fluphenazine

Summary

Summary: A phenothiazine used in the treatment of PSYCHOSES. Its properties and uses are generally similar to those of CHLORPROMAZINE.

Top Publications

  1. ncbi Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis
    Christoph Bachmeyer
    CNR ITC Istituto di Biofisica Sezione di Trento, Via Sommarive 18, I 38050, Povo, Italy
    J Mol Biol 333:527-40. 2003
  2. ncbi Resveratrol reduces vacuous chewing movements induced by acute treatment with fluphenazine
    Alcindo Busanello
    Programa de Pos Graduacao em Bioquimica Toxicologica, Universidade Federal de Santa Maria, RS, Brazil
    Pharmacol Biochem Behav 101:307-10. 2012
  3. ncbi Interaction of chlorpromazine, fluphenazine and trifluoperazine with ocular and synthetic melanin in vitro
    E Buszman
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Sosnowiec, Poland
    Pharmazie 63:372-6. 2008
  4. pmc Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats
    Thomas E Wooters
    Department of Psychology, University of Kentucky, Lexington, 40536, USA
    Brain Res 1396:45-53. 2011
  5. ncbi In vitro and in vivo antimicrobial action of fluphenazine
    S G Dastidar
    Dept of Pharmaceutical Technology, Jadavpur University, Calcutta, India
    J Chemother 7:201-6. 1995
  6. ncbi Antifertility effects of fluphenazine in adult male rats
    M K Gill-Sharma
    Department of Neuroendocrinology, National Institute for Research in Reproductive Health ICMR, Parel, Mumbai, India
    J Endocrinol Invest 26:316-26. 2003
  7. ncbi Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine
    Deanna L Kelly
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychiatry 66:80-4. 2005
  8. ncbi A randomized double-blind 12-week study of quetiapine, risperidone or fluphenazine on sexual functioning in people with schizophrenia
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland, Box 21247, Baltimore, 21228, USA
    Psychoneuroendocrinology 31:340-6. 2006
  9. ncbi Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats
    Brendan M Walker
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USA
    Behav Neurosci 121:401-10. 2007
  10. ncbi Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia
    Lizheng Shi
    Department of Health Systems Management, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St, Suite 1900, New Orleans, LA 70112, USA
    Psychiatr Serv 58:482-8. 2007

Detail Information

Publications202 found, 100 shown here

  1. ncbi Mechanism of C2-toxin inhibition by fluphenazine and related compounds: investigation of their binding kinetics to the C2II-channel using the current noise analysis
    Christoph Bachmeyer
    CNR ITC Istituto di Biofisica Sezione di Trento, Via Sommarive 18, I 38050, Povo, Italy
    J Mol Biol 333:527-40. 2003
    ..The C2II-channel is cation selective and contains a binding site for fluphenazine and structurally related compounds...
  2. ncbi Resveratrol reduces vacuous chewing movements induced by acute treatment with fluphenazine
    Alcindo Busanello
    Programa de Pos Graduacao em Bioquimica Toxicologica, Universidade Federal de Santa Maria, RS, Brazil
    Pharmacol Biochem Behav 101:307-10. 2012
    ..in red grapes and red wine, in an animal model of orofacial dyskinesia (OD) induced by acute treatment with fluphenazine. Adult male rats were treated during 3 weeks with fluphenazine enantate (25 mg/kg, i.m...
  3. ncbi Interaction of chlorpromazine, fluphenazine and trifluoperazine with ocular and synthetic melanin in vitro
    E Buszman
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Medical University of Silesia, Sosnowiec, Poland
    Pharmazie 63:372-6. 2008
    ..of this study was to examine in vitro the binding capacity of three phenothiazine derivatives--chlorpromazine, fluphenazine and trifluoperazine--causing adverse effects in the eye structures, to natural melanin isolated from pig eyes ..
  4. pmc Methylphenidate and fluphenazine, but not amphetamine, differentially affect impulsive choice in spontaneously hypertensive, Wistar-Kyoto and Sprague-Dawley rats
    Thomas E Wooters
    Department of Psychology, University of Kentucky, Lexington, 40536, USA
    Brain Res 1396:45-53. 2011
    ..0-10 mg/kg) were then determined; in addition, the effect of the dopamine receptor antagonist fluphenazine (0.1-1.0 mg/kg) was also assessed for comparison with the indirect agonists...
  5. ncbi In vitro and in vivo antimicrobial action of fluphenazine
    S G Dastidar
    Dept of Pharmaceutical Technology, Jadavpur University, Calcutta, India
    J Chemother 7:201-6. 1995
    The antipsychotic drug fluphenazine was obtained in a dry powder form and was screened with respect to 482 strains of bacteria, which included 170 Gram-positive and 326 Gram-negative strains...
  6. ncbi Antifertility effects of fluphenazine in adult male rats
    M K Gill-Sharma
    Department of Neuroendocrinology, National Institute for Research in Reproductive Health ICMR, Parel, Mumbai, India
    J Endocrinol Invest 26:316-26. 2003
    ..Hyperprolactinemia is a known side-effect of fluphenazine, a broad spectrum, long-acting phenothiazine known to be D2 dopamine receptor antagonist...
  7. ncbi Thyroid function in treatment-resistant schizophrenia patients treated with quetiapine, risperidone, or fluphenazine
    Deanna L Kelly
    Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA
    J Clin Psychiatry 66:80-4. 2005
    ..Furthermore, the need for thyroid function monitoring in patients taking this medication is not definitive...
  8. ncbi A randomized double-blind 12-week study of quetiapine, risperidone or fluphenazine on sexual functioning in people with schizophrenia
    Deanna L Kelly
    Maryland Psychiatric Research Center, University of Maryland, Box 21247, Baltimore, 21228, USA
    Psychoneuroendocrinology 31:340-6. 2006
    ..participated in a randomized double-blind 12-week trial of risperidone (4 mg/day), quetiapine (400 mg/day) or fluphenazine (12.5 mg/day)...
  9. ncbi Intracerebroventricular ethanol-induced conditioned place preferences are prevented by fluphenazine infusions into the nucleus accumbens of rats
    Brendan M Walker
    Behavioral Pharmacology Laboratory, Department of Psychology, University of California, Santa Barbara, CA 93106, USA
    Behav Neurosci 121:401-10. 2007
    ..b>Fluphenazine (10 or 50 microg/side), infused immediately prior to daily place conditioning trials, was found to reliably ..
  10. ncbi Characteristics and use patterns of patients taking first-generation depot antipsychotics or oral antipsychotics for schizophrenia
    Lizheng Shi
    Department of Health Systems Management, School of Public Health and Tropical Medicine, Tulane University, 1440 Canal St, Suite 1900, New Orleans, LA 70112, USA
    Psychiatr Serv 58:482-8. 2007
    ....
  11. ncbi Systemic relaxin in pregnant pony mares grazed on endophyte-infected fescue: effects of fluphenazine treatment
    P L Ryan
    Department of Molecular Biology, Princeton University, NJ, USA
    Theriogenology 56:471-83. 2001
    ..The objectives of this study were to determine the effects of fescue toxicosis and fluphenazine on circulating relaxin in pregnant pony mares and evaluate the usefulness of relaxin as a monitor of treatment ..
  12. ncbi The antipsychotic drug, fluphenazine, effectively reverses mechanical allodynia in rat models of neuropathic pain
    Xiao Wei Dong
    Department of Neurobiology, Schering Plough Research Institute, K 15 2 2600, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Psychopharmacology (Berl) 195:559-68. 2008
    b>Fluphenazine is a potent antipsychotic drug used to treat schizophrenia and other psychotic symptoms. Its clinical benefit is mainly mediated by the antagonism of dopamine D2 receptors...
  13. pmc Treatment of schizophrenia with long-acting fluphenazine, haloperidol, or risperidone
    Mark Olfson
    Division of Clinical and Genetic Epidemiology, New York State Psychiatric Institute, New York, NY, USA
    Schizophr Bull 33:1379-87. 2007
    This study compares 3 cohorts of patients with schizophrenia before, during, and after initiating treatment with fluphenazine decanoate (FD), haloperidol decanoate (HD), or long-acting injectable risperidone (LAR).
  14. ncbi Chronic treatment with fluphenazine alters parameters of oxidative stress in liver and kidney of rats
    Cristiane L Dalla Corte
    Federal University of Santa Maria, Center of Exacts and Natural Sciences, Chemistry Department, Graduation Program of Toxicological Biochemistry, Santa Maria, RS, Brazil
    Basic Clin Pharmacol Toxicol 105:51-7. 2009
    The aim of this study was to assess the toxic effects of chronic exposure to fluphenazine in liver and kidney of rats, as well as the possible protective effect of diphenyl diselenide on the fluphenazine-induced damage...
  15. ncbi Risperidone, quetiapine, and fluphenazine in the treatment of patients with therapy-refractory schizophrenia
    Robert R Conley
    Maryland Psychiatric Research Center, Treatment Research Unit, University of Maryland, Baltimore 21228, USA
    Clin Neuropharmacol 28:163-8. 2005
    ..12-week, double-blind study evaluated the effectiveness of risperidone (4 mg/day), quetiapine (400 mg/day), or fluphenazine (12.5 mg/day) in a stringently defined treatment-resistant population of people with schizophrenia...
  16. ncbi Fluphenazine levels during maintenance treatment of recent-onset schizophrenia: relation to side effects, psychosocial function and depression
    M J Gitlin
    Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, 90095 6968, USA
    Psychopharmacology (Berl) 148:350-4. 2000
    The utility of fluphenazine levels during maintenance treatment of schizophrenia is still unclear.
  17. ncbi Spectrofluorometric determination of olanzapine and fluphenazine hydrochloride in pharmaceutical preparations and human plasma using eosin: application to stability studies
    Fathalla Belal
    University of Mansoura, Faculty of Pharmacy, Department of Analytical Chemistry, 35516 Mansoura, Egypt
    J AOAC Int 91:1309-17. 2008
    ..and sensitive spectrofluorometric method has been developed for the determination of olanzapine (OLZ) and fluphenazine hydrochloride (FPZ HCI)...
  18. ncbi Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate
    S R Marder
    VA Greater Los Angeles Health Care System, West Los Angeles Health Center and the Department of Psychiatry and Biobehavioral Sciences, UCLA, Los Angeles, CA 90073, USA
    Schizophr Res 53:25-30. 2002
    ..With this in mind, we evaluated the usefulness of monitoring fluphenazine plasma levels for patients with schizophrenia who were receiving maintenance treatment with fluphenazine ..
  19. ncbi Clinical outcome following neuroleptic discontinuation in patients with remitted recent-onset schizophrenia
    M Gitlin
    UCLA Department of Psychiatry and Biobehavioral Sciences, 90095, USA
    Am J Psychiatry 158:1835-42. 2001
    ..patients with recent-onset schizophrenia who had been clinically stabilized on a maintenance regimen of fluphenazine decanoate for a mean of 16.7 months had their antipsychotic medications withdrawn under clinical supervision...
  20. ncbi Identification of P-glycoprotein substrates and inhibitors among psychoactive compounds--implications for pharmacokinetics of selected substrates
    Amal Abou El Ela
    Institute of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, University of Mainz, Germany
    J Pharm Pharmacol 56:967-75. 2004
    ..study, the psychoactive compounds perphenazine, flupentixol, domperidone, desmethyl clozapine, haloperidol, fluphenazine, fluvoxamine, olanzapine, levomepromazine, perazine, desmethyl perazine, clozapine, quetiapine and amisulpride ..
  21. ncbi Clozapine as a first treatment for schizophrenia
    Margaret G Woerner
    Department of Psychiatry, Zucker Hillside Hospital of the North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Am J Psychiatry 160:1514-6. 2003
    ..The authors' goal was to explore whether clozapine given as the first antipsychotic treatment favorably affects the course of schizophrenia...
  22. ncbi Time to discontinuation of depot and oral first-generation antipsychotics in the usual care of schizophrenia
    Baojin Zhu
    Eli Lilly and Company, Lilly Corporate Center Drop 4133, Indianapolis, IN 46285, USA
    Psychiatr Serv 59:315-7. 2008
    ..This study compared the time to discontinuation for any reason of first-generation antipsychotics--in oral versus depot formulation--in the usual care of schizophrenia...
  23. doi Neuroleptic malignant syndrome presenting with acute renal failure
    Harpreet S Duggal
    Prog Neuropsychopharmacol Biol Psychiatry 32:1074-5. 2008
  24. ncbi Long-acting injectable risperidone: safety and efficacy in stable patients switched from conventional depot antipsychotics
    Martin Turner
    The Larkfield Centre, Glasgow, UK
    Int Clin Psychopharmacol 19:241-9. 2004
    ..Participants in this open-label, multicentre, 12-week trial had received flupenthixol decanoate, fluphenazine decanoate, haloperidol decanoate, or zuclopenthixol decanoate for 4 months or longer...
  25. ncbi Clozapine and tardive dyskinesia
    Del D Miller
    Am J Psychiatry 160:588. 2003
  26. ncbi Efficacy and tolerability of quetiapine in poorly responsive, chronic schizophrenia
    Peter F Buckley
    Department of Psychiatry and Health Behavior Medical College of Georgia, 1515 Pope Avenue, Augusta, GA 30912, USA
    Schizophr Res 66:143-50. 2004
    ..of quetiapine and haloperidol in patients with schizophrenia who showed no response to treatment with fluphenazine. This study is a post hoc subanalysis of an 8-week, double-blind study of patients receiving quetiapine 600 mg/..
  27. ncbi Race, family interactions, and patient stabilization in schizophrenia
    Irwin S Rosenfarb
    California School of Professional Psychology, Alliant International University, San Diego, CA 92131, USA
    J Abnorm Psychol 113:109-15. 2004
    ..Findings suggest that family relationships may play in important role in determining whether patients stabilize after an acute episode. Results also point to the importance of cultural factors in predicting patient stabilization...
  28. ncbi Augmentation of clozapine partial responders with conventional antipsychotics
    Rajaprabhakaran Rajarethinam
    Schizophr Res 60:97-8. 2003
  29. ncbi The effect of age on the pharmacological management of ambulatory patients treated with depot neuroleptic medications for schizophrenia and related psychotic disorders
    David C Mamo
    Centre for Addiction and Mental Health, Toronto, Canada
    Int J Geriatr Psychiatry 17:1012-7. 2002
    ..It has been suggested, therefore, that older patients with schizophrenia could be maintained on reduced doses of conventional neuroleptics...
  30. ncbi Performance of diadochokinetic movements in schizophrenic patients
    Albert Putzhammer
    Movement Disorders Unit, Department of Psychiatry, University of Regensburg, Regensburg, Germany
    Schizophr Res 79:271-80. 2005
    ..performance of a diadochokinetic hand movement in 20 drug-naïve, 20 conventionally treated (haloperidol or fluphenazine), and 20 atypically treated (olanzapine) patients, as well as in 20 healthy controls using a three-dimensional ..
  31. ncbi Sexual side effects of novel antipsychotic medications
    Donna A Wirshing
    Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine and VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA
    Schizophr Res 56:25-30. 2002
    ..The novel antipsychotic medications offer a more favorable extrapyramidal side effect profile than conventional agents. It is uncertain that the novel antipsychotics have a benefit in terms of sexual side effects...
  32. ncbi Disturbed glucose metabolism among patients taking olanzapine and typical antipsychotics
    Boadie W Dunlop
    Mood and Anxiety Disorders Program, Department of Psychiatry, Emory University School of Medicine, Atlanta, GA 30329, USA
    Psychopharmacol Bull 37:99-117. 2003
    ..The four typical antipsychotics were haloperidol, fluphenazine, chlorpromazine, and perphenazine.Random plasma glucose values collected over the 4...
  33. ncbi Double-blind, randomized comparison of olanzapine versus fluphenazine in the long-term treatment of schizophrenia
    Martin R K Dossenbach
    Lilly Area Medical Center, Eli Lilly, Barichgasse 40 42, Vienna A 1030, Austria
    Prog Neuropsychopharmacol Biol Psychiatry 28:311-8. 2004
    This study was undertaken to evaluate the efficacy and safety of olanzapine compared with fluphenazine in the treatment of patients who met the Diagnostic and Statistical Manual, fourth edition (DSM-IV) diagnostic criteria for ..
  34. ncbi The therapeutic alliance and family psychoeducation in the treatment of schizophrenia: an exploratory prospective change process study
    Phyllis E Smerud
    California School of Professional Psychology, Alliant International University, San Diego, CA 92131, USA
    J Consult Clin Psychol 76:505-10. 2008
    ..PsycINFO Database Record (c) 2008 APA, all rights reserved)...
  35. ncbi Atypical (olanzapine) plus conventional (fluphenazine) neuroleptic treatment associated with the neuroleptic malignant syndrome
    Ian T Tofler
    J Clin Psychopharmacol 23:672-4. 2003
  36. ncbi Rehospitalization risk with second-generation and depot antipsychotics
    Robert R Conley
    Maryland Psychiatric Research Center, University of Maryland, Baltimore, Maryland 21228, USA
    Ann Clin Psychiatry 15:23-31. 2003
    ..were compared with those discharged from the two largest state facilities during the same time period on fluphenazine decanoate (N = 59) or haloperidol decanoate (N = 59)...
  37. ncbi Reward system activation in schizophrenic patients switched from typical neuroleptics to olanzapine
    Florian Schlagenhauf
    Department of Psychiatry and Psychotherapy, Charite University Medical Center, Campus Charite Mitte, Chariteplatz 1, 10117 Berlin, Germany
    Psychopharmacology (Berl) 196:673-84. 2008
    ..This may not be the case with newer neuroleptics such as olanzapine, which show less dopamine D2 receptor blockade and a faster off-rate from the receptor...
  38. ncbi Repeated antipsychotic drug exposure in developing rats: dopamine receptor effects
    Taylor Moran-Gates
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont 02478 9106, and Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, Massachusetts, USA
    Synapse 59:92-100. 2006
    ..forebrain regions of juvenile rats were quantified after 3 weeks of daily treatment with representative first- (fluphenazine) and second-generation (clozapine and olanzapine) antipsychotics, and compared with similarly treated adult ..
  39. ncbi Importance of oral glucose tolerance test in patient with schizophrenia
    Branimir Margetic
    Neuropsychiatric Hospital Dr Ivan Barbot 44317, Popovaca, Croatia
    Psychiatr Danub 17:94-6. 2005
    ..Recommendations about when and how often clinicians should administer the test do not exist in current guidelines. Further studies are needed for the elucidation of this question...
  40. ncbi The effects of olanzapine and fluphenazine on plasma cortisol, prolactin and muscle rigidity in schizophrenic patients: a double blind study
    M Jakovljevic
    Department of Psychiatry, Clinical Hospital Center Zagreb, Zagreb, Croatia
    Prog Neuropsychopharmacol Biol Psychiatry 31:399-402. 2007
    ..cortisol and prolactin/PRL) and muscle rigidity in female schizophrenic patients treated with olanzapine or fluphenazine. In a randomized, double-blind 22-weeks study, 12 patients were treated with olanzapine (5-20 mg/day) and 10 ..
  41. ncbi Treatment compliance of outpatients with schizophrenia: patient's attitudes, demographic, clinical and therapeutic variables
    Zana Stanković
    Institute of Psychiatry, Clinical Centre of Serbia, Serbia
    Psychiatr Danub 20:42-52. 2008
    ....
  42. ncbi In vitro phototoxicity of phenothiazines: involvement of stable UVA photolysis products formed in aqueous medium
    G Miolo
    Department of Pharmaceutical Sciences, University of Padova, Via F Marzolo 5, I 35131 Padova, Italy
    Chem Res Toxicol 19:156-63. 2006
    ..phototoxic potential of stable photoproducts formed by UVA photolysis of three phenothiazines, perphenazine, fluphenazine, and thioridazine, in a water environment. Perphenazine gave a single product due to dechlorination...
  43. ncbi Management of psychosis in Australian general practice
    Janice Charles
    AIHW Australian GP Statistics and Classification Centre, University of Sydney, New South Wales
    Aust Fam Physician 35:88-9. 2006
    ..This synopsis provides a backdrop against which the theme articles in this issue of Australian Family Physician can be further considered...
  44. ncbi Who receives long-acting antipsychotic medications?
    William M Glazer
    Psychiatr Serv 58:437. 2007
  45. ncbi Risks versus benefits of different types of long-acting injectable antipsychotics
    Joseph P McEvoy
    John Umstead Hospital, 1003 12th Street, Butner, NC 27509, USA
    J Clin Psychiatry 67:15-8. 2006
    ..By preventing or delaying relapse, consistent treatment can improve the patient's quality of life and lead to an overall reduction in the cost of care...
  46. ncbi The neuroleptic drug, fluphenazine, blocks neuronal voltage-gated sodium channels
    Xiaoping Zhou
    Department of CNS Neurobiology, Schering Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA
    Brain Res 1106:72-81. 2006
    b>Fluphenazine (Prolixin(R)) is a potent phenothiazine-based dopamine receptor antagonist, first introduced into clinical practice in the late 1950s as a novel antipsychotic...
  47. ncbi Insulin resistance index and counter-regulatory factors during olanzapine or risperidone administration in subjects with schizophrenia
    Trino Baptista
    Schizophr Res 89:350-2. 2007
  48. pmc Differential effects of typical and atypical antipsychotics on brain myelination in schizophrenia
    George Bartzokis
    Department of Neurology, The David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1769, United States
    Schizophr Res 93:13-22. 2007
    ..Atypical antipsychotics have been shown to have a wide spectrum of efficacy across multiple psychiatric diseases and to be particularly efficacious in treatment resistant cases of disorders such as schizophrenia...
  49. ncbi Second-generation antipsychotic drugs, olanzapine, quetiapine, and clozapine enhance neurite outgrowth in PC12 cells via PI3K/AKT, ERK, and pertussis toxin-sensitive pathways
    Xiao hong Lu
    Department of Pharmacology, Louisiana State University Health Sciences Center, Shreveport, LA 71130, USA
    J Mol Neurosci 27:43-64. 2005
    ..A better understanding of the mechanisms underlying the effects of the second-generation drugs might suggest new therapeutic targets for enhancement of neurite outgrowth...
  50. ncbi Fatal hyponatremia and other metabolic disturbances associated with psychotropic drug polypharmacy
    Z Vucicevic
    Department of Emergency Medicine, University Department of Medicine, Sestre Milosrdnice University Hospital, Zagreb, Croatia
    Int J Clin Pharmacol Ther 45:289-92. 2007
    To report a case of fatal hyponatremia, marked hyperglycemia, and acute pancreatitis following simultaneous administration of paroxetine, fluphenazine, haloperidol and olanzapine.
  51. ncbi Series of seizures as a sign of development of recurrent malignant neuroleptic syndrome - a case report
    Svjetlana Supe
    Department of Neurology, Zagreb University Hospital Centre, Croatia
    Psychiatr Danub 18:97-101. 2006
    ....
  52. ncbi [Alterations of gait parameters under external cueing in schizophrenic patients: a switch study]
    Albert Putzhammer
    Klinik und Poliklinik für Psychiatrie und Psychotherapie der Universität Regensburg
    Psychiatr Prax 31:S164-6. 2004
    ..We conclude that conventional neuroleptic treatment impairs the regulation of gait parameters and that this effect can be reversed at slow gait velocities by external stimulation via treadmill walking...
  53. ncbi Glycopyrrolate for clozapine-induced sialorrhea
    Harpreet S Duggal
    Prog Neuropsychopharmacol Biol Psychiatry 31:1546-7. 2007
  54. ncbi Densitometric high performance thin-layer chromatography identification and quantitative analysis of psychotropic drugs
    Anna Maslanka
    Jagiellonian University, Collegium Medicum, Department of Inorganic and Analytical Chemistry, 9 Medyczna St, 30 688 Krakow, Poland
    J AOAC Int 88:70-9. 2005
    ..method has been developed to identify and quantify haloperidol, amitriptyline, sulpiride, promazine, fluphenazine, doxepin, diazepam, trifluoperazine, clonazepam, and chlorpromazine in selected psychotropic drugs...
  55. ncbi Relative risk of glucose elevation during antipsychotic exposure in a Veterans Administration population
    Erica Duncan
    Mental Health Service, Atlanta VA Medical Center, Decatur GA 30033, USA
    Int Clin Psychopharmacol 22:1-11. 2007
    ..These data indicate that patients with no previously observed glucose elevations develop diabetes-level hyperglycemia during antipsychotic treatment, particularly in patients receiving olanzapine...
  56. ncbi Fluphenazine-induced neuroleptic malignant syndrome in a schizophrenic patient
    Augustine S Aruna
    College of Pharmacy, Xavier University of Louisiana, New Orleans, LA 70125 1098, USA
    Ann Pharmacother 39:1131-5. 2005
    To report a case of neuroleptic malignant syndrome (NMS) associated with fluphenazine in a schizophrenic patient and review the literature related to this condition.
  57. ncbi Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach
    H Kirchherr
    Medical Laboratory Bremen, Haferwende 12, D 28359 Bremen, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 843:100-13. 2006
    ..chlorprothixene, citalopram, clomipramine, clozapine, desipramine, doxepin, fluoxetine, flupentixol, fluphenazine, fluvoxamine, haloperidol, hydroxyrisperidone, imipramine, levomepromazine, maprotiline, mianserine, ..
  58. ncbi Efficacy of typical and atypical antipsychotics for primary and comorbid anxiety symptoms or disorders: a review
    Keming Gao
    Department of Psychiatry, the Bipolar Disorders Research Center, University Hospitals of Cleveland Case Western Reserve University, School of Medicine, Cleveland, Ohio, USA
    J Clin Psychiatry 67:1327-40. 2006
    ..The efficacy of antipsychotics in the treatment of primary or comorbid anxiety disorders or anxiety symptoms in major depressive disorder or bipolar disorder was reviewed...
  59. ncbi Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II
    Shu Feng Zhou
    School of Health Sciences, RMIT University, Melbourne, Victoria, Australia
    Clin Pharmacokinet 48:761-804. 2009
    ..drug monitoring has been strongly recommended for many antipsychotics, including haloperidol, chlorpromazine, fluphenazine, perphenazine, risperidone and thioridazine, which are all metabolized by CYP2D6...
  60. ncbi Bacitracin-sensitive aminopeptidase(s) degradation of methionine(5)-enkephalin by human brain putamen and hippocampus preparations: inhibition by phenothiazine drugs
    Aron D Mosnaim
    Department of Cellular and Molecular Pharmacology, The Chicago Medical School at Rosalind Franklin University, North Chicago, IL 60064, USA
    Am J Ther 16:512-6. 2009
    ..t1/2) and initial velocity (Iv) of this reaction were significantly increased and decreased, respectively, by fluphenazine > prochlorpherazine > chlorpromazine > thioridazine > promethazine > ethopropazine; brain A ..
  61. pdf Atypical antipsychotics: mechanism of action
    Philip Seeman
    Departments of Pharmacology and Psychiatry, University of Toronto, Toronto, Ontario
    Can J Psychiatry 47:27-38. 2002
    ..To understand how these drugs work, it is important to examine the atypical antipsychotics' mechanism of action and how it differs from that of the more typical drugs...
  62. ncbi A simple and reliable procedure for the determination of psychoactive drugs in oral fluid by gas chromatography-mass spectrometry
    Mitona Pujadas
    Grup de Recerca Clínica en Farmacologia Humana i Neurociencies, Unitat de Farmacologia, Institut Municipal d Investigacio Medica, Dr Aiguader 88, 08003 Barcelona, Spain
    J Pharm Biomed Anal 44:594-601. 2007
    ..drugs (amitryptiline, paroxetine and sertraline), antipsychotic drugs (haloperidol, chlorpromazine and fluphenazine) chlormethiazole, loratidine, hydroxyzine, diphenhydramine, valproic acid and gabapentin...
  63. ncbi In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure
    Aron D Mosnaim
    Department of Cellular and Molecular Pharmacology, Finch University of Health Sciences, Chicago Medical School, Chicago, Ill, USA
    Pharmacology 67:6-13. 2003
    ..Half-life peptide degradation was significantly increased by thioridazine > fluphenazine > As-1397 [10-(alpha-diethylaminopropionyl)phenothiazine] >/= promethazine >/= chlorpromazine (final ..
  64. ncbi Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors
    K Herrick-Davis
    Center for Neuropharmacology and Neuroscience, Albany Medical College, Albany, New York, USA
    J Pharmacol Exp Ther 295:226-32. 2000
    ..drugs (chlorpromazine, loxapine, thioridazine, prochlorperazine, perphenazine, mesoridazine, trifluperidol, fluphenazine, spiperone, haloperidol, pimozide, penfluridol, thiothixene) were devoid of inverse agonist activity, with the ..
  65. ncbi Hospitalization risk associated with typical and atypical antipsychotic use in community-dwelling elderly patients
    Rajender R Aparasu
    Department of Clinical Sciences and Administration, College of Pharmacy, University of Houston, Texas Medical Center, Houston, Texas 77030, USA
    Am J Geriatr Pharmacother 6:198-204. 2008
    ..However, few studies have examined the impact of typical and atypical antipsychotic use on all-cause hospitalization in the elderly population...
  66. ncbi The association between class of antipsychotic and rates of hospitalization: results of a retrospective analysis of data from the 2005 Medicare current beneficiary survey
    Jae Kennedy
    Department of Health Policy and Administration, Washington State University, Pullman, Washington 99210 1495, USA
    Clin Ther 31:2931-9. 2009
    ..This presumably would reduce the need for hospital services. However, health research to test this hypothesis has focused mostly on psychiatric readmissions...
  67. ncbi Trypanosoma cruzi dihydrolipoamide dehydrogenase as target for phenothiazine cationic radicals. Effect of antioxidants
    José Gutiérrez-Correa
    Instituto de Medicina Tropical Daniel A Carrión, Facultad de Medicina, Universidad Nacional Mayor de San Marcos, Lima, Peru
    Curr Drug Targets 7:1155-79. 2006
    ..inactivating agents, whereas trifluophenothiazines with CF3 group at 2-position (Trifluoperazine (TFP), fluphenazine (FFZ) and trifluopromazine (TFPZ)), and propericyazine (PCYZ) with CN group at 2-position, were much less ..
  68. ncbi Evaluation of Peakmaster for computer-aided multivariate optimisation of a CE separation of 17 antipsychotic drugs using minimal experimental data
    Kara F Johns
    Australian Centre for Research on Separation Science, School of Chemistry, University of Tasmania, Hobart, Tasmania, Australia
    Electrophoresis 30:839-47. 2009
    ..of 17 antipsychotic drugs (chlorpromazine hydrochloride, clozapine, droperidol, flupenthixol dihydrochloride, fluphenazine dihydrochloride, haloperidol, pimozide, thioridazine hydrochloride, trifluoperazine dihydrochloride, ..
  69. ncbi Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography
    Einosuke Tanaka
    Department of Legal Medicine, Institute of Community Medicine, University of Tsukuba, Tsukuba shi, Ibaraki ken 305 8575, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 854:116-20. 2007
    ..method has been developed for the simultaneous analysis of the 12 phenothiazines (chlorpromazine, fluphenazine, levomepromazine, perazine, perphenazine, prochlorperazine, profenamine, promethazine, propericiazine, ..
  70. ncbi Effects of psychotropic drugs on seizure threshold
    Francesco Pisani
    Department of Neurosciences and of Psychiatric and Anaesthesiological Sciences, First Neurological Clinic, The University of Messina, Messina, Italy
    Drug Saf 25:91-110. 2002
    ..tranylcypromine, fluoxetine, paroxetine, sertraline, venlafaxine and trazodone among antidepressants and fluphenazine, haloperidol, pimozide and risperidone among antipsychotics that exhibit a relatively low risk...
  71. ncbi An evaluation of protein assays for quantitative determination of drugs
    Katherine M Williams
    Analytical Biochemistry Group, Sunderland Pharmacy School, School of Health, Natural and Social Sciences, Fleming Building, The University of Sunderland SR1 3RG, Sunderland, UK
    J Biochem Biophys Methods 57:45-55. 2003
    ..amoxicillin, ampicillin, gentamicin, neomycin, penicillin G and vancomycin), antipsychotics (chlorpromazine, fluphenazine, prochlorperazine, promazine and thioridazine) and water-soluble vitamins (ascorbic acid, niacinamide, ..
  72. ncbi Pharmacological options for the treatment of Tourette's disorder
    F J Jimenez-Jimenez
    Department of Medicine Neurology, Hospital Principe de Asturias, Universidad de Alcala, Alcala De Henares Madrid, and Neuro Magister S L Company, Madrid, Spain
    Drugs 61:2207-20. 2001
    ..of atypical antipsychotic drugs (risperidone, olanzapine, clozapine, ziprasidone) and other dopaminergic drugs (fluphenazine, sulpiride, tiapride, metoclopramide, piquindone, tetrabenazine), clonazepam, calcium channel antagonists, ..
  73. ncbi Use and safety of antipsychotic drugs during pregnancy
    Adrienne Einarson
    Motherisk Program, Division of Clinical Pharmacology, The Hospital for Sick Children, University of Toronto, Canada
    J Psychiatr Pract 15:183-92. 2009
    ..prochlorperazine, haloperidol, perphenazine, trifluoperazine, loxapine, thioridazine, flupenthixol, fluphenazine) and second-generation antipsychotics (eg, clozapine, risperidone, olanzapine, quetiapine, ziprasidone, ..
  74. ncbi Ocular hypotension induced by topical dopaminergic drugs and phosphodiesterase inhibitors
    C Hariton
    CIBA Vision Ophthalmics, International Ophtha R and D, Bülach, Switzerland
    Eur J Pharmacol 258:85-94. 1994
    ..Significant ocular hypotensive activity was observed after topical application of trifluperidol, fluphenazine, thiothixene, and the S(-) enantiomer of 3-(3-hydroxyphenyl)-N-n-propylpiperidine (3-PPP)...
  75. ncbi Effect of anti-calmodulin drugs on the growth and sensitivity of C6 rat glioma cells to bleomycin
    W N Hait
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06510
    Anticancer Res 14:1711-21. 1994
    ..0x), 4-chlorpromazine (3.4x), thiomethylpromazine (3.3x), didesmethylchlorpromazine (11x), fluphenazine (5.5x) and trifluoperazine (3.2x)...
  76. ncbi Effects of vesicular acetylcholine uptake blockers on frequency augmentation-potentiation in frog neuromuscular transmission
    T Maeno
    Department of Physiology, Shimane Medical University, Izumo, Japan
    Neuroscience 59:487-93. 1994
    ..2-(4-benzylpiperidino)cyclohexanol, had strong effects, while those of aminacrine, chlorpromazine, fluphenazine, imipramine, pyrilamine and thioridazine were weak...
  77. ncbi Inhibition of glucose transport in PC12 cells by the atypical antipsychotic drugs risperidone and clozapine, and structural analogs of clozapine
    T D Ardizzone
    Department of Pharmacology, LSU Health Sciences Center, 1501 Kings Hwy, Shreveport, LA 71130, USA
    Brain Res 923:82-90. 2001
    ..Moreover, clozapine and fluphenazine inhibited glucose transport in the rat muscle cell line, L6...
  78. ncbi Characterisation of dopamine receptors in insect (Apis mellifera) brain
    I C Kokay
    Department of Zoology, University of Otago, Dunedin, New Zealand
    Brain Res 706:47-56. 1996
    ..rank order of potency for antagonists was: R(+)-SCH23390 > cis-(Z)-flupentixol > or = chlorpromazine > fluphenazine > S(+)-butaclamol > spiperone. R(+/-)-SKF38393 and dopamine were the most effective agonists tested...
  79. ncbi Invertebrate compounds acting on the hemostatic mechanism
    C L Arocha-Pinango
    Centro de Medicina Experimental, Instituto Venezolano de Investigaciones Cientificas, Caracas, Venezuela
    Blood Coagul Fibrinolysis 10:43-68. 1999
    ..Some of these components have been well characterized, cloned and prepared in recombinant form, and seem to be very promising from the therapeutic point of view...
  80. ncbi Induction patterns of Fos-like immunoreactivity in the forebrain as predictors of atypical antipsychotic activity
    G S Robertson
    Department of Pharmacology, Faculty of Medicine, University of Ottawa, Ontario, Canada
    J Pharmacol Exp Ther 271:1058-66. 1994
    ..with a clearly documented liability for producing extrapyramidal side effects (EPS) such as chlorpromazine, fluphenazine, haloperidol, loxapine, metoclopramide and molindone elevated FLI in the dorsolateral striatum...
  81. ncbi Effects of dopamine receptor agonists and antagonists on catecholamine release in bovine chromaffin cells
    P Huettl
    Department of Pharmacology, University of Colorado Health Sciences Center, Denver
    J Pharmacol Exp Ther 257:567-74. 1991
    ..M concentrations of the selective dopamine D2 receptor antagonists haloperidol, domperidone, metaclopramide, fluphenazine, flupentixol, (+)- or (-)-sulpiride, the dopamine D1 receptor antagonist SCH 23390 (10(-7) M) or the alpha ..
  82. ncbi Changes in CArG-binding protein A expression levels following injection(s) of the D1-dopamine agonist SKF-82958 in the intact and 6-hydroxydopamine-lesioned rat
    W J Rushlow
    Department of Anatomy and Cell Biology, The University of Western Ontario, Ontario, London, Canada
    Neuroscience 98:69-78. 2000
    ..levels in the lateral caudate-putamen of rats treated acutely and chronically with the D2 receptor antagonist fluphenazine (phenothiozine typical psychotic)...
  83. pmc Susceptibilities of Candida albicans multidrug transporter mutants to various antifungal agents and other metabolic inhibitors
    D Sanglard
    Institut de Microbiologie, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland
    Antimicrob Agents Chemother 40:2300-5. 1996
    ..agents (terbinafine and amorolfine) and to different metabolic inhibitors (cycloheximide, brefeldin A, and fluphenazine)...
  84. ncbi Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Oncol Rep 15:107-12. 2006
    ..The following phenothiazines were evaluated: perphenazine, fluphenazine, thioridazine trifluoperazine and chlorpromazine...
  85. ncbi Intramuscular preparations of antipsychotics: uses and relevance in clinical practice
    A Cario Altamura
    Department of Psychiatry, Department of Clinical Sciences Luigi Sacco, University of Milan, Via G B Grassi 74, Milan 20157, Italy
    Drugs 63:493-512. 2003
    ..Efficacy, pharmacodynamics and clinical pharmacokinetics of haloperidol decanoate, fluphenazine enanthate and decanoate, clopenthixol decanoate, zuclopenthixol decanoate and acutard, flupenthixol decanoate, ..
  86. ncbi Tourette syndrome: clinical characteristics and current management strategies
    E H Kossoff
    Department of Paediatrics, The Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Paediatr Drugs 3:355-63. 2001
    ..Should these agents be ineffective, we would recommend pimozide, fluphenazine, risperidone or haloperidol...
  87. ncbi Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence
    Dominique Sanglard
    Institute of Microbiology, Centre Hospitalier Universitaire Vaudois CHUV, Rue du Bugnon 44, CH 1011 Lausanne, Switzerland
    Mol Microbiol 48:959-76. 2003
    ..terbinafine, amorolfine) and to several other metabolic inhibitors (caffeine, brefeldin A, mycophenolic acid, fluphenazine) or cell wall-perturbing agents (SDS, calcofluor white, Congo red), thus indicating that the calcineurin ..
  88. ncbi Bait-delivered pimozide causes precocious embryo implantation in mink: a fertility control option for the exotic stoat?
    Clive A Marks
    Nocturnal Wildlife Research, PO Box 2126, Wattletree Road RPO, East Malvern, VIC 3145, Australia
    Reprod Fertil Dev 18:703-8. 2006
    ..A bait dose of 0.8 mg kg(-1) of pimozide was more effective in elevating PRL levels than equivalent doses of fluphenazine, sulpiride (P < 0.01) or haloperidol (P < 0.05). Bait doses of 1...
  89. ncbi Risperidone. A pharmacoeconomic review of its use in schizophrenia
    R H Foster
    Adis International Limited, Auckland, New Zealand
    Pharmacoeconomics 14:97-133. 1998
    ..and a cost-utility study that compared the drug with oral haloperidol, depot haloperidol decanoate and depot fluphenazine decanoate for 1 year's treatment of an initially hospitalised chronic schizophrenic patient with moderate ..
  90. ncbi New treatments for tic disorders
    Mohammad M Qasaymeh
    Child Neurology, Box 631, University of Rochester Medical Center, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Curr Treat Options Neurol 8:465-73. 2006
    ..Thus, standard antipsychotic medications such as haloperidol, pimozide, or fluphenazine are the most potent. However, these medications commonly cause bothersome side effects...
  91. ncbi Modulation of emesis by fentanyl and opioid receptor antagonists in Suncus murinus (house musk shrew)
    J A Rudd
    Department of Pharmacology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, N T
    Eur J Pharmacol 374:77-84. 1999
    ..p.), 8-OH-DPAT, ((+/-)-8-hydroxy-dipropylaminotetralin; 0.003-0.3 mg/kg, s.c.), buspirone (3 mg/kg, s.c.) and fluphenazine (1-3 mg/kg, i.p.) but not by naltrexone (1-30 mg/kg, s.c.), metoclopramide (0.3-3 mg/kg, i.p.), sulpiride (0...
  92. ncbi Possible malignant neuroleptic syndrome that associated with hypothyroidism
    Cagatay Taskapan
    Department of Biochemistry, Inonu University Faculty of Medicine, Turgut Ozal Medical Center, 44069 Malatya, Turkey
    Prog Neuropsychopharmacol Biol Psychiatry 29:745-8. 2005
    ..She had been given fluphenazine decanoete 20 mg intramuscularly 15 days before the admission and she had continued taking haloperidol 20 mg ..
  93. ncbi Sperm protamine levels as indicators of fertilising potential in sexually mature male rats
    M Aleem
    Department of Urology, Medical College of Ohio, Toledo, OH, USA
    Andrologia 40:29-37. 2008
    We have earlier reported that administration of cyproterone acetate, fluphenazine decanoate, tamoxifen citrate, oestradiol valerate to adult male rats, at doses of 50, 5.77, 0.71, 0...
  94. pmc Sequencing, disruption, and characterization of the Candida albicans sterol methyltransferase (ERG6) gene: drug susceptibility studies in erg6 mutants
    K L Jensen-Pergakes
    Department of Biology, Indiana University Purdue University Indianapolis, 46202 5132, USA
    Antimicrob Agents Chemother 42:1160-7. 1998
    ..to a number of sterol synthesis and metabolic inhibitors, including terbinafine, tridemorph, fenpropiomorph, fluphenazine, cycloheximide, cerulenin, and brefeldin A. No increase in susceptibility to azoles was noted...
  95. ncbi Inhibition of cytochrome P450 enzymes participating in p-nitrophenol hydroxylation by drugs known as CYP2E1 inhibitors
    Katalin Monostory
    Department of Biochemical Pharmacology, Chemical Research Center, Hungarian Academy of Sciences, P O Box 17, Pusztaszeri ut 59 67, H 1025 Budapest, Hungary
    Chem Biol Interact 147:331-40. 2004
    ..bifonazole, econazole, clotrimazole, ketoconazole, miconazole; CNS-active drugs: chlorpromazine, desipramine, fluphenazine, thioridazine; and the non-steroidal anti-inflammatory drug: diclofenac were investigated on the enzyme ..
  96. ncbi Excited-state properties and in vitro phototoxicity studies of three phenothiazine derivatives
    Fausto Elisei
    Department of Chemistry, University of Perugia, Italy
    Photochem Photobiol 75:11-21. 2002
    ..and photobiological study of three drugs (psychotherapeutic agents) of the phenothiazine series: perphenazine, fluphenazine hydrochloride and thioridazine hydrochloride...
  97. ncbi Phenothiazine-type antipsychotics elicit cutaneous analgesia in rats
    Yu Wen Chen
    Department of Medical Research, Chi Mei Medical Center, Tainan, Taiwan, R O C
    Acta Anaesthesiol Taiwan 48:3-7. 2010
    ..The aim of this study was to evaluate the cutaneous analgesic effect of phenothiazine-type antipsychotics...
  98. ncbi An animal model of extrapyramidal side effects induced by antipsychotic drugs: relationship with D2 dopamine receptor occupancy
    A D Crocker
    Department of Clinical Pharmacology, The Flinders University of South Australia, Bedford Park, Australia
    Prog Neuropsychopharmacol Biol Psychiatry 25:573-90. 2001
    ..muscle rigidity) in the hindlimb muscles of the rat following subcutaneous administration of haloperidol, fluphenazine and thioridazine. 2...
  99. pmc Antagonism of azole activity against Candida albicans following induction of multidrug resistance genes by selected antimicrobial agents
    K W Henry
    Department of Microbiology and Immunology, MCP Hahnemann School of Medicine, Philadelphia, Pennsylvania 19129, USA
    Antimicrob Agents Chemother 43:1968-74. 1999
    ..Zidovudine, trimethoprim, and isoniazid, which were not antagonistic with azoles, did not induce these RNAs. Fluphenazine, a known substrate for Cdr1p and Cdr2p, strongly induced their RNAs and, consistent with our hypothesis, ..
  100. pmc Anti-calmodulins and tricyclic adjuvants in pain therapy block the TRPV1 channel
    Zoltan Olah
    Institute of Biochemistry, Biological Research Center of the Hungarian Academy of Sciences, Szeged, Hungary Acheuron Hungary Ltd, Szeged, Hungary Acheuron Pharmaceuticals Inc, San Diego, California, United States of America
    PLoS ONE 2:e545. 2007
    ..calmidazolium (broad range) > or = trifluoperazine (narrow range) chlorpromazine/amitriptyline>fluphenazine>>W-7 and W-13 (only partially)...
  101. ncbi Impact of four antimutagens on apoptosis in genotoxically damaged lymphocytes in vitro
    K Gasiorowski
    Wroclaw Medical University, Department of Basic Medical Sciences, Kochanowskiego 14, 51 601 Wrocław, Poland
    Cell Mol Biol Lett 6:649-75. 2001
    An antimutagenic activity of fluphenazine, todralazine, anthocyanins and alkylresorcinols was established in a battery of short-term cytogenetic tests...

Research Grants48

  1. Neuronal specific Autophagy Signaling
    Dale M Ando; Fiscal Year: 2013
    ..Mimicking low cytosolic calcium in neurons using the calmodulin inhibitors fluphenazine and trifluoperazine leads to robust induction of mTOR- independent autophagy...
  2. 1/2-A Comparison of Long-Acting Injectable Medications for Schizophrenia -ACLAIMS
    JOSEPH PATRICK MCEVOY; Fiscal Year: 2013
    ..g., fluphenazine decanoate-- FD). No study comparing RM and FD has been conducted that justifies this premium pricing...
  3. 2/2-A Comparison of Long-Acting Injectable Medications for Schizophrenia -ACLAIMS
    THOMAS SCOTT STROUP; Fiscal Year: 2013
    ..g., fluphenazine decanoate-- FD). No study comparing RM and FD has been conducted that justifies this premium pricing...
  4. MECHANISMS OF CARDIOTOXICITY OF ANTIPSYCHOTIC DRUGS
    David Flockhart; Fiscal Year: 2001
    ..In subsequent years, the investigators will evaluate thioridazine, fluphenazine and loxapine...
  5. DOPAMINE IN NEONATAL HYPOXIC-ISCHEMIC BRAIN INJURY
    Francis Filloux; Fiscal Year: 1992
    ..of a depleter of endogenous dopamine (alpha-methyl-ptyrosine), of dopamine antagonists, both non-selective (fluphenazine and flupenthioxl) and selective (SCH 23390; sulpiride), and of antioxidants will be assessed in this model...
  6. Atypical Antipsychotics: Determinants of Concentration
    Bruce Pollock; Fiscal Year: 2004
    ..is to reliably capture the concentration exposure of the antipsychotics (risperidone, olanzapine, ziprasidone, fluphenazine, perphenazine, and clozapine) using mixed effect population pharmacokinetic methodologies...
  7. Effects of antipsychotic drugs on brain and behavior
    FRANK TARAZI; Fiscal Year: 2005
    ..Behavioral effects of representative typical (fluphenazine), atypical (clozapine) and newer (olanzapine) antipsychotic agents will be assessed in behavioral paradigms ..
  8. TARDIVE DYSKINESIA: FREE RADICAL MECHANISMS & VITAMIN E
    James Lohr; Fiscal Year: 1993
    ..alpha-tocopherol will be administered to rats treated long-term (up to one year) with the neuroleptic fluphenazine decanoate to determine if treatment with alpha-tocopherol reduces the incidence and severity of neurochemical (..
  9. FLUPHENAZINE BLOOD LEVELS, EFFICACY & PHARMACOKINETICS
    George Simpson; Fiscal Year: 1990
    A four-year renewal is proposed of a study of fluphenazine (FPZ) blood levels, efficacy and side effects during acute oral and chronic depot therapy...
  10. LATE BEHAVIOR & EEG EFFECTS OF ANTIPSYCHOTIC MEDICATION
    KENNETH LIFSHIRZ; Fiscal Year: 1990
    ..The treated monkeys will be exposed for 51 weeks to periodic injections of fluphenazine decanoate in amounts comparable to those used in treating human subjects, resulting in blood level ..
  11. Sustained Release Olanzapine
    Thomas Smith; Fiscal Year: 2004
    ..can be enhanced with long-acting, injectable preparations (currently only long-chain fatty acid esters of fluphenazine or haloperidol are licensed in the US), but no long-acting preparation has yet been licensed for a modern ..
  12. THPB-Containing Herbal Preparations for the Treatment of Drug Abuse
    John R Mantsch; Fiscal Year: 2010
    ..procedures to compare the effects of l-THP and l-SPD with those of the non-selective DA receptor antagonist, fluphenazine, and an "atypical" anti- psychotic in paradigms designed to examine the ability of these agents, when ..
  13. TREATMENT STRATEGIES IN SCHIZOPHRENIA AT GRADY
    Philip Ninan; Fiscal Year: 1992
    ..design, to look at different drug maintenance strategies (standard, low and intermittent dosages of fluphenazine decanoate) and their relationship to psychosocial management strategies (applied and supportive family therapy)...
  14. Human Cocaine Discrimination
    CRAIG RUSH; Fiscal Year: 2006
    ..1); fluphenazine, a D1-D2 dopamine receptor antagonist (Exp. 2); and haloperidol, a D2 dopamine receptor antagonist (Exp. 3)...
  15. ALPRAZOLAM - NEUROLEPTIC TREATMENT IN SCHIZOPHRENIA
    Owen Wolkowitz; Fiscal Year: 1991
    ..During the first two weeks, patients will be stabilized on fluphenazine following which either alprazolan or placebo will be added in a double-blind manner for four weeks...
  16. Changing from Conventional to Risperidone Decanoate
    Nancy Covell; Fiscal Year: 2005
    ..Should people who are relatively stable on one of the first-generation depot antipsychotic medications (fluphenazine or haloperidol) but who are still symptomatic or troubled by medication side effects be switched to long-acting ..
  17. NEW ANTIPSYCHOTIC STRATEGIES IN SCHIZOPHRENIA
    Robert Conley; Fiscal Year: 2001
    ..The study proposed in this application will test the efficacy of sertindole, quetiapine, and risperidone versus fluphenazine in this population. The drugs will be tested in a drug-drug double-blind parallel group design...
  18. PROLACTIN/FLUPHENAZINE LEVELS IN MAINTENANCE SCHIZOPHREN
    George Simpson; Fiscal Year: 1990
    A four-year study is proposed to investigate (1) the relationship between fluphenazine (FPZ) blood levels and efficacy in the treatment of acute schizophrenic exacerbations, and (2) the pharmacokinetics of oral FPZ and of FPZ decanoate...
  19. TREATMENT STRATEGIES IN SCHIZOPHRENIA
    John Kane; Fiscal Year: 1991
    ..The proposed study is part of a collaborative project sponsored by the NIMH. Patients will be stabilized on fluphenazine decanoate (FD) and then randomly assigned to one of the following treatment to continue for two years: ..
  20. TREATMENT OF NEUROLEPTIC NONRESPONSIVE SCHIZOPHRENIA
    John Kane; Fiscal Year: 1991
    ..stategies for patients who fail to meet a priori criteria for improvement following a four week course of fluphenazine HCL 20 mg/day...
  21. NEUROLEPTIC NONCOMPLIANCE IN SCHIZOPHRENIA
    Peter Weiden; Fiscal Year: 1991
    ..dysphoria, beliefs about their illness and treatment, and psychiatric symptoms during standardized open fluphenazine treatment...
  22. COCAINE AND DOPAMINE--LINKED RESPONSES
    Patrick Randall; Fiscal Year: 1993
    ..determine the extent to which quantitative predictions may be made regarding the effect of the DA antagonist, fluphenazine on the behavioral and neurochemical (extracellular cyclic amp) responses to cocaine...
  23. RESEARCH ETHICS IN SCHIZOPHRENIA
    William Carpenter; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  24. Comorbid Substance Abuse and Long-Term Health Outcomes in Schizophrenia
    DEANNA KELLY; Fiscal Year: 2008
    ..This will be an important step for improving the lives of people with schizophrenia. [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  25. Brain Development on Adults with Schizophrenia
    George Bartzokis; Fiscal Year: 2008
    ..This will change our concept of how we could treat this illness, the feasibility of changing its lifelong course, and would encourage the development of novel pharmacologic interventions to improve myelination. [unreadable] [unreadable]..
  26. MANAGEMENT FOR RISK OF RELAPSE IN SCHIZOPHRENIA
    Stephen Marder; Fiscal Year: 2004
    ..The investigator will evaluate outcome during the next two years with measures of clinical psychopathology, medication side effects, functional outcomes, and quality of life. ..
  27. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  28. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    Stephen Marder; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cycloserine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  29. TREATMENT OF NEGATIVE SYMPTOMS & COGNITIVE IMPAIRMENTS
    William Carpenter; Fiscal Year: 2003
    ..The study will provide new information on the efficacy of d- cyclosporine and glycine for both persistent primary and secondary negative symptoms and its effect on cognitive functioning. ..
  30. Medication Management Decisions in Schizophrenia
    Mark Olfson; Fiscal Year: 2003
    ..The results will inform quality improvement programs by identifying key modifiable determinants of the quality of medication management in the community treatment of schizophrenia. ..
  31. Acoustic startle reduction in cocaine dependence
    Erica Duncan; Fiscal Year: 2009
    ..abstract_text> ..
  32. Cognitive Behavioral Treatment of PTSD in SMI Clients
    Kim T Mueser; Fiscal Year: 2010
    ..The results of this research will bring the field one step closer to having an evidence-based practice for trauma and PTSD in clients with SMI. ..
  33. Clinical and Neuropsychological Investigations in Batten Disease
    Jonathan W Mink; Fiscal Year: 2010
    ..Although JNCL is a rare disease, our research has implications that can be generalized to the study of other degenerative neurologic disorders in children and for preparing translational clinical trials in these diseases. ..
  34. A Rapid Immunoassay for Detection of Yersinia Pathogens
    John Glass; Fiscal Year: 2002
    ..Furthermore, this prototype assay will be reduced to a production model, validated for regulatory approval, and finalized for manufacture through a joint venture partner. ..
  35. PATHOPHYSIOLOGY OF CHOREA
    Jonathan Mink; Fiscal Year: 2002
    ..abstract_text> ..
  36. Mapping Abnormal Neurodevelopment in Schizophrenia
    Deanna Barch; Fiscal Year: 2008
    ..unreadable] ..
  37. PREVENTING MORBIDITY IN FIRST EPISODE SCHIZOPHRENIA
    Delbert Robinson; Fiscal Year: 2008
    ..The findings will provided guidance to clinicians in the selection of the best medication for patients experiencing a first episode of illness, who have no prior treatment history to guide this choice. ..
  38. FAMILY INTERVENTION FOR SMI AND SUBSTANCE USE DISORDERS
    Kim Mueser; Fiscal Year: 2005
    ..Improvements in these areas may the have long-term benefit of maintaining family involvement with dually diagnosed clients, thereby reducing housing instability and homelessness. ..
  39. Ethanol Effects in the Mammalian Circadian Clock
    Rebecca Prosser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  40. Pharmacogenetics in Tourette Syndrom
    Harvey Singer; Fiscal Year: 2004
    ..The identification of genetic polymorphisms that are associated with clinical disease or treatment success, has obvious benefits. ..
  41. Addressing Challenges in Schizophrenia Research
    THOMAS STROUP; Fiscal Year: 2007
    ..The applicant's career will focus on designing and testing interventions to improve outcomes of persons who are severely affected by schizophrenia. ..
  42. Glutamate Signaling and Drug Abuse
    MOHAMMADHOSSEIN GHASEMZADEH; Fiscal Year: 2007
    ....
  43. Schizophenia Libility Genes among African-Americans
    Joseph McEvoy; Fiscal Year: 2006
    ..Finally, we have an outstanding track record of African American participation in research studies, and a deep appreciation of their population genetics. ..
  44. MOLECULAR BIOLOGY OF MUTANT 5-HT2C SEROTONIN RECEPTORS
    Katharine Herrick Davis; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  45. 2-Way Pagers to Improve Schizophrenia Medication Adherence
    Delbert Robinson; Fiscal Year: 2008
    ..Results of this R34 intervention development project will provide a blueprint for the optimal design of future fully powered efficacy and effectiveness trials ..