eicosanoic acids

Summary

Summary: 20-carbon saturated monocarboxylic acids.

Top Publications

  1. ncbi Dietary supplementation with (n-3) polyunsaturated fatty acids does not affect insulin sensitivity in healthy Labrador retriever dogs
    Andrew J Irvine
    Centre for Nutrition and Food Science, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
    J Nutr 132:1709S-10S. 2002
  2. ncbi Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults
    F Thies
    Department of Biochemistry, University of Oxford, United Kingdom
    Lipids 36:1183-93. 2001
  3. ncbi Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro
    Ann Sofi Johansson
    Department of Public Health and Caring Sciences, Uppsala University, Rudbeck Laboratory, Sweden
    FEBS J 274:990-1000. 2007
  4. pmc Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study)
    M P Bonham
    Northern Ireland Centre for Food and Health NICHE, Department of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Prostaglandins Leukot Essent Fatty Acids 78:343-50. 2008
  5. ncbi The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype
    Eliz Anil
    Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, PO Box 226, University of Reading, Whiteknights, Reading RG6 6AP, UK
    Proc Nutr Soc 66:60-8. 2007
  6. pmc Phospholipase A2 activity triggers the wound-activated chemical defense in the diatom Thalassiosira rotula
    Georg Pohnert
    Max Planck Institut für Chemische Okologie, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Plant Physiol 129:103-11. 2002
  7. ncbi A systematic method for the sensitive and specific determination of hair lipids in combination with chromatography
    Yoshinori Masukawa
    Tochigi Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga, Tochigi 321 3497, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 823:131-42. 2005
  8. ncbi Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds
    Valle Fernández-Moya
    Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Av Padre Garcia Tejero 4, 41012 Sevilla, Spain
    Planta 216:834-40. 2003
  9. ncbi Identification and functional characterization of the moss Physcomitrella patens delta5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis
    Songsri Kaewsuwan
    Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, 447 Sri Ayudhya Road, Ratchathewi, Bangkok 10400, Thailand
    J Biol Chem 281:21988-97. 2006
  10. ncbi Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 50:601-8. 2007

Research Grants

  1. EICOSANOIC ACIDS IN TRYPANOSOMA BRUCEI
    LAWRENCE RUBEN; Fiscal Year: 2002
  2. Mechanisms of resistance artery contraction
    JOSEPH ELLIOTT BRAYDEN; Fiscal Year: 2010
  3. Conference on Oxidative Mechanisms in Neurodegeneration
    Grace Sun; Fiscal Year: 2004
  4. Function and regulation of cardiac Na transporters
    Donald Hilgemann; Fiscal Year: 2008

Scientific Experts

Detail Information

Publications130 found, 100 shown here

  1. ncbi Dietary supplementation with (n-3) polyunsaturated fatty acids does not affect insulin sensitivity in healthy Labrador retriever dogs
    Andrew J Irvine
    Centre for Nutrition and Food Science, School of Biomedical and Life Sciences, University of Surrey, Guildford, UK
    J Nutr 132:1709S-10S. 2002
  2. ncbi Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults
    F Thies
    Department of Biochemistry, University of Oxford, United Kingdom
    Lipids 36:1183-93. 2001
    ....
  3. ncbi Docosahexaenoic acid stabilizes soluble amyloid-beta protofibrils and sustains amyloid-beta-induced neurotoxicity in vitro
    Ann Sofi Johansson
    Department of Public Health and Caring Sciences, Uppsala University, Rudbeck Laboratory, Sweden
    FEBS J 274:990-1000. 2007
    ..Consequently, AbetaArctic-induced toxicity could not be sustained using docosahexaenoic acid. These results provide new insights into the toxicity of different Abeta aggregates and how endogenous lipids can affect Abeta aggregation...
  4. pmc Habitual fish consumption does not prevent a decrease in LCPUFA status in pregnant women (the Seychelles Child Development Nutrition Study)
    M P Bonham
    Northern Ireland Centre for Food and Health NICHE, Department of Biomedical Sciences, University of Ulster, Cromore Road, Coleraine BT52 1SA, Northern Ireland, UK
    Prostaglandins Leukot Essent Fatty Acids 78:343-50. 2008
    ..Overall the data suggest that high exposure to LCPUFAs from habitual fish consumption does not prevent the documented decrease in LCPUFA status in pregnancy that occurs as a result of foetal accretion in the third trimester of pregnancy...
  5. ncbi The impact of EPA and DHA on blood lipids and lipoprotein metabolism: influence of apoE genotype
    Eliz Anil
    Hugh Sinclair Unit of Human Nutrition, Department of Food Biosciences, PO Box 226, University of Reading, Whiteknights, Reading RG6 6AP, UK
    Proc Nutr Soc 66:60-8. 2007
    ..In the present review the impact of EPA and DHA on cardiovascular risk and the blood lipoprotein profile will be considered, with a focus on the apoE gene locus as a possible determinant of lipid responsiveness to fish oil intervention...
  6. pmc Phospholipase A2 activity triggers the wound-activated chemical defense in the diatom Thalassiosira rotula
    Georg Pohnert
    Max Planck Institut für Chemische Okologie, Winzerlaer Strasse 10, D 07745 Jena, Germany
    Plant Physiol 129:103-11. 2002
    ....
  7. ncbi A systematic method for the sensitive and specific determination of hair lipids in combination with chromatography
    Yoshinori Masukawa
    Tochigi Research Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga, Tochigi 321 3497, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 823:131-42. 2005
    ..This method may be useful for clarifying the important roles of intrinsic endogenous 18-MEA, CS, CH and CERs in the function of the cell membrane complex of hair fibers...
  8. ncbi Temperature-related non-homogeneous fatty acid desaturation in sunflower (Helianthus annuus L.) seeds
    Valle Fernández-Moya
    Instituto de la Grasa, Consejo Superior de Investigaciones Cientificas, Av Padre Garcia Tejero 4, 41012 Sevilla, Spain
    Planta 216:834-40. 2003
    ..Other high-stearic-acid mutant lines, such as CAS-3, did not show any gradient. This is the first time that a gradient and an inheritable maternal control of the fatty acid composition have been found in oilseeds...
  9. ncbi Identification and functional characterization of the moss Physcomitrella patens delta5-desaturase gene involved in arachidonic and eicosapentaenoic acid biosynthesis
    Songsri Kaewsuwan
    Department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, 447 Sri Ayudhya Road, Ratchathewi, Bangkok 10400, Thailand
    J Biol Chem 281:21988-97. 2006
    ..In addition, overexpression of the P. patens cDNA in protoplasts isolated from a disrupted line resulted in the restoration of arachidonic acid synthesis...
  10. ncbi Roles of epoxyeicosatrienoic acids in vascular regulation and cardiac preconditioning
    Kathryn M Gauthier
    Department of Pharmacology and Toxicology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    J Cardiovasc Pharmacol 50:601-8. 2007
    ..Production and metabolism of EETs as well as their specific cellular signaling mechanisms are discussed...
  11. ncbi Autoxidative transformation of chiral omega6 hydroxy linoleic and arachidonic acids to chiral 4-hydroxy-2E-nonenal
    Claus Schneider
    Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232, USA
    Chem Res Toxicol 17:937-41. 2004
    ..Our results establish, moreover, that omega6 hydroxy fatty acids are potential precursors of reactive cytotoxic aldehydes in biological systems...
  12. ncbi New galactolipids from the marine bacillariophycean microalga Nitzschia sp
    B W Son
    Department of Chemistry, Pukyong National University, Pusan, Korea
    Nat Prod Lett 15:299-306. 2001
    ....
  13. ncbi Use of nutritional supplements to increase the efficacy of fluoxetine in the treatment of anorexia nervosa
    Nicole C Barbarich
    Department of Psychiatry, University of Pittsburgh Medical School, Anorexia and Bulimia Nervosa Research Module, Pittsburgh, Pennsylvania 15213, USA
    Int J Eat Disord 35:10-5. 2004
    ..However, it may be effective in preventing relapse after weight restoration. The purpose of this study was to determine whether nutritional supplements could potentiate the effects of fluoxetine in underweight AN subjects...
  14. ncbi Inhibition of formyl-methionyl-leucyl-phenylalanine-stimulated respiratory burst in human neutrophils by adrenaline: inhibition of Phospholipase A2 activity but not p47phox phosphorylation and translocation
    Yvonne M O'Dowd
    Department of Biochemistry, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Belfield, 4, Dublin, Ireland
    Biochem Pharmacol 67:183-90. 2004
    ..We suggest that adrenaline inhibits fMLP induced superoxide production upstream of the NADPH oxidase via a mechanism involving PKA and cPLA(2)...
  15. ncbi Serum non-esterified very long-chain PUFA are associated with markers of endothelial dysfunction
    Paula Yli-Jama
    Institute for Nutrition Research, University of Oslo, PO Box 1046, Blindern, N 0316, Oslo, Norway
    Atherosclerosis 164:275-81. 2002
    ..The inverse relation between the levels of sVCAM-1 and very long-chain n-3 fatty acids might indicate an anti-inflammatory effect of the latter...
  16. ncbi Hypocholesterolemic effects of fatty acid bile acid conjugates (FABACs) in mice
    Alicia Leikin-Frenkel
    Minerva Center for Cholesterol Gallstones and Lipid Metabolism in the Liver, Tel Aviv University, Israel
    Arch Biochem Biophys 471:63-71. 2008
    ..In conclusion, FABACs markedly reduce elevated plasma cholesterol in mice by reducing the hepatic synthesis of cholesterol, in conjunction with an increase of its catabolism and excretion from the body...
  17. ncbi Maple syrup urine disease hair reveals the importance of 18-methyleicosanoic acid in cuticular delamination
    James R Smith
    Scanning Probe Microscopy Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael s Building, White Swan Road, Portsmouth PO1 2DT, UK
    Micron 36:261-6. 2005
    ..Cuticular delamination in MSUD-hair probably still occurs within the general plane of the CCMC, although fracture through discontinuities of this layer results in zones of endocuticle being exposed at the new surface...
  18. ncbi Epoxyeicosatrienoic acids, TRP channels, and intracellular Ca2+ in the vasculature: an endothelium-derived endothelium-hyperpolarizing factor?
    Brandon T Larsen
    Arterioscler Thromb Vasc Biol 27:2496-8. 2007
  19. ncbi Cytotoxic compounds of Schizolaena hystrix from the Madagascar rainforest
    Brian T Murphy
    Department of Chemistry, M C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA
    Planta Med 72:1235-8. 2006
    ..Isolation and structure elucidation of the novel compounds and the cytotoxicities of all the isolates are reported...
  20. ncbi Physicochemical properties of the oil from the fruit of Blighia sapida and toxicological evaluation of the oil-based diet in Wistar rats
    A T Oladiji
    Department of Biochemistry, University of Ilorin, Ilorin, Nigeria
    J Med Food 12:1127-35. 2009
    ..It is richer than soybean oil in behenic, palmitoleic, oleic, gadoleic, erucic, and 9,12-eicosanoic acids by 15.70%, 0.89%, 7.22%, 12.05%, 8.27%, and 21.35%, respectively...
  21. ncbi Biological activities of conjugated fatty acids: conjugated eicosadienoic (conj. 20:2delta(c11,t13/t12,c14)), eicosatrienoic (conj. 20:3delta(c8,t12,c14)), and heneicosadienoic (conj. 21:2delta(c12,t14/c13,t15)) acids and other metabolites of conjugated l
    Yeonhwa Park
    Department of Food Science, University of Massachusetts, 100 Holdsworth Way, Amherst, MA 01003, USA
    Biochim Biophys Acta 1687:120-9. 2005
    ..This is the first work to report the presence of conjugated 12 and 14 carbon fatty acids, originated from CLA, and the biological activities of CEA, CETA and CHDA...
  22. ncbi Structural study on polymorphism of long-chain dicarboxylic acids using oblique transmission method for micro FT-IR spectrometers
    Fumitoshi Kaneko
    Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Osaka 560, Japan
    Spectrochim Acta A Mol Biomol Spectrosc 60:9-18. 2004
    ..The result of oblique transmission measurements showed that the stacking mode of lamellae varied depending on crystallization conditions...
  23. pmc Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes
    Haruki Higashimori
    Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, USA
    Am J Physiol Cell Physiol 299:C1068-78. 2010
    ....
  24. ncbi Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids
    Dominik Oliver
    Institute of Physiology, University of Freiburg, Hermann Herder Strabetae 7, 79104 Freiburg, Germany
    Science 304:265-70. 2004
    ..The bidirectional control of Kv channel gating by lipids may provide a mechanism for the dynamic regulation of electrical signaling in the nervous system...
  25. ncbi Effects of oils rich in eicosapentaenoic and docosahexaenoic acids on immune cell composition and function in healthy humans
    Samantha Kew
    Hugh Sinclair Unit of Human Nutrition, School of Food Biosciences, University of Reading, United Kingdom
    Am J Clin Nutr 79:674-81. 2004
    ..However, whether EPA, DHA, or a combination of the 2 exerts these immunomodulatory effects is unclear...
  26. ncbi Analysis of cellular fatty acids in Orientia tsutsugamushi as taxonomic markers
    Soo Kyoung Shim
    Division of Rickettsial and Zoonotic Diseases, Department of Bacteriology, National Institute of Health, Seoul, Korea
    Microbiol Immunol 49:343-7. 2005
    ..34 to 0.54. These results showed that the cellular fatty acid profile should provide more reliable information for the identification of these bacteria...
  27. ncbi [Study on chemical constituents of the essential oil from Myristica fragrans Houtt. by supercritical fluid extraction and steam distillation]
    Qin Qiu
    School of Environmental Science and Engineering, Shandong University, Jinan
    Zhong Yao Cai 27:823-6. 2004
    ..38 compounds were identified for the essential oil obtained by SD, and its main components have been found to be beta-pinene, terpinen-4-ol, alpha-pinene, gamma-terpinene and beta-phellandrene...
  28. ncbi Redberry juniper as a roughage source in lamb feedlot rations: wool and carcass characteristics, meat fatty acid profiles, and sensory panel traits
    T R Whitney
    Texas AgriLife Research, 7887 U S Hwy 87 N, San Angelo, TX 76901, USA
    Meat Sci 89:160-5. 2011
    ..09) and stearic acid linearly decreased (P=0.05) as percentage of juniper increased in the diet. Off-flavor linearly increased (P=0.02) as juniper increased in the diet...
  29. ncbi Very long chain fatty acid synthesis in sunflower kernels
    Joaquin J Salas
    Instituto de la Grasa CSIC, Avenida Padre García Tejero, 4, 41012, Sevilla, Spain
    J Agric Food Chem 53:2710-6. 2005
    ..In light of these results, the VLCFA composition of sunflower oil is considered in relation to that in other commercially exploited oils...
  30. ncbi Risk stratification by the "EPA+DHA level" and the "EPA/AA ratio" focus on anti-inflammatory and antiarrhythmogenic effects of long-chain omega-3 fatty acids
    Heinz Rupp
    Molecular Cardiology Laboratory, Department of Internal Medicine and Cardiology, Philipps University of Marburg, Marburg, Germany
    Herz 29:673-85. 2004
    ..With documented coronary heart disease, it was advised to consume approximately 1 g/day of EPA+DHA...
  31. pmc Attenuation of vascular smooth muscle cell proliferation by 1-cyclohexyl-3-dodecyl urea is independent of soluble epoxide hydrolase inhibition
    Benjamin B Davis
    Division of Nephrology, Department of Internal Medicine, University of California, Davis, 95616, USA
    J Pharmacol Exp Ther 316:815-21. 2006
    ..In addition, our results show that caution should be used when attempting to infer conclusions of EET biology based solely on the effects these inhibitors in tissue culture models, especially when used at micromolar concentrations...
  32. ncbi Sum frequency generation from Langmuir-Blodgett multilayer films on metal and dielectric substrates
    Jasper Holman
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK
    J Phys Chem B 109:18723-32. 2005
    ..The differences in the spectra from the same ten-layer per-protonated films deposited on the two types of hydrophobic substrate have been explained in terms of a simple model that accounts for resonant and nonresonant contributions...
  33. ncbi 15-lipoxygenase-1/15-hydroxyeicosatetraenoic acid promotes hepatocellular cancer cells growth through protein kinase B and heat shock protein 90 complex activation
    Jun Ma
    Department of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University Daqing, Daqing 163319, China
    Int J Biochem Cell Biol 45:1031-41. 2013
    ....
  34. ncbi Insights into the structure of covalently bound fatty acid monolayers on a simplified model of the hair epicuticle from molecular dynamics simulations
    Daniel W Cheong
    Institute of High Performance Computing, Agency for Science, Technology and Research, Connexis, Singapore
    Langmuir 28:13008-17. 2012
    ..To our knowledge, this is the first attempt to systematically investigate the hair surface structure and properties with molecular simulations...
  35. ncbi Three hydroxylated lupeol-based triterpenoid esters isolated from the Eastern Nigeria mistletoe parasitic on Kola acuminata
    Edwin Ogechukwu Omeje
    Department of Pharmaceutical and Medicinal Chemistry, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Nigeria
    Nat Prod Res 26:1775-81. 2012
    ..NOE and NOESY) studies as 7β,15α-dihydroxyl-lup-20(29)-ene-3β-esters of palmitic (I), stearic (II) and eicosanoic acids (III). The characterisation of other isolated compounds is ongoing...
  36. ncbi Docosahexaenoic acid elevates trans-18:1 isomers but is not directly converted into trans-18:1 isomers in ruminal batch cultures
    C M Klein
    Department of Animal Science, Clemson University, Clemson, SC 29634 0311, USA
    J Dairy Sci 94:4676-83. 2011
    ..These studies showed that trans-18:1 fatty acids are not produced from DHA, supporting that DHA elevates trans-18:1 by modifying biohydrogenation pathways of other polyunsaturated fatty acids...
  37. ncbi The thickness of 18-MEA on an ultra-high-sulfur protein surface by molecular modeling
    Upendra Natarajan
    Molecular Modeling and Simulation Lab, Department of Chemical Engineering, Indian Institute of Technology, Madras, Chennai 600036, India
    J Cosmet Sci 61:467-77. 2010
    ..5). The beta sheets of this model provide an intersheet spacing of 0.7 nm and a beta sheet density of 1.42 g/cm(3) compared with Allworden membrane fractions that varied from 1.39 to 1.54 g/cm(3) (6)...
  38. ncbi Characterization of a KCS-like KASII from Jessenia bataua that elongates saturated and monounsaturated stearic acids in Arabidopsis thaliana
    Ooi Kock Teh
    Malaysian Palm Oil Board Advanced Biotechnology and Breeding Centre, No 6, Persiaran Institusi, Bandar Baru Bangi, 43000, Kajang, Selangor, Malaysia
    Mol Biotechnol 48:97-108. 2011
    ..JbKASII may, therefore, be an interesting candidate gene for promoting the production of very long chain fatty acids in transgenic oil crops...
  39. ncbi Screening assay of very long chain fatty acids in human plasma with multiwalled carbon nanotube-based surface-assisted laser desorption/ionization mass spectrometry
    Wei Yi Hsu
    Department of Medical Research, China Medical University Hospital, Taichung, Taiwan
    Anal Chem 82:6814-20. 2010
    ..In addition, this method does not require liquid/gas chromatography separation, thereby allowing for high-throughput screening of VLCFAs in peroxisomal disorders...
  40. ncbi Deposition of 18-MEA onto alkaline-color-treated weathered hair to form a persistent hydrophobicity
    Hiroto Tanamachi
    Beauty Research Center, Kao Corporation, 2 1 3, Bunka, Sumida ku, Tokyo 131 8501, Japan
    J Cosmet Sci 60:31-44. 2009
    ..The results revealed that 18-MEA/SPDA formed a layer with high wear resistance, with an alkyl chain, the hydrophobic moiety, oriented at an angle of around 25 degrees to the air interface...
  41. ncbi Structure of the buried metal-molecule interface in organic thin film devices
    Christian R Hansen
    Danish National Research Foundations Centre for Molecular Movies, Nano Science Center, Niels Bohr Institute, and Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK 2100, Denmark
    Nano Lett 9:1052-7. 2009
    ..We find that the organized structure of the two topmost LB layers (approximately 5 nm) is completely destroyed due to the metal deposition...
  42. pmc Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C ε-mediated zona occludens-1 phosphorylation at threonine 770/772
    Rima Chattopadhyay
    From the Department of Physiology, University of Tennessee Health Science Center, Memphis, Tennessee 38163
    J Biol Chem 289:3148-63. 2014
    ....
  43. ncbi Epoxygenases and peroxisome proliferator-activated receptors in mammalian vascular biology
    Jessica Wray
    Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary University London, Charterhouse Square, London EC1M 6BQ, UK
    Exp Physiol 93:148-54. 2008
    ..The epoxygenase-EET-PPAR pathway may therefore represent a novel endogenous protective pathway by which short-lived lipid mediators control vascular cell activation...
  44. ncbi Epoxyeicosatrienoic acids regulate Trp channel dependent Ca2+ signaling and hyperpolarization in endothelial cells
    Ingrid Fleming
    Vascular Signalling Group, Institut für Kardiovaskuläre Physiologie, Johann Wolfgang Goethe Universitat, Theodor Stern Kai 7, D 60590 Frankfurt am Main, Germany
    Arterioscler Thromb Vasc Biol 27:2612-8. 2007
    ..Here we address the mechanisms by which cytochrome P450 (CYP)-derived epoxyeicosatrienoic acids (EETs) contribute to this effect in native and cultured endothelial cells...
  45. ncbi Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults
    Ralf Schubert
    Department of Pediatrics, J W Goethe University, Frankfurt Main, Germany
    Nutrition 23:724-30. 2007
    ....
  46. ncbi Ceramide kinase uses ceramide provided by ceramide transport protein: localization to organelles of eicosanoid synthesis
    Nadia F Lamour
    Department of Biochemistry, Medical College of Virginia, Virginia Commonwealth University, Richmond, VA 23298, USA
    J Lipid Res 48:1293-304. 2007
    ..In conclusion, these results demonstrate that CERK localizes to areas of eicosanoid synthesis and uses a ceramide "pool" transported in an active manner via CERT...
  47. ncbi What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
    G Furstenberger
    Research Group Eicosanoids and Tumor Development, Deutsches Krebsforschungszentrum Heidelberg, D 69120 Heidelberg, Germany
    Int J Cancer 119:2247-54. 2006
    ..e., the 5- and platelet-type 12-lipoxygenase exhibit procarcinogenic activities, while 15-lipoxygenase-1 and 15-lipoxygenase-2 may suppress carcinogenesis...
  48. ncbi Structures of langmuir-gibbs films consisting of long-chain fatty acid and water-soluble surfactants
    Kenichiro Oka
    Department of Materials Science and Technology, Faculty of Industrial Science, Tokyo University of Science, Tokyo, Japan
    J Oleo Sci 62:681-93. 2013
    ..In some cases, the multilayers were kinetically stabilized and were present even 24 h after the injection of the water-soluble surfactants into the subphase. ..
  49. ncbi Surface-enhanced resonance raman scattering: single-molecule detection in a Langmuir-Blodgett monolayer
    Carlos J L Constantino
    Depto de Física, Química e Biologia, FCT UNESP, CP 467, 19060 900, Presidente Prudente, SP, Brazil
    Appl Spectrosc 57:649-54. 2003
    ..The dilution process used in the single-molecule LB SERRS work is independently supported by fluorescence results obtained from very dilute solutions with monomer concentrations down to 10(-12) M...
  50. ncbi Phospholipase A2 in the central nervous system: implications for neurodegenerative diseases
    Grace Y Sun
    Department of Biochemistry, University of Missouri, Columbia, MO 65211, USA
    J Lipid Res 45:205-13. 2004
    ..Information from these studies has provided clear evidence for the important role of PLA2 in regulating physiological and pathological functions in the CNS...
  51. ncbi Leukotrienes levels in the aqueous humor following experimental ocular trauma
    L Latanza
    Department of Ophthalmology, New York Hospital Cornell Medical Center, New York 10021
    Retina 8:199-204. 1988
    ..These data demonstrate that elevations in LTB4 and LTC4 are associated with blunt trauma, and this precedes PMN cell infiltration. Leukotrienes may play a role in the early inflammatory response following concussive ocular injuries...
  52. pmc Effect of cholera toxin on the production of eicosanoids by rat jejunum
    G Autore
    Department of Experimental Pharmacology, University of Naples, Italy
    Br J Pharmacol 92:149-52. 1987
    ..v. cholera toxin. Pretreatment with indomethacin reduced the production of PGE2. 3 These findings are consistent with the hypothesis that arachidonate metabolites are involved in the diarrhoea induced by cholera toxin...
  53. ncbi Influence of dietary cis and trans fats on DMH-induced colon tumors, steroid excretion, and eicosanoid production in rats prone to colon cancer
    M Sugano
    Laboratory of Nutrition Chemistry, Kyushu University School of Agriculture, Fukuoka, Japan
    Nutr Cancer 12:177-87. 1989
    ..Thus, trans fat behaved much like the cis fat in various parameters, except for steroid excretion...
  54. ncbi Membrane fatty acid composition and endothelial cell functional properties
    R C Vossen
    Department of Biochemistry, University of Limburg, Maastricht, The Netherlands
    Biochim Biophys Acta 1083:243-51. 1991
    ..This study demonstrates that considerable changes in membrane fatty acid profile affect endothelial cell arachidonic acid metabolism, but it also illustrates homeostasis at the level of endothelial cell functional activity...
  55. pmc Effect of arachidonic and eicosapentaenoic acids on acute lung injury induced by hypochlorous acid
    H Wahn
    Medizinische Universitätsklinik Würzburg, Germany
    Thorax 57:1060-6. 2002
    ..This study investigates the effects of HOCl on pulmonary artery pressure (PAP) and vascular permeability and characterises the influence of arachidonic acid (AA) and eicosapentaenoic acid (EPA) on the observed effects...
  56. ncbi Generation and metabolism of lipoxygenase products in normal and membrane-damaged cultured human keratinocytes
    F A Green
    Department of Medicine, State University of New York, Buffalo
    J Invest Dermatol 93:486-91. 1989
    ....
  57. ncbi Differential modulation of NMDA-induced calcium transients by arachidonic acid and nitric oxide in cultured hippocampal neurons
    D A Richards
    Division of Neurophysiology, National Institute for Medical Research, Mill Hill, London NW7 1AA, UK
    Eur J Neurosci 17:2323-8. 2003
    ..Therefore two substances implicated in synaptic plasticity (arachidonic acid and nitric oxide) differentially modulate NMDA-mediated Ca2+ entry into hippocampal neurons...
  58. ncbi Saturated triglycerides and fatty acids activate neutrophils depending on carbon chain-length
    G J A Wanten
    Department of Gastroenterology and Hepatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Eur J Clin Invest 32:285-9. 2002
    ..Furthermore we tested the hypothesis that carbon-chain length is of importance in this respect...
  59. ncbi Clinical and biochemical heterogeneity in conditions with phytanic acid accumulation
    O H Skjeldal
    J Neurol Sci 77:87-96. 1987
    ..The distinction between Refsum's disease and the peroxisomal disorders can easily be done on a clinical basis...
  60. ncbi Exhaled eicosanoid profiles in children with atopic asthma and healthy controls
    Edyta Glowacka
    University Children Hospital, Krakow, ul Wielicka, Poland
    Pediatr Pulmonol 48:324-35. 2013
    ..The aim of this study was to compare the content and profile of a wider range of eicosanoids in the EBC between patients and a control group...
  61. ncbi Amorphous iron-(hydr) oxide networks at liquid/vapor interfaces: in situ X-ray scattering and spectroscopy studies
    Wenjie Wang
    Ames Laboratory, Department of Physics and Astronomy, Iowa State University, Ames, IA 50011, USA
    J Colloid Interface Sci 384:45-54. 2012
    ..Controlling the oxidation of Fe (II) changes the nature and amount of binding significantly. The implications to biomineralization of iron (hydr) oxides are briefly discussed...
  62. ncbi Eicosadienoic acid differentially modulates production of pro-inflammatory modulators in murine macrophages
    Yung Sheng Huang
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan
    Mol Cell Biochem 358:85-94. 2011
    ..Furthermore, EDA was a weaker pro-inflammatory agent than LA, and not as anti-inflammatory as SCA. This study shows that EDA can modulate the metabolism of PUFA and alter the responsiveness of macrophages to inflammatory stimulation...
  63. ncbi Spectroscopic study of fluorescent naphthoylenebenzimidazole derivatives in Langmuir-Blodgett films: self-aggregates formation
    D Bauman
    Faculty of Technical Physics, Poznan University of Technology, 60 965 Poznan, Nieszawska 13A, Poland
    Spectrochim Acta A Mol Biomol Spectrosc 73:668-75. 2009
    ..In the ground electronic state some fraction of the I- and J-type aggregates have been created, whereas in the excited state the creation of genuine excimers has been observed...
  64. ncbi Activated neutrophils release mediators that may contribute to myocardial injury and dysfunction associated with ischemia and reperfusion
    K M Mullane
    Research Department, CIBA GEIGY Corporation, Summit, New Jersey 07901
    Ann N Y Acad Sci 524:103-21. 1988
    ....
  65. pmc An alternate pathway to long-chain polyunsaturates: the FADS2 gene product Delta8-desaturates 20:2n-6 and 20:3n-3
    Woo Jung Park
    Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    J Lipid Res 50:1195-202. 2009
    ..These findings provide unequivocal molecular evidence for a novel alternative biosynthetic route to long-chain polyunsaturated fatty acids in mammals from substrates previously considered to be dead-end products...
  66. ncbi The role of eicosanoids in paediatrics
    H W Seyberth
    , Heidelberg, Federal Republic of Germany
    Eur J Pediatr 147:341-9. 1988
    ..Before active intervention, however, more and specific biochemical analyses are required to identify the pathophysiological role of eicosanoid...
  67. ncbi Dietary linoleic acid has no effect on arachidonic acid, but increases n-6 eicosadienoic acid, and lowers dihomo-gamma-linolenic and eicosapentaenoic acid in plasma of adult men
    Y Angela Liou
    Nutrition Research Program, Child and Family Research Institute, Department of Paediatrics, University of British Columbia, 950 West 28th Avenue, Vancouver, B C, V5Z 4H4, Canada
    Prostaglandins Leukot Essent Fatty Acids 80:201-6. 2009
    ..8% energy, and they suggest current LA intakes saturate Delta-6 desaturation and adversely affect n-3 fatty acid metabolism. Factors other than n-6 fatty acid intake are important modifiers of plasma ARA...
  68. ncbi Soluble epoxide hydrolase inhibitor, AUDA, prevents early salt-sensitive hypertension
    Jing Li
    Department of Pharmacology, New York Medical College, Valhalla, New York 10595, USA
    Front Biosci 13:3480-7. 2008
    ..sEH inhibition may provide a therapeutic strategy for treating salt-sensitive hypertension and its sequelae...
  69. pmc Chemically alternating Langmuir-Blodgett thin films as a model for molecular depth profiling by mass spectrometry
    Leiliang Zheng
    Department of Chemistry, The Pennsylvania State University, University Park 16802, USA
    J Am Soc Mass Spectrom 19:96-102. 2008
    ..The results show the potential of LB films as an experimental model system for studying fundamental features of molecular depth profiling...
  70. ncbi Selectivity of neutrophil 5-lipoxygenase and cyclo-oxygenase inhibition by an anti-inflammatory flavonoid glycoside and related aglycone flavonoids
    M A Moroney
    Department of Pharmacology, King s College, Strand, London, UK
    J Pharm Pharmacol 40:787-92. 1988
    ..These results are discussed in relation to possible mechanisms of hypolaetin-8-glucoside's protective actions and the concept that these inhibitory effects of flavonoids cannot be ascribed to a unitary free radical scavenging action...
  71. ncbi [A new chemical component of Pueraria lobata (Willd.) Ohwi]
    Yan Zhi Wang
    School of Pharmacy, Henan College of Traditional Chinese Medicine, Zhengzhou 450008, China
    Yao Xue Xue Bao 42:964-7. 2007
    ..Compound 1 was a new compound, and compounds 2, 3, 4 were isolated from this plant for the first time...
  72. ncbi Study of assembly of arachidic acid/LDHs hybrid films containing photoactive dyes
    Jun Wang
    Key Laboratory for Colloid and Interface Chemistry of Education Ministry, Shandong University, Jinan, Shandong 250100, People s Republic of China
    J Colloid Interface Sci 318:337-47. 2008
    ..Also, the dye molecules incorporated into AA/LDHs films exhibit excellent configuration stability under the irradiation of UV light because the LDHs matrix offers a more rigid and constrained environment for them...
  73. ncbi Healthy hair: what is it?
    Rodney D Sinclair
    Department of Dermatology St Vincent s Hospital, The Skin and Cancer Foundation of Victoria and The University of Melbourne, Victoria, Australia
    J Investig Dermatol Symp Proc 12:2-5. 2007
    ..Hair products that improve the structural integrity of hair fibers and increase tensile strength are available, as are products that increase hair volume, reduce frizz, improve hair manageability, and stimulate new hair growth...
  74. pmc Effects of non-steroidal anti-inflammatory drugs on rat gastric mucosal leukotriene C4 and prostanoid release: relation to ethanol-induced injury
    B M Peskar
    Department of Experimental Clinical Medicine, Ruhr University of Bochum
    Br J Pharmacol 93:937-43. 1988
    ..These results suggest that there is a causal relationship between enhanced LTC4 biosynthesis and the development of ethanol-induced gastric injury...
  75. ncbi Identification of a novel fatty acid elongase with a wide substrate specificity from arachidonic acid-producing fungus Mortierella alpina 1S-4
    Eiji Sakuradani
    Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Kitashirakawa Oiwakecho, Sakyo ku, Kyoto, 606 8502, Japan
    Appl Microbiol Biotechnol 84:709-16. 2009
    ..The enzyme encoded by MALCE1 was demonstrated to be involved in the conversion of hexadecanoic acid to octadecanoic acid, its main role in M. alpina 1S-4...
  76. pmc Fast diffusion of very long chain saturated fatty acids across a bilayer membrane and their rapid extraction by cyclodextrins: implications for adrenoleukodystrophy
    Biju K Pillai
    Department of Biophysics and Physiology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    J Biol Chem 284:33296-304. 2009
    ..Because VLCFA diffuse through the lipid bilayer, proteins may not be required for their transport across the peroxisomal membrane...
  77. pmc Release of arachidonic acid metabolites and histamine from sensitized guinea-pig lung following antigen challenge
    N C Turner
    Department of Clinical Pharmacology, Royal Postgraduate Medical School, London
    Br J Pharmacol 93:751-8. 1988
    ....
  78. ncbi Eicosanoid release as laboratory indicator of biocompatibility
    A Mahiout
    Department of Nephrology, Free University Berlin, F R G
    Artif Organs 13:251-4. 1989
    ..Thus, the question arises as to whether or not the extracorporeal process of cyclooxygenase activity could contribute to the clinical side effects of chronical hemodialysis...
  79. ncbi The ocular effects of eicosanoids and other autacoids: historic background and the need for a broader perspective
    J Stjernschantz
    Pharmacia Ophthalmics AB, Uppsala, Sweden
    Prog Clin Biol Res 312:1-13. 1989
    ..However, in view of the foregoing, we must resist the temptation to extrapolate to primates results obtained only from studies of rabbit eyes.(ABSTRACT TRUNCATED AT 400 WORDS)..
  80. ncbi Essential fatty acid status in teenage girls with eating disorders and weight loss
    I Swenne
    Department of Women s and Children s Health, Uppsala University, Sweden
    Acta Paediatr 100:762-7. 2011
    ..To explore the relationship between essential fatty acids (FA) and weight changes in adolescent girls with eating disorders (ED)...
  81. pmc Epoxyeicosatrienoic acids enhance axonal growth in primary sensory and cortical neuronal cell cultures
    Emun Abdu
    Department of Neurological Surgery, Oregon Health and Science University, Portland, Oregon, USA
    J Neurochem 117:632-42. 2011
    ..These data indicate that EETs enhance axon outgrowth and suggest that axonal sEH activity regulates EETs-induced axon outgrowth. These findings suggest a novel therapeutic use of sEH inhibitors in promoting nerve regeneration...
  82. ncbi Mechanistic studies of the dioxygenase and leukotriene synthase activities of the porcine leukocyte 12S-lipoxygenase
    A R Brash
    Department of Pharmacology, Vanderbilt University Medical School, Nashville, Tennessee 37232
    Arch Biochem Biophys 273:414-22. 1989
    ..It appears that the porcine leukocyte 12S-lipoxygenase synthesizes 8S,15S-DiHPETE by a different mechanism...
  83. ncbi The role of prenucleation clusters in surface-induced calcium phosphate crystallization
    Archan Dey
    Laboratory of Materials and Interface Chemistry and Soft Matter CryoTEM Unit, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Nat Mater 9:1010-4. 2010
    ..Here we demonstrate that the surface-induced formation of apatite from simulated body fluid starts with the aggregation of prenucleation clusters leading to the nucleation of ACP before the development of oriented apatite crystals...
  84. ncbi Inhibition of DNA topoisomerases I and II and cytotoxicity of compounds from Ulmus davidiana var. japonica
    Ming Shan Zheng
    College of Pharmacy, Yeungnam University, Gyongsan, 712 749, Korea
    Arch Pharm Res 33:1307-15. 2010
    ..3 μM). Compounds 6, 12 and 23 showed cytotoxicities in the HT-29 cell line (IC(50): 19, 19 and 15 μM, respectively, with IC(50) of camptothecin: 2 μM)...
  85. ncbi Effect of the covalently linked fatty acid 18-MEA on the nanotribology of hair's outermost surface
    Steven Breakspear
    Scanning Probe Microscopy Laboratory, School of Pharmacy and Biomedical Sciences, University of Portsmouth, St Michael s Building, White Swan Road, Portsmouth PO1 2DT, UK
    J Struct Biol 149:235-42. 2005
    ....
  86. ncbi Advances in eicosanoid research, novel therapeutic implications
    Jesper Z Haeggstrom
    Department of Medical Biochemistry and Biophysics, Division of Chemistry 2, Karolinska Institutet, S 17177 Stockholm, Sweden
    Biochem Biophys Res Commun 396:135-9. 2010
    ..Emphasis will be placed on structure and receptor biology, which are of significant pharmacological and clinical relevance...
  87. ncbi Phosphatidylglucoside forms specific lipid domains on the outer leaflet of the plasma membrane
    Motohide Murate
    RIKEN Advanced Science Institute, Saitama, Japan
    Biochemistry 49:4732-9. 2010
    ..Our results suggest that the lack of tight intermolecular interaction excludes PtdGlc from other lipid domains on the plasma membrane...
  88. ncbi Phytochemical investigation of the fruit peels of Citrus reticulata Blanco
    M Aasim Khan
    Phytochemistry Research Laboratory, Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard University, New Delhi, India
    Nat Prod Res 24:610-20. 2010
    ....
  89. ncbi Eicosanoids in human ventricular cerebrospinal fluid following severe brain injury
    J Y Westcott
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver 80262
    Prostaglandins 34:877-87. 1987
    ..Thus, elevated free arachidonic acid and various oxygenated metabolites were observed in CSF following brain injury...
  90. ncbi The roles of long-chain polyunsaturated fatty acids in pregnancy, lactation and infancy: review of current knowledge and consensus recommendations
    Berthold Koletzko
    Department of Pediatrics, University of Munich, Munchen, Germany
    J Perinat Med 36:5-14. 2008
    ..Dietary LC-PUFA supply should continue after the first six months of life, but currently there is not sufficient information for quantitative recommendations...
  91. ncbi Eicosanoids and hypoxic pulmonary vasoconstriction in normal man
    R Naeije
    Respiratory Research Unit, Erasme University Hospital, Brussels, Belgium
    Bull Eur Physiopathol Respir 23:613-7. 1987
    ....
  92. ncbi [Recent progress in leukotriene research]
    Takahide Nagase
    Department of Respiratory Medicine, University of Tokyo
    Arerugi 53:1184-6. 2004
  93. ncbi Activation of peroxisome proliferator-activated receptor (PPAR)-gamma by 15S-hydroxyeicosatrienoic acid parallels growth suppression of androgen-dependent prostatic adenocarcinoma cells
    Hung Pham
    Department of Dermatology, School of Medicine, University of California Davis, Davis, CA 95616, USA
    Cancer Lett 189:17-25. 2003
    ..The data, taken together, suggest that dietary GLA via its in vivo metabolite 15S-HETrE could serve as an endogenous adjunct to attenuate prostatic tumorigenesis...
  94. ncbi Hypoxic preconditioning and tolerance via hypoxia inducible factor (HIF) 1alpha-linked induction of P450 2C11 epoxygenase in astrocytes
    Mingyue Liu
    Department of Anesthesiology and Critical Care, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Cereb Blood Flow Metab 25:939-48. 2005
    ..HPC and EETs reduced astrocyte cell death, and P450 epoxygenase inhibition prevented protection by HPC. We conclude that HPC induces tolerance in astrocytes, at least in part, via HIF-1alpha-linked upregulation of P450 2C11...
  95. ncbi Inflammatory mediators induced by coarse (PM2.5-10) and fine (PM2.5) urban air particles in RAW 264.7 cells
    Roberta Pozzi
    Laboratory of Environmental Hygiene, Istituto Superiore di Sanita, Viale Regina Elena 299, 00161 Rome, Italy
    Toxicology 183:243-54. 2003
    ..5 and by PM2.5-10 but not by carbon black. Carbon black was consistently less effective than the urban particles, suggesting that, the contaminants adsorbed on the particles are responsible for the release of inflammatory mediators...
  96. ncbi In vitro effects of eicosanoids derived from different 20-carbon Fatty acids on production of monocyte-derived cytokines in human whole blood cultures
    E A Miles
    Institute of Human Nutrition, University of Southampton, Southampton, UK
    Cytokine 20:215-23. 2002
    ..Methods Human whole blood was diluted 1:5 and incubated for 48h with lipopolysaccharide. PGE and LT were added and the concentrations of inflammatory cytokines in the cell culture supernatants determined...
  97. ncbi Triacylglycerol molecular species are depleted to different extents in the myocardium of spontaneously hypertensive rats fed two oleic acid-rich oils
    Javier S Perona
    Departamento de Caracterización y Calidad de los Alimentos, Instituto de la Grasa CSIC, Seville, Spain
    Am J Hypertens 18:72-80. 2005
    ....
  98. ncbi Transcription of T7 DNA immobilised on latex beads and Langmuir-Blodgett film
    Debalina Ghosh
    Molecular Biophysics Unit, Indian Institute of Science, Bangalore 560012, India
    J Biochem Biophys Methods 62:51-62. 2005
    ..These immobilized DNAs were used as a template to study in vitro transcription reaction and thus we introduce a new strategy for the study of transcription in heterogeneous phase...
  99. ncbi Biosynthesis of epoxyeicosatrienoic acids varies between polymorphic CYP2C enzymes
    Mia Sandberg Lundblad
    Karolinska Institutet, Division of Clinical Pharmacology, Karolinska University Hospital, Huddinge, SE 141 86 Stockholm, Sweden
    Biochem Biophys Res Commun 327:1052-7. 2005
    ..1 had lower K(m) than these isoforms. In conclusion, there are genetic differences in the CYP2C-dependent oxidation of arachidonic acid to vasoactive metabolites, of which the relevance to cardiovascular pathophysiology is still unclear...
  100. ncbi [Study of supercritical-CO2 fluid extraction in extracting essential oils of Amomun tsao-ko]
    Y Wu
    Guangzhou Pharmaceutical Industrial Research Institute, Guangzhou 510240
    Zhong Yao Cai 20:240-1. 1997
    ..1, 8-cineole, trans-geraniol eicosatrienoic acid methylester and d-nerolidol of them are the major constitutents, 12 constitutents of them are first obtained from the plant...
  101. ncbi Acyl chain-based molecular selectivity for HL60 cellular phosphatidylinositol and of phosphatidylcholine by phosphatidylinositol transfer protein alpha
    Alan N Hunt
    Division of Infection, Inflammation and Repair, School of Medicine, University of Southampton, Southampton SO16 6YD, UK
    Biochim Biophys Acta 1686:50-60. 2004
    ..This is consistent with target cell membranes actively remodelling newly delivered phospholipids after transport rather than relying on the transport of the specific molecular species conventionally found in mammalian membranes...

Research Grants4

  1. EICOSANOIC ACIDS IN TRYPANOSOMA BRUCEI
    LAWRENCE RUBEN; Fiscal Year: 2002
    ..During the course of studies on the control of Ca+ currents in T. brucei, they discoved key components of an eicosanoic acid pathway. The present proposal will examine how trypanosomes regulate Ca+/eicosanoic acid signals. ..
  2. Mechanisms of resistance artery contraction
    JOSEPH ELLIOTT BRAYDEN; Fiscal Year: 2010
    ..abstract_text> ..
  3. Conference on Oxidative Mechanisms in Neurodegeneration
    Grace Sun; Fiscal Year: 2004
    ..In addition, plans are in progress to provide rapid publication of the symposium proceedings in an internationally recognized neuroscience journal. ..
  4. Function and regulation of cardiac Na transporters
    Donald Hilgemann; Fiscal Year: 2008
    ..4) In parallel with the experimental program, we will develop improved mathematical models of cardiac ion homeostasis with an emphasis on these three Na transporters. ..