octanols

Summary

Summary: Isomeric forms and derivatives of octanol (C8H17OH).

Top Publications

  1. pmc Experimental measures of amino acid hydrophobicity and the topology of transmembrane and globular proteins
    Richard Wolfenden
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Gen Physiol 129:357-62. 2007
  2. ncbi Modeling of flux through silicone membranes from water
    Scott Wasdo
    Department of Medicinal Chemistry, University of Florida, P O Box 100485, Gainesville, FL 32610, USA
    Eur J Pharm Sci 34:321-32. 2008
  3. ncbi Effects of gap junction blockers on human neocortical synchronization
    S Gigout
    INSERM U 573, Paris, 75014 France
    Neurobiol Dis 22:496-508. 2006
  4. pmc Insect repellents: modulators of mosquito odorant receptor activity
    Jonathan D Bohbot
    Invasive Insect Biocontrol and Behavior Laboratory, Henry A Wallace Beltsville Agricultural Research Center, Plant Sciences Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland, United States of America
    PLoS ONE 5:e12138. 2010
  5. ncbi Lipid nanoemulsions loaded with doxorubicin-oleic acid ionic complex: characterization, in vitro and in vivo studies
    Xuanmiao Zhang
    Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, P R China
    Pharmazie 66:496-505. 2011
  6. ncbi NMR analysis of ion pair formation between timolol and sorbic acid in ophthalmic preparations
    Masayo Higashiyama
    Senju Pharmaceutical Co Ltd, 1 5 4 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Pharm Biomed Anal 43:1335-42. 2007
  7. ncbi Prolonged epileptiform bursting induced by 0-Mg(2+) in rat hippocampal slices depends on gap junctional coupling
    R Kohling
    Division of Neuroscience Neurophysiology, The Medical School, University of Birmingham, UK
    Neuroscience 105:579-87. 2001
  8. ncbi Odor-active compounds of Iberian hams with different aroma characteristics
    Ana I Carrapiso
    Laboratory of Food Technology, University of Extremadura, 10071 Caceres, Spain
    J Agric Food Chem 50:6453-8. 2002
  9. ncbi Field evaluation of CDC and Mosquito Magnet X traps baited with dry ice, CO2 sachet, and octenol against mosquitoes
    Rui De Xue
    Anastasia Mosquito Control District, 500 Old Beach Road, St Augustine, FL 32080, USA
    J Am Mosq Control Assoc 24:249-52. 2008
  10. ncbi Octenol as attractant to Nyssomyia neivai (Diptera:Psychodidae:Phlebotominae) in the field
    M C Pinto
    Laboratorio de Parasitologia, Departamento de Ciencias Biologicas, Faculdade de Ciencias Farmaceuticas, Universidade Estadual Julio de Mesquita Filho, 14801 902 Araraquara SP, Brazil
    J Med Entomol 48:39-44. 2011

Research Grants

  1. FLUID BILAYER INTERACTIONS WITH PEPTIDES
    Stephen White; Fiscal Year: 2004
  2. HSV-2 and Down-Regulations of Gap Junctions
    RICHARD WOODRUFF; Fiscal Year: 2003
  3. Neuromuscular synaptogenesis in zebrafish
    Rita Balice Gordon; Fiscal Year: 2004
  4. Genetic approaches to neurotrophin signaling
    Rita Balice Gordon; Fiscal Year: 2006
  5. Integrated Protein Surface Annotation Suite
    Maxim Totrov; Fiscal Year: 2006
  6. Genetics of neuromuscular synaptogenesis in zebrafish
    Rita Balice Gordon; Fiscal Year: 2008
  7. Identification of Alcohol Binding Site(s) in Protein Kinase C Epsilon
    Joydip Das; Fiscal Year: 2007
  8. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
  9. Volatile Anesthesia and the GABAA Receptor Gamma Subunit
    Stuart Forman; Fiscal Year: 2009
  10. Cold Neutrons For Biology And Technology
    Stephen White; Fiscal Year: 2005

Detail Information

Publications213 found, 100 shown here

  1. pmc Experimental measures of amino acid hydrophobicity and the topology of transmembrane and globular proteins
    Richard Wolfenden
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    J Gen Physiol 129:357-62. 2007
  2. ncbi Modeling of flux through silicone membranes from water
    Scott Wasdo
    Department of Medicinal Chemistry, University of Florida, P O Box 100485, Gainesville, FL 32610, USA
    Eur J Pharm Sci 34:321-32. 2008
    ..Thus, data for J(MPAQ) can be fitted to the RS equation, which also provides the best fit to maximum flux from water through mouse or human skin and includes a dependence on S(AQ)...
  3. ncbi Effects of gap junction blockers on human neocortical synchronization
    S Gigout
    INSERM U 573, Paris, 75014 France
    Neurobiol Dis 22:496-508. 2006
    ..These data indicate that GJ play a role in synchronizing human neocortical networks and may implement epileptiform activity in FCD...
  4. pmc Insect repellents: modulators of mosquito odorant receptor activity
    Jonathan D Bohbot
    Invasive Insect Biocontrol and Behavior Laboratory, Henry A Wallace Beltsville Agricultural Research Center, Plant Sciences Institute, Agricultural Research Service, United States Department of Agriculture, Beltsville, Maryland, United States of America
    PLoS ONE 5:e12138. 2010
    ....
  5. ncbi Lipid nanoemulsions loaded with doxorubicin-oleic acid ionic complex: characterization, in vitro and in vivo studies
    Xuanmiao Zhang
    Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Sichuan, P R China
    Pharmazie 66:496-505. 2011
    ..Moreover, DOX-OA-LNs significantly decreased DOX concentration in heart, lung and kidney. These results suggested that DOX-OA-LNs could be a promising formulation for the delivery of DOX in tumor chemotherapy...
  6. ncbi NMR analysis of ion pair formation between timolol and sorbic acid in ophthalmic preparations
    Masayo Higashiyama
    Senju Pharmaceutical Co Ltd, 1 5 4 Murotani, Nishi ku, Kobe 651 2241, Japan
    J Pharm Biomed Anal 43:1335-42. 2007
    ..Our analysis using NMR spectroscopy should advance the understanding and optimization of formulations that are based on ion pair...
  7. ncbi Prolonged epileptiform bursting induced by 0-Mg(2+) in rat hippocampal slices depends on gap junctional coupling
    R Kohling
    Division of Neuroscience Neurophysiology, The Medical School, University of Birmingham, UK
    Neuroscience 105:579-87. 2001
    ..Surgically isolating the CA3 subfield made secondary discharges disappear, and trimethylamine under these conditions was able to restore them.We conclude that gap junctions can contribute to the prolongation of epileptiform discharges...
  8. ncbi Odor-active compounds of Iberian hams with different aroma characteristics
    Ana I Carrapiso
    Laboratory of Food Technology, University of Extremadura, 10071 Caceres, Spain
    J Agric Food Chem 50:6453-8. 2002
    ..Otherwise, the largest scores for moldy aroma in long-Montanera hams matched with the largest detection frequency of 1-octen-3-one and 1-octen-3-ol in this group...
  9. ncbi Field evaluation of CDC and Mosquito Magnet X traps baited with dry ice, CO2 sachet, and octenol against mosquitoes
    Rui De Xue
    Anastasia Mosquito Control District, 500 Old Beach Road, St Augustine, FL 32080, USA
    J Am Mosq Control Assoc 24:249-52. 2008
    ..The CDC traps baited with fresh sachets and 24-h-exposed sachets collected significantly more mosquitoes than the traps baited with 48-h- and 72-h-exposed sachets...
  10. ncbi Octenol as attractant to Nyssomyia neivai (Diptera:Psychodidae:Phlebotominae) in the field
    M C Pinto
    Laboratorio de Parasitologia, Departamento de Ciencias Biologicas, Faculdade de Ciencias Farmaceuticas, Universidade Estadual Julio de Mesquita Filho, 14801 902 Araraquara SP, Brazil
    J Med Entomol 48:39-44. 2011
    ..neivai than control and octenol at 0.5 mg/h with and without light. This is the first report that shows that octenol itself is attractive to N. neivai and associated with light traps significantly increases the catches...
  11. ncbi Neurobehavioral effects during experimental exposure to 1-octanol and isopropanol
    Christoph van Thriel
    Leibniz Research Centre for Working Environment and Human Factors Institut für Arbeitsphysiologie an der Universität Dortmund, Dortmund, Germany
    Scand J Work Environ Health 29:143-51. 2003
    ..The study examined acute neurobehavioral effects provoked by controlled exposure to 1-octanol and isopropanol among male volunteers...
  12. ncbi Toxic effect of aliphatic alcohols against susceptible and permethrin-resistant Pediculus humanus capitis (Anoplura: Pediculidae)
    G Mougabure Cueto
    Centro de Investigaciones de Plagas e Insecticidas CITEFA CONICET, Buenos Aires, Argentina
    J Med Entomol 39:457-60. 2002
    ..The pediculicidal effect of aliphatic alcohols demonstrated in this study and the lack of correlation with the permethrin resistance may prove to have a practical value for use in susceptible and permethrin-resistant head lice control...
  13. ncbi Evaluation of the enantiomers of 1-octen-3-ol and 1-octyn-3-ol as attractants for mosquitoes associated with a freshwater swamp in Florida, U.S.A
    D L Kline
    Center for Medical, Agricultural and Veterinary Entomology, United States, Department of Agriculture Agriculture Research Service, Gainesville, Florida, U S A
    Med Vet Entomol 21:323-31. 2007
    ....
  14. pmc Characterization of an enantioselective odorant receptor in the yellow fever mosquito Aedes aegypti
    Jonathan D Bohbot
    United States Department of Agriculture, Agricultural Research Service, Henry A Wallace Beltsville Agricultural Research Center, Plant Sciences Institute, Invasive Insect Biocontrol and Behavior Laboratory, Beltsville, Maryland, USA
    PLoS ONE 4:e7032. 2009
    ....
  15. ncbi Linoleic acid 10-hydroperoxide as an intermediate during formation of 1-octen-3-ol from linoleic acid in Lentinus decadetes
    Kenji Matsui
    Department of Biological Chemistry, Faculty of Agriculture, Yamaguchi University, Yamaguchi, Japan
    Biosci Biotechnol Biochem 67:2280-2. 2003
    ..At the same time, an accumulation of linoleic acid 10-hydroxide could be detected. The 10-hydroperoxide therefore seems to be an intermediate on the biosynthetic pathway...
  16. ncbi A GC-MS study of the volatile organic composition of straw and oyster mushrooms during maturity and its relation to antioxidant activity
    Zhuo Min Zhang
    School of Chemistry and Chemical Engineering, Sun Yat Sen University, Guangzhou 510275, P R China
    J Chromatogr Sci 46:690-6. 2008
    ....
  17. ncbi Quantitative structure-property relationship of aromatic sulfur-containing carboxylates
    Xin hui Liu
    State Key Laboratory of Environmental Simulation and Pollution Control, Institute of Environmental Sciences, Beijing Normal University, Beijing 100875, China
    J Environ Sci (China) 15:721-7. 2003
    ..For water solubility (log SW) and octanol/water partition coefficient (log KOW), the correction coefficients r2adj (adjusted for degrees of freedom) are 0.936 and 0.938, and the standard deviations are 0.364 and 0.223, respectively...
  18. ncbi Comparison of QSPR models of octanol/water partition coefficient for vitamins and non vitamins
    I Raska
    3rd Medical Department, 1st Faculty of Medicine, Charles University in Prague, U Nemocnice 1, 12808 Prague 2, Czech Republic
    Eur J Med Chem 41:1271-8. 2006
    ....
  19. ncbi A neural network based prediction of octanol-water partition coefficients using atomic5 fragmental descriptors
    Laszlo Molnar
    Department of Chemical Information Technology, Budapest University of Technology and Economics, Szent Gellért tér 4, H 1111 Budapest, Hungary
    Bioorg Med Chem Lett 14:851-3. 2004
    ..We used a pre-selected set of organic molecules from PHYSPROP database as training and test sets for a feedforward neural network. Results demonstrate the superiority of our non-linear model over the traditional linear method...
  20. ncbi Vapour pressures, aqueous solubilities, Henry's Law constants, and octanol/water partition coefficients of a series of mixed halogenated dimethyl bipyrroles
    Sheryl A Tittlemier
    Centre for Analytical and Environmental Chemistry, Carleton University, Ottawa, Ont, Canada K1S 5B6
    Chemosphere 57:1373-81. 2004
    ..Only slight differences in behaviour amongst HDBP congeners were predicted since substitution of a bromine for a chlorine (Cl/Br substitution) atom had less effect than H/Cl or H/Br substitution on P(o)(L,25), S(w,25), H25, and K(ow)...
  21. ncbi Thermodynamic study of sublimation, solubility, solvation, and distribution processes of atenolol and pindolol
    German L Perlovich
    Institute of Pharmacy, University of Tromsø, Breivika, N 9037 Tromsø, Norway
    Mol Pharm 4:929-35. 2007
    ..The impact of mutual dissolution of water and n-octanol molecules in the water/n-octanol system on distribution coefficients is discussed...
  22. ncbi Estimation of selected physicochemical properties for methylated naphthalene compounds
    Petros Dimitriou-Christidis
    Department of Civil Engineering, Texas A and M University, College Station, TX 77843 3136, USA
    Chemosphere 52:869-81. 2003
    ..Comparison of the estimated values with values predicted by EPIWIN indicated that EPIWIN is useful in giving order-of-magnitude prediction of physicochemical properties...
  23. pmc Partitioning of amino acid side chains into lipid bilayers: results from computer simulations and comparison to experiment
    Justin L MacCallum
    Department of Biological Sciences, University of Calgary, Calgary, Alberta, Canada
    J Gen Physiol 129:371-7. 2007
  24. pmc Membrane protein insertion: the biology-physics nexus
    Stephen H White
    Department of Physiology and Biophysics, University of California, Irvine, CA 92697, USA
    J Gen Physiol 129:363-9. 2007
  25. ncbi Theoretical property predictions
    David J Livingstone
    ChemQuest, Delamere House, 1 Royal Crescent, Sandown, Isle of Wight, PO36 8LZ, UK
    Curr Top Med Chem 3:1171-92. 2003
    ..Web references are given for both commercial and public domain software which is available for property prediction from chemical structure...
  26. ncbi Transtegumental diffusion of benzimidazole anthelmintics into Moniezia benedeni: correlation with their octanol-water partition coefficients
    M L Mottier
    Laboratorio de Farmacologia, Departamento de Fisiopatologia, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Pcia de Buenos Aires, Pje Arroyo Seco, Campus Universitario, Tandil 7000, Buenos Aries, Argentina
    Exp Parasitol 103:1-7. 2003
    ....
  27. ncbi The influence of drug partition coefficient on follicular penetration: in vitro human skin studies
    Yakov Frum
    Division of Pharmaceutical Sciences, University of Strathclyde, SIPBS, 27 Taylor Street, Glasgow G4 0NR, Scotland, UK
    Eur J Pharm Sci 30:280-7. 2007
    ..Identification of these other active properties would require performing this kind of a study on a much larger set of candidate drugs...
  28. ncbi SVM approach for predicting LogP
    Quan Liao
    Department of Computer Chemistry and Chemoinformatics, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China
    Mol Divers 10:301-9. 2006
    ..Based upon the comparison of several prediction logP models, i.e. Support Vector Machines (SVM), Partial Least Squares (PLS) and Multiple Linear Regression (MLR), the authors reported SVM model is the best one in this paper...
  29. ncbi A universal molecular descriptor system for prediction of logP, logS, logBB, and absorption
    Hongmao Sun
    Discovery Chemistry, Hoffmann La Roche Inc, 340 Kingsland Street, Nutley, New Jersey 07110, USA
    J Chem Inf Comput Sci 44:748-57. 2004
    ..The first three components of a five-component PLS-DA model were sufficient to clearly separate the 169 drug molecules, collected by Abraham, into three classes, according to their percentage human intestinal absorption...
  30. ncbi Effect of buoyancy on appearance and characteristics of surface tension repeated auto-oscillations
    N M Kovalchuk
    Institute of Biocolloid Chemistry, 03142 Kiev, Ukraine
    J Phys Chem B 109:15037-47. 2005
    ..The buoyancy force affects also the dependence of the oscillation characteristics on the system dimensions. The results of the simulations are compared with the available experimental data...
  31. ncbi Limitation of Potts and Guy's model and a predictive algorithm for skin permeability including the effects of hydrogen-bond on diffusivity
    X C Fu
    Department of Pharmacy, Zhejiang University City College, Hangzhou, PR China
    Pharmazie 59:282-5. 2004
    ..The calculated log P values from the latter model are in good accordance with respective experimental ones for the data set...
  32. ncbi Partitioning of polychlorinated biphenyls in octanol/water, triolein/water, and membrane/water systems
    Thomas W Jabusch
    Division of Environmental Health Sciences, School of Public Health, University of Minnesota, Mayo Mail Code 807, Minneapolis, MN 55455, USA
    Chemosphere 60:1270-8. 2005
    ..But the observed differences between Kow and Kmw also indicate that using Kow to predict accumulation of POPs, particularly highly hydrophobic ones, in the polar lipids of organisms will underestimate their concentrations at equilibrium...
  33. ncbi Synthesis and transdermal penetration of NSAID glycoside esters
    Henk Swart
    School of Pharmacy, North West University, Potchefstroom 2520, South Africa
    Int J Pharm 301:71-9. 2005
    ..Experimental transdermal flux data showed that the parent NSAIDs penetrated human skin to a much higher extent than the glycosides...
  34. ncbi Octanol/water partition coefficients of chloronaphthalenes
    T Puzyn
    Department of Environmental Chemistry and Ecotoxicology, Faculty of Chemistry, University of Gdansk, Gdansk, Poland
    J Environ Sci Health A Tox Hazard Subst Environ Eng 40:1651-63. 2005
    ..4191). Minimal values of log Kow of chloronaphthalenes ranged between 3.57 and 3.90 for 1-chloronaphthalene, whereas maximal values ranged between 6.36 and 7.19 for octachloronaphthalene...
  35. ncbi Solid phase dosing and sampling technique to determine partition coefficients of hydrophobic chemicals in complex matrixes
    Thomas L Ter Laak
    Institute for Risk Assessment Sciences IRAS, Utrecht University, Yalelaan 2, P O Box 80176, 3508 TD Utrecht, The Netherlands
    Environ Sci Technol 39:3736-42. 2005
    ..05 log units). Therefore, this method might be applied to determine sorption coefficients of numerous, even more hydrophobic compounds, to humic acids as well as other dissolved hydrophobic matrixes...
  36. ncbi Critical body residues linked to octanol-water partitioning, organism composition, and LC50 QSARs: meta-analysis and model
    A Jan Hendriks
    Department of Environmental Science, Institute for Wetland and Water Research, Faculty of Science, Radboud University Nijmegen, PO Box 9010, NL 6500 GL, Nijmegen, The Netherlands
    Environ Sci Technol 39:3226-36. 2005
    ..Moreover, the concept is applied to species (e.g., plants, lean animals) and substances (e.g., specific modes of action) that were scarcely studied quantitatively so far...
  37. ncbi Occurrence of pharmaceutical products in a municipal effluent and toxicity to rainbow trout (Oncorhynchus mykiss) hepatocytes
    F Gagne
    St Lawrence Centre, Environment Canada, 105 McGill St, Montreal, QC, Canada H2Y 2E7
    Ecotoxicol Environ Saf 64:329-36. 2006
    ..These products have the potential to produce a toxic response in aquatic organisms and the above biomarkers were shown to respond readily to PPCPs in aquatic organisms...
  38. ncbi An approach to determining applicability domains for QSAR group contribution models: an analysis of SRC KOWWIN
    Nina Nikolova-Jeliazkova
    Institute of Parallel Processing, Bulgarian Academy of Sciences, Sofia, Bulgaria
    Altern Lab Anim 33:461-70. 2005
    ....
  39. ncbi Recent methodologies for the estimation of n-octanol/water partition coefficients and their use in the prediction of membrane transport properties of drugs
    Gilles Klopman
    Department of Chemistry, Case Western Reserve University, 10900 Euclid Ave, Cleveland, Ohio 44106, USA
    Mini Rev Med Chem 5:127-33. 2005
    ..Recent uses of these partition coefficient algorithms in the development of membrane transport models are also discussed...
  40. ncbi Effect of dl-homocysteic acid on W/O microemulsions of potassium naphthenate/1-octanol-n-heptane
    Xu Zhang
    The State Key Laboratory of Rare Earth Materials Chemistry and Applications, Department of Chemical Biology, College of Chemistry, Peking University, Beijing 100871, China
    J Colloid Interface Sci 283:231-7. 2005
    ..3) The microstructure of the solubilized water remains unchanged, except that the polarity of the interface is affected. (4) The transition point is reduced to lower water content. A possible mechanism is proposed...
  41. ncbi Determination of solute lipophilicity by reversed-phase high-performance liquid chromatography (RP-HPLC)
    Xiangli Liu
    Department of Molecular Analytical Chemistry, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan
    J Med Invest 52:293-4. 2005
    ..The chromatographic results show that, under the conditions of study, the lipophilicity index log kw was highly correlated with the experimental log Poct...
  42. ncbi Characterization of soluble microbial products (SMP) derived from glucose and phenol in dual substrate activated sludge bioreactors
    Benjamin S Magbanua
    Department of Civil Engineering, Mississippi State University, Mississippi State, MS 39762, USA
    Biotechnol Bioeng 93:862-70. 2006
    ..However, glucose-derived SMP were generally more toxic than glucose itself (a non-toxic substrate), and the toxicity increased linearly with the concentration of SMP...
  43. ncbi Quantitative structure-activity relationship modeling of acute toxicity of quaternary alkylammonium sulfobetaines to Daphnia magna
    Joanna Davies
    University of Wales Swansea, Singleton Park, Swansea SA2 8PP, United Kingdom
    Environ Toxicol Chem 23:2111-5. 2004
    ..The established QSAR equation for such zwitterionic compounds is consistent with the standard equation that normally defines the polar narcosis mode of toxic action...
  44. ncbi Relationships between LC retention, octanol-water partition coefficient, and fungistatic properties of 2-(2,4-dihydroxyphenyl)benzothiazoles
    Joanna Matysiak
    University of Agriculture, Department of Chemistry, Akademicka 15, 20 950 Lublin, Poland
    J AOAC Int 87:579-86. 2004
    ..Finally, the lipophilicity parameters were compared with the fungistatic properties of compounds expressed by log MIC (minimum inhibitory concentration) values to find quantitative structure activity relationship equations...
  45. ncbi Application of high-performance liquid chromatography based measurements of lipophilicity to model biological distribution
    Klara Valko
    Computational, Analytical and Structural Sciences, GlaxoSmithKline, Gunnels Wood Road Stevenage, Herts SG1 2NY, UK
    J Chromatogr A 1037:299-310. 2004
    ....
  46. ncbi log P estimation of 1,2-dithiole-3-thiones and 1,2-dithiole-3-ones: a comparison of experimental and calculative approaches
    Sylvain Gargadennec
    Laboratoire de Chimie Analytique, UPRES EA 2231, Faculte des Sciences Pharmaceutiques et Biologiques, Universite de Rennes 1, Rennes Cedex, France
    Pharm Res 22:875-82. 2005
    ....
  47. ncbi A linear free energy relationship treatment of the affinity between carboxymethylcellulose and basic drugs
    María V Ramírez Rigo
    Departamento de Farmacia, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    Mol Pharm 1:383-6. 2004
    ..In addition, water uptake and drug delivery were assayed with the product of neutralization of HCMC with atenolol, which was easily wetted, and the drug-HCMC interaction was found essentially reversible...
  48. ncbi Physico-chemical profiling of antidepressive sertraline: solubility, ionisation, lipophilicity
    Katalin Deák
    Semmelweis University, Department of Pharmaceutical Chemistry, H 1092 Hogyes Endre street 9 Budapest, Hungary
    Med Chem 2:385-9. 2006
    ..However, the good brain penetration can better be explained with the lack of polar interactions evidenced here by the zero DeltalogP (logPoct-logPch) value of sertraline...
  49. ncbi Modeling the octanol-water partition coefficients by an optimized molecular connectivity index
    Milan Soskić
    Department of Chemistry, Faculty of Agronomy, University of Zagreb, HR 10000 Zagreb, The Republic of Croatia
    J Chem Inf Model 45:930-8. 2005
    ..Intramolecular interactions, which are operative in more complex compounds, are treated in a similar fashion to that in the Hansch-Leo or Rekker methods, by inclusion of empirical correction factors...
  50. ncbi Slow-stirring method for determining the n-octanol/water partition coefficient (Pow) for highly hydrophobic chemicals: performance evaluation in a ring test
    Johannes Tolls
    Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Toxicol Chem 22:1051-7. 2003
    ..24 +/- 0.05 (mean +/- standard deviation). In combination, these results indicate that the slow-stirring method is precise and accurate and, thus, allows for reliable determination of log Pow of highly hydrophobic chemicals...
  51. ncbi The preparation and evaluation of sustained release suppositories containing ketoprofen and Eudragit RL 100 by using factorial design
    I Ozguney
    Department of Pharmaceutical Technology, Faculty of Pharmacy, Ege University, Bornova, Izmir, Turkey
    Pharm Dev Technol 12:97-107. 2007
    ..In addition to these studies, antiinflammatory activity of SR suppositories also determined that it was significantly extended according to the conventional suppositories...
  52. ncbi Use of the ciliated protozoan Tetrahymena pyriformis for the assessment of toxicity and quantitative structure--activity relationships of xenobiotics: comparison with the Microtox test
    P Bogaerts
    , UPRESA 6023, , , France
    Ecotoxicol Environ Saf 49:293-301. 2001
    ..No correlation was found with the Microtox test. For organic compounds, a significant correlation was observed between the hydrophobicity coefficient and the toxicity data. This correlation is closer with the two tests using Tetrahymena...
  53. ncbi Prediction of the aqueous solubility: comparison of the general solubility equation and the method using an amended solvation energy relationship
    Gang Yang
    Department of Pharmaceutical Sciences, College of Pharmacy, The University of Arizona, 1703 E Mabel Street, Tucson, Arizona 85721, USA
    J Pharm Sci 91:517-33. 2002
    ..These results are similar to those of the ASER method. The advantages and disadvantages of each method are discussed. It is shown that when the two methods agree with each other, they also agree with the experimentally determined values...
  54. ncbi The effect of ion pairing on the skin permeation of amlodipine
    Yuxuan Jiang
    Department of Pharmaceutics, Shenyang Pharmaceutical University, People s Republic of China
    Pharmazie 63:356-60. 2008
    ....
  55. ncbi Quantitative structure-permeability relationships (QSPRs) for percutaneous absorption
    G P Moss
    School of Pharmacy and Chemistry, Liverpool John Moores University, Byrom Street, Liverpool L3 3AF, UK
    Toxicol In Vitro 16:299-317. 2002
    ..In addition, the endpoint of models may be inappropriate for specific applications other than the systemic delivery of topically applied chemicals...
  56. ncbi Rapid method for the estimation of octanol/water partition coefficient (log P(oct)) from gradient RP-HPLC retention and a hydrogen bond acidity term (zetaalpha(2)(H))
    K Valko
    Hit Generation Sciences and Analytical Technologies, GlaxoWellcome Medicines Research Centre, Stevenage, Herts, SG1 2NY, United Kingdom
    Curr Med Chem 8:1137-46. 2001
    ..The cycle time of the generic gradient HPLC method is 5 minutes. The general solvation equation obtained for the log Poct values and the fast gradient Chromatographic Hydrophobicity Indices with acetonitrile (CHI(ACN)) and methanol..
  57. ncbi Novel atomic-level-based AI topological descriptors: application to QSPR/QSAR modeling
    Biye Ren
    Research Institute of Materials Science, South China University of Technology, Guangzhou 510640, P R China
    J Chem Inf Comput Sci 42:858-68. 2002
    ..These results indicate that both Xu and AI indices are useful model parameters for QSPR/QSAR analysis of complex compounds...
  58. ncbi Stability scale and atomic solvation parameters extracted from 1023 mutation experiments
    Hongyi Zhou
    Howard Hughes Medical Institute Center for Single Molecule Biophysics, Department of Physiology and Biophysics, State University of New York at Buffalo, Buffalo, New York 14214, USA
    Proteins 49:483-92. 2002
    ..80 and slope = 1.06, and r = 0.83 and slope = 0.93, respectively)...
  59. ncbi Direct measurement of octanol-water partition coefficients of some environmentally relevant brominated diphenyl ether congeners
    Eric Braekevelt
    Department of Fisheries and Oceans, Freshwater Institute, 501 University Cresent, Winnipeg, Manitoba, Canada R3T 2N6
    Chemosphere 51:563-7. 2003
    ..The tri- and tetrabrominated congeners are in the range of optimum bioaccumulation potential...
  60. ncbi Determination of lipophilicity and pKa measurement of some 4-imino-1,4-dihydrocinnoline-3-carboxylic acid and 4-oxo-1,4-dihydrocinnoline-3-carboxylic acid derivatives--isosteric analogues of quinolones
    Wiesława Lewgowd
    Department of Hospital Pharmacy, Medical University of Lodz, Muszynskiego 1, 90 151 Lodz, Poland
    Acta Pol Pharm 64:195-200. 2007
    ..Partition coefficient (log P), and dissociation constant (pKa) were experimentally determined and also calculated by the use of ACDLabs system software. The obtained values were correlated with experimental data...
  61. ncbi Molecular hologram derived quantitative structure-property relationships to predict physico-chemical properties of polychlorinated biphenyls
    Xiaodong Wang
    State Key Laboratory of Pollution Control and Resources Reuse, The School of Environment, Nanjing University, Nanjing 210093, PR China
    Chemosphere 51:617-32. 2003
    ..The results show that this new quantitative structure-activity relationship approach presents highly predictive models for important physico-chemical properties of PCBs...
  62. ncbi Prediction of aqueous solubility and partition coefficient optimized by a genetic algorithm based descriptor selection method
    Jörg K Wegner
    Zentrum für Bioinformatik Tübingen, Universitat Tubingen, Sand 1, D 72076 Tubingen, Germany
    J Chem Inf Comput Sci 43:1077-84. 2003
    ..54 were achieved. The logP data set was divided into a training set of 1853 compounds and a test set of 138 compounds. A correlation coefficient of 0.92 and an empirical standard deviation of 0.44 were achieved...
  63. ncbi The prediction of environmental fate for trifluoromethyl sulfur pentafluoride (SF5CF3),a potent greenhouse gas
    Wen Tien Tsai
    Graduate Institute of Bioresources, National Pingtung University of Science and Technology, Pingtung 912, Taiwan
    J Hazard Mater 149:747-51. 2007
    ..These predicted distribution properties have led to the suggestion that it will sink into the atmosphere if it is released into the environment...
  64. ncbi Prediction of Setschenow constants
    Nina Ni
    College of Pharmacy, The University of Arizona, Tucson, AZ 85721, USA
    Int J Pharm 254:167-72. 2003
    ..It also shows that the partition coefficient is a better descriptor of salting out than either molar volume or solubility...
  65. ncbi Sulfonic acid resin-catalyzed addition of phenols, carboxylic acids, and water to olefins: Model reactions for catalytic upgrading of bio-oil
    Zhi Jun Zhang
    Key Laboratory of Bio based Material Science and Technology Northeast Forestry University, Ministry of Education, Harbin 150040, PR China
    Bioresour Technol 101:3685-95. 2010
    ..b>Octanols and dioctyl ethers were formed from water and octyl acetates and phenol acetates from acetic acid...
  66. ncbi Comparative study on the in vitro human skin permeation of monoterpenes and phenylpropanoids applied in rose oil and in form of neat single compounds
    S Schmitt
    Institute of Pharmacy and Molecular Biotechnology, University of Heidelberg, Germany
    Pharmazie 65:102-5. 2010
    ..This suggests that co-operative interactions between essential oil components may promote skin permeation behaviour of essential oil and its components...
  67. ncbi Dispersed three-pulse infrared photon echoes of nitrous oxide in water and octanol
    J T Shattuck
    Department of Chemistry and The Photonics Center, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215, United States
    J Phys Chem B 117:15774-85. 2013
    ..These results demonstrate the value of the N2O molecule to act as a reporter of equilibrium fluctuations in such complex systems particularly due to its solubility characteristics and long vibrational lifetime. ..
  68. ncbi Solvent constraints on the property space of acetylcholine. 2. Ordered media
    Giulio Vistoli
    Istituto di Chimica Farmaceutica, Facolta di Farmacia, Universita di Milano, Viale Abruzzi 42, I 20131 Milan, Italy
    J Med Chem 48:6926-35. 2005
    ....
  69. ncbi Validated models for predicting skin penetration from different vehicles
    Taravat Ghafourian
    Medway School of Pharmacy, Universities of Kent and Greenwich, Central Avenue, Chatham Maritime, Kent ME4 4TB, UK
    Eur J Pharm Sci 41:612-6. 2010
    ..The QSAR was validated internally, using a leave-many-out procedure, giving a mean absolute error of 0.454 for the logkp value of the test set...
  70. ncbi Modelling bioaccumulation of semi-volatile organic compounds (SOCs) from air in plants based on allometric principles
    Nils L L Steyaert
    Department of Environmental Science, Institute for Wetland and Water Research, Radboud University Nijmegen, P O Box 9010, 6500 GL Nijmegen, The Netherlands
    Chemosphere 77:727-32. 2009
    ..Validation on independent data showed that bio-concentration factors of PCBs, chlorobenzenes and other chemicals were predicted well by the model. For pesticides, polycyclic aromatic hydrocarbons and dioxins deviations occurred...
  71. ncbi Predictive performance of the human Cell Line Activation Test (h-CLAT) for lipophilic chemicals with high octanol-water partition coefficients
    Osamu Takenouchi
    Safety Science Research Laboratories, Kao Corporation, Japan
    J Toxicol Sci 38:599-609. 2013
    ..Our results demonstrated that the h-CLAT could predict sensitizing potential of various chemicals, which contain lipophilic chemicals using a large-scale chemical dataset. ..
  72. ncbi Identification of a novel peptide that interferes with the chemical regulation of connexin43
    Junko Shibayama
    Department of Pharmacology, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA
    Circ Res 98:1365-72. 2006
    ..These data suggest that RXP-based peptides could serve as tools to help determine the role of Cx43 as a regulator of function in conditions such as ischemia-induced arrhythmias...
  73. ncbi [Study on the chemical constituents of the volatile oil from aerial parts of Isodon eriocalyx var. laxiflora]
    Zhi Na
    Xishuangbanna Tropical Botanical Garden, The Chinese Academy of Sciences, Mengla 666303, China
    Zhongguo Zhong Yao Za Zhi 30:1268-70. 2005
    ..To study the chemical constituents of the volatile oil from the aerial parts of Isodon eriocalyx var. laxiflora...
  74. ncbi Evaluation of octenol and Lurex as baits in Mosquito Magnet Pro traps to collect vector mosquitoes in China
    Chun Xiao Li
    Department of Vector Biology and Control, Institute of Microbiology and Epidemiology, State Key Laboratory of Pathogen and Biosecurity, 20 Dongdajie, Fengtai District, Beijing 100071, China
    J Am Mosq Control Assoc 26:449-51. 2010
    ..albopictus than the number collected by the traps alone at 2 areas in Beijing...
  75. ncbi The hepatoprotective effects of dihydromyrcenol and geranyl formate in an experimental model of acute hepatic injury induced by the use of carbon tetrachloride
    Irfan Bayram
    Yuzuncu Yil University, Faculty of Medicine Department of Pathology, Van, Turkey
    Turk J Gastroenterol 22:594-601. 2011
    ..We aimed to investigate the hepatoprotective effects of dihydromyrcenol and geranyl formate extracted from the Vitis vinifera L. plant in a rat model of acute hepatic injury induced by carbon tetrachloride...
  76. ncbi Leaded-gasoline additives still contaminate groundwater
    Ronald W Falta
    Clemson University, USA
    Environ Sci Technol 39:379A-384A. 2005
  77. ncbi Formation and conformation of baicalin-berberine and wogonoside-berberine complexes
    Jing Rong Wang
    State Key Laboratory of Quality Research in Chinese Medicine, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, China
    Chem Pharm Bull (Tokyo) 60:706-11. 2012
    ....
  78. ncbi Zwitterions can be predominant in membrane penetration of drugs: experimental proof
    Károly Mazák
    Research Group of Drugs of Abuse and Doping Agents, Department of Pharmaceutical Chemistry, Semmelweis University, Hungarian Academy of Sciences, Hogyes E u 9, H 1092 Budapest, Hungary
    J Med Chem 55:6942-7. 2012
    ..The lipophilicity profile of these zwitterionic compounds is expressed, calculated, and depicted in terms of species-specific lipophilicities over the entire pH range...
  79. ncbi A K(ow)-based QSAR model for predicting toxicity of halogenated benzenes to all algae regardless of species
    Ming Zeng
    State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, 200092 Shanghai, China
    Bull Environ Contam Toxicol 86:565-70. 2011
    ..001. This model provides evidence that the toxicity of halogenated benzenes to these five algae tested is related to the slower transference into lipid. This model can potentially be generalized to other algal species and toxicants...
  80. ncbi Mechanical-stimulation-evoked calcium waves in proliferating and differentiated human keratinocytes
    Moe Tsutsumi
    Shiseido Research Center, 2 12 1, Fukuura, Kanazawa Ku, Yokohama, 236 8643, Japan
    Cell Tissue Res 338:99-106. 2009
    ..Thus, signaling via gap junctions might be involved in the induction of calcium waves in response to mechanical stress at the upper layer of the epidermis...
  81. pmc Odor coding in the maxillary palp of the malaria vector mosquito Anopheles gambiae
    Tan Lu
    Department of Biological Sciences, Center for Molecular Neuroscience, Institute of Chemical Biology and Global Health and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee 37235, USA
    Curr Biol 17:1533-44. 2007
    ..However, the molecular and cellular basis of such olfactory responses remains largely unknown...
  82. ncbi A system for LogD screening of 96-well plates using a water-plug aspiration/injection method combined with high-performance liquid chromatography-mass spectrometry
    Yukifumi Dohta
    Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, 3 Okubo, Tsukuba, Ibaraki 300 2611, Japan
    Anal Chem 79:8312-5. 2007
    ..LogD values of some common drugs measured using the HSLogD agreed with reported LogD values (0 < LogD < 5)...
  83. ncbi Comparison of hydrogen bonding in 1-octanol and 2-octanol as probed by spectroscopic techniques
    Francesca Palombo
    Dipartimento di Chimica, Universita di Perugia, Via Elce di Sotto, 8, I 06100 Perugia, Italy
    J Phys Chem B 110:18017-25. 2006
    ..The different degree of self-association for the two octanols is attributed to entropic factors...
  84. ncbi Simplified pesticide multiresidue analysis of soybean oil by low-temperature cleanup and dispersive solid-phase extraction coupled with gas chromatography/mass spectrometry
    Li Li
    China Agricultural University, College of Science, Beijing, 100094, People s Republic of China
    J AOAC Int 90:1387-94. 2007
    ..02, 0.05, 0.2, and 1 mg/kg. The relative standard deviation was <20% even for determinations without internal standards. Limits of quantitation ranged from 20 to 250 microg/kg...
  85. ncbi Preclinical characterization of anticancer gallium(III) complexes: solubility, stability, lipophilicity and binding to serum proteins
    Alexander V Rudnev
    Vernadsky Institute of Geochemistry and Analytical Chemistry, Russian Academy of Sciences, Kosygin St 19, 119991 Moscow, Russia
    J Inorg Biochem 100:1819-26. 2006
    ..A tendency of being faster converted into the protein-bound form found for KP1089 (due possibly to non-covalent binding) seems complementary to its greater in vitro antiproliferative activity...
  86. ncbi Development and evaluation of an artificial membrane for determination of drug availability
    Thorsteinn Loftsson
    Faculty of Pharmacy, University of Iceland, Hofsvallagata 53, IS 107 Reykjavik, Iceland
    Int J Pharm 326:60-8. 2006
    ..Drug permeation patterns from cyclodextrin containing formulations through the membrane were similar to those previously observed for biological membranes such as hairless mouse skin and the eye cornea...
  87. ncbi Improvement of microemulsion electrokinetic chromatography for measuring octanol-water partition coefficients
    Zhining Xia
    Department of Pharmaceutics, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing, P R China
    Electrophoresis 29:835-42. 2008
    ..The log P(ow) of all analytes obtained by I-MEEKC agreed with those obtained by classical shake flask or literature values, the errors between them were within 0.1 logarithm units, better than the ones by conventional MEEKC...
  88. ncbi Effect of lipase immobilization on resolution of (R, S)-2-octanol in nonaqueous media using modified ultrastable-Y molecular sieve as support
    Dazhang Dai
    Department of Chemical Engineering and Bioengineering, Zhejiang University, Hangzhou 310027, The People s Republic of China
    Appl Biochem Biotechnol 134:39-50. 2006
    ..5, 50 degrees C for 24 h, demonstrating a good application potential in the production of optically pure (R, S)-2-octanol...
  89. pmc A revised role for P-glycoprotein in the brain distribution of dexamethasone, cortisol, and corticosterone in wild-type and ABCB1A/B-deficient mice
    Brittany L Mason
    Pharmaceutical Science Research Division, King s College London, London, UK
    Endocrinology 149:5244-53. 2008
    ..Therefore, our current understanding of the role of P-gp in hypothalamic-pituitary-adrenal regulation in mice requires revision...
  90. ncbi Fragrance material review on tetrahydromuguol
    A Lapczynski
    Research Institute for Fragrance Materials Inc, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 46:S289-91. 2008
    ..A toxicologic and dermatologic review of tetrahydromuguol when used as a fragrance ingredient is presented...
  91. ncbi Fragrance material review on tetrahydrolinalool
    A Lapczynski
    Research Institute for Fragrance Materials Inc, Woodcliff Lake, NJ 07677, USA
    Food Chem Toxicol 46:S286-8. 2008
    ..A toxicologic and dermatologic review of tetrahydrolinalool when used as a fragrance ingredient is presented...
  92. ncbi Parameterization of an empirical model for the prediction of n-octanol, alkane and cyclohexane/water as well as brain/blood partition coefficients
    Mohamed Zerara
    Department of Chemistry, Darmstadt University of Technology, Petersenstr 20, 64287 Darmstadt, Germany
    J Comput Aided Mol Des 23:105-11. 2009
    ..Comparison of both logP(alk) and logP(cyc) with the logarithms of brain/blood ratios (logBB) for a set of structurally diverse compounds revealed a high correlation showing their superiority over the logP(oct) measure in this context...
  93. ncbi Water immiscible ionic liquids as solvents for whole cell biocatalysis
    Holger Pfruender
    Institute of Biochemical Engineering, Munich University of Technology, Garching, Germany
    J Biotechnol 124:182-90. 2006
    ..This result demonstrates that good mass transfer rates can be obtained despite the relatively high viscosity of ionic liquids...
  94. ncbi Virtual quantification of metabolites by capillary electrophoresis-electrospray ionization-mass spectrometry: predicting ionization efficiency without chemical standards
    Kenneth R Chalcraft
    Department of Chemistry, McMaster University, Hamilton, Ontario, L8S 4M1, Canada
    Anal Chem 81:2506-15. 2009
    ..New strategies for predicting ionization efficiency in silico allow for rapid and semiquantitative analysis of newly discovered biomarkers and/or drug metabolites in metabolomics research when chemical standards do not exist...
  95. ncbi Quantification of gap junctional intercellular communication based on digital image analysis
    Johannes P Hofgaard
    Danish National Research Foundation Centre for Cardiac Arrhythmia and Department of Biomedical Sciences, Faculty of Health Sciences, University of Copenhagen, Copenhagen N, Denmark
    Am J Physiol Regul Integr Comp Physiol 297:R243-7. 2009
    ..This new method of analysis yields a rapid and objective quantification process with a high degree of reproducibility...
  96. ncbi Physicochemical substance properties as indicators for unreliable exposure in microplate-based bioassays
    Janet Riedl
    UFZ Helmholtz Centre for Environmental Research, Department Bioanalytical Ecotoxicology, Permoserstrasse 15, 04318 Leipzig, Germany
    Chemosphere 67:2210-20. 2007
    ....
  97. ncbi Henry's law constant, octanol-air partition coefficient and supercooled liquid vapor pressure of carbazole as a function of temperature: application to gas/particle partitioning in the atmosphere
    Mustafa Odabasi
    Faculty of Engineering, Department of Environmental Engineering, Dokuz Eylul University, Kaynaklar Campus, 35160 Buca, Izmir, Turkey
    Chemosphere 62:1087-96. 2006
    ..However, overall there was a good agreement between the measured Kp and soot-based model predictions...
  98. ncbi Octanol modulation of neuronal nicotinic acetylcholine receptor single channels
    Yi Zuo
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Medical School, 303 E Chicago Ave, Chicago, IL 60611, USA
    Alcohol Clin Exp Res 28:1648-56. 2004
    ..In this study, we examined the detailed mechanism of the inhibitory action of the long-chain alcohol n-octanol on the neuronal nicotinic AChR...
  99. ncbi Method for measuring the logarithm of the octanol-water partition coefficient by using short octadecyl-poly(vinyl alcohol) high-performance liquid chromatography columns
    Stephen F Donovan
    BASF, Princeton, NJ 08543 0400, USA
    J Chromatogr A 952:47-61. 2002
    ....
  100. ncbi Increased dilator response to heptanol and octanol in aorta from DOCA-salt-hypertensive rats
    R Leite
    Department of Pharmacology, Federal University of Minas Gerais, Belo Horizonte MG, Brazil
    Pharmacology 62:29-35. 2001
    ....
  101. ncbi Enriched odor exposure increases the number of newborn neurons in the adult olfactory bulb and improves odor memory
    Christelle Rochefort
    Perception and Memory Laboratory, Centre National de la Recherche Scientifique Unité de Recherche Associée 2182, Institut Pasteur, 75 724 Paris Cedex 15, France
    J Neurosci 22:2679-89. 2002
    ..By maintaining a constitutive turnover of granule cells subjected to modulation by environmental cues, ongoing bulbar neurogenesis could be associated with improved olfactory memory...

Research Grants23

  1. FLUID BILAYER INTERACTIONS WITH PEPTIDES
    Stephen White; Fiscal Year: 2004
    ..5) Expand and improve physicochemical rules for predicting the binding and folding of peptides at membrane interfaces, and establish a structural context for them. ..
  2. HSV-2 and Down-Regulations of Gap Junctions
    RICHARD WOODRUFF; Fiscal Year: 2003
    ..Furthermore, we will take advantage of these techniques to investigate specifically how the virus effects gap junctions, and how important to infectivity is closure of these channels of intercellular communication. ..
  3. Neuromuscular synaptogenesis in zebrafish
    Rita Balice Gordon; Fiscal Year: 2004
    ....
  4. Genetic approaches to neurotrophin signaling
    Rita Balice Gordon; Fiscal Year: 2006
    ....
  5. Integrated Protein Surface Annotation Suite
    Maxim Totrov; Fiscal Year: 2006
    ..The surface annotation suite will be marketed as a separate module for the ICM molecular modelling package and oriented towards use by biologists and biochemists. [unreadable] [unreadable] [unreadable]..
  6. Genetics of neuromuscular synaptogenesis in zebrafish
    Rita Balice Gordon; Fiscal Year: 2008
    ..Identification of the underlying genetic defects in these mutants will expand our understanding of the molecular mechanisms that mediate the formation and function of neuromuscular and other synapses. ..
  7. Identification of Alcohol Binding Site(s) in Protein Kinase C Epsilon
    Joydip Das; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  8. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  9. Volatile Anesthesia and the GABAA Receptor Gamma Subunit
    Stuart Forman; Fiscal Year: 2009
    ..abstract_text> ..
  10. Cold Neutrons For Biology And Technology
    Stephen White; Fiscal Year: 2005
    ..We foresee a future when computer simulations will allow three-dimensional detail to be inferred routinely from 1- and 2-dimensional neutron and X-ray data. ..
  11. Trk-mediated signaling at neuromuscular synapses
    Rita Balice Gordon; Fiscal Year: 2005
    ....
  12. Vesicle recycling at developing NMJs
    Rita J Balice Gordon; Fiscal Year: 2010
    ....
  13. Rational Design of Inhibitors of Yersinia pestis EF-Tu
    Maxim Totrov; Fiscal Year: 2004
    ..abstract_text> ..
  14. RATIONAL DEVELOPMENT OF THYROID RECEPTOR ANTAGONISTS
    Maxim Totrov; Fiscal Year: 2004
    ..abstract_text> ..
  15. Structure of the Glycine Receptor's Alcohol Binding Site
    INGRID LOBO; Fiscal Year: 2003
    ..abstract_text> ..
  16. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  17. Rational Development of TCF/Beta-Catenin Antagonists
    Maxim Totrov; Fiscal Year: 2004
    ....
  18. Concerted membrane diffraction and simulation studies
    Stephen White; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  19. General Anesthetics and nAcCHOR Agonist Affinity
    Douglas Raines; Fiscal Year: 2004
    ....
  20. 2007 Microfluidics, Physics & Chemistry of Gordon Research Conference
    SABETH VERPOORTE; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  21. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....
  22. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....