also has a specific role in modulation of adhesion-dependent signaling...
  47. pmc Palmitic acid acutely stimulates glucose uptake via activation of Akt and ERK1/2 in skeletal muscle cells
    Jing Pu
    National Laboratory of Biomacromolecules, Institute of Biophysics, Graduate University, Chinese Academy of Sciences, Beijing, 100101, China
    J Lipid Res 52:1319-27. 2011
    ..Taken together, our data suggest that PA-mediated glucose uptake in skeletal muscle cells may be stimulated by the binding of PA to cell surface and followed by PI3K/AMPK/Akt and PI3K/ERK1/2 pathways independently...
  48. pmc Acid sphingomyelinase plays a key role in palmitic acid-amplified inflammatory signaling triggered by lipopolysaccharide at low concentrations in macrophages
    Junfei Jin
    Ralph H Johnson Veterans Affairs Medical Center, Charleston, South Carolina
    Am J Physiol Endocrinol Metab 305:E853-67. 2013
    ..Since plasma free fatty acids (FAs) are elevated in obese patients and saturated FAs such as palmitic acid (PA) have been shown to increase host inflammatory response, we sought to find out how PA interacts with ..
  49. doi Palmitic acid in the sn-2 position of triacylglycerols acutely influences postprandial lipid metabolism
    Thomas A B Sanders
    Diabetes and Nutritional Sciences Division, School of Medicine, King s College London, United Kingdom
    Am J Clin Nutr 94:1433-41. 2011
    ..The triacylglycerol structure of saturated fats may influence postprandial lipemia...
  50. doi Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation
    Christopher M Mayer
    Department of Physiology, University of Toronto, Toronto, Ontario, Canada
    Endocrinology 151:576-85. 2010
    ..Thus, activation of AMP kinase prevents the deleterious effects of palmitate on hypothalamic neurons by inhibiting the onset of insulin resistance and apoptosis...
  51. doi Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways
    Hailong Jiang
    Department of Cardiology, Second Hospital Affiliated to the Second Military Medical University, 415 Fengyang Road, Shanghai 200003, People s Republic of China
    Atherosclerosis 210:71-7. 2010
    Recent studies have demonstrated that palmitic acid (PA) could regulate endothelial progenitor cells (EPCs) function (migration, proliferation, survival and angiogenesis) via various signal pathways, but the effect of PA on EPCs ..
  52. doi Protective role of autophagy in palmitate-induced INS-1 beta-cell death
    Sung E Choi
    Institute for Medical Science, Ajou University School of Medicine, Wonchon dong san5, Yongtong Gu, Suwon, Gyeonggi do 442 749, Republic of Korea
    Endocrinology 150:126-34. 2009
    ..These findings showed that the autophagy system could be activated in PA-treated INS-1 beta-cells, and suggested that the induction of autophagy might play an adaptive and protective role in PA-induced cell death...
  53. doi Palmitic and linoleic acids impair endothelial progenitor cells by inhibition of Akt/eNOS pathway
    Wei Xin Guo
    Department of Neurology, Xiangya Hospital of Central South University, Hunan Province, Changsha, China
    Arch Med Res 39:434-42. 2008
    ..This study was designed to investigate the association between Akt/eNOS signal pathway changes and the proliferation/function of EPCs in the presence of palmitic and linoleic acids...
  54. ncbi The influence of dietary palmitic acid triacylglyceride position on the fatty acid, calcium and magnesium contents of at term newborn faeces
    A Lopez-Lopez
    Departmento Nutrició i Bromatologia, Centre de Referència en Tecnologia dels Aliments, Facultat de Farmacia, Universitat de Barcelona, Avda Joan XXIII s n, 08028, Barcelona, Spain
    Early Hum Dev 65:S83-94. 2001
    ..In human milk, palmitic acid is predominantly esterified in the sn-2 position (beta-position) of the triglycerides, whereas in infant ..
  55. ncbi Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga
    Hideki Harada
    Marine and Highland Bioscience Center, Saga University, 152 1 Shonan cho, Karatsu, Saga 847 0021, Japan
    Anticancer Res 22:2587-90. 2002
    ..In this study, we identified palmitic acid, a selective cytotoxic substance from the marine algal extract, and investigated its biological activities...
  56. ncbi High levels of palmitic acid lead to insulin resistance due to changes in the level of phosphorylation of the insulin receptor and insulin receptor substrate-1
    Rosalia Reynoso
    Departamento de Bioquimica, Centro de Investigacion y de Estudios Avanzados del IPN, Mexico
    Mol Cell Biochem 246:155-62. 2003
    ..We evaluated several aspects of the insulin resistance induced by palmitic acid in rats and found that after treatment with 0...
  57. doi Preparation and evaluation of palmitic acid-conjugated exendin-4 with delayed absorption and prolonged circulation for longer hypoglycemia
    Juho Lee
    College of Pharmacy, Pusan National University, Jangjeon Dong, Geumjeong Gu, Busan, Republic of Korea
    Int J Pharm 424:50-7. 2012
    ..Here, exendin-4 was modified with palmitic acid, and the particle size and albumin-binding of palmitic acid-conjugated exendin-4 (Pal-Ex4) purified was ..
  58. pmc Preimplantation exposure of mouse embryos to palmitic acid results in fetal growth restriction followed by catch-up growth in the offspring
    Emily S Jungheim
    Department of Obstetrics and Gynecology, Washington University, St Louis, Missouri, USA
    Biol Reprod 85:678-83. 2011
    ..To address this knowledge gap, murine blastocysts were cultured in excess palmitic acid (PA), the most abundant saturated FFA in human serum, and ovarian follicular fluid...
  59. doi Cellular glutathione in fatty liver in vitro models
    Martha C Garcia
    FDA, Center for Food Safety and Applied Nutrition, Division of Toxicology, Laurel, MD 20708, United States
    Toxicol In Vitro 25:1501-6. 2011
    ..Cells cultured with palmitic acid (C16:0) or the combination oleic/palmitic acids (2:1 ratio) also exhibited a dose-dependent increase of GSH; ..
  60. pmc Palmitic acid induces osteoblastic differentiation in vascular smooth muscle cells through ACSL3 and NF-κB, novel targets of eicosapentaenoic acid
    Aiko Kageyama
    Development Research, Mochida Pharmaceutical Co, Ltd, Gotemba, Shizuoka, Japan
    PLoS ONE 8:e68197. 2013
    ..prevents the osteoblastic differentiation and mineralization of vascular smooth muscle cells (VSMC) induced by palmitic acid (PA), the most abundant long-chain saturated fatty acid in plasma...
  61. ncbi Disruption of endoplasmic reticulum structure and integrity in lipotoxic cell death
    Nica M Borradaile
    Center for Cardiovascular Research, Division of Cardiology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 47:2726-37. 2006
    ....
  62. ncbi Saturated free fatty acid, palmitic acid, induces apoptosis in fetal hepatocytes in culture
    Jun Ji
    Department of Central Laboratory, Dalian Municipal Central Hospital, Xuegong Street 42, Shahekou qu, Dalian 116033, China
    Exp Toxicol Pathol 56:369-76. 2005
    To investigate the effects of saturated free fatty acid, palmitic acid (PA), on hepatocytes, we administered PA to rat hepatocytes. We demonstrated that PA inhibited the cell growth as a dose- and time-dependent manner in rat hepatocytes...
  63. doi Palmitate induces C-reactive protein expression in human aortic endothelial cells. Relevance to fatty acid-induced endothelial dysfunction
    Yves Mugabo
    Centre Hospitalier de l Université de Montréal Research Centre, Notre Dame Hospital, Department of Medicine, Montreal, Quebec, Canada
    Metabolism 60:640-8. 2011
    ..They further support a role for endothelial cell-derived CRP as mediator of the suppressive effect of PA on NO production...
  64. doi Diets high in palmitic acid (16:0), lauric and myristic acids (12:0 + 14:0), or oleic acid (18:1) do not alter postprandial or fasting plasma homocysteine and inflammatory markers in healthy Malaysian adults
    Phooi Tee Voon
    Department of Nutrition and Dietetics, International Medical University, Kuala Lumpur, Malaysia
    Am J Clin Nutr 94:1451-7. 2011
    ..Dietary fat type is known to modulate the plasma lipid profile, but its effects on plasma homocysteine and inflammatory markers are unclear...
  65. pmc Palmitic acid mediates hypothalamic insulin resistance by altering PKC-theta subcellular localization in rodents
    Stephen C Benoit
    Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    J Clin Invest 119:2577-89. 2009
    ..regulate energy balance and whether it mediated the deleterious effects of diets high in fat, specifically palmitic acid, on hypothalamic insulin activity in rats and mice...
  66. doi Stearidonic acid soybean oil enriched with palmitic acid at the sn-2 position by enzymatic interesterification for use as human milk fat analogues
    Sarah A Teichert
    Department of Food Science and Technology, The University of Georgia, Athens, Georgia 30602 2610, United States
    J Agric Food Chem 59:5692-701. 2011
    ..Human milk fat has ≥60% of palmitic acid (PA), by weight, esterified at the sn-2 position to improve absorption of fat and calcium in infants...
  67. pmc Bamboo extract reduces interleukin 6 (IL-6) overproduction under lipotoxic conditions through inhibiting the activation of NF-κB and AP-1 pathways
    Jason K Higa
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii at Manoa, 651 Ilalo Street BSB 222, Honolulu, HI 96813, USA
    Cytokine 55:18-23. 2011
    ..b>Palmitic acid (PA, 0.4mM) was used to induce lipotoxicity in murine C2C12, 3T3-L1, and Hepa6 cells...
  68. pmc Increased expression of macrophage-inducible C-type lectin in adipose tissue of obese mice and humans
    Masayuki Ichioka
    Department of Molecular Medicine and Metabolism, Tokyo Medical and Dental University, Tokyo, Japan
    Diabetes 60:819-26. 2011
    ..The aim of this study was to identify the molecule(s) activated in adipose tissue macrophages in obesity...
  69. pmc An 11-bp insertion in Zea mays fatb reduces the palmitic acid content of fatty acids in maize grain
    Lin Li
    National Maize Improvement Center of China, China Agricultural University, Beijing, China
    PLoS ONE 6:e24699. 2011
    ..Here, we combine linkage and association analyses to fine map QTL-Pal9, a QTL influencing levels of palmitic acid, an important class of saturated fatty acid...
  70. doi Cyclooxygenase 2 inhibition exacerbates palmitate-induced inflammation and insulin resistance in skeletal muscle cells
    Teresa Coll
    Department of Pharmacology and Therapeutic Chemistry and Institut de Biomedicina de la Universitat de Barcelona, Faculty of Pharmacy, University of Barcelona, E 08028 Barcelona, Spain
    Endocrinology 151:537-48. 2010
    ..These findings indicate that COX-2 activity, through the production of PGE(2), attenuates the fatty acid-induced inflammatory process and insulin resistance...
  71. doi Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells
    Do Sung Kim
    Department of Pharmacology and Institute of Cardiovascular Research, School of Medicine, Chonbuk National University, Chonbuk, Republic of Korea
    Immunopharmacol Immunotoxicol 32:251-7. 2010
    ..These data may also provide a further rationale for exploring the use of metformin in the treatment of non-alcoholic fatty liver disease, revealing its blocking effect for hepatic insulin resistance evoked by saturated fatty acids...
  72. pmc Palmitate and insulin synergistically induce IL-6 expression in human monocytes
    Robert C Bunn
    Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Cardiovasc Diabetol 9:73. 2010
    ....
  73. pmc 2-Chlorohexadecanal and 2-chlorohexadecanoic acid induce COX-2 expression in human coronary artery endothelial cells
    Maria C Messner
    Department of Biochemistry and Molecular Biology, St Louis University Health Sciences Center, St Louis, MO 63104, USA
    Lipids 43:581-8. 2008
    ..These data suggest that 2-ClHDA and its metabolite 2-ClHA, which are produced during leukocyte activation, may alter vascular endothelial cell function by upregulation of COX-2 expression...
  74. doi Differential activation of ER stress and apoptosis in response to chronically elevated free fatty acids in pancreatic beta-cells
    Elida Lai
    Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, 101 College Street, TMOT 10 707, Toronto, ON, Canada, M5G1L7
    Am J Physiol Endocrinol Metab 294:E540-50. 2008
    ..Human islets and MIN6 cells were found to express high levels of stearoyl-CoA desaturase-1 compared with INS-1 cells, which may account for the decreased susceptibility of these cells to the cytotoxic effects of palmitate...
  75. doi Palmitic acid enhances lectin-like oxidized LDL receptor (LOX-1) expression and promotes uptake of oxidized LDL in macrophage cells
    Junichi Ishiyama
    Discovery Research Laboratories, Kyorin Pharmaceutical Co, Ltd, Shimotsuga gun, Tochigi, Japan
    Atherosclerosis 209:118-24. 2010
    ..Therefore, we examined whether NEFA could regulate expression of scavenger receptors responsible for uptake of oxidized LDL (oxLDL) in macrophages, a critical step in atherogenesis...
  76. doi A lipidomic screen of palmitate-treated MIN6 β-cells links sphingolipid metabolites with endoplasmic reticulum (ER) stress and impaired protein trafficking
    Ebru Boslem
    Diabetes and Obesity Program, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, NSW 2010, Australia
    Biochem J 435:267-76. 2011
    ..In conclusion, alterations in sphingolipid, rather than phospholipid, metabolism are more likely to be implicated in the defective protein trafficking and enhanced ER stress and apoptosis of lipotoxic β-cells...
  77. pmc Preparation and evaluation of ofloxacin-loaded palmitic acid solid lipid nanoparticles
    ShuYu Xie
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, China Agricultural University, Beijing, People s Republic of China
    Int J Nanomedicine 6:547-55. 2011
    ..Ofloxacin-loaded SLN were prepared using palmitic acid as lipid matrix and poly vinyl alcohol (PVA) as emulsifier by a hot homogenization and ultrasonication method...
  78. ncbi Differential stability of tetraspanin/tetraspanin interactions: role of palmitoylation
    Stephanie Charrin
    INSERM U268, Hopital Paul Brousse, 94807 Cedex, Villejuif, France
    FEBS Lett 516:139-44. 2002
    ..In particular, the resistance of the CD9/CD81 interaction to EDTA, which disrupts other tetraspanin/tetraspanin interactions, was entirely dependent on palmitoylation...
  79. pmc Use of analogs and inhibitors to study the functional significance of protein palmitoylation
    Marilyn D Resh
    Cell Biology Program, Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 143, New York, NY 10021, USA
    Methods 40:191-7. 2006
    ..Finally, general approaches to determining the effect of altered palmitoylation status on YFPP association with membranes and lipid rafts, as well as signal transduction, are described...
  80. ncbi A role for protein phosphatase 2A-like activity, but not atypical protein kinase Czeta, in the inhibition of protein kinase B/Akt and glycogen synthesis by palmitate
    R Cazzolli
    Garvan Institute of Medical Research, Sydney, Australia
    Diabetes 50:2210-8. 2001
    ..We conclude that palmitate disrupts insulin signaling in C2C12 myotubes by promoting PP2A-like activity and, therefore, the dephosphorylation of PKB, which in turn reduces the stimulation of glycogen synthesis...
  81. ncbi Expression profiling of palmitate- and oleate-regulated genes provides novel insights into the effects of chronic lipid exposure on pancreatic beta-cell function
    Anna K Busch
    Garvan Institute of Medical Research, St Vincent s Hospital, Sydney, Australia
    Diabetes 51:977-87. 2002
    ..The results highlight links between regulated gene expression and phenotypic alterations in palmitate versus oleate-pretreated beta-cells...
  82. ncbi Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization
    K Kraft
    Department of Immunology, University of Gottingen, 37075 Gottingen, Germany
    J Biol Chem 276:34408-18. 2001
    ..Together these results indicate that post-translational modifications of carboxyl-terminal serine and cysteine residues have a significant impact on receptor deactivation and internalization...
  83. ncbi Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras
    Tara L Baker
    Department of Zoology Genetics, Iowa State University, Ames, Iowa 50011, USA
    J Biol Chem 278:19292-300. 2003
    ..This previously undetected difference could help produce distinctive effector interactions and signaling of oncogenic H-Ras...
  84. ncbi Caveolin is palmitoylated on multiple cysteine residues. Palmitoylation is not necessary for localization of caveolin to caveolae
    D J Dietzen
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110
    J Biol Chem 270:6838-42. 1995
    ..Thus, palmitoylation of cysteine residues in nonmembrane spanning Src family protein tyrosine kinases has different consequences than in the transmembrane protein caveolin...
  85. ncbi Free fatty acid impairment of nitric oxide production in endothelial cells is mediated by IKKbeta
    Francis Kim
    Department of Medicine, Division of Cardiology, University of Washington, Harborview Medical Center, Seattle, Wash 98104, USA
    Arterioscler Thromb Vasc Biol 25:989-94. 2005
    ..Insulin receptor substrate-1 (IRS-1) regulation is critical for activation of endothelial nitric oxide synthase (eNOS) in response to stimulation by insulin or fluid shear stress...
  86. ncbi Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes
    Thomas A Miller
    Molecular Stress Response Unit, Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, MA 02118, USA
    Biochem Biophys Res Commun 336:309-15. 2005
    ..These results support a model for palmitate-induced apoptosis, activation of SAPKs, and protein oxidative stress in myocytes that involves cytosolic accumulation of saturated fatty acids...
  87. ncbi Hydrogen peroxide and hydroxyl radicals mediate palmitate-induced cytotoxicity to hepatoma cells: relation to mitochondrial permeability transition
    Shireesh Srivastava
    Department of Chemical Engineering and Materials Science, Michigan State University, East Lansing, MI 48824, USA
    Free Radic Res 41:38-49. 2007
    ..These results suggest that palmitate-cytotoxicity to hepatoma cells is mediated through the production of H2O2 and *OH and independent of MPT...
  88. ncbi Palmitoylation of phospholipid scramblase 1 controls its distribution between nucleus and plasma membrane
    Therese Wiedmer
    Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 42:1227-33. 2003
    ..These data suggest that under the circumstance of rapid biosynthesis in response to gene induction by cytokines, PLSCR1 traffics into the nucleus, implying a potential nuclear function for this protein...
  89. ncbi Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation
    M Cnop
    Diabetes Research Center, Vrije Universiteit Brussel, Brussels, Belgium
    Diabetes 50:1771-7. 2001
    ..It is conceivable that this potential is lost or insufficient in cells with a prolonged triglyceride accumulation as may occur in vivo...
  90. ncbi Monounsaturated fatty acids prevent the deleterious effects of palmitate and high glucose on human pancreatic beta-cell turnover and function
    Kathrin Maedler
    Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, CH 8091 Zurich, Switzerland
    Diabetes 52:726-33. 2003
    ..Moreover, each monounsaturated fatty acid prevented the deleterious effects of both palmitic acid and high glucose concentration...
  91. pmc Involvement of astroglial ceramide in palmitic acid-induced Alzheimer-like changes in primary neurons
    Sachin Patil
    Department of Chemical Engineering and Material Science, Michigan State University, East Lansing, MI 48824, USA
    Eur J Neurosci 26:2131-41. 2007
    ..We found that palmitic acid significantly increased de-novo synthesis of ceramide in astroglia, which in turn was involved in inducing ..
  92. pmc Linking endoplasmic reticulum stress to cell death in hepatocytes: roles of C/EBP homologous protein and chemical chaperones in palmitate-mediated cell death
    Kyle T Pfaffenbach
    Colorado State University, Department of Food Science and Human Nutrition, Gifford 234, Fort Collins, CO 80523 1571, USA
    Am J Physiol Endocrinol Metab 298:E1027-35. 2010
    ..These data suggest that ER stress is linked to palmitate-mediated cell death via mechanisms that include JNK activation...
  93. ncbi Distinct effects of saturated and monounsaturated fatty acids on beta-cell turnover and function
    K Maedler
    Division of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland
    Diabetes 50:69-76. 2001
    ..Exposure of islets to saturated fatty acid (0.5 mmol/l palmitic acid) in medium containing 5.5, 11.1, or 33...
  94. pmc CHOP and AP-1 cooperatively mediate PUMA expression during lipoapoptosis
    Sophie C Cazanave
    Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Physiol Gastrointest Liver Physiol 299:G236-43. 2010
    ..Finally, loss of function studies suggest that both transcription factors are necessary for maximal PUMA induction. Collectively, these data suggest that CHOP and AP-1 cooperatively mediate PUMA induction during hepatocyte lipoapoptosis...
  95. ncbi High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C--dependent activation of NAD(P)H oxidase in cultured vascular cells
    T Inoguchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushyu University, Fukuoka, Japan
    Diabetes 49:1939-45. 2000
    ..This finding may be involved in the excessive acceleration of atherosclerosis in patients with diabetes and insulin resistance syndrome...
  96. ncbi Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate
    B Ritz-Laser
    Clinical Diabetology, Centre Medical Universitaire, Geneva, Switzerland
    Endocrinology 140:4005-14. 1999
    ....
  97. pmc Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone
    Leanne Wilson-Fritch
    Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, 01601, USA
    J Clin Invest 114:1281-9. 2004
    ....
  98. doi Modulation of palmitate-induced endoplasmic reticulum stress and apoptosis in pancreatic β-cells by stearoyl-CoA desaturase and Elovl6
    Christopher D Green
    Dept of Physiology, Michigan State University, East Lansing, 48824 3320, USA
    Am J Physiol Endocrinol Metab 300:E640-9. 2011
    ..Overt type 2 diabetes is associated with diminished islet expression of SCD and Elovl6, and this can disrupt desaturation of saturated FAs to MUFAs, rendering β-cells more susceptible to saturated FA-induced ER stress and apoptosis...
  99. ncbi Functional domains in tetraspanin proteins
    Christopher S Stipp
    Dana Farber Cancer Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA
    Trends Biochem Sci 28:106-12. 2003
    ....
  100. ncbi Effects of palmitate on Ca(2+) handling in adult control and ob/ob cardiomyocytes: impact of mitochondrial reactive oxygen species
    Jeremy Fauconnier
    Department of Physiology and Pharmacology, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Diabetes 56:1136-42. 2007
    ..Conversely, high fatty acid levels may be vital to sustain cardiac Ca(2+) handling and contraction in obesity and insulin-resistant conditions...
  101. doi Resveratrol inhibits the expression of SREBP1 in cell model of steatosis via Sirt1-FOXO1 signaling pathway
    Guang Li Wang
    Department of Lemology, The First Affiliated Hospital of Shantou University Medical College, 57 Changping Road, Shantou 515041, PR China
    Biochem Biophys Res Commun 380:644-9. 2009
    ..Our results suggest that resveratrol may attenuate fat deposition by inhibiting SREBP1 expression via Sirt1-FOXO1 pathway and thus may have application for the treatment of NAFLD...

Research Grants75

  1. Role of Perilipin in Hepatic Steatosis and Metabolism
    Thomas A Bowman; Fiscal Year: 2013
    ..These hepatocytes will be incubated with oleic and/or palmitic acid to mimic in vivo trafficking of fatty acids to the liver and facilitate TAG accumulation...
  2. T Cells, Macrophages, Chemokines, and Adiposopathy in Diet-Induced Obesity
    CHRISTIE MITCHELL BALLANTYNE; Fiscal Year: 2013
    ..b>Palmitic acid, a long-chain SFA present in high concentration in the HF diet, increases MCP-1 and RANTES expression in ..
  3. Palmitate Metabolism and Insulin Resistance
    CRAIG LAWRENCE KIEN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Palmitic acid (PA), impairs insulin sensitivity in skeletal muscle, and replacing PA in the diet with oleic acid (OA), a monounsaturated fatty acid (FA), may be beneficial...
  4. Mechanisms underlying metabolic syndrome in obesity
    Charlotte A Peterson; Fiscal Year: 2013
    ..Furthermore, the presence of macrophages in co-culture with muscle cells, in the presence of palmitic acid to mimic an obese environment, results in a synergistic increase in the expression and secretion of ..
  5. Palmitic Acid Regulation of Dendritic Cell Toll-Like Receptor 4 Signaling
    DEQUINA ANGELINA NICHOLAS; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Dietary saturated fatty acids (FAs), such as palmitic acid (PA), play a major role in inflammation- associated disease...
  6. Mechanisms of Liver Inflammation
    Harmeet Malhi; Fiscal Year: 2013
    ..In preliminary experiments we have observed that macrophages are activated upon treatment with palmitic acid (PA);we have termed this phenomenon lipoactivation...
  7. Dopamine Transporter Palmitoylation
    JAMES DARREN FOSTER; Fiscal Year: 2011
    ..recently discovered that rat, mouse, and human DATs are modified by palmitoylation, the covalent attachment of palmitic acid. This is the first demonstration of lipid modification for DAT or related neurotransmitter transporters, and ..
  8. DGAT1: Linking Fatty Acids to Inflammation and Metabolism in White Adipose Tissue
    SUNEIL KRISHNA KOLIWAD; Fiscal Year: 2013
    ..expression in macrophages correlated directly with TG storage and inversely with M1 activation by saturated palmitic acid. I thus completed Subaims 2.1, 2.3, and part of 2...
  9. Saturated Fatty Acid and Cardiovascular Disease
    Eric J Smart; Fiscal Year: 2010
    ..e., myristic acid and palmitic acid) are considered to be pro-atherogenic...
  10. OMEGA-3 FATTY ACIDS & HEPATIC LIPID METABOLISM
    David Otto; Fiscal Year: 1990
    ..1) Initial experiments will compare the utilization and short-term metabolic effects of palmitic acid, linoleic acid, eicosapentaenoic acid (C20:5 omega- 3), and docosahexaenoic acid (C22:6 omega-3) in isolated ..
  11. DIETARY N 3 FATTY ACIDS AND EXPRESSION OF CYCLOOXYGENASE
    Daniel Hwang; Fiscal Year: 2002
    ..3) To determine whether Lyn and Ras are acylated by fatty acids other than palmitic acid and whether the palmitoylation of Lyn and Ras is altered by n-3 PUFAs...
  12. REGULATION OF HEPATIC PRODUCTION AND UPTAKE OF GLUCOSE
    Stanley Blumenthal; Fiscal Year: 1980
    ..on gluconeogenesis in liver - and to determine whether octanoic acid alters the gluconeogenic response to palmitic acid. We will also reexamine the relationship between intrahepatic acetyl CoA levels and gluconeogenesis, ..
  13. ASSESSING MUCOSAL SURFACE AREA IN CELIAC DISEASE
    Morteza Janghorbani; Fiscal Year: 2000
    ..Thus, we propose to develop a method for accurate and noninvasive measurement of absorption of a dose of 13C-palmitic acid ingested under standard test conditions by the celiac patients...
  14. PALMITOYLATION OF THE U OPIOID RECEPTOR
    Lee Yuan Liu Chen; Fiscal Year: 1999
    ..1) To determine whether the mu opioid receptor is palmitoylated by assessing the incorporation of [3H]palmitic acid into the mu receptor and to examine the effect of agonist exposure on palmitoylation and de-palmitoylation; (2)..
  15. LUNG SPECIFIC DELIVERY OF OLIGONUCLEOTIDES
    Jeffrey Hughes; Fiscal Year: 1999
    ..To overcome the mycobacterium cell wall, a palmitic acid oligonucleotide conjugate will be evaluated in a model in vitro test system.
  16. PET RADIOPHARMACEUTICALS FOR CARDIAC AND OTHER STUDIES
    Michael Welch; Fiscal Year: 2002
    ..Four sub-projects are proposed and include: 1) the synthesis of palmitic acid labeled in the carboxyl, omega and omega-1 positions, which will be evaluated in a transgenic mouse model to ..
  17. Development of System for Treatment of Tuberculosis
    Takuji Tsukamoto; Fiscal Year: 2001
    ..tuberculosis cell envelope. Our specific aims are: 1. To synthesize and characterize palmitic acid derivatives of isoniazid and rifampin. 2...
  18. Characterization of Lck and Associated Proteins
    MARIETTA HARRISON; Fiscal Year: 2006
    ..Using mutant versions of Lck and structural analogs of palmitic acid and farnesol designed to either target Lck, LAT (critical adaptor protein) and Ras (a key member of the Ras ..
  19. Estrogen, fatty acyl CoA, & NOS function in hypertension
    MARGARET WEIS; Fiscal Year: 2003
    ..Recently, we identified a long chain fatty acyl CoA synthetase that prefers palmitic acid and is highly expressed in the vascular endothelium (eLCFACoAS)...
  20. TUMOR PROMOTER INDUCED PROTEIN PHOSPHORYLATION
    Eileen Friedman; Fiscal Year: 1992
    ..Fecal diglycerides (DGs), composed of oleic, myristic, or palmitic acid residues, were found in vivo at uM to mM concentrations (Cancer Res...
  21. The Role of Ceramide in Diabetic Retinopathy
    Mark Kester; Fiscal Year: 2006
    ..preliminary data suggest that C16-ceramide selectively accumulates in diabetic retinas, a possible result of palmitic acid-induced de novo synthesis...
  22. DEVELOPMENT OF NEW P.E.T. RADIOPHARMACEUTICALS
    Michael Welch; Fiscal Year: 1992
    ..The synthesis of O-15 labeled DOPA. 2. New approaches of omega-labeling of compounds, particularly palmitic acid. 3. Approaches to synthesizing an improved marker of hypoxic tissue. 4...
  23. DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS
    CRAIG KIEN; Fiscal Year: 2003
    ..Preliminary data indicate that the rate of oleic acid oxidation is 21 percent increased compared to palmitic acid. If the ratio of OA to PA in the diet were to increase, the rate of total fatty acid oxidation in the fed ..
  24. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    Project Summary: Preliminary Data in young, non-obese, human subjects suggest that increasing dietary palmitic acid (PA) lowers daily non-resting energy expenditure, blunts the usual post-exercise rise in energy expenditure, and lowers ..
  25. Colonic Bacterial Synthesis of Butyric Acid
    CRAIG KIEN; Fiscal Year: 2004
    ....
  26. STRUCTURE AND FUNCTION OF HIV GAG PROTEIN
    MARILYN RESH; Fiscal Year: 2009
    ..Multicolor imaging with site-specific fluorescein derivatives (FLASH and ReAsH) will be used to determine the order in which Gag assembly sites are formed and maintained in the cell. ..
  27. INSULIN RECEPTOR SUBSTRATE -1 AND FLUID SHEAR STRESS
    Francis Kim; Fiscal Year: 2005
    ..To further characterize this potential link between insulin and NO signaling. Specific Aim 3: Characterize FSS dependent signaling elements which associate with IRS-1...
  28. IKKBeta Mediated Impairment of Endothelial Nitric Oxide Production
    Francis Kim; Fiscal Year: 2010
    ..Aim 3. To determine whether the Toll Like Receptor pathway is necessary for endothelial activation of IKKbeta during the development of vascular insulin resistance. ..
  29. Glial cell differentiation and glioma formation
    MARILYN RESH; Fiscal Year: 2006
    ..The activity of the above proteins in human glioma tumor samples will be determined. ..
  30. DIETS FOR DYSLIPIDEMIA IN THE METABOLIC SYNDROME
    Robert Knopp; Fiscal Year: 2009
    ..This study will be the first to demonstrate dietary benefit for dyslipidemia, inflammation and vascular stress in MetS at stable weight. ..
  31. The Mechanism and Significance of Evf ncRNA regulation of the Dix genes
    JHUMKU DUTT KOHTZ; Fiscal Year: 2010
    ..These include: Prader Willi Syndrome, diGeorge Syndrome, Beckwith-Wiedeman syndrome, Spinocerebellar ataxia type 8, and campomelic dysplasia. ..
  32. Factors Influencing Shh Signaling in the Forebrain
    JHUMKU KOHTZ; Fiscal Year: 2007
    ..abstract_text> ..
  33. The role of cardiolipin apoptosis
    DIANE HICKSON BICK; Fiscal Year: 2007
    ..The role of these modified phospholipids in cyt c release will be determined. We will answer the question "is the loss of cyt c preceded by deacylation of CL?" [unreadable] [unreadable]..
  34. Structural Immunology of CD1 and CD1-TCR Complexes
    Dirk Zajonc; Fiscal Year: 2008
    ..Structural insights into the differences of self vs. microbial antigen presentation will help understand the role of microbial lipids and lipid-reactive T cells in host defense and autoimmune diseases. ..
  35. Gene Polymorphisms, Preterm Birth, Neonatal Complicatio*
    Steven Witkin; Fiscal Year: 2005
    ..Identification of genetic factors in mothers or their neonates that influence susceptibility to preterm labor and fetal morbidity in different racial groups will aid in development of improved protocols for monitoring and treatment...
  36. Gene delivery to striated muscle by systemic AAV vectors
    Dwight D Koeberl; Fiscal Year: 2010
    ..Efficacious muscle-targeted gene therapy in GSD-II will have implications for gene therapy in other muscular dystrophies and myopathies. ..
  37. Signaling Diversity Among Gqa Family Members
    JOHN HEPLER; Fiscal Year: 2004
    ..Information gained from these studies will help us to better understand G proteins as therapeutic targets. ..
  38. Regulation of Microdomain Structure in Living Cells
    Anne K Kenworthy; Fiscal Year: 2010
    ..These studies will also contribute to our long- term goal of understanding how membrane structure regulates cellular functions. ..
  39. NUTRITION ACADEMIC AWARD
    Robert Knopp; Fiscal Year: 2002
    ..It is time to begin aggressive, substantive nutrition educational programs in cardiovascular disease prevention. ..
  40. A cell-free system for exocytosis in the beta-cell
    SUSANNE STRAUB SHARP; Fiscal Year: 2005
    ..physiological mechanisms such as time-dependent potentiation and biphasic insulin release. The method will also allow the study of some aspects of endocytosis. ..
  41. High Resolution Digital Camera for TEM.
    Bridget Wilson; Fiscal Year: 2006
    ..The new camera will ensure the continued productivity of NIH-funded electron microscopy-based research programs in cellular and molecular biology and neurosciences at the University of New Mexico. [unreadable] [unreadable]..
  42. HUMAN P450 ENZYMES AND THEIR TOXICOLOGICAL IMPACT
    Judy Raucy; Fiscal Year: 2003
    ....
  43. ROLE OF PROTEIN PHOSPHATASES IN INSULIN SECRETION
    Anjaneyulu Kowluru; Fiscal Year: 2004
    ....
  44. Cryptosporidium parvum DNA replication proteins
    Guan Zhu; Fiscal Year: 2004
    ..The completion of these aims will not only prove or refute our hypothesis, but also establish a new foundation for the drug discovery targeting the parasite unique DNA mechanism machinery. ..
  45. Interaction of HSV-1 LAT Gene & Dendritic Cells Function
    Lbachir BenMohamed; Fiscal Year: 2004
    ..a)Determine if LAT modulates cytokine and chemokine secretion by DC and chemokine-receptor expression on DC, all of which are involved in migratory activity of DC. (b)Determine if LAT changes the observed migratory activity of DC. ..
  46. Fatty Acid Biosynthesis in Cryptosporidium parvum
    Guan Zhu; Fiscal Year: 2010
    ..3) To validate that fatty acid metabolic enzymes may serve as rational drug target in Cryptosporidium by discovering inhibitors selectively against, parasite fatty acid metabolic enzymes. ..
  47. LIPID METABOLISM IN FAT CELLS
    Wen Guo; Fiscal Year: 2010
    ..Together, these studies will provide new insights into the stress-induced regulation of lipogenesis in adipocytes, a potentially important avenue for modulating energy balance. ..
  48. Use of GIS in analyzing environmental cancer risks as a*
    Robin Harris; Fiscal Year: 2003
    ..abstract_text> ..
  49. Protein Prenyltransferases in Glucose-Stimulated Insulin Secretion
    Anjaneyulu Kowluru; Fiscal Year: 2010
    ....
  50. Mechanisms for immune tolerance in Pompe Disease
    Dwight D Koeberl; Fiscal Year: 2010
    ..These comparisons will guide preclinical experiments to further immunomodulatory gene therapy in Pompe disease and other lysosomal storage disorders. ..
  51. MEMBRANE MECHANISMS MEDIATING ALCOHOL INDUCED PATHOLOGY
    Richard Gross; Fiscal Year: 2001
    ..Collectively, the proposed research represents a multidisciplinary approach designed to dissect the biochemical mechanisms underlying these novel effects of ethanol and ethanol metabolites on hippocampal function. ..
  52. NMR AND MR IMAGING STUDIES OF PLAQUE RUPTURE
    James Hamilton; Fiscal Year: 2003
    ..Because the ultrastructure of plaques appears to be key to their stability and potential for regression, MR imaging has the potential for being a more reliable predictor of acute pathological events (heart attack and stroke). ..
  53. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..abstract_text> ..
  54. HUMAN LIVER CYTOCHROMES P450
    Judy Raucy; Fiscal Year: 2002
    ..abstract_text> ..
  55. Infrastructure equipment for gene expression analysis
    Sorin Draghici; Fiscal Year: 2003
    ..Furthermore, the system may be expanded in the future, to accommodate new investigators at a cost that is very feasible. ..
  56. MAGNETIC RESONANCE CARDIAC C13FLUX AND METABOLIC RATE
    E Lewandowski; Fiscal Year: 2001
    ..The long range objective is the ultimate use of C13 NMR to assess the activity and expression of these mitochondrial proteins that regulate metabolic flux in intact and in vivo organs during development and disease. ..
  57. Exercise Substrate Utilization:The Crossover Concept
    George Brooks; Fiscal Year: 2006
    ..Further, we have the auxiliary personnel and facilities to conduct longitudinal training studies ..
  58. Metabolism of Hypertrophic Hearts Overexpressing SERCA
    J O DONNELL; Fiscal Year: 2009
    ..Our long term goal is: to identify the specific mechanisms of metabolic uncoupling in hypertrophic heart as potential targets for therapeutic intervention. ..
  59. GENE KNOCK-OUT MICE AS MODELS FOR THE LEPROSY SPECTRUM
    Linda Adams; Fiscal Year: 2006
    ..leprae in targeted gene KO mice an ideal model for analyzing the principal redundant and compensatory mechanisms of CMI in host resistance to infection in general and to intracellular mycobacterial pathogens in particular. ..
  60. Metabolic enzyme activity mediating myocardial stunning
    E Lewandowski; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  61. Assay Development to Identifiy Palmitoylation Inhibitors of Neuronal Proteins
    Maurine Linder; Fiscal Year: 2006
    ....
  62. Molecular and Cellular Mechanisms of Glaucoma
    OLEG KISSELEV; Fiscal Year: 2007
    ..abstract_text> ..
  63. Regulation of Mammalian Oocyte Maturation
    Stephen Downs; Fiscal Year: 2007
    ..Furthermore, these studies will benefit the development of in vitro systems where either meiotic arrest or completion of meiotic maturation is the desired endpoint. ..
  64. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  65. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  66. HIV Protease Inhibitors: Insulin Resistance & Insulysin
    FREDERICK HAMEL; Fiscal Year: 2007
    ..If insulin-degrading enzyme is involved, HIV protease inhibitors could be developed or screened for minimal reactivity with IDE. ..
  67. Novel algorithms and organisms for Onto-Tools
    Sorin Draghici; Fiscal Year: 2007
    ..The enhanced Onto-Tools will continue to be freely available. Onto-Analyzer and the software evolution tools developed under this proposal will be made freely available to the research community, as well. ..
  68. Role of bamboo extract in relieving lipotoxicity and oxidative stress in diabetes
    Jun Panee; Fiscal Year: 2007
    ....
  69. New Mechanisms in the Pathogenesis of Diabetic Nephropathy
    Rama Natarajan; Fiscal Year: 2008
    ..They could also pave the way for novel new therapies for various complications of diabetes including nephropathy. [unreadable] [unreadable] [unreadable]..
  70. Metabolic Abnormalities in HIV
    Dominic Reeds; Fiscal Year: 2008
    ..abstract_text> ..
  71. Membrane Targeting of G Proteins
    Philip Wedegaertner; Fiscal Year: 2007
    ..abstract_text> ..
  72. Mechanisms of Energy Balance in the Adipocyte
    Richard Bradley; Fiscal Year: 2005
    ..abstract_text> ..
  73. DIETARY FAT REGULATION OF HEPATIC GENE EXPRESSION
    DONALD JUMP; Fiscal Year: 2009
    ..Determine how over expression of specific fatty acid elongases affects hepatic function, blood lipid composition and the onset of chronic disease. ..