dietary fats

Summary

Summary: Fats present in food, especially in animal products such as meat, meat products, butter, ghee. They are present in lower amounts in nuts, seeds, and avocados.

Top Publications

  1. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
  2. pmc Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 117:175-84. 2007
  3. pmc MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1494-505. 2006
  4. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
  5. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
  6. ncbi A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease
    Andrew Mente
    Population Health Research Institute, Hamilton General Hospital, 4 East Room 441, 237 Barton St E, Hamilton, ON L8L 2X2, Canada
    Arch Intern Med 169:659-69. 2009
  7. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
  8. ncbi Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Prog Lipid Res 47:348-80. 2008
  9. ncbi Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    Daniela M L Tsukumo
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Diabetes 56:1986-98. 2007
  10. ncbi Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Diabetes 56:16-23. 2007

Detail Information

Publications297 found, 100 shown here

  1. ncbi Metabolic endotoxemia initiates obesity and insulin resistance
    Patrice D Cani
    Institute of Molecular Medicine, I2MR Toulouse, France
    Diabetes 56:1761-72. 2007
    ..We conclude that the LPS/CD14 system sets the tone of insulin sensitivity and the onset of diabetes and obesity. Lowering plasma LPS concentration could be a potent strategy for the control of metabolic diseases...
  2. pmc Obesity induces a phenotypic switch in adipose tissue macrophage polarization
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, USA
    J Clin Invest 117:175-84. 2007
    ..Thus, diet-induced obesity leads to a shift in the activation state of ATMs from an M2-polarized state in lean animals that may protect adipocytes from inflammation to an M1 proinflammatory state that contributes to insulin resistance...
  3. pmc MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity
    Hajime Kanda
    Department of Clinical Molecular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan
    J Clin Invest 116:1494-505. 2006
    ..These findings suggest that an increase in MCP-1 expression in adipose tissue contributes to the macrophage infiltration into this tissue, insulin resistance, and hepatic steatosis associated with obesity in mice...
  4. ncbi Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha
    Marie Lagouge
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 67404 Illkirch, France
    Cell 127:1109-22. 2006
    ..These pharmacological effects of RSV combined with the association of three Sirt1 SNPs and energy homeostasis in Finnish subjects implicates SIRT1 as a key regulator of energy and metabolic homeostasis...
  5. pmc Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
    Justin I Odegaard
    Division of Endocrinology, Metabolism and Gerontology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94305 5103, USA
    Nature 447:1116-20. 2007
    ....
  6. ncbi A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease
    Andrew Mente
    Population Health Research Institute, Hamilton General Hospital, 4 East Room 441, 237 Barton St E, Hamilton, ON L8L 2X2, Canada
    Arch Intern Med 169:659-69. 2009
    ..Although a wealth of literature links dietary factors and coronary heart disease (CHD), the strength of the evidence supporting valid associations has not been evaluated systematically in a single investigation...
  7. ncbi Selective increases of bifidobacteria in gut microflora improve high-fat-diet-induced diabetes in mice through a mechanism associated with endotoxaemia
    P D Cani
    Unit of Pharmacokinetics, Metabolism, Nutrition and Toxicology, Universite Catholique de Louvain, Av E Mounier, 73 69, 1200 Brussels, Belgium
    Diabetologia 50:2374-83. 2007
    ..caecal content in mice. We therefore tested whether restoration of the quantity of caecal Bifidobacterium spp. could modulate metabolic endotoxaemia, the inflammatory tone and the development of diabetes...
  8. ncbi Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake
    Leanne Hodson
    Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, Oxford OX3 7LJ, UK
    Prog Lipid Res 47:348-80. 2008
    ..The relationship between plasma lipoprotein concentrations and total plasma fatty acid composition, and the use of fatty acid ratios as indices of enzyme activity are also addressed...
  9. ncbi Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
    Daniela M L Tsukumo
    Department of Internal Medicine, State University of Campinas, Campinas, Sao Paulo, Brazil
    Diabetes 56:1986-98. 2007
    ..Thus, TLR4 appears to be an important mediator of obesity and insulin resistance and a potential target for the therapy of these highly prevalent medical conditions...
  10. ncbi Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity
    Carey N Lumeng
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    Diabetes 56:16-23. 2007
    ..In agreement with this, ATMs from obese mice had increased lipid content compared with those from lean mice. These studies demonstrate that recruited ATMs in obese animals represent a subclass of macrophages with unique properties...
  11. pmc Comparison of weight-loss diets with different compositions of fat, protein, and carbohydrates
    Frank M Sacks
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    N Engl J Med 360:859-73. 2009
    ..The possible advantage for weight loss of a diet that emphasizes protein, fat, or carbohydrates has not been established, and there are few studies that extend beyond 1 year...
  12. pmc Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB
    Dongsheng Cai
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, One Joslin Place, Boston, Massachusetts 02215, USA
    Nat Med 11:183-90. 2005
    ..These findings indicate that lipid accumulation in the liver leads to subacute hepatic 'inflammation' through NF-kappaB activation and downstream cytokine production. This causes insulin resistance both locally in liver and systemically...
  13. ncbi Environmental contributions to the obesity epidemic
    J O Hill
    Colorado Clinical Nutrition Research Unit, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    Science 280:1371-4. 1998
    ..Because obesity is difficult to treat, public health efforts need to be directed toward prevention...
  14. ncbi Developmental origin of fat: tracking obesity to its source
    Stephane Gesta
    Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215, USA
    Cell 131:242-56. 2007
    ..In this Review, we consider how the developmental origins of fat contribute to its physiological, cellular, and molecular heterogeneity and explore how these factors may play a role in the growing epidemic of obesity...
  15. pmc Mitochondrial dysfunction results from oxidative stress in the skeletal muscle of diet-induced insulin-resistant mice
    Charlotte Bonnard
    INSERM, U870, IFR62, Oullins, France
    J Clin Invest 118:789-800. 2008
    ..These data suggest that mitochondrial alterations do not precede the onset of insulin resistance and result from increased ROS production in muscle in diet-induced diabetic mice...
  16. pmc High-fat diet determines the composition of the murine gut microbiome independently of obesity
    Marie A Hildebrandt
    Division of Gastroenterology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    Gastroenterology 137:1716-24.e1-2. 2009
    ..The composition of the gut microbiome is affected by host phenotype, genotype, immune function, and diet. Here, we used the phenotype of RELMbeta knockout (KO) mice to assess the influence of these factors...
  17. ncbi A transgenic model of visceral obesity and the metabolic syndrome
    H Masuzaki
    Division of Endocrinology and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA
    Science 294:2166-70. 2001
    ..Increased adipocyte 11beta HSD-1 activity may be a common molecular etiology for visceral obesity and the metabolic syndrome...
  18. ncbi Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    M Elchebly
    Department of Biochemistry, McGill University, 3655 Drummond Street, Montreal, Quebec, Canada, H3G 1Y6
    Science 283:1544-8. 1999
    ..These results demonstrate that PTP-1B has a major role in modulating both insulin sensitivity and fuel metabolism, thereby establishing it as a potential therapeutic target in the treatment of type 2 diabetes and obesity...
  19. pmc The gut microbiota as an environmental factor that regulates fat storage
    Fredrik Backhed
    Center for Genome Sciences and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:15718-23. 2004
    ..Data deposition: The sequences reported in this paper have been deposited in the GenBank database (accession nos. AY 667702--AY 668946)...
  20. pmc Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates
    Carrie E McCurdy
    Department of Pediatrics, University of Colorado Denver, Aurora, Colorado 80045, USA
    J Clin Invest 119:323-35. 2009
    ..These results suggest that a developing fetus is highly vulnerable to excess lipids, independent of maternal diabetes and/or obesity, and that exposure to this may increase the risk of pediatric NAFLD...
  21. pmc Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity
    James M Ntambi
    Department of Biochemistry, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 99:11482-6. 2002
    ..These observations suggest that a consequence of SCD1 deficiency is an activation of lipid oxidation in addition to reduced triglyceride synthesis and storage...
  22. pmc The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects
    Marta Yanina Pepino
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    J Lipid Res 53:561-6. 2012
    ..of orlistat, a lipase inhibitor, to reduce FA release from triacylglycerols (TGs), the main component of dietary fats, would attenuate fat orosensory sensitivity in humans...
  23. ncbi Tlr-4 deficiency selectively protects against obesity induced by diets high in saturated fat
    Jeremy E Davis
    Department of Food Science and Human Nutrition, Iowa State University, Ames, Iowa, USA
    Obesity (Silver Spring) 16:1248-55. 2008
    ..These data indicate that Tlr-4 deficiency selectively protects against the obesigenic effects of SFA and alters obesity-related inflammatory responses in adipose tissue...
  24. pmc Major types of dietary fat and risk of coronary heart disease: a pooled analysis of 11 cohort studies
    Marianne U Jakobsen
    Research Unit for Dietary Studies at the Institute of Preventive Medicine, Copenhagen University Hospital, Centre for Health and Society, Copenhagen, Denmark
    Am J Clin Nutr 89:1425-32. 2009
    ..Lower habitual intakes of SFAs, however, require substitution of other macronutrients to maintain energy balance...
  25. pmc Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes
    Jill C Milne
    Sirtris Pharmaceuticals Inc, 790 Memorial Drive, Cambridge, Massachusetts 02139, USA
    Nature 450:712-6. 2007
    ..Thus, SIRT1 activation is a promising new therapeutic approach for treating diseases of ageing such as type 2 diabetes...
  26. ncbi T-lymphocyte infiltration in visceral adipose tissue: a primary event in adipose tissue inflammation and the development of obesity-mediated insulin resistance
    Ulrich Kintscher
    Department of Internal Medicine II Cardiology, University of Ulm, Robert Koch Str 8, D 89081 Ulm, Germany
    Arterioscler Thromb Vasc Biol 28:1304-10. 2008
    ..Adipose tissue inflammation may play a critical role in the pathogenesis of insulin resistance (IR). The present study examined the role of lymphocytes in adipose tissue inflammation and IR...
  27. pmc Obesity-induced insulin resistance and hepatic steatosis are alleviated by omega-3 fatty acids: a role for resolvins and protectins
    Ana González-Périz
    Department of Biochemistry and Molecular Genetics, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, University of Barcelona, Barcelona, Spain
    FASEB J 23:1946-57. 2009
    ..Taken together, these findings uncover beneficial actions of omega-3-PUFAs and their bioactive lipid autacoids in preventing obesity-induced insulin resistance and hepatic steatosis...
  28. ncbi n-6 fatty acid-specific and mixed polyunsaturate dietary interventions have different effects on CHD risk: a meta-analysis of randomised controlled trials
    Christopher E Ramsden
    Section on Nutritional Neurosciences, Laboratory of Membrane Biochemistry and Biophysics, NIAAA, NIH, Bethesda, MD, USA
    Br J Nutr 104:1586-600. 2010
    ..16; 95 % CI 0.95, 1.42). Advice to specifically increase n-6 PUFA intake, based on mixed n-3/n-6 RCT data, is unlikely to provide the intended benefits, and may actually increase the risks of CHD and death...
  29. pmc Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice
    Maziyar Saberi
    Department of Medicine, Division of Endocrinology and Metabolism, University of California, San Diego, La Jolla, CA 92093, USA
    Cell Metab 10:419-29. 2009
    ..In summary, our results indicate that Tlr4 signaling in hematopoietic-derived cells is important for the development of hepatic and adipose tissue insulin resistance in obese mice...
  30. ncbi Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action
    R C Frederich
    Division of Endocrinology, Beth Israel Hospital Research North, Boston, Massachusetts 02215, USA
    Nat Med 1:1311-4. 1995
    ....
  31. ncbi Essential fatty acids in health and chronic disease
    A P Simopoulos
    Center for Genetics, Nutrition and Health, Washington, DC 20009
    Am J Clin Nutr 70:560S-569S. 1999
    ....
  32. ncbi High-fat diet-induced obesity in animal models
    Niloofar Hariri
    School of Dietetics and Human Nutrition, McGill University, Quebec, Canada
    Nutr Res Rev 23:270-99. 2010
    ..diets to induce obesity in animals, aims to clarify the consequences of changing the amount and type of dietary fats on weight gain, body composition and adipose tissue cellularity, and explores the contribution of genetics and ..
  33. pmc Effects on coronary heart disease of increasing polyunsaturated fat in place of saturated fat: a systematic review and meta-analysis of randomized controlled trials
    Dariush Mozaffarian
    Division of Cardiovascular Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS Med 7:e1000252. 2010
    ..Additionally, some public health groups recommend lowering or limiting polyunsaturated fat (PUFA) consumption, a major potential replacement for SFA...
  34. pmc MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity
    Andre Kleinridders
    Department of Mouse Genetics and Metabolism, Institute for Genetics, Cologne Excellence Cluster on Cellular Stress Responses in Aging Associated Diseases CECAD and Center of Molecular Medicine Cologne CMMC, University of Cologne, D 50674 Cologne, Germany
    Cell Metab 10:249-59. 2009
    ..Thus, we define neuronal MyD88-dependent signaling as a key regulator of diet-induced leptin and insulin resistance in vivo...
  35. pmc Dietary fats and prevention of type 2 diabetes
    Ulf Riserus
    Clinical Nutrition and Metabolism, Department of Public Health and Caring Sciences, Faculty of Medicine, Uppsala University, Uppsala Science Park, 75185 Uppsala, Sweden
    Prog Lipid Res 48:44-51. 2009
    ..It also summarizes controlled feeding studies on the effects of dietary fats on metabolic mediators, such as insulin resistance...
  36. pmc Chronic consumption of a high-fat diet during pregnancy causes perturbations in the serotonergic system and increased anxiety-like behavior in nonhuman primate offspring
    Elinor L Sullivan
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, Beaverton, Oregon 97006, USA
    J Neurosci 30:3826-30. 2010
    ..These findings have important clinical implications as they demonstrate that exposure to maternal HFD consumption during gestation, independent of obesity, increases the risk of developing behavioral disorders such as anxiety...
  37. ncbi Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids
    Yuriko Adkins
    Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA
    J Nutr Biochem 21:781-92. 2010
    ..This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD...
  38. ncbi Toll-like receptor-4 mediates vascular inflammation and insulin resistance in diet-induced obesity
    Francis Kim
    Department of Medicine, University of Washington, Seattle, WA 98104, USA
    Circ Res 100:1589-96. 2007
    ....
  39. ncbi Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: role of fat and carbohydrate meals
    Francesco Nappo
    Department of Geriatrics and Metabolic Diseases, Second University of Naples, Naples, Italy
    J Am Coll Cardiol 39:1145-50. 2002
    ..To compare the effect of a high-fat meal and a high-carbohydrate meal (pizza), with and without antioxidant vitamins, on endothelial activation in healthy subjects and in patients with type 2 diabetes mellitus...
  40. pmc Maternal high-fat diet alters methylation and gene expression of dopamine and opioid-related genes
    Zivjena Vucetic
    University of Pennsylvania School of Medicine, Department of Pharmacology, Institute for Translational Medicine and Therapeutics, School of Medicine, 805 Biomedical Research Building II III, 421 Curie Boulevard, Philadelphia, Pennsylvania 19104 6160, USA
    Endocrinology 151:4756-64. 2010
    ....
  41. ncbi Defining high-fat-diet rat models: metabolic and molecular effects of different fat types
    R Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    J Mol Endocrinol 36:485-501. 2006
    ..Diets based on LC-SFA and MUFA induced hepatic steatosis with SREBP1c activation. This points to an intact transcriptional hepatic insulin effect despite resistance to insulin's metabolic actions...
  42. pmc SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1
    Michelle Pacholec
    Department of Cardiovascular, Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    J Biol Chem 285:8340-51. 2010
    ..Taken together, we conclude that SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1...
  43. ncbi The high-fat diet-fed mouse: a model for studying mechanisms and treatment of impaired glucose tolerance and type 2 diabetes
    Maria Sörhede Winzell
    Dept of Medicine, Biomedical Center BMC, B11, S 221 84 Lund, Sweden
    Diabetes 53:S215-9. 2004
    ..We conclude that the high-fat diet-fed C57BL/6J mouse model is a robust model for IGT and early type 2 diabetes, which may be used for studies on pathophysiology and development of new treatment...
  44. ncbi Crucial role of a long-chain fatty acid elongase, Elovl6, in obesity-induced insulin resistance
    Takashi Matsuzaka
    Department of Internal Medicine Endocrinology and Metabolism Graduate School of Comprehensive Human Sciences, 1 1 1 Tennodai, Tsukuba Ibaraki 305 8575, Japan
    Nat Med 13:1193-202. 2007
    ..Inhibition of this elongase could be a new therapeutic approach for ameliorating insulin resistance, diabetes and cardiovascular risks, even in the presence of a continuing state of obesity...
  45. ncbi Crossover study of diets enriched with virgin olive oil, walnuts or almonds. Effects on lipids and other cardiovascular risk markers
    N R T Damasceno
    Lipid Clinic, Endocrinology and Nutrition Service, Biomedical Research Institute August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Nutr Metab Cardiovasc Dis 21:S14-20. 2011
    ..We designed a study in hypercholesterolemic patients to assess the effects on serum lipids and other intermediate markers of cardiovascular risk of replacing 40% of the fat in the background diet with VOO, walnuts or almonds...
  46. pmc The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010?
    Arne Astrup
    Department of Human Nutrition, Faculty of Life Sciences, University of Copenhagen, Denmark
    Am J Clin Nutr 93:684-8. 2011
    ..Research is needed to clarify the role of SFAs compared with specific forms of carbohydrates in CHD risk and to compare specific foods with appropriate alternatives...
  47. ncbi Dietary monounsaturated fatty acids are protective against metabolic syndrome and cardiovascular disease risk factors
    Leah G Gillingham
    Department of Human Nutritional Sciences, Richardson Centre for Functional Foods and Nutraceuticals, University of Manitoba, 196 Innovation Drive, Winnipeg, MB, R3T 2N2, Canada
    Lipids 46:209-28. 2011
    ..As the debate on the optimal fatty acid composition of the diet continues, the benefit of increasing MUFA intakes, particularly as a substitute for dietary SFA, deserves considerable attention...
  48. ncbi Diet and risk of Type II diabetes: the role of types of fat and carbohydrate
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Diabetologia 44:805-17. 2001
    ..Dietary recommendations to prevent Type II diabetes should focus more on the quality of fat and carbohydrate in the diet than quantity alone, in addition to balancing total energy intake with expenditure to avoid overweight and obesity...
  49. ncbi C3H/HeJ mice carrying a toll-like receptor 4 mutation are protected against the development of insulin resistance in white adipose tissue in response to a high-fat diet
    M Poggi
    INSERM UMR 626 Faculté de Médecine Timone, 27 Boulevard Jean Moulin, 13385 Marseille Cedex 5, France
    Diabetologia 50:1267-76. 2007
    ..Our aim was to determine what role TLR4 plays in the development of metabolic phenotypes during high-fat feeding...
  50. ncbi JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
    Giovanni Solinas
    Department of Medicine, University of Fribourg, Chemin du Musee 5, CH 1700 Fribourg, Switzerland
    Cell Metab 6:386-97. 2007
    ..By contrast, Jnk1 removal from hematopoietic cells has no effect on adiposity but confers protection against HFD-induced insulin resistance by decreasing obesity-induced inflammation...
  51. ncbi Kupffer cell activation is a causal factor for hepatic insulin resistance
    Nicolas Lanthier
    Laboratoire de gastro entérologie, Universite Catholique de Louvain, GAEN 53 79, Ave Mounier 53, B 1200 Brussels, Belgium
    Am J Physiol Gastrointest Liver Physiol 298:G107-16. 2010
    ....
  52. ncbi Cardiovascular disease risk of dietary stearic acid compared with trans, other saturated, and unsaturated fatty acids: a systematic review
    J Edward Hunter
    Department of Chemistry University of Cincinnati Cincinnati OH 45221 0172, USA
    Am J Clin Nutr 91:46-63. 2010
    ..High stearic acid (STA) soybean oil is a trans-free, oxidatively stable, non-LDL-cholesterol-raising oil that can be used to replace trans fatty acids (TFAs) in solid fat applications...
  53. pmc Maternal nutritional history predicts obesity in adult offspring independent of postnatal diet
    G J Howie
    Liggins Institute and National Research Centre for Growth and Development, University of Auckland, Grafton, Auckland, New Zealand
    J Physiol 587:905-15. 2009
    ....
  54. ncbi Substituting dietary saturated for monounsaturated fat impairs insulin sensitivity in healthy men and women: The KANWU Study
    B Vessby
    Unit for Clinical Nutrition Research, Department of Public Health and Caring Sciences/Geriatrics, University of Uppsala, Uppsala, Sweden
    Diabetologia 44:312-9. 2001
    ..A beneficial impact of the fat quality on insulin sensitivity is not seen in individuals with a high fat intake (> 37E%)...
  55. pmc Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet--induced obesity in mice
    Merav E Shaul
    Obesity and Metabolism Laboratory, Jean Mayer U S Department of Agriculture Human Nutrition Research Center on Aging, Tufts University, Boston, Massachusetts, USA
    Diabetes 59:1171-81. 2010
    ..To identify, localize, and determine M1/M2 polarization of epidydimal adipose tissue (eAT) macrophages (Phis) during high-fat diet (HFD)-induced obesity...
  56. ncbi Role of STAT-3 in regulation of hepatic gluconeogenic genes and carbohydrate metabolism in vivo
    Hiroshi Inoue
    Department of Clinical Molecular Medicine, Division of Diabetes and Digestive and Kidney Diseases, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Nat Med 10:168-74. 2004
    ..Hepatic STAT-3 signaling is thus essential for normal glucose homeostasis and may provide new therapeutic targets for diabetes mellitus...
  57. pmc Severe NAFLD with hepatic necroinflammatory changes in mice fed trans fats and a high-fructose corn syrup equivalent
    Laura H Tetri
    Department of Internal Medicine, Saint Louis University, MO, USA
    Am J Physiol Gastrointest Liver Physiol 295:G987-95. 2008
    ..Because dietary trans fats promoted liver steatosis and injury, their role in the epidemic of NASH needs further evaluation...
  58. pmc CCR2 modulates inflammatory and metabolic effects of high-fat feeding
    Stuart P Weisberg
    Department of Medicine, Naomi Berrie Diabetes Center, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    J Clin Invest 116:115-24. 2006
    ....
  59. ncbi Optimal diets for prevention of coronary heart disease
    Frank B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 288:2569-78. 2002
    ..Thus, identification of the dietary changes that most effectively prevent CHD is critical...
  60. ncbi Dietary intake of dairy products, calcium, and vitamin D and the risk of hypertension in middle-aged and older women
    Lu Wang
    Division of Preventive Medicine, Harvard School of Public Health, Boston, Mass, USA harvard edu
    Hypertension 51:1073-9. 2008
    ....
  61. ncbi Carbohydrate-induced hypertriacylglycerolemia: historical perspective and review of biological mechanisms
    E J Parks
    Department of Food Science and Nutrition, University of Minnesota Twin Cities, St Paul, MN 55108 6099, USA
    Am J Clin Nutr 71:412-33. 2000
    ....
  62. ncbi Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance
    Nozomu Kamei
    Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113 8655, Japan
    J Biol Chem 281:26602-14. 2006
    ..We concluded that both paracrine and endocrine effects of MCP-1 may contribute to the development of insulin resistance in aP2-MCP-1 mice...
  63. ncbi Developmental origins of obesity and the metabolic syndrome: the role of maternal obesity
    James Andrew Armitage
    Department of Anatomy and Developmental Biology, Monash University, Clayton, Vic, Australia
    Front Horm Res 36:73-84. 2008
    ..This chapter discusses the effects of maternal obesity on fetal development and birth outcomes as well as the manner in which DOHaD may contribute to the obesity epidemic...
  64. ncbi Energy intake is associated with endotoxemia in apparently healthy men
    Jacques Amar
    INSERM 558, Toulouse, France
    Am J Clin Nutr 87:1219-23. 2008
    ..The bridge between food intake and weight is not fully understood. Recently, the role of gut microbiota and bacterial lipopolysacharides (LPS) in weight has been noted...
  65. ncbi High-fat diets: modeling the metabolic disorders of human obesity in rodents
    Roland Buettner
    Department of Internal Medicine I, University of Regensburg, 93042 Regensburg, Germany
    Obesity (Silver Spring) 15:798-808. 2007
    ..Therefore, in this review, metabolic data obtained with different HF diet approaches are compiled. Both whole-body and organ-specific diet effects are analyzed...
  66. ncbi IKK-beta links inflammation to obesity-induced insulin resistance
    Melek C Arkan
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093, USA
    Nat Med 11:191-8. 2005
    ..We suggest that inhibition of IKK-beta, especially in myeloid cells, may be used to treat insulin resistance...
  67. pmc Endocannabinoid activation at hepatic CB1 receptors stimulates fatty acid synthesis and contributes to diet-induced obesity
    Douglas Osei-Hyiaman
    National Institute on Alcohol Abuse and Alcoholism, NIH, Bethesda, Maryland 20892, USA
    J Clin Invest 115:1298-305. 2005
    ..We conclude that anandamide acting at hepatic CB(1) contributes to diet-induced obesity and that the FAS pathway may be a common molecular target for central appetitive and peripheral metabolic regulation...
  68. ncbi Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression
    Kimberley D Bruce
    Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, UK
    Hepatology 50:1796-808. 2009
    ..In addition, measurement of hepatic gene expression indicated that lipogenesis, oxidative stress, and inflammatory pathways were up-regulated in the 15-week-old HF/C and HF/HF offspring...
  69. pmc Integrated hepatic transcriptome and proteome analysis of mice with high-fat diet-induced nonalcoholic fatty liver disease
    Irina A Kirpich
    Department of Internal Medicine, Division of Gastroenterology, Hepatology and Nutrition, University of Louisville, Louisville, KY 40202, USA
    J Nutr Biochem 22:38-45. 2011
    ..These pathways provide targets for future mechanistic and therapeutic studies as related to the development and prevention of NAFLD...
  70. ncbi Variation in type 2 diabetes--related traits in mouse strains susceptible to diet-induced obesity
    Martin Rossmeisl
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Diabetes 52:1958-66. 2003
    ..In conclusion, phenotypic variation in insulin resistance and glucose production in the B6 and AKR strains could provide a genetic system for the identification of genes controlling glucose homeostasis...
  71. ncbi Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta
    M Yuan
    Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA 02215, USA
    Science 293:1673-7. 2001
    ..These findings implicate an inflammatory process in the pathogenesis of insulin resistance in obesity and type 2 diabetes mellitus and identify the IKKbeta pathway as a target for insulin sensitization...
  72. ncbi Rutin attenuates metabolic changes, nonalcoholic steatohepatitis, and cardiovascular remodeling in high-carbohydrate, high-fat diet-fed rats
    Sunil K Panchal
    Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, QLD 4350, Australia
    J Nutr 141:1062-9. 2011
    ..These results suggest a non-nutritive role for rutin to attenuate chronic changes in metabolic syndrome...
  73. pmc Dose-dependent effects of dietary fat on development of obesity in relation to intestinal differential gene expression in C57BL/6J mice
    Nicole J W de Wit
    Netherlands Nutrigenomics Centre, Top Institute Food and Nutrition, Wageningen, The Netherlands
    PLoS ONE 6:e19145. 2011
    ..From 30E% of dietary fat, a switch towards an obese phenotype is triggered. We further speculate that especially fat-dose dependently changed lipid metabolism-related genes are involved in development of obesity...
  74. pmc Metabolic profiling reveals a contribution of gut microbiota to fatty liver phenotype in insulin-resistant mice
    Marc Emmanuel Dumas
    Department of Biological Chemistry, Imperial College London, South Kensington, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 103:12511-6. 2006
    ..These data also indicate that gut microbiota may play an active role in the development of insulin resistance...
  75. ncbi Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    Sung Hee Um
    Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, 4058 Basel, Switzerland
    Nature 431:200-5. 2004
    ..Thus under conditions of nutrient satiation S6K1 negatively regulates insulin signalling...
  76. ncbi Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus
    Claudio T De Souza
    Department of Internal Medicine, State University of Campinas, Campinas SP 13083 970, Brazil
    Endocrinology 146:4192-9. 2005
    ..We conclude that HL feeding induces a local proinflammatory status in the hypothalamus, which results in impaired anorexigenic insulin signaling...
  77. ncbi High-carbohydrate, high-fat diet-induced metabolic syndrome and cardiovascular remodeling in rats
    Sunil K Panchal
    Department of Biological and Physical Sciences, University of Southern Queensland, Toowoomba, Queensland, Australia
    J Cardiovasc Pharmacol 57:611-24. 2011
    ..In comparison with other models of diabetes and obesity, this diet-induced model more closely mimics the changes observed in human metabolic syndrome...
  78. ncbi A controlled high-fat diet induces an obese syndrome in rats
    Stephen C Woods
    Department of Psychiatry, University of Cincinnati School of Medicine, OH 45267, USA
    J Nutr 133:1081-7. 2003
    ..This model of diet-induced obesity will be a useful tool for studying the mechanisms by which dietary fat influences the regulation of energy balance...
  79. ncbi Diet as a risk factor for atopy and asthma
    Graham Devereux
    Department of Environmental and Occupational Medicine, University of Aberdeen, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, Scotland, UK
    J Allergy Clin Immunol 115:1109-17; quiz 1118. 2005
    ..Further research to determine whether dietary intervention can reduce the risk of asthma and atopic disease is justified...
  80. ncbi Evidence-based nutritional approaches to the treatment and prevention of diabetes mellitus
    J I Mann
    Edgar National Centre for Diabetes Research, Medical and Surgical Sciences, University of Otago, Dunedin, New Zealand
    Nutr Metab Cardiovasc Dis 14:373-94. 2004
  81. pmc Melanin-concentrating hormone 1 receptor-deficient mice are lean, hyperactive, and hyperphagic and have altered metabolism
    Donald J Marsh
    Department of Obesity Research, Animal Pharmacology, and Comparative Medicine, Merck Research Laboratories, Rahway, NJ 07065, USA
    Proc Natl Acad Sci U S A 99:3240-5. 2002
    ..We conclude that MCH1R is a physiologically relevant MCH receptor in mice that plays a role in energy homeostasis through multiple actions on locomotor activity, metabolism, appetite, and neuroendocrine function...
  82. ncbi A high-fat, ketogenic diet induces a unique metabolic state in mice
    Adam R Kennedy
    Division of Endocrinology, Departmentof Medicine, Beth Israel Deaconess Medical Center, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Endocrinol Metab 292:E1724-39. 2007
    ..Additionally, AMP kinase activity was increased, with a corresponding decrease in ACC activity. These data indicate that KD induces a unique metabolic state congruous with weight loss...
  83. ncbi Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice
    Kazue Ohmura
    Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Arterioscler Thromb Vasc Biol 30:193-9. 2010
    ..Natural killer T (NKT) cells, which integrate proinflammatory cytokines, have been demonstrated in the atherosclerotic lesions and in visceral adipose tissue...
  84. pmc Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells
    Xiong Ma
    Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA
    J Hepatol 49:821-30. 2008
    ..In the current study, we evaluated the effect of probiotics, and their mechanisms on diet-induced obesity, steatosis and insulin resistance...
  85. pmc Akt2 is required for hepatic lipid accumulation in models of insulin resistance
    Karla F Leavens
    Department of Medicine, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Cell Metab 10:405-18. 2009
    ..These data demonstrate that Akt2 is a requisite component of the insulin-dependent regulation of lipid metabolism during insulin resistance...
  86. ncbi Dietary fat and obesity: a review of animal, clinical and epidemiological studies
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Physiol Behav 83:549-55. 2004
    ..Thus, dietary fat is an important contributor to obesity in some people...
  87. pmc Saturated fat, carbohydrate, and cardiovascular disease
    Patty W Siri-Tarino
    Department of Atherosclerosis Research Children s Hospital Oakland Research Institute Oakland, CA, USA
    Am J Clin Nutr 91:502-9. 2010
    ....
  88. ncbi Maternal obesity at conception programs obesity in the offspring
    Kartik Shankar
    Arkansas Children s Nutrition Center, 1212 Marshall Street, Little Rock, AR 72202, USA
    Am J Physiol Regul Integr Comp Physiol 294:R528-38. 2008
    ..Our data suggest that maternal obesity at conception leads to fetal programming of offspring, which could result in obesity in later life...
  89. ncbi Dietary fat intakes for pregnant and lactating women
    Berthold Koletzko
    Dr von Hauner Children s Hospital, University of Munich, Germany
    Br J Nutr 98:873-7. 2007
    ....
  90. ncbi Synergistic induction of lipid catabolism and anti-inflammatory lipids in white fat of dietary obese mice in response to calorie restriction and n-3 fatty acids
    P Flachs
    Department of Adipose Tissue Biology, Institute of Physiology Academy of Sciences of the Czech Republic v v i, Videnska 1083, 14220 Prague, Czech Republic
    Diabetologia 54:2626-38. 2011
    ..We aimed to characterise the effectiveness and underlying mechanisms of the combination treatment with LC n-3 PUFA and 10% calorie restriction in the prevention of obesity and associated disorders in mice...
  91. ncbi High-fat diet disrupts behavioral and molecular circadian rhythms in mice
    Akira Kohsaka
    Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208, USA
    Cell Metab 6:414-21. 2007
    ..These results indicate that consumption of a high-calorie diet alters the function of the mammalian circadian clock...
  92. ncbi Bioconversion of vaccenic acid to conjugated linoleic acid in humans
    Anu M Turpeinen
    Department of Applied Chemistry, University of Helsinki, Finland
    Am J Clin Nutr 76:504-10. 2002
    ..There are indications that this conversion also occurs in humans...
  93. ncbi The mammalian low-density lipoprotein receptor family
    M M Hussain
    Department of Biochemistry, MCP Hahnemann University, Philadelphia, Pennsylvania 19129, USA
    Annu Rev Nutr 19:141-72. 1999
    ..It is anticipated that increased knowledge about the LDL-R family members will open new avenues for the treatment of many disorders...
  94. pmc Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle
    Eun Gyoung Hong
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes 58:2525-35. 2009
    ..We examined the role of IL-10 in glucose homeostasis using transgenic mice with muscle-specific overexpression of IL-10 (MCK-IL10)...
  95. pmc CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions
    Fabienne Laugerette
    Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l Alimentation et Centre Européen des Sciences du Goût, UMR 5170 CNRS 1214 INRA Université de Bourgogne, Dijon, France
    J Clin Invest 115:3177-84. 2005
    ..These findings demonstrate that CD36 is involved in oral LCFA detection and raise the possibility that an alteration in the lingual fat perception may be linked to feeding dysregulation...
  96. ncbi Dietary fats, fatty acids and insulin resistance: short review of a multifaceted connection
    Marianne Haag
    Department of Physiology, University of Pretoria, Pretoria, South Africa
    Med Sci Monit 11:RA359-67. 2005
    ..Greater understanding of the role played by dietary fat and plasma fatty acids in pathogenesis of insulin resistance, will allow for more timely prevention and improved treatment in the future...
  97. ncbi Estrogens protect against high-fat diet-induced insulin resistance and glucose intolerance in mice
    Elodie Riant
    Institut National de la Santé et de la Recherche Médicale Unité 858, Institut de Medecine Moleculaire de Rangueil, Boite Postale 84225, 31432 Toulouse Cedex 4, France
    Endocrinology 150:2109-17. 2009
    ..In conclusion, the regulation of the ERalpha pathway could represent an effective strategy to reduce the impact of high-fat diet-induced type 2 diabetes...
  98. ncbi The nutrition transition in Egypt: obesity, undernutrition and the food consumption context
    Osman M Galal
    School of Public Health, University of California, Los Angeles 90095, USA
    Public Health Nutr 5:141-8. 2002
    ..To describe changing food consumption patterns in Egypt over the last several decades, current levels of overweight and obesity, and current data on obesity-related morbidity...
  99. ncbi The role of high-fat diets and physical activity in the regulation of body weight
    P Schrauwen
    Department of Human Biology, Maastricht University, The Netherlands
    Br J Nutr 84:417-27. 2000
    ..In conclusion, the increased intake of dietary fat and a decreasing physical activity level are the most important environmental factors explaining the increased prevalence of obesity in westernized societies...
  100. pmc Food groups, oils and butter, and cancer of the oral cavity and pharynx
    S Franceschi
    Servizio di Epidemiologia, Centro di Riferimento Oncologico, Aviano PN, Italy
    Br J Cancer 80:614-20. 1999
    ..Thus, frequent consumption of vegetables, citrus fruit, fish and vegetable oils were the major features of a low-risk diet for cancer of the oral cavity and pharynx...
  101. ncbi Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids
    J Todoric
    Clinical Division of Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Wahringer Gurtel 18 20, 1090, Vienna, Austria
    Diabetologia 49:2109-19. 2006
    ..In this study, we investigated how PUFA affect white adipose tissue inflammation and gene expression in obese diabetic animals...

Research Grants63

  1. Functions of the Human OST-alpha and OST-beta Proteins
    Patricia M Hinkle; Fiscal Year: 2013
    ..Because the enterohepatic circulation of bile acids is essential for processes such as intestinal absorption of dietary fats and vitamins, cholesterol homeostasis, bile flow, and biliary lipid secretion, these data suggest that Ost?-Ost?..
  2. Attenuation of androgen deprivation therapy-induced metabolic syndrome by diet
    Oleg Varlamov; Fiscal Year: 2013
    ..goal of the present proposal is to further our understanding of the ADT-related MS and establish the effects of dietary fats on the progression and reversal of MS in non-human primates (NHP;rhesus macaques)...
  3. CNS PPAR gamma and energy homeostasis
    HEIDI E KOCALIS; Fiscal Year: 2011
    ..Such a finding would have far reaching implications, first, supporting the idea that dietary fats, via their action on PPARy have physiological effects that extend beyond their basic nutritional profile...
  4. Mechanisms of Renal Lipotoxicity and Injury in Obesity and Diabetes
    Jesus H Dominguez; Fiscal Year: 2013
    ..Current dietary fats contain a large proportion of proinflammatory saturated fatty acids (PSFA), and proinflammatory lipid peroxides,..
  5. MAL2 regulation of hepatic protein trafficking: mechanisms and binding partners
    Pamela L Tuma; Fiscal Year: 2012
    ..surface faces the bile (the external environment), the complex molecular "soap" that helps in absorption of dietary fats and waste removal...
  6. Dietary Fat Composition, Plasma Lipids, and Cognitive Decline
    OLIVIA IFEOMA OKEREKE; Fiscal Year: 2011
    ..Furthermore, in order to address the candidate's hypotheses regarding mechanistic links between dietary fats and cognitive change, she proposes new collection of two innovative markers of oxidative stress among a subset ..
  7. Comparative-Effectiveness of Population Strategies to Improve Diet and Reduce CVD
    Dariush Mozaffarian; Fiscal Year: 2013
    ..We will primarily focus on effect sizes for fruits and vegetables, dietary fats, salt, an SSBs...
  8. Genetic Discovery of New Regulators of Fatty Acid Synthesis
    Daniel E Gottschling; Fiscal Year: 2012
    ..Fatty acids are obtained directly from absorption of dietary fats, or from conversion of digested nutrients to fatty acids via de novo synthesis...
  9. Metabolic Determinants of Cardiac Bioactive Sphingolipids in Lipid Overload
    Sarah Brice Russo; Fiscal Year: 2013
    ..used for sphingolipid synthesis, as well as how sphingolipid levels and production are regulated by different dietary fats. Ceramide, a key sphingolipid signaling molecule, has been implicated in the development of diabetic ..
  10. Damaging Effects of a Saturated Fat/Cholesterol Diet toe the Brain
    LINNEA RUTH FREEMAN; Fiscal Year: 2010
    ..While there are many possible contributors to cognitive decline, this study focuses on and explores the role of dietary fats, particularly on hippocampal morphology...
  11. Circulating Dietary &Metabolic Fatty Acids, Major CVD Outcomes, &Healthy Aging
    Dariush Mozaffarian; Fiscal Year: 2013
    ..Historically, FA research has focused on broad categories of dietary fats, e.g...
  12. Modulation of neural function in energy failure
    JUAN MANUEL PASCUAL; Fiscal Year: 2013
    ..The proposal also includes the therapeutic consideration that even-carbon ketones, generated from common dietary fats or a ketogenic diet, can fuel the TCA cycle and ameliorate seizures in G1D, but are not anaplerotic...
  13. (PQA3) The gut-brain axis: a novel target for treating behavioral alterations in
    Dana M Small; Fiscal Year: 2013
    ..In both rodents and humans, excessive intake of dietary fats leads to dysregulated neuronal function in dorsal striatum...
  14. Dietary fat effects on gut microbes, host immune state and experimental colitis
    Eugene B Chang; Fiscal Year: 2013
    ..Two hypotheses will be tested: (1) that certain dietary fats which that are well represented in "Western diets" ar capable of either precipitating or preventing/..
  15. PROTEASE INHIBITOR-INDUCED HYPERLIPIDEMIA IN AIDS
    Virgil Brown; Fiscal Year: 2004
    ..LRP is responsible for the hepatic uptake of intestinal lipoproteins transporting dietary fats and fat- soluble vitamins such as vitamin A...
  16. Regulation of syndecan 1 in by n-3 PUFA
    IRIS EDWARDS; Fiscal Year: 2009
    ..Studies will use LDL obtained from African green monkeys fed dietary fats proposed to have opposite effects in human breast cancer: n-6 PUFA (tumor promoting) and n-3 PUFA (tumor ..
  17. PANCREATIC LIPASES AND COLIPASE IN LIPOLYSIS AND OBESITY
    Mark Lowe; Fiscal Year: 2007
    ..In Specific Aim 1 we will measure the absorption of a variety of dietary fats in CEL and PLRP2 deficient mice, which are already available. We will monitor growth and fecal fat absorption...
  18. NITRIC OXIDE AND GASTROINTESTINAL OXIDATIVE INJURY
    Walee Chamulitrat; Fiscal Year: 1999
    ..These test compounds are relevant since lipid hydroperoxides are present in dietary fats, and TNBS is a chemical irritant commonly used to produce inflammatory responses in chronic colitis models...
  19. STRUCTURE-FUNCTION ANALYSIS OF COLIPASE AND LIPASE
    Mark Lowe; Fiscal Year: 2005
    ..b>Dietary fats provide a major source of energy, essential fatty acids, a vehicle for fat-soluble vitamins, and components of ..
  20. ALTERED MEMBRANE PHOSPHOLIPIDS AND CARDIAC FUNCTION
    DIANE REIBEL; Fiscal Year: 1990
    ..This is surprising in view of the fact that modification of dietary fats can profoundly alter the lipid composition of cellular membranes in the myocardium...
  21. Diet and Risk of Ovarian Cancer
    Ellen Chang; Fiscal Year: 2005
    ..to evaluate the relationship between ovarian cancer risk and (a) phytoestrogens and isothiocyanates, (b) eggs, dietary fats and dairy products, (c) alcohol, and (d) dietary patterns...
  22. Long-Term Dietary Risk Factor Assessment and Incident AD
    MARTHA MORRIS; Fiscal Year: 2009
    ..to investigate hypotheses on the associations of long-term dietary intake of a number of micro nutrients and dietary fats with incident Alzheimer's disease and cognitive decline in an existing biracial population study, the ..
  23. Serum fatty acids and ischemic stroke in women
    Ka He; Fiscal Year: 2009
    ..coronary heart disease (CHD) and ischemic stroke share some major risk factors, limited epidemiological data on dietary fats and vascular disease risk indicate that fatty acids have different associations with ischemic stroke than with ..
  24. Conference on Lipids in Immune Function
    Robert Katz; Fiscal Year: 2002
    ..at the 5th Congress of the International Society for the Study of Fatty Acids and Lipids, at the ISSFAL 2002 "Dietary Fats and Health," May 7-11, 2002, Montreal, Canada. This I-day session will be held on May 10, 2002...
  25. MOLECULAR ANALYSIS OF THE MAMMALIAN FATTY ACID TRANSPORT
    DAVID BERNLOHR; Fiscal Year: 1999
    ..b>Dietary fats (triglycerides) are emulsified and hydrolyzed in the gut, packaged by the small intestine and secreted as ..
  26. Pregnancy Estrogens, Diet, and Breast Cancer Risk
    Leena Hilakivi Clarke; Fiscal Year: 2005
    ..Diet, particularly dietary fats, may affect pregnancy estrogen levels and later breast cancer risk...
  27. Exploiting Nutrition on Delay Cataract
    Allen Taylor; Fiscal Year: 2006
    ..lower in persons who a) consume higher levels of specific fats (monounsaturated, polyunsaturated, and saturated dietary fats, n-3 fatty acids, etc...
  28. RENAL EFFECTS OF DIETARY FAT IN EXPERIMENTAL DIABETES
    JOY LOGAN; Fiscal Year: 1992
    ..Experiments are proposed to examine the effects of two dietary fats, eicosapentaenoic acid and linoleic acid, on renal fatty acid metabolism...
  29. MAMMARY CARCINOGENESIS: DIETARY FATS AND ANTIOXIDANTS
    Mary King; Fiscal Year: 1980
    ....
  30. Dietary Cancer Prevention in DNA Repair Deficient Mice
    Laura Niedernhofer; Fiscal Year: 2007
    ..The results from these experiments will indicate if dietary fats increase the amount of endogenous DNA damage and if this damage can promote tumorigenesis...
  31. NONINVASIVE MEASUREMENT OF ENERGY EXPENDITURE IN HUMANS
    Dale Schoeller; Fiscal Year: 2007
    ..We have preliminarydata that suggests that the mechanism involves increased oxidation of dietary fats consumed after exercise...
  32. REGULATION OF BOVINE MAMMARY DEVELOPMENT BY DIETARY FAT
    THOMAS MCFADDEN; Fiscal Year: 1992
    DESCRIPTION (Investigator's Abstract): Dietary fats are known to profoundly influence a broad array of physiological functions...
  33. PEROXY RADICAL MEDIATED DNA DAMAGE
    John Termini; Fiscal Year: 2002
    ..b>Dietary fats directly influence the unsaturated lipid content of cellular membranes...
  34. MODULATION OF SKELETAL INTERGRITY--DIETARY FAT WITH AGE
    REBECCA CORWIN; Fiscal Year: 1999
    ..Americans, the increasing size of the aged population, and the high prevalence of osteoporosis in the United States, there is an urgent need to examine the impact that dietary fats have on skeletal integrity with age.
  35. Androgen Pathway Factors and Prostate Cancer
    John Witte; Fiscal Year: 2005
    ..Specific Aim 3. Our third aim is to synthesize the information on candidate genes and dietary fats studied here by looking at their joint and interactive effects on prostate cancer risk...
  36. CONTROL OF LP(A) IN VITRO
    Edward Rubin; Fiscal Year: 2000
    ..The applicant will examine the mechanism by which sex hormones and dietary fats may influence expression of Lp(a), principally by studying their interactions with polymorphic flanking ..
  37. NUTRITIONAL FACTORS IN RETINAL FUNCTION
    KENNETH HAYES; Fiscal Year: 1991
    ..of LPs from infants (cord blood) and adults (normo and hyperlipemic, patients with RP) or animals fed different dietary fats (saturated vs PUFA), cholesterol, and with or without vitamin E deficiency...
  38. Mechanisms for differential effects of dietary fatty acids on metabolism
    CRAIG LAWRENCE KIEN; Fiscal Year: 2010
    ..important new information regarding how mitochondrial malfunction, modified by dietary FA, plays a central role in the development of obesity, the metabolic syndrome, type 2 diabetes, and both heritable and age-related metabolic diseases ..
  39. DIFFERENTIAL METABOLISM OF DIETARY FATTY ACIDS
    CRAIG KIEN; Fiscal Year: 2003
    ..In specific aim 4, the PI will measure the thermic effect of feeding during both the solid food and formula diet periods. The PI hypothesizes that the high OA feeding will be associated with a higher thermic effect of feeding. ..
  40. Colonic Bacterial Synthesis of Butyric Acid
    CRAIG KIEN; Fiscal Year: 2004
    ....
  41. Fatty Acids and Cardiovascular Health
    Dariush Mozaffarian; Fiscal Year: 2007
    ..End of Abstract) [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  42. Growth Factors and Colon Cancer
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2006
    ..This study builds on a unique existing resource to study genetic and environmental associations with colorectal cancer. It will provide insight into colon cancer etiology and therefore avenues to disease prevention. ..
  43. Brain LC-PUFAs and Maternal Mental Health
    Beth Levant; Fiscal Year: 2006
    ..These findings will also suggest novel treatments for such illnesses when they occur. ..
  44. HEDONICS AND DIETARY INTAKE OF FAT
    Richard Mattes; Fiscal Year: 2008
    ..This will be explored through stable isotope tracer studies for Aim 3. The proposed work will hold important public health, clinical, commercial and basic biological implications. [unreadable] [unreadable]..
  45. ETHANOL EFFECTS ON BONE FORMATION IN PREGNANCY
    Martin Ronis; Fiscal Year: 2006
    ..The role of CYP2E1 and free radicals in the skeletal toxicity of ethanol during these periods will also be studied. ..
  46. CARDIAC ENERGY METABOLISM IN HEART FAILURE
    William Stanley; Fiscal Year: 2005
    ..The meeting is organized by the Society for Heart and Vascular Metabolism, a not-for-profit educational corporation with an established record for organizing successful meetings related to metabolism and heart disease. ..
  47. Genetic Polymorphisms Benign Prostatic Hyperplasia
    ROSEBUD ROBERTS; Fiscal Year: 2004
    ..This community-based cohort study should provide insights that should improve our understanding of the genetic control of hormonal mechanisms in the pathogenesis of BPH. ..
  48. FOUR-CORNERS BREAST AND ENDOMETRIAL CANCER STUDY
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2003
    ..C-peptide, glycosylated hemoglobin, IGF-1, and IGFBP3 will be evaluated with respect to breast and endometrial cancer in a subset of women. ..
  49. Food Rheology and Feeding in Lean and Obese Humans
    Richard Mattes; Fiscal Year: 2007
    ..abstract_text> ..
  50. DIET AND SOMATIC MUTATIONS IN COLON CANCER
    MARTHA OR MARTY SLATTERY; Fiscal Year: 2007
    ..e. p53, K-ras, and microsatellite instability). Differences in colon and rectal tumors will be compared. Additionally data from rectal tumors will be combined with that from colon tumors to define disease pathways. ..
  51. Vascular and Inflammatory Predictors of MCI Risk and Progression
    ROSEBUD ROBERTS; Fiscal Year: 2008
    ..The K01 award will culminate in an R01 application that will pave the way for the candidate to become an independent investigator in MCI and AD research. [unreadable] [unreadable] [unreadable]..
  52. Predictors of Nephropathy in Type 2 Diabetes
    Julie Lin; Fiscal Year: 2008
    ..D., Ph.D., a leading investigator in the field of nutritional epidemiology. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in renal research. ..
  53. Biomarkers in the progression of nephropathy in type 2DM
    Julie Lin; Fiscal Year: 2008
    ..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. [unreadable] [unreadable]..
  54. Cysteine, Related Gene Variants and Breast Cancer Risk
    Walter C Willett; Fiscal Year: 2010
    ....
  55. Metabolic Signaling in the Cardiovascular System
    William Stanley; Fiscal Year: 2008
    ..End of Abstract) [unreadable] [unreadable] [unreadable]..
  56. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  57. Hemodynamic forces regulate BMPs in coronary arteries
    Zoltan Ungvari; Fiscal Year: 2009
    ..abstract_text> ..