phenothiazines

Summary

Summary: Compounds containing dibenzo-1,4-thiazine. Some of them are neuroactive.

Top Publications

  1. ncbi Factors related to prescription dosage in Japanese psychiatric hospitals
    Shigeki Nawata
    Department of Health Policy and Management, School of Medicine, Keio University, Tokyo, Japan
    Psychiatry Clin Neurosci 59:70-6. 2005
  2. ncbi The in vitro activity of phenothiazines against Mycobacterium avium: potential of thioridazine for therapy of the co-infected AIDS patient
    Miguel Viveiros
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    In Vivo 19:733-6. 2005
  3. pmc Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus
    Glenn W Kaatz
    The John D Dingell Department of Veteran s Affairs Medical Center, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 47:719-26. 2003
  4. ncbi Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
    Daniel Nagel
    Research Unit Cellular Signal Integration, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Molecular Toxicology and Pharmacology, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Cancer Cell 22:825-37. 2012
  5. ncbi Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
    Sayuri Taniguchi
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Biol Chem 280:7614-23. 2005
  6. ncbi Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods
    P B Kandagal
    Department of Chemistry, Karnatak University, Dharwad, India
    J Pharm Biomed Anal 47:260-7. 2008
  7. ncbi Evolutionary redeployment of a biosynthetic module: expression of eye pigment genes vermilion, cinnabar, and white in butterfly wing development
    Robert D Reed
    Department of Biology, Duke University, Durham, NC, USA
    Evol Dev 7:301-11. 2005
  8. ncbi Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus
    Diane Ordway
    Unit of Mycobacteriology, Department of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    Int J Antimicrob Agents 20:34-43. 2002
  9. ncbi Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines
    Leonard Amaral
    Grupo de Micobacterias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349 008 Lisboa, Portugal
    Int J Antimicrob Agents 38:140-5. 2011
  10. ncbi Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2)
    Takahiro Yano
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:11456-63. 2006

Research Grants

  1. O-RECEPTOR PSYCHOTOMIMETICS: ACTIONS ON SINGLE NEURONS
    John Williams; Fiscal Year: 1992
  2. BIOCHEMISTRY OF EXCITABLE MEMBRANES
    BRUCE KRUEGER; Fiscal Year: 1991
  3. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
  4. Effect of Urban Form on Exercise and BMI in Black Women
    Patricia Coogan; Fiscal Year: 2009
  5. Mood Disorders & Diabetes: Common Disease Mechanisms
    WILLIAM REGENOLD; Fiscal Year: 2005
  6. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
  7. STRUCTURE AND GENESIS OF TAU FILAMENTS
    Jeff Kuret; Fiscal Year: 2009
  8. STRUCTURE, FUNCTION, AND REGULATION OF CASEIN KINASE-1
    Jeff Kuret; Fiscal Year: 2001
  9. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
  10. Materials for Sensing & Actuation
    Sylvia Daunert; Fiscal Year: 2004

Detail Information

Publications208 found, 100 shown here

  1. ncbi Factors related to prescription dosage in Japanese psychiatric hospitals
    Shigeki Nawata
    Department of Health Policy and Management, School of Medicine, Keio University, Tokyo, Japan
    Psychiatry Clin Neurosci 59:70-6. 2005
    ..Doses in the butyrophenone category were related to pathological experiences and that in the phenothiazine category to behavioral aspects...
  2. ncbi The in vitro activity of phenothiazines against Mycobacterium avium: potential of thioridazine for therapy of the co-infected AIDS patient
    Miguel Viveiros
    Unit of Mycobacteriology, UPMM, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    In Vivo 19:733-6. 2005
    ..avium to most non-toxic compounds. Therefore, the need for effective agents is obvious. Because phenothiazines, especially the relatively mild thioridazine, have significant activity against Mycobacterium tuberculosis, we ..
  3. pmc Phenothiazines and thioxanthenes inhibit multidrug efflux pump activity in Staphylococcus aureus
    Glenn W Kaatz
    The John D Dingell Department of Veteran s Affairs Medical Center, Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    Antimicrob Agents Chemother 47:719-26. 2003
    ..The inhibitory effects of selected phenothiazines and two geometric stereoisomers of the thioxanthene flupentixol were studied using strains of S...
  4. ncbi Pharmacologic inhibition of MALT1 protease by phenothiazines as a therapeutic approach for the treatment of aggressive ABC-DLBCL
    Daniel Nagel
    Research Unit Cellular Signal Integration, Helmholtz Zentrum Munchen German Research Center for Environmental Health, Institute of Molecular Toxicology and Pharmacology, Ingolstadter Landstrasse 1, 85764 Neuherberg, Germany
    Cancer Cell 22:825-37. 2012
    ..We have identified distinct derivatives of medicinal active phenothiazines, namely mepazine, thioridazine, and promazine, as small molecule inhibitors of the MALT1 protease...
  5. ncbi Inhibition of heparin-induced tau filament formation by phenothiazines, polyphenols, and porphyrins
    Sayuri Taniguchi
    Department of Molecular Neurobiology, Tokyo Institute of Psychiatry, Tokyo Metropolitan Organization for Medical Research, 2 1 8 Kamikitazawa, Setagaya Ku, Tokyo 156 8585, Japan
    J Biol Chem 280:7614-23. 2005
    ..Several phenothiazines (methylene blue, azure A, azure B, and quinacrine mustard), polyphenols (myricetin, epicatechin 5-gallate, ..
  6. ncbi Mechanism of interaction between human serum albumin and N-alkyl phenothiazines studied using spectroscopic methods
    P B Kandagal
    Department of Chemistry, Karnatak University, Dharwad, India
    J Pharm Biomed Anal 47:260-7. 2008
    The binding characteristics of human serum albumin (HSA) with N-alkyl phenothiazines derivatives (NAP) viz...
  7. ncbi Evolutionary redeployment of a biosynthetic module: expression of eye pigment genes vermilion, cinnabar, and white in butterfly wing development
    Robert D Reed
    Department of Biology, Duke University, Durham, NC, USA
    Evol Dev 7:301-11. 2005
    ..cardui...
  8. ncbi Intracellular activity of clinical concentrations of phenothiazines including thioridiazine against phagocytosed Staphylococcus aureus
    Diane Ordway
    Unit of Mycobacteriology, Department of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 019 Lisboa, Portugal
    Int J Antimicrob Agents 20:34-43. 2002
    ..These results suggest that TZ induces intracellular bactericidal activities independent of the capacity to generate Type 1 responses against S. aureus...
  9. ncbi Ethidium bromide efflux by Salmonella: modulation by metabolic energy, pH, ions and phenothiazines
    Leonard Amaral
    Grupo de Micobacterias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 100, 1349 008 Lisboa, Portugal
    Int J Antimicrob Agents 38:140-5. 2011
    ..Similarly, thioridazine, an inhibitor of metabolic enzymes, inhibits efflux of EtBr only at pH 8 and the degree of inhibition is lessened by the presence of metabolic energy...
  10. ncbi Steady-state kinetics and inhibitory action of antitubercular phenothiazines on mycobacterium tuberculosis type-II NADH-menaquinone oxidoreductase (NDH-2)
    Takahiro Yano
    Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Biol Chem 281:11456-63. 2006
    ..using a Mycobacterium smegmatis expression system, and the steady-state kinetics and inhibitory actions of phenothiazines were characterized...
  11. ncbi Multiple non-psychiatric effects of phenothiazines: a review
    Gangopadhyay Sudeshna
    Department of Life Science and Biotechnology, Jadavpur University, Kolkata, West Bengal, India
    Eur J Pharmacol 648:6-14. 2010
    ..Appropriate clinical application of phenothiazines can be developed in the future after gaining a comprehensive knowledge about their function...
  12. ncbi Phenothiazines suppress proliferation and induce apoptosis in cultured leukemic cells without any influence on the viability of normal lymphocytes. Phenothiazines and leukemia
    Zhivko Zhelev
    National Institute for Advanced Industrial Science and Technology, AIST Shikoku, 2217 14 Hayashi Cho, 761 0395 Takamatsu, Kagawa, Japan
    Cancer Chemother Pharmacol 53:267-75. 2004
    The purpose of the present study was to investigate the effects of phenothiazines (at clinically relevant doses) on the viability and proliferation of leukemic cell lines and normal lymphocytes, and to investigate the possibility of ..
  13. ncbi The functional morphology of color changing in a spider: development of ommochrome pigment granules
    Teresita C Insausti
    Institut de Recherche sur la Biologie de l Insecte, UMR CNRS 6035, Universite de Tours, Avenue Monge, Parc Grandmont, Tours, France
    J Exp Biol 211:780-9. 2008
    ..Extended studies on the ultrastructural modification and physiological processes associated with color change are required before any statement about the adaptiveness of the color change can be made...
  14. ncbi Turnover of pigment granules: cyclic catabolism and anabolism of ommochromes within epidermal cells
    T C Insausti
    Universite de Tours, Institut de Recherche sur la Biologie de l Insecte, UMR CNRS 6035, Tours, France
    Tissue Cell 41:421-9. 2009
    ..The presence of this turnover for melanins is discussed...
  15. ncbi Molecular modeling of phenothiazines and related drugs as multidrug resistance modifiers: a comparative molecular field analysis study
    I Pajeva
    Center of Biomedical Engineering, Bulgarian Academy of Sciences, BG 1113 Sofia, Bulgaria
    J Med Chem 41:1815-26. 1998
    A set of 40 phenothiazines, thioxanthenes, and structurally related drugs with multidrug resistance modulating activity in tumor cells in vitro were selected from literature data and subjected to three-dimensional quantitative structure-..
  16. ncbi Phenothiazines, bacterial efflux pumps and targeting the macrophage for enhanced killing of intracellular XDRTB
    Leonard Amaral
    Unit of Mycobacteriology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua Junqueira 96, 1349 008 Lisbon, Portugal
    In Vivo 24:409-24. 2010
    b>Phenothiazines have their primary effects on the plasma membrane of prokaryotes and eukaryotes...
  17. ncbi Cancer chemopreventive effect of phenothiazines and related tri-heterocyclic analogues in the 12-O-tetradecanoylphorbol-13-acetate promoted Epstein-Barr virus early antigen activation and the mouse skin two-stage carcinogenesis models
    Magnus A Azuine
    Laboratory of Natural Drug Products, Department of Pharmaceutical Sciences, School of Pharmacy, Howard University, 2300 4th Street, NW, Washington, DC 20059, USA
    Pharmacol Res 49:161-9. 2004
    In continuation of our search for novel agents, we have investigated 29 phenothiazines and related tri-heterocyclic compounds as potential cancer chemopreventive agents in a short-term in vitro assay of Epstein-Barr virus early antigen (..
  18. pmc In vitro differential sensitivity of melanomas to phenothiazines is based on the presence of codon 600 BRAF mutation
    Ogechi N Ikediobi
    Genomics and Bioinformatics Group, Laboratory of Molecular Pharmacology, National Cancer Institute, Bethesda, Maryland, USA
    Mol Cancer Ther 7:1337-46. 2008
    ..b>Phenothiazines have been used as antipsychotics and as adjunct antiemetics during cancer chemotherapy and more recently have ..
  19. ncbi Phenothiazines: an alternative to conventional therapy for the initial management of suspected multidrug resistant tuberculosis. A call for studies
    L Amaral
    Department of Clinical Microbiology, Sonderborg Sygehus, Sonderborg, Denmark
    Int J Antimicrob Agents 14:173-6. 2000
    ..tuberculosis may be helpful until antibiotic susceptibility is known. Phenothiazines such as chlorpromazine, methdilazine and thioridazine are effective against strains of M...
  20. ncbi Phenothiazines: potential alternatives for the management of antibiotic resistant infections of tuberculosis and malaria in developing countries
    L Amaral
    Unit of Mycobacteriology, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisboa, Portugal
    Trop Med Int Health 6:1016-22. 2001
    The in vitro and in vivo activity of phenothiazines against antibiotic susceptible and antibiotic resistant Mycobacterium tuberculosis and malaria-causing Plasmodia is reviewed...
  21. ncbi Effects of cyamemazine on hERG, INa, ICa, Ito, Isus and IK1 channel currents, and on the QTc interval in guinea pigs
    William Crumb
    Zenas Technologies, New Orleans, LA, USA
    Eur J Pharmacol 532:270-8. 2006
    ..These non-clinical findings confirm the excellent cardiac safety records of cyamemazine during its 30 years of extensive therapeutic use...
  22. ncbi Direct modification of bioactive phenothiazines by exposure to laser radiation
    Mihail Lucian Pascu
    National Institute for Laser, Plasma and Radiation Physics, Laser Department, PO Box MG 36, Str Atomistilor nr 409, Magurele, Ilfov, Bucharest 077125, Romania
    Recent Pat Antiinfect Drug Discov 6:147-57. 2011
    ..Because the laser beam energy is greater than that produced by the incoherent UV sources, exposure of phenothiazines to specific lasers may yield molecules with altered activities over that of the unexposed parent...
  23. ncbi Enhancement of vancomycin activity by phenothiazines against vancomycin-resistant Enterococcus faecium in vitro
    Mohammad Rahbar
    Department of Microbiology, Reference Health Laboratories, Ministry of Health, Tehran, Iran
    Basic Clin Pharmacol Toxicol 107:676-9. 2010
    ..inhibitory concentrations (MIC) of the compounds were determined by agar dilution method, and synergy between phenothiazines and vancomycin was investigated using Checkerboard (microbroth dilution) technique...
  24. ncbi Cyamemazine metabolites: effects on human cardiac ion channels in-vitro and on the QTc interval in guinea pigs
    William Crumb
    Zenas Technologies, New Orleans, LA, USA
    J Pharm Pharmacol 60:1507-13. 2008
    ..These non-clinical findings explain the excellent cardiac safety records of cyamemazine during its 30 years of extensive therapeutic use...
  25. ncbi Antimicrobial activity of phenothiazines
    Leonard Amaral
    Unit of Mycobacteriology UPMM Instituto de Higiene e Medicina Tropical Universidade de Lisboa, 1394 008 Lisbon, Portugal
    In Vivo 18:725-31. 2004
    ..provides the scientific and medical basis that support the use of one particular group of compounds, the phenothiazines, and in particular thioridazine, for the management of the above antibiotic-resistant infections...
  26. pmc Inauhzin and Nutlin3 synergistically activate p53 and suppress tumor growth
    Yiwei Zhang
    Department of Biochemistry and Molecular Biology and Tulane Cancer Center, Tulane University School of Medicine, New Orleans, LA, USA
    Cancer Biol Ther 13:915-24. 2012
    ..Our study provides evidence supporting this concept for achieving better therapeutic efficacy in tumors that possess wild type p53...
  27. pmc Photodegradation of 2-chloro substituted phenothiazines in alcohols
    CARMELO GARCIA
    Department of Chemistry, Humacao Campus, University of Puerto Rico, Humacao, Puerto Rico
    Photochem Photobiol 85:160-70. 2009
    ..To better understand the relationship between the molecular structure of halogenated phenothiazines and their phototoxic activity, their photophysics and photochemistry were studied in several alcohols...
  28. pmc Chemosensitization by phenothiazines in human lung cancer cells: impaired resolution of γH2AX and increased oxidative stress elicit apoptosis associated with lysosomal expansion and intense vacuolation
    D Zong
    Department of Oncology and Pathology, Karolinska Biomics Center, Karolinska Institutet, Stockholm, Sweden
    Cell Death Dis 2:e181. 2011
    ..The potential of using phenothiazines as chemosensitizers has been suggested earlier but so far our understanding of their molecular targets remains ..
  29. ncbi Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease
    Justyna B Mocko
    Department of Pathobiochemistry, University Medical Center of the Johannes Gutenberg University, Duesbergweg 6, 55099 Mainz, Germany
    Neurobiol Dis 40:120-9. 2010
    ..Thus, dopaminergic toxicity of rotenone and MPP(+)in vivo can be forestalled by nanomolar concentrations of certain chain-breaking antioxidants irrespective of dopamine receptor modulation or mitochondrial targeting...
  30. pmc A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
    Qi Zhang
    Department of Biochemistry and Molecular Biology and Cancer Center, Tulane University School of Medicine, Louisiana, LA, USA
    EMBO Mol Med 4:298-312. 2012
    ..Hence, our study unearths INZ as a novel anti-cancer therapeutic candidate that inhibits SIRT1 activity and activates p53...
  31. ncbi Acute massive pulmonary thromboembolism associated with risperidone and conventional phenothiazines
    Yoshito Kamijo
    Department of Emergency and Critical Care Medicine, School of Medicine, Kitasato University, Sagamihara, Kanagawa, Japan
    Circ J 67:46-8. 2003
    ..More women than men were affected. In 5 cases, chlorpromazine and other phenothiazines had been prescribed, whereas in 2 cases, risperidone, a mixed serotonin 5HT(2A) and dopamine D(2) receptor ..
  32. ncbi Electrophoretic separations of twelve phenothiazines and N-demethyl derivatives by using capillary zone electrophoresis and micellar electrokinetic chromatography with non ionic surfactant
    D C Le
    UMR 6180 Chirotechnologies Catalyse et Biocatalyse, Université Aix Marseille III, Faculté des Sciences et Techniques St Jérôme, 13397 Marseille Cedex 07, France
    J Chromatogr A 1063:235-40. 2005
    We focused our work on the separation of phenothiazines that are important drugs used for the treatment of psychic diseases...
  33. ncbi Determination of selected phenothiazines in human plasma by solid-phase extraction and liquid chromatography with coulometric detection
    Maria Addolorata Saracino
    Laboratory of Pharmaco Toxicological Analysis, Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Bologna, Via Belmeloro 6, I 40126 Bologna, Italy
    Anal Chim Acta 624:308-16. 2008
    ..chromatography with coulometric detection, has been developed and applied to the determination of selected phenothiazines (chlorpromazine, promazine, fluphenazine and levomepromazine) in human plasma...
  34. pmc Photodynamic inactivation of Bacillus spores, mediated by phenothiazinium dyes
    Tatiana N Demidova
    Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA 02114, USA
    Appl Environ Microbiol 71:6918-25. 2005
    ..The relatively mild conditions needed for spore killing could have applications for treating wounds contaminated by anthrax spores, for which conventional sporicides would have unacceptable tissue toxicity...
  35. ncbi Extractive-spectrophotometric determination of some phenothiazines with dipicrylamine and picric acid
    Ewa Regulska
    Department of Chemistry, Technical University of Bialystok, Zamenhofa 29, 15 435, Bialystok, Poland
    J Pharm Biomed Anal 27:335-40. 2002
    ..The relative standard deviation (RSD) is less than 0.8%...
  36. pmc DNA adopts normal B-form upon incorporation of highly fluorescent DNA base analogue tC: NMR structure and UV-Vis spectroscopy characterization
    K Cecilia Engman
    Department of Chemistry, Goteborg University, PO Box 462, SE 40530 Gothenburg, Sweden
    Nucleic Acids Res 32:5087-95. 2004
    ..This first example of an artificial, highly fluorescent DNA base that does not perturb the DNA conformation could have valuable applications for the study of the structure and dynamics of nucleic acid systems...
  37. ncbi Risk of ovarian cancer according to use of antidepressants, phenothiazines, and benzodiazepines (United States)
    P F Coogan-
    Slone Epidemiology Unit, Boston University School of Medicine, Brookline, MA 02446, USA
    Cancer Causes Control 11:839-45. 2000
    ....
  38. ncbi Consideration of use of phenothiazines in particular trifluorperazine for epidermal growth factor receptor associated cancers
    Richard E Kast
    Department of Psychiatry, College of Medicine, University of Vermont, 2 Church Street, Burlington, VT 05401, United States
    Med Hypotheses 69:1074-5. 2007
    Papers from a generation ago suggested that phenothiazines--in particular trifluorperazine (Stelazine) a medicinal approved by the FDA and still commonly used for schizophrenia--downregulate the epidermal growth factor receptor...
  39. ncbi Phenothiazines induce apoptosis in a B16 mouse melanoma cell line and attenuate in vivo melanoma tumor growth
    Irit Gil-Ad
    Laboratory of Biological Psychiatry, Felsenstein Medical Research Center, Rabin Medical Center Beilinson Campus, Petah Tiqva, Israel
    Oncol Rep 15:107-12. 2006
    b>Phenothiazines and related antipsychotics were reported to have an antiproliferative effect in several tissue cultures...
  40. ncbi Extractive-spectrophotometric determination of some 2- and 10-disubstituted phenothiazines with dipicrylamine
    E Regulska
    Department of Chemistry, , Poland
    Acta Pol Pharm 58:151-5. 2001
    Dipicrylamine reacts in neutral medium with some 2,10-disubstituted phenothiazines (promazine, chlorpromazine and promethazine hydrochlorides, trifluoperazine dihydrochloride, thioproperazine dimethanosulphonate) forming orange or brown ..
  41. ncbi NMR-based characterization of phenothiazines as a RNA binding scaffold
    Moriz Mayer
    Department of Pharmaceutical Chemistry, University of California, San Francisco, California 94143 2280, USA
    J Am Chem Soc 126:4453-60. 2004
    b>Phenothiazines were identified by virtual screening as promising ligands for HIV-1 TAR RNA and A-site ribosomal RNA, and binding in each case was verified experimentally...
  42. pmc Fluorescent properties of DNA base analogue tC upon incorporation into DNA--negligible influence of neighbouring bases on fluorescence quantum yield
    Peter Sandin
    Physical Chemistry Section, Department of Chemistry and Bioscience, Chalmers University of Technology, SE 41296 Gothenburg, Sweden
    Nucleic Acids Res 33:5019-25. 2005
    ..This makes tC unique as a fluorescent base analogue and is thus highly interesting in a range of applications for studying e.g. structure, dynamics and kinetics in nucleic acid systems...
  43. ncbi Application of potassium dichromate and iron-thiocyanate in the spectrophotometric investigations of phenothiazines
    K Basavaiah
    Department of Studies in Chemistry, University of Mysore, India
    Farmaco 56:579-85. 2001
    A spectrophotometric procedure for the determination of phenothiazines in pure form and in a number of their pharmaceutical preparations has been developed that offers the advantages of simplicity, accuracy, precision and sensitivity over ..
  44. ncbi The metabolism of the piperazine-type phenothiazine neuroleptic perazine by the human cytochrome P-450 isoenzymes
    Jacek Wojcikowski
    Polish Academy of Sciences, Institute of Pharmacology, Smetna 12, 31 343, Cracow, Poland
    Eur Neuropsychopharmacol 14:199-208. 2004
    ..CYP2C9, CYP2E1 CYP2C19 and CYP2D6 are engaged to a lesser degree in 5-sulphoxidation, while CYP1A2, CYP3A4 and CYP2D6 in perazine N-demethylation (6-10%, depending on the isoform)...
  45. ncbi Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines
    M Viveiros
    Mycobacteriology Unit, The Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Rua Junqueira 96, 1349-008, Lisbon, Portugal
    Int J Antimicrob Agents 17:225-8. 2001
    b>Phenothiazines have been shown to inhibit the in vitro growth of multi-drug resistant (resistant to rifampicin and isoniazid) Mycobacterium tuberculosis (MDRTB)...
  46. ncbi Trypanosoma cruzi trypanothione reductase inhibitors: phenothiazines and related compounds modify experimental Chagas' disease evolution
    H W Rivarola
    Cátedra de Física Biomédica, Facultad de Ciencias Medicas, Universidad Nacional de Cordoba, Santa Rosa 1085, 5000 Cordoba, Argentina
    Curr Drug Targets Cardiovasc Haematol Disord 2:43-52. 2002
    ..This enzyme has been isolated, purified and studied by X ray crystallography. Phenothiazines and related compounds inhibit trypanothione reductase and a specially favoured fit is a phenothiazine with a 2-..
  47. ncbi Efficient oxidizing agents for determination of 2,10-disubstituted phenothiazines
    Helena Puzanowska-Tarasiewicz
    Institute of Chemistry, University of Białystok, Hurtowa 1 Bialystok 15 399, Poland
    Anal Sci 21:1149-53. 2005
    2,10-Disubstituted phenothiazines are the best drugs in psychiatry. Several methods for their analysis have been reported in the literature. The official methods are based on non-aqueous titration or spectrophotometry...
  48. ncbi Phenothiazines as anti-multi-drug resistant tubercular agents
    L Amaral
    Unit of Mycobacteriology, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Rua da Junqueira 96, 1349 008 Lisboa, Portugal
    Infect Disord Drug Targets 7:257-65. 2007
    ..provide cogent in vitro, ex vivo and in vivo evidence that supports the use of a variety of commonly available phenothiazines for the therapy of MDRTB and XDRTB, especially when the prognosis of the infection is poor and the use of the ..
  49. pmc Synergistic interaction between phenothiazines and antimicrobial agents against Burkholderia pseudomallei
    Ying Ying Chan
    Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, 8 Medical Drive, Singapore 117597, Singapore
    Antimicrob Agents Chemother 51:623-30. 2007
    ..pseudomallei. Antimicrobial agents that interacted synergistically with the phenothiazines include streptomycin, erythromycin, oleandomycin, spectinomycin, levofloxacin, azithromycin, and amoxicillin-..
  50. ncbi Cytotoxic potential of phenothiazines
    Noboru Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    Curr Drug Targets 7:1055-66. 2006
    b>Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the relatively lower cytotoxicity...
  51. ncbi Determination of lipid bilayer/water partition coefficient of new phenothiazines using the second derivative of absorption spectra method
    Andrzej Poła
    Department of Biophysics, Wrocław Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Eur J Pharm Sci 21:421-7. 2004
    ..coefficients (K(p)) between lipid bilayer of phosphatidylcholine (PC) vesicles and buffer for five new phenothiazines were determined using the second derivatives of ultraviolet absorption spectra...
  52. ncbi The relative efficacy of phenothiazines for the treatment of acute migraine: a meta-analysis
    Anne Maree Kelly
    Joseph Epstein Centre for Emergency Medicine Research at Western Health, St Albans, Vic, Australia
    Headache 49:1324-32. 2009
    Ranges of agents are used in the emergency departments to treat migraine headache. Some experts suggest that phenothiazines are among the most effective; clinical trials have been small with varied results...
  53. ncbi Differential effect of phenothiazines on MRP1 and P-glycoprotein activity
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    In Vivo 23:943-7. 2009
    ....
  54. ncbi Inhibition of drug efflux in mycobacteria with phenothiazines and other putative efflux inhibitors
    Liliana Rodrigues
    Grupo de Micobacterias, Unidade de Microbiologia Médica, Instituto de Higiene e Medicina Tropical, Universidade Nova de Lisboa, Portugal
    Recent Pat Antiinfect Drug Discov 6:118-27. 2011
    ....
  55. ncbi Chemical structure of phenothiazines and their biological activity
    Agata Jaszczyszyn
    Department of Basic Medical Sciences, Wrocław Medical University, Kochanowskiego 14, PL 51 601 Wrocław, Poland
    Pharmacol Rep 64:16-23. 2012
    b>Phenothiazines belong to the oldest, synthetic antipsychotic drugs, which do not have their precursor in the world of natural compounds...
  56. ncbi Interactions of phenothiazines with lipid bilayer and their role in multidrug resistance reversal
    K Michalak
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368, Wroclaw, Poland
    Curr Drug Targets 7:1095-105. 2006
    ..In this review we focus on phenothiazines which belong to the group of drugs known to modify MDR in different types of cells, from cancer cells up to ..
  57. ncbi Impact of oral dexamethasone versus placebo after ED treatment of migraine with phenothiazines on the rate of recurrent headache: a randomised controlled trial
    A M Kelly
    Joseph Epstein Centre for Emergency Medicine Research at Western Health and The University of Melbourne, Melbourne, Australia
    Emerg Med J 25:26-9. 2008
    ..The aim of this study was to compare the rate of recurrent headache in patients with migraine randomised to receive a single dose of oral dexamethasone or placebo at discharge after treatment in the ED with intravenous phenothiazine...
  58. ncbi Class-selective drug detection: fluorescently-labeled calmodulin as the biorecognition element for phenothiazines and tricyclic antidepressants
    Phillip M Douglass
    Department of Chemistry, University of Kentucky, Lexington, Kentucky 40506 0055, USA
    Bioconjug Chem 13:1186-92. 2002
    A small-scale, homogeneous, rapid sensing system for phenothiazines and tricyclic antidepressants (TCAs) has been developed by employing fluorescently labeled mutant calmodulin (CaM) as the recognition element...
  59. ncbi Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages
    V Hadjimitova
    Department of Medical Physics and Biophysics, Medical University, Sofia, Bulgaria
    Cell Biol Toxicol 19:3-12. 2003
    The effects of some phenothiazines (promethazine, PMZ; chlorpromazine, CPZ; levomepromazine, LVPZ; thioridazine, TRDZ; trifluoperazine, TFPZ) on the activation and viability of rat peritoneal macrophages were investigated...
  60. ncbi Kinetics and thermodynamics of peroxidase- and laccase-catalyzed oxidation of N-substituted phenothiazines and phenoxazines
    J Kulys
    Institute of Biochemistry, Vilnius, Lithuania
    J Biol Inorg Chem 5:333-40. 2000
    Steady-state and single-turnover kinetics for the oxidation of the N-substituted phenothiazines (PTs) and phenoxazines (POs) catalyzed by fungal Coprinus cinereus peroxidase and Polyporus pinsitus laccase were investigated at pH 4-10...
  61. ncbi Pharmacological characterisation of the human small conductance calcium-activated potassium channel hSK3 reveals sensitivity to tricyclic antidepressants and antipsychotic phenothiazines
    G C Terstappen
    Molecular Biology and Biochemistry Unit, GlaxoWellcome Medicines Research Centre, Via A Fleming 4, 37135 Verona, Italy
    Neuropharmacology 40:772-83. 2001
    ..Tricyclic antidepressants such as desipramine, imipramine and nortriptyline as well as phenothiazines such as fluphenazine, promethazine, chlorpromazine and trifluoperazine blocked the hSK3 channel with ..
  62. ncbi Antipsychotic medication dispensing and associated odds ratios of death in elderly veterans and war widows, 2001
    Jean Hollis
    School of Psychology, Psychology Clinic, University of Sydney, Sydney, New South Wales, Australia
    Aust N Z J Psychiatry 40:981-6. 2006
    ..To explore the odds ratios (ORs) of death associated with antipsychotic (AP) medications dispensed to elderly subjects...
  63. ncbi Excited-state properties and in vitro phototoxicity studies of three phenothiazine derivatives
    Fausto Elisei
    Department of Chemistry, University of Perugia, Italy
    Photochem Photobiol 75:11-21. 2002
    ..In particular, the photophysical properties of the compounds under investigation and the results of the study on their phototoxicity are in agreement with a mechanism that involves the radical cation of the drugs as a main intermediate...
  64. ncbi In vitro phototoxicity of phenothiazines: involvement of stable UVA photolysis products formed in aqueous medium
    G Miolo
    Department of Pharmaceutical Sciences, University of Padova, Via F Marzolo 5, I 35131 Padova, Italy
    Chem Res Toxicol 19:156-63. 2006
    ..an in vitro evaluation of the phototoxic potential of stable photoproducts formed by UVA photolysis of three phenothiazines, perphenazine, fluphenazine, and thioridazine, in a water environment...
  65. ncbi No effect of the CYP1A2*1F genotype on thioridazine, mesoridazine, sulforidazine plasma concentrations in psychiatric patients
    Pedro Dorado
    Eur J Clin Pharmacol 63:527-8. 2007
  66. ncbi [Psychopharmaceuticals and arrhythmias]
    C Binggeli
    HerzKreislaufZentrum, Kardiologie, DIM, Universitatsspital Zurich
    Ther Umsch 61:279-83. 2004
    ..Among psychotrophic drugs the low-potency phenothiazines have most often been implicated, particularly thioridazine...
  67. ncbi Phenothiazine radicals inactivate Trypanosoma cruzi dihydrolipoamide dehydrogenase: enzyme protection by radical scavengers
    José Gutiérrez-Correa
    Bioenergetics Research Centre, School of Medicine, University of Buenos Aires, Paraguay 2155, 1121 Bueno Aires, Argentina
    Free Radic Res 37:281-91. 2003
    ..The role of the observed effects of PTZ radicals for PTZ cytotoxicity is discussed...
  68. ncbi Inactivation of cholinesterase induced by chlorpromazine cation radicals
    Sanae Muraoka
    Department of Biology, Hokkaido College of Pharmacy, Katuraoka cho 7 1, Otaru 047 0264, Japan
    Pharmacol Toxicol 92:100-4. 2003
    ..These results suggest that phenothiazine cation radicals participate in toxicological signs caused by the drugs...
  69. ncbi History of the discovery and clinical introduction of chlorpromazine
    Francisco López-Muñoz
    Neuropsychopharmacology Unit, Department of Pharmacology, Faculty of Medicine, University of Alcala, Madrid, Spain
    Ann Clin Psychiatry 17:113-35. 2005
    ..The historical process of discovery and clinical introduction of chlorpromazine, one of the greatest advances of 20th century medicine and history of psychiatry, is analyzed...
  70. ncbi Investigating the post-chemiluminescence behavior of phenothiazine medications in the luminol-potassium ferricyanide system: molecular imprinting-post-chemiluminescence method for the determination of chlorpromazine hydrochloride
    Weifen Niu
    School of Chemistry and Materials Science, Shaanxi Normal University, Xi an, 710062, PR China
    Anal Bioanal Chem 385:153-60. 2006
    ..0 x 10(-7) g/ml chlorpromazine hydrochloride solution was 4.0% (n = 11). The method has been applied to the determination of chlorpromazine hydrochloride in urine and animal drinking water with satisfactory results...
  71. ncbi Self-assembling of phenothiazine compounds investigated by small-angle X-ray scattering and electron paramagnetic resonance spectroscopy
    Leandro R S Barbosa
    Instituto de Fisica da Universidade de Sao Paulo, Cx Postal 66318, CEP 05315 970 São Paulo, SP, Brazil
    J Phys Chem B 112:4261-9. 2008
    ..Besides that, at pH 6.5 the differences in motional restriction observed between 5- and 16-DSA are small, which is different from that observed for aqueous surfactant micelles...
  72. ncbi Management of opioid-induced gastrointestinal effects in patients receiving palliative care
    Christopher M Herndon
    School of Pharmacy, Texas Tech University Health Sciences Center, Lubbock, USA
    Pharmacotherapy 22:240-50. 2002
    ..Common agents administered for nausea are butyrophenones, phenothiazines, metoclopramide, and serotonin-receptor antagonists...
  73. ncbi Effect of organic modifiers on retention and enantiomeric separations by capillary electrophoresis with human serum albumin as a chiral selector in solution
    A Ahmed
    Department of Oncology, McGill University, Montreal, Canada
    J Chromatogr A 766:237-44. 1997
    ....
  74. ncbi [Drug-induced parkinsonism]
    Yasushi Shiio
    Department of Neurology, Toranomon Hospital
    Nihon Rinsho 65:377-81. 2007
  75. ncbi Primary steps of the photochemical reactions of 2-cyano-10-(3-[dimethylamino, N-oxide]-2-methylpropyl)-5-oxide-phenothiazine, the photoproduct of cyamemazine, a phototoxic neuroleptic: comparison with the sulfoxide
    Francisco Bosca
    Instituto de Tecnologia Quimica, Consejo Superior de Investigaciones Cientificas Universidad Politecnica de Valencia, 46022, Valencia, Spain
    Photochem Photobiol Sci 5:336-42. 2006
    ..6 and 2.4 x 10(6) M(-1) s(-1), respectively. In buffer, P and S triplet states react with tryptophan, indole and cysteine at rate constants of the order of 10(9) M(-1) s(-1) for Trp and indole and 10(8) M(-1) s(-1) for Cys...
  76. ncbi Partition of N-monodemethylated phenothiazine drugs to phosphatidylcholine bilayer vesicles studied by second-derivative spectrophotometry
    Shigehiko Takegami
    Kyoto Pharmaceutical University, 5 Nakauchicho, Misasagi, Yamashina ku, Kyoto 607 8414, Japan
    J Pharm Sci 91:1568-72. 2002
    The partition coefficients (Kps) of three N-monodemethylated metabolites of phenothiazines (chlorpromazine (CPZ), triflupromazine, and promazine) between phosphatidylcholine (PC) vesicles (SUV) and water were determined to evaluate their ..
  77. ncbi Contrasting action of flavonoids on phototoxic effects induced in human skin fibroblasts by UVA alone or UVA plus cyamemazine, a phototoxic neuroleptic
    Paulo Filipe
    RDDM Photobiologie, Museum national d histoire naturelle, Case Postale 26, 43 rue Cuvier, 75231, Paris Cedex 05, France
    Photochem Photobiol Sci 4:420-8. 2005
    ..Furthermore such contrasting pro-versus anti-oxidant effects have to be taken into account when using flavonoid mixtures of plant extracts...
  78. ncbi In vitro human plasma leucine(5)-enkephalin degradation is inhibited by a select number of drugs with the phenothiazine molecule in their chemical structure
    Aron D Mosnaim
    Department of Cellular and Molecular Pharmacology, Finch University of Health Sciences, Chicago Medical School, Chicago, Ill, USA
    Pharmacology 67:6-13. 2003
    ..However, neither the phenothiazines ethopropazine, methotrimeprazine, prochlorperazine and trifluoperazine nor the various commonly used ..
  79. ncbi Phenothiazine molecule provides the basic chemical structure for various classes of pharmacotherapeutic agents
    Aron D Mosnaim
    Department of Cellular and Molecular Pharmacology, Rosalind Franklin University of Medicine and Science The Chicago Medical School, N Chicago, IL 60064, USA
    Am J Ther 13:261-73. 2006
    ..Synthetic phenothiazines (with aliphatic, methylpiperazine, piperazine-ethanol, piperazine-ethyl, or piperidine side-chain) and/or ..
  80. ncbi Photosensitization of DNA strand breaks by three phenothiazine derivatives
    Giampietro Viola
    Department of Pharmaceutical Sciences, University of Padova, via Marzolo 5 Padova, Italy
    Chem Res Toxicol 16:644-51. 2003
    ..Irradiation of supercoiled plasmid DNA in the presence of these phenothiazines leads to single strand breaks...
  81. ncbi A study on the bacterial photo-toxicity of phenothiazinium based photosensitisers
    Zia Sayed
    Department of Forensic and Investigative Science, University of Central Lancashire, Preston, PR1 2HE, England, UK
    FEMS Immunol Med Microbiol 43:367-72. 2005
    ..These combined results show DNA to be a major site of action of PhBPs and suggest that this action may involve type II attack on a nucleoside(s) other than guanosine...
  82. ncbi Charge separation in acridine- and phenothiazine-modified DNA
    Kiyohiko Kawai
    The Institute of Scientific and Industrial Research SANKEN, Osaka University, Mihogaoka 8 1, Ibaraki, Osaka 567 0047, Japan
    J Phys Chem B 112:2144-9. 2008
    ....
  83. ncbi Effect of titanium dioxide on photostability of solid-state mequitazine
    Koichi Kakinoki
    Formulation and Industrial Technology Lab, Taiho Pharmaceutical Co, Ltd Tokushima 771 0194, Japan
    Chem Pharm Bull (Tokyo) 53:1092-6. 2005
    ..The photo-degradation of mequitazine with TiO(2) is a different process from mequitazine without TiO(2), because mequitazine-S-oxide and mequitazine-sulphone are not formed with normal photo-degradation of mequitazine...
  84. ncbi The oxidizing power of the glutathione thiyl radical as measured by its electrode potential at physiological pH
    Edyta Madej
    University of Oxford, Gray Cancer Institute, Mount Vernon Hospital, Northwood, Middlesex, UK
    Arch Biochem Biophys 462:94-102. 2007
    ....
  85. ncbi Phenothiazinium-based photosensitizers: antibacterials of the future?
    David A Phoenix
    Deans Office, Faculty of Science, University of Central Lancashire, Preston PR1 2HE, UK
    Trends Mol Med 9:283-5. 2003
  86. pmc Autonomous artificial nanomotor powered by sunlight
    Vincenzo Balzani
    Dipartimento di Chimica G Ciamician, Universita di Bologna, Via Selmi 2, 40126 Bologna, Italy
    Proc Natl Acad Sci U S A 103:1178-83. 2006
    ..e., fluid solution at ambient temperature); and (vii) it is stable for at least 10(3) cycles...
  87. ncbi [Psychotropic drugs used in a psychiatric hospital (pharmaco-epidemiologic aspects)]
    V N Kozyrev
    Zh Nevrol Psikhiatr Im S S Korsakova 103:25-32. 2003
    ..Normothymics may be assigned to essentially less part of the patients and 18% of them need nootropics that is consistent with routine practice...
  88. ncbi Association of psychotropic drugs, prevalence of denture-related stomatitis and oral candidosis
    V S Lucas
    Department of Prosthetic Dentistry, United Medical School, Guy's Hospital, London, United Kingdom
    Community Dent Oral Epidemiol 21:313-6. 1993
    ..9% compared with 17.6% of the controls; 4) cigarette smoking, sugar consumption and a poor standard of denture hygiene were more common in the psychiatric patients than in the controls...
  89. ncbi Maternal use of antipsychotics in early pregnancy and delivery outcome
    Margareta Reis
    Division of Clinical Pharmacology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Clin Psychopharmacol 28:279-88. 2008
    ..Because there seems to be little drug specificity, it is possible that underlying pathology or unidentified confounding explains the excess risk...
  90. ncbi Affinity of cyamemazine metabolites for serotonin, histamine and dopamine receptor subtypes
    Amine Benyamina
    INSERM U669, Hôpital Universitaire Paul Brousse, Villejuif, France
    Eur J Pharmacol 578:142-7. 2008
    ..Further investigation is required to see if the high affinities of cyamemazine sulfoxide for H(1) and 5-HT(2A) receptors are of therapeutic benefit against sleep onset insomnia and/or sleep maintenance insomnia respectively...
  91. ncbi Inhibitory effect of antipsychotic drugs on the Con A- and LPS-induced proliferative activity of mouse splenocytes: a possible mechanism of action
    A Basta-Kaim
    Laboratory of Immunoendocrinology, Department of Experimental Neuroendocrinology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland
    J Physiol Pharmacol 57:247-64. 2006
    ..Inhibition of the proliferative capability of splenocytes by chlorpromazine and clozapine resulted mainly from the activation of PI3-K/Akt pathway...
  92. ncbi Effects of phenothiazine neuroleptics on the rate of caffeine demethylation and hydroxylation in the rat liver
    W A Daniel
    Department of Pharmacokinetics and Drug Metabolism, Institute of Pharmacology, Polish Academy of Sciences,
    Pol J Pharmacol 53:615-21. 2001
    ..The CYP3A2 inhibition was most pronounced. (Ki = 20-40 microM)...
  93. ncbi Comparing adherence to and persistence with antipsychotic therapy among patients with bipolar disorder
    Mariam Hassan
    Health and Outcomes Research, AstraZeneca Pharmaceuticals LP, Wilmington, DE, USA
    Ann Pharmacother 41:1812-8. 2007
    ..Medication nonadherence is a significant problem among patients with bipolar disorder...
  94. ncbi Metabolic effects of the atypical antipsychotics
    James Wooten
    South Med J 100:771-2. 2007
  95. ncbi The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism: novel insights into drug mechanisms of action
    Helena I M Boshoff
    Tuberculosis Research Section, NIAID, National Institutes of Health, Rockville, Maryland 20852, USA
    J Biol Chem 279:40174-84. 2004
    ..were validated biochemically for two agents of previously uncategorized mechanism, pyridoacridones and phenothiazines. Analysis of this data set further revealed 150 underlying clusters of coordinately regulated genes offering ..
  96. ncbi [Prevalence and type of dermatologic disorders in psychiatric patients treated with psychotropic drugs]
    Ewa Murak-Kozanecka
    Ze Specjalistycznego Psychiatrycznego ZOZ Szpital im J Babińskiego w Łodzi
    Psychiatr Pol 38:491-505. 2004
    ....
  97. ncbi [Creutzfeldt-Jakob disease, Heidenhain variant: case report with MRI (DWI) findings]
    Walter Oleschko Arruda
    Instituto de Neurologia de Curitiba, Curitiba, PR, Brasil
    Arq Neuropsiquiatr 62:347-52. 2004
    ..She remained clinically stable and under use of chlorpromazine and mepacrine until she died due to pulmonary complications on April, 2003...
  98. ncbi Antipsychotics-induced hypersensitivity of visual perception
    Hiroyuki Uchida
    Eur Psychiatry 21:343-4. 2006
  99. ncbi Interaction between cardiac calsequestrin and drugs with known cardiotoxicity
    Il Yeong Park
    264 Fulmer, School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4660, USA
    Mol Pharmacol 67:97-104. 2005
    ....
  100. ncbi Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome
    F Rouleau
    , Centre Hospitalier Universitaire d'Angers, France
    J Cardiovasc Electrophysiol 12:61-5. 2001
    ..Flecainide did not reproduce ST segment elevation. The relationship of these abnormalities to the Brugada syndrome and the electrophysiologic hypothesis are discussed...
  101. ncbi [Acute Datura stramonium poisoning in an emergency department]
    Bernard Marc
    Urgences Médico Judiciaires, Centre Hospitalier, Compiegne
    Presse Med 36:1399-403. 2007
    ..e., atropine and scopolamine) is close to the level at which delirium occurs...

Research Grants22

  1. O-RECEPTOR PSYCHOTOMIMETICS: ACTIONS ON SINGLE NEURONS
    John Williams; Fiscal Year: 1992
    ..Compounds that have high affinity for this site such as haloperidol, phenothiazines and even SKF10047, have interactions with other receptors making it difficult to accurately assess the ..
  2. BIOCHEMISTRY OF EXCITABLE MEMBRANES
    BRUCE KRUEGER; Fiscal Year: 1991
    ..Specific binding by phenothiazines and charybdotoxin will be used to develop a strategy for channel purification...
  3. VIRUS PHOTOINACTIVATION--DIMETHYLMETHYLENE BLUE IN RBC
    Stephen Wagner; Fiscal Year: 2004
    ..abstract_text> ..
  4. Effect of Urban Form on Exercise and BMI in Black Women
    Patricia Coogan; Fiscal Year: 2009
    ..The proposed study has the potential to provide such evidence and to impact policy in the domains of both transportation/urban planning and public health. ..
  5. Mood Disorders & Diabetes: Common Disease Mechanisms
    WILLIAM REGENOLD; Fiscal Year: 2005
    ..S. Such treatments could have the potential not only to provide symptom relief but also to repair and prevent the brain disease contributing to treatment resistance. ..
  6. P-Glycoprotein and Disposition of Psychostimulants
    JOHN MARKOWITZ; Fiscal Year: 2005
    ....
  7. STRUCTURE AND GENESIS OF TAU FILAMENTS
    Jeff Kuret; Fiscal Year: 2009
    ..Together, these data will clarify the molecular events accompanying fibrillization, and feasibility of antagonizing and even reversing early stage tau filament formation in vivo. ..
  8. STRUCTURE, FUNCTION, AND REGULATION OF CASEIN KINASE-1
    Jeff Kuret; Fiscal Year: 2001
    ..In addition, a complete understanding of protein kinase structure and inhibitor selectivity will speed the rational development of protein kinase-selective inhibitors with potentially useful therapeutic properties. ..
  9. Screening Herbs for Drug Interactions
    JOHN MARKOWITZ; Fiscal Year: 2002
    ..Further, the proposed studies will complement existing and future NCCAM studies of agents such as St. John's wort and Gingko biloba. ..
  10. Materials for Sensing & Actuation
    Sylvia Daunert; Fiscal Year: 2004
    ..These biologically inspired materials will be built into novel nanofabricated structures as to synergistically enable new devices/material with unprecedented properties. ..
  11. Combined Chemoprevention Using a Nanotechnology-based Therapeutic System
    Sunil Prabhu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Clinical Development of 4-Hydroperoxyifosfamide
    LEE MORGAN; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  13. Ginkgo biloba for ECT-induced Memory Deficits
    JOHN MARKOWITZ; Fiscal Year: 2003
    ..will utilize larger groups and additional cognitive tests will be incorporated to provide more definitive conclusions regarding efficacy, optimal dose and duration, persistence of effects, and safety and tolerability ..
  14. DRUGS OF ABUSE: CHRONIC INTERACTIONS AND BEHAVIOR
    DONALD MCMILLAN; Fiscal Year: 2005
    ..abstract_text> ..
  15. CASE CONTROL STUDY OF STATIN USE AND LARGE BOWEL CANCER
    Patricia Coogan; Fiscal Year: 2004
    ..S. men and women are high, an inverse association would be of considerable public health importance. Moreover, it would shed light on a mechanism of colon carcinogenesis. ..
  16. Camptothecin Analogs for Cancer Therapy
    LEE MORGAN; Fiscal Year: 2007
    ..Prior to the latter, DEKK-TEC proposes screening the analogs in a wide spectrum of tumor models to insure the best cancer applications for the products. [unreadable] [unreadable] [unreadable]..
  17. DERIVATIVES OF DEMETHYLPENCLOMEDINE:ANTICANCER AGENTS
    LEE MORGAN; Fiscal Year: 2003
    ..abstract_text> ..