lipids

Summary

Summary: A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi A simple method for the isolation and purification of total lipides from animal tissues
    J Folch
    J Biol Chem 226:497-509. 1957
  2. ncbi A rapid method of total lipid extraction and purification
    E G BLIGH
    Can J Biochem Physiol 37:911-7. 1959
  3. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
  4. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
  5. pmc Membrane lipids: where they are and how they behave
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 9:112-24. 2008
  6. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
  7. ncbi The lipid droplet is an important organelle for hepatitis C virus production
    Yusuke Miyanari
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Nat Cell Biol 9:1089-97. 2007
  8. pmc Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types
    Jeffery B Klauda
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA
    J Phys Chem B 114:7830-43. 2010
  9. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
  10. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009

Detail Information

Publications302 found, 100 shown here

  1. ncbi A simple method for the isolation and purification of total lipides from animal tissues
    J Folch
    J Biol Chem 226:497-509. 1957
  2. ncbi A rapid method of total lipid extraction and purification
    E G BLIGH
    Can J Biochem Physiol 37:911-7. 1959
  3. pmc Biological, clinical and population relevance of 95 loci for blood lipids
    Tanya M Teslovich
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nature 466:707-13. 2010
    ..We screened the genome for common variants associated with plasma lipids in >100,000 individuals of European ancestry...
  4. ncbi The metabolic syndrome
    Robert H Eckel
    Division of Endocrinology, Metabolism and Diabetes, University of Colorado at Denver and Health Sciences Center, PO Box 6511, MS 8106, Aurora, CO 80045, USA
    Lancet 365:1415-28. 2005
    ..The fundamental approach is weight reduction and increased physical activity; however, drug treatment could be appropriate for diabetes and cardiovascular disease risk reduction...
  5. pmc Membrane lipids: where they are and how they behave
    Gerrit van Meer
    Bijvoet Center and Institute of Biomembranes, Utrecht University, 3584 CH Utrecht, The Netherlands
    Nat Rev Mol Cell Biol 9:112-24. 2008
    ..anabolic and catabolic enzymes, translocases and transporters, plus the intrinsic physical phase behaviour of lipids and their interactions with membrane proteins, to create the unique compositions and multiple functionalities of ..
  6. pmc Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans
    Kimber L Stanhope
    Department of Molecular Biosciences, UCD, Davis, California 95616, USA
    J Clin Invest 119:1322-34. 2009
    ..These data suggest that dietary fructose specifically increases DNL, promotes dyslipidemia, decreases insulin sensitivity, and increases visceral adiposity in overweight/obese adults...
  7. ncbi The lipid droplet is an important organelle for hepatitis C virus production
    Yusuke Miyanari
    Department of Viral Oncology, Institute for Virus Research, Kyoto University, Kyoto 606 8507, Japan
    Nat Cell Biol 9:1089-97. 2007
    The lipid droplet (LD) is an organelle that is used for the storage of neutral lipids. It dynamically moves through the cytoplasm, interacting with other organelles, including the endoplasmic reticulum (ER)...
  8. pmc Update of the CHARMM all-atom additive force field for lipids: validation on six lipid types
    Jeffery B Klauda
    Department of Chemical and Biomolecular Engineering, University of Maryland, College Park, Maryland 20742, USA
    J Phys Chem B 114:7830-43. 2010
    ..These changes were tested with simulations of pure bilayers at high hydration of the following six lipids: DPPC, 1,2-dimyristoyl-sn-phosphatidylcholine (DMPC), 1,2-dilauroyl-sn-phosphatidylcholine (DLPC), 1-palmitoyl-2-..
  9. pmc Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts
    Yurii S Aulchenko
    1 Department of Epidemiology and Biostatistics, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands 2 These authors contributed equally to this work
    Nat Genet 41:47-55. 2009
    Recent genome-wide association (GWA) studies of lipids have been conducted in samples ascertained for other phenotypes, particularly diabetes...
  10. pmc Lipid droplets finally get a little R-E-S-P-E-C-T
    Robert V Farese
    Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA
    Cell 139:855-60. 2009
    ..In light of this newfound respect, we discuss emerging views on lipid droplet biology and speculate on the major advances to come...
  11. ncbi Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling
    Joanna C Betts
    Respiratory Pathogens, GlaxoSmithKline, Stevenage, Herts, UK
    Mol Microbiol 43:717-31. 2002
    ..Thus, we have generated a model with which we can search for agents active against persistent M. tuberculosis and revealed a number of potential targets expressed under these conditions...
  12. pmc ExoCarta 2012: database of exosomal proteins, RNA and lipids
    Suresh Mathivanan
    Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, Victoria 3086, Australia
    Nucleic Acids Res 40:D1241-4. 2012
    ..ExoCarta (//www.exocarta.org) is a manually curated database of exosomal proteins, RNA and lipids. The database catalogs information from both published and unpublished exosomal studies...
  13. ncbi European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by r
    Ian Graham
    Department of Cardiology, Adelaide and Meath Hospital, Dublin, Ireland
    Eur Heart J 28:2375-414. 2007
  14. pmc Lipid-induced insulin resistance: unravelling the mechanism
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Lancet 375:2267-77. 2010
    ..More than 40 years ago, Randle and colleagues postulated that lipids impaired insulin-stimulated glucose use by muscles through inhibition of glycolysis at key points...
  15. pmc Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci
    Folkert W Asselbergs
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hum Genet 91:823-38. 2012
    ..The explained phenotypic variance from this approach was comparable to that from a meta-analysis of GWAS data, suggesting that a focused genotyping approach can further increase the understanding of heritability of plasma lipids.
  16. ncbi European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by represent
    Ian Graham
    Department of Cardiology, The Adelaide and Meath Hospital, Tallaght, Dublin, Ireland
    Eur J Cardiovasc Prev Rehabil 14:S1-113. 2007
  17. pmc The role of lipid droplets in metabolic disease in rodents and humans
    Andrew S Greenberg
    Obesity and Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, Massachusetts 02111, USA
    J Clin Invest 121:2102-10. 2011
    Lipid droplets (LDs) are intracellular organelles that store neutral lipids within cells...
  18. ncbi Getting to the fat of the matter: models, methods and assumptions for dealing with lipids in stable isotope analyses
    David M Post
    Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520 8105, USA
    Oecologia 152:179-89. 2007
    Within an organism, lipids are depleted in (13)C relative to proteins and carbohydrates (more negative delta(13)C), and variation in lipid content among organisms or among tissue types has the potential to introduce considerable bias into ..
  19. ncbi Newly identified loci that influence lipid concentrations and risk of coronary artery disease
    Cristen J Willer
    Center for Statistical Genetics, Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan 48109, USA
    Nat Genet 40:161-9. 2008
    ..Notably, the 11 independent variants associated with increased LDL cholesterol concentrations in our study also showed increased frequency in a sample of coronary artery disease cases versus controls...
  20. ncbi Lipid-induced insulin resistance in human muscle is associated with changes in diacylglycerol, protein kinase C, and IkappaB-alpha
    Samar I Itani
    Diabetes Unit, Section of Endocrinology, Department of Medicine, Boston University Medical Center, Boston, MA, USA
    Diabetes 51:2005-11. 2002
    ..Whether acute FFA-induced insulin resistance in human skeletal muscle is caused by the activation of these specific PKC isoforms and the IKK-beta/IkappaB/NFkappaB pathway remains to be established...
  21. pmc Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors
    E B Rimm
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    BMJ 319:1523-8. 1999
    ..To summarise quantitatively the association between moderate alcohol intake and biological markers of risk of coronary heart disease and to predict how these changes would lower the risk...
  22. ncbi Proteomic analysis of proteins associated with lipid droplets of basal and lipolytically stimulated 3T3-L1 adipocytes
    Dawn L Brasaemle
    Department of Nutritional Sciences, Rutgers, The State University of New Jersey, New Brunswick, New Jersey 08901, USA
    J Biol Chem 279:46835-42. 2004
    ....
  23. pmc Fish oil supplementation alters the plasma lipidomic profile and increases long-chain PUFAs of phospholipids and triglycerides in healthy subjects
    Inger Ottestad
    Department of Health, Nutrition and Management, Faculty of Health Sciences, Oslo and Akershus University College of Applied Sciences, Oslo, Norway
    PLoS ONE 7:e42550. 2012
    ..The aim of this study was to investigate the effect of fish oil supplementation on the plasma lipidomic profile in healthy subjects...
  24. ncbi Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment
    Stephen B Long
    Howard Hughes Medical Institute, Laboratory of Molecular Neurobiology and Biophysics, Rockefeller University, 1230 York Avenue, New York, New York 10065, USA
    Nature 450:376-82. 2007
    ..1 to Kv1.2. Crystallized in complex with lipids, the complete structure at 2...
  25. pmc Lipid droplets and cellular lipid metabolism
    Tobias C Walther
    Department of Cell Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Biochem 81:687-714. 2012
    ..Their hydrophobic core of neutral lipids stores metabolic energy and membrane components, making LDs hubs for lipid metabolism...
  26. pmc PAT proteins, an ancient family of lipid droplet proteins that regulate cellular lipid stores
    Perry E Bickel
    Center for Diabetes and Obesity Research, Brown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, Texas, USA
    Biochim Biophys Acta 1791:419-40. 2009
    ..In this review, we discuss how the PAT proteins regulate cellular lipid metabolism both in mammals and in model organisms...
  27. ncbi Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women
    Sandeep Bansal
    Donald W Reynolds Center for Cardiovascular Research, Brigham and Women s Hospital, Boston, MA 02215, USA
    JAMA 298:309-16. 2007
    ..Although triglyceride levels are typically obtained in the fasting state, postprandial hypertriglyceridemia may play an important role in atherosclerosis...
  28. ncbi Lipid signalling in disease
    Matthias P Wymann
    Institute of Biochemistry and Genetics, Department of Biomedicine, University of Basel, Mattenstrasse 28, CH 4058 Basel, Switzerland
    Nat Rev Mol Cell Biol 9:162-76. 2008
    Signalling lipids such as eicosanoids, phosphoinositides, sphingolipids and fatty acids control important cellular processes, including cell proliferation, apoptosis, metabolism and migration...
  29. ncbi Solid lipid nanoparticles: production, characterization and applications
    W Mehnert
    Institute of Pharmacy, Department of Pharmaceutical Technology, Free University of Berlin, Kelchstr 31, D 12169, Berlin, Germany
    Adv Drug Deliv Rev 47:165-96. 2001
    ..The use of several analytical techniques is a necessity. Alternative structures and dynamic phenomena on the molecular level have to be considered. Aspects of SLN administration and the in vivo fate of the carrier are discussed...
  30. pmc Lipid profiling identifies a triacylglycerol signature of insulin resistance and improves diabetes prediction in humans
    Eugene P Rhee
    Nephrology Division, Massachusetts General Hospital, Boston, Massachusetts 02129, USA
    J Clin Invest 121:1402-11. 2011
    Dyslipidemia is an independent risk factor for type 2 diabetes, although exactly which of the many plasma lipids contribute to this remains unclear...
  31. ncbi Plasma adiponectin levels and risk of myocardial infarction in men
    Tobias Pischon
    Department of Nutrition, Harvard School of Public Health, Channing Laboratory, Boston, Mass 02115, USA
    JAMA 291:1730-7. 2004
    ..Adiponectin, a recently discovered adipocyte-derived peptide, is involved in the regulation of insulin sensitivity and lipid oxidation and, purportedly, in the development of atherosclerosis and coronary heart disease in humans...
  32. ncbi Lipid mediator class switching during acute inflammation: signals in resolution
    B D Levy
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Nat Immunol 2:612-9. 2001
    ..These results indicate that first-phase eicosanoids promote a shift to anti-inflammatory lipids: functionally distinct lipid-mediator profiles switch during acute exudate formation to "reprogram" the ..
  33. pmc Linking lipids to Alzheimer's disease: cholesterol and beyond
    Gilbert Di Paolo
    Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer s Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, New York, New York 10032, USA
    Nat Rev Neurosci 12:284-96. 2011
    ..attention has been given to the link between cholesterol and AD pathogenesis, growing evidence suggests that other lipids, such as phosphoinositides and phosphatidic acid, have an important role...
  34. ncbi Lipotoxicity: when tissues overeat
    Jean E Schaffer
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Lipidol 14:281-7. 2003
    ..Physiologic responses to lipid overload and therapeutic approaches to decreasing lipid accumulation will be discussed, as they add to our understanding of important pathophysiologic mechanisms...
  35. pmc Cardiometabolic risk variables in overweight and obese children: a worldwide comparison
    Mariska van Vliet
    Department of Pediatrics, Slotervaart Hospital, Louwesweg 6, 1066 EC, Amsterdam, The Netherlands
    Cardiovasc Diabetol 10:106. 2011
    ..The results of our review present a fair estimation of the true differences between cardiometabolic risk profiles among pediatric cohorts worldwide, based on available literature...
  36. ncbi Phytoplankton in the ocean use non-phosphorus lipids in response to phosphorus scarcity
    Benjamin A S van Mooy
    Department of Marine Chemistry and Geochemistry, Woods Hole Oceanographic Institution, Woods Hole, Massachusetts 02543, USA
    Nature 458:69-72. 2009
    ..where phosphate is scarce, reduce their cellular phosphorus requirements by substituting non-phosphorus membrane lipids for phospholipids...
  37. pmc The lipodystrophy protein seipin is found at endoplasmic reticulum lipid droplet junctions and is important for droplet morphology
    Kimberly M Szymanski
    Department of Pharmacology, University of Texas Southwestern Medical School, Dallas, TX 75390, USA
    Proc Natl Acad Sci U S A 104:20890-5. 2007
    ..The genes identified in our screen should be of value in understanding the pathway of lipid droplet biogenesis and maintenance and the cause of some lipodystrophies...
  38. ncbi Absence of monocyte chemoattractant protein-1 reduces atherosclerosis in low density lipoprotein receptor-deficient mice
    L Gu
    Department of Adult Oncology, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Mol Cell 2:275-81. 1998
    ..Thus, MCP-1 plays a unique and crucial role in the initiation of atherosclerosis and may provide a new therapeutic target in this disorder...
  39. pmc Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry
    Christer S Ejsing
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Proc Natl Acad Sci U S A 106:2136-41. 2009
    ..This work serves as a resource for molecular characterization of eukaryotic lipidomes, and establishes shotgun lipidomics as a powerful platform for complementing biochemical studies and other systems-level approaches...
  40. pmc TIP47 functions in the biogenesis of lipid droplets
    Anna V Bulankina
    Institute for Biochemistry II, University of Gottingen, 37073 Gottingen, Germany
    J Cell Biol 185:641-55. 2009
    ..Suppression of TIP47 blocked LD maturation and decreased the incorporation of triacylglycerol into LDs. We conclude that TIP47 functions in the biogenesis of LDs...
  41. pmc Chemical vectors for gene delivery: a current review on polymers, peptides and lipids containing histidine or imidazole as nucleic acids carriers
    Patrick Midoux
    Centre de Biophysique Moléculaire CNRS UPR 4301 affiliated to the University of Orléans and Inserm, rue Charles Sadron, F 45071 Orleans cedex 2, France
    Br J Pharmacol 157:166-78. 2009
    ..Here, we present a current report on a particular class of carriers including the polymers, peptides and lipids, which is based on the exploitation of the imidazole ring as an endosome destabilization device to favour the ..
  42. pmc Lipidomics reveals a remarkable diversity of lipids in human plasma
    Oswald Quehenberger
    Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093 0601, USA
    J Lipid Res 51:3299-305. 2010
    ..the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids. Partial lipid analysis is now a regular part of every patient's blood test and physicians readily and regularly ..
  43. ncbi Role of intramyocelluar lipids in human health
    Paul M Coen
    Department of Health and Physical Activity, University of Pittsburgh, Trees Hall Rm 134D, Allequippa Street and Darragh Street, Pittsburgh, PA 15260, USA
    Trends Endocrinol Metab 23:391-8. 2012
    ..Quantitative lipidomics and proteomics of targeted subcellular organelles will help to better define the mechanisms underlying pathological IMCL accumulation and IR...
  44. ncbi Effects of the association of aging and obesity on lipids, lipoproteins and oxidative stress biomarkers: a comparison of older with young men
    N Karaouzene
    Department of Molecular and Cellular Biology, Faculty of Sciences, University Abou Bekr Belkaid, Tlemcen, Algeria
    Nutr Metab Cardiovasc Dis 21:792-9. 2011
    In this study, plasma lipids, lipoproteins and markers of oxidant/antioxidant status were investigated in young (n = 45) and older (n = 40) obese men and compared to those in young (n = 65) and older (n = 55) normal weight controls...
  45. ncbi Hepatitis C virus core protein induces lipid droplet redistribution in a microtubule- and dynein-dependent manner
    Steeve Boulant
    MRC Virology Unit, Institute of Virology, Church Street, Glasgow G11 5JR, UK
    Traffic 9:1268-82. 2008
    ..We propose that the presence of core on LDs favours their movement towards the nucleus, possibly to increase the probability of interaction between sites of HCV RNA replication and virion assembly...
  46. ncbi Toxicity of cationic lipids and cationic polymers in gene delivery
    Hongtao Lv
    Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China
    J Control Release 114:100-9. 2006
    ..Appropriate gene vectors can be crucial for gene transfer. Cationic lipids and polymers, the most important non-viral vectors, have many advantages over viral ones as non-immunogenic, easy ..
  47. ncbi Lipidomics: coming to grips with lipid diversity
    Andrej Shevchenko
    Max Planck Institute of Molecular Cell Biology and Genetics, 01307 Dresden, Germany
    Nat Rev Mol Cell Biol 11:593-8. 2010
    Although lipids are biomolecules with seemingly simple chemical structures, the molecular composition of the cellular lipidome is complex and, currently, poorly understood...
  48. ncbi Thematic review series: skin lipids. The role of epidermal lipids in cutaneous permeability barrier homeostasis
    Kenneth R Feingold
    Metabolism Section, Medical Service, Department of Veterans Affairs Medical Center, University of California San Francisco, San Francisco, CA 94121, USA
    J Lipid Res 48:2531-46. 2007
    ..The lipids that constitute the extracellular matrix have a unique composition and are 50% ceramides, 25% cholesterol, and 15% ..
  49. pmc Triglyceride-mediated pathways and coronary disease: collaborative analysis of 101 studies
    Nadeem Sarwar
    Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Wort s Causeway, Cambridge CB1 8RN, UK
    Lancet 375:1634-9. 2010
    ..Whether triglyceride-mediated pathways are causally relevant to coronary heart disease is uncertain. We studied a genetic variant that regulates triglyceride concentration to help judge likelihood of causality...
  50. pmc Lipid droplets: a classic organelle with new outfits
    Toyoshi Fujimoto
    Department of Anatomy and Molecular Cell Biology, Graduate School of Medicine, Nagoya University, 65 Tsurumai, Showa, Nagoya, 466 8550, Japan
    Histochem Cell Biol 130:263-79. 2008
    Lipid droplets are depots of neutral lipids that exist virtually in any kind of cell...
  51. ncbi Prevalence of metabolic syndrome in an urban population: Tehran Lipid and Glucose Study
    Fereidoun Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, P O Box 4763, Tehran 19395, Iran
    Diabetes Res Clin Pract 61:29-37. 2003
    ..This report on the metabolic syndrome from Iran shows a high prevalence of this disorder. Efforts on promoting healthy diets, physical activity, and blood pressure control must be undertaken...
  52. ncbi Lipid droplets in lipogenesis and lipolysis
    Nicole A Ducharme
    Center for Diabetes and Obesity Research, Brown Foundation Institute of Molecular Medicine, 1825 Pressler Street, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA
    Endocrinology 149:942-9. 2008
    ..Future discovery likely will be driven by the exploitation of model organisms and by human genetic studies...
  53. ncbi Effects of protein, monounsaturated fat, and carbohydrate intake on blood pressure and serum lipids: results of the OmniHeart randomized trial
    Lawrence J Appel
    Welch Center for Prevention, Epidemiology and Clinical Research, Division of General Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205 2223, USA
    JAMA 294:2455-64. 2005
    ..Reduced intake of saturated fat is widely recommended for prevention of cardiovascular disease. The type of macronutrient that should replace saturated fat remains uncertain...
  54. pmc A role for lipid droplets in inter-membrane lipid traffic
    John K Zehmer
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA
    Proteomics 9:914-21. 2009
    All cells have the capacity to accumulate neutral lipids and package them into lipid droplets...
  55. ncbi Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    Mengwei Zang
    Vascular Biology Unit, Boston University Medical Center, 650 Albany St, X704, MA 02118, USA
    Diabetes 55:2180-91. 2006
    ..in the pathogenesis of hyperlipidemia in diabetes, 2) point to a novel mechanism of action of polyphenols to lower lipids by activating AMPK, and 3) emphasize a new therapeutic avenue to benefit hyperlipidemia and atherosclerosis ..
  56. pmc Update of the LIPID MAPS comprehensive classification system for lipids
    Eoin Fahy
    San Diego Supercomputer Center, Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093 0505, USA
    J Lipid Res 50:S9-14. 2009
    ..the sponsorship of the LIPID MAPS Consortium developed and established a "Comprehensive Classification System for Lipids" based on well-defined chemical and biochemical principles and using an ontology that is extensible, flexible, and ..
  57. ncbi Stratum corneum lipids, skin barrier function and filaggrin mutations in patients with atopic eczema
    J M Jungersted
    Department of Dermatology, Roskilde Hospital, University of Copenhagen, Roskilde, Denmark
    Allergy 65:911-8. 2010
    ..Until now, no studies have analysed stratum corneum (SC) lipids combined with skin barrier parameters in subjects of known FLG genotype.
  58. ncbi Rational design of cationic lipids for siRNA delivery
    Sean C Semple
    Tekmira Pharmaceuticals, Burnaby, British Columbia, Canada
    Nat Biotechnol 28:172-6. 2010
    We adopted a rational approach to design cationic lipids for use in formulations to deliver small interfering RNA (siRNA)...
  59. ncbi Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment
    Benjamin J Ansell
    Department of Medicine, David Geffen School of Medicine at UCLA, Los Angeles, Calif 90095 1679, USA
    Circulation 108:2751-6. 2003
    ..The inflammatory/antiinflammatory properties of HDL were compared with HDL cholesterol in 2 groups of patients and in age- and sex-matched control subjects...
  60. ncbi Lipids of mitochondria
    Susanne E Horvath
    Institute of Biochemistry, Graz University of Technology, Petersgasse 12 2, A 8010 Graz, Austria
    Prog Lipid Res 52:590-614. 2013
    ..membrane biochemistry is the mitochondrion whose functionality depends on a coordinated supply of proteins and lipids. Mitochondria are capable of synthesizing several lipids autonomously such as phosphatidylglycerol, cardiolipin ..
  61. ncbi A Mycobacterium marinum TesA mutant defective for major cell wall-associated lipids is highly attenuated in Dictyostelium discoideum and zebrafish embryos
    Laeticia Alibaud
    Laboratoire de Dynamique des Interactions Membranaires Normales et Pathologiques, Université de Montpellier II et I, CNRS UMR 5235, Case 107, Place Eugene Bataillon, 34095 Montpellier Cedex 05, France
    Mol Microbiol 80:919-34. 2011
    ..chromatography analyses indicated that the tesA::Tn mutant failed to produce two major cell wall-associated lipids. Mass spectrometry and nuclear magnetic resonance clearly established the nature of missing lipids as phthioglycol ..
  62. pmc Lipidomic analyses of Mycobacterium tuberculosis based on accurate mass measurements and the novel "Mtb LipidDB"
    Mark J Sartain
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    J Lipid Res 52:861-72. 2011
    The cellular envelope of Mycobacterium tuberculosis is highly distinctive and harbors a wealth of unique lipids possessing diverse structural and biological properties...
  63. pmc Consequences of motor copy number on the intracellular transport of kinesin-1-driven lipid droplets
    George T Shubeita
    Department of Developmental and Cell Biology, University of California Irvine, Irvine, CA 92697, USA
    Cell 135:1098-107. 2008
    ..Apparently, higher-order regulatory mechanisms rather than motor number per se dominate cargo transport in vivo...
  64. pmc MR-visible lipids and the tumor microenvironment
    E James Delikatny
    Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA
    NMR Biomed 24:592-611. 2011
    MR-visible lipids or mobile lipids are defined as lipids that are observable using proton MRS in cells and tissues...
  65. pmc Comparative plasma lipidome between human and cynomolgus monkey: are plasma polar lipids good biomarkers for diabetic monkeys?
    Guanghou Shui
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore
    PLoS ONE 6:e19731. 2011
    ..Information pertaining to other lipid species in monkey plasma, however, is lacking and requires comprehensive experimental analysis...
  66. ncbi [Predictive values of body mass index and waist circumference to risk factors of related diseases in Chinese adult population]
    Beifan Zhou
    Department of Epidemiology, Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100037, China
    Zhonghua Liu Xing Bing Xue Za Zhi 23:5-10. 2002
    ....
  67. ncbi Molecular circuits of resolution: formation and actions of resolvins and protectins
    Gerard L Bannenberg
    Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 174:4345-55. 2005
    ..These results characterize the first molecular resolution circuits and their major components activated by specific novel lipid mediators (i.e., resolvin E1 and 10,17S-docosatriene) to promote resolution...
  68. pmc Spatial mapping of lipids at cellular resolution in embryos of cotton
    Patrick J Horn
    Department of Biological Sciences, Center for Plant Lipid Research, University of North Texas, Denton, Texas 76203, USA
    Plant Cell 24:622-36. 2012
    ..These compositional analyses, although able to resolve hundreds of molecular species of lipids in single extracts, lose the original cellular context from which these lipids are derived...
  69. pmc Internalization of modified lipids by CD36 and SR-A leads to hepatic inflammation and lysosomal cholesterol storage in Kupffer cells
    Veerle Bieghs
    Department of Molecular Genetics, Electron Microscopy Unit of Molecular Cell Biology, and Pathology, Nutrition and Toxicology Research NUTRIM Institute of Maastricht, University of Maastricht, Maastricht, The Netherlands
    PLoS ONE 7:e34378. 2012
    ..We hypothesize that CD36 and MSR1 contribute independently to the onset of inflammation in NASH, by affecting intracellular cholesterol distribution inside Kupffer cells (KCs)...
  70. pmc The yeast lipin orthologue Pah1p is important for biogenesis of lipid droplets
    Oludotun Adeyo
    Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    J Cell Biol 192:1043-55. 2011
    ..This was accompanied by an accumulation of neutral lipids in the endoplasmic reticulum (ER)...
  71. ncbi Uncovering the intimate relationship between lipids, cholesterol and GPCR activation
    Joanne Oates
    Biomembrane Structure Unit, Department of Biochemistry, University of Oxford, Oxford OX1 3QU, UK
    Curr Opin Struct Biol 21:802-7. 2011
    ..In this review we highlight the latest research on GPCR-membrane interactions and some of the tools available for more detailed studies...
  72. pmc Maternal lipids as strong determinants of fetal environment and growth in pregnancies with gestational diabetes mellitus
    Ute M Schaefer-Graf
    Department of Obstetrics, Vivantes Medical Center Berlin Neukoelln, Berlin, Germany
    Diabetes Care 31:1858-63. 2008
    To determine the contribution of maternal glucose and lipids to intrauterine metabolic environment and fetal growth in pregnancies with gestational diabetes mellitus (GDM).
  73. ncbi Serum lipids and lipoproteins in Chinese men and women
    Wenying Yang
    Department of Endocrinology, China Japan Friendship Hospital, Beijing, China
    Circulation 125:2212-21. 2012
    Because of rapid change in lifestyle risk factors, cardiovascular disease has become the leading cause of death in China. We sought to estimate the national levels of serum lipids and lipoproteins among the Chinese adult population.
  74. pmc TRPV1 channels are intrinsically heat sensitive and negatively regulated by phosphoinositide lipids
    Erhu Cao
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Neuron 77:667-79. 2013
    ..Beyond TRPV1, these findings are relevant to understanding how membrane lipids modulate other "receptor-operated" TRP channels.
  75. pmc A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection
    Toni I Pollin
    Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Science 322:1702-5. 2008
    ..Subclinical atherosclerosis, as measured by coronary artery calcification, was less common in carriers than noncarriers, which suggests that lifelong deficiency of apoC-III has a cardioprotective effect...
  76. ncbi A high throughput Nile red method for quantitative measurement of neutral lipids in microalgae
    Wei Chen
    Department of Applied Biological Sciences, Arizona State University, Mesa, AZ 85212, USA
    J Microbiol Methods 77:41-7. 2009
    ..The Nile red fluorescence method has been successfully applied to the determination of lipids in certain microalgae, but has been unsuccessful in many others, particularly those with thick, rigid cell walls ..
  77. ncbi Cyanobacterial photosystem II at 2.9-A resolution and the role of quinones, lipids, channels and chloride
    Albert Guskov
    Institut fur Chemie und Biochemie Kristallographie, Freie Universitat Berlin, Takustrasse 6, D 14195 Berlin, Germany
    Nat Struct Mol Biol 16:334-42. 2009
    ..protein subunits and complete modeling of all 35 chlorophyll a molecules and 12 carotenoid molecules, 25 integral lipids and 1 chloride ion per monomer...
  78. ncbi The plasma lipidomic signature of nonalcoholic steatohepatitis
    Puneet Puri
    Division of Gastroenterology, Department of Internal Medicine, Virginia Commonwealth University Medical Center, Richmond, VA, USA
    Hepatology 50:1827-38. 2009
    ..A comprehensive analysis of plasma lipids and eicosanoid metabolites quantified by mass spectrometry was performed in NAFL (n = 25) and NASH (n = 50) ..
  79. ncbi Large-scale human metabolomics studies: a strategy for data (pre-) processing and validation
    Sabina Bijlsma
    Business Unit Analytical Sciences and Business Unit Physiological Sciences, TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Anal Chem 78:567-74. 2006
    ..Univariate plots of potential biomarkers were used to obtain insight in up- or downregulation. The strategy proposed proved to be applicable for dealing with large-scale human metabolomics studies...
  80. ncbi Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: a systematic review
    Ethan M Balk
    Tufts New England Medical Center Evidence based Practice Center, Institute for Clinical Research and Health Policy Studies, Tufts New England Medical Center, NEMC 63, Boston, MA 02111, USA
    Atherosclerosis 189:19-30. 2006
    ..Five studies of ALA were inconsistent in their effects on lipids, Hgb A(1c) or FBS...
  81. ncbi Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial
    James A de Lemos
    Donald W Reynolds Cardiovascular Clinical Research Center, The University of Texas Southwestern Medical Center, Dallas 75390 9047, USA
    JAMA 292:1307-16. 2004
    ..Limited data are available evaluating how the timing and intensity of statin therapy following an acute coronary syndrome (ACS) event affect clinical outcome...
  82. ncbi Lipidomics: new tools and applications
    Markus R Wenk
    National University of Singapore, Yong Loo Lin School of Medicine, Department of Biochemistry, Centre for Life Sciences, Singapore
    Cell 143:888-95. 2010
    Once viewed simply as a reservoir for carbon storage, lipids are no longer cast as bystanders in the drama of biological systems...
  83. pmc Demonstrated and inferred metabolism associated with cytosolic lipid droplets
    Joel M Goodman
    Department of Pharmacology University of Texas Southwestern Medical School Dallas TX 75390 9041, USA
    J Lipid Res 50:2148-56. 2009
    ....
  84. ncbi The role of root apoplastic transport barriers in salt tolerance of rice (Oryza sativa L.)
    Pannaga Krishnamurthy
    National Centre for Biological Sciences, TIFR, Bangalore 560065, India
    Planta 230:119-34. 2009
    ..Enhanced barriers were detected after several days of moderate stress. Overall, more extensive apoplastic barriers in roots correlated with reduced Na+ uptake and enhanced survival when challenged with high salinity...
  85. ncbi Live cell multicolor imaging of lipid droplets with a new dye, LD540
    Johanna Spandl
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstr 108, 01307 Dresden, Germany
    Traffic 10:1579-84. 2009
    ..Its improved specificity, brightness and photostability support live cell imaging, which was used to demonstrate by two-color imaging lipid droplet motility along microtubules...
  86. pmc Coatomer-dependent protein delivery to lipid droplets
    Krishnakant G Soni
    Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    J Cell Sci 122:1834-41. 2009
    Lipid droplets (LDs) are cytoplasmic organelles that store neutral lipids for use as an energy supply in times of nutrient deprivation and for membrane assembly...
  87. ncbi Comparison of demography, diet, lifestyle, and serum lipid levels between the Guangxi Bai Ku Yao and Han populations
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, People s Republic of China
    J Lipid Res 48:2673-81. 2007
    ..The differences in the lipid profiles between the two ethnic groups were associated with different dietary habits, lifestyle choices, and levels of physical activities...
  88. ncbi Sterol regulatory element-binding proteins (SREBPs): transcriptional regulators of lipid synthetic genes
    H Shimano
    Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tennodai, Tsukuba, Ibaraki 305 8575, Japan
    Prog Lipid Res 40:439-52. 2001
    ..Future studies will be focused on understanding molecular mechanisms sensing cellular sterol and energy states where SREBPs are deeply involved...
  89. pmc PPAR gamma, bioactive lipids, and cancer progression
    Gregory T Robbins
    Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine
    Front Biosci (Landmark Ed) 17:1816-34. 2012
    ..We predict that indicators of PPARgamma activity may also serve as predictive markers for tailoring treatments...
  90. pmc A novel informatics concept for high-throughput shotgun lipidomics based on the molecular fragmentation query language
    Ronny Herzog
    Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
    Genome Biol 12:R8. 2011
    ....
  91. pmc Interactions between lipids and voltage sensor paddles detected with tarantula toxins
    Mirela Milescu
    Molecular Physiology and Biophysics Section, Porter Neuroscience Research Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, USA
    Nat Struct Mol Biol 16:1080-5. 2009
    ..voltage-activated potassium (Kv) channels show that voltage-sensor activation is sensitive to the composition of lipids in the surrounding membrane...
  92. pmc Top-down lipidomics reveals ether lipid deficiency in blood plasma of hypertensive patients
    Juergen Graessler
    Department of Internal Medicine III, Carl Gustav Carus Medical School, Technical University Dresden, Dresden, Germany
    PLoS ONE 4:e6261. 2009
    ..The objective of this study was to determine whether hypertension specifically affects the plasma lipidome independently and differently from the effects induced by obesity and insulin resistance...
  93. ncbi Plasma lipid profiles in adults after prenatal exposure to the Dutch famine
    T J Roseboom
    Departments of Clinical Epidemiology and Biostatistics and Obstetrics and Gynecology, The Academic Medical Center, The University of Amsterdam, Netherlands
    Am J Clin Nutr 72:1101-6. 2000
    ..There is no direct evidence in humans that maternal malnutrition during pregnancy affects the lipid profiles of the offspring...
  94. ncbi A novel perspective on stem cell homing and mobilization: review on bioactive lipids as potent chemoattractants and cationic peptides as underappreciated modulators of responsiveness to SDF-1 gradients
    M Z Ratajczak
    Stem Cell Institute, James Graham Brown Cancer Center, University of Louisville, Louisville, KY 40202, USA
    Leukemia 26:63-72. 2012
    ..new evidence shows that, in addition to SDF-1, the migration of HSPCs is directed by gradients of the bioactive lipids sphingosine-1 phosphate and ceramide-1 phosphate...
  95. pmc Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase
    Zheng Zheng Li
    Department of Cell Biology, Cleveland Clinic, Cleveland, Ohio 44195, USA
    J Biol Chem 284:5637-44. 2009
    ..This concept has important implications for the development of novel treatment strategies for patients with this condition...
  96. pmc Leukocyte ABCA1 controls susceptibility to atherosclerosis and macrophage recruitment into tissues
    Miranda Van Eck
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, Sylvius Laboratories, Leiden University, P O Box 9503, 2300 RA Leiden, The Netherlands
    Proc Natl Acad Sci U S A 99:6298-303. 2002
    ..Our results provide evidence that leukocyte ABCA1 plays a critical role in the protection against atherosclerosis, and we identify ABCA1 as a leukocyte factor that controls the recruitment of inflammatory cells...
  97. ncbi Structural determinants that target the hepatitis C virus core protein to lipid droplets
    Steeve Boulant
    Medical Research Council Virology Unit, Institute of Virology, Church St, Glasgow G11 5JR, Scotland, United Kingdom
    J Biol Chem 281:22236-47. 2006
    ..They also serve as a unique model for elucidating the specificity of protein-lipid interactions between two membrane-bound organelles...
  98. pmc Interactions of the apolipoprotein A5 gene polymorphisms and alcohol consumption on serum lipid levels
    Rui xing Yin
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi, People s Republic of China
    PLoS ONE 6:e17954. 2011
    ..The present study was undertaken to detect the interactions of ApoA5-1131T>C, c.553G>T and c.457G>A polymorphisms and alcohol consumption on serum lipid levels...
  99. ncbi Diet, lifestyle, and blood pressure of the middle-aged and elderly in the Guangxi Bai Ku Yao and Han populations
    Yin Ruixing
    Department of Cardiology, Institute of Cardiovascular Diseases, The First Affiliated Hospital, Guangxi Medical University, Nanning, People s Republic of China
    Am J Hypertens 21:382-7. 2008
    ..Bai Ku Yao is an isolated subgroup of the Yao minority in China. Little is known about the association of diet and lifestyle with the prevalence of hypertension in this population...
  100. pmc Root suberin forms an extracellular barrier that affects water relations and mineral nutrition in Arabidopsis
    Ivan Baxter
    Bindley Bioscience Center, Purdue University, West Lafayette, Indiana, USA
    PLoS Genet 5:e1000492. 2009
    ..The changes observed in the elemental accumulation in leaves are also interpreted as evidence that a significant component of the radial root transport of Ca, Mn, and Zn occurs in the apoplast...
  101. ncbi Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores
    Rudolf Zechner
    Institute of Molecular Biosciences, University of Graz, Austria
    J Lipid Res 50:3-21. 2009
    ..This review focuses on the structure, function, and regulation of lipolytic enzymes with a special emphasis on ATGL...

Research Grants77

  1. Discovery metabolite profiling of the prolyl peptidases
    Alan Saghatelian; Fiscal Year: 2009
    ..Furthermore, the application of DMP to peptidases will demonstrate the generality of this approach for the future characterization of medically relevant enzymes and signaling pathways. ..
  2. Mapping for Specialized Domains for FCeRI Signaling &Internalization
    Bridget S Wilson; Fiscal Year: 2013
    ..In Aim 1, we will develop new monovalent probes for plasma membrane lipids. We will use both transmission and X- ray spectral electron microscopy to map the distributions of tagged lipids ..
  3. Comprehensive biomarker study to capitalize on existing GWAS in 10K South Asians
    Danish Saleheen; Fiscal Year: 2010
    ..participants (and assayed the IBC 50K "cardiochip" gene array in 4000 participants) and (4) assayed standard lipids, glucose and HbA1c...
  4. Autonomic, Endothelial, and Inflammatory Correlates of Sleep Duration
    MERCEDES RENEE CARNETHON; Fiscal Year: 2012
    ..Metabolic syndrome components (blood pressure, lipids, glucose, anthropometrics), the prevalence of mood disorders, medical history, and health behaviors will be ..
  5. FASEB SRC on Lysophospholipd Mediators in Health and Disease
    Julie D Saba; Fiscal Year: 2011
    ..The lysophospholipids sphingosine- 1-phosphate (S1P) and lysophosphatidic acid (LPA) are bioactive lipids generated via catabolism of membrane sphingolipids (S1P) and phospholipids (LPA)...
  6. Role of Txnip in adapting fuel metabolism to nutritional state
    SIMON HUI; Fiscal Year: 2013
    ..antioxidant and ROS defense system will be measured as well as the levels of oxidative modified proteins, DNA and lipids in the mitochondria...
  7. Sphingolipid Metabolism in Drosophila Development
    Julie D Saba; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Sphingolipids are a conserved family of lipids built upon a sphingoid base backbone...
  8. Mitochondrial Dysfunction and Adipose Insulin Resistance
    David A Bernlohr; Fiscal Year: 2013
    ..and molecular analyses that point toward the covalent modification of mitochondrial proteins with bioactive lipids and the oxidation of mitochondrial thioredoxin as central to the process...
  9. Monitoring cellular redox signaling and oxidant stress in vivo
    Paul T Schumacker; Fiscal Year: 2010
    ..High levels of ROS cause oxidative damage to proteins, lipids and DNA...
  10. Novel Peptide MPO Inhibitors for Treating Atherosclerosis
    Kirkwood A Pritchard; Fiscal Year: 2012
    ..In turn, MPO oxidizes NO2- to generate nitrogen dioxide ([unreadable]NO2), a radical that is capable of oxidizing lipids, proteins and DNA...
  11. A novel peroxidase in vascular endothelium and the development of atherosclerosis
    Guangjie Cheng; Fiscal Year: 2012
    ..Aim #2 will investigate the oxidative modification of lipoproteins and lipids by VPO. The ability of purified VPO to oxidize LDL lipoprotein and lipid will be emphasized...
  12. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY JUSTIN MUSLIN; Fiscal Year: 2010
    ..Diabetic cardiomyopathy may develop because of the dysfunctional accumulation of lipids in cardiac myocytes...
  13. Pathogenesis of the Metabolic Syndrome
    W Timothy Garvey; Fiscal Year: 2013
    ..Activation of serine kinases is then mediated either directly by medium-chain acylcarnitines and/or by peroxidized lipids generated by mitochondrial ROS that activate inflammatory pathways (e.g., NG-:B)...
  14. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..Finally, it is expected that these studies will reveal additional potential benefits of n-3 PUFA consumption on silica-induced lung disease and fibrosis, another understudied area. ..
  15. NEURAL REGULATION OF PANCREATIC FUNCTION
    KIMBERLY SAUNDERS KIRKWOOD; Fiscal Year: 2012
    ..that 4-hydroxynonenal (HNE), an aldehyde generated by the action of reactive oxygen species (ROS) on membrane lipids, is an endogenous agonist of TRPA1 which causes peptide release, neurogenic inflammation and pain...
  16. Lipid Droplet Metabolism
    Fredric B Kraemer; Fiscal Year: 2013
    ..of LD cholesterol utilization for steroid hormone production and the fact that excessive accumulation of lipids in droplets is a hallmark of obesity, type 2 diabetes, hepatic steatosis, atherosclerosis, and other metabolic ..
  17. Surgical amelioration of type 2 diabetes: Hormones, microbiota and mitochondria
    PETER J contact HAVEL; Fiscal Year: 2010
    ..Monthly measurements of circulating lipids, hormones and bile acids will be taken...
  18. Ceramide Metabolism and Photoreceptor Homeostasis
    Usha R Acharya; Fiscal Year: 2013
    ..components of all eukaryotic cell membranes;many of them like ceramide, sphingosine 1-phosphate are also bioactive lipids regulating cellular functions ranging from apoptosis to angiogenesis...
  19. Role of stearoyl CoA desaturase-1 in TLR5 KO mice colitis and metabolic syndrome
    Matam Vijay Kumar; Fiscal Year: 2013
    ..These MUFA serve as precursors for the synthesis of hepatic lipids (triglycerides (TG) and cholesterol esters (CE) and thus play a role in the development of hepatic steatosis...
  20. FASEB SUMMER CONFERENCE ON PHOSPHOLIPASES
    Alex Brown; Fiscal Year: 2010
    ..widely expressed enzymes hydrolyze ester and phosphodiester bonds in membrane phospholipids to generate bioactive lipids and lipid-derived products that regulated many and diverse aspects of cell function...
  21. Complex I: Role of L Subunit in Proton Translocation
    Steven B Vik; Fiscal Year: 2011
    ..of electron transport can increase the production of superoxide by Complex I, leading to oxidative damage of DNA, lipids, and protein. Loss of Complex I function is associated with the onset of idiopathic Parkinson's disease...
  22. Microsomal Cytochromes P450 and their Interactions with their Redox Partners
    Lucy A Waskell; Fiscal Year: 2013
    ..virtually all steroids (cholesterol, bile acids, estrogens, testosterone, cortisol, and vitamin D) and many lipids and eicosanoids. Cyts P450 exists in virtually every organ and tissue of humans...
  23. Role of MicroRNA mi R-33 in Controlling Cholesterol/Lipid Homeostasis
    Anders M Naar; Fiscal Year: 2010
    ..dysregulation underpinning cardiovascular disease and diabetes, transcriptional regulators of cholesterol/lipids such as SREBPs could potentially represent important therapeutic targets to ameliorate these diseases...
  24. Mitochondrial Dysfunction and Adipose Insulin Resistance
    DAVID BERNLOHR; Fiscal Year: 2009
    ..and molecular analyses that point toward the covalent modification of mitochondrial proteins with bioactive lipids and the oxidation of mitochondrial thioredoxin as central to the process...
  25. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..in the presence f oxygen to produce reactive oxygen species that damage biological molecules such as proteins, lipids and nucleic acids and subsequently cause cell death...
  26. Mechanism(s) of Alcoholic Pancreatitis
    Bhupendra S Kaphalia; Fiscal Year: 2011
    ..found that pancreatic injury along with substantial increases in blood alcohol concentration (BAC) and pancreatic lipids, fatty acid ethyl esters (FAEEs, nonoxidative lipid metabolites of ethanol) and endoplasmic reticulum (ER) stress ..
  27. DNA Repair Deficiency Associated with Obesity and the Metabolic Syndrome
    R Stephen Lloyd; Fiscal Year: 2013
    ..Although it is well established that lipids, proteins and nucleic acids are critical cellular targets for endogenously and exogenously produced ROS, until ..
  28. PET Imaging of Myocardial Oxidative Stress in T2DM
    KOORESH ISAAC SHOGHI; Fiscal Year: 2013
    ..mechanisms it interacts with DNA causing mutations, proteins causing defects or dysfunctional enzymes, and lipids causing damage to cellular membranes...
  29. Undercarboxylated osteocalcin, body fat, and diabetes in older adults
    Ann V Schwartz; Fiscal Year: 2010
    ..also determine whether ucOC levels at baseline predict changes in fasting glucose, A1C and insulin resistance, in lipids (serum triglycerides, total cholesterol, LDLc, HDLc, nonHDLc, and oxidized LDL), and in total fat mass and bone ..
  30. Cholesterol and Lymphatic Transport of Molecules and Cells
    Melody A Swartz; Fiscal Year: 2012
    Lymph is rich in lipids, including lipoproteins, and the return of cholesterol from tissues to the vasculature and ultimately the liver depends not only on the loading of cholesterol onto high-density lipoprotein (HDL) particles within ..
  31. Atypical PKC Knockout Models: Effect on Glucose and Lipid Homeostasis
    Robert V Farese; Fiscal Year: 2013
    ..Mlambda KO mice, Alambda -KO mice are lean and have normal glucose tolerance, normal serum levels of insulin and lipids, and clamp studies reveal increases in hepatic insulin sensitivity and suppression of hepatic glucose output, ..
  32. MECHANISMS OF MILK LIPID SECRETION
    JAMES LEWIS MCMANAMAN; Fiscal Year: 2013
    ..NICHD Health Relatedness: CLD are the source of milk lipids, which are required neonatal growth, and essential fatty acids and cholesterol needed for membrane synthesis, ..
  33. A Culturally Tailored LIfestyle Intervention to Prevent Diabetes in South Asians:
    KABAYAM M VENKAT NARAYAN; Fiscal Year: 2010
    ..are changes in percent body fat, body mass index, waist-to-hip ratio, fasting glucose, blood pressure, plasma lipids, activity, and diet...
  34. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2010
    ..Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial ..
  35. The Postischemia Inflammatory Syndrome in the Aged Kidney
    KATHERINE JULIA KELLY; Fiscal Year: 2013
    ..in vivo in diabetes/obesity and in vitro in cultured renal tubular epithelial cells exposed to proinflammatory lipids. Using this cell culture model to define the mechanisms of ICAM-1 and LOX-1 regulation and alteration of function ..
  36. Protein alterations in skeletal muscle cells with improved mtDNA repair
    Lyudmila I Rachek; Fiscal Year: 2010
    ..oxygen species (ROS) and/or reactive nitrogen species (RNS) directly oxidize and damage DNA, proteins, and lipids and play a key role in the pathogenesis of T2DM...
  37. Lipid Transport, Bile Acid Synthesis, and Cholesterol Homeostasis
    William M Pandak; Fiscal Year: 2013
    ..Consequences of StARD1 overexpression include markedly decreased intracellular neutral lipids (cholesterol and triglycerides), increased levels of key nuclear receptors important in lipid homeostasis, and ..
  38. Asthma Increases Vaso-occlusion in Sickle Cell Disease
    Kirkwood A Pritchard; Fiscal Year: 2013
    ..stress induced by 1) xanthine oxidase (XO);2) myeloperoxidase (MPO);3) cell free hemoglobin (Hb);and, 4) oxidized lipids prevents oxidation of HDL and other lipoproteins in the SCD mice with asthma...
  39. Scavenging of Reactive Oxygen and Nitrogen Species by Cobalamins
    NICOLA ELIZABETH BRASCH; Fiscal Year: 2011
    ..ROS/RNS react with biomolecules including proteins, DNA and lipids, frequently causing irreversible tissue and organ damage...
  40. 5500 QTRAP
    John W Turk; Fiscal Year: 2010
    ..triple quadrupole-linear ion trap mass spectrometer (MS) for LC/MS/MS analyses of biomedically important complex lipids. This program will benefit from the sensitivity and versatility of this contemporary instrument, which can be ..
  41. Mechanisms of Obesity in Mice with Neuron-Specific Lipoprotein Lipase Deficiency
    Robert H Eckel; Fiscal Year: 2013
    ..We believe the clinical relevance of this work relates not only to how dietary lipids carried in lipoproteins control energy balance and body weight, but to mechanisms by which BAT is stimulated and ..
  42. Adipose Tissue Macrophage Phenotype and Function
    Anthony W Ferrante; Fiscal Year: 2013
    ..Adipose tissue development, metabolism and endocrine function are essential for the efficient storage of lipids in adipocytes and for normal systemic metabolism...
  43. Hyperglycemia and Pregnancy Outcome(HAPO)Follow Up Study
    Boyd E Metzger; Fiscal Year: 2013
    ..Its General Aim is to obtain measures of adiposity, glucose, insulin sensitivity and secretion, lipids, inflammation and blood pressure (BP) in 7,000 HAPO mother-offspring (aged 8-12) pairs of multiple ethnic/race ..
  44. Development of a Porcine Model of Atherosclerosis
    Christopher Rogers; Fiscal Year: 2012
    ..Atherosclerosis is characterized by the accumulation of lipids, cholesterol, calcium deposits, and cellular debris in vessel walls, and results in plaque formation, arterial ..
  45. EFFECT OF LIPIDS ON VASCULAR GRAFT HEALING
    Linda M Graham; Fiscal Year: 2013
    ..These studies will lead to a better understanding of the role of lipids in the pathophysiology of graft failure, and provide impetus for development of TRPC6 channel inhibitors or agents ..
  46. Hypo-Lipidemic Actions of Creosote Bush-Derived NDGA
    Salman Azhar; Fiscal Year: 2013
    ..The goal of this project is to elucidate the molecular mechanism by which NDGA lowers elevated blood lipids by improving the lipid metabolism in the liver...
  47. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..lipid, bone density), cardiometabolic risk factors (Specific Aim #2: blood pressure, blood glucose, insulin, lipids, C-reactive protein, adiponectin, leptin, tumor necrosis factor-1, interleukin-6), functional status, and quality ..
  48. Plasma Lipid Markers and Cancer Risk
    Lu Wang; Fiscal Year: 2013
    ..Blood lipids may affect cancer risk through their association with insulin resistance, inflammation and oxidative stress...
  49. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..Therefore, this proposal will investigate how omega-3 fish oils affect inflammation, lipids and fat breakdown by comparing it to a non-fish oil omega-3 supplement (linolenic acid)...
  50. Inflammatory hyperalgesia due to TRPV1, the pepper spray receptor in the cornea
    Sharona E Gordon; Fiscal Year: 2013
    ..Although cell surface receptor-stimulated trafficking of membrane lipids and membrane proteins is of broad significance to biology, the molecular mechanisms by which it occurs are poorly ..
  51. Research Training in Cardiovascular and Pulmonary Diseases
    S Jamal Mustafa; Fiscal Year: 2012
    ..airway and vascular reactivity, lung epithelial pathology, vascular smooth muscle biology, gene expression and lipids, ischemia-reperfusion, reactive oxygen radicals, cell signaling pathways, vascular remodeling, and angiogenesis, ..
  52. Role of Oxidative Stress in Post-MI Cardiac Failure Associated with Diabetes
    MICHAEL FREDERICK HILL; Fiscal Year: 2013
    ..We propose that 8-iso-PGF21 and isoketals (IsoKs), both reactive lipid species formed from oxidation of lipids, play a fundamental role in the greater propensity of diabetic myocardium for oxidative stress injury and ..
  53. Mechanisms and Consequences of Intermittent Hypoxia-Induced Lipolysis
    Jonathan C Jun; Fiscal Year: 2013
    ..FFA are circulating lipids released by adipose tissue during lipolysis, which in excess induce insulin resistance, fatty liver, and ..
  54. Fnip1 Function in Lymphocyte Development, Activation and Metabolism
    Brian M Iritani; Fiscal Year: 2013
    ..phosphorylation, which efficiently produces energy, to aerobic glycolysis, which generates bio-precursors (such as lipids, amino acids, and nucleotides) required to fuel cell division...
  55. INNATE IMMUNE RESPONSE TO MICROBIAL INFECTION
    William M Nauseef; Fiscal Year: 2013
    ..of composition, posttranslational modification, or structure of microbial or host proteins, carbohydrates, or lipids. Application of our analytical approaches and the biological principles they support to study interactions of F...
  56. STRUCTURE-BASED TUBERCULOSIS DRUG DESIGN TARGETED AT ACYL-COA CARBOXYLASE
    Shiou Chuan Tsai; Fiscal Year: 2010
    ..Mycobacterium tuberculosis, the pathogen of tuberculosis (TB), has a cell envelope with chemically complex lipids that are closely related with its virulence and multi-drug resistance...
  57. GENETIC REGULATION OF ALCOHOL METABOLISM IN YEAST
    Elton T Young; Fiscal Year: 2013
    ..a variety of secondary carbon sources, ranging from ethanol and glycerol to complex stored carbohydrates and lipids. To activate these pathways an intricate intracellular signaling cascade is initiated by the protein kinase Snf1 ..
  58. The New England Family Study: Fifty Year Post-Perinatal Follow-Up for Life Course
    ERIC contact LOUCKS; Fiscal Year: 2010
    ..g. lipids). Subcutaneous adipocyte biopsies and buccal cell collection will be performed...
  59. Optimal Selective Thyroid Hormone Analogs for Metabolic Syndrome
    John D Baxter; Fiscal Year: 2010
    ..results for treatment of high low density lipoprotein (LDL) cholesterol and elevations in other atherogenic serum lipids. We now realize, however, that existing STRMs exhibit distinctive combinations of different modes of selectivity;..
  60. Lipid glyceryl ester homeostasis in macrophages and perturbation by environmental
    Matthew K Ross; Fiscal Year: 2012
    ..macrophage foam cells synthesize and release 2AG and PG-Gs into the culture medium and levels of these bioactive lipids are augmented by bioactive metabolites of OP pesticides...
  61. Phospholipid flip-flop in biogenic membranes
    Anant K Menon; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The bi-directional translocation of lipids from one side of a biological membrane to the other is termed flip-flop...
  62. Inhibition of S14 by Conjugated Linoleic Acid in Advanced Solid Tumor Patients
    Raymond P Perez; Fiscal Year: 2010
    ..upregulated de novo lipid synthesis (such as fatty acid synthase (FAS)), and/or increased uptake of circulating lipids derived from diet (lipolysis)...
  63. MOLECULAR MECHANISMS OF OXIDATION OF LDL
    Sampath Parthasarathy; Fiscal Year: 1999
    ..oxidation of LDL may involve the generation of apoB-derived radicals which may initiate peroxidation of LDL lipids. Experiments are proposed to determine optimum conditions for the formation of fluorescent epitopes between ..
  64. High Throughput Cryopreservation of In Vivo-Derived Swine Embryos
    Randall S Prather; Fiscal Year: 2010
    ..One of the most successful methods of cryopreservation of swine embryos is to centrifuge the cells to polarize the lipids and then use a micromanipulator to remove the lipids from the embryo (Nagashima et al., 1995;Nagashima et al...
  65. LIPID MODULATION OF RHODOPSIN SIGNALING IN MEMBRANES
    Michael F Brown; Fiscal Year: 2010
    ..Biophysical methods will characterize the influences of membrane lipids on the Meta I}Meta II transition of rhodopsin...
  66. Development of Chemical Receptors for Proteins
    Sanku Mallik; Fiscal Year: 2005
    ..Synthesis of new polymerizable zwitter-ionic, cationic and hydrogen bond forming lipids; synthesis of new polymerizable lipids capable of complexing either a transition metal ion (e.g., Cu2+, Zn2+ etc...
  67. Structure Based Design of Humanized Monoclonal Antibodies that Recognize Bioactiv
    JONATHAN WOJCIAK; Fiscal Year: 2009
    ..in generating therapeutic monoclonal antibodies (mAbs) against a novel class of therapeutic targets, bioactive lipids. The first bioactive lipid target was sphingosine-1-phosphate (S1P) and our anti-S1P mAbs are in Phase I clinical ..
  68. Longitudinal study of membrane lipids: pre-clinical Alzheimer's biomarkers
    Michelle M Mielke; Fiscal Year: 2010
    ..AD is a progressive neurodegenerative disorder and membrane lipids and lipid metabolites are involved in the neurodegeneration...
  69. DISTRIBUTION AND TRANSPORT OF LIPIDS IN MUCIN GELS
    Timothy Wiedmann; Fiscal Year: 2000
    ..Each surface is exposed to lipids which modulate the viscoelasticity of mucin, but the specific physical chemical interactions between the lipid and ..
  70. Regulation of Mycobacterium tuberculosis proliferation
    Murty Madiraju; Fiscal Year: 2009
    ..regulated during intracellular maintains an active replicative state with increase in bacterial burden, membrane lipids, possibly modulated by LysX, a hitherto unrecognized Z replication and or the factors that in part, on its ..
  71. Adipose Tissue-specific Angiogenesis and Insulin Sensitivity
    Silvia Corvera; Fiscal Year: 2009
    ..Excess calories, in the form of lipids, are ectopically deposited in tissues such as liver and muscle, causing insulin resistance, disordered ..
  72. GLYCEMIC INDEX/GLYCEMIC LOAD AND BLOOD LIPIDS IN THE WHI
    James Shikany; Fiscal Year: 2004
    ..may have an adverse effect on blood glucose and insulin concentrations, resulting in alterations of blood lipids that may increase the risk of developing CHD...
  73. DIETARY ETHER-LINKED LIPIDS AND N-3 FATTY ACIDS
    FRED SNYDER; Fiscal Year: 1993
    ..As with the n-3 fatty acids, fish from the ocean are thought to be highly enriched in ether lipids. The aim of this proposal is to develop a better understanding of the nutritional significance and possible health-..
  74. Identification of Causal Variants at Novel GWAS Loci Associated with Lipid Traits
    DANIEL JAMES RADER; Fiscal Year: 2010
    ..Plasma lipids including low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and ..
  75. NMR STUDIES OF CYTOSOLIC METAL IONS AND OXIDATIVE STRESS
    Raj Gupta; Fiscal Year: 2006
    ..We seek to understand how the regulation of intracellular concentrations of essential metal ions and membrane lipids goes astray in health disorders, especially hypertension and diabetes. Our main research tool is NMR spectroscopy...
  76. High Efficiency Screening of Bioactive Lipids
    MITCHELL JOHNSON; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Fatty acid amides comprise a class of bioactive lipids that are frequently found in mammalian systems at very low concentrations. Function and metabolism are largely unknown...
  77. LUNG ENDOTHELIAL CELL LIPIDS AND TOLERANCE TO HYPEROXIA
    Edward Block; Fiscal Year: 1993
    ..is to test the hypothesis that high partial pressures of O2, which can cause peroxidative cleavage of membrane lipids, alter the fluidity of the lipid bilayer of the plasma membrane of pulmonary endothelial cells, and these ..