octanoic acids

Summary

Top Publications

  1. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
  2. pmc Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 118:1100-8. 2010
  3. ncbi Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
  4. pmc The C8 health project: design, methods, and participants
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9105, USA
    Environ Health Perspect 117:1873-82. 2009
  5. pmc Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, California 95616, USA
    Environ Health Perspect 119:1760-5. 2011
  6. ncbi Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals
    Naomi Kudo
    Department of Toxicology and Applied Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Toxicol Sci 28:49-57. 2003
  7. pmc Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population
    Jessica W Nelson
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:197-202. 2010
  8. ncbi Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha
    Jamie C DeWitt
    East Carolina University, Greenville, North Carolina, USA
    Crit Rev Toxicol 39:76-94. 2009
  9. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
  10. pmc Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia
    Scott M Bartell
    Program in Public Health, University of California, Irvine, California 92697 1250, USA
    Environ Health Perspect 118:222-8. 2010

Research Grants

  1. A Temporal-Spatial Analysis of Breast Cancer in Upper C*
    Veronica Vieira; Fiscal Year: 2006
  2. Community Exposure to Perfluorooctanate
    Edward Emmett; Fiscal Year: 2006
  3. Focal Brain Ischemia in the TNF-alpha-Transgenic Rat
    L Pettigrew; Fiscal Year: 2007
  4. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
  5. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
  6. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
  7. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
  8. LIPID METABOLISM IN FAT CELLS
    Wen Guo; Fiscal Year: 2010
  9. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
  10. IRON, ZINC AND FOLATE AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2001

Detail Information

Publications226 found, 100 shown here

  1. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
    ..The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals...
  2. pmc Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Environ Health Perspect 118:1100-8. 2010
    ..OBJECTIVE AND SOURCES: We reviewed the epidemiologic literature for PFOA...
  3. ncbi Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
    Kayoko Kato
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
    Environ Sci Technol 45:8037-45. 2011
    ..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure...
  4. pmc The C8 health project: design, methods, and participants
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9105, USA
    Environ Health Perspect 117:1873-82. 2009
    ..The settlement stemmed from the perfluorooctanoic acid (PFOA, or C8) contamination of drinking water in six water districts in two states near the DuPont Washington Works facility near Parkersburg, West Virginia...
  5. pmc Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project
    Hyeong Moo Shin
    School of Social Ecology, University of California, Irvine, California 95616, USA
    Environ Health Perspect 119:1760-5. 2011
    ..People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities...
  6. ncbi Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals
    Naomi Kudo
    Department of Toxicology and Applied Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    J Toxicol Sci 28:49-57. 2003
    ..Elucidation of the mechanisms of transport in biological systems leads to elimination and detoxification of this chemical in the human body...
  7. pmc Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population
    Jessica W Nelson
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:197-202. 2010
    ..Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation...
  8. ncbi Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha
    Jamie C DeWitt
    East Carolina University, Greenville, North Carolina, USA
    Crit Rev Toxicol 39:76-94. 2009
    ..This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPARalpha ligands of therapeutic and environmental interest...
  9. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  10. pmc Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia
    Scott M Bartell
    Program in Public Health, University of California, Irvine, California 92697 1250, USA
    Environ Health Perspect 118:222-8. 2010
    ..Two highly contaminated water districts began granular activated carbon filtration in 2007...
  11. pmc Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 116:1391-5. 2008
    ..Animal studies have shown that they may affect neuromuscular development at high concentrations...
  12. ncbi Ammonium perfluorooctanoate production and occupational mortality
    Jessica I Lundin
    Division of Environmental Health Sciences, University of Minnesota, School of Public Health, Minneapolis, MN 55455, USA
    Epidemiology 20:921-8. 2009
    ..Perfluorooctanoate (PFOA) is a synthetic chemical widely detectable in blood of nonoccupationally exposed persons. Its human health effects are not well-characterized...
  13. pmc Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1596-602. 2007
    ..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably...
  14. ncbi Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain
    Niclas Johansson
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicol Sci 108:412-8. 2009
    ..These proteins are important for normal brain development, and altered levels of these proteins during a critical period of the brain growth spurts could be one of the mechanisms behind earlier reported behavioral defects...
  15. pmc Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth
    Noriaki Washino
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Environ Health Perspect 117:660-7. 2009
    ..Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent...
  16. ncbi Pre- and postnatal exposure to perfluorinated compounds (PFCs)
    Hermann Fromme
    Department of Chemical Safety and Toxicology Biomonitoring, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D 80538 Munich, Germany
    Environ Sci Technol 44:7123-9. 2010
    ..Although the concentrations in breast milk were low, this intake led to a body burden at the age of six months similar to (PFOS) or higher than (PFOA) that found in adults...
  17. ncbi Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis
    Jessica Berthiaume
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, 10 University Drive, Duluth, MN 55812 2496, USA
    Toxicol Lett 129:23-32. 2002
    ..These data demonstrate that acute administration of PFOS or PFOA causes hepatic peroxisome proliferation in rats. However, stimulation of mt biogenesis is not a characteristic response of all peroxisome proliferators...
  18. ncbi Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
    ..Important issues are addressed regarding the methods and data analysis that may limit inferences from this particular study...
  19. ncbi Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis
    Lin Cui
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Arch Environ Contam Toxicol 56:338-49. 2009
    ..The definite toxicity and high accumulation of the tested PFCs might pose a great threat to biota and human beings due to their widespread application in various fields...
  20. pmc Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey
    David Melzer
    Epidemiology and Public Health Group, eninsula Medical School, Exeter, United Kingdom
    Environ Health Perspect 118:686-92. 2010
    ..Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health...
  21. ncbi Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant
    Kyle Steenland
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 170:1268-78. 2009
    ..Because these data are cross-sectional, causal inference is limited. Nonetheless, the associations between these compounds and lipids raise concerns, given their common presence in the general population...
  22. ncbi Determinants of plasma PFOA and PFOS levels among 652 Danish men
    Kirsten T Eriksen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Sci Technol 45:8137-43. 2011
    ..Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation...
  23. ncbi Perfluorooctanoate and perfluorooctanesulfonate plasma levels and risk of cancer in the general Danish population
    Kirsten T Eriksen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark
    J Natl Cancer Inst 101:605-9. 2009
    ..99 to 1.93). Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate in the general Danish population appear not to be associated with risk of prostate, bladder, pancreatic, or liver cancer...
  24. ncbi Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  25. ncbi Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
    J A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA
    Toxicology 288:8-17. 2011
    ....
  26. pmc Differential effects of peripubertal exposure to perfluorooctanoic acid on mammary gland development in C57Bl/6 and Balb/c mouse strains
    Chengfeng Yang
    Department of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Reprod Toxicol 27:299-306. 2009
    ..This underscores the need for caution when drawing conclusions about the effects of PFOA and possibly other environmental pollutants on the basis of studies in a single mouse strain...
  27. ncbi Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice
    N Johansson
    Department of Environmental Toxicology, Uppsala University, Norbyvägen 18 A, S 752 36 Uppsala, Sweden
    Neurotoxicology 29:160-9. 2008
    ..These developmental neurotoxic effects are similar to those we reported earlier for PCBs and PBDEs. This suggests that PFOS and PFOA be included in the group of POPs known to be developmental neurotoxicants...
  28. pmc Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 118:229-33. 2010
    ..PFOA has been associated with elevated uric acid in two studies of chemical workers. Uric acid is a risk factor for hypertension and possibly other cardiovascular outcomes...
  29. pmc Relationships of perfluorooctanoate and perfluorooctane sulfonate serum concentrations between mother-child pairs in a population with perfluorooctanoate exposure from drinking water
    Debapriya Mondal
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Environ Health Perspect 120:752-7. 2012
    ..This study provides an opportunity to assess the association between PFAA concentrations in mother-child pairs in a population exposed to PFOA via drinking water...
  30. pmc Developmental neurotoxicity of perfluorinated chemicals modeled in vitro
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 116:716-22. 2008
    ..The widespread detection of perfluoroalkyl acids and their derivatives in wildlife and humans, and their entry into the immature brain, raise increasing concern about whether these agents might be developmental neurotoxicants...
  31. ncbi Maternal levels of perfluorinated chemicals and subfecundity
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, University of California Los Angeles, PO Box 951772, 71 254 CHS, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Hum Reprod 24:1200-5. 2009
    ..Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are ubiquitous man-made compounds that are possible hormonal disruptors. We examined whether exposure to these compounds may decrease fecundity in humans...
  32. pmc Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults
    Chien Yu Lin
    Department of Internal Medicine of Nephrology, En Chu Kong Hospital, Taipei County, Taiwan
    Diabetes Care 32:702-7. 2009
    ..Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known...
  33. ncbi Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation
    Cathrine Thomsen
    Department of Analytical Chemistry, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Sci Technol 44:9550-6. 2010
    ..There were no significant differences in isomer pattern between the mothers, or changes during the lactation period. After a year of nursing the breast-milk concentrations of PFCs, PBDEs, and PCBs were reduced by 15-94%...
  34. ncbi Simultaneous accumulation and degradation of polyhydroxyalkanoates: futile cycle or clever regulation?
    Qun Ren
    Laboratory of Biomaterials, Swiss Federal Laboratories for Materials Testing and Research Empa, CH 9014 St Gallen, Switzerland
    Biomacromolecules 10:916-22. 2009
    ..These results suggest that PHA metabolism is likely to be controlled by the [acetyl-CoA]/[CoA] and [NADH]/[NAD] ratios. The physiological roles of simultaneous PHA accumulation and degradation are also discussed...
  35. ncbi A methodology for estimating human exposure to perfluorooctanoic acid (PFOA): a retrospective exposure assessment of a community (1951-2003)
    Dennis J Paustenbach
    ChemRisk, Inc, San Francisco, California 94105, USA
    J Toxicol Environ Health A 70:28-57. 2007
    ....
  36. ncbi Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant
    Maria José Lopez-Espinosa
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
    Environ Sci Technol 45:8160-6. 2011
    ..In conclusion, our study showed a later age of puberty in this population correlated with PFC concentrations...
  37. ncbi Gestational PFOA exposure of mice is associated with altered mammary gland development in dams and female offspring
    Sally S White
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA
    Toxicol Sci 96:133-44. 2007
    ..These findings suggest that in addition to gestational exposure, abnormal lactational development of dams may play a role in early growth retardation of developmentally exposed offspring...
  38. ncbi A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden
    Maria Sundström
    Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden
    Environ Int 37:178-83. 2011
    ..The temporal concentration trends of PFOS, PFHxS, and PFOA observed in human milk are parallel to those reported in the general population serum concentrations...
  39. ncbi Estimating consumer exposure to PFOS and PFOA
    David Trudel
    Institute for Chemical and Bioengineering, Wolfgang Pauli Str 10, ETH Zurich, CH 8093 Zurich, Switzerland
    Risk Anal 28:251-69. 2008
    ..The uptake estimates based on scenarios are within the range of values derived from blood serum data by applying a one-compartment pharmacokinetic model...
  40. ncbi A map of European emissions and concentrations of PFOS and PFOA
    Alberto Pistocchi
    European Commission, Joint Research Centre, Institute for Environment and Sustainability, Via Enrico Fermi, 21020 Ispra, Italy
    Environ Sci Technol 43:9237-44. 2009
    ....
  41. ncbi Perfluorinated acids and hypothyroxinemia in pregnant women
    Emily Chan
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Environ Res 111:559-64. 2011
    ..The current findings do not support a causal link between PFA exposure and maternal hypothyroxinemia in the studied population...
  42. ncbi Maternal concentrations of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) and duration of breastfeeding
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, UCLA, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Scand J Work Environ Health 36:413-21. 2010
    ..Perfluorooctanoate (PFOA) has been associated with impaired lactation in mice. We examined whether maternal perfluorooctanesulfonate (PFOS) and PFOA concentrations correlated with duration of breastfeeding among women...
  43. ncbi Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure
    Line S Haug
    Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Int 37:687-93. 2011
    ..Even though food in general is the major source of exposure for PFCs, the indoor environment may be an important contributor to human exposure. This study provides valuable knowledge for risk assessment of PFCs and control strategies...
  44. ncbi The toxicology of perfluorooctanoate
    Gerald L Kennedy
    DuPont, Newark, Delaware, USA
    Crit Rev Toxicol 34:351-84. 2004
    ..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects...
  45. ncbi Characterization of risk for general population exposure to perfluorooctanoate
    John L Butenhoff
    Medical Department, 3M Company, Building 220 2E 02, St Paul, MN 55144, USA
    Regul Toxicol Pharmacol 39:363-80. 2004
    ..These MOE values represent substantial protection of children, adults, and the elderly...
  46. ncbi Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome
    Cheryl R Stein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Am J Epidemiol 170:837-46. 2009
    ....
  47. pmc Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 115:1677-82. 2007
    ..They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in humans is uncertain...
  48. pmc Perfluorooctanoic acid effects on steroid hormone and growth factor levels mediate stimulation of peripubertal mammary gland development in C57BL/6 mice
    Yong Zhao
    Department of Physiology, Michigan State University, East Lansing, Michigan 48824, USA
    Toxicol Sci 115:214-24. 2010
    ....
  49. ncbi Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
    Erin P Hines
    U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
    Mol Cell Endocrinol 304:97-105. 2009
    ..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...
  50. ncbi Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
    Kurunthachalam Kannan
    Wadsworth Center, New York State Department of Health, and Department of Environmental Toxicology and Health, State University of New York, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, USA
    Environ Sci Technol 38:4489-95. 2004
    ..Further studies should focus on identifying sources and pathways of human exposure to perfluorochemicals...
  51. pmc The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water
    Lynda A Nolan
    Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Reprod Toxicol 27:231-8. 2009
    ..Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio have serum PFOA levels approximately 80 times those in the general U.S. population...
  52. ncbi Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
    Kouji Harada
    Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606 8501, Japan
    Environ Res 99:253-61. 2005
    ..We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS...
  53. ncbi Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults
    Chien Yu Lin
    Department of Internal Medicine, En Chu Kong Hospital, Taipei County, Taiwan, and Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
    Am J Gastroenterol 105:1354-63. 2010
    ..Perfluorinated chemicals (PFCs) have been largely used for years in a variety of products worldwide. However, the toxic effect of PFCs on exposure to the liver in the general population has not yet been determined...
  54. ncbi Exposure assessment and risk characterization for perfluorooctanoate in selected consumer articles
    Stephen T Washburn
    ENVIRON International Corporation, 6001 Shellmound Street, Suite 700, Emeryville, California 94608, USA
    Environ Sci Technol 39:3904-10. 2005
    ....
  55. pmc Effects of perfluorooctanoic acid on mouse mammary gland development and differentiation resulting from cross-foster and restricted gestational exposures
    Sally S White
    U S EPA, ORD, National Health and Environmental Effects Research Laboratory, Research Triangle Park, NC, USA
    Reprod Toxicol 27:289-98. 2009
    ..These studies confirm a window of MG sensitivity in late fetal and early neonatal life, and demonstrate developmental PFOA exposure results in early and persistent MG effects, suggesting permanent consequences...
  56. ncbi Perfluorooctanoate: Placental and lactational transport pharmacokinetics in rats
    Paul M Hinderliter
    DuPont Haskell Laboratory for Health and Environmental Sciences, 1090 Elkton Road, P O Box 50, Newark, DE 19714, USA
    Toxicology 211:139-48. 2005
    ..These pharmacokinetics allow estimation of the dose to developing and nursing rat offspring following maternal exposure...
  57. ncbi Estrogen-like properties of perfluorooctanoic acid as revealed by expressing hepatic estrogen-responsive genes in rare minnows (Gobiocypris rarus)
    Yanhong Wei
    Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People s Republic of China
    Environ Toxicol Chem 26:2440-7. 2007
    ..This preliminary study indicates that PFOA can disturb the activity of estrogen in mature male rare minnows by inducing hepatic estrogen-responsive genes, VTG and ERbeta, and barrier female reproduction...
  58. ncbi Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice
    Douglas C Wolf
    Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Pathol 36:632-9. 2008
    ..These data suggest that PPAR-alpha is required for WY- and PFOA-induced cellular alterations in WT mouse liver. Hepatic enlargement observed in KO mice may be due to an accumulation of cytoplasmic vacuoles that contain PFOA...
  59. ncbi Genotoxic risk and oxidative DNA damage in HepG2 cells exposed to perfluorooctanoic acid
    Xiaofeng Yao
    Department of Toxicology, Dalian Medical University, 465 Zhongshan Road, Dalian, 116027 Liaoning, China
    Mutat Res 587:38-44. 2005
    ..Significantly increased levels of ROS and 8-OHdG were observed in these cells. We conclude that PFOA exerts genotoxic effects on HepG2 cells, probably through oxidative DNA damage induced by intracellular ROS...
  60. ncbi Efficacy and safety of two whole IgG polyvalent antivenoms, refined by caprylic acid fractionation with or without beta-propiolactone, in the treatment of Bothrops asper bites in Colombia
    Rafael Otero
    Programa de Ofidismo Escorpionismo, Facultad de Medicina, Universidad de Antioquia, Medellin, Colombia
    Trans R Soc Trop Med Hyg 100:1173-82. 2006
    ..A further dose of antivenom at 6 h also did not guarantee resolution of coagulopathy within 12-24 h in all patients. The incidence of early adverse reactions (all mild) was similar for both antivenoms (15% and 24%; P>0.05)...
  61. ncbi A cross-sectional analysis of type II diabetes in a community with exposure to perfluorooctanoic acid (PFOA)
    Jessica MacNeil
    Department of Environmental and Occupational Health, Rollins School Public Health, Atlanta, GA, USA
    Environ Res 109:997-1003. 2009
    ..We analyzed the relationships among serum PFOA, type II diabetes, and fasting glucose in a population with high levels of serum PFOA resulting from drinking contaminated water...
  62. pmc Perfluoroalkyl chemicals and chronic kidney disease in US adults
    Anoop Shankar
    Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    Am J Epidemiol 174:893-900. 2011
    ..04, 2.88; P for trend = 0.015) for perfluorooctanoic acid and 1.82 (95% confidence interval: 1.01, 3.27; P for trend = 0.019) for perfluorooctane sulfonate. The present results suggest that elevated PFC levels are associated with CKD...
  63. ncbi Occurrence of perfluorinated substances in an adult German population in southern Bavaria
    H Fromme
    Bavarian Health and Food Safety Authority, Department of Environmental Health, Veterinaerstrasse 2, 85764 Oberschleissheim, Germany
    Int Arch Occup Environ Health 80:313-9. 2007
    ..Because of their global occurrence in different environmental media, their persistence, and their potential to bioaccumulate in organisms they are of toxicological and public concern...
  64. pmc Guest editorial: biomarkers of perfluorinated chemicals and birth weight
    David A Savitz
    Environ Health Perspect 115:A528-9. 2007
  65. pmc Perfluorooctanoic acid-induced immunomodulation in adult C57BL/6J or C57BL/6N female mice
    Jamie C DeWitt
    Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Environ Health Perspect 116:644-50. 2008
    ..Perfluorooctanoic acid (PFOA), an environmentally persistent compound of regulatory concern, has been reported to reduce antibody responses in mice at a single dose...
  66. ncbi Analysis of episodes of care in a perfluorooctanesulfonyl fluoride production facility
    Geary W Olsen
    3M Medical Company, Medical Department, St Paul, Minnesota 55144, USA
    J Occup Environ Med 46:837-46. 2004
    ..Non-a priori associations among the fluorochemical plant workers included benign colon polyps, malignant colorectal tumors, and malignant melanoma...
  67. ncbi Determining the molecular interactions of perfluorinated carboxylic acids with human sera and isolated human serum albumin using nuclear magnetic resonance spectroscopy
    Jessica C D'eon
    Department of Chemistry, University of Toronto, Toronto, Ontario, M5S 3H6 Canada
    Environ Toxicol Chem 29:1678-88. 2010
    ..Interactions between PFCAs and HSA may affect the pharmacokinetics and distribution of fatty acids and certain drugs in the human body and warrant further investigation...
  68. ncbi Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice
    Mousumi Rahman Qazi
    Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
    Int Immunopharmacol 10:1420-7. 2010
    ..Thus, in mice, PFOA- and PFOS-induced hepatomegaly is associated with significant alterations in hepatic histophysiology and immune status, as well as induction of hepatic erythropoiesis...
  69. pmc Exposure to polyfluoroalkyl chemicals and attention deficit/hyperactivity disorder in U.S. children 12-15 years of age
    Kate Hoffman
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 118:1762-7. 2010
    ..Exposures in the United States and in world populations are widespread. PFC exposures have been linked to various health impacts, and data in animals suggest that PFCs may be potential developmental neurotoxicants...
  70. ncbi Odd-numbered perfluorocarboxylates predominate over perfluorooctanoic acid in serum samples from Japan, Korea and Vietnam
    Kouji H Harada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Yoshida, Kyoto 606 8501, Japan
    Environ Int 37:1183-9. 2011
    ..The proportion of long-chain PFCAs in serum was relatively high compared to reports in Western countries. Further investigations into the sources and exposure routes are needed to predict the future trajectory of these serum PFCA levels...
  71. ncbi Comparison between free serum thyroxine levels, measured by analog and dialysis methods, in the presence of perfluorooctane sulfonate and perfluorooctanoate
    Maria José Lopez-Espinosa
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
    Reprod Toxicol 33:552-5. 2012
    ..The present findings do not indicate any observable bias from the use of the analog with respect to the dialysis method, across the range of PFOS and PFOA concentrations in this population...
  72. pmc Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources
    Edward Anthony Emmett
    University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 4284, USA
    J Occup Environ Med 48:759-70. 2006
    ....
  73. pmc Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry
    Madisa B Macon
    Curriculum in Toxicology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 25799, USA
    Toxicol Sci 122:134-45. 2011
    ..Due to the low-dose sensitivity of mammary glands to PFOA in CD-1 mice, a no observable adverse effect level for mammary developmental delays was not identified in these studies...
  74. ncbi Fractionation of equine antivenom using caprylic acid precipitation in combination with cationic ion-exchange chromatography
    Rutai Raweerith
    Department of Biotechnology, Faculty of Science, Mahidol University, Rama 6 Road, Rajthevi, Bangkok 10400, Thailand
    J Immunol Methods 282:63-72. 2003
    ..This process simultaneously and effectively removed residual pepsin, high molecular weight aggregates and CA in the final F(ab')(2) product, and should be suitable for large-scale fractionation of therapeutic equine antivenoms...
  75. ncbi Does exposure to perfluoroalkyl acids present a risk to human health?
    Mitchell B Rosen
    Integrated Systems Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 111:1-3. 2009
  76. ncbi Assessment of lipid, hepatic, and thyroid parameters with serum perfluorooctanoate (PFOA) concentrations in fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, Mail Stop 220 6W 08, St Paul, MN 55144, USA
    Int Arch Occup Environ Health 81:231-46. 2007
    ..The purpose of this assessment was to examine this association in male workers who manufactured or used PFOA at three facilities...
  77. ncbi Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study
    Linda Hanssen
    Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway
    J Environ Monit 12:1355-61. 2010
    ..Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products...
  78. ncbi Absorption, distribution, and excretion of ammonium perfluorooctanoate (APFO) after oral administration to various species
    S G Hundley
    Food and Drug Administration, Center for Drug and Evaluation and Research, Rockville, Maryland, USA
    Drug Chem Toxicol 29:137-45. 2006
    ..The slow excretors exhibited the highest 14C concentrations in the blood and liver followed by the kidneys, lungs, and skin...
  79. pmc Predictors of PFOA levels in a community surrounding a chemical plant
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 117:1083-8. 2009
    ..S. Environmental Protection Agency. It does not exist in nature but has been used widely since World War II. It is present in the serum of most Americans at about 4-5 ng/mL, although the routes of exposure remain unknown...
  80. ncbi Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 1772, USA
    Am J Epidemiol 168:66-72. 2008
    ..Maternal PFOS levels were not associated with any of the five fetal growth indicators. These findings suggest that fetal exposure to PFOA but not PFOS during organ development may affect the growth of organs and the skeleton...
  81. ncbi Use of isotopically labelled octanoic acid to assess the effect of meal size on gastric emptying
    Sarah J Jackson
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Rapid Commun Mass Spectrom 18:1003-7. 2004
    ..The deuterium method allows the direct calculation of the gastric emptying function and could be used as an alternative to gamma scintigraphy, allowing further validation of the (13)C-octanoic acid breath test...
  82. ncbi Occurrence of perfluorosulfonates and other perfluorochemicals in dust from selected homes in the city of Ottawa, Canada
    Cariton Kubwabo
    Health Canada, Healthy Environments and Consumer Safety Branch, Safe Environments Programme, Tunney s Pasture, Building No 8, Ottawa Ontario PL 0800C, CanadaK1A 0L2
    J Environ Monit 7:1074-8. 2005
    ..The data revealed a correlation between the concentrations of PFCs and the percentage of carpeting in the house; older houses tended to have less carpeting, hence lower levels of these perfluorinated compounds in their dust...
  83. ncbi Tracking the pathways of human exposure to perfluorocarboxylates
    Robin Vestergren
    Department of Applied Environmental Science ITM, Stockholm University, Svante Arrhenius väg 8C, SE 10691 Stockholm, Sweden
    Environ Sci Technol 43:5565-75. 2009
    ..5-5.5 of the daily intakes derived from exposure media, which provides further supporting evidence that dietary exposure is a major ongoing exposure pathway of PFOA to the background population...
  84. ncbi Frequent feeding delays the gastric emptying of a subsequent meal
    S J Jackson
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Fulbourn Road, Cambridge CB1 9NL, UK
    Appetite 48:199-205. 2007
    ..In conclusion, short-term increases in feeding frequency delayed the gastric emptying of a subsequent meal, but significant effects on post-meal appetite could not be demonstrated...
  85. ncbi Delayed gastric emptying in the obese: an assessment using the non-invasive (13)C-octanoic acid breath test
    S J Jackson
    MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
    Diabetes Obes Metab 6:264-70. 2004
    ..This study was designed to overcome some of the discrepancies encountered in previous studies and to test the hypothesis that obese individuals have altered gastric emptying compared to lean individuals...
  86. ncbi Development and validation of a reverse phase HPLC method for the determination of caprylic acid in formulations of therapeutic immunoglobulins and its application to antivenom production
    Maria Herrera
    Instituto Clodomiro Picado, Facultad de Microbiologia, Universidad de Costa Rica, San Jose, Costa Rica
    Biologicals 37:230-4. 2009
    ....
  87. ncbi Use of simple pharmacokinetic modeling to characterize exposure of Australians to perfluorooctanoic acid and perfluorooctane sulfonic acid
    Jack Thompson
    The University of Queensland, National Research Centre for Environmental Toxicology, 39 Kessels Road, Coopers Plains, QLD, 4108, Australia
    Environ Int 36:390-7. 2010
    ..The same results were seen for PFOS intake with significant differences by age group (p<0.001), sex (p=0.001) and date of collection (p=0.016)...
  88. ncbi Thirty years of medical surveillance in perfluooctanoic acid production workers
    Giovanni Costa
    Department of Occupational and Environmental Health, University of Milano, Italy
    J Occup Environ Med 51:364-72. 2009
    ..To report health outcomes of 30 years (1978-2007) of medical surveillance of workers engaged in a perfluooctanoic acid (PFOA) production plant...
  89. ncbi Evaluation of the immune system in rats and mice administered linear ammonium perfluorooctanoate
    Scott E Loveless
    DuPont Haskell Globel Centers for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 105:86-96. 2008
    ..In summary, no immune-related changes occurred in rats, even at doses causing systemic toxicity. In mice, immune-related changes occurred only at doses causing significant and profound systemic toxicity and stress...
  90. ncbi Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species
    Hongzu Ren
    NHEERL ORD, US EPA, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:266-77. 2009
    ..Lastly, we discuss evidence that human populations with greater CAR expression have lower body burdens of PFAAs...
  91. ncbi Roles of organic anion transporters in the renal excretion of perfluorooctanoic acid
    Hatsuki Nakagawa
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Basic Clin Pharmacol Toxicol 103:1-8. 2008
    ..Collectively, the difference between the perfluorooctanoic acid half-lives in human beings and rats is not likely to be attributable to differences in the affinities of these transporters for perfluorooctanoic acid...
  92. pmc Congenital anomalies, labor/delivery complications, maternal risk factors and their relationship with perfluorooctanoic acid (PFOA)-contaminated public drinking water
    Lynda A Nolan
    Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    Reprod Toxicol 29:147-55. 2010
    ..In this investigation, we expand the scope of our analysis to examine the associations between PFOA, congenital anomalies, labor and delivery complications and maternal risk factors...
  93. ncbi Time dependencies in perfluorooctylacids disposition in rat and monkeys: a kinetic analysis
    Yu Mei Tan
    The Hamner Institutes for Health Sciences, Research Triangle Park, NC, USA
    Toxicol Lett 177:38-47. 2008
    ..Understanding these cross-species, cross-compound, and cross-gender difference is an important step in the future development of a human model for these compounds...
  94. ncbi Experimental pKa determination for perfluorooctanoic acid (PFOA) and the potential impact of pKa concentration dependence on laboratory-measured partitioning phenomena and environmental modeling
    Darcy C Burns
    Department of Chemistry, Centre for Environmental Modelling and Chemistry, Trent University, 1600 West Bank Drive, Peterborough, Ontario, K9J 7B8 Canada
    Environ Sci Technol 42:9283-8. 2008
    ..Transport, fate, and partitioning models have often ignored the presence this species completely. The environmental dissemination of PFCAs could, in part, be explained by considering the role of the neutral species...
  95. ncbi Perfluorooctanoic acid induced developmental toxicity in the mouse is dependent on expression of peroxisome proliferator activated receptor-alpha
    Barbara D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, US Environmental Protection Agency, 2525 East Highway 54, Durham, NC 27713, USA
    Toxicol Sci 98:571-81. 2007
    ..PPARalpha was required for PFOA-induced postnatal lethality and expression of one copy of the gene was sufficient to mediate this effect...
  96. ncbi Central administration of perfluorooctanoic acid inhibits cutaneous inflammation
    B K Taylor
    Department of Pharmacology, Tulane University Health Sciences Center, New Orleans, LA 70112, USA
    Inflamm Res 54:235-42. 2005
    ..To elucidate the site of action of perfluorooctanoic acid (PFOA) in the carrageenan model of peripheral inflammation...
  97. ncbi Tissue distribution of perfluorinated chemicals in harbor seals (Phoca vitulina) from the Dutch Wadden Sea
    Kristin Inneke Van de Vijver
    Department of Biology, University of Antwerp, Groenenborgerlaan 171, 2020 Antwerpen, Belgium
    Environ Sci Technol 39:6978-84. 2005
    ..These data suggest large differences in tissue distribution and accumulation patterns of perfluorinated compounds in marine organisms...
  98. ncbi Effects of perfluorooctanoic acid exposure during pregnancy in the mouse
    Christopher Lau
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 90:510-8. 2006
    ..These data indicate maternal and developmental toxicity of PFOA in the mouse, leading to early pregnancy loss, compromised postnatal survival, delays in general growth and development, and sex-specific alterations in pubertal maturation...
  99. ncbi Pharmacokinetics of perfluorooctanoate in cynomolgus monkeys
    J L Butenhoff
    3M, St Paul, Minnesota 55144, USA
    Toxicol Sci 82:394-406. 2004
    ..Based on the result of both the oral and iv studies, the elimination half-life is approximately 14-42 days, and urine is the primary route of excretion...
  100. ncbi Longitudinal study of serum lipids and liver enzymes in workers with occupational exposure to ammonium perfluorooctanoate
    Carine J Sakr
    Yale University School of Medicine, New Haven, Connecticut, USA
    J Occup Environ Med 49:872-9. 2007
    ..To examine the relationship between serum perfluorooctanoate (PFOA), a biomarker of ammonium perfluorooctanoate exposure, and lipids and liver enzymes...
  101. ncbi Levels of 12 perfluorinated chemicals in pooled australian serum, collected 2002-2003, in relation to age, gender, and region
    Anna Karrman
    Man Technology Environment MTM Research Centre, brebro University, SE 701 82 Orebro, Sweden
    Environ Sci Technol 40:3742-8. 2006
    ..S.A. These results suggest that emissions from production in the Northern Hemisphere are of less importance for human exposure...

Research Grants20

  1. A Temporal-Spatial Analysis of Breast Cancer in Upper C*
    Veronica Vieira; Fiscal Year: 2006
    ..By learning where breast cancer "hot spots" are and if they grow, intensify, or move over time, researchers will have a better understanding of how environmental risk factors may be involved. ..
  2. Community Exposure to Perfluorooctanate
    Edward Emmett; Fiscal Year: 2006
    ..Outcome measures to be evaluated include the reduction of levels of blood C8, and whether community trust is restored through an independent participatory study. ..
  3. Focal Brain Ischemia in the TNF-alpha-Transgenic Rat
    L Pettigrew; Fiscal Year: 2007
    ....
  4. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  5. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  6. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
    ..abstract_text> ..
  7. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  8. LIPID METABOLISM IN FAT CELLS
    Wen Guo; Fiscal Year: 2010
    ..Together, these studies will provide new insights into the stress-induced regulation of lipogenesis in adipocytes, a potentially important avenue for modulating energy balance. ..
  9. Ultra-Low Dose Carcinogen Testing with the Trout Model
    David Williams; Fiscal Year: 2009
    ..abstract_text> ..
  10. IRON, ZINC AND FOLATE AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2001
    ..Although all are strongly suspected of influencing risk of preterm delivery, this study should provide evidence relevant to screening practice for infection and vitamin use during pregnancy. ..
  11. Epidemiologic Evaluation of Perfluorooctyl Compounds
    James Raymer; Fiscal Year: 2003
    ..If the exposure effect is limited to a sensitive subset of the general population, our study is more likely to detect an association compared to studies that sample on PFOA/PFOS exposure status in an occupational setting. ..
  12. MARINE AND FRESHWATER BIOMEDICAL SCIENCES CENTER
    David Williams; Fiscal Year: 2006
    ..abstract_text> ..
  13. PHYSIOLOGICALLY ACTIVE NATURAL PRODUCTS
    Douglass Taber; Fiscal Year: 2007
    ..In the course of these investigations, new molecular reactivity will be developed that will substantially shorten current routes to polycyclic natural products and drug candidates. ..
  14. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  15. Repiratory Health and Community Asbestos Exposure
    Bruce Alexander; Fiscal Year: 2007
    ..Analyses will consider cumulative exposure and short, intense periods of exposure, with specific reference to exposure in childhood. ..
  16. Epigenetic toxicity of polycyclic aromatic hydrocarbons
    Brad Upham; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. EXERCISE AND SKELETAL MUSCLE FATTY ACID METABOLISM
    LORRAINE TURCOTTE; Fiscal Year: 2002
    ..For the first time, malonyl-CoA levels will be correlated to the rate of fatty acid oxidation in skeletal muscle. ..
  18. REGULATION OF TRIACYLGLYCEROL METABOLISM IN OBESITY
    Labros Sidossis; Fiscal Year: 2001
    ..The studies employ stable and radioactive isotopes for kinetic measurements and involve detailed physiologic and kinetic mathematical modeling. ..
  19. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  20. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....