alkanesulfonic acids

Summary

Summary: Sulfonic acid derivatives that are substituted with an aliphatic hydrocarbon group.

Top Publications

  1. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
  2. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
  3. pmc Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population
    Jessica W Nelson
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:197-202. 2010
  4. pmc Neuroendocrine effects of perfluorooctane sulfonate in rats
    Maureen E Austin
    Neuroendocrine Research Laboratory, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Center, Michigan State University, East Lansing, MI 48824, USA
    Environ Health Perspect 111:1485-9. 2003
  5. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
  6. ncbi Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X rec
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, USA
    Toxicol Sci 92:476-89. 2006
  7. ncbi Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, United States
    Environ Sci Technol 46:6330-8. 2012
  8. pmc Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 116:1391-5. 2008
  9. ncbi Exposure to perfluorinated compounds and human semen quality in Arctic and European populations
    G Toft
    Department of Occupational Medicine, Danish Ramazzini Center, Aarhus University Hospital, Norrebrogade 44, Building 2C, Aarhus C 8000, Denmark
    Hum Reprod 27:2532-40. 2012
  10. pmc Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, 1 Medical Center Drive, Morgantown, WV 26506 9105, USA
    Arch Pediatr Adolesc Med 164:860-9. 2010

Research Grants

  1. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
  2. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
  3. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
  4. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
  5. Distribution of PCB Atropisomers
    Hans Joachim Lehmler; Fiscal Year: 2008
  6. Perfluorocarbon Materials As Drug Delivery Vehicles
    Hans Joachim Lehmler; Fiscal Year: 2004
  7. IRON, ZINC AND FOLATE AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2001
  8. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
  9. Epidemiologic Evaluation of Perfluorooctyl Compounds
    James Raymer; Fiscal Year: 2003
  10. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009

Detail Information

Publications231 found, 100 shown here

  1. pmc Half-life of serum elimination of perfluorooctanesulfonate,perfluorohexanesulfonate, and perfluorooctanoate in retired fluorochemical production workers
    Geary W Olsen
    Medical Department, 3M Company, St Paul, Minnesota 55144, USA
    Environ Health Perspect 115:1298-305. 2007
    ..The presence of perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHS), and perfluorooctanoate (PFOA) has been reported in humans and wildlife. Pharmacokinetic differences have been observed in laboratory animals...
  2. pmc The applicability of biomonitoring data for perfluorooctanesulfonate to the environmental public health continuum
    John L Butenhoff
    3M Company, Medical Department, St Paul, Minnesota 55144, USA
    Environ Health Perspect 114:1776-82. 2006
    ....
  3. pmc Exposure to polyfluoroalkyl chemicals and cholesterol, body weight, and insulin resistance in the general U.S. population
    Jessica W Nelson
    Department of Environmental Health, Boston University School of Public Health, Boston, Massachusetts 02118, USA
    Environ Health Perspect 118:197-202. 2010
    ..Polyfluoroalkyl chemicals (PFCs) are used commonly in commercial applications and are detected in humans and the environment worldwide. Concern has been raised that they may disrupt lipid and weight regulation...
  4. pmc Neuroendocrine effects of perfluorooctane sulfonate in rats
    Maureen E Austin
    Neuroendocrine Research Laboratory, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine Center, Michigan State University, East Lansing, MI 48824, USA
    Environ Health Perspect 111:1485-9. 2003
    ..PFOS treatment also increased norepinephrine concentrations in the paraventricular nucleus of the hypothalamus. These results indicate that exposure to PFOS can affect the neuroendocrine system in rats...
  5. pmc Partition of environmental chemicals between maternal and fetal blood and tissues
    Larry L Needham
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Environ Sci Technol 45:1121-6. 2011
    ..Although the environmental chemicals examined pass through the placenta and are excreted into milk, partitions between maternal and fetal samples are not uniform...
  6. ncbi Differential activation of nuclear receptors by perfluorinated fatty acid analogs and natural fatty acids: a comparison of human, mouse, and rat peroxisome proliferator-activated receptor-alpha, -beta, and -gamma, liver X receptor-beta, and retinoid X rec
    John P Vanden Heuvel
    Department of Veterinary and Biomedical Science and The Center for Molecular Toxicology and Carcinogenesis, The Pennsylvania State University, University Park, 16802, USA
    Toxicol Sci 92:476-89. 2006
    ..Compared to naturally occurring long-chain fatty acids, e.g. linoleic and alpha-linolenic acids, these perfluorinated fatty acid analogs were more selective and less potent in their activation of the NRs...
  7. ncbi Temporal trends of perfluoroalkyl concentrations in American Red Cross adult blood donors, 2000-2010
    Geary W Olsen
    3M Company, Medical Department, St Paul, Minnesota, United States
    Environ Sci Technol 46:6330-8. 2012
    ..8 years reported in individuals. This similarity supports the conclusion that the dominant PFOS-related exposures to humans in the United States were greatly mitigated during the phase-out period...
  8. pmc Prenatal exposure to perfluorooctanoate (PFOA) and perfluorooctanesulfonate (PFOS) and maternally reported developmental milestones in infancy
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 116:1391-5. 2008
    ..Animal studies have shown that they may affect neuromuscular development at high concentrations...
  9. ncbi Exposure to perfluorinated compounds and human semen quality in Arctic and European populations
    G Toft
    Department of Occupational Medicine, Danish Ramazzini Center, Aarhus University Hospital, Norrebrogade 44, Building 2C, Aarhus C 8000, Denmark
    Hum Reprod 27:2532-40. 2012
    ..Perfluorinated compounds (PFCs) have been suspected to adversely affect human reproductive health. The aim of this study was to investigate the associations between PFC exposure and male semen quality...
  10. pmc Perfluorooctanoic acid, perfluorooctanesulfonate, and serum lipids in children and adolescents: results from the C8 Health Project
    Stephanie J Frisbee
    Department of Community Medicine, West Virginia University School of Medicine, Robert C Byrd Health Sciences Center, 1 Medical Center Drive, Morgantown, WV 26506 9105, USA
    Arch Pediatr Adolesc Med 164:860-9. 2010
    ..Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) are man-made compounds with widespread presence in human sera. In previous occupational and adult studies, PFOA and PFOS were positively associated with serum lipid levels...
  11. ncbi Perfluorinated compounds in maternal serum and cord blood from selected areas of South Africa: results of a pilot study
    Linda Hanssen
    Department of Community Medicine, University of Tromsø, 9037 Tromsø, Norway
    J Environ Monit 12:1355-61. 2010
    ..Possible exposure pathways could be different from those elucidated in the western world with the exception of the urban community in our study that showed higher living standards in general and easier access to modern consumer products...
  12. ncbi Neonatal exposure to PFOS and PFOA in mice results in changes in proteins which are important for neuronal growth and synaptogenesis in the developing brain
    Niclas Johansson
    Department of Environmental Toxicology, Uppsala University, Uppsala, Sweden
    Toxicol Sci 108:412-8. 2009
    ..These proteins are important for normal brain development, and altered levels of these proteins during a critical period of the brain growth spurts could be one of the mechanisms behind earlier reported behavioral defects...
  13. ncbi Pre- and postnatal exposure to perfluorinated compounds (PFCs)
    Hermann Fromme
    Department of Chemical Safety and Toxicology Biomonitoring, Bavarian Health and Food Safety Authority, Pfarrstrasse 3, D 80538 Munich, Germany
    Environ Sci Technol 44:7123-9. 2010
    ..Although the concentrations in breast milk were low, this intake led to a body burden at the age of six months similar to (PFOS) or higher than (PFOA) that found in adults...
  14. pmc Correlations between prenatal exposure to perfluorinated chemicals and reduced fetal growth
    Noriaki Washino
    Department of Public Health, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Environ Health Perspect 117:660-7. 2009
    ..Although recent studies have shown that these chemicals interfere with fetal growth in humans, the results are inconsistent...
  15. pmc Polyfluoroalkyl chemicals in the U.S. population: data from the National Health and Nutrition Examination Survey (NHANES) 2003-2004 and comparisons with NHANES 1999-2000
    Antonia M Calafat
    Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
    Environ Health Perspect 115:1596-602. 2007
    ..Exposure of the general U.S. population to PFCs is widespread. Since 2002, the manufacturing practices for PFCs in the United States have changed considerably...
  16. pmc Perfluorooctane sulfonate (PFOS) induces reactive oxygen species (ROS) production in human microvascular endothelial cells: role in endothelial permeability
    Yong Qian
    Pathology and Physiology Research Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505 2888, USA
    J Toxicol Environ Health A 73:819-36. 2010
    ..The results generated from this study may provide a new insight into the potential adverse effects of PFOS exposure on humans at the cellular level...
  17. ncbi Distribution of perfluorochemicals between sera and milk from the same mothers and implications for prenatal and postnatal exposures
    Seung Kyu Kim
    School of Earth and Environmental Sciences BK 21, Seoul National University, Kwanakgu Shilimdong san 56 1, Seoul 151 742, Republic of Korea
    Environ Pollut 159:169-74. 2011
    ..Accordingly, compound- and matrix-specific transfer must be considered when assessing prenatal and postnatal exposure...
  18. ncbi Developmental toxicity and alteration of gene expression in zebrafish embryos exposed to PFOS
    Xiongjie Shi
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China
    Toxicol Appl Pharmacol 230:23-32. 2008
    ....
  19. ncbi Perfluorooctanoate and perfluorooctanesulfonate plasma levels and risk of cancer in the general Danish population
    Kirsten T Eriksen
    Institute of Cancer Epidemiology, Danish Cancer Society, Strandboulevarden 49, Copenhagen Ø, Denmark
    J Natl Cancer Inst 101:605-9. 2009
    ..99 to 1.93). Plasma concentrations of perfluorooctanoate and perfluorooctanesulfonate in the general Danish population appear not to be associated with risk of prostate, bladder, pancreatic, or liver cancer...
  20. ncbi Perfluoroalkyl chemicals and human fetal development: an epidemiologic review with clinical and toxicological perspectives
    Geary W Olsen
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:212-30. 2009
    ..Important issues are addressed regarding the methods and data analysis that may limit inferences from this particular study...
  21. ncbi Studies on the toxicological effects of PFOA and PFOS on rats using histological observation and chemical analysis
    Lin Cui
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Arch Environ Contam Toxicol 56:338-49. 2009
    ..The definite toxicity and high accumulation of the tested PFCs might pose a great threat to biota and human beings due to their widespread application in various fields...
  22. ncbi Association of perfluorooctanoic acid and perfluorooctane sulfonate with serum lipids among adults living near a chemical plant
    Kyle Steenland
    Department of Environmental and Occupational Health, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 170:1268-78. 2009
    ..Because these data are cross-sectional, causal inference is limited. Nonetheless, the associations between these compounds and lipids raise concerns, given their common presence in the general population...
  23. ncbi Sonochemical decomposition of perfluorooctane sulfonate and perfluorooctanoic acid
    Hiroshi Moriwaki
    Osaka City Institute of Public Health and Environmental Sciences, 8 34, Tojo cho, Tennoji ku, Osaka 543 0026, Japan
    Environ Sci Technol 39:3388-92. 2005
    ....
  24. pmc Association between serum perfluorooctanoic acid (PFOA) and thyroid disease in the U.S. National Health and Nutrition Examination Survey
    David Melzer
    Epidemiology and Public Health Group, eninsula Medical School, Exeter, United Kingdom
    Environ Health Perspect 118:686-92. 2010
    ..Their persistence in the environment plus toxicity in animal models has raised concern over low-level chronic exposure effects on human health...
  25. ncbi Partial life-cycle toxicity and bioconcentration modeling of perfluorooctanesulfonate in the northern leopard frog (Rana pipiens)
    Gerald T Ankley
    US Environmental Protection Agency, Office of Research and Development, National Health and Environmental Effects Research Laboratory, Mid Continent Ecology Division, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 23:2745-55. 2004
    ..Overall, our studies suggest that R. pipiens is not exceptionally sensitive to PFOS in terms of either direct toxicity or bioconcentration potential of the chemical...
  26. ncbi Perfluorooctane sulfonate impairs the cardiac development of a marine medaka (Oryzias melastigma)
    Qiansheng Huang
    Institute of Urban Environment, Chinese Academy of Sciences, Xiamen 361021, PR China
    Aquat Toxicol 105:71-7. 2011
    ..Our results showed for the first time that PFOS exposure affected the expression of cardiac development-related genes, development and function of heart in the marine medaka...
  27. ncbi Determinants of fetal exposure to polyfluoroalkyl compounds in Baltimore, Maryland
    Benjamin J Apelberg
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland 21205, USA
    Environ Sci Technol 41:3891-7. 2007
    ..Our findings suggest that in utero exposure to PFOS and PFOA is ubiquitous in a population of babies born in Baltimore, MD...
  28. ncbi Prenatal PFOS exposure induces oxidative stress and apoptosis in the lung of rat off-spring
    Tian Chen
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Reprod Toxicol 33:538-45. 2012
    ..The results indicate that oxidative stress and both intrinsic and extrinsic cell death pathways were involved in prenatal PFOS exposure-induced injuries in postnatal lungs...
  29. ncbi Alterations in cell membrane properties caused by perfluorinated compounds
    Wen yue Hu
    National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, MI 48824, USA
    Comp Biochem Physiol C Toxicol Pharmacol 135:77-88. 2003
    ..This suggests that PFOS effects membrane properties at concentrations below those associated with other adverse effects...
  30. ncbi Perfluorooctane sulfonate induces apoptosis of cerebellar granule cells via a ROS-dependent protein kinase C signaling pathway
    Hyun Gyo Lee
    Department of Pharmacology and Toxicology, School of Medicine, Catholic University of Daegu, Daegu, South Korea
    Neurotoxicology 33:314-20. 2012
    ..Thus, this study may contribute to understand a new mechanistic aspect of PFOS-induced neurotoxicities...
  31. ncbi Umbilical cord blood levels of perfluoroalkyl acids and polybrominated flame retardants
    Tye E Arbuckle
    Population Studies Division, Healthy Environments and Consumer Safety Branch, Health Canada, Canada
    Int J Hyg Environ Health 216:184-94. 2013
    ..Similar to reports from other countries, the preponderant PBDE congener measured in the cord blood was PBDE-47. Questions remain on why various studies have reported conflicting results on the association between PFAAs and birth weight...
  32. ncbi Perfluorooctanoate, perflourooctanesulfonate, and N-ethyl perfluorooctanesulfonamido ethanol; peroxisome proliferation and mitochondrial biogenesis
    Jessica Berthiaume
    Department of Biochemistry and Molecular Biology, Toxicology Graduate Program, University of Minnesota School of Medicine, 10 University Drive, Duluth, MN 55812 2496, USA
    Toxicol Lett 129:23-32. 2002
    ..These data demonstrate that acute administration of PFOS or PFOA causes hepatic peroxisome proliferation in rats. However, stimulation of mt biogenesis is not a characteristic response of all peroxisome proliferators...
  33. ncbi Determinants of plasma PFOA and PFOS levels among 652 Danish men
    Kirsten T Eriksen
    Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen, Denmark
    Environ Sci Technol 45:8137-43. 2011
    ..Our finding of a higher body burden of PFOA and PFOS among never smokers also warrants further evaluation...
  34. ncbi Activation of mouse and human peroxisome proliferator-activated receptors (alpha, beta/delta, gamma) by perfluorooctanoic acid and perfluorooctane sulfonate
    Margy L Takacs
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, North Carolina 27711, USA
    Toxicol Sci 95:108-17. 2007
    ....
  35. ncbi Multiplicity of nuclear receptor activation by PFOA and PFOS in primary human and rodent hepatocytes
    J A Bjork
    Department of Biochemistry and Molecular Biology, University of Minnesota Medical School, Duluth, MN, USA
    Toxicology 288:8-17. 2011
    ....
  36. ncbi Maternal exposure to perfluorinated acids and fetal growth
    Michele P Hamm
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    J Expo Sci Environ Epidemiol 20:589-97. 2010
    ..These results suggest that maternal PFA exposure has no substantial effect on fetal weight and length of gestation at the concentrations observed in this population...
  37. ncbi Neonatal exposure to perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) causes neurobehavioural defects in adult mice
    N Johansson
    Department of Environmental Toxicology, Uppsala University, Norbyvägen 18 A, S 752 36 Uppsala, Sweden
    Neurotoxicology 29:160-9. 2008
    ..These developmental neurotoxic effects are similar to those we reported earlier for PCBs and PBDEs. This suggests that PFOS and PFOA be included in the group of POPs known to be developmental neurotoxicants...
  38. pmc Association of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) with uric acid among adults with elevated community exposure to PFOA
    Kyle Steenland
    Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Health Perspect 118:229-33. 2010
    ..PFOA has been associated with elevated uric acid in two studies of chemical workers. Uric acid is a risk factor for hypertension and possibly other cardiovascular outcomes...
  39. pmc Relationships of perfluorooctanoate and perfluorooctane sulfonate serum concentrations between mother-child pairs in a population with perfluorooctanoate exposure from drinking water
    Debapriya Mondal
    London School of Hygiene and Tropical Medicine, London, United Kingdom
    Environ Health Perspect 120:752-7. 2012
    ..This study provides an opportunity to assess the association between PFAA concentrations in mother-child pairs in a population exposed to PFOA via drinking water...
  40. pmc Developmental neurotoxicity of perfluorinated chemicals modeled in vitro
    Theodore A Slotkin
    Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Environ Health Perspect 116:716-22. 2008
    ..The widespread detection of perfluoroalkyl acids and their derivatives in wildlife and humans, and their entry into the immature brain, raise increasing concern about whether these agents might be developmental neurotoxicants...
  41. ncbi Behavioral effects in adult mice exposed to perfluorooctane sulfonate (PFOS)
    Silvia Fuentes
    Department of Psychology, Psychobiology Unit, Rovira i Virgili University, Sescelades Campus, 43007, Tarragona, Spain
    Toxicology 242:123-9. 2007
    ..In the retention test, a deleterious effect of PFOS was noted. These results indicate that PFOS exposure induced only slight behavioral effects in adult male mice...
  42. ncbi Maternal levels of perfluorinated chemicals and subfecundity
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, University of California Los Angeles, PO Box 951772, 71 254 CHS, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Hum Reprod 24:1200-5. 2009
    ..Perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) are ubiquitous man-made compounds that are possible hormonal disruptors. We examined whether exposure to these compounds may decrease fecundity in humans...
  43. pmc Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults
    Chien Yu Lin
    Department of Internal Medicine of Nephrology, En Chu Kong Hospital, Taipei County, Taiwan
    Diabetes Care 32:702-7. 2009
    ..Perfluoroalkyl chemicals (PFCs) have been used worldwide in a variety of consumer products. The effect of PFCs on glucose homeostasis is not known...
  44. ncbi Reproductive and developmental toxicity and bioconcentration of perfluorooctanesulfonate in a partial life-cycle test with the fathead minnow (Pimephales promelas)
    Gerald T Ankley
    Mid Continent Ecology Division, National Health and Environmental Effects Research Laboratory, U S Environmental Protection Agency, 6201 Congdon Boulevard, Duluth, Minnesota 55804, USA
    Environ Toxicol Chem 24:2316-24. 2005
    ....
  45. pmc Chronic PFOS exposures induce life stage-specific behavioral deficits in adult zebrafish and produce malformation and behavioral deficits in F1 offspring
    Jiangfei Chen
    Wenzhou Medical College, Wenzhou, Zhejiang, China
    Environ Toxicol Chem 32:201-6. 2013
    ..The authors' findings demonstrate that chronic PFOS exposure during different life stages adversely affects adult behavior and F1 offspring morphology, behavior, and survival...
  46. pmc Serum perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) concentrations and liver function biomarkers in a population with elevated PFOA exposure
    Valentina Gallo
    Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Environ Health Perspect 120:655-60. 2012
    ..Studies in humans have reported inconsistent associations between PFOA and liver enzymes...
  47. pmc Perfluorinated compounds and subfecundity in pregnant women
    Kristina W Whitworth
    Department of Health and Human Services, National Institute for Environmental Health Sciences, National Institutes of Health, Durham, NC 27709, USA
    Epidemiology 23:257-63. 2012
    ..We examined subfecundity in relation to 2 perfluorinated compounds-perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA)...
  48. pmc Concentrations of perfluorooctane sulfonate (PFOS) and perfluorooctanoate (PFOA) and their associations with human semen quality measurements
    James H Raymer
    RTI International, 3040 Cornwallis Road, P O Box 12194, Research Triangle Park, NC 27709, United States
    Reprod Toxicol 33:419-27. 2012
    ..Luteinizing hormone was positively correlated with plasma PFOA and PFOS, but not semen PFOS. Important methodological concerns included the lack of multiple hormonal measurements necessary to address circadian rhythms...
  49. ncbi Perfluorinated compounds differentially affect steroidogenesis and viability in the human adrenocortical carcinoma (H295R) in vitro cell assay
    Marianne Kraugerud
    Department of Production Animal Clinical Sciences, Norwegian School of Veterinary Science, Postboks 8146 Dep, 0033 Oslo, Norway
    Toxicol Lett 205:62-8. 2011
    ..Additionally, PFCs appear to differentially affect cell viability with induction of cell death via apoptosis at high doses of PFNA...
  50. ncbi Human donor liver and serum concentrations of perfluorooctanesulfonate and other perfluorochemicals
    Geary W Olsen
    3M Medical Department, 220 3W 05, St Paul, Minnesota 55144, USA
    Environ Sci Technol 37:888-91. 2003
    ..This information may be useful in human risk characterization for PFOS. Liver to serum ratios were not estimated for PFOA, PFHxS, and PFOSA as 90% of the human donor liver samples were determined to be less than the LOQ...
  51. ncbi Association of Perfluorooctanoic Acid (PFOA) and Perfluorooctane Sulfonate (PFOS) with age of puberty among children living near a chemical plant
    Maria José Lopez-Espinosa
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
    Environ Sci Technol 45:8160-6. 2011
    ..In conclusion, our study showed a later age of puberty in this population correlated with PFC concentrations...
  52. ncbi Changes in concentrations of perfluorinated compounds, polybrominated diphenyl ethers, and polychlorinated biphenyls in Norwegian breast-milk during twelve months of lactation
    Cathrine Thomsen
    Department of Analytical Chemistry, Division of Environmental Medicine, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Sci Technol 44:9550-6. 2010
    ..There were no significant differences in isomer pattern between the mothers, or changes during the lactation period. After a year of nursing the breast-milk concentrations of PFCs, PBDEs, and PCBs were reduced by 15-94%...
  53. ncbi Inflammation-like glial response in rat brain induced by prenatal PFOS exposure
    Huai Cai Zeng
    Ministry of Education Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    Neurotoxicology 32:130-9. 2011
    ....
  54. ncbi A temporal trend study (1972-2008) of perfluorooctanesulfonate, perfluorohexanesulfonate, and perfluorooctanoate in pooled human milk samples from Stockholm, Sweden
    Maria Sundström
    Environmental Chemistry Unit, Department of Materials and Environmental Chemistry, Stockholm University, Stockholm, Sweden
    Environ Int 37:178-83. 2011
    ..The temporal concentration trends of PFOS, PFHxS, and PFOA observed in human milk are parallel to those reported in the general population serum concentrations...
  55. ncbi Perfluorooctanesulfonate and perfluorooctanoic acid exposures of the Italian general population
    Anna Maria Ingelido
    Department of the Environment and Primary Prevention, Italian National Institute for Health, Viale Regina Elena, 299, 00161 Rome, Italy
    Chemosphere 80:1125-30. 2010
    ..005) but not for males (p>0.1). The observed strong correlation between PFOS and PFOA concentrations suggests same or similar exposure routes...
  56. ncbi Binding of perfluorinated fatty acids to serum proteins
    Paul D Jones
    Department of Zoology, National Food Safety and Toxicology Center, Institute for Environmental Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    Environ Toxicol Chem 22:2639-49. 2003
    ..Concentrations of PFOS required to saturate albumin would be in excess of 50 to 100 mg/L. Based on current environmental concentrations, it is unlikely that PFOS would cause displacement of hormones from serum proteins in wildlife...
  57. ncbi Perfluorooctane sulfonate induces neuronal and oligodendrocytic differentiation in neural stem cells and alters the expression of PPARγ in vitro and in vivo
    Wan Norhamidah Wan Ibrahim
    Department of Neuroscience, Karolinska Institutet, S 17177 Stockholm, Sweden
    Toxicol Appl Pharmacol 269:51-60. 2013
    ..These data suggest that PPARγ plays a role in the alteration of spontaneous differentiation of NSCs induced by nanomolar concentrations of PFOS...
  58. ncbi Developmental toxicity of perfluorooctane sulfonate (PFOS) is not dependent on expression of peroxisome proliferator activated receptor-alpha (PPAR alpha) in the mouse
    Barbara D Abbott
    Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US Environmental Protection Agency, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:258-65. 2009
    ..Because results in WT and KO were comparable, it is concluded that PFOS-induced neonatal lethality and delayed eye opening are not dependent on activation of PPAR alpha...
  59. ncbi Effects of perfluorooctanesulfonate exposure on plasma lipid levels in the Inuit population of Nunavik (Northern Quebec)
    Marie Ludivine Chateau-Degat
    Axe santé des populations et environnementale, Research center of the Centre hospitalier universitaire de Québec and Université Laval, Quebec, QC, Canada G1V 2M2
    Environ Res 110:710-7. 2010
    ..The Inuit of Nunavik are exposed to environmental contaminants through the consumption of fish and game. This diet is also a source of omega3-polyunsaturated fatty acids (n-3 PUFAs) that are known to lower plasma triacylglycerols...
  60. pmc Perfluoroalkyl chemicals and chronic kidney disease in US adults
    Anoop Shankar
    Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, WV 26506, USA
    Am J Epidemiol 174:893-900. 2011
    ..04, 2.88; P for trend = 0.015) for perfluorooctanoic acid and 1.82 (95% confidence interval: 1.01, 3.27; P for trend = 0.019) for perfluorooctane sulfonate. The present results suggest that elevated PFC levels are associated with CKD...
  61. ncbi High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a simil
    Mousumi R Qazi
    Department of Biochemistry and Biophysics, Arrhenius Laboratories for the Natural Sciences, Stockholm University, SE 106 91 Stockholm, Sweden
    Toxicology 262:207-14. 2009
    ..001%, w/w). These findings reveal that in addition to suppressing adaptive immunity, high-dose, short-term exposure of mice to either PFOS or PFOA augments inflammatory responses to LPS, a potent activator of innate immunity...
  62. ncbi Exposure to polyfluoroalkyl chemicals during pregnancy is not associated with offspring age at menarche in a contemporary British cohort
    Krista Yorita Christensen
    Epidemiology Department, Rollins School of Public Health, Emory University, Atlanta, Georgia 30322, USA
    Environ Int 37:129-35. 2011
    ..We used data from the Avon Longitudinal Study of Parents and Children (ALSPAC) in the United Kingdom to conduct a nested case-control study examining the association between age at menarche, and exposure to PFCs during pregnancy...
  63. ncbi Perfluorinated acids and hypothyroxinemia in pregnant women
    Emily Chan
    Department of Public Health Sciences, School of Public Health, University of Alberta, Edmonton, Alberta, Canada
    Environ Res 111:559-64. 2011
    ..The current findings do not support a causal link between PFA exposure and maternal hypothyroxinemia in the studied population...
  64. ncbi Maternal concentrations of perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) and duration of breastfeeding
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, UCLA, Box 951772, 650 Charles E Young Drive South, Los Angeles, CA 90095 1772, USA
    Scand J Work Environ Health 36:413-21. 2010
    ..Perfluorooctanoate (PFOA) has been associated with impaired lactation in mice. We examined whether maternal perfluorooctanesulfonate (PFOS) and PFOA concentrations correlated with duration of breastfeeding among women...
  65. ncbi Characterisation of human exposure pathways to perfluorinated compounds--comparing exposure estimates with biomarkers of exposure
    Line S Haug
    Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Int 37:687-93. 2011
    ..Even though food in general is the major source of exposure for PFCs, the indoor environment may be an important contributor to human exposure. This study provides valuable knowledge for risk assessment of PFCs and control strategies...
  66. ncbi Perfluorooctanesulfonate and related fluorinated hydrocarbons in marine mammals, fishes, and birds from coasts of the Baltic and the Mediterranean Seas
    Kurunthachalam Kannan
    National Food Safety and Toxicology Center, Department of Zoology, Institute for Environmental Toxicology, Michigan State University, East Lansing 48824, USA
    Environ Sci Technol 36:3210-6. 2002
    ..PFOS is a widespread contaminant in wildlife from the Baltic and the Mediterranean Seas, while FOSA and PFOA were detected only in certain locations indicating their sporadic spatial distribution...
  67. pmc Perfluorinated chemicals and fetal growth: a study within the Danish National Birth Cohort
    Chunyuan Fei
    Department of Epidemiology, University of California, Los Angeles, California 90095 1772, USA
    Environ Health Perspect 115:1677-82. 2007
    ..They have been found to interfere with fetal growth in some animal models, but whether a similar effect is seen in humans is uncertain...
  68. ncbi Serum levels of perfluorooctanoic acid and perfluorooctane sulfonate and pregnancy outcome
    Cheryl R Stein
    Department of Community and Preventive Medicine, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Am J Epidemiol 170:837-46. 2009
    ....
  69. ncbi Renal clearance of perfluorooctane sulfonate and perfluorooctanoate in humans and their species-specific excretion
    Kouji Harada
    Department of Health and Environmental Sciences, Kyoto University, Graduate School of Medicine, Yoshida Konoecho, Kyoto 606 8501, Japan
    Environ Res 99:253-61. 2005
    ..We therefore suggest that an internal dose approach using a pharmacokinetic model should be taken because of the large species differences in kinetics that exist for PFOA and PFOS...
  70. ncbi Modeling the global fate and transport of perfluorooctane sulfonate (PFOS) and precursor compounds in relation to temporal trends in wildlife exposure
    James M Armitage
    Department of Applied Environmental Science ITM, Stockholm University, SE 10691 Stockholm, Sweden
    Environ Sci Technol 43:9274-80. 2009
    ....
  71. ncbi Prenatal and postnatal impact of perfluorooctane sulfonate (PFOS) on rat development: a cross-foster study on chemical burden and thyroid hormone system
    Wen Guang Yu
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education, Dalian 116024, China
    Environ Sci Technol 43:8416-22. 2009
    ....
  72. ncbi Determinants of plasma concentrations of perfluorooctanesulfonate and brominated organic compounds in Nunavik Inuit adults (Canada)
    Renee Dallaire
    Public Health Research Unit, Centre Hospitalier Universitaire de Québec CHUL, Quebec, Quebec, Canada
    Environ Sci Technol 43:5130-6. 2009
    ..In conclusion, we found that the remote geographical location and traditional lifestyle of the Nunavik Inuit population do not protect them against exposure to emerging POPs, particularly PFOS...
  73. ncbi Structure-activity relationships for association of linear alkylbenzene sulfonates with activated sludge
    M T Garcia
    Department of Surfactant Technology, IIQAB CSIC, Barcelona, Spain
    Chemosphere 49:279-86. 2002
    ..An empirical equation was provided that allow to estimate the partition coefficient between aqueous and solid phases for LAS homologues as a function of the alkyl chain length and the water hardness...
  74. ncbi Comparison between free serum thyroxine levels, measured by analog and dialysis methods, in the presence of perfluorooctane sulfonate and perfluorooctanoate
    Maria José Lopez-Espinosa
    Department of Social and Environmental Health Research, London School of Hygiene and Tropical Medicine, 15 17 Tavistock Place, London WC1H 9SH, United Kingdom
    Reprod Toxicol 33:552-5. 2012
    ..The present findings do not indicate any observable bias from the use of the analog with respect to the dialysis method, across the range of PFOS and PFOA concentrations in this population...
  75. pmc Association of osteoarthritis with serum levels of the environmental contaminants perfluorooctanoate and perfluorooctane sulfonate in a large Appalachian population
    Kim E Innes
    Department of Community Medicine, School of Medicine, West Virginia University, Morgantown, USA
    Am J Epidemiol 174:440-50. 2011
    ....
  76. ncbi Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice
    Mousumi Rahman Qazi
    Department of Biochemistry and Biophysics, Stockholm University, Stockholm, Sweden
    Int Immunopharmacol 10:1420-7. 2010
    ..Thus, in mice, PFOA- and PFOS-induced hepatomegaly is associated with significant alterations in hepatic histophysiology and immune status, as well as induction of hepatic erythropoiesis...
  77. ncbi Testicular signaling is the potential target of perfluorooctanesulfonate-mediated subfertility in male mice
    H T Wan
    Croucher Institute of Environmental Sciences, Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China
    Biol Reprod 84:1016-23. 2011
    ..e., StAR, CYP11A1, CYP17A1, 3beta-HSD, and 17beta-HSD) were notably reduced. Therefore, PFOS-elicited subfertility in male mice is manifested as progressive deterioration of testicular signaling...
  78. ncbi Possible mechanism of perfluorooctane sulfonate and perfluorooctanoate on the release of calcium ion from calcium stores in primary cultures of rat hippocampal neurons
    Xiaohui Liu
    School of Environmental Science and Technology, Dalian University of Technology, Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education, Dalian 116024, China
    Toxicol In Vitro 25:1294-301. 2011
    ..IP(3)Rs seem to serve a predominant role in PFOS-induced calcium release. Calcium release from intracellular stores may partially account for the perturbation of calcium homeostasis caused by PFOS or PFOA...
  79. ncbi Analysis of episodes of care in a perfluorooctanesulfonyl fluoride production facility
    Geary W Olsen
    3M Medical Company, Medical Department, St Paul, Minnesota 55144, USA
    J Occup Environ Med 46:837-46. 2004
    ..Non-a priori associations among the fluorochemical plant workers included benign colon polyps, malignant colorectal tumors, and malignant melanoma...
  80. ncbi Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells
    Kirsten Thorup Eriksen
    Department of Public Health, Section of Environmental Health, University of Copenhagen, Øster Farimagsgade 5A, DK 1014 Copenhagen K, Denmark
    Mutat Res 700:39-43. 2010
    ..This was not related to ROS generation. Collectively, these results indicate that PFCs induce only modest effects in terms of ROS production and DNA damage in a cell line representing the human liver...
  81. pmc Perfluorooctane sulfonate (PFOS) and related perfluorinated compounds in human maternal and cord blood samples: assessment of PFOS exposure in a susceptible population during pregnancy
    Koichi Inoue
    Department of Analytical Chemistry, Faculty of Pharmaceutical Sciences, Hoshi University, 2 4 41 Ebara, Shinagawa ku, Tokyo 142 8501, Japan
    Environ Health Perspect 112:1204-7. 2004
    ..Further investigation is required to determine the postnatal effects of fetal exposure to FOCs. Key words: cord blood, fluorinated organic compounds, human, PFOA, PFOS, PFOSA, pregnancy...
  82. ncbi Estimated dietary exposure to fluorinated compounds from traditional foods among Inuit in Nunavut, Canada
    Sonja K Ostertag
    Department of Natural Resource Sciences, McGill University, Macdonald Campus, Sainte Anne de Bellevue, Quebec, Canada H9X 3V9
    Chemosphere 75:1165-72. 2009
    ..However, it is important to monitor the concentrations of PFCs in key food items given that PFCA levels have been found to be increasing in the Canadian Arctic...
  83. ncbi Historical trends in human serum levels of perfluorooctanoate and perfluorooctane sulfonate in Shenyang, China
    Yihe Jin
    Department of Environmental Science and Technology, Dalian University of Technology, Dalian, P R China
    Tohoku J Exp Med 212:63-70. 2007
    ..6 microg/l and 8.3 microg/l in median, respectively) are comparable to those in Italy. The data from this study indicate that females are likely to experience higher exposure to these chemicals...
  84. ncbi [Effects of perfluorooctane sulfonate on Glu, PKC and PKA activities in mouse brain]
    Ke Wang
    Department of Hygiene Toxicology, School of Public Health, China Medical University, Shenyang 110001, China
    Zhonghua Yu Fang Yi Xue Za Zhi 41:466-70. 2007
    ....
  85. ncbi Perfluorooctane sulfonate concentrations in surface water in Japan
    N Saito
    Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka Iwate, Japan
    Arch Environ Contam Toxicol 45:149-58. 2003
    ..0-38.5 ng/L), Tama (0.7-157.0 ng/L), and Yodo (0.9-27.3 ng/L) Rivers, sources of drinking water for more than eight million people, were moderately contaminated with PFOS, more work is needed to assess exposure to PFOS...
  86. ncbi Acute enhancement of synaptic transmission and chronic inhibition of synaptogenesis induced by perfluorooctane sulfonate through mediation of voltage-dependent calcium channel
    Chun yang Liao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
    Environ Sci Technol 42:5335-41. 2008
    ..Thus, through enhancement of Ca2+ channels, PFOS may exhibit both acute excitotoxic effects on synaptic function and chronically inhibit synaptogenesis in the brain...
  87. ncbi Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: toxicokinetics, thyroid hormone status, and related gene expression
    Shu Ching Chang
    Medical Department, 3M Company, St Paul, MN 55144, USA
    Reprod Toxicol 27:387-99. 2009
    ..1-fold over control in GD 20 female fetuses from 1.0mg/kg-d-treated dams, yet the highest individual count was similar to that of controls (116 versus 113 in controls)...
  88. ncbi Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats: developmental neurotoxicity
    John L Butenhoff
    Medical Department, 3M Company, 3M Center 220 6W 08, Saint Paul, MN 55144, USA
    Reprod Toxicol 27:319-30. 2009
    ..0mg/kg-d. Mean serum concentrations of PFOS reported in a companion article for the 0.3mg/kg-d group maternal rats are several hundred times higher than those reported for females in the United States general population...
  89. ncbi Fetal growth indicators and perfluorinated chemicals: a study in the Danish National Birth Cohort
    Chunyuan Fei
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 1772, USA
    Am J Epidemiol 168:66-72. 2008
    ..Maternal PFOS levels were not associated with any of the five fetal growth indicators. These findings suggest that fetal exposure to PFOA but not PFOS during organ development may affect the growth of organs and the skeleton...
  90. ncbi Two-year follow-up biomonitoring pilot study of residents' and controls' PFC plasma levels after PFOA reduction in public water system in Arnsberg, Germany
    Edna Brede
    Department of Hygiene, Social and Environmental Medicine, Ruhr University Bochum, Germany
    Int J Hyg Environ Health 213:217-23. 2010
    ..The decline of PFC levels in plasma of participants from the reference areas reflects the general decrease of human PFC exposure during the very recent years...
  91. ncbi Dietary exposure of Canadians to perfluorinated carboxylates and perfluorooctane sulfonate via consumption of meat, fish, fast foods, and food items prepared in their packaging
    Sheryl A Tittlemier
    Food Research Division, Banting Research Centre 2203D, and Chemical Health Hazard Assessment Division, Banting Research Centre 2204D, Health Canada, Ottawa, Ontario K1A 0L2, Canada
    J Agric Food Chem 55:3203-10. 2007
    ..There was a substantial margin of exposure between the toxicological points of reference and the magnitude of dietary intake of perfluorinated compounds for Canadians >/= 12 years old...
  92. ncbi Influence of water hardness on the bioavailability and toxicity of linear alkylbenzene sulphonate (LAS)
    C Verge
    PETRESA, , Spain
    Chemosphere 44:1749-57. 2001
    ....
  93. ncbi Quantitative characterization of trace levels of PFOS and PFOA in the Tennessee River
    K J Hansen
    3M Environmental Laboratory and 3M Medical Department, St Paul, Minnesota 55133 3331, USA
    Environ Sci Technol 36:1681-5. 2002
    ..Concentrations of the measured fluorochemicals increased downstream of the fluorochemical manufacturing facility, indicating that effluent from manufacturing is one likely source of organic fluorochemicals into the river...
  94. ncbi Occurrence of perfluorosulfonates and other perfluorochemicals in dust from selected homes in the city of Ottawa, Canada
    Cariton Kubwabo
    Health Canada, Healthy Environments and Consumer Safety Branch, Safe Environments Programme, Tunney s Pasture, Building No 8, Ottawa Ontario PL 0800C, CanadaK1A 0L2
    J Environ Monit 7:1074-8. 2005
    ..The data revealed a correlation between the concentrations of PFCs and the percentage of carpeting in the house; older houses tended to have less carpeting, hence lower levels of these perfluorinated compounds in their dust...
  95. ncbi Effects of perfluorooctane sulfonate on rat thyroid hormone biosynthesis and metabolism
    Wen Guang Yu
    School of Environmental and Biological Science and Technology, Dalian University of Technology, Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education, Linggong Road 2, Dalian 116024, China
    Environ Toxicol Chem 28:990-6. 2009
    ..These results indicate that increased hepatic T4 glucuronidation via UGT1A1 and increased thyroidal conversion of T4 to T3 via DIO1 were responsible in part for PFOS-induced hypothyroxinemia in rats...
  96. ncbi Fluorescence study on site-specific binding of perfluoroalkyl acids to human serum albumin
    Yan Min Chen
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco Environmental Sciences, Chinese Academy of Sciences, P O Box 2871, 18 Shuangqing Road, 100085, Beijing, China
    Arch Toxicol 83:255-61. 2009
    ..5 x 10(6) M(-1) and 1.2 x 10(6) M(-1), whereas PFBA did not bind. The data were compared with fatty acids to evaluate the potential toxicological effect of these environmental chemicals...
  97. ncbi Transplacental exposure of neonates to perfluorooctanesulfonate and perfluorooctanoate: a pilot study
    O Midasch
    Institute and Outpatient Clinic of Occupational, Social and Environmental Medicine, University of Erlangen Nuremberg, Schillerstrasse 25, 91054, Erlangen, Germany
    Int Arch Occup Environ Health 80:643-8. 2007
    ..On the basis of the comparison of maternal and umbilical cord plasma sample pairs we wanted to examine whether infants are exposed to PFOS and PFOA via their mothers' blood...
  98. ncbi Effects of PFOS and PFOA on L-type Ca2+ currents in guinea-pig ventricular myocytes
    Kouji Harada
    Department of Health and Environmental Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Biochem Biophys Res Commun 329:487-94. 2005
    ..These findings provide further insights into the mechanisms of PFOA and PFOS toxicities...
  99. ncbi Evidence for the involvement of xenobiotic-responsive nuclear receptors in transcriptional effects upon perfluoroalkyl acid exposure in diverse species
    Hongzu Ren
    NHEERL ORD, US EPA, Research Triangle Park, NC 27711, USA
    Reprod Toxicol 27:266-77. 2009
    ..Lastly, we discuss evidence that human populations with greater CAR expression have lower body burdens of PFAAs...
  100. ncbi Perfluorooctanesulfonate and related fluorochemicals in human blood from several countries
    Kurunthachalam Kannan
    Wadsworth Center, New York State Department of Health, and Department of Environmental Toxicology and Health, State University of New York, Empire State Plaza, P O Box 509, Albany, New York 12201 0509, USA
    Environ Sci Technol 38:4489-95. 2004
    ..Further studies should focus on identifying sources and pathways of human exposure to perfluorochemicals...
  101. ncbi Gestational exposure to perfluorooctane sulfonate suppresses immune function in B6C3F1 mice
    Deborah E Keil
    National Institute for Occupational Safety and Health, Morgantown, West Virginia 26505, USA
    Toxicol Sci 103:77-85. 2008
    ..This study establishes that the developing immune system is sensitive to the effects of PFOS and results in functional deficits in innate and humoral immunity detectable at adulthood...

Research Grants13

  1. Perfluorooctane sulfonate (PFOS) Affects Immunity through PPAR-alpha.
    Margie Peden Adams; Fiscal Year: 2007
    ..The unimmunized and immunized experiments will be conducted to control for possible differences in response related to lymphocyte activation from the immunization. [unreadable] [unreadable] [unreadable]..
  2. MECHANISMS OF CHLORPYRIFOS DEVELOPMENTAL NEUROTOXICITY
    Theodore Slotkin; Fiscal Year: 2004
    ..Molecular mechanisms of developmental neurotoxicity can be determined and linked to eventual alterations in behavioral performance. ..
  3. DRUGS AND DEVELOPMENT OF THE ADRENERGIC NERVOUS SYSTEM
    Theodore Slotkin; Fiscal Year: 2003
    ....
  4. Fetal & Adolescent Nicotine Effects on CNS 5HT Systems
    Theodore Slotkin; Fiscal Year: 2003
    ..abstract_text> ..
  5. Distribution of PCB Atropisomers
    Hans Joachim Lehmler; Fiscal Year: 2008
    ..The long term career goal is to establish Dr. Lehmler as an investigator with independent research status and funding. ..
  6. Perfluorocarbon Materials As Drug Delivery Vehicles
    Hans Joachim Lehmler; Fiscal Year: 2004
    ..abstract_text> ..
  7. IRON, ZINC AND FOLATE AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2001
    ..Although all are strongly suspected of influencing risk of preterm delivery, this study should provide evidence relevant to screening practice for infection and vitamin use during pregnancy. ..
  8. EPIDEMIOLOGY OF EXERTION, STRESS, AND PRETERM DELIVERY
    David Savitz; Fiscal Year: 2004
    ..abstract_text> ..
  9. Epidemiologic Evaluation of Perfluorooctyl Compounds
    James Raymer; Fiscal Year: 2003
    ..If the exposure effect is limited to a sensitive subset of the general population, our study is more likely to detect an association compared to studies that sample on PFOA/PFOS exposure status in an occupational setting. ..
  10. Quantitating Absorption of Complex Chemical Mixtures
    Jim Riviere; Fiscal Year: 2009
    ..abstract_text> ..
  11. Repiratory Health and Community Asbestos Exposure
    Bruce Alexander; Fiscal Year: 2007
    ..Analyses will consider cumulative exposure and short, intense periods of exposure, with specific reference to exposure in childhood. ..
  12. BIOCHEMICAL CHARACTERIZATION OF PPAR
    JOHN VANDEN HEUVEL; Fiscal Year: 2008
    ..Taken together the proposed studies will greatly enhance our knowledge of PPARalpha's mechanism of action and hence our understanding of an important class of carcinogen. ..