thiocyanates

Summary

Summary: Organic derivatives of thiocyanic acid which contain the general formula R-SCN.

Top Publications

  1. ncbi Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    Rajesh K Thimmulappa
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA 21205 2179, USA
    Cancer Res 62:5196-203. 2002
  2. pmc Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    Hongting Zheng
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 60:3055-66. 2011
  3. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
  4. ncbi A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Res 64:5767-74. 2004
  5. ncbi Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells
    Anna Herman-Antosiewicz
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:5828-35. 2006
  6. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
  7. ncbi Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
    Jing Zhao
    Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Neurosci Lett 393:108-12. 2006
  8. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
  9. pmc Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design
    John D Clarke
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Pharmacol Res 64:456-63. 2011
  10. ncbi Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter
    Kyung Jin Woo
    Department of Immunology, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu, 700 712, South Korea
    Int Immunopharmacol 7:1776-83. 2007

Research Grants

Detail Information

Publications282 found, 100 shown here

  1. ncbi Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
    Rajesh K Thimmulappa
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MA 21205 2179, USA
    Cancer Res 62:5196-203. 2002
    ....
  2. pmc Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    Hongting Zheng
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 60:3055-66. 2011
    ..To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy...
  3. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
    ..We propose that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress...
  4. ncbi A novel mechanism of chemoprotection by sulforaphane: inhibition of histone deacetylase
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, Oregon 97331, USA
    Cancer Res 64:5767-74. 2004
    ..Collectively, these findings suggest that SFN may be effective as a tumor-suppressing agent and as a chemotherapeutic agent, alone or in combination with other HDAC inhibitors currently undergoing clinical trials...
  5. ncbi Sulforaphane causes autophagy to inhibit release of cytochrome C and apoptosis in human prostate cancer cells
    Anna Herman-Antosiewicz
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 66:5828-35. 2006
    ..To the best of our knowledge, the present study is the first published report to convincingly document induction of autophagy by an isothiocyanate class of dietary chemopreventive agent...
  6. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
    ..In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism...
  7. ncbi Sulforaphane reduces infarct volume following focal cerebral ischemia in rodents
    Jing Zhao
    Vivian L Smith Center for Neurologic Research, Department of Neurobiology and Anatomy, University of Texas Medical School, P O Box 20708, Houston, TX 77225, USA
    Neurosci Lett 393:108-12. 2006
    ..Delayed administration (15 min) of a single dose of SUL significantly decreased cerebral infarct volume following focal ischemia, suggesting a potential therapeutic value for this compound...
  8. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
    ..The current status of SFN in human clinical trials also is included, with consideration of the chemistry, metabolism, absorption and factors influencing SFN bioavailability...
  9. pmc Bioavailability and inter-conversion of sulforaphane and erucin in human subjects consuming broccoli sprouts or broccoli supplement in a cross-over study design
    John D Clarke
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, OR 97331, USA
    Pharmacol Res 64:456-63. 2011
    ..This has implications for people who consume the recommended serving size (1 pill) of a broccoli supplement and believe they are getting equivalent doses of isothiocyanates...
  10. ncbi Sulforaphane suppresses lipopolysaccharide-induced cyclooxygenase-2 (COX-2) expression through the modulation of multiple targets in COX-2 gene promoter
    Kyung Jin Woo
    Department of Immunology, School of Medicine, Keimyung University, 194 DongSan Dong Jung Gu, Taegu, 700 712, South Korea
    Int Immunopharmacol 7:1776-83. 2007
    ..These results will provide new insights into the anti-inflammatory and anti-carcinogenic properties of sulforaphane...
  11. ncbi Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage
    Xiurong Zhao
    Department of Neurology, University of Texas at Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 38:3280-6. 2007
    ..This study evaluated the role of Nrf2 in protecting the brain from ICH-mediated damage...
  12. ncbi Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    Rong Hu
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen, Piscataway, NJ 08854, USA
    Cancer Lett 243:170-92. 2006
    ....
  13. ncbi Nuclear factor kappa B is a molecular target for sulforaphane-mediated anti-inflammatory mechanisms
    E Heiss
    Deutsches Krebsforschungszentrum Heidelberg, Division of Toxicology and Cancer Risk Factors, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    J Biol Chem 276:32008-15. 2001
    ..Our data provide novel evidence that anti-inflammatory mechanisms contribute to sulforaphane-mediated cancer chemoprevention...
  14. ncbi Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    J Biol Chem 280:19911-24. 2005
    ....
  15. pmc Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate
    Georgios Kallifatidis
    Molecular OncoSurgery, University of Heidelberg, Heidelberg, Germany
    Mol Ther 19:188-95. 2011
    ..No pronounced side effects were observed in normal cells or mice. Our data suggest that SF increases the effectiveness of various cytotoxic drugs against CSCs without inducing additional toxicity in mice...
  16. ncbi Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Biol Chem 279:25813-22. 2004
    ..Activation of Chk2 in response to DNA damage is well documented, but the present study is the first published report to link Chk2 activation to cell cycle arrest by an isothiocyanate...
  17. ncbi Sulforaphane induces thioredoxin through the antioxidant-responsive element and attenuates retinal light damage in mice
    Masaki Tanito
    Department of Biological Responses, Institute for Virus Research, Kyoto University, 53 Shogoin Kawaharacho, Sakyo, Kyoto 606 8507, Japan
    Invest Ophthalmol Vis Sci 46:979-87. 2005
    ....
  18. ncbi Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner
    Chang Deng
    Department of Emergency, The People s Hospital of Guang Du District, Kunming 650200, PR China
    Mol Med Rep 5:847-51. 2012
    ..These results suggest that SF inhibits 6-OHDA-induced cytotoxicity through increasing HO-1 expression in a PI3K/Akt-dependent manner...
  19. pmc Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    Patricia A Egner
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Cancer Prev Res (Phila) 4:384-95. 2011
    ..Cancer Prev Res; 4(3); 384-95. ©2011 AACR...
  20. ncbi Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line
    Andrea Tarozzi
    Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    J Neurochem 111:1161-71. 2009
    ..These findings show that SF may play a role in preventing Parkinson's disease...
  21. ncbi A molecular chaperone inducer protects neurons from ER stress
    T Kudo
    Psychiatry, Department of Integrated Medicine, Division of Internal Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Cell Death Differ 15:364-75. 2008
    ..Considering these results together, it appears that BIX induces BiP to prevent neuronal death by ER stress, suggesting that it may be a potential therapeutic agent for cerebral diseases caused by ER stress...
  22. pmc Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition
    Tiffany Greco
    Department of Anesthesiology and the Center for Shock, Trauma, and Anesthesiology Research, Baltimore, MD, USA
    J Bioenerg Biomembr 42:491-7. 2010
    ..We conclude that SFP confers resistance of brain mitochondria to redox-regulated PTP opening, which could contribute to neuroprotection observed with SFP...
  23. ncbi Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model
    Hyunjin Vincent Kim
    Center for Neuro medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea
    Amyloid 20:7-12. 2013
    ..While the exact mechanism of interaction of SFN in AD has not yet been ascertained, our results suggest that SFN can aid in cognitive impairment and may protect the brain from amyloidogenic damages...
  24. ncbi Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    Larry G Higgins
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 237:267-80. 2009
    ..Thus Nrf2-dependent up-regulation of GSH is the principal mechanism by which sulforaphane pre-treatment induced resistance to acrolein, CuOOH and chlorambucil, but not menadione...
  25. ncbi Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli
    Shikha Saha
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 56:1906-16. 2012
    ..We compared the bioavailability and metabolism of sulforaphane from portions of lightly cooked fresh or frozen broccoli, and investigated the bioconversion of sulforaphane to erucin...
  26. ncbi Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells
    Mi Kyoung Kwak
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyeongsan si, Gyeongsangbuk do 712 749, South Korea
    Free Radic Biol Med 43:809-17. 2007
    ..Therefore, inducers of proteasome expression may ameliorate the accumulation of damaged proteins associated with neurodegeneration and other diseases in whose etiologies protein oxidation plays a role...
  27. ncbi Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
    David Vauzour
    School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights, Reading, UK
    Mol Nutr Food Res 54:532-42. 2010
    ..These data suggest that SFN stimulates the NF-E2-related factor-2 pathway of antioxidant gene expression in neurons and may protect against neuronal injury relevant to the aetiology of Parkinson's disease...
  28. ncbi Role of PI3K/Akt and MEK/ERK signaling pathways in sulforaphane- and erucin-induced phase II enzymes and MRP2 transcription, G2/M arrest and cell death in Caco-2 cells
    Jana Jakubikova
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Biochem Pharmacol 69:1543-52. 2005
    ..Taken together, these results demonstrate that PI3K/Akt and MEK/ERK signals are important intracellular mediators in erucin- and sulforaphane-mediated phase II enzyme transcription and cell cycle arrest in Caco-2 cells...
  29. ncbi Sulforaphane as a promising molecule for fighting cancer
    Carmela Fimognari
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Mutat Res 635:90-104. 2007
    ..Taking into account this evidence and its favorable toxicological profile, SFN can be viewed as a conceptually promising agent in cancer prevention and/or therapy...
  30. ncbi Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage
    Petra Bergström
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Institute of Biomedicine, University of Gothenburg, Bruna Straket 16, SE 413 45 Gothenburg, Sweden
    Neuropharmacology 60:343-53. 2011
    ..The findings also demonstrate that part of this response can be built up by repeated transient stimulation, possibly explaining how intermittent intake of sulforaphane can result in long-term protection from radical-induced disease...
  31. ncbi Synergy between sulforaphane and selenium in the induction of thioredoxin reductase 1 requires both transcriptional and translational modulation
    Jinsong Zhang
    Nutrition Division, Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Carcinogenesis 24:497-503. 2003
    ..These results demonstrate that synergy can result from a combination of induction at the levels of transcription and translation...
  32. pmc Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 99:7610-5. 2002
    ....
  33. ncbi Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
    Chang Joo Oh
    Department of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu 700 721, Republic of Korea
    Free Radic Biol Med 52:671-82. 2012
    ..Collectively, these results show that SFN elicits an antifibrotic effect on hepatic fibrosis through Nrf2-mediated inhibition of the TGF-β/Smad signaling and subsequent suppression of HSC activation and fibrogenic gene expression...
  34. ncbi Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling
    G Kallifatidis
    Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Gut 58:949-63. 2009
    ..The aim of the study was to identify TICs in pancreatic carcinoma for analysis of resistance mechanisms and for definition of sensitising agents...
  35. pmc Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    AAPS J 12:87-97. 2010
    ..Furthermore, we will also discuss the similarities and their potential differences in the regulation of these molecular targets by PEITC and SFN...
  36. ncbi Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism
    Agnieszka Jazwa
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain
    Antioxid Redox Signal 14:2347-60. 2011
    ..These results provide strong pharmacokinetic and biochemical evidence for activation of Nrf2 and phase II genes in the brain and also offer a neuroprotective strategy that may have clinical relevance for PD therapy...
  37. ncbi Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential
    Cristina Angeloni
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Agric Food Chem 57:5615-22. 2009
    ....
  38. ncbi Sulforaphane sensitizes tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistant hepatoma cells to TRAIL-induced apoptosis through reactive oxygen species-mediated up-regulation of DR5
    Heesue Kim
    Institute for Medical Sciences and Department of Surgery, Ajou University School of Medicine, Suwon, South Korea 442 749
    Cancer Res 66:1740-50. 2006
    ....
  39. ncbi The inhibition of autophagy potentiates anti-angiogenic effects of sulforaphane by inducing apoptosis
    Takeshi Nishikawa
    Department of Surgical Oncology, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Angiogenesis 13:227-38. 2010
    ..In the present study, we aimed to investigate the possible role of autophagy induction by ECs as a defense mechanism against SUL...
  40. ncbi p53-independent G1 cell cycle arrest of human colon carcinoma cells HT-29 by sulforaphane is associated with induction of p21CIP1 and inhibition of expression of cyclin D1
    Guoxiang Shen
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, 08854, USA
    Cancer Chemother Pharmacol 57:317-27. 2006
    ....
  41. pmc Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    Syed M Meeran
    Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e11457. 2010
    ..The mechanisms by which SFN imparts its chemopreventive properties are of considerable interest and little is known of its preventive potential for breast cancer...
  42. ncbi Enhancing expression of Nrf2-driven genes protects the blood brain barrier after brain injury
    Jing Zhao
    The Vivian L Smith Center for Neurologic Research and Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA
    J Neurosci 27:10240-8. 2007
    ..These findings indicate a potential therapeutic usefulness for Nrf2-activating molecules to improve the function of the neurovascular unit after injury...
  43. ncbi Growth inhibition, cell-cycle arrest and apoptosis in human T-cell leukemia by the isothiocyanate sulforaphane
    Carmela Fimognari
    Dipartimento di Farmacologia, Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Carcinogenesis 23:581-6. 2002
    ..Sulforaphane therefore deserves study as a potential chemopreventive/chemotherapeutic antileukemic agent...
  44. ncbi Preclinical and clinical evaluation of sulforaphane for chemoprevention in the breast
    Brian S Cornblatt
    Department of Environmental Health Sciences, Johns Hopkins University Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 28:1485-90. 2007
    ..These findings provide a strong rationale for evaluating the protective effects of a broccoli sprout preparation in clinical trials of women at risk for breast cancer...
  45. ncbi Suppression of NF-kappaB and NF-kappaB-regulated gene expression by sulforaphane and PEITC through IkappaBalpha, IKK pathway in human prostate cancer PC-3 cells
    Changjiang Xu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Oncogene 24:4486-95. 2005
    ....
  46. pmc Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
    Mingzhan Xue
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
    Diabetes 57:2809-17. 2008
    ..The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia...
  47. ncbi Induction of BiP, an ER-resident protein, prevents the neuronal death induced by transient forebrain ischemia in gerbil
    Y Oida
    Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
    Brain Res 1208:217-24. 2008
    ..These findings indicate that this selective inducer of BiP could be used to prevent the neuronal damage both in vitro and in vivo...
  48. ncbi Keap1 eye on the target: chemoprevention of liver cancer
    Melinda Sue Yates
    Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Acta Pharmacol Sin 28:1331-42. 2007
    ..However, appropriately designed clinical trials will aid in this process, which can have profound impact on the incidence of HCC...
  49. ncbi A sulforaphane analogue that potently activates the Nrf2-dependent detoxification pathway
    Yasujiro Morimitsu
    Laboratory of Food and Biodynamics and the Division of Biomodeling, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya 464 8601, Japan
    J Biol Chem 277:3456-63. 2002
    ....
  50. ncbi Heating decreases epithiospecifier protein activity and increases sulforaphane formation in broccoli
    Nathan V Matusheski
    Department of Food Science and Human Nutrition, University of Illinois, 499 Bevier Hall, 905 South Goodwin Avenue, Urbana, IL 61801, USA
    Phytochemistry 65:1273-81. 2004
    ..Heating to 70 degrees C and above decreased the formation of both products in broccoli florets, but not in broccoli sprouts. The induction of QR in cultured mouse hepatoma Hepa lclc7 cells paralleled increases in sulforaphane formation...
  51. ncbi Mechanism of sulforaphane-induced cell cycle arrest and apoptosis in human colon cancer cells
    Geraldine Parnaud
    INRA, UMR 1089 Xenobiotiques, 31931 Toulouse, France
    Nutr Cancer 48:198-206. 2004
    ..In summary, we have elucidated part of the mechanism of action of SFN in the concomitant regulation of intestinal cell growth and death...
  52. pmc Sulforaphane improves cognitive function administered following traumatic brain injury
    Pramod K Dash
    Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, United States
    Neurosci Lett 460:103-7. 2009
    ..These studies support the use of sulforaphane in the treatment of TBI, and extend the previously observed protective effects to include enhanced cognition...
  53. ncbi Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme
    Zhang Ping
    Department of Clinical Laboratory, Changzhou No 2 People s Hospital, Jiangsu 213003, PR China
    Brain Res 1343:178-85. 2010
    ..These results demonstrated that SFN could exert neuroprotective effects through increasing Nrf2 and HO-1 expression...
  54. pmc Sulforaphane suppresses polycomb group protein level via a proteasome-dependent mechanism in skin cancer cells
    Sivaprakasam Balasubramanian
    Department of Biochemistry and Molecular Biology University of Maryland School of Medicine, Baltimore, MD 21201, USA
    Mol Pharmacol 80:870-8. 2011
    ..These results suggest that dietary isothiocyanates may suppress cancer progression by reducing PcG protein level via a proteasome-dependent mechanism, thereby inhibiting PcG-dependent pro-survival epigenetic events...
  55. pmc Biological profile of erucin: a new promising anticancer agent from cruciferous vegetables
    Antonietta Melchini
    Foundation Prof Antonio Imbesi, Pharmaco Biological Department, School of Pharmacy, University of Messina Villaggio Annunziata, 98168 Messina, Italy
    Toxins (Basel) 2:593-612. 2010
    ..These mechanisms include modulation of phase I, II and III detoxification, regulation of cell growth by induction of apoptosis and cell cycle arrest, induction of ROS-mechanisms and regulation androgen receptor pathways...
  56. ncbi Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin
    Hila Yehuda
    Laboratory of Human Health and Nutrition Sciences, Migal Galilee Technology Center, P O Box 831, 11016 Kiryat Shmona, Israel
    Inflamm Res 61:735-42. 2012
    ..4-Methylthiobutylisothiocyanate (MTBI), the main rocket (Eruca sativa) seed isothiocyanate (ITC), and its oxidized form, sulforaphane (SFN), were assessed for their potential effects on psoriasis-related factors...
  57. ncbi Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats
    Leobardo Gaona-Gaona
    Departamento de Biologia, Facultad de Química UNAM, UNAM, Mexico, D F, Mexico
    Toxicology 286:20-7. 2011
    ..The hepatoprotective effect of SFN was associated to the preservation of mitochondrial function, antioxidant enzymes and prevention of liver and mitochondrial oxidant stress...
  58. pmc Sulforaphane activates heat shock response and enhances proteasome activity through up-regulation of Hsp27
    Nanqin Gan
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    J Biol Chem 285:35528-36. 2010
    ..This is the first report to show that heat shock response by SFN, in addition to the antioxidant response mediated by the Keap1-Nrf2 pathway, may contribute to cytoprotection...
  59. pmc The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice
    Yuan Hong
    Department of Neurosurgery, 2nd Affiliated Hospital, Zhejiang University, Hangzhou, China
    Acta Pharmacol Sin 31:1421-30. 2010
    ..To determine whether Nrf2 signaling pathway activation could attenuate oxidative stress and neuronal damage following traumatic brain injury (TBI)...
  60. ncbi Synergistic inhibitory effect of sulforaphane and 5-fluorouracil in high and low metastasis cell lines of salivary gland adenoid cystic carcinoma
    Xiao Feng Wang
    Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital of Harbin Medical University, PR China
    Phytother Res 23:303-7. 2009
    ..Our results demonstrate synergism between SFN and 5-Fu at higher doses against the ACC-M and ACC-2 cells, which was associated with the decreased expression of nuclear NF-kappaB p65 protein...
  61. pmc Inhibition of bladder cancer by broccoli isothiocyanates sulforaphane and erucin: characterization, metabolism, and interconversion
    Besma Abbaoui
    The Ohio State University, Columbus, OH 43210, USA
    Mol Nutr Food Res 56:1675-87. 2012
    ..Our objectives are to investigate these observations and determine the role of isothiocyanates in primary or secondary bladder cancer prevention...
  62. pmc Organ-specific exposure and response to sulforaphane, a key chemopreventive ingredient in broccoli: implications for cancer prevention
    Omkara L Veeranki
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Br J Nutr 109:25-32. 2013
    ..These findings may provide a basis for prioritising organs for further chemopreventive study of SF...
  63. ncbi The dietary isothiocyanate sulforaphane targets pathways of apoptosis, cell cycle arrest, and oxidative stress in human pancreatic cancer cells and inhibits tumor growth in severe combined immunodeficient mice
    Nhu An Pham
    Department of Medical Biophysics, University of Toronto, Ontario, Canada
    Mol Cancer Ther 3:1239-48. 2004
    ..Our findings suggest that, in addition to the known effects on cancer prevention, sulforaphane may have activity in established pancreatic cancer...
  64. ncbi Sulforaphane protects kidneys against ischemia-reperfusion injury through induction of the Nrf2-dependent phase 2 enzyme
    Ha Yong Yoon
    Department of Biochemistry, Medical School and Institute for Medical Sciences, Chonbuk National University, Jeonju, Jeonbuk 561 756, Republic of Korea
    Biochem Pharmacol 75:2214-23. 2008
    ..Collectively, these results suggest that sulforaphane can be used as an effective adjunct for the prevention of renal oxidative insults during ischemia-reperfusion injury...
  65. ncbi Bioavailability and kinetics of sulforaphane in humans after consumption of cooked versus raw broccoli
    Martijn Vermeulen
    TNO Quality of Life, AJ Zeist, The Netherlands
    J Agric Food Chem 56:10505-9. 2008
    ..5). This study gives complete kinetic data and shows that consumption of raw broccoli results in faster absorption, higher bioavailability, and higher peak plasma amounts of sulforaphane, compared to cooked broccoli...
  66. ncbi The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Anticancer Drugs 17:297-305. 2006
    ..These data show that the NAC-ITCs are biologically similar to their parent compounds and are highly effective against human bladder cancer cells...
  67. pmc Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells
    Xiang Lin Tan
    Division of Pulmonary Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Nutr 140:1404-10. 2010
    ..We conclude that modulation of lung cell phase II metabolism by chemopreventive agents requires cell- and agent-specific discovery and testing...
  68. pmc Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    John D Clarke
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
    Pharm Res 28:3171-9. 2011
    ..To determine the metabolism and tissue distribution of the dietary chemoprotective agent sulforaphane following oral administration to wild-type and Nrf2 knockout (Nrf2(-/-)) mice...
  69. ncbi Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Acta Pharmacol Sin 28:1343-54. 2007
    ....
  70. ncbi Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    Rong Hu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:2038-46. 2006
    ....
  71. ncbi Inhibition of angiogenesis and endothelial cell functions are novel sulforaphane-mediated mechanisms in chemoprevention
    Elisabeth Bertl
    Division of Toxicology and Cancer Risk Factors, German Cancer Research Center, C010 2 Chemoprevention, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
    Mol Cancer Ther 5:575-85. 2006
    ..These novel antiangiogenic activities of sulforaphane are likely to contribute to its cancer chemopreventive and therapeutic potential...
  72. ncbi Effect of sulforaphane on metallothionein expression and induction of apoptosis in human hepatoma HepG2 cells
    Chi Tai Yeh
    Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan
    Carcinogenesis 26:2138-48. 2005
    ..The results from this study may provide more evidence for its chemopreventive function...
  73. ncbi Sulforaphane protects against cytokine- and streptozotocin-induced beta-cell damage by suppressing the NF-kappaB pathway
    Mi Young Song
    Department of Biochemistry, Medical School and Diabetes Research Center, Chonbuk National University, Jeonju, Jeonbuk, 561 756, Republic of Korea
    Toxicol Appl Pharmacol 235:57-67. 2009
    ..Furthermore, pretreatment with SFN blocked the development of type 1 diabetes in streptozotocin-treated mice...
  74. ncbi Erucin, a new promising cancer chemopreventive agent from rocket salads, shows anti-proliferative activity on human lung carcinoma A549 cells
    A Melchini
    Dip Farmaco Biologico, Facolta di Farmacia, Universita di Messina, Villaggio Annunziata, 98168 Messina, Italy
    Food Chem Toxicol 47:1430-6. 2009
    ..The ability of dietary compounds to modulate molecular mechanisms that affect cancer cell proliferation is certainly a key point of the cancer prevention potential by functional foods...
  75. ncbi Modulation of rat pulmonary carcinogen-metabolising enzyme systems by the isothiocyanates erucin and sulforaphane
    Natalya Hanlon
    Centre of Toxicology, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Chem Biol Interact 177:115-20. 2009
    ..It is concluded that these aliphatic isothiocyanates have the potential to antagonise the carcinogenicity of pulmonary carcinogens by stimulating the in situ detoxication of their DNA-binding genotoxic metabolites...
  76. pmc Oral sulforaphane increases Phase II antioxidant enzymes in the human upper airway
    Marc A Riedl
    The Hart and Louis Laboratory, Clinical Immunology and Allergy, Department of Medicine, UCLA David Geffen School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095, USA
    Clin Immunol 130:244-51. 2009
    ..Endogenous Phase II enzymes abrogate oxidative stress through the scavenging of reactive oxygen species and metabolism of reactive chemicals...
  77. pmc Sulforaphane protects astrocytes against oxidative stress and delayed death caused by oxygen and glucose deprivation
    Camelia A Danilov
    Department of Anesthesiology, University of Maryland School of Medicine, Baltimore, Maryland, USA
    Glia 57:645-56. 2009
    ..We conclude that sulforaphane stimulates the NRF2 pathway of antioxidant gene expression in astrocytes and protects them from cell death in an in vitro model of ischemia/reperfusion...
  78. pmc A novel host defense system of airways is defective in cystic fibrosis
    Patryk Moskwa
    Department of Anatomy, University of Iowa, Coralville, IA 52241, USA
    Am J Respir Crit Care Med 175:174-83. 2007
    ..Defective airway immunity characterizes cystic fibrosis (CF), a disease caused by mutations in the CF transmembrane conductance regulator, a chloride channel. The pathophysiology of defective immunity in CF remains to be elucidated...
  79. ncbi Sulforaphane: a naturally occurring mammary carcinoma mitotic inhibitor, which disrupts tubulin polymerization
    Steven J T Jackson
    Department of Food Science and Human Nutrition, University of Illinois, 467 Bevier Hall M C 182, 905 S Goodwin Ave, Urbana, IL 61801, USA
    Carcinogenesis 25:219-27. 2004
    ..Inhibition of mammary carcinogenesis appears in part to involve perturbation of mitotic microtubules and early M-phase block associated with cdc2 kinase activation, indicating that cells arrest prior to metaphase exit...
  80. pmc Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells
    Shivendra V Singh
    Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, USA
    Cancer Res 69:2117-25. 2009
    ..In conclusion, the results of the present study indicate that SFN administration inhibits prostate cancer progression and pulmonary metastasis in TRAMP mice by reducing cell proliferation and augmenting NK cell lytic activity...
  81. pmc Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells
    Hyon Jeen Kim
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, CA 90095, USA
    J Allergy Clin Immunol 121:1255-1261.e7. 2008
    ..Recent studies suggest that the redox equilibrium of dendritic cells (DCs) is a key factor in maintaining protective cellular immunity and that a disturbance of this homeostatic mechanism could contribute to immune senescence...
  82. ncbi Nrf2 activators provide neuroprotection against 6-hydroxydopamine toxicity in rat organotypic nigrostriatal cocultures
    Aubrey Siebert
    Department of Neurology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci Res 87:1659-69. 2009
    ..Overall, these results suggest that Nrf2 may play an important role in cellular protection in neurodegenerative diseases and may be a viable therapeutic target in the future...
  83. pmc The NRF2-heme oxygenase-1 system modulates cyclosporin A-induced epithelial-mesenchymal transition and renal fibrosis
    Dong Ha Shin
    College of Pharmacy, Yeungnam University, Gyeongsan si, Gyeongsangbuk do 712 749, South Korea
    Free Radic Biol Med 48:1051-63. 2010
    ..Collectively, our results suggest that the NRF2-HO-1 system plays a protective role against CsA-induced renal fibrosis by modulating EMT gene changes...
  84. ncbi Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion
    Joell J Gills
    Department of Medicinal Chemistry and Pharmacognosy, University of Illinois at Chicago, Chicago, IL 60612, USA
    Cancer Lett 236:72-9. 2006
    ..These data link this molecular mechanism to SF-dependent inhibition of the promotion of tumorigenesis...
  85. ncbi Sulforaphane inhibits the growth of KPL-1 human breast cancer cells in vitro and suppresses the growth and metastasis of orthotopically transplanted KPL-1 cells in female athymic mice
    Sayaka Kanematsu
    Department of Pathology II, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    Oncol Rep 26:603-8. 2011
    ....
  86. ncbi Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate
    Jin Sun Kong
    Catholic University of Korea, Seoul, South Korea
    Arthritis Rheum 62:159-70. 2010
    ..To investigate whether sulforaphane (SFN), an isothiocyanate derived from cruciferous vegetables such as broccoli, regulates synoviocyte hyperplasia and T cell activation in rheumatoid arthritis (RA)...
  87. ncbi MTBITC mediates cell cycle arrest and apoptosis induction in human HepG2 cells despite its rapid degradation kinetics in the in vitro model
    Evelyn Lamy
    Department of Environmental Health Sciences, University Medical Center Freiburg, Freiburg, Germany
    Environ Mol Mutagen 50:190-200. 2009
    ....
  88. ncbi The role of protein binding in induction of apoptosis by phenethyl isothiocyanate and sulforaphane in human non-small lung cancer cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia 20057, USA
    Cancer Res 67:6409-16. 2007
    ..Because PEITC is a stronger inducer of apoptosis than SFN, these results indicate that direct covalent binding to cellular proteins is an important early event in the induction of apoptosis by the ITCs...
  89. ncbi Hypothiocyanous acid is a more potent inducer of apoptosis and protein thiol depletion in murine macrophage cells than hypochlorous acid or hypobromous acid
    Mitchell M Lloyd
    The Heart Research Institute, 114 Pyrmont Bridge Road, Camperdown, Sydney, NSW 2050, Australia
    Biochem J 414:271-80. 2008
    ..This induction of damage by HOSCN may be of critical importance in people with elevated levels of SCN(-) (thiocyanate ions) arising from cigarette smoking, and plays a role in the pathologies associated with this biological insult...
  90. pmc Chemoprotection by sulforaphane: keep one eye beyond Keap1
    Melinda C Myzak
    Linus Pauling Institute, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 233:208-18. 2006
    ..The present review discusses the more widely established chemoprotective mechanisms of SFN, but makes the case for additional work on mechanisms that might be of importance during later stages of carcinogenesis, beyond Keap1...
  91. ncbi Hypothiocyanous acid reactivity with low-molecular-mass and protein thiols: absolute rate constants and assessment of biological relevance
    Ojia Skaff
    The Heart Research Institute, Newtown, Sydney, NSW, Australia
    Biochem J 422:111-7. 2009
    ....
  92. pmc The lactoperoxidase system links anion transport to host defense in cystic fibrosis
    Gregory E Conner
    Division of Pulmonary and Critical Care Medicine, University of Miami School of Medicine, Miami, FL 33136, United States
    FEBS Lett 581:271-8. 2007
    ..The lower CF [SCN-] did not support LPO antibacterial activity. Modeling of airway LPO activity suggested that reduced transport impairs LPO-mediated defense and cannot be compensated by LPO or H2O2 upregulation...
  93. ncbi Reaction of lactoperoxidase compound I with halides and thiocyanate
    Paul Georg Furtmüller
    Institute of Chemistry, University of Agricultural Sciences, Muthgasse 18, A 1190 Vienna, Austria
    Biochemistry 41:11895-900. 2002
    ..0 x 10(8) M(-1) s(-1)), whereas chloride cannot function as electron donor. The results are discussed with respect to known kinetic data of homologous mammalian peroxidases and to the physiological role of LPO in antimicrobial defense...
  94. ncbi Towards engineering glucosinolates into non-cruciferous plants
    Fernando Geu-Flores
    Plant Biochemistry Laboratory, VKR Research Centre Pro Active Plants, Department of Plant Biology and Biotechnology, Faculty of Life Sciences, University of Copenhagen, 40 Thorvaldsensvej, 1871, Frederiksberg C, Denmark
    Planta 229:261-70. 2009
    ..In summary, we transferred the last three steps of the benzylglucosinolate pathway to tobacco as a first step towards engineering glucosinolates into non-cruciferous plants...
  95. ncbi Kinetics and mechanisms of the reaction of hypothiocyanous acid with 5-thio-2-nitrobenzoic acid and reduced glutathione
    Peter Nagy
    Department of Pathology, University of Otago Christchurch, P O Box 4345, Christchurch, New Zealand
    Chem Res Toxicol 22:1833-40. 2009
    ..As the reaction occurs strictly with the thiolate, this oxidant should selectively target proteins containing low pK(a) thiols...
  96. ncbi Glycine conjugates in a lepidopteran insect herbivore--the metabolism of benzylglucosinolate in the cabbage white butterfly, Pieris rapae
    Fredd Vergara
    Max Planck Institute for Chemical Ecology, Beutenberg Campus, Hans Knoll Strasse 8, 07745 Jena, Germany
    Chembiochem 7:1982-9. 2006
    ..rapae faeces extracts. This is the first description of such conjugates from lepidopteran insects...
  97. ncbi Dietary isothiocyanates modify mitochondrial functions through their electrophilic reaction
    Makiko Kawakami
    Department of Biochemistry, School of Medicine, Fujita Health University, Toyoake, Japan
    Biosci Biotechnol Biochem 69:2439-44. 2005
    ....
  98. ncbi Effect of sulforaphane on micronucleus induction in cultured human lymphocytes by four different mutagens
    Carmela Fimognari
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Environ Mol Mutagen 46:260-7. 2005
    ..Taken together, our findings indicate that under certain conditions sulforaphane possesses anti-genotoxic activity in vitro and that further studies are warranted to characterize this property in vivo...
  99. ncbi Protective effect of combination of sulforaphane and riluzole on glutamate-mediated excitotoxicity
    Geng Chang
    Department of Neurology, The Second Hospital of Hebei Medical University, Hebei, China
    Biol Pharm Bull 33:1477-83. 2010
    ..When used at low doses, the combination is better than each agent used alone. In conclusion, these results suggest the potential utility of combination use of SF and riluzole for protection of motor neuron against excitotoxicity...
  100. ncbi Optical fiber based methodology for assessment of thiocyanate in seawater
    Lurdes I B Silva
    CESAM and Department of Chemistry, University of Aveiro, Campus Universitario de Santiago, 3810 193 Aveiro, Portugal
    J Environ Monit 13:1811-5. 2011
    ..The OF based methodology was of compact design and easy operation. This simple system has the potential to be used as a sensing approach for SCN(-) in seawater...
  101. ncbi Sulforaphane induces DNA single strand breaks in cultured human cells
    Piero Sestili
    Dipartimento di Scienze Biomolecolari, Via Maggetti, 21, Universita degli Studi di Urbino Carlo Bo, 61029 Urbino, PU, Italy
    Mutat Res 689:65-73. 2010
    ....

Research Grants27

  1. Cardiovascular Consequences of Thyroid Dysfunction
    Elizabeth Pearce; Fiscal Year: 2007
    ..Pearce's career as an independent academic clinical investigator with a focus on thyroid disease and epidemiology. ..
  2. Inorganic Antimicrobials in Exocrine Fluids
    Michael Ashby; Fiscal Year: 2008
    ..The ultimate objective of our research is the development of specific approaches to reduce pathogenic flora without altering the normal commensal (non-injurious) flora of the oral cavity. [unreadable] [unreadable] [unreadable]..
  3. Bioactive Food Comoponents, Alternative Medicine and Cancer Chemoprevention: Rece
    Shivendra Singh; Fiscal Year: 2007
    ..The theme of our symposium is highly focused and attracts leaders and highly accomplished scientists to discuss promises and challenges in cancer chemoprevention research. [unreadable] [unreadable] [unreadable] [unreadable]..
  4. Chemopreventive Efficacy of Broccoli Sprouts in Humans
    Thomas Kensler; Fiscal Year: 2004
    ..abstract_text> ..
  5. Protection by Induction of Ubiquitin-Proteasome Systems
    Thomas Kensler; Fiscal Year: 2005
    ....
  6. REGULATION OF AIRWAY LACTOPEROXIDASE HOST DEFENSE
    Gregory Conner; Fiscal Year: 2009
    ..Lav Summary: These experiments will provide new information about physiological defects in cystic fibrosis patients that may lead to new therapeutic approaches to treating this disease. ..
  7. Prefrontal cortex and memory storage
    Pramod K Dash; Fiscal Year: 2010
    ....
  8. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  9. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..abstract_text> ..
  10. Mechanisms of Chemoprevention by Resveratrol
    Rakesh Srivastava; Fiscal Year: 2009
    ..Thus, resveratrol based strategies can be utilized for prevention and treatment of prostate cancer, and in the long-term it may have profound impact on the overall incidence of human prostate cancer. ..
  11. MODULATION OF COLON CARCINOGENESIS BY CHLOROPHYLLIN
    Roderick Dashwood; Fiscal Year: 2008
    ..3C. Determine CHL effects on beta-catenin nuclear export and Adherins junction remodeling. 3D. Assess direct effects of CHL on a downstream target of beta-catenin, c-Jun. ..
  12. Incident cancer studies in a unique arsenic-exposed area of Chile
    Craig M Steinmaus; Fiscal Year: 2010
    ..Information on early-life exposure, MMA3, diet, and the future genetic and proteomic studies we will plan as part of this project could add further insight into the important co-factors and mechanisms of environmental carcinogenesis. ..
  13. LONG TERM HIPPOCAMPAL MEMORY
    Pramod Dash; Fiscal Year: 2001
    ..Understanding the molecular basis of memory storage will be of value in the future development of pharmacological agents to treat amnesia associated with neurological disorders and other mental health related problems. ..
  14. Working memory deficits following brain trauma
    Pramod Dash; Fiscal Year: 2009
    ..An understanding of the mechanisms by which TBI alters dopamine signaling is critical for the development of mechanism-based intelligent pharmacological treatments for working memory deficits for brain trauma patients. ..
  15. Hybrid triple quadrupole linear ion trap mass spectrometer
    Jan Stevens; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  16. ROLE OF HUMAN GST PI POLYMORPHISM IN DRUG RESISTANCE
    Shivendra Singh; Fiscal Year: 2003
    ..These studies, in the long term, may be valuable in identifying subjects that may be at a higher risk for developing GST-mediated resistance to some alkylating agents. ..
  17. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  18. NOVEL GST AND DETOXICATION OF DIOL EPOXIDES
    Shivendra Singh; Fiscal Year: 2006
    ..In the long-term, this knowledge will guide us in developing strategies for prevention of PAH-induced cancers in humans. ..
  19. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  20. STUDIES IN ALKALOID TOTAL SYNTHESIS
    STEVEN WEINREB; Fiscal Year: 2003
    ..In all of these projects a strong emphasis has been placed on developing new, practical methods of organic synthesis. ..
  21. MECHANISM OF ANTICARCINOGENIC ACTIVITY--ORGANOSULFIDES
    Shivendra Singh; Fiscal Year: 2003
    ..Insights gained from these studies should help in devising practical dietary recommendation for humans. ..
  22. Chemical Studies on Anticancer Natural Products
    STEVEN WEINREB; Fiscal Year: 2007
    ..A total synthesis of the unusual cyclopropane-containing alkaloid lundurine A is in progress and will be completed, as will a new stereoselective total synthesis of the immunosuppressant agent FR901483. ..
  23. MECHANISMS OF MEMORY DEFICITS FOLLOWING BRAIN INJURY
    Pramod Dash; Fiscal Year: 2006
    ..Furthermore, this project will broaden our understanding of the pathogenesis of neurodegenerative diseases such as stroke and Alzheimer's disease. ..
  24. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    ..Aim 5 will determine the efficacy of an orally administered ITC in inhibiting N-butyl-N- (4-hydroxybutyl)-nitrosamine-induced bladder tumorigenesis in F344 rats. ..
  25. Ascorbylation of Oxidized Lipids and Atherosclerosis
    Jan Frederik Stevens; Fiscal Year: 2010
    ..This project contributes to our long- term goal to determine the role of lipid peroxidation in inflammatory and age-related disease and how its effects can be modulated by therapeutic or dietary intervention. ..
  26. Toxicological Relevance of Human GST P1-1 Polymorphism
    Shivendra Singh; Fiscal Year: 2005
    ..abstract_text> ..