thiazines

Summary

Top Publications

  1. ncbi Comparison of the influence of NSAIDs with different COX-selectivity on histamine release from mast cells isolated from naïve and sensitized rats
    Nina Grosman
    Department of Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Int Immunopharmacol 7:532-40. 2007
  2. pmc Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
    Vadim Makarov
    A N Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia
    Science 324:801-4. 2009
  3. ncbi Mammalian sweet taste receptors
    G Nelson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
    Cell 106:381-90. 2001
  4. ncbi Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection
    M A Michelin
    Department of Biological Sciences, Immunology, Federal School of Medicine, Uberaba, MG, Brazil
    Exp Parasitol 111:71-9. 2005
  5. ncbi Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species
    K Baert
    Department of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Comp Biochem Physiol C Toxicol Pharmacol 134:25-33. 2003
  6. ncbi Meloxicam in rheumatoid arthritis
    Mansoor Ahmed
    David Geffen School of Medicine, Los Angeles, CA, USA
    Expert Opin Drug Metab Toxicol 1:739-51. 2005
  7. pmc Assessment of behavioral changes associated with oral meloxicam administration at time of dehorning in calves using a remote triangulation device and accelerometers
    Miles E Theurer
    Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, USA
    BMC Vet Res 8:48. 2012
  8. ncbi Paw inflammation model in dogs for preclinical pharmacokinetic/pharmacodynamic investigations of nonsteroidal anti-inflammatory drugs
    E C Jeunesse
    Toxalim, Institut National de la Recherche Agronomique, Toulouse, France
    J Pharmacol Exp Ther 338:548-58. 2011
  9. ncbi (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents
    V Cecchetti
    Istituto di Chimica e Tecnologia del Farmaco, Universita di Perugia, Italy
    Bioorg Med Chem Lett 10:465-8. 2000
  10. pmc Phase 3 randomized 3-month trial with an ongoing 3-month safety extension of fixed-combination brinzolamide 1%/brimonidine 0.2%
    Quang H Nguyen
    Scripps Clinic, La Jolla, CA 92037, USA
    J Ocul Pharmacol Ther 29:290-7. 2013

Detail Information

Publications225 found, 100 shown here

  1. ncbi Comparison of the influence of NSAIDs with different COX-selectivity on histamine release from mast cells isolated from naïve and sensitized rats
    Nina Grosman
    Department of Pharmacology, The Panum Institute, University of Copenhagen, Blegdamsvej 3, DK 2200 Copenhagen N, Denmark
    Int Immunopharmacol 7:532-40. 2007
    ..The results seem to exclude toxic effects on mast cell energy production but are consistent with an interference with the calcium disposition...
  2. pmc Benzothiazinones kill Mycobacterium tuberculosis by blocking arabinan synthesis
    Vadim Makarov
    A N Bakh Institute of Biochemistry, Russian Academy of Science, 119071 Moscow, Russia
    Science 324:801-4. 2009
    ..The most advanced compound, BTZ043, is a candidate for inclusion in combination therapies for both drug-sensitive and extensively drug-resistant TB...
  3. ncbi Mammalian sweet taste receptors
    G Nelson
    Howard Hughes Medical Institute, University of California at San Diego, La Jolla, CA 92093, USA
    Cell 106:381-90. 2001
    ..Finally, we present a detailed analysis of the patterns of expression of T1Rs and T2Rs, thus providing a view of the representation of sweet and bitter taste at the periphery...
  4. ncbi Inducible cyclooxygenase released prostaglandin mediates immunosuppression in acute phase of experimental Trypanosoma cruzi infection
    M A Michelin
    Department of Biological Sciences, Immunology, Federal School of Medicine, Uberaba, MG, Brazil
    Exp Parasitol 111:71-9. 2005
    ..In conclusion, the results suggest that the prostaglandins produced mainly by COX-2 mediate the immunosuppression observed in the acute phase of T. cruzi infection...
  5. ncbi Comparative pharmacokinetics of three non-steroidal anti-inflammatory drugs in five bird species
    K Baert
    Department of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B 9820 Merelbeke, Belgium
    Comp Biochem Physiol C Toxicol Pharmacol 134:25-33. 2003
    ..The half-life of chickens and pigeons was three-fold as long as the other bird species for meloxicam, and, for salicylic acid, the half-life in pigeons was at least three-five-fold longer than in the other bird species...
  6. ncbi Meloxicam in rheumatoid arthritis
    Mansoor Ahmed
    David Geffen School of Medicine, Los Angeles, CA, USA
    Expert Opin Drug Metab Toxicol 1:739-51. 2005
    ..Clinical trials have shown that meloxicam at 7.5 - 15 mg/day is as effective as diclofenac, piroxicam and naproxen as an anti-inflammatory and analgesic, and was associated with fewer GI adverse effects...
  7. pmc Assessment of behavioral changes associated with oral meloxicam administration at time of dehorning in calves using a remote triangulation device and accelerometers
    Miles E Theurer
    Department of Diagnostic Medicine and Pathobiology, Kansas State University, Manhattan, USA
    BMC Vet Res 8:48. 2012
    ..Accelerometers monitored lying behavior and the remote triangulation device was used to monitor each calf's movement within the pen...
  8. ncbi Paw inflammation model in dogs for preclinical pharmacokinetic/pharmacodynamic investigations of nonsteroidal anti-inflammatory drugs
    E C Jeunesse
    Toxalim, Institut National de la Recherche Agronomique, Toulouse, France
    J Pharmacol Exp Ther 338:548-58. 2011
    ..These in vivo IC(50) values require approximately 80 (antipyretic effect) to 90% (all other effects) cyclooxygenase-2 inhibition as calculated ex vivo whole-blood assay data...
  9. ncbi (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents
    V Cecchetti
    Istituto di Chimica e Tecnologia del Farmaco, Universita di Perugia, Italy
    Bioorg Med Chem Lett 10:465-8. 2000
    ..Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands...
  10. pmc Phase 3 randomized 3-month trial with an ongoing 3-month safety extension of fixed-combination brinzolamide 1%/brimonidine 0.2%
    Quang H Nguyen
    Scripps Clinic, La Jolla, CA 92037, USA
    J Ocul Pharmacol Ther 29:290-7. 2013
    ..2% (BBFC) with that of its component medications, brinzolamide and brimonidine, in patients with open-angle glaucoma or ocular hypertension...
  11. ncbi The effect of meloxicam on behavior and pain sensitivity of dairy calves following cautery dehorning with a local anesthetic
    A Heinrich
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1
    J Dairy Sci 93:2450-7. 2010
    ..62+/-0.13 kg of force and 2.13+/-0.15 kg of force for control and meloxicam calves, respectively). Changes in behavior suggest that meloxicam was effective for reducing post-surgical pain and distress associated with calf dehorning...
  12. ncbi Effects of vasectomy surgery and meloxicam treatment on faecal corticosterone levels and behaviour in two strains of laboratory mouse
    Siân L Wright-Williams
    Comparative Biology Centre, University of Newcastle upon Tyne, Framlington Place, Newcastle upon Tyne NE2 4HH, UK
    Pain 130:108-18. 2007
    ..Vasectomy elicits a rise in corticosterone levels that was only reduced by the highest dose of meloxicam...
  13. ncbi Drug-dependent requirement of hippocampal neurogenesis in a model of depression and of antidepressant reversal
    Alexandre Surget
    U930, INSERM, Universite Francois Rabelais de Tours, Tours, France
    Biol Psychiatry 64:293-301. 2008
    ..We investigated causality between changes in hippocampal neurogenesis and the effects of both chronic stress and chronic ADs...
  14. ncbi Benzothiazinones: prodrugs that covalently modify the decaprenylphosphoryl-β-D-ribose 2'-epimerase DprE1 of Mycobacterium tuberculosis
    Claudia Trefzer
    New Medicines for Tuberculosis Consortium, Institute of Chemical Sciences and Engineering, Ecole Polytechnique Federale de Lausanne, CH 1015 Lausanne, Switzerland
    J Am Chem Soc 132:13663-5. 2010
    ..Here we demonstrate that BTZs are activated in the bacterium by reduction of an essential nitro group to a nitroso derivative, which then specifically reacts with a cysteine residue in the active site of DprE1...
  15. pmc Decaprenylphosphoryl-β-D-ribose 2'-epimerase, the target of benzothiazinones and dinitrobenzamides, is an essential enzyme in Mycobacterium smegmatis
    Paul K Crellin
    Department of Microbiology, Australian Research Council Centre of Excellence in Structural and Functional Microbial Genomics, Monash University, Victoria, Australia
    PLoS ONE 6:e16869. 2011
    ..Indeed, direct experimental evidence of the essentiality of DprE1 has not been obtained in any species of mycobacterium...
  16. ncbi Enhanced protection by melatonin and meloxicam combination in experimental infection by Trypanosoma cruzi
    L G R Oliveira
    Laboratorio de Parasitologia, Departamento de Analises Clinicas, Toxicologicas e Bromatologicas, Faculdade de Ciências Farmacêuticas de Ribeirao Preto FCFRP USP, Universidade de Sao Paulo, Ribeirao Preto, SP, Brasil
    Parasite Immunol 32:245-51. 2010
    ..Therefore, our results suggest that the association of melatonin and meloxicam was more effective in protecting animals against the harmful actions of T. cruzi infection as compared with the treatments of meloxicam or melatonin alone...
  17. ncbi From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump
    Stefano Sabatini
    Dipartimento di Chimica e Tecnologia del Farmaco, Universita di Perugia, 06123 Perugia, Italy
    J Med Chem 51:4321-30. 2008
    ..Compounds 6k and 7j displayed good activity against SA-1199B, a strain that also overexpresses norA, in an ethidium bromide (EtBr) efflux inhibition assay...
  18. ncbi Effect of steroidal and non-steroidal anti-inflammatory drugs in combination with long-acting oxytetracycline on non-specific immunity of calves suffering from enzootic bronchopneumonia
    Dariusz Bednarek
    Department of Cattle and Sheep Diseases, National Veterinary Research Institute, Partyzantow 57, 24 100, Pulawy, Poland
    Vet Microbiol 96:53-67. 2003
    ..These results suggest that the combination of meloxicam with an antibiotic in calves suffering from enzootic bronchopneumonia is superior to the antibiotic alone and also to the combination of the antibiotic with flumethasone...
  19. ncbi Evaluation of the influence of meloxicam and flunixin meglumine on the apoptosis of peripheral blood CD4+ and CD8+ T cells in calves
    T Maslanka
    Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Warmia and Mazury, Oczapowskiego 13, 10 718 Olsztyn, Poland
    Pol J Vet Sci 13:3-12. 2010
    ..Our results indicate that the use of meloxicam or flunixin in accordance with the recommended dosage regimen in cattle do not have a clinically significant influence on apoptosis of peripheral blood T cells...
  20. ncbi Comparison of the immunosuppressive effects of dexamethasone, flunixin meglumine and meloxicam on the in vitro response of calf peripheral blood mononuclear cells
    Yousuke Maeda
    School of Veterinary Medicine, Kitasato University, Towada, Aomori 034 8628, Japan
    J Vet Med Sci 73:957-60. 2011
    ..These findings are important for assessing the indications and complications of NSAIDs in calves...
  21. ncbi Enantiomers of 8-(3-tert-butylamino-2-hydroxypropoxy)-3,4-dihydro-3-oxo-2H- (1,4)benzothiazine: racemic resolution, chiral synthesis and biological activity
    F Schiaffella
    Istituto di Chimica Farmaceutica e Technica Farmaceutica, Universita di Perugia, Italy
    Farmaco 45:1299-307. 1990
    ..Compound 1, while confirming the potent beta-blocking activity, displayed a modest enantio-selectivity towards beta 1- and beta 2-adrenoceptors. All the compounds displayed no activity as alpha-adrenoceptor blockers...
  22. ncbi Disposition of sodium salicylate, flunixin and meloxicam after intravenous administration in broiler chickens
    K Baert
    Department of Pharmacology, Pharmacy and Toxicology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium
    J Vet Pharmacol Ther 25:449-53. 2002
    ..Total body clearance was 70 mL/h.kg for sodium salicylate and 10 and 25 mL/kg.h for FLU and MEL, respectively. Based on the pharmacokinetic parameters these NSAIDs may offer possibilities for treatment of various conditions in chickens...
  23. ncbi Analgesic effects of intramuscular administration of meloxicam in Hispaniolan parrots (Amazona ventralis) with experimentally induced arthritis
    Gretchen A Cole
    Department of Surgical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, WI 53706, USA
    Am J Vet Res 70:1471-6. 2009
    ..CONCLUSIONS AND CLINICAL RELEVANCE-Meloxicam administered at 1.0 mg/kg, IM, every 12 hours effectively relieved arthritic pain in parrots...
  24. ncbi VUF-K-8788, a periphery-selective histamine H1 antagonist with anti-pruritic activities
    T Takizawa
    Tokyo Research Laboratories, Pharmaceutical Division, Kowa Company, Ltd, Higashi murayama, Japan
    Jpn J Pharmacol 86:55-64. 2001
    ..These results suggested that VUF-K-8788 would be useful in the treatment of allergic disorders such as atopic dermatitis and eczema...
  25. ncbi The impact of meloxicam on postsurgical stress associated with cautery dehorning
    A Heinrich
    Department of Population Medicine, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
    J Dairy Sci 92:540-7. 2009
    ..1 vs. control: 4 +/- 0.2) were greater in the control group compared with the meloxicam group. These results indicate that meloxicam reduced the physiological stress response to dehorning...
  26. ncbi Spectrophotometric and fluorimetric methods for the determination of meloxicam in dosage forms
    Ekram M Hassan
    Pharmaceutical Analytical Chemistry Department, College of Pharmacy, University of Alexandria, El Messalah 21521, Alexandria, Egypt
    J Pharm Biomed Anal 27:771-7. 2002
    ..The proposed methods were successfully applied to the assay of meloxicam in tablets and suppositories. The procedures were rapid, simple and suitable for quality control applications...
  27. ncbi Determination of meloxicam in bulk and pharmaceutical formulations
    N H Zawilla
    National Organisation of Drug Control and Research, Cairo, Egypt
    J Pharm Biomed Anal 32:1135-44. 2003
    ..The coloured product exhibits an absorption maximum at 455 nm, over concentration range 40-160 microg x ml(-1) with mean percentage accuracy 100.53+/-1.04...
  28. ncbi Effects of local anesthetic and a nonsteroidal antiinflammatory drug on pain responses of dairy calves to hot-iron dehorning
    M Stewart
    AgResearch Ltd, Private Bag 3123, Hamilton 3240, New Zealand
    J Dairy Sci 92:1512-9. 2009
    ..In addition, this study demonstrated that the combination of LA and NSAID mitigated the onset of pain responses when the LA wanes...
  29. ncbi Population pharmacokinetic modelling and simulation of single and multiple dose administration of meloxicam in cats
    T Lehr
    Department of Clinical Pharmacy, Institute of Pharmacy, Freie Universitaet Berlin, Berlin, Germany
    J Vet Pharmacol Ther 33:277-86. 2010
    ..Simulations showed that the median trough steady-state concentrations of 228 ng/mL were reached after five, one or 6 days following a single initial dose of 0.05, 0.1 and 0.2 mg/kg each followed by 0.05 mg/kg/day...
  30. ncbi Meloxicam: a reappraisal of pharmacokinetics, efficacy and safety
    Brian J Gates
    College of Pharmacy, Department of Pharmaceutical Sciences, Washington State University, Pullman, Washington 99164 6534, USA
    Expert Opin Pharmacother 6:2117-40. 2005
    ..The pharmacokinetics of meloxicam enables once daily application, which increases compliance compared with some shorter acting NSAIDs; however, long-term clinical data clearly demonstrating safety and efficacy advantages are lacking...
  31. ncbi The pharmacokinetics of meloxicam in vultures
    V Naidoo
    Department of Paraclinical Sciences, Faculty of Veterinary Science, University of Pretoria, Pretoria, South Africa
    J Vet Pharmacol Ther 31:128-34. 2008
    ..This confirms the safety of repeated exposure to meloxicam in vultures of this genus...
  32. ncbi LC determination and pharmacokinetics of meloxicam
    Bhavesh Dasandi
    Synchron Research Services Pvt Ltd, Sarkhej Gandhinagar Highway, Bodakdev, 380 054, Ahmedabad, India
    J Pharm Biomed Anal 28:999-1004. 2002
    ..The method was simple, specific, precise and accurate. The method was also used for the bioequivalence study of meloxicam formulation in healthy, human, Indian, male volunteers...
  33. ncbi Method development and validation for the analysis of meloxicam in tablets by CZE
    Emirhan Nemutlu
    Department of Analytical Chemistry, Faculty of Pharmacy, University of Hacettepe, 06100 Ankara, Turkey
    J Pharm Biomed Anal 31:393-400. 2003
    ..The relative standard deviation of 7 replicate analyses for each sample was less than 0.66%. The results were compared with a spectrophotometric method reported in literature and no significant difference was found statistically...
  34. ncbi Comparative plasma pharmacokinetics of meloxicam in sheep and goats following intravenous administration
    Manoj Shukla
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243 122 U P India
    Comp Biochem Physiol C Toxicol Pharmacol 145:528-32. 2007
    ..23 microg h mL(-1) and 0.03+/-0.01 L h(-1) kg(-1). The results indicate that elimination kinetics of meloxicam differ significantly between sheep and goats and the elimination of the drug tends to be faster in goats compared to sheep...
  35. ncbi Pharmacokinetic-pharmacodynamic relationships and dose response to meloxicam in horses with induced arthritis in the right carpal joint
    Pierre Louis Toutain
    UMR 181 Physiopathologie et Toxicologie Experimentales, INRA ENVT, Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France
    Am J Vet Res 65:1533-41. 2004
    ..To determine pharmacokinetic-pharmacodynamic (PK-PD) relationships and dose effects for meloxicam in horses and to propose a suitable dosage for use in clinical studies...
  36. ncbi Incretin release from gut is acutely enhanced by sugar but not by sweeteners in vivo
    Yukihiro Fujita
    Department of Cellular and Physiological Sciences, University of British Columbia, Vancouver, BC, Canada V6T 1Z3
    Am J Physiol Endocrinol Metab 296:E473-9. 2009
    ..Collectively, our findings do not support the concept that release of incretins from enteroendocrine cells is triggered by carbohydrates via a pathway identical to the sensation of "sweet taste" in the tongue...
  37. ncbi Risk of serious upper gastrointestinal and cardiovascular thromboembolic complications with meloxicam
    Gurkirpal Singh
    Divisions of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
    Am J Med 117:100-6. 2004
    ..To assess the risk of serious gastrointestinal and thromboembolic complications with approved doses of meloxicam...
  38. ncbi Pharmacokinetics of meloxicam in plasma and urine of horses
    Pierre Louis Toutain
    UMR 181 Physiopathologie et Toxicologie Experimentales, INRA ENVT, Ecole Nationale Veterinaire de Toulouse, 23 Chemin des Capelles, 31076 Toulouse, France
    Am J Vet Res 65:1542-7. 2004
    ..To determine pharmacokinetic parameters for meloxicam, a nonsteroidal anti-inflammatory drug, in horses...
  39. ncbi Pharmacokinetics of intravenous and oral meloxicam in ruminant calves
    Johann F Coetzee
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506, USA
    Vet Ther 10:E1-8. 2009
    ..00 (range, 0.64 to 1.66). These findings indicate that oral meloxicam administration might be an effective and convenient means of providing long-lasting analgesia to ruminant calves...
  40. ncbi Method development and validation for the simultaneous determination of meloxicam and pridinol mesylate using RP-HPLC and its application in drug formulations
    Silvana E Vignaduzzo
    Area Análisis de Medicamentos, Facultad de Ciencias Bioquimicas y Farmaceuticas, Universidad Nacional de Rosario, Suipacha 531, Rosario S2002LRK, Argentina
    J Pharm Biomed Anal 46:219-25. 2008
    ..7 and 1.1 mg l(-1), for meloxicam and pridinol, respectively. The applicability of the method was demonstrated by determining the drug content of two commercial pharmaceutical formulations, where it exhibited good performance...
  41. pmc Corticolimbic transcriptome changes are state-dependent and region-specific in a rodent model of depression and of antidepressant reversal
    Alexandre Surget
    U930 FRE CNRS 2448, INSERM and Université François Rabelais, Tours, France
    Neuropsychopharmacology 34:1363-80. 2009
    ..Correlations between UCMS, drug treatments, and gene expression suggest distinct AMY neuronal and oligodendrocyte molecular phenotypes as candidate systems for mood regulation and therapeutic interventions...
  42. ncbi Clinical pharmacokinetics of meloxicam. A cyclo-oxygenase-2 preferential nonsteroidal anti-inflammatory drug
    N M Davies
    Department of Pharmaceutics, School of Pharmacy, College of Health Sciences, University of Sydney, New South Wales, Australia
    Clin Pharmacokinet 36:115-26. 1999
    ..Drug-drug interaction studies are available for some commonly co-prescribed medications. Concentration-dependent therapeutic and toxicological effects have yet to be extensively elucidated for this NSAID...
  43. ncbi Comparison of analgesic and anti-inflammatory activity of meloxicam gel with diclofenac and piroxicam gels in animal models: pharmacokinetic parameters after topical application
    S K Gupta
    Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India 110 029
    Skin Pharmacol Appl Skin Physiol 15:105-11. 2002
    ..The results indicate that topical preparation of meloxicam could be an effective alternative to diclofenac and piroxicam gels in inflammatory conditions and its associated pain with the possibility of less systemic side-effects...
  44. pmc Role of neonicotinyl insecticides in Washington apple integrated pest management. Part I. Control of lepidopteran pests
    J F Brunner
    Department of Entomology, Tree Fruit Research and Extension Center, Washington State University, 1100 N Western Ave, Wenatchee, Washington, USA
    J Insect Sci 5:14. 2005
    ..The advantages and disadvantages of the neonicotinyl insecticides as replacements for the organophosphate insecticides and their role in a pest management system for Washington apple orchards are discussed...
  45. ncbi Photodynamic therapy of naturally occurring tumors in animals using a novel benzophenothiazine photosensitizer
    A E Frimberger
    The Harrington Oncology Program, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 01536, USA
    Clin Cancer Res 4:2207-18. 1998
    ..5 days) without residual photosensitization. EtNBS-PDT is safe for dogs and cats and has activity against selected naturally occurring tumors, with an overall objective response rate (partial response + CR) of 61.5%...
  46. ncbi Analgesic comparison of meloxicam or ketoprofen for orthopedic surgery in dogs
    Aymeric J Deneuche
    Sections of Surgery and Anesthesia, Ecole Nationale Veterinaire d Alfort, 7 Avenue du Gle De Gaulle, 94704 Maisons Alfort cedex, France
    Vet Surg 33:650-60. 2004
    ..To compare the safety and efficacy of 2 analgesic protocols (preoperative meloxicam or intraoperative ketoprofen administration) during the first 24 hours after orthopedic surgery in dogs...
  47. ncbi ITZ-1, a client-selective Hsp90 inhibitor, efficiently induces heat shock factor 1 activation
    Haruhide Kimura
    Pharmaceutical Research Division, Takeda Pharmaceutical, Osaka, Japan
    Chem Biol 17:18-27. 2010
    ..These results may explain ITZ-1's inhibition of MMP-13 production, its cytoprotective effect, and its lower cytotoxicity. These results suggest that ITZ-1 is a client-selective Hsp90 inhibitor...
  48. ncbi Effects of meloxicam on platelet function in healthy adults: a randomized, double-blind, placebo-controlled trial
    Henry M Rinder
    Department of Laboratory Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8035, USA
    J Clin Pharmacol 42:881-6. 2002
    ..In this study of healthy subjects, meloxicam did not interfere with platelet-mediated hemostasis...
  49. ncbi Evaluation of intravenous administration of meloxicam for perioperative pain management following stifle joint surgery in dogs
    Steven C Budsberg
    Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA
    Am J Vet Res 63:1557-63. 2002
    ..To compare preoperative administration of meloxicam and butorphanol to perioperative administration of butorphanol alone for control of postoperative signs of pain in dogs...
  50. ncbi A pharmacokinetic comparison of meloxicam and ketoprofen following oral administration to healthy dogs
    L Montoya
    Area de Farmacologia, Facultad de Ciencias Veterinarias, Universidad de Buenos Aires, Argentina
    Vet Res Commun 28:415-28. 2004
    ..13 +/- 2.15 h, AUCinf = 15.41 +/- 1.24 microg.h/ml, Vd/F = 0.23 +/- 0.03 L/ kg, and Cl/F = 10 +/- 1.4 ml/(kg.h). Our results indicate significant pharmacokinetic differences between MLX and KTP after therapeutic doses...
  51. pmc Clinical isolates of Mycobacterium tuberculosis in four European hospitals are uniformly susceptible to benzothiazinones
    Maria Rosalia Pasca
    University of Pavia, Department of Genetics and Microbiology, Via Ferrata 1, 27100 Pavia, Italy
    Antimicrob Agents Chemother 54:1616-8. 2010
    ..All 240 strains were susceptible, thus establishing the baseline prior to the introduction of BTZ043 in clinical trials...
  52. ncbi Behavioural effects of ovariohysterectomy and oral administration of meloxicam in laboratory housed rabbits
    Matthew C Leach
    Comparative Biology Centre, Medical School, University of Newcastle, Newcastle upon Tyne NE2 4HH, UK
    Res Vet Sci 87:336-47. 2009
    ..5mg/kg/day) induced some degree of analgesia. However, higher doses of meloxicam or in combination with an opioid may be required to provide consistent analgesia in rabbits following soft-tissue surgery...
  53. ncbi Long-term effects of meloxicam in the treatment of respiratory disease in fattening cattle
    G M Friton
    Corporate Marketing, Boehringer Ingelheim Animal Health, D 55216 Ingelheim am Rhein, Germany
    Vet Rec 156:809-11. 2005
    ..In the animals with lung lesions, significantly less lung tissue was affected in those that had been treated with meloxicam...
  54. ncbi Nonsteroidal antiinflammatory drugs: a review
    Stephen L Curry
    Department of Veterinary Medicine and Surgery and the Comparative Orthopaedic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA
    J Am Anim Hosp Assoc 41:298-309. 2005
    ....
  55. ncbi Pre-emptive meloxicam for postoperative analgesia in piglets undergoing surgical castration
    Alassane Keita
    CTPA, Ploufragan, France
    Vet Anaesth Analg 37:367-74. 2010
    ..To investigate the effect of preoperative meloxicam administration on postoperative stress and pain induced by surgical castration in piglets...
  56. ncbi Biological and structural characterization of the Mycobacterium smegmatis nitroreductase NfnB, and its role in benzothiazinone resistance
    Giulia Manina
    Dipartimento di Genetica e Microbiologia, Universita degli Studi di Pavia, Via Ferrata, 1, 27100 Pavia, Italy
    Mol Microbiol 77:1172-85. 2010
    ..Although Mycobacterium tuberculosis seems to lack nitroreductases able to inactivate these drugs, our findings are valuable for the design of new BTZ molecules, which may be more effective in vivo...
  57. ncbi Pharmacokinetics of oral gabapentin alone or co-administered with meloxicam in ruminant beef calves
    Johann F Coetzee
    Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, Manhattan, KS 66506 5601, USA
    Vet J 190:98-102. 2011
    ..2μg/mL for up to 48h. The pharmacokinetic profile of oral gabapentin and meloxicam supported clinical evaluation of these compounds for management of neuropathic pain in cattle...
  58. ncbi Etodolac inhibits EBER expression and induces Bcl-2-regulated apoptosis in Burkitt's lymphoma cells
    Miki Kobayashi
    Department of Internal Medicine III, Hamamatsu University School of Medicine, Hamamatsu, Japan
    Eur J Haematol 75:212-20. 2005
    ..Moreover, racemate of etodolac more effectively induced apoptosis than R- and/or S-etodolac. Therefore, these activities of etodolac potentially extend to the treatment of patients with Burkitt's lymphoma resistant to chemotherapy...
  59. ncbi Pharmacokinetics of meloxicam in adult goats and its analgesic effect in disbudded kids
    C Ingvast-Larsson
    Division of Pathology, Pharmacology and Toxicology, Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Vet Pharmacol Ther 34:64-9. 2011
    ..Plasma cortisol and glucose concentrations did not differ between the two groups...
  60. ncbi Endocrine, metabolic and clinical effects of intravenous endotoxin injection after pre-treatment with meloxicam in heifers
    K Konigsson
    Department of Obstetrics and Gynaecology, Centre for Reproductive Biology in Uppsala, Swedish University of Agricultural Sciences, Uppsala, Sweden
    J Vet Med A Physiol Pathol Clin Med 49:408-14. 2002
    ..M had no effect on PGF2alpha metabolism. In conclusion, M effectively suppresses several of the inflammatory reactions seen after ET injections and has no major influence on the PGF2alpha metabolism...
  61. ncbi BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression
    Haruhide Kimura
    Pharmaceutical Research Division, Takeda Pharmaceutical Co Ltd, 17 85, Jusohonmachi 2 chome, Yodogawa ku, Osaka 532 8686, Japan
    Chem Biol 17:1282-94. 2010
    ..These results suggest that BTZO-1 activates the GST Ya gene ARE by interacting with MIF...
  62. doi Extralabel use of nonsteroidal anti-inflammatory drugs in cattle
    Geof W Smith
    Food Animal Residue Avoidance Databank, Department of Population Health and Pathobiology, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606, USA
    J Am Vet Med Assoc 232:697-701. 2008
  63. ncbi Effects of neonicotinoid insecticides on the bionomics of twospotted spider mite (Acari: Tetranychidae)
    Mouhoube Ako
    Institute of Plant Diseases and Plant Protection, Hannover University, Herrenhaeuser Str 2, D 30419 Hanover, Germany
    J Econ Entomol 97:1587-94. 2004
    ..urticae. These findings are discussed with regard to previous laboratory and field observations of imidacloprid-induced fertility increases in T. urticae...
  64. ncbi Investigation on the clinical efficacy and safety of meloxicam (Metacam) in the treatment of non-infectious locomotor disorders in pigs
    Gabriele M Friton
    Boehringer Ingelheim Animal Health GmbH, Corporate Marketing, Ingelheim am Rhein, Germany
    Berl Munch Tierarztl Wochenschr 116:421-6. 2003
    ..It is concluded that intramuscular injection of meloxicam (Metacam) at a dosage of 0.4 mg/kg is efficacious and safe for the treatment of non-infectious locomotor disorders in pigs...
  65. pmc Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2
    Oliver J Mace
    Department of Biology Area 3, University of York, York YO10 5YW, UK
    J Physiol 582:379-92. 2007
    ....
  66. ncbi The effect of meloxicam, a selective COX-2 inhibitor, on the microvasculature of small metastatic liver tumors in rats
    Naoko Iwase
    Department of Surgical Oncology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Jpn J Clin Oncol 37:673-8. 2007
    ..In this study, we investigated the tumor vessels of small metastatic liver tumors in rats and the effect of meloxicam, a selective COX-2 inhibitor, on their growth and microvasculature...
  67. ncbi The non-steroidal anti-inflammatory drugs protect mouse cochlea against acoustic injury
    Tomofumi Hoshino
    Department of Otolaryngology, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Tohoku J Exp Med 216:53-9. 2008
    ..In contrast, COX-2 inhibitors, meloxicam, SC58125, and CAY10404, showed no noticeable effects on the ABR threshold shifts. These findings suggest that COX-1 and LOX are involved in the pathogenesis of acoustic injury in cochlea...
  68. ncbi In vitro studies of a degradable device for controlled-release of meloxicam
    Emel O Cetin
    Department of Biopharmaceutics and Pharmacokinetics, School of Pharmacy, Ege University, Izmir, Turkey
    J Clin Periodontol 32:773-7. 2005
    ....
  69. ncbi Synergistic anti-inflammatory interaction between meloxicam and aminoguanidine hydrochloride in carrageenan-induced acute inflammation in rats
    Shailesh P Dudhgaonkar
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, U P 243 122 India
    Life Sci 78:1044-8. 2006
    ..These results suggest that co-administration of meloxicam and aminoguanidine hydrochloride may be an alternative in clinical control of inflammation...
  70. ncbi No effect of ketoprofen and meloxicam on bone graft ingrowth: a bone chamber study in goats
    Huub J L van der Heide
    Department of Orthopedics, Orthopedic Research Laboratory, Nijmegen Medical Center, Radboud University, Nijmegen, The Netherlands
    Acta Orthop 79:548-54. 2008
    ..We studied the effect of two different NSAIDs on bone and tissue ingrowth in a bone chamber model in goats, using autograft, rinsed allograft, and allograft that had been rinsed and subsequently irradiated...
  71. ncbi Synergistic interaction between meloxicam and aminoguanidine in formalin-induced nociception in mice
    Shailesh P Dudhgaonkar
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar, 243122 Uttar Pradesh, India
    Eur J Pain 12:321-8. 2008
    ....
  72. ncbi The interaction between orally administered non-steroidal anti-inflammatory drugs and prednisolone in healthy dogs
    Tatsuya Narita
    Department of Clinical Veterinary Science, The United Graduate School of Veterinary Sciences, Gifu University, Japan
    J Vet Med Sci 69:353-63. 2007
    ....
  73. ncbi Renal effect of meloxicam versus ketoprofen in anaesthetized pseudo-normovolaemic piglets
    Stéphane Junot
    Ecole Nationale Veterinaire de Lyon, EA 4173, INSERM ESPRI ERI 22, Marcy l Etoile, France
    Can J Physiol Pharmacol 86:55-63. 2008
    ..This study demonstrates the safety of meloxicam for preemptive surgical analgesia under conditions of normovolaemia. Fluid therapy appears recommended to prevent any renal dysfunction...
  74. ncbi The clinical pharmacology of cyclooxygenase-2-selective and dual inhibitors
    Terrence P Clark
    Department of Biology Research and Technology Acquisitions, Elanco Animal Health, A Division of Eli Lilly and Company, 2001 West Main Street, GL14, Greenfield, IN 46140, USA
    Vet Clin North Am Small Anim Pract 36:1061-85, vii. 2006
    ..Until head-to-head trials in multicenter blind studies are published, comments on comparative safety and effectiveness must be reserved...
  75. ncbi Extent of renal effect of cyclo-oxygenase-2-selective inhibitors is pharmacokinetic dependent
    Sam Harirforoosh
    Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, Alberta, Canada
    Clin Exp Pharmacol Physiol 33:917-24. 2006
    ..The relatively higher distribution into the kidneys of rofecoxib and celecoxib compared with meloxicam suggests involvement of direct drug exposure in the kidneys in the adverse renal effect...
  76. ncbi Premedication with cyclooxygenase-2 inhibitor meloxicam reduced postoperative pain in patients after oral surgery
    T Aoki
    Department of Oral and Maxillofacial Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo, Japan
    Int J Oral Maxillofac Surg 35:613-7. 2006
    ..01). Total analgesic consumption was significantly lower in groups A and B than in group C (P<0.02). The COX-2 inhibitor, meloxicam 10 mg used for premedication reduced postoperative pain compared with control in oral surgery...
  77. ncbi Safety of meloxicam in aspirin-hypersensitive patients with asthma and/or nasal polyps. A challenge-proven study
    Sevim Bavbek
    Department of Allergic Diseases, Ankara University School of Medicine, Ankara, Turkey
    Int Arch Allergy Immunol 142:64-9. 2007
    ..Therefore, a new class of drugs with COX-2 selectivity may be well tolerated by patients with ASA/NSAIDs hypersensitivity...
  78. ncbi Selective COX-2 inhibitor reduces bone healing in bone defects
    Bruno César de Vasconcelos Gurgel
    Division of Periodontics, Department of Prosthodontics and Periodontics, School of Dentistry at Piracicaba, State University of Campinas
    Braz Oral Res 19:312-6. 2005
    ..75%, against group D, 52.25 +/- 17.25%). Within the limits of the present study, it can be concluded that selective cyclooxygenase-2 inhibitors may reduce bone healing in calvarial defects in rats after continuous administration...
  79. ncbi The effects of a COX-2 inhibitor meloxicam on squamous cell carcinoma of the esophagus in vivo
    Jun Feng Liu
    Department of Thoracic Surgery, Fourth Hospital, Hebei Medical University, Shijiazhuang, China
    Int J Cancer 122:1639-44. 2008
    ..We conclude that meloxicam induces apoptosis in SCC of the esophagus in vivo by inhibiting the pathway of NF-kappaB downstream regulation of COX-2...
  80. ncbi Preparation and evaluation of solid dispersion of meloxicam with skimmed milk
    Sengodan Gurusamy Vijaya Kumar
    Department of Pharmaceutical Sciences, Guru Jambheshwar University, Haryana, India
    Yakugaku Zasshi 126:93-7. 2006
    ..Differential scanning calorimetry, X-ray diffraction and scanning electron microscopic analysis revealed the formation of solid dispersion of the drug with skimmed milk...
  81. ncbi Safety of selective cyclooxygenase-2 inhibitors and a basic non-steroidal anti-inflammatory drug (NSAID) in Japanese patients with NSAID-induced urticaria and/or angioedema: Comparison of meloxicam, etodolac and tiaramide
    Naoko Inomata
    Department of Dermatology, Yokohama City University Hospital, Fukuura, Yokohama, Japan
    J Dermatol 34:172-7. 2007
    ..Furthermore, meloxicam seems to be better tolerated than etodolac between two selective COX-2 inhibitors...
  82. ncbi Sulindac induces specific degradation of the HPV oncoprotein E7 and causes growth arrest and apoptosis in cervical carcinoma cells
    Theresia Karl
    Deutsches Krebsforschungszentrum, Forschungsschwerpunkt Angewandte Tumorvirologie, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
    Cancer Lett 245:103-11. 2007
    ..These results support the notion that sulindac is a potent growth inhibitor and inducer of apoptosis on cervical cancer cells in vitro and may offer new perspectives as a chemopreventive or supplementary anti-cervical cancer drug...
  83. ncbi Tolerability to nabumetone and meloxicam in patients with nonsteroidal anti-inflammatory drug intolerance
    Alicia Prieto
    Allergy Service, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    J Allergy Clin Immunol 119:960-4. 2007
    ..Because nonsteroidal anti-inflammatory drug (NSAID) intolerance depends on COX-1 inhibition, preferential or selective COX-2 inhibitors have been thought to be well tolerated by these patients...
  84. ncbi Effects of an ophthalmic formulation of meloxicam on COX-2 expression, PGE2 release, and cytokine expression in a model of acute ocular inflammation
    R Cruz
    Sección Externa de Toxicología, CINVESTAV, Av IPN 2508, San Pedro Zacatenco, Mexico DF, 07360, Mexico
    Br J Ophthalmol 92:120-5. 2008
    ..To determine the efficacy of meloxicam ophthalmic formulation on COX-2 activity and expression, inflammation-related cytokines expression and inflammation in an ocular inflammation model...
  85. ncbi Long-term safety, efficacy and palatability of oral meloxicam at 0.01-0.03 mg/kg for treatment of osteoarthritic pain in cats
    Marcus N Gunew
    The Cat Clinic Mt Gravatt, Mt Gravatt, QLD, Australia
    J Feline Med Surg 10:235-41. 2008
    ..The results of this study showed oral meloxicam to be safe and palatable long-term treatment for osteoarthritis in cats when given with food at a dose of 0.01-0.03 mg/kg...
  86. ncbi Comparison of intramuscular and oral meloxicam in rheumatoid arthritis patients
    B Combe
    , H pital Lapeyronie 371, Montpellier, France
    Inflamm Res 50:S10-6. 2001
    ..CONCLUSION: Oral and im meloxicam (15 mg) were both effective and well-tolerated for acute exacerbations of RA. The im formulation had some advantages, such as a faster onset of action...
  87. ncbi Anti-inflammatory effect and low ulcerogenic activity of etodolac, a cyclooxygenase-2 selective non-steroidal anti-inflammatory drug, on adjuvant-induced arthritis in rats
    Masaki Tachibana
    Research Laboratories, Nippon Shinyaku Co, Ltd, Kyoto, Japan
    Pharmacology 68:96-104. 2003
    ....
  88. ncbi Comparison of the incidence rates of selected gastrointestinal events reported for patients prescribed rofecoxib and meloxicam in general practice in England using prescription-event monitoring data
    D Layton
    Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, UK
    Rheumatology (Oxford) 42:622-31. 2003
    ....
  89. ncbi Do selective cyclo-oxygenase inhibitors eliminate the adverse events associated with nonsteroidal anti-inflammatory drug therapy?
    Jacques Deviere
    Department of Gastroenterology, University Hospital Erasme, Route de Lennik 808, Brussels 1070, Belgium
    Eur J Gastroenterol Hepatol 14:S29-33. 2002
    ..Finally, case reports and the results of animal experiments suggest that COX-2 inhibitors may adversely affect ovulation and cause a tendency towards prothrombotic events...
  90. ncbi Review article: NSAIDs, gastroprotection and cyclo-oxygenase-II-selective inhibitors
    R Micklewright
    National Prescribing Centre, Liverpool, UK
    Aliment Pharmacol Ther 17:321-32. 2003
    ..The gastrointestinal safety of meloxicam and etodolac has not been adequately assessed in such trials. Therefore, evidence for their use instead of non-selective NSAIDs, or instead of celecoxib or rofecoxib, is not robust...
  91. ncbi Prophylaxis of heterotopic ossification after total hip arthroplasty: a prospective randomized study comparing indomethacin and meloxicam
    Thomas Barthel
    Department of Orthopaedic Surgery, König Ludwig Haus, Julius Maximilians University, DE 97074 Würzburg, Germany
    Acta Orthop Scand 73:611-4. 2002
    ....
  92. pmc Modulation of cell recruitment by anti-inflammatory agents in antigen-induced arthritis
    M J Lopez-Armada
    Inflammation Research Unit, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Ann Rheum Dis 61:1027-30. 2002
    ..To study the effect of meloxicam (MXC) and diclofenac (DCF) on the recruitment of leucocytes during acute experimental arthritis...
  93. pmc A comparison of the effects of nabumetone vs meloxicam on serum thromboxane B2 and platelet function in healthy volunteers
    D J W van Kraaij
    Department of Cardiology, Academic Hospital Maastricht, Maastricht, The Netherlands
    Br J Clin Pharmacol 53:644-7. 2002
    ..To compare the effects of nabumetone and meloxicam, two cyclo-oxygenase-2 (COX-2) preferential nonsteroidal anti-inflammatory drugs (NSAIDs), on platelet COX-1 activity and platelet function...
  94. ncbi High response rate in the phase I/II study of meloxicam in juvenile rheumatoid arthritis
    Ivan Foeldvari
    Pediatric Rheumatology Clinic, Am Allgemeinen Krankenhaus Eilbek, Hamburg, Germany
    J Rheumatol 29:1079-83. 2002
    ..In this 12 week Phase I/II study, with an additional open extension lasting up to 52 weeks, the safety, efficacy, and pharmacokinetics of meloxicam in JRA were investigated...
  95. pmc Cyclooxygenase inhibition: between the devil and the deep blue sea
    C J Hawkey
    Queen s Medical Centre, University Hospital, Nottingham, UK
    Gut 50:III25-30. 2002
    ..Between them, aspirin and non-aspirin NSAIDs may account for more than half of all episodes of ulcer bleeding and perforation...
  96. ncbi New cyclooxygenase-2 inhibitors for treatment of experimental autoimmune neuritis
    Katsuichi Miyamoto
    Department of Immunology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Tokyo 187 8502, Japan
    Muscle Nerve 25:280-2. 2002
    ..These findings suggest that the new COX-2 inhibitors may be useful as additional therapeutic agents for patients with Guillain-Barré syndrome and chronic inflammatory demyelinating polyneuropathy...
  97. ncbi Nonsteroidal anti-inflammatory drugs prevent early diabetic retinopathy via TNF-alpha suppression
    Antonia M Joussen
    Retina Research Laboratory, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts 02114, USA
    FASEB J 16:438-40. 2002
    ..Taken together, these data identify COX-2 and TNF-alpha as operative in the early signature pathologies of diabetic retinopathy, a newly recognized inflammatory disease...
  98. pmc Acute gastrointestinal permeability responses to different non-steroidal anti-inflammatory drugs
    E Smecuol
    Small Intestinal Section, Clinical Service, C Bonorino Udaondo Gastroenterology Hospital, Del Salvador University, Buenos Aires, Argentina
    Gut 49:650-5. 2001
    ..However, most produced significant alteration of small intestinal permeability. In contrast, our results suggest that celecoxib seems to exhibit the most desirable gastrointestinal side effect profile...
  99. ncbi Efficacy assessment of meloxicam, a preferential cyclooxygenase-2 inhibitor, in acute coronary syndromes without ST-segment elevation: the Nonsteroidal Anti-Inflammatory Drugs in Unstable Angina Treatment-2 (NUT-2) pilot study
    Raul Altman
    Centro de Trombosis de Buenos Aires, Catedra de Magister en Trombosis, Facultad de Medicina de Tucuman, Buenos Aires, Argentina
    Circulation 106:191-5. 2002
    ....
  100. ncbi Classic NSAID and selective cyclooxygenase (COX)-1 and COX-2 inhibitors in healing of chronic gastric ulcers
    T Brzozowski
    Department of Physiology Jagellonian University School of Medicine, Cracow, Poland
    Microsc Res Tech 53:343-53. 2001
    ....
  101. ncbi Meloxicam oral suspension: a treatment alternative to solid meloxicam formulations
    G Hanft
    Department of Clinical Research, Boehringer Ingelheim Pharma KG, Biberach/Riss, Germany
    Inflamm Res 50:S35-7. 2001
    ..The oral suspension was well accepted by the patients. Hence, the oral suspension provides a useful alternative to solid formulations in the treatment of inflammatory joint diseases and painful musculoskeletal disorders...

Research Grants9

  1. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..abstract_text> ..
  2. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  3. REGULATION OF INTRAOCULAR PRESSURE AND OCULAR BLOOD FLOW
    John Liu; Fiscal Year: 2007
    ..New knowledge of ocular blood flow and lOP in patients would have implications for the better diagnosis and treatment of glaucoma. ..
  4. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  5. Bioreactor Expansion and Transplantation of ES Cell Derived Osteoblasts and Chond
    John Matyas; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  6. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  7. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  8. GENETICS OF ALCOHOL RELATED INGESTIVE BEHAVIORS IN MICE
    Alexander Bachmanov; Fiscal Year: 2007
    ..Through these three aims, we intend to isolate loci involved in ethanol preference, identify candidate genes for these loci in mice, and specify their human orthologs. ..
  9. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..