- Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
Geary W Olsen
Medical Department, 3M Company, St Paul, Minnesota 55144, USA
Environ Health Perspect 115:1298-305. 2007
..The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals...
- Epidemiologic evidence on the health effects of perfluorooctanoic acid (PFOA)
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Environ Health Perspect 118:1100-8. 2010
..OBJECTIVE AND SOURCES: We reviewed the epidemiologic literature for PFOA...
- Trends in exposure to polyfluoroalkyl chemicals in the U.S. Population: 1999-2008
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, United States
Environ Sci Technol 45:8037-45. 2011
..Nonetheless, these NHANES data suggest that sociodemographic factors may influence exposure and also provide unique information on temporal trends of exposure...
- Environmental fate and transport modeling for perfluorooctanoic acid emitted from the Washington Works Facility in West Virginia
Hyeong Moo Shin
School of Social Ecology, University of California, Irvine, CA, USA
Environ Sci Technol 45:1435-42. 2011
..87. These models may be useful for estimating past and future public well water PFOA concentrations in this region...
- The C8 health project: design, methods, and participants
Stephanie J Frisbee
Department of Community Medicine, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9105, USA
Environ Health Perspect 117:1873-82. 2009
..The settlement stemmed from the perfluorooctanoic acid (PFOA, or C8) contamination of drinking water in six water districts in two states near the DuPont Washington Works facility near Parkersburg, West Virginia...
- Retrospective exposure estimation and predicted versus observed serum perfluorooctanoic acid concentrations for participants in the C8 Health Project
Hyeong Moo Shin
School of Social Ecology, University of California, Irvine, California 95616, USA
Environ Health Perspect 119:1760-5. 2011
..People living or working in eastern Ohio and western West Virginia have been exposed to perfluorooctanoic acid (PFOA) released by DuPont Washington Works facilities...
- Toxicity and toxicokinetics of perfluorooctanoic acid in humans and animals
Department of Toxicology and Applied Pharmacology, Faculty of Pharmaceutical Sciences, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
J Toxicol Sci 28:49-57. 2003
..Elucidation of the mechanisms of transport in biological systems leads to elimination and detoxification of this chemical in the human body...
- Prenatal exposure to perfluorooctanoate and risk of overweight at 20 years of age: a prospective cohort study
Thorhallur I Halldorsson
Center for Fetal Programming, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark
Environ Health Perspect 120:668-73. 2012
..A recent study on low-dose developmental exposure to PFOA in mice reported increased weight and elevated biomarkers of adiposity in postpubertal female offspring...
- Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha
Jamie C DeWitt
East Carolina University, Greenville, North Carolina, USA
Crit Rev Toxicol 39:76-94. 2009
..This multiauthored review contains brief descriptions of current and recently published work exploring immunomodulation by PFOA and PFOS, as well as a short overview of other PPARalpha ligands of therapeutic and environmental interest...
- Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population
Jessica W Nelson
Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
Environ Health Perspect 118:197-202. 2010
..Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation...
- Cohort mortality study of workers exposed to perfluorooctanoic acid
Department of Epidemiology, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 176:909-17. 2012
..These results were limited by small numbers and restriction to mortality data, which are of limited relevance for several nonfatal outcomes of a priori interest...
- Partition of environmental chemicals between maternal and fetal blood and tissues
Larry L Needham
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
Environ Sci Technol 45:1121-6. 2011
..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
- Rate of decline in serum PFOA concentrations after granular activated carbon filtration at two public water systems in Ohio and West Virginia
Scott M Bartell
Program in Public Health, University of California, Irvine, California 92697 1250, USA
Environ Health Perspect 118:222-8. 2010
..Two highly contaminated water districts began granular activated carbon filtration in 2007...
- Ammonium perfluorooctanoate production and occupational mortality
Jessica I Lundin
Division of Environmental Health Sciences, University of Minnesota, School of Public Health, Minneapolis, MN 55455, USA
Epidemiology 20:921-8. 2009
..Perfluorooctanoate (PFOA) is a synthetic chemical widely detectable in blood of nonoccupationally exposed persons. Its human health effects are not well-characterized...
- Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010
Geary W Olsen
3M Company, Medical Department, St Paul, Minnesota, United States
Environ Sci Technol 46:6330-8. 2012
..8 years reported in individuals. This similarity supports the conclusion that the dominant PFOS-related exposures to humans in the United States were greatly mitigated during the phase-out period...
- Retrospective exposure assessment of perfluorooctanoic acid serum concentrations at a fluoropolymer manufacturing plant
Susan R Woskie
Department of Work Environment, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
Ann Occup Hyg 56:1025-37. 2012
..8 for internal data comparisons and 0.6 for external data comparisons). These annualized PFOA serum estimates will be used in a series of morbidity and mortality studies of this worker cohort...
- Perfluorooctanoic acid exposure and pregnancy outcome in a highly exposed community
David A Savitz
Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA
Epidemiology 23:386-92. 2012
..We assessed the association between perfluorooctanoic acid (PFOA) and pregnancy outcome in an area with elevated exposure to PFOA from drinking water contaminated by chemical plant releases...
- Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy
Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
Environ Health Perspect 116:1391-5. 2008
..Animal studies have shown that they may affect neuromuscular development at high concentrations...
- Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study
Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway
J Environ Monit 12:1355-61. 2010
..Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products...
- Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project
Stephanie J Frisbee
Department of Community Medicine, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, 1 Medical Center Drive, Morgantown, WV 26506 9105, USA
Arch Pediatr Adolesc Med 164:860-9. 2010
..Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are man-made compounds with widespread presence in human sera. In previous occupational and adult studies, PFOA and PFOS were positively associated with serum lipid levels...
- Phenotypic dichotomy following developmental exposure to perfluorooctanoic acid (PFOA) in female CD-1 mice: Low doses induce elevated serum leptin and insulin, and overweight in mid-life
Erin P Hines
U S Environmental Protection Agency, Research Triangle Park, NC 27711, United States
Mol Cell Endocrinol 304:97-105. 2009
..01mg PFOA/kg BW. The mode of action of these effects and its relevance to human health remain to be explored...
- Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain
Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
Toxicol Sci 108:412-8. 2009
..These proteins are important for normal brain development, and altered levels of these proteins during a critical period of the brain growth spurts could be one of the mechanisms behind earlier reported behavioral defects...
- Pre- and postnatal exposure to perfluorinated compounds (PFCs)
Department of Chemical Safety and Toxicology Biomonitoring, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D 80538 Munich, Germany
Environ Sci Technol 44:7123-9. 2010
..Although the concentrations in breast milk were low, this intake led to a body burden at the age of six months similar to (PFOS) or higher than (PFOA) that found in adults...
- Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth
Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
Environ Health Perspect 117:660-7. 2009
..Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent...
- Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
Antonia M Calafat
Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Environ Health Perspect 115:1596-602. 2007
..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably...
- Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
Arch Environ Contam Toxicol 56:338-49. 2009
..The definite toxicity and high accumulation of the tested PFCs might pose a great threat to biota and human beings due to their widespread application in various fields...
- Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
Geary W Olsen
Medical Department, 3M Company, St Paul, MN 55144, USA
Reprod Toxicol 27:212-30. 2009
..Important issues are addressed regarding the methods and data analysis that may limit inferences from this particular study...
- Perfluorooctanoate and perfluorooctanesulfonate plasma levels and risk of cancer in the general Danish population
Kirsten T Eriksen
Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark
J Natl Cancer Inst 101:605-9. 2009
..99 to 1.93). Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate in the general Danish population appear not to be associated with risk of prostate, bladder, pancreatic, or liver cancer...
- Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant
Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
Am J Epidemiol 170:1268-78. 2009
..Because these data are cross-sectional, causal inference is limited. Nonetheless, the associations between these compounds and lipids raise concerns, given their common presence in the general population...
- Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey
Epidemiology and Public Health Group, eninsula Medical School, Exeter, United Kingdom
Environ Health Perspect 118:686-92. 2010
..Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health...
- Perfluorooctanoic acid alters T lymphocyte phenotypes and cytokine expression in mice
Hee Young Son
Department of Pharmacology, Kyungpook National University Medical School, Daegu 700 422, Republic of Korea
Environ Toxicol 24:580-8. 2009
..In conclusion, our data demonstrated that PFOA has an immunomodulatory effect by altering T lymphocyte phenotypes and gene expression of proinflammatory cytokines...
- Geocoding rural addresses in a community contaminated by PFOA: a comparison of methods
VERONICA M VIEIRA
Department of Environmental Health, Boston University School of Public Health, MA 02116, USA
Environ Health 9:18. 2010
..Our study compared automated and E911 methods for recovering and geocoding valid street addresses and assessed the impact of positional errors on exposure classification...
- Placental transfer of perfluorinated compounds is selective--a Norwegian Mother and Child sub-cohort study
Kristine Bjerve Gutzkow
Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Chemical Toxicology, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
Int J Hyg Environ Health 215:216-9. 2012
..Additionally, the sulfonate group seems to impede transfer efficiency. This indicates a selective placental passage of the different PFCs and hence a specific foetal exposure...
- Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis
Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, 10 University Drive, Duluth, MN 55812 2496, USA
Toxicol Lett 129:23-32. 2002
..These data demonstrate that acute administration of PFOS or PFOA causes hepatic peroxisome proliferation in rats. However, stimulation of mt biogenesis is not a characteristic response of all peroxisome proliferators...
- Effects of perfluorinated fatty acids with different carbon chain length on fatty acid profiles of hepatic lipids in mice
Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
Biol Pharm Bull 34:856-64. 2011
- Perfluorooctanoic acid induces mast cell-mediated allergic inflammation by the release of histamine and inflammatory mediators
Thoudam S K Singh
Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea
Toxicol Lett 210:64-70. 2012
..Our findings provide evidence that PFOA, the known immunotoxic agent, induces mast cell-derived allergic inflammatory reactions by histamine release and expression of pro-inflammatory cytokines...
- Chronic dietary toxicity and carcinogenicity study with ammonium perfluorooctanoate in Sprague-Dawley rats
John L Butenhoff
3M Company, Medical Department, 3M Center 220 06 W 08, Saint Paul, MN 55144, USA
Toxicology 298:1-13. 2012
..All other tumor types were those seen spontaneously in rats of this stock and age and were not associated with feeding of APFO...
- Determinants of plasma PFOA and PFOS levels among 652 Danish men
Kirsten T Eriksen
Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
Environ Sci Technol 45:8137-43. 2011
..Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation...
- Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
J A Bjork
Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA
Toxicology 288:8-17. 2011
- Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice
Department of Environmental Toxicology, Uppsala University, Norbyvägen 18 A, S 752 36 Uppsala, Sweden
Neurotoxicology 29:160-9. 2008
..These developmental neurotoxic effects are similar to those we reported earlier for PCBs and PBDEs. This suggests that PFOS and PFOA be included in the group of POPs known to be developmental neurotoxicants...
- Maternal exposure to perfluorinated acids and fetal growth
Michele P Hamm
Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
J Expo Sci Environ Epidemiol 20:589-97. 2010
..These results suggest that maternal PFA exposure has no substantial effect on fetal weight and length of gestation at the concentrations observed in this population...
- Relationships of perfluorooctanoate and perfluorooctane sulfonate serum concentrations between mother-child pairs in a population with perfluorooctanoate exposure from drinking water
London School of Hygiene and Tropical Medicine, London, United Kingdom
Environ Health Perspect 120:752-7. 2012
..This study provides an opportunity to assess the association between PFAA concentrations in mother-child pairs in a population exposed to PFOA via drinking water...
- Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA
Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Environ Health Perspect 118:229-33. 2010
..PFOA has been associated with elevated uric acid in two studies of chemical workers. Uric acid is a risk factor for hypertension and possibly other cardiovascular outcomes...
- Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone
Department of Molecular Genetics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
Cell 132:387-96. 2008
..Identification of GOAT will facilitate the search for inhibitors that reduce appetite and diminish obesity in humans...
- Ghrelin octanoylation mediated by an orphan lipid transferase
Jesus A Gutierrez
Integrative Biology, Eli Lilly and Company, 2001 West Main Street, Greenfield, IN 46140, USA
Proc Natl Acad Sci U S A 105:6320-5. 2008
..The occurrence of ghrelin and GOAT in stomach and pancreas tissues demonstrates the relevance of GOAT in the acylation of ghrelin and further implicates acylated ghrelin in pancreatic function...
- Developmental neurotoxicity of perfluorinated chemicals modeled in vitro
Theodore A Slotkin
Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
Environ Health Perspect 116:716-22. 2008
..The widespread detection of perfluoroalkyl acids and their derivatives in wildlife and humans, and their entry into the immature brain, raise increasing concern about whether these agents might be developmental neurotoxicants...
- Maternal levels of perfluorinated chemicals and subfecundity
Department of Epidemiology, School of Public Health, University of California Los Angeles, PO Box 951772, 71 254 CHS, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
Hum Reprod 24:1200-5. 2009
..Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are ubiquitous man-made compounds that are possible hormonal disruptors. We examined whether exposure to these compounds may decrease fecundity in humans...
- Perfluorinated compounds and subfecundity in pregnant women
Kristina W Whitworth
Department of Health and Human Services, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA
Epidemiology 23:257-63. 2012
..We examined subfecundity in relation to 2 perfluorinated compounds-perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)...
- Simultaneous accumulation and degradation of polyhydroxyalkanoates: futile cycle or clever regulation?
Laboratory of Biomaterials, Swiss Federal Laboratories for Materials Testing and Research Empa, CH 9014 St Gallen, Switzerland
Biomacromolecules 10:916-22. 2009
..These results suggest that PHA metabolism is likely to be controlled by the [acetyl-CoA]/[CoA] and [NADH]/[NAD] ratios. The physiological roles of simultaneous PHA accumulation and degradation are also discussed...
- Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults
Chien Yu Lin
Department of Internal Medicine of Nephrology, En Chu Kong Hospital, Taipei County, Taiwan
Diabetes Care 32:702-7. 2009
..Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known...
- Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure
Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
Environ Health Perspect 120:655-60. 2012
..Studies in humans have reported inconsistent associations between PFOA and liver enzymes...
- Relationship of perfluorooctanoic acid exposure to pregnancy outcome based on birth records in the mid-Ohio Valley
David A Savitz
Department of Epidemiology, Brown University, Providence, Rhode Island 02912, USA david_savitz brown edu
Environ Health Perspect 120:1201-7. 2012
..Perfluorooctanoic acid (PFOA) is a potential cause of adverse pregnancy outcomes, but previous studies have been limited by low exposures and small study size...
- A methodology for estimating human exposure to perfluorooctanoic acid (PFOA): a retrospective exposure assessment of a community (1951-2003)
Dennis J Paustenbach
ChemRisk, Inc, San Francisco, California 94105, USA
J Toxicol Environ Health A 70:28-57. 2007
- Perfluorooctanoic acid exposure and cancer outcomes in a contaminated community: a geographic analysis
VERONICA M VIEIRA
Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 121:318-23. 2013
..Perfluorooctanoic acid (PFOA) has been linked to cancer in occupational mortality studies and animal toxicologic research...
- Evidence of a metabolic fatty acid-sensing system in the hypothalamus and Brockmann bodies of rainbow trout: implications in food intake regulation
Laboratorio de Fisioloxia Animal, Facultade de Bioloxia, Edificio de Ciencias Experimentais, Universidade de Vigo, E 36310 Vigo, Spain
Am J Physiol Regul Integr Comp Physiol 302:R1340-50. 2012
- Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation
Department of Analytical Chemistry, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
Environ Sci Technol 44:9550-6. 2010
..There were no significant differences in isomer pattern between the mothers, or changes during the lactation period. After a year of nursing the breast-milk concentrations of PFCs, PBDEs, and PCBs were reduced by 15-94%...
- Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements
James H Raymer
RTI International, 3040 Cornwallis Road, P O Box 12194, Research Triangle Park, NC 27709, United States
Reprod Toxicol 33:419-27. 2012
..Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms...
- A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden
Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden
Environ Int 37:178-83. 2011
..The temporal concentration trends of PFOS, PFHxS, and PFOA observed in human milk are parallel to those reported in the general population serum concentrations...
- Design, methods, and population for a study of PFOA health effects among highly exposed mid-Ohio valley community residents and workers
Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
Environ Health Perspect 121:893-9. 2013
..A cohort of community residents and workers is the basis for a series of epidemiologic studies of a Mid-Ohio Valley population with substantial perfluorooctanoic acid (PFOA) exposure due to releases from a chemical plant...
- Perfluorooctanesulfonate and perfluorooctanoic acid exposures of the Italian general population
Anna Maria Ingelido
Department of the Environment and Primary Prevention, Italian National Institute for Health, Viale Regina Elena, 299, 00161 Rome, Italy
Chemosphere 80:1125-30. 2010
..005) but not for males (p>0.1). The observed strong correlation between PFOS and PFOA concentrations suggests same or similar exposure routes...
- Male reproductive system parameters in a two-generation reproduction study of ammonium perfluorooctanoate in rats and human relevance
Raymond G York
WIL Research Laboratories, 1407 George Road, Ashland, OH 44805 8946, United States
Toxicology 271:64-72. 2010
- Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant
Maria José Lopez-Espinosa
Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
Environ Sci Technol 45:8160-6. 2011
..In conclusion, our study showed a later age of puberty in this population correlated with PFC concentrations...
- Antibacterial effect of caprylic acid and monocaprylin on major bacterial mastitis pathogens
M K M Nair
Department of Animal Science, Unit 4040, University of Connecticut, Storrs 06269, USA
J Dairy Sci 88:3488-95. 2005
..Results of this study indicate that caprylic acid and monocaprylin should be evaluated as alternatives or adjuncts to antibiotics as intra-mammary infusion to treat bovine mastitis...
- Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure
Line S Haug
Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
Environ Int 37:687-93. 2011
..Even though food in general is the major source of exposure for PFCs, the indoor environment may be an important contributor to human exposure. This study provides valuable knowledge for risk assessment of PFCs and control strategies...
- Perfluoroalkyl chemicals and chronic kidney disease in US adults
Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
Am J Epidemiol 174:893-900. 2011
..04, 2.88; P for trend = 0.015) for perfluorooctanoic acid and 1.82 (95% confidence interval: 1.01, 3.27; P for trend = 0.019) for perfluorooctane sulfonate. The present results suggest that elevated PFC levels are associated with CKD...
- Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort
Krista Yorita Christensen
Epidemiology Department, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
Environ Int 37:129-35. 2011
..We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the United Kingdom to conduct a nested case-control study examining the association between age at menarche, and exposure to PFCs during pregnancy...
- Anticonvulsant profile of caprylic acid, a main constituent of the medium-chain triglyceride (MCT) ketogenic diet, in mice
Department of Animal Physiology, Institute of Biology and Biochemistry, Maria Curie Skłodowska University, Lublin, Poland
Neuropharmacology 62:1882-9. 2012
..Thus, this acute anticonvulsant property of CA may benefit and add to the overall clinical efficacy of the MCT KD...
- High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a simil
Mousumi R Qazi
Department of Biochemistry and Biophysics, Arrhenius Laboratories for the Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
Toxicology 262:207-14. 2009
..001%, w/w). These findings reveal that in addition to suppressing adaptive immunity, high-dose, short-term exposure of mice to either PFOS or PFOA augments inflammatory responses to LPS, a potent activator of innate immunity...
- Caprylic acid and medium-chain triglycerides inhibit IL-8 gene transcription in Caco-2 cells: comparison with the potent histone deacetylase inhibitor trichostatin A
Department of Clinical Cell Biology, Graduate School of Medicine, Chiba University, Chiba, Japan
Br J Pharmacol 136:280-6. 2002
- The relationship between birth weight, gestational age and perfluorooctanoic acid (PFOA)-contaminated public drinking water
Lynda A Nolan
Center of Excellence in Environmental Toxicology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
Reprod Toxicol 27:231-8. 2009
..Residents drinking PFOA-contaminated water from the Little Hocking Water Association (LHWA) in Washington County, Ohio have serum PFOA levels approximately 80 times those in the general U.S. population...
- A reduction in growth rate of Pseudomonas putida KT2442 counteracts productivity advances in medium-chain-length polyhydroxyalkanoate production from gluconate
Laboratory for Biomaterials, Swiss Federal Laboratories for Materials Science and Technology Empa, Lerchenfeldstrasse 5, 9000 St, Gallen, Switzerland
Microb Cell Fact 10:25. 2011
- The toxicology of perfluorooctanoate
Gerald L Kennedy
DuPont, Newark, Delaware, USA
Crit Rev Toxicol 34:351-84. 2004
..Epidemiological investigations and medical surveillance of occupationally exposed workers have not found consistent associations between PFOA exposure and adverse health effects...
- A cross-sectional analysis of type II diabetes in a community with exposure to perfluorooctanoic acid (PFOA)
Department of Environmental and Occupational Health, Rollins School Public Health, Atlanta, GA, USA
Environ Res 109:997-1003. 2009
..We analyzed the relationships among serum PFOA, type II diabetes, and fasting glucose in a population with high levels of serum PFOA resulting from drinking contaminated water...
- Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome
Cheryl R Stein
Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
Am J Epidemiol 170:837-46. 2009
- Comparative hepatic effects of perfluorooctanoic acid and WY 14,643 in PPAR-alpha knockout and wild-type mice
Douglas C Wolf
Environmental Carcinogenesis Division, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
Toxicol Pathol 36:632-9. 2008
..These data suggest that PPAR-alpha is required for WY- and PFOA-induced cellular alterations in WT mouse liver. Hepatic enlargement observed in KO mice may be due to an accumulation of cytoplasmic vacuoles that contain PFOA...
- Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults
Chien Yu Lin
Department of Internal Medicine, En Chu Kong Hospital, Taipei County, Taiwan, and Institute of Occupational Medicine and Industrial Hygiene, National Taiwan University College of Public Health, Taipei, Taiwan
Am J Gastroenterol 105:1354-63. 2010
..Perfluorinated chemicals (PFCs) have been largely used for years in a variety of products worldwide. However, the toxic effect of PFCs on exposure to the liver in the general population has not yet been determined...
- Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606 8501, Japan
Environ Res 99:253-61. 2005
..We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS...
- Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population
Kim E Innes
Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, USA
Am J Epidemiol 174:440-50. 2011
- Exposure to perfluorinated compounds and human semen quality in Arctic and European populations
Department of Occupational Medicine, Danish Ramazzini Center, Aarhus University Hospital, Norrebrogade 44, Building 2C, Aarhus C 8000, Denmark
Hum Reprod 27:2532-40. 2012
..Perfluorinated compounds (PFCs) have been suspected to adversely affect human reproductive health. The aim of this study was to investigate the associations between PFC exposure and male semen quality...
- Renal elimination of perfluorocarboxylates (PFCAs)
DuPont Haskell Global Centers for Health and Environmental Sciences, Newark, Delaware 19714, United States
Chem Res Toxicol 25:35-46. 2012
- Prenatal perfluorooctanoic acid exposure in CD-1 mice: low-dose developmental effects and internal dosimetry
Madisa B Macon
Curriculum in Toxicology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina 25799, USA
Toxicol Sci 122:134-45. 2011
..Due to the low-dose sensitivity of mammary glands to PFOA in CD-1 mice, a no observable adverse effect level for mammary developmental delays was not identified in these studies...
- Comparison between free serum thyroxine levels, measured by analog and dialysis methods, in the presence of perfluorooctane sulfonate and perfluorooctanoate
Maria José Lopez-Espinosa
Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
Reprod Toxicol 33:552-5. 2012
..The present findings do not indicate any observable bias from the use of the analog with respect to the dialysis method, across the range of PFOS and PFOA concentrations in this population...
- Community exposure to perfluorooctanoate: relationships between serum concentrations and exposure sources
Edward Anthony Emmett
University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania 19104 4284, USA
J Occup Environ Med 48:759-70. 2006
- Analysis of episodes of care in a perfluorooctanesulfonyl fluoride production facility
Geary W Olsen
3M Medical Company, Medical Department, St Paul, Minnesota 55144, USA
J Occup Environ Med 46:837-46. 2004
..Non-a priori associations among the fluorochemical plant workers included benign colon polyps, malignant colorectal tumors, and malignant melanoma...
- Effects of caprylic acid and triacylglycerols of both caprylic and capric acid in rabbits experimentally infected with enteropathogenic Escherichia coli O103
Institute of Animal Science, Prague Uhrineves, Pratelstvi 815, CZ 104 00, Czech Republic
Vet Microbiol 126:372-6. 2008
..71 log(10)cfu/g to 5.55-5.83 log(10)cfu/g in treated groups. It can be concluded that both antimicrobial lipids are active against coliform bacteria, and may improve the resistance of weaned rabbits to enterocolitis...
- Application of hydrotropy to transdermal formulations: hydrotropic solubilization of polyol fatty acid monoesters in water and enhancement effect on skin permeation of 5-FU
Department of Pharmaceutics, School of Pharmaceutical Sciences, Mukogawa Women s University, Hyogo Department of Bioscience, Nagahama Institute of Bio Science and Technology, Shiga, Japan
J Pharm Pharmacol 63:1008-14. 2011
..The enhancement effect was also compared with the hydrotropic formulation and the other formulations using ethanol, propylene glycol or mixed micelles...
- Perfluorooctanoic acid induces peroxisomal fatty acid oxidation and cytokine expression in the liver of male Japanese medaka (Oryzias latipes)
Jae Ho Yang
Department of Pharmacology, School of Medicine, Catholic University of Daegu, Republic of Korea
Chemosphere 81:548-52. 2010
..In addition, the present results obtained at the high concentrations may provide important biological endpoints relevant to situations such as environmental spills...
- Measurement of gastric emptying by octanoate metabolism
Sarah J Jackson
MRC Human Nutrition Research, Elsie Widdowson Laboratory, Cambridge, UK
Curr Opin Clin Nutr Metab Care 8:538-44. 2005
- Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells
Kirsten Thorup Eriksen
Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
Mutat Res 700:39-43. 2010
..This was not related to ROS generation. Collectively, these results indicate that PFCs induce only modest effects in terms of ROS production and DNA damage in a cell line representing the human liver...
- Octanoate and decanoate induce apoptosis in 3T3-L1 adipocytes
Jeong Yeh Yang
Department of Animal and Dairy Science, University of Georgia, Athens, Georgia 30602 2771, USA
J Med Food 12:959-66. 2009
..MCFAs thus decrease adipocyte number by initiating the apoptotic process in 3T3-L1 adipocytes...
- Hydrophobic drug delivery by self-assembling triblock copolymer-derived nanospheres
Department of Chemistry and Chemical Biology and New Jersey Center for Biomaterials, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854, USA
Biomacromolecules 6:2726-31. 2005
..The nanosphere-paclitaxel complexes retain in vitro the high antiproliferative activity of paclitaxel, demonstrating that these nanospheres may be useful for delivery of the hydrophobic drugs...
- Water-Tween 40/Imwitor 308-isopropyl myristate microemulsions as delivery systems for ketoprofen: small-angle X-ray scattering study
University of Ljubljana, Faculty of Chemistry and Chemical Technology, Askerceva 5, SI 1000 Ljubljana, Slovenia
Int J Pharm 327:170-7. 2006
..Interestingly, all these changes in the inner structuration of the studied systems did not affect the trend of the drug release rates in this regime of water concentrations...
- IGIV-C, a novel intravenous immunoglobulin: evaluation of safety, efficacy, mechanisms of action, and impact on quality of life
James B Bussel
New York Presbyterian Hospital, Payson 695, 525 East 68th Street, New York, New York 10021 4885, USA
Thromb Haemost 91:771-8. 2004
..Viral safety monitoring for HIV, HCV, HBV and Parvovirus B19 showed no seroconversions on study. In conclusion, IGIV-C is as safe and efficacious as IGIV-S/D in treatment of ITP...
- Safety and tolerability of a novel chromatography-based intravenous immunoglobulin when administered at a high infusion rate in patients with immune thrombocytopenic purpura
James B Bussel
Weill Medical College of Cornell University, New York Presbyterian Hospital, New York, New York 10021 4885, USA
Am J Hematol 82:192-8. 2007
..The results suggest that IGIV-C infused at rates up to 0.14 mL/kg/min in patients with ITP is well tolerated...
- Effects of fatty acids on mitochondrial beta-oxidation enzyme gene expression in renal cell lines
Institut National de la Santé et de la Recherche Médicale U319, Universite Paris VII, 75015 Paris, France
Am J Physiol Renal Physiol 283:F328-34. 2002
- Crystallization and phase behavior of fatty acid esters of 1,3 propanediol III: 1,3 propanediol dicaprylate/1,3 propanediol distearate (CC/SS) and 1,3 propanediol dicaprylate/1,3 propanediol dipalmitate (CC/PP) binary systems
Alberta Lipid Utilization Program, Department of Agricultural Food and Nutritional Science, 4 10 Agriculture Forestry Centre, University of Alberta, Edmonton, Alberta, Canada T6G 2P5
Chem Phys Lipids 151:110-24. 2008
..3 compared to the CC/SS mixtures were associated with the chain length difference...
- Inactivation of West Nile virus, vaccinia virus and viral surrogates for relevant and emergent viral pathogens in plasma-derived products
K M Remington
Preclinical Research and Pathogen Safety, Biological Products Division, Bayer Health Care, LLC, Research Triangle Park, NC 27709, USA
Vox Sang 87:10-8. 2004
..The purpose of this study was to evaluate the efficacy of current viral inactivation methods for West Nile and vaccinia viruses and to reassess the use of model viruses to predict inactivation of similar viral pathogens...
- Pharmacokinetics and pharmacodynamics of oral heparin solid dosage form in healthy human subjects
Shaker A Mousa
Pharmaceutical Research Institute at Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY 12208, USA
J Clin Pharmacol 47:1508-20. 2007
..Furthermore, the anti-factor Xa/anti-factor IIa ratio achieved is of approximately 1:1. This is the first true pharmacokinetic study to measure the chemical compositions of heparin administered by different routes...
- Development and biopharmaceutical evaluation of quinupramine-EVA matrix containing penetration enhancer for the enhanced transdermal absorption in rats
Sang Chul Shin
College of Pharmacy, Chonnam National University, Gwangju, Korea
Pharm Dev Technol 12:429-36. 2007
..These results show that the quinupramine-EVA matrix containing a permeation enhancer could be a good transdermal delivery system for providing sustained plasma concentrations...
- AMPK activator, AICAR, inhibits palmitate-induced apoptosis in osteoblast
Ji Eun Kim
Department of Physiology, College of Medicine, Yeungnam University, Daegu, South Korea
Bone 43:394-404. 2008
..These results suggest that palmitate induces apoptosis in osteoblasts through the impaired activation of ERK, and the activation of AMPK inhibits palmitate-induced apoptosis by activating ERK...
- Lipolysis of the semi-solid self-emulsifying excipient Gelucire 44/14 by digestive lipases
Laboratoire d Enzymologie Interfaciale et de Physiologie de la Lipolyse, CNRS UPR 9025, Marseille, France
Biochim Biophys Acta 1781:367-75. 2008
..This is the first time the effects of PEG and acyl chain length on the lipolytic activity of digestive lipases on PEG esters have been investigated...