1 butanol

Summary

Top Publications

  1. ncbi Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity
    Wanlaya Naowaratwattana
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Med Food 13:1045-56. 2010
  2. pmc Phospholipase D activation is an early component of the salicylic acid signaling pathway in Arabidopsis cell suspensions
    Ondrej Krinke
    UPMC Univ Paris 06, Unité de Recherche 5, Centre National de la Recherche Scientifique, Equipe d Accueil Conventionnée 7180, Laboratoire de Physiologie Cellulaire et Moleculaire des Plantes, F 94200 Ivry sur Seine, France
    Plant Physiol 150:424-36. 2009
  3. pmc Dynamics of genomic-library enrichment and identification of solvent tolerance genes for Clostridium acetobutylicum
    Jacob R Borden
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA
    Appl Environ Microbiol 73:3061-8. 2007
  4. pmc Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and changes in the cell's transcriptional program
    Christopher A Tomas
    Department of Chemical Engineering, Molecular Biology, Northwestern University, Evanston, Illinois 60208, USA
    Appl Environ Microbiol 69:4951-65. 2003
  5. ncbi Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Neurochem 90:646-53. 2004
  6. ncbi Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes
    Andreas Vocks
    Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig
    Cell Physiol Biochem 13:165-72. 2003
  7. ncbi The effects of the phospholipase D-antagonist 1-butanol on seedling development and microtubule organisation in Arabidopsis
    John Gardiner
    School of Biological Sciences, The University of Sydney, Sydney NSW 2006, Australia
    Plant Cell Physiol 44:687-96. 2003
  8. pmc Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export
    Purnima Pathre
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    EMBO J 22:4059-69. 2003
  9. ncbi Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling
    Lisa M Ballou
    Department of Medicine, Division of Hematology, Stony Brook University, Stony Brook, NY 11794 8151, USA
    FEBS Lett 550:51-6. 2003
  10. pmc Phospholipase d activation correlates with microtubule reorganization in living plant cells
    Pankaj Dhonukshe
    Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, NL 1090 GB Amsterdam, The Netherlands
    Plant Cell 15:2666-79. 2003

Detail Information

Publications251 found, 100 shown here

  1. ncbi Phenolic-containing organic extracts of mulberry (Morus alba L.) leaves inhibit HepG2 hepatoma cells through G2/M phase arrest, induction of apoptosis, and inhibition of topoisomerase IIα activity
    Wanlaya Naowaratwattana
    Department of Biochemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand
    J Med Food 13:1045-56. 2010
    ....
  2. pmc Phospholipase D activation is an early component of the salicylic acid signaling pathway in Arabidopsis cell suspensions
    Ondrej Krinke
    UPMC Univ Paris 06, Unité de Recherche 5, Centre National de la Recherche Scientifique, Equipe d Accueil Conventionnée 7180, Laboratoire de Physiologie Cellulaire et Moleculaire des Plantes, F 94200 Ivry sur Seine, France
    Plant Physiol 150:424-36. 2009
    ..The overlap with the previously described phosphatidylinositol-4-kinase pathway is discussed...
  3. pmc Dynamics of genomic-library enrichment and identification of solvent tolerance genes for Clostridium acetobutylicum
    Jacob R Borden
    Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL 60208, USA
    Appl Environ Microbiol 73:3061-8. 2007
    ..Further characterization of the genes identified in this study will likely enhance our understanding of the complex phenotype of solvent tolerance...
  4. pmc Overexpression of groESL in Clostridium acetobutylicum results in increased solvent production and tolerance, prolonged metabolism, and changes in the cell's transcriptional program
    Christopher A Tomas
    Department of Chemical Engineering, Molecular Biology, Northwestern University, Evanston, Illinois 60208, USA
    Appl Environ Microbiol 69:4951-65. 2003
    ..Both transcriptional and Western analyses revealed elevated stress protein expression in the plasmid-carrying strain...
  5. ncbi Role of phospholipase D signaling in ethanol-induced inhibition of carbachol-stimulated DNA synthesis of 1321N1 astrocytoma cells
    Marina Guizzetti
    Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, Washington 98105, USA
    J Neurochem 90:646-53. 2004
    ..Moreover, the effect of ethanol on carbachol-induced proliferation appears to be mediated, at least in part, by its ability to interact with PLD leading to a decreased synthesis of PA...
  6. ncbi Involvement of phosphatidic acid in both degranulation and oxidative activity in fMet-Leu-Phe stimulated polymorphonuclear leukocytes
    Andreas Vocks
    Institute of Medical Physics and Biophysics, Medical Faculty, University of Leipzig
    Cell Physiol Biochem 13:165-72. 2003
    ..This study was undertaken to compare intracellular signalling pathways that lead to the ROS production as well as degranulation of azurophilic granules of human fMet-Leu-Phe/cytochalasin B stimulated neutrophils...
  7. ncbi The effects of the phospholipase D-antagonist 1-butanol on seedling development and microtubule organisation in Arabidopsis
    John Gardiner
    School of Biological Sciences, The University of Sydney, Sydney NSW 2006, Australia
    Plant Cell Physiol 44:687-96. 2003
    ..We propose that production of PA by PLD may be required for normal microtubule organisation and hence normal growth in Arabidopsis...
  8. pmc Activation of phospholipase D by the small GTPase Sar1p is required to support COPII assembly and ER export
    Purnima Pathre
    Department of Cell Biology and Physiology, University of Pittsburgh School of Medicine, 3500 Terrace Street, Pittsburgh, PA 15261, USA
    EMBO J 22:4059-69. 2003
    ..Regulated modification of membrane lipid composition is required to support the cooperative interactions that enable selective transport, as we demonstrate here for the mammalian COPII coat...
  9. ncbi Ca(2+)- and phospholipase D-dependent and -independent pathways activate mTOR signaling
    Lisa M Ballou
    Department of Medicine, Division of Hematology, Stony Brook University, Stony Brook, NY 11794 8151, USA
    FEBS Lett 550:51-6. 2003
    ..The PDGF receptor, by contrast, appears to activate mTOR by a distinct pathway that does not require Ca(2+) or PLD...
  10. pmc Phospholipase d activation correlates with microtubule reorganization in living plant cells
    Pankaj Dhonukshe
    Section of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, NL 1090 GB Amsterdam, The Netherlands
    Plant Cell 15:2666-79. 2003
    ..Using these novel insights, we propose a model for the mechanism by which PLD activation triggers microtubule reorganization in plant cells...
  11. ncbi Modulation of cyclooxygenase-2 expression by phosphatidylcholine specific phospholipase C and D in macrophages stimulated with lipopolysaccharide
    Sung Chang Lee
    Nitric Oxide Radical Toxicology Research Center and Department of Pharmacology and Toxicology, College of Medicine, Inha University, Incheon 402 751, Korea
    Mol Cells 15:320-6. 2003
    ..These results suggest that inhibitors of PC-PLC, PKC and PC-PLD, or activators of PPH could be useful in the management of LPS-induced overproduction of prostaglandins and of vascular dysfunction in septic shock...
  12. ncbi Unsaturated fatty acids phosphorylate and destabilize ABCA1 through a phospholipase D2 pathway
    Yutong Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Biol Chem 280:35896-903. 2005
    ..These data provide evidence that intracellular unsaturated acyl-CoA derivatives destabilize ABCA1 by activating a PLD2 signaling pathway...
  13. ncbi New diarylheptanoids from Alnus japonica and their antioxidative activity
    Masanori Kuroyanagi
    School of Bioresources, Hiroshima Prefectural University, Nanatsuka, Shobara, Japan
    Chem Pharm Bull (Tokyo) 53:1519-23. 2005
    ..Thus the catechol structure of the diarylheptanoids is indispensable for antioxidative activity...
  14. ncbi Differential effects of two phospholipase D inhibitors, 1-butanol and N-acylethanolamine, on in vivo cytoskeletal organization and Arabidopsis seedling growth
    Christy M Motes
    Plant Biology Division, Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Protoplasma 226:109-23. 2005
    ..We propose that these compounds mediate their differential effects on cellular organization and seedling growth, in part through the differential modulation of specific PLD isoforms...
  15. pmc The role of phospholipase D and phosphatidic acid in the mechanical activation of mTOR signaling in skeletal muscle
    T A Hornberger
    Department of Bioengineering and Whitaker Institute of Biomedical Engineering, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0412, USA
    Proc Natl Acad Sci U S A 103:4741-6. 2006
    ..Because rapamycin and PA compete for binding to the FRB domain on mTOR, these results suggest that mechanical stimuli activate mTOR signaling through an enhanced binding of PA to the FRB domain on mTOR...
  16. ncbi n-Butanol induces depolymerization of microtubules in vivo and in vitro
    Ai Hirase
    Graduate School of Life Science, University of Hyogo, Japan
    Plant Cell Physiol 47:1004-9. 2006
    ..Moreover, MTs were depolymerized in the presence of n-butanol in vitro. Therefore, n-butanol is not only an activator of phospholipase D but also an effective MT-depolymerizing agent...
  17. pmc Arabidopsis PLDzeta2 regulates vesicle trafficking and is required for auxin response
    Gang Li
    National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People s Republic of China
    Plant Cell 19:281-95. 2007
    ..These results suggest that PLDzeta2 and PA are required for the normal cycling of PIN2-containing vesicles as well as for function in auxin transport and distribution, and hence auxin responses...
  18. ncbi Solvation of dried dentin matrix by water and other polar solvents
    David H Pashley
    Dept of Oral Biology and Maxillofacial Pathology, School of Dentistry, Medical College of Georgia, Augusta 30912 1129, USA
    Am J Dent 15:97-102. 2002
    ..The null hypothesis was that there are no differences in expansion forces produced by different polar solvents...
  19. ncbi Mechanism of angiotensin II-induced phospholipase D activation in bovine adrenal glomerulosa cells
    Wendy B Bollag
    Program in Cell Signaling, Department of Medicine, Institute of Molecular Medicine and Genetics, Medical College of Georgia, 1120 15th Street, 30912 2630, Augusta, GA, USA
    Mol Cell Endocrinol 192:7-16. 2002
    ..Thus, our results suggest a role for PKC, independent of calcium influx, in mediating AngII-induced PLD activation in glomerulosa cells...
  20. ncbi ANG II stimulates phospholipase D through PKCzeta activation in VSMC: implications in adhesion, spreading, and hypertrophy
    Jean Hugues Parmentier
    Dept of Pharmacology, Crowe Bldg, The Univ of Tennessee Health Science Center, Memphis, TN 38163, USA
    Am J Physiol Heart Circ Physiol 290:H46-54. 2006
    ....
  21. pmc Roles of phosphoinositides and of Spo14p (phospholipase D)-generated phosphatidic acid during yeast sporulation
    Simon A Rudge
    Department of Cellular and Molecular Medicine, School of Medicine, and Howard Hughes Medical Institute, University of California, San Diego, La Jolla, California 92093 0668, USA
    Mol Biol Cell 15:207-18. 2004
    ....
  22. ncbi A WRKY gene from creosote bush encodes an activator of the abscisic acid signaling pathway
    Xiaolu Zou
    Department of Biological Sciences, University of Nevada Las Vegas, 4505 Maryland Parkway, Las Vegas, NV 89154, USA
    J Biol Chem 279:55770-9. 2004
    ....
  23. ncbi Activation of phospholipase D induced by hydrogen peroxide in suspension-cultured rice cells
    Takeshi Yamaguchi
    Department of Rice Research, National Agricultural Research Center, National Agricultural and Bio Oriented Research Organization, Joetsu, Niigata, 943 0193 Japan
    Plant Cell Physiol 45:1261-70. 2004
    ..1%) and lavendustin A (0.05 mM). These results indicate that H2O2-inducible PLD activation enhances signal transduction leading to phytoalexin biosynthesis in rice cells...
  24. ncbi Sustained diacylglycerol accumulation resulting from prolonged G protein-coupled receptor agonist-induced phosphoinositide breakdown in hepatocytes
    Laila Sortvik Nilssen
    Department of Pharmacology, Medical Faculty, University of Oslo, PO Box 1057 Blindern, N 0316 Oslo, Norway
    J Cell Biochem 94:389-402. 2005
    ..The results suggest that DAG accumulation that is sustained for many hours in response to VP, Ang.II, NE, and prostaglandin F2alpha in hepatocytes is mainly due to phosphoinositide breakdown...
  25. ncbi Phorbol ester-induced differentiation of L6 myogenic cells involves phospholipase D activation
    Hiba Komati
    Laboratoire de Physiopathologie des Lipides et Membranes, Institut National de la Santé et de la Recherche Médicale Unité 585, Institut National des Sciences Appliquees de Lyon, 69621 Villeurbanne, France
    FEBS Lett 577:409-14. 2004
    ..TPA-induced differentiation was inhibited by 1-butanol, confirming the involvement of PLD in this effect. These data suggest that prolonged elevation of PLD activity is required for myogenic differentiation...
  26. ncbi Trp-Lys-Tyr-Met-Val-Met stimulates phagocytosis via phospho-lipase D-dependent signaling in mouse dendritic cells
    Ha Young Lee
    Medical Research Center for Cancer Molecular Therapy, College of Medicine, Dong A University, Busan 602 714, Korea
    Exp Mol Med 36:135-44. 2004
    ..4 as well as in mouse bone marrow-derived dendritic cells, this study suggests that the activation of FPR family by WKYMVM stimulates the PLD activity resulting in phagocytic activity in DC2.4 cells...
  27. ncbi Activation of phospholipase D by osmotic cell swelling
    Sebastian F B Tomassen
    Department of Biochemistry, Erasmus University Medical Center, P O Box 1738, 3000DR Rotterdam, The Netherlands
    FEBS Lett 566:287-90. 2004
    ..The results support a model of cell volume regulation in which PLD plays an essential role in the cell swelling-induced vesicle cycling and in the activation of volume-sensitive anion channels...
  28. pmc Phospholipase D is involved in myogenic differentiation through remodeling of actin cytoskeleton
    Hiba Komati
    Laboratoire de Physiopathologie des Lipides et Membranes, Institut National de la Santé et de la Recherche Médicale Unité 585, Institut National des Sciences Appliquees de Lyon, 69621 Villeurbanne, France
    Mol Biol Cell 16:1232-44. 2005
    ..These data support the hypothesis that PLD participates in myogenesis through PA- and PIP2-dependent actin fiber formation...
  29. ncbi 1-Butanol interferes with phospholipase D1 and protein kinase Calpha association and inhibits phospholipase D1 basal activity
    Tianhui Hu
    Department of Molecular Physiology and Biophysics, Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 327:1047-51. 2005
    ..These results indicate that 1-butanol is inhibitory to PLD1 activity by reducing its association with PKCalpha, and that the concentration of 1-butanol is an important consideration in assaying basal PLD1 activity...
  30. ncbi Higher-alcohols biorefinery: improvement of catalyst for ethanol conversion
    Edwin S Olson
    Energy and Environmental Research Center, University of North Dakota, PO Box 9018, Grand Forks, ND 58202 9018, USA
    Appl Biochem Biotechnol 113:913-32. 2004
    ..The most successful catalysts are multifunctional with basic and hydrogen transfer components...
  31. ncbi Role of phospholipase D in the activation of protein kinase D by lysophosphatidic acid
    Yoonseok Kam
    Department of Molecular Physiology and Biophysics, Howard Hughes Medical Institute, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    Biochem Biophys Res Commun 315:139-43. 2004
    ....
  32. ncbi An essential role for phospholipase D in the activation of protein kinase C and degranulation in mast cells
    Ze Peng
    Laboratory of Molecular Immunology, National, Heart, Lung, and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
    J Immunol 174:5201-8. 2005
    ..These results suggested that the production of phosphatidic acid by PLD facilitates activation of PKC and, in turn, degranulation, although additional PLD-dependent processes appear to be critical for Ag-mediated degranulation...
  33. ncbi Role of phospholipase D1 in the regulation of mTOR activity by lysophosphatidic acid
    Yoonseok Kam
    Howard Hughes Medical Institute and the Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    FASEB J 18:311-9. 2004
    ..These results support the hypothesis that LPA activates protein translation through the action of PLD1-generated PA on mTOR and the PI3K/Akt pathway whereas PDGF acts through P13K/Akt independent of PLD1...
  34. ncbi Cut-off phenomenon in the protective effect of alcohols against lysophosphatidylcholine-induced calcium overload
    Louis Jean Bordeleau
    Quebec Heart Institute, Laval Hospital Research Center, 2725 Chemin Ste Foy, Ste Foy, QC, Canada, G1V 4G5
    Pflugers Arch 450:292-7. 2005
    ....
  35. ncbi C2C12 skeletal muscle cells exposure to phosphatidylcholine triggers IGF-1 like-responses
    Cyril Rauch
    Royal Veterinary College, Muscle Unit and Molecular Biology VBS, Royal College Street, NW1 OTU London
    Cell Physiol Biochem 15:211-24. 2005
    ..Moreover, we also show that long-term change in phospholipid composition disrupts both the IGF-1 signalling pathway and GLUT1 partitioning within the cells...
  36. ncbi Effect of alcohols on protein hydration: crystallographic analysis of hen egg-white lysozyme in the presence of alcohols
    Ashlesha Deshpande
    Centre for DNA Fingerprinting and Diagnostics, ECIL Road, Nacharam, Hyderabad 500076, India
    Acta Crystallogr D Biol Crystallogr 61:1005-8. 2005
    ..It is believed that the disorder induced in the water molecules is a direct consequence of alcohol binding...
  37. ncbi Involvement of phospholipase D1 in melanogenesis of mouse B16 melanoma cells
    Kenji Ohguchi
    Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Biol Chem 279:3408-12. 2004
    ..These results indicated that PLD1 negatively regulated the melanogenic signaling by modulating the expression of tyrosinase in mouse B16 melanoma cells...
  38. ncbi Enhancement of ultrasonically initiated emulsion polymerization rate using aliphatic alcohols as hydroxyl radical scavengers
    Min Nie
    State Key Laboratory of Polymer Materials Engineering, Polymer Research Institute, Sichuan University, Chengdu 610065, China
    Ultrason Sonochem 15:222-6. 2008
    ..Obviously, it is an effective way to enhance ultrasonically initiated emulsion polymerization rate of styrene by adding volatile hydroxyl radical scavenger...
  39. ncbi Activation of polyphenol oxidase in extracts of bran from several wheat (Triticum aestivum) cultivars using organic solvents, detergents, and chaotropes
    Moses Okot-Kotber
    Department of Grain Science and Industry, Kansas State University, Manhattan, Kansas 66506, USA
    J Agric Food Chem 50:2410-7. 2002
    ..It is hypothesized that in wheat PPO exists in an inactive form which may be activated by the presence of activators, hitherto unknown, similar in effect to that elicited by the chemical denaturants in this study...
  40. ncbi The role of diacylglyceride generation by phospholipase D and phosphatidic acid phosphatase in the activation of 5-lipoxygenase in polymorphonuclear leukocytes
    Dana Albert
    Institute of Pharmaceutical Chemistry, University of Frankfurt, Frankfurt, Germany
    J Leukoc Biol 83:1019-27. 2008
    ..Together, our data suggest that in agonist-stimulated PMNL, the endogenous formation of DAGs via the PLD/PA-P pathway determines 5-LO activation...
  41. ncbi Phospholipase D stimulation is required for sphingosine-1-phosphate activation of actin stress fibre assembly in human airway epithelial cells
    Anna M Porcelli
    Dipartimento di Biologia Evoluzionistica Sperimentale, Universita di Bologna, Via Irnerio 42, 40126 Bologna, Italy
    Cell Signal 14:75-81. 2002
    ..Addition of PA to cells caused a massive stress fibre assembly. In conclusion, PLD is one of the signalling components linking SPP-receptor activation to assembly of actin stress fibres...
  42. ncbi Antidepressant effect of Yueju-Wan ethanol extract and its fractions in mice models of despair
    X H Wei
    Shanghai R and D Center for Standardization of Traditional Chinese Medicine, Shanghai 201203, China
    J Ethnopharmacol 117:339-44. 2008
    ....
  43. ncbi ETOH inhibits embryonic neural stem/precursor cell proliferation via PLD signaling
    Yuko Fujita
    Department of Pharmacology, National Research Institute for Child Health and Development, 2 10 1 Okura, Setagaya Ku, Tokyo 157 8535, Japan
    Biochem Biophys Res Commun 370:169-73. 2008
    ..These results indicate that exposure to ETOH impairs NSC proliferation by altering the PLD signaling pathway...
  44. ncbi Phosphatidylcholine-specific phospholipase C regulates activation of RAW264.7 macrophage-like cells by lipopeptide JBT3002
    F Zhang
    Department of Cancer Biology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA
    J Leukoc Biol 69:1060-6. 2001
    ..RAW264.7 cells treated with DAG analogue 1-oleoyl-2-acetyl-sn-glycerol, in the presence of interferon-gamma, produced TNF-alpha. These results suggested that activation of RAW264.7 cells by JBT3002 requires PC-PLC activity...
  45. ncbi Vasopressin-stimulated Ca2+ spiking in vascular smooth muscle cells involves phospholipase D
    Y Li
    Department of Physiology, Loyola University, Chicago, Illinois 60626, USA
    Am J Physiol Heart Circ Physiol 280:H2658-64. 2001
    ..These results suggest that AVP-stimulated Ca2+ spiking depends on activation of PLD rather than PLA2 and that PKC activation may be downstream of PLD in the signaling cascade...
  46. ncbi Functional interactions of lanthanum and phospholipase D with the abscisic acid signaling effectors VP1 and ABI1-1 in rice protoplasts
    S S Gampala
    Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    J Biol Chem 276:9855-60. 2001
    ..These results demonstrate that ABA, VP1, lanthanum, PLD, and ABI1 are all involved in ABA-regulated gene expression and are consistent with an integrated model whereby La(3+) acts upstream of PLD...
  47. pmc Role for phospholipase D in receptor-mediated endocytosis
    Y Shen
    Department of Biological Sciences, Hunter College of the City University of New York, New York, New York 10021, USA
    Mol Cell Biol 21:595-602. 2001
    ..EGF-induced activation of mitogen-activated protein kinase, which is dependent upon receptor endocytosis, is also dependent upon PLD. These data suggest a role for PLD in signaling that facilitates receptor endocytosis...
  48. ncbi Increased phospholipase D2 activity during hypoxia-induced death of PC12 cells: its possible anti-apoptotic role
    H Yamakawa
    Department of Neurosurgery, Gifu University School of Medicine, Japan
    Neuroreport 11:3647-50. 2000
    ..Moreover, the number of apoptotic cells significantly reduced in PC12 cells over-expressing PLD2. These results raise the possibility that PLD2 activation may play an anti-apoptotic role in hypoxia-induced cell death...
  49. ncbi Preferential solvation of Brooker's merocyanine in binary solvent mixtures composed of formamides and hydroxylic solvents
    Tharly Bevilaqua
    Centro Tecnológico, GRUCENSO, Pró Reitoria Acadêmica, Universidade do Sul de Santa Catarina, CP 370, 88704 900 Tubarão, SC, Brazil
    Spectrochim Acta A Mol Biomol Spectrosc 60:951-8. 2004
    ..The results suggest that both hydrogen bonding and solvophobic interactions contribute to the formation of the solvent complexes responsible for the observed synergistic effects in the PS of the dye...
  50. ncbi Nonaqueous capillary electrophoresis with alcoholic background electrolytes: separation efficiency under high electrical field strengths
    Sami Palonen
    Laboratory of Analytical Chemistry, Department of Chemistry, University of Helsinki, Finland
    Electrophoresis 23:393-9. 2002
    ..Capillary preconditioning had a varied effect on the separations in the different BGEs as the BGE and the conditioning process affected the electroosmotic flow (EOF) velocity and direction...
  51. ncbi [Comparison of the anti-fertility effects of four extracts from the roots of Rhynchosia volubilis Lour]
    Jian gang Wang
    Family Planning Research Institute, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China
    Zhonghua Nan Ke Xue 13:871-5. 2007
    ..To compare the anti-fertility effects of the four extracts from the roots of Rhynchosia volubilis Lour on male mice, that is, ethanolic extract, ethyl acetate extract, n-butanol extract and aqueous extract...
  52. ncbi Phospholipase D regulates calcium oscillation frequency and nuclear factor-kappaB activity in histamine- stimulated human endothelial cells
    Qinghua Hu
    Department of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, Maryland 21224 2780, USA
    Biochem Biophys Res Commun 292:325-32. 2002
    ..This study shows that activation of PLD by histamine regulates [Ca(2+)](i) oscillation frequency and NF-kappaB activity in HAEC...
  53. ncbi Inverse gas chromatography study on the effect of humidity on the mass transport of alcohols in an ethylene-vinyl alcohol copolymer near the glass transition temperature
    David Cava
    Instituto de Agroquimica y Tecnologia de Alimentos, CSIC Packaging Lab Apdo Correos 73, 46100 Burjassot, Valencia, Spain
    J Chromatogr A 1175:267-74. 2007
    ..Finally, a sharp increment of the D(p) of the three alcohols was observed between 35 and 47% RH and attributed to the plasticization of the copolymer...
  54. ncbi Requirement of phospholipase D for ilimaquinone-induced Golgi membrane fragmentation
    Hirofumi Sonoda
    Division of Biochemistry, Department of Molecular and Cellular Biology, Kobe University Graduate School of Medicine, Kobe, Japan
    J Biol Chem 282:34085-92. 2007
    ....
  55. ncbi PLD regulates myoblast differentiation through the mTOR-IGF2 pathway
    Mee Sup Yoon
    Department of Cell and Developmental Biology, University of Illinois at Urbana Champaign, 601 S Goodwin Avenue B107, Urbana, IL 61801, USA
    J Cell Sci 121:282-9. 2008
    ..Furthermore, exogenous IGF2 fully rescues the differentiation defect resulting from PLD1 knockdown. Hence, PLD1 is critically involved in skeletal myogenesis by regulating the mTOR-IGF2 pathway...
  56. ncbi Degradation of hexane and other recalcitrant hydrocarbons by a novel isolate, Rhodococcus sp. EH831
    Eun Hee Lee
    Department of Environmental Science and Engineering, Ewha Womans University, Seoul, 120 750, Republic of Korea
    Environ Sci Pollut Res Int 17:64-77. 2010
    ..In addition, the degradation characteristics of a variety of recalcitrant hydrocarbons were qualitatively and quantitatively investigated using the isolate...
  57. ncbi [Determination of 4-(methylnirosamino) -4-(3-pyridyl)-1-butanol (NNA) in urine of pregnant women by means of LC/MS/MS]
    Ewa Florek
    Laboratorium Badań Srodowiskowych, Katedra i Zakład Toksykologii, Akademii Medycznej w Poznaniu
    Przegl Lek 63:926-31. 2006
    ..Only a slight tendency for the increase in the concentration of NNAL as well as the increase in the cotinine level could be caused by the difference in pharmacokinetic parameters of marked metabolites at the moment of smoking cessation...
  58. ncbi Volatile metabolite production of spoilage micro-organisms on a mixed-lettuce agar during storage at 7 degrees C in air and low oxygen atmosphere
    P Ragaert
    Department of Food Safety and Food Quality, Laboratory of Food Microbiology and Food Preservation, Ghent University, Coupure Links 653, B 9000 Ghent, Belgium
    Int J Food Microbiol 112:162-70. 2006
    ....
  59. ncbi Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes
    T J Smith
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, NJ 08855, USA
    Carcinogenesis 18:1577-84. 1997
    ..The patas monkey microsomes appear to more closely resemble human microsomes than mouse or rat enzymes and may better reflect the activation of NNK in humans...
  60. pmc Identification of the human mitochondrial linoleoyl-coenzyme A monolysocardiolipin acyltransferase (MLCL AT-1)
    William A Taylor
    Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba R3E 0T6, Canada
    J Biol Chem 284:30360-71. 2009
    ..The results identify MLCL AT-1 as a human mitochondrial monolysocardiolipin acyltransferase involved in the remodeling of cardiolipin...
  61. ncbi Surrogate alcohols and their metabolites modify histone H3 acetylation: involvement of histone acetyl transferase and histone deacetylase
    Mahua Choudhury
    Department of Medical Pharmacology and Physiology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
    Alcohol Clin Exp Res 32:829-39. 2008
    ..Hence, we investigated the effect of these alcohols on histone H3 acetylation, cell toxicity and HAT and HDAC activity...
  62. ncbi Variation of some fermentative sulfur compounds in Italian "millesime" classic sparkling wines during aging and storage on lees
    Bruno Fedrizzi
    Chemical Sciences Department, University of Padova, Via Marzolo 1, 35131 Padova, Italy
    J Agric Food Chem 58:9716-22. 2010
    ..No clear influence of lees contact duration was found for the majority of the sulfur compounds considered...
  63. ncbi [Saccharomyces cerevisiae B5 efficiently and stereoselectively reduces 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol in the presence of 5% ethanol]
    Zhi min Ou
    Institute of Biochemical Engineering, College of Material Science and Chemical Engineering, Zhejiang University, Hangzhou 310027, China
    Sheng Wu Gong Cheng Xue Bao 19:206-11. 2003
    ..The yeast can be reused up to 15 times. This research paves the way for economical preparation of chiral 2'-chloroacetophenone to R-2'-chloro-1-phenylethanol...
  64. ncbi Transstadial and horizontal transfer of bacteria within a colony of Anopheles gambiae (Diptera: Culicidae) and oviposition response to bacteria-containing water
    J M Lindh
    Department of Genetics, Microbiology and Toxicology, Stockholm University, Stockholm S 10691, Sweden
    Acta Trop 107:242-50. 2008
    ..Further research is needed to determine if the bacteria are also transferred in the same way in nature...
  65. ncbi Subcellular distribution and characterization of rat pancreatic phospholipase D isoforms
    J Laine
    Service de Gastroenterologie, Departement de Medecine, Faculte de Medecine, Universite de Sherbrooke, Quebec, Canada
    Pancreas 20:323-36. 2000
    ..This study presents for the first time biochemical characteristics of the pancreatic PLD activities and shows the presence of oleate-dependent PLD1 and PLD2 activities, as well as PLD1 and PLD2 proteins in this gland...
  66. ncbi Enantiomeric resolution of biomarkers in space analysis: Chemical derivatization and signal processing for gas chromatography-mass spectrometry analysis of chiral amino acids
    M C Pietrogrande
    Department of Chemistry, University of Ferrara, Via L Borsari, 46, I 44100 Ferrara, Italy
    J Chromatogr A 1217:1126-33. 2010
    ....
  67. ncbi Phosphatidic acid regulates signal output by G protein coupled receptors through direct interaction with phospholipase C-beta(1)
    Irene Litosch
    Department of Molecular and Cellular Pharmacology, Miller School of Medicine, University of Miami, Miami, Florida 33101, USA
    Cell Signal 21:1379-84. 2009
    ..Galpha(q) and PA may co-ordinate to regulate signaling. Regulation by PA may constitute part of a mechanism that routes receptor signaling to specific PLC isoforms...
  68. ncbi Extraction of cyanobacterial endotoxin
    John Papageorgiou
    CRC for Water Quality and Treatment, Australian Water Quality Centre, Private Mail Bag 3, Salisbury, South Australia, 5108, Australia
    Environ Toxicol 19:82-7. 2004
    ..Nevertheless, the ability of the novel HBW and HDW methods to utilize easily handled organic solvents that are less hazardous than phenol render them attractive alternatives to the standard HPW method...
  69. ncbi Identification of tobacco-derived compounds in human pancreatic juice
    Bogdan Prokopczyk
    American Health Foundation, Division of Cancer Etiology and Prevention, Valhalla, New York 10595, USA
    Chem Res Toxicol 15:677-85. 2002
    ..This research presents preliminary data that supports the hypothesis that pancreatic tissue is exposed to TSNA and that they may be important contributors to pancreatic carcinogenesis in humans...
  70. ncbi Mechanism of peroxidase-mediated oxidation of carcinogenic o-anisidine and its binding to DNA
    Marie Stiborova
    Department of Biochemistry, Faculty of Natural Sciences, Charles University, Albertov 2030, 128 40 Prague 2, Czech Republic
    Mutat Res 500:49-66. 2002
    ..The limitation of the 32P-postlabeling technique to analyze DNA adducts derived from o-anisidine as a means to estimate its genotoxicity is discussed...
  71. ncbi Effect of delivered dosage of cigarette smoke toxins on the levels of urinary biomarkers of exposure
    Assieh A Melikian
    Department of Environmental Medicine, New York University School of Medicine, Tuxedo, NY 10987, USA
    Cancer Epidemiol Biomarkers Prev 16:1408-15. 2007
    ..Thus, the intensity of the exposures significantly affects the levels of urinary biomarkers of exposure and should be taken into account in the evaluation of human exposure to cigarette smoke toxins...
  72. pmc Analysis of pyridyloxobutyl and pyridylhydroxybutyl DNA adducts in extrahepatic tissues of F344 rats treated chronically with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Siyi Zhang
    Department of Medicinal Chemistry and Masonic Cancer Center, University of Minnesota, MMC 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 22:926-36. 2009
    ....
  73. ncbi Atmospheric chemistry of HFE-7000 (CF(3)CF (2)CF (2)OCH (3)) and 2,2,3,3,4,4,4-heptafluoro-1-butanol (CF (3)CF (2)CF (2)CH (2)OH): kinetic rate coefficients and temperature dependence of reactions with chlorine atoms
    Yolanda Díaz-de-Mera
    Facultad Químicas, Departamento Quimica Fisica, Universidad de Castilla La Mancha, Avda Camilo Jose Cela 10, E 13071, Ciudad Real, Spain
    Environ Sci Pollut Res Int 15:584-91. 2008
    ..In the present work, we report the results obtained in the study of the reactions of Cl radicals with HFE-7000 (CF(3)CF(2)CF(2)OCH(3)) (1) and its isomer CF(3)CF(2)CF(2)CH(2)OH (2)...
  74. ncbi Assessment of five bioaccessibility assays for predicting the efficacy of petroleum hydrocarbon biodegradation in aged contaminated soils
    Catherine E Dandie
    Centre for Environmental Risk Assessment and Remediation, University of South Australia, Mawson Lakes Campus, Adelaide, South Australia 5095, Australia
    Chemosphere 81:1061-8. 2010
    ..Further evaluation and validation is required using soils from a range of hydrocarbon contamination sources in order to develop robust assays for predicting bioremediation endpoints in the field...
  75. ncbi An endophytic Phomopsis sp. possessing bioactivity and fuel potential with its volatile organic compounds
    Sanjay K Singh
    Department of Plant Sciences, Montana State University, Bozeman, MT 59717, USA
    Microb Ecol 61:729-39. 2011
    ..A discussion is presented on the possible involvement of VOC production by the fungus and its role in the biology/ecology of the fungus/plant/environmental relationship...
  76. ncbi The use of selective pharmacological inhibitors to delineate signal transduction pathways activated during complement receptor-mediated degranulation in chicken heterophils
    Michael H Kogut
    USDA ARS, Southern Plains Agricultural Research Center, 2881 F and B Road, College Station, TX 77845, USA
    Int Immunopharmacol 3:693-706. 2003
    ..Engaging CRs on chicken heterophils activates a proximal tyrosine kinase (src and Syk kinases)-->PLC (PLD)-->PI3-K-->JNK signal transduction pathway that induces degranulation...
  77. ncbi Production of volatile compounds by Rhizopus oligosporus during soybean and barley tempeh fermentation
    Xin Mei Feng
    Department of Microbiology, Swedish University of Agricultural Sciences SLU, Box 7025, SE 750 07 Uppsala, Sweden
    Int J Food Microbiol 113:133-41. 2007
    ..The mushroom odour compounds, 3-octanone and 1-octen-3-ol, were only detected from soybean and soybean tempeh...
  78. ncbi Effect of water activity on the production of volatile organic compounds by Muscodor albus and their effect on three pathogens in stored potato
    Ronan Corcuff
    Horticultural Research Centre, Pavillon de l Envirotron, Universite Laval, Quebec, Canada
    Fungal Biol 115:220-7. 2011
    ..The results show that Aw of grain culture affects the production of VOC by M. albus; and that the VOC inhibit the growth of the tested pathogens and the diseases caused by them in potato tubers...
  79. ncbi Separation of betalains from berries of Phytolacca americana by ion-pair high-speed counter-current chromatography
    Gerold Jerz
    Institute of Food Chemistry, Technische Universitat Braunschweig, Schleinitz Strasse 20, 38106 Braunschweig, Germany
    J Chromatogr A 1190:63-73. 2008
    ..americana...
  80. ncbi Defining maximum levels of higher alcohols in alcoholic beverages and surrogate alcohol products
    Dirk W Lachenmeier
    Chemisches und Veterinaruntersuchungsamt CVUA Karlsruhe, Weissenburger Strasse 3, D 76187 Karlsruhe, Germany
    Regul Toxicol Pharmacol 50:313-21. 2008
    ....
  81. ncbi Thermodynamic analysis of alcohol effect on thermal stability of proteins
    Osato Miyawaki
    Department of Food Science, Ishikawa Prefectural University, 1 308 Suematsu, Nonoichi, Ishikawa 921 8836, Japan
    J Biosci Bioeng 111:198-203. 2011
    ..The number of change in bound-alcohol molecules upon protein unfolding was also obtained...
  82. ncbi Genetic diversity of volatile components in Xinjiang Wild Apple (Malus sieversii)
    Xuesen Chen
    Biological Laboratory of Pomology, Shandong Agricultural University, Tai an 271018, China
    J Genet Genomics 34:171-9. 2007
    ..Thus, the potential of M. sieversii in "utilization conservation" is enormous as a rare germplasm on genetic improvement of M. pumila cultivars...
  83. ncbi Volatiles from Fusarium verticillioides (Sacc.) nirenb. and their attractiveness to nitidulid beetles
    R J Bartelt
    Bioactive Agents Research Unit, National Center for Agricultural Utilization Research, Agricultural Research Service, U S Department of Agriculture, Peoria, Illinois 61604, USA
    J Agric Food Chem 47:2447-54. 1999
    ..verticillioides produced ethyl acetate and other esters at unusually high levels. The fungus produced attractive volatiles following ear inoculation of milk-stage field corn as well as on sterile, mature kernels in the laboratory...
  84. ncbi Airborne concentrations of volatile organic compounds, formaldehyde and ammonia in Finnish office buildings with suspected indoor air problems
    Heidi J Salonen
    Finnish Institute of Occupational Health, Helsinki, Finland
    J Occup Environ Hyg 6:200-9. 2009
    ..The levels should not be used for the evaluation of health risks. The guideline values are applicable in a subarctic climate for modern, urban office buildings...
  85. ncbi Use of precision-cut tissue slices in organ culture to study metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by hamster lung, liver and kidney
    E Richter
    Walther Straub Institute of Pharmacology and Toxicology, Ludwig Maximilians University of Munich, Nussbaumstr 26, D 80336, Munich, Germany
    Toxicology 144:83-91. 2000
    ..Little or no metabolism of NNAL back to NNK was evident in any tissue...
  86. ncbi Evaluation of carcinogen exposure in people who used "reduced exposure" tobacco products
    Dorothy K Hatsukami
    University of Minnesota Transdisciplinary Tobacco Use Research Center and Cancer Center, Minneapolis 55414, USA
    J Natl Cancer Inst 96:844-52. 2004
    ..Although tobacco products with reportedly reduced carcinogen content are being marketed, carcinogen uptake in people who use these products has not been assessed systematically...
  87. pmc Quantitation of pyridylhydroxybutyl-DNA adducts in liver and lung of F-344 rats treated with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and enantiomers of its metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol
    Pramod Upadhyaya
    Masonic Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:1468-76. 2008
    ....
  88. ncbi Simultaneous determination of ingredients in a cold medicine by cyclodextrin-modified microemulsion electrokinetic chromatography
    Hitoshi Okamoto
    Analytical Laboratory, Taisho Pharmaceutical Co Ltd, Saitama 331 9530, Japan
    J Pharm Biomed Anal 37:517-28. 2005
    ..6 to 4.2 microg ml(-1). Good agreement was obtained between the established method and the traditional HPLC method. These results suggest that CD-MEEKC can be used for the determination of multiple ingredients in cold medicine...
  89. ncbi Comparison between micellar liquid chromatography and capillary zone electrophoresis for the determination of hydrophobic basic drugs in pharmaceutical preparations
    S Torres-Cartas
    Departmento de Quimica Analita, Facultad de Farmacia, Universidad de Valencia, Valencia, Spain
    Biomed Chromatogr 21:21-8. 2007
    ....
  90. ncbi Metabolites of a tobacco-specific lung carcinogen in nonsmoking women exposed to environmental tobacco smoke
    K E Anderson
    Division of Epidemiology, University of Minnesota, Minneapolis 55454, USA
    J Natl Cancer Inst 93:378-81. 2001
    ..We measured metabolites of a tobacco-specific lung carcinogen in urine from healthy, nonsmoking women exposed to ETS...
  91. ncbi Antioxidant and antiproliferative activities of extracts from a variety of edible seaweeds
    Yvonne V Yuan
    School of Nutrition, Faculty of Community Services, Ryerson University, 350 Victoria St, Toronto, Ont, Canada M5B 2K3
    Food Chem Toxicol 44:1144-50. 2006
    ..05), suggesting a causal link related to extract content of kelp phlorotannins and dulse polyphenols including mycosporine-like amino acids and phenolic acids...
  92. ncbi Genotype-phenotype correlation between the polymorphic UGT2B17 gene deletion and NNAL glucuronidation activities in human liver microsomes
    Philip Lazarus
    Department of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Pharmacogenet Genomics 15:769-78. 2005
    ..05) or UGT2B7 (*2/*2) (P<0.02) genotypes. These data suggest that the UGT2B17 deletion polymorphism is associated with a reduced rate of NNAL detoxification in vivo and may increase individual susceptibility to tobacco-related cancers...
  93. pmc Phospholipase D-mediated activation of IQGAP1 through Rac1 regulates hyperoxia-induced p47phox translocation and reactive oxygen species generation in lung endothelial cells
    Peter V Usatyuk
    Department of Medicine, The University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:15339-52. 2009
    ..These results demonstrate a role of PLD in hyperoxia-mediated IQGAP1 activation through Rac1 in tyrosine phosphorylation of Src and cortactin, as well as in p47(phox) translocation and ROS formation in human lung endothelial cells...
  94. ncbi Quantitation of metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone after cessation of smokeless tobacco use
    Stephen S Hecht
    University of Minnesota Cancer Center, Minneapolis, Minnesota 55455, USA
    Cancer Res 62:129-34. 2002
    ..These data may have considerable implications for understanding mechanisms of tumor induction by NNK...
  95. ncbi Effects of cruciferous vegetable consumption on urinary metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in singapore chinese
    Stephen S Hecht
    University of Minnesota Cancer Center, Mayo Mail Code 806, 420 Delaware St SE, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 13:997-1004. 2004
    ..The results of this study demonstrate the complexities in assessing effects of cruciferous vegetables on carcinogen metabolism...
  96. pmc Exposure to nicotine and a tobacco-specific carcinogen increase with duration of use of smokeless tobacco
    S S Hecht
    Cancer Center, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Tob Control 17:128-31. 2008
    ..Smokeless tobacco is an efficient delivery vehicle for nicotine and can contain significant amounts of carcinogens. However, few studies have examined factors that might moderate levels of nicotine or carcinogen exposure...
  97. ncbi Mass spectrometric quantitation of nicotine, cotinine, and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human toenails
    Irina Stepanov
    The Cancer Center, University of Minnesota, Mayo Mail Code 806, 420 Delaware Street Southeast, Minneapolis, MN 55455, USA
    Cancer Epidemiol Biomarkers Prev 15:2378-83. 2006
    ..These sensitive and quantitative methods should be useful in epidemiologic studies of the role of chronic tobacco smoke exposure, including environmental tobacco smoke exposure, in human cancer...
  98. ncbi Air formaldehyde and solvent concentrations during surface coating with acid-curing lacquers and paints in the woodworking and furniture industry
    Syvert Thorud
    National Institute of Occupational Health, Oslo, Norway
    J Environ Monit 7:586-91. 2005
    ..02-0.18). Non-painting work tasks also displayed moderate concentrations of formaldehyde (geometric means 0.11-0.17 ppm) and organic solvents (additive effect, geometric mean 0.04-0.07)...
  99. ncbi Isolation, structure, and characterization of the putative soluble amyloses from potato, wheat, and rice starches
    Rupendra Mukerjea
    Laboratory of Carbohydrate Chemistry and Enzymology, Department of Biochemistry, Biophysics, and Molecular Biology, 4252 Molecular Biology Bldg, Iowa State University, Ames, IA 50011, USA
    Carbohydr Res 345:449-51. 2010
    ..The three soluble amyloses have structures and properties intermediate between the nearly water insoluble (<or= 1mg/mL), linear amylose, and the highly water-soluble, 4-5% branched, amylopectin...
  100. ncbi Solid-phase extraction combined with headspace single-drop microextraction of chlorophenols as their methyl ethers and analysis by high-performance liquid chromatography-diode array detection
    Nisha Sharma
    Department of Chemistry, Rani Durgavati University, Pachpedi, Jabalpur 482001, Madhya Pradesh, India
    Talanta 83:994-9. 2011
    ..04-0.08 μg L(-1). Spiked real samples have been analyzed with adequate accuracy, and application of the method has been demonstrated for the analysis of chlorophenols formed upon bamboo pulp bleaching...
  101. ncbi Formation of formaldehyde adducts in the reactions of DNA and deoxyribonucleosides with alpha-acetates of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL), and N-nitrosodimethylamine (NDMA)
    Guang Cheng
    University of Minnesota Cancer Center, MMC 806, 420 Delaware Street Southeast, Minneapolis, Minnesota 55455, USA
    Chem Res Toxicol 21:746-51. 2008
    ..These results demonstrate that NDMA, NNK, and NNAL have the potential to be bident carcinogens, damaging DNA through the metabolic formation of both diazonium ions and formaldehyde...

Research Grants49

  1. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..The major strengths include the need for a randomized, placebo-controlled trial of PEITC, the qualification of the investigators, and the feasibility of the proposed studies. ..
  2. Biomarkers of Exposure to and Health Effects from SHS in Outdoor Smoking Areas
    Luke P Naeher; Fiscal Year: 2011
    ..These data are important for human health risk assessment and policy making relevant to SHS exposures in these outdoor settings - an area of growing public health concern. ..
  3. Liquid Chromatograph-Triple Quadrupole Mass Spectrometer
    Peyton Jacob; Fiscal Year: 2010
    ..The research projects supported by our resource are developing improved therapies for tobacco addiction, or are investigating exposure to secondhand tobacco smoke in order to reduce its adverse health consequences. ..
  4. Biomarkers of toxic response to low nicotine cigarette smoke
    Andrew Strasser; Fiscal Year: 2012
    ..A panel of biomarkers will be developed, which will show whether individuals have a toxic response to smoking low nicotine cigarettes and whether the toxic response is different from smoking conventional cigarettes. ..
  5. Alcohol induced enrichment of regulatory T cells
    Makio Iwashima; Fiscal Year: 2010
    ..This study will analyze is this effect is mediated by inhibition of an enzyme called phospholipase D using genetically manipulated mice that lack expression of this enzyme. ..
  6. Cigarette Smoke Exposure and Acute Lung Injury After Severe Blunt Trauma
    CAROLYN CALFEE; Fiscal Year: 2013
    ....
  7. ACTIVE SPECIFIC IMMUNOTHERAPY IN MAN--A MURINE MODEL
    Barry Kahan; Fiscal Year: 1992
    ..The proposed studies thus proffer a molecular approach to dissect potential antigens augmenting host resistance for active specific immunotherapy...
  8. NO as a Sensor of Gene Expression Differences: Application to Synthetic Biology
    RYAN JOSEPH MARCHESCHI; Fiscal Year: 2013
    ....
  9. THE ROLE OF TOBACCO-SPECIFIC NITROSAMINES IN PANCREATIC CANCER
    Bogdan Prokopczyk; Fiscal Year: 2007
    ..The result of this study will further support the role of cigarette smoking and underscore the likelihood of dietary fat as a modulator of the development of human pancreatic cancer that is suggested by epidemiological observations. ..
  10. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  11. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  12. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  13. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  14. CHEMICAL SENSORY IRRITATION: CONTRAST WITH OLFACTION
    J Enrique Cometto Muniz; Fiscal Year: 2010
    ..The outcome will allow us to make inferences about the relative breadth of chemical tuning in human olfaction and chemesthesis. ..
  15. Molecular Boundaries For Trigeminal Chemosensory Impact
    J Cometto Muniz; Fiscal Year: 2006
    ..abstract_text> ..
  16. Topical Treatment for Mild Psoriasis
    Wendy Bollag; Fiscal Year: 2007
    ..An effective, easy-to-use, low-cost therapy suitable for long-term relief would be a great boon. [unreadable] [unreadable] [unreadable] [unreadable]..
  17. THE SINGAPORE COHORT STUDY OF DIET AND CANCER
    Jian Min Yuan; Fiscal Year: 2009
    ....
  18. Ethanol and cholesterol homeostasis in the brain
    Marina Guizzetti; Fiscal Year: 2006
    ..abstract_text> ..
  19. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..In all instances of diet-cancer investigations, relevant genes with potential modifying effects on the respective diet-cancer associations will be included in the investigations. ..
  20. PHOSPHOLIPASE D AND KERATINOCYTE DIFFERENTIATION
    Wendy Bollag; Fiscal Year: 2007
    ..abstract_text> ..
  21. Regularity Mechanisms of Aldosterone Secretion
    Wendy Bollag; Fiscal Year: 2006
    ..The complex interactions between AngII and serum K+ levels suggest that abnormalities in the glomerulosa cell response to either agonist, or both, may contribute to the development of some forms of hypertension. [unreadable] [unreadable]..
  22. Dietary Factors in the Etiology of Colorectal Cancer
    Jian Min Yuan; Fiscal Year: 2008
    ..The potential modifying effects of HAA activating genes and tea polyphenols on the HAA-colorectal cancer association will be explored. [unreadable] [unreadable]..
  23. Interventions for Tobacco Dependent Adolescents
    Dorothy Hatsukami; Fiscal Year: 2005
    ....
  24. Pressure-Based Pharmacological Alcoholism Treatments
    DARYL DAVIES; Fiscal Year: 2005
    ..These agents can form the bases of novel prevention and treatment strategies for alcoholism and alcohol abuse. ..
  25. Nitric Oxide Interaction with Red Blood Cells
    James C Liao; Fiscal Year: 2010
    ..Specific aim 2 will focus on the functional roles of this regulation using isolated porcine pulmonary and coronary microvessels. Together, these results will suggest clinical relevance and potential interventions. ..
  26. Synthetic Reactions Catalyzed by Transition Metals
    Ei ichi Negishi; Fiscal Year: 2010
    ..Being considered for this purpose are discodermolide, hennoxazole A, zincophorin, roselipins, apoptolidin, nafuredin, caIlystatin A, milbemycin p3, calyculin A, and amphotericin B. ..
  27. Sites and Mechanisms of Ethanol Action in P2X receptors
    DARYL DAVIES; Fiscal Year: 2009
    ....
  28. STUDY ON A NOVEL ALZHEIMER APP REGULATORY FACTOR
    Wolfgang Quitschke; Fiscal Year: 2006
    ..One ultimate goal of this research is to control APP gene expression in vivo by altering the interaction of activating factors with the APP promoter. ..
  29. Chemoprevention of Tobacco Related Cancer in Animals
    Michael Pereira; Fiscal Year: 2004
    ....
  30. TIMING OF SMOKING INTERVENTION IN ALCOHOL TREATMENT
    ANNE JOSEPH; Fiscal Year: 2001
    ....
  31. DETERMINANTS OF PERCEPTION WITH A COCHLEAR IMPLANT
    David Smith; Fiscal Year: 2001
    ..In addition, the feasibility of conducting fine focal stimulation within the cochlea, both within and across a critical band length, will be evaluated in terms of measures of channel interactions and behavioral performance. ..
  32. TOBACCO EXPOSURE REDUCTION
    Dorothy Hatsukami; Fiscal Year: 2008
    ..The results of research from this TTURC will provide the scientific basis for urgent policy, public education, and regulatory efforts to reduce tobacco harm. ..
  33. Safety of Nicotine Reduction Strategy
    Neal Benowitz; Fiscal Year: 2009
    ..The proposed research is needed to guide governmental regulators as to how best to regulate nicotine in cigarettes and is an essential first step in examining the feasibility of a national regulation program. ..
  34. TREATMENT OF SMOKELESS TOBACCO USERS
    Dorothy Hatsukami; Fiscal Year: 2008
    ..PERFORMANCE SITE ========================================Section End=========================================== ..
  35. Analysis of 5'UTR-Mediated Regulation of p53 Expression
    Philip Lazarus; Fiscal Year: 2006
    ..abstract_text> ..
  36. Automated Chip-Based Metabolomic Analysis
    James Liao; Fiscal Year: 2006
    ..abstract_text> ..
  37. Inhibition of Macrophage Innate Immunity in Tuberculosis
    WILLIAM NAUSEEF; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  38. ASTHMA HEALTH OUTCOMES FOLLOWING INTENSIVE CARE
    Mark Eisner; Fiscal Year: 2004
    ..This award will enable Dr. Eisner's continued progression to an independent clinical investigator. ..
  39. Psychophysicial Studies of Cochlear Efferent Function
    David Smith; Fiscal Year: 2005
    ..Without this parallel testing paradigm (and the ability to lesion tracts in the non-human primate subjects) the link between human perception and the underlying neural mechanism would not be direction obtainable. ..
  40. Engineering Large scale pathways from organisms to Escherichia coli
    James Liao; Fiscal Year: 2008
    ..In particular, selected projects proposed here will be used as modules in a workshop established by FRT at Ohio State and form the basis for a course (Metabolic Engineering) at UCLA. ..
  41. Individual Differences in Olfaction
    CHARLES WYSOCKI; Fiscal Year: 2008
    ..To do this, we will assess individual behavioral responses to odors and characterize the genes for olfactory receptors that are found within the person's genome. ..
  42. Phospholipase D and the Actin Cytoskeleton
    DAVID KUSNER; Fiscal Year: 2005
    ..These studies will further both our specific knowledge of signal transduction mechanisms that regulate inflammation as well as our more general understanding of the spatial and temporal determinants of cellular activation and motility. ..
  43. Disability and Health Outcomes in COPD
    Mark Eisner; Fiscal Year: 2008
    ..Based on this work, intervention strategies can be designed that target reduction of functional limitation and disability to improve downstream health outcomes. ..
  44. Determinants of the Durability of Resin-Dentin Bonds
    David Pashley; Fiscal Year: 2006
    ..This should provide important new insight into designing more durable resin-dentin bonds that can justify the placement of resin-based posterior composites. ..
  45. Innovative Interventions for Smoking Cessation
    Dorothy K Hatsukami; Fiscal Year: 2010
    ..The results of this study will provide useful information on directions to pursue to improve our pharmacotherapies and behavioral treatments and to better understand the various aspects of addiction. ..
  46. Temporal Integration in Nasal Lateralization
    Paul Wise; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  47. PET AND THE BLOOD BRAIN BARRIER IN HUMAN EPILEPSY
    EAIN CORNFORD; Fiscal Year: 2002
    ..abstract_text> ..
  48. Chemogenomic Analysis of E. coli Response to NO species
    James C Liao; Fiscal Year: 2010
    ..If hew TF targets are predicted, then the iteration continues. Otherwise, the predicted networks are verified using genetic and biochemical experiments. ..
  49. Blood-brain barrier gene delivery in knock-out mice.
    EAIN CORNFORD; Fiscal Year: 2005
    ..abstract_text> ..