isothiocyanates

Summary

Summary: Organic compounds with the general formula R-NCS.

Top Publications

  1. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
  2. ncbi The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
  3. ncbi Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
    Dunyaporn Trachootham
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Cell 10:241-52. 2006
  4. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
  5. pmc Proteins as binding targets of isothiocyanates in cancer prevention
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:1405-13. 2011
  6. ncbi Glucosinolates and isothiocyanates in health and disease
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Trends Mol Med 18:337-47. 2012
  7. pmc TRP channel activation by reversible covalent modification
    Andrew Hinman
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 103:19564-8. 2006
  8. ncbi Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young Sam Keum
    Department of Biochemistry, College of Pharmacy, Dongguk University, 813 Siksa dong, Goyang, Kyunggi Do, 410 773, Republic of Korea
    Ann N Y Acad Sci 1229:184-9. 2011
  9. ncbi Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling
    G Kallifatidis
    Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Gut 58:949-63. 2009
  10. pmc Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    Hongting Zheng
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 60:3055-66. 2011

Detail Information

Publications276 found, 100 shown here

  1. pmc Distinct cysteine residues in Keap1 are required for Keap1-dependent ubiquitination of Nrf2 and for stabilization of Nrf2 by chemopreventive agents and oxidative stress
    Donna D Zhang
    Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65212, USA
    Mol Cell Biol 23:8137-51. 2003
    ..We propose that Keap1 is a component of a novel E3 ubiquitin ligase complex that is specifically targeted for inhibition by both chemopreventive agents and oxidative stress...
  2. ncbi The chemical diversity and distribution of glucosinolates and isothiocyanates among plants
    J W Fahey
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Phytochemistry 56:5-51. 2001
    Glucosinolates (beta-thioglucoside-N-hydroxysulfates), the precursors of isothiocyanates, are present in sixteen families of dicotyledonous angiosperms including a large number of edible species...
  3. ncbi Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
    Dunyaporn Trachootham
    Department of Molecular Pathology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    Cancer Cell 10:241-52. 2006
    ..Excessive ROS causes oxidative mitochondrial damage, inactivation of redox-sensitive molecules, and massive cell death. In vivo, PEITC exhibits therapeutic activity and prolongs animal survival...
  4. ncbi Nuclear factor E2-related factor 2-dependent antioxidant response element activation by tert-butylhydroquinone and sulforaphane occurring preferentially in astrocytes conditions neurons against oxidative insult
    Andrew D Kraft
    School of Pharmacy, University of Wisconsin, Madison, Wisconsin 53705 2222, USA
    J Neurosci 24:1101-12. 2004
    ..Strikingly, the change in neuronal gene expression after tBHQ treatment was dependent on Nrf2 activity in the astrocytes. This suggests that Nrf2-dependent genetic changes alter neuron-glia interactions resulting in neuroprotection...
  5. pmc Proteins as binding targets of isothiocyanates in cancer prevention
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:1405-13. 2011
    b>Isothiocyanates are versatile cancer-preventive compounds. Evidence from animal studies indicates that the anticarcinogenic activities of ITCs involve all the major stages of tumor growth: initiation, promotion and progression...
  6. ncbi Glucosinolates and isothiocyanates in health and disease
    Albena T Dinkova-Kostova
    Division of Cancer Research, Medical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Trends Mol Med 18:337-47. 2012
    Glucosinolates and isothiocyanates have both been objects of research for more than half a century...
  7. pmc TRP channel activation by reversible covalent modification
    Andrew Hinman
    Department of Physiology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 103:19564-8. 2006
    ..b>Isothiocyanates are membrane-permeable electrophiles that form adducts with thiols and primary amines, suggesting that ..
  8. ncbi Regulation of the Keap1/Nrf2 system by chemopreventive sulforaphane: implications of posttranslational modifications
    Young Sam Keum
    Department of Biochemistry, College of Pharmacy, Dongguk University, 813 Siksa dong, Goyang, Kyunggi Do, 410 773, Republic of Korea
    Ann N Y Acad Sci 1229:184-9. 2011
    ....
  9. ncbi Sulforaphane targets pancreatic tumour-initiating cells by NF-kappaB-induced antiapoptotic signalling
    G Kallifatidis
    Molecular OncoSurgery Group, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Gut 58:949-63. 2009
    ..The aim of the study was to identify TICs in pancreatic carcinoma for analysis of resistance mechanisms and for definition of sensitising agents...
  10. pmc Therapeutic potential of Nrf2 activators in streptozotocin-induced diabetic nephropathy
    Hongting Zheng
    Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona, USA
    Diabetes 60:3055-66. 2011
    ..To determine whether dietary compounds targeting NFE2-related factor 2 (Nrf2) activation can be used to attenuate renal damage and preserve renal function during the course of streptozotocin (STZ)-induced diabetic nephropathy...
  11. ncbi Direct and indirect antioxidant properties of inducers of cytoprotective proteins
    Albena T Dinkova-Kostova
    Division of Clinical Pharmacology, Department of Medicine, The Johns Hopkins University School ofMedicine, Baltimore, MD, USA
    Mol Nutr Food Res 52:S128-38. 2008
    ....
  12. pmc Benzyl isothiocyanate inhibits oncogenic actions of leptin in human breast cancer cells by suppressing activation of signal transducer and activator of transcription 3
    Su Hyeong Kim
    Department of Pharmacology and Chemical Biology, and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Carcinogenesis 32:359-67. 2011
    ..In conclusion, BITC could potentially be a rational therapeutic strategy for breast carcinoma in obese patients with high leptin levels...
  13. pmc Sulforaphane, a dietary component of broccoli/broccoli sprouts, inhibits breast cancer stem cells
    Yanyan Li
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Michigan, Ann Arbor, MI 48109, USA
    Clin Cancer Res 16:2580-90. 2010
    ..In this study, we evaluated sulforaphane, a natural compound derived from broccoli/broccoli sprouts, for its efficacy to inhibit breast CSCs and its potential mechanism...
  14. ncbi Molecular mechanism of rapid cellular accumulation of anticarcinogenic isothiocyanates
    Y Zhang
    Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205, USA
    Carcinogenesis 22:425-31. 2001
    b>Isothiocyanates (ITCs) are abundant in foods derived from vegetables, and many ITCs are potent cancer chemoprotective agents in animal systems...
  15. ncbi Natural isothiocyanates: genotoxic potential versus chemoprevention
    Carmela Fimognari
    Department of Pharmacology, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    Mutat Res 750:107-31. 2012
    b>Isothiocyanates, occurring in many dietary cruciferous vegetables, show interesting chemopreventive activities against several chronic-degenerative diseases, including cancer, cardiovascular diseases, neurodegeneration, diabetes...
  16. ncbi Protective effect of sulforaphane against oxidative stress: recent advances
    Carlos Enrique Guerrero-Beltrán
    Departamento de Biologia, Universidad Nacional Autonoma de Mexico, 04510 Mexico, DF, Mexico
    Exp Toxicol Pathol 64:503-8. 2012
    ..In conclusion, sulforaphane is a promising antioxidant agent that is effective to attenuate oxidative stress and tissue/cell damage in different in vivo and in vitro experimental paradigms...
  17. pmc Multi-targeted prevention of cancer by sulforaphane
    John D Clarke
    Department of Nutrition and Exercise Sciences, 117 Milam Hall, Oregon State University, Corvallis, OR 97331, USA
    Cancer Lett 269:291-304. 2008
    b>Isothiocyanates are found in cruciferous vegetables such as broccoli, Brussels sprouts, cauliflower, and cabbage...
  18. ncbi Chemoprevention by isothiocyanates and their underlying molecular signaling mechanisms
    Young Sam Keum
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen Road, Piscataway, NJ 08854, USA
    Mutat Res 555:191-202. 2004
    ..Cruciferous vegetables are rich source of glucosinolates, which are degraded into isothiocyanates by enzymatic action of plant-specific myrosinase or intestinal flora in the body...
  19. ncbi Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study
    Adeline Seow
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore
    Carcinogenesis 23:2055-61. 2002
    ..cancer risk, and this has been attributed to their high content of glucosinolate degradation products such as isothiocyanates (ITCs)...
  20. pmc Sulforaphane protects immature hippocampal neurons against death caused by exposure to hemin or to oxygen and glucose deprivation
    Lucian Soane
    Department of Anesthesiology, Center for Shock, Trauma, and Anesthesiology Research STAR, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    J Neurosci Res 88:1355-63. 2010
    ....
  21. ncbi Synergistic activity of sorafenib and sulforaphane abolishes pancreatic cancer stem cell characteristics
    Vanessa Rausch
    Molecular OncoSurgery, University of Heidelberg and German Cancer Research Center, Heidelberg, Germany
    Cancer Res 70:5004-13. 2010
    ..Our data suggest that SF may be suited to increase targeting of CSCs by SO...
  22. pmc Identification of potential protein targets of isothiocyanates by proteomics
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road, Washington, D C 20057, United States
    Chem Res Toxicol 24:1735-43. 2011
    b>Isothiocyanates (ITCs), such as phenethyl isothiocyanate (PEITC) and sulforaphane (SFN), are effective cancer chemopreventive compounds...
  23. ncbi Isothiocyanates as cancer chemopreventive agents: their biological activities and metabolism in rodents and humans
    C Clifford Conaway
    Division of Carcinogenesis and Molecular Epidemiology, American Health Foundation, Valhalla, NY 10595, USA
    Curr Drug Metab 3:233-55. 2002
    b>Isothiocyanates (ITCs) are a group of naturally occurring compounds that occur as thioglucoside conjugates, termed glucosinolates, in plants and cruciferous vegetables such as watercress, Brussels sprouts, broccoli, cabbage, kai choi, ..
  24. ncbi Transcription factor Nrf2 protects the brain from damage produced by intracerebral hemorrhage
    Xiurong Zhao
    Department of Neurology, University of Texas at Health Science Center at Houston, Houston, TX 77030, USA
    Stroke 38:3280-6. 2007
    ..This study evaluated the role of Nrf2 in protecting the brain from ICH-mediated damage...
  25. pmc Chemoprevention strategies for pancreatic cancer
    Silvia D Stan
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, 5117 Centre Avenue, 2 31 Hillman Cancer Center, Pittsburgh, PA 15213, USA
    Nat Rev Gastroenterol Hepatol 7:347-56. 2010
    ..This Review discusses the current state of the pancreatic cancer chemoprevention field and highlights the challenges ahead...
  26. pmc The molecular basis that unifies the metabolism, cellular uptake and chemopreventive activities of dietary isothiocyanates
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Carcinogenesis 33:2-9. 2012
    Organic isothiocyanates (ITCs), which are characterized by the presence of an -N=C=S group, are among the most extensively studied cancer chemopreventive agents and show highly promising chemopreventive activities...
  27. pmc Sensitization of TRPA1 by PAR2 contributes to the sensation of inflammatory pain
    Yi Dai
    Department of Anatomy and Neuroscience, Hyogo College of Medicine, Hyogo, Japan
    J Clin Invest 117:1979-87. 2007
    ....
  28. ncbi Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice
    Rong Hu
    Graduate Program in Pharmaceutical Science, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 160 Frelinghuysen, Piscataway, NJ 08854, USA
    Cancer Lett 243:170-92. 2006
    ....
  29. ncbi Inhibition of EGFR signaling in human prostate cancer PC-3 cells by combination treatment with beta-phenylethyl isothiocyanate and curcumin
    Jung Hwan Kim
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:475-82. 2006
    ....
  30. pmc Sulforaphane increases drug-mediated cytotoxicity toward cancer stem-like cells of pancreas and prostate
    Georgios Kallifatidis
    Molecular OncoSurgery, University of Heidelberg, Heidelberg, Germany
    Mol Ther 19:188-95. 2011
    ..No pronounced side effects were observed in normal cells or mice. Our data suggest that SF increases the effectiveness of various cytotoxic drugs against CSCs without inducing additional toxicity in mice...
  31. ncbi Sulforaphane-induced cell death in human prostate cancer cells is initiated by reactive oxygen species
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pennsylvania 15213, USA
    J Biol Chem 280:19911-24. 2005
    ....
  32. ncbi Sulforaphane-induced G2/M phase cell cycle arrest involves checkpoint kinase 2-mediated phosphorylation of cell division cycle 25C
    Shivendra V Singh
    Department of Pharmacology and University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, USA
    J Biol Chem 279:25813-22. 2004
    ..Activation of Chk2 in response to DNA damage is well documented, but the present study is the first published report to link Chk2 activation to cell cycle arrest by an isothiocyanate...
  33. ncbi Transcription factor Nrf2 mediates an adaptive response to sulforaphane that protects fibroblasts in vitro against the cytotoxic effects of electrophiles, peroxides and redox-cycling agents
    Larry G Higgins
    Biomedical Research Institute, Ninewells Hospital and Medical School, University of Dundee, Dundee DD1 9SY, Scotland, UK
    Toxicol Appl Pharmacol 237:267-80. 2009
    ..4- and 3.2-fold resistance against thiol-reactive electrophiles, including isothiocyanates, alpha,beta-unsaturated carbonyl compounds (e.g. acrolein), aryl halides and alkene epoxides...
  34. pmc Suppression of microtubule dynamic instability and turnover in MCF7 breast cancer cells by sulforaphane
    Olga Azarenko
    Department of Molecular, Cellular, and Developmental Biology and the Neuroscience Research Institute, University of California, Santa Barbara, CA 93106, USA
    Carcinogenesis 29:2360-8. 2008
    ..a prominent isothiocyanate present in cruciferous vegetables, is believed to be responsible along with other isothiocyanates for the cancer preventive activity of such vegetables...
  35. ncbi Sulforaphane as an inducer of glutathione prevents oxidative stress-induced cell death in a dopaminergic-like neuroblastoma cell line
    Andrea Tarozzi
    Department of Pharmacology, Alma Mater Studiorum, University of Bologna, Bologna, Italy
    J Neurochem 111:1161-71. 2009
    ..These findings show that SF may play a role in preventing Parkinson's disease...
  36. ncbi Sulforaphane protects cortical neurons against 5-S-cysteinyl-dopamine-induced toxicity through the activation of ERK1/2, Nrf-2 and the upregulation of detoxification enzymes
    David Vauzour
    School of Chemistry, Food and Pharmacy, The University of Reading, Whiteknights, Reading, UK
    Mol Nutr Food Res 54:532-42. 2010
    ..These data suggest that SFN stimulates the NF-E2-related factor-2 pathway of antioxidant gene expression in neurons and may protect against neuronal injury relevant to the aetiology of Parkinson's disease...
  37. ncbi Low concentrations of isothiocyanates protect mesenchymal stem cells from oxidative injuries, while high concentrations exacerbate DNA damage
    Fulvia Zanichelli
    Department of Experimental Medicine, Biotechnology and Molecular Biology Section, Second University of Naples, Naples, Italy
    Apoptosis 17:964-74. 2012
    b>Isothiocyanates (ITCs) are molecules naturally present in many cruciferous vegetables (broccoli, black radish, daikon radish, and cauliflowers)...
  38. ncbi beta-Phenylethyl isothiocyanate-mediated apoptosis in hepatoma HepG2 cells
    P Rose
    Department of Community, Occupational and Family Medicine, MD3, National University of Singapore, 16 Medical Drive, 117597 Singapore
    Cell Mol Life Sci 60:1489-503. 2003
    ..Taken together, these results suggest that PEITC potently induces apoptosis and cell cycle arrest in HepG2 cells and that the generation of reactive oxygen species appears to be a secondary effect...
  39. pmc Brain mitochondria from rats treated with sulforaphane are resistant to redox-regulated permeability transition
    Tiffany Greco
    Department of Anesthesiology and the Center for Shock, Trauma, and Anesthesiology Research, Baltimore, MD, USA
    J Bioenerg Biomembr 42:491-7. 2010
    ..We conclude that SFP confers resistance of brain mitochondria to redox-regulated PTP opening, which could contribute to neuroprotection observed with SFP...
  40. ncbi Epigenetic impact of dietary isothiocyanates in cancer chemoprevention
    Clarissa Gerhauser
    Division of Epigenomics and Cancer Risk Factors, German Cancer Research Center DKFZ, Heidelberg, Germany
    Curr Opin Clin Nutr Metab Care 16:405-10. 2013
    There is growing evidence that cancer chemopreventive agents including isothiocyanates (ITCs) from cruciferous vegetables target epigenetic mechanisms...
  41. ncbi Dietary isothiocyanates, glutathione S-transferase -M1, -T1 polymorphisms and lung cancer risk among Chinese women in Singapore
    B Zhao
    Department of Community, Occupational and Family Medicine, Faculty of Medicine, National University of Singapore, Singapore 117597
    Cancer Epidemiol Biomarkers Prev 10:1063-7. 2001
    Chinese populations consume a diet relatively high in isothiocyanates (ITCs), a derivative of cruciferous vegetables known to have cancer-protective effects...
  42. ncbi Sulforaphane protects against 6-hydroxydopamine-induced cytotoxicity by increasing expression of heme oxygenase-1 in a PI3K/Akt-dependent manner
    Chang Deng
    Department of Emergency, The People s Hospital of Guang Du District, Kunming 650200, PR China
    Mol Med Rep 5:847-51. 2012
    ..These results suggest that SF inhibits 6-OHDA-induced cytotoxicity through increasing HO-1 expression in a PI3K/Akt-dependent manner...
  43. ncbi Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms, and lung-cancer risk: a prospective study of men in Shanghai, China
    S J London
    USC/Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles 90033, USA
    Lancet 356:724-9. 2000
    BACKGROUND: Dietary isothiocyanates inhibit lung carcinogenesis in laboratory animals but human data are limited. Glutathione S-transferases M1 and T1 (GSTM1 and GSTT1) conjugate isothiocyanates leading to more rapid elimination...
  44. ncbi Cruciferous vegetable phytochemical sulforaphane affects phase II enzyme expression and activity in rat cardiomyocytes through modulation of Akt signaling pathway
    Emanuela Leoncini
    Dept of Biochemistry G Moruzzi, Alma Mater Studiorum Univ of Bologna, Via Irnerio 48, 40126 Bologna, Italy
    J Food Sci 76:H175-81. 2011
    ..Results of this study confirm the importance of phase II enzymes modulation as cytoprotective mechanism and support the nutritional assumption of Cruciferous vegetables as source of nutraceutical cardioprotective agents...
  45. ncbi Isothiocyanate concentrations and interconversion of sulforaphane to erucin in human subjects after consumption of commercial frozen broccoli compared to fresh broccoli
    Shikha Saha
    Institute of Food Research, Norwich Research Park, Norwich, UK
    Mol Nutr Food Res 56:1906-16. 2012
    ..We compared the bioavailability and metabolism of sulforaphane from portions of lightly cooked fresh or frozen broccoli, and investigated the bioconversion of sulforaphane to erucin...
  46. pmc Sulforaphane induces cell cycle arrest and apoptosis in acute lymphoblastic leukemia cells
    Koramit Suppipat
    Texas Children s Cancer and Hematology Centers, Texas Children s Hospital, Houston, TX, USA
    PLoS ONE 7:e51251. 2012
    ....
  47. ncbi Amelioration of Alzheimer's disease by neuroprotective effect of sulforaphane in animal model
    Hyunjin Vincent Kim
    Center for Neuro medicine, Brain Science Institute, Korea Institute of Science and Technology, Seoul, Republic of Korea
    Amyloid 20:7-12. 2013
    ..While the exact mechanism of interaction of SFN in AD has not yet been ascertained, our results suggest that SFN can aid in cognitive impairment and may protect the brain from amyloidogenic damages...
  48. pmc Downregulation of Mcl-1 through inhibition of translation contributes to benzyl isothiocyanate-induced cell cycle arrest and apoptosis in human leukemia cells
    T Zhou
    Department of Pharmacognosy, School of Pharmacy, 3rd Military Medical University, Chongqing, China
    Cell Death Dis 4:e515. 2013
    ..Taken together, these findings represent a novel mechanism by which agents targeting Mcl-1 potentiate BITC lethality in transformed and primary human leukemia cells and inhibitory activity of tumor growth of Jurkat xenograft model...
  49. ncbi Neuroprotective effect of sulforaphane in 6-hydroxydopamine-lesioned mouse model of Parkinson's disease
    Fabiana Morroni
    Department of Pharmacy and Biotechnology, Alma Mater Studiorum University of Bologna, Bologna, Italy
    Neurotoxicology 36:63-71. 2013
    ..These results suggest that SFN may potentially be effective in slowing down the progression of idiopathic PD by the modulation of oxidative stress and apoptotic machinery...
  50. ncbi Role of increased expression of the proteasome in the protective effects of sulforaphane against hydrogen peroxide-mediated cytotoxicity in murine neuroblastoma cells
    Mi Kyoung Kwak
    College of Pharmacy, Yeungnam University, 214 1 Dae Dong, Gyeongsan si, Gyeongsangbuk do 712 749, South Korea
    Free Radic Biol Med 43:809-17. 2007
    ..Therefore, inducers of proteasome expression may ameliorate the accumulation of damaged proteins associated with neurodegeneration and other diseases in whose etiologies protein oxidation plays a role...
  51. pmc Comparison of isothiocyanate metabolite levels and histone deacetylase activity in human subjects consuming broccoli sprouts or broccoli supplement
    John D Clarke
    Department of Nutrition and Exercise Sciences, Oregon State University, Corvallis, Oregon 97331, United States
    J Agric Food Chem 59:10955-63. 2011
    ..Myrosinase is required to convert dietary glucosinolates from broccoli into bioactive isothiocyanates. We evaluated isothiocyanate excretion profiles in healthy subjects who consumed broccoli sprouts or broccoli ..
  52. pmc Anti-tumor activity and signaling events triggered by the isothiocyanates, sulforaphane and phenethyl isothiocyanate, in multiple myeloma
    Jana Jakubikova
    Jerome Lipper Multiple Myeloma Center, Dept of Medical Oncology, Dana Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston MA 02115, USA
    Haematologica 96:1170-9. 2011
    b>Isothiocyanates, a family of phytochemicals found in cruciferous vegetables, have cytotoxic effects against several types of tumor cells...
  53. ncbi Safety, tolerance, and metabolism of broccoli sprout glucosinolates and isothiocyanates: a clinical phase I study
    Theresa A Shapiro
    Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Nutr Cancer 55:53-62. 2006
    ..extracts containing either glucosinolates (principally glucoraphanin, the precursor of sulforaphane) or isothiocyanates (principally sulforaphane) was conducted on healthy volunteers who were in-patients on our clinical research ..
  54. pmc Allyl isothiocyanate as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
    Mol Nutr Food Res 54:127-35. 2010
    ..Overall, AITC exhibits many desirable attributes of a cancer chemopreventive agent, and further studies are warranted in order to elucidate its mechanism of action and to assess its protective activity in humans...
  55. pmc Bioavailability of Sulforaphane from two broccoli sprout beverages: results of a short-term, cross-over clinical trial in Qidong, China
    Patricia A Egner
    Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA
    Cancer Prev Res (Phila) 4:384-95. 2011
    ..Cancer Prev Res; 4(3); 384-95. ©2011 AACR...
  56. pmc Isothiocyanates reduce mercury accumulation via an Nrf2-dependent mechanism during exposure of mice to methylmercury
    Takashi Toyama
    Doctoral Programs in Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
    Environ Health Perspect 119:1117-22. 2011
    ..Methylmercury (MeHg) exhibits neurotoxicity through accumulation in the brain. The transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2) plays an important role in reducing the cellular accumulation of MeHg...
  57. ncbi Pharmacokinetics and pharmacodynamics of isothiocyanates
    Evelyn Lamy
    University Medical Center Freiburg, Department of Environmental Health Sciences, Germany
    Drug Metab Rev 43:387-407. 2011
    b>Isothiocyanates from Brassica vegetables are of great interest for use in the cure of bacterial infections, as is their potential application in the prevention and treatment of cancer...
  58. pmc Metabolism as a key to histone deacetylase inhibition
    Praveen Rajendran
    Linus Pauling Institute, Oregon State University, Corvallis, OR, USA
    Crit Rev Biochem Mol Biol 46:181-99. 2011
    ..g. pyruvate), the yin-yang of HDAC inhibition versus HDAC activation, and the screening assays that might be most appropriate for discovery of novel HDAC inhibitors in the future...
  59. pmc Pharmacodynamics of dietary phytochemical indoles I3C and DIM: Induction of Nrf2-mediated phase II drug metabolizing and antioxidant genes and synergism with isothiocyanates
    Constance Lay Lay Saw
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Biopharm Drug Dispos 32:289-300. 2011
    ..present in cruciferous vegetables; the indoles: indole-3-carbinol (I3C), 3,3'-diindolylmethane (DIM); and the isothiocyanates (ITCs): phenethyl isothiocyanate (PEITC) and sulforaphane (SFN)...
  60. pmc Sulforaphane prevents microcystin-LR-induced oxidative damage and apoptosis in BALB/c mice
    Xiaoyun Sun
    State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, CAS, People s Republic of China
    Toxicol Appl Pharmacol 255:9-17. 2011
    ..This raises the possibility of a similar protective effect in human populations, particularly in developing countries where freshwaters are polluted by blooming algae...
  61. ncbi Sulforaphane as a promising molecule for fighting cancer
    Carmela Fimognari
    Department of Pharmacology, University of Bologna, Bologna, Italy
    Mutat Res 635:90-104. 2007
    ..Several studies have documented the cancer-preventive activity of a significant number of isothiocyanates (ITCs), the majority of which occur in plants, especially in Cruciferous vegetables...
  62. ncbi Differential expression and stability of endogenous nuclear factor E2-related factor 2 (Nrf2) by natural chemopreventive compounds in HepG2 human hepatoma cells
    Woo Sik Jeong
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA
    J Biochem Mol Biol 38:167-76. 2005
    ....
  63. ncbi Sulforaphane attenuates hepatic fibrosis via NF-E2-related factor 2-mediated inhibition of transforming growth factor-β/Smad signaling
    Chang Joo Oh
    Department of Internal Medicine, Research Institute of Aging and Metabolism, WCU Program, Kyungpook National University School of Medicine, Daegu 700 721, Republic of Korea
    Free Radic Biol Med 52:671-82. 2012
    ..Collectively, these results show that SFN elicits an antifibrotic effect on hepatic fibrosis through Nrf2-mediated inhibition of the TGF-β/Smad signaling and subsequent suppression of HSC activation and fibrogenic gene expression...
  64. pmc Sulforaphane inhibits extracellular, intracellular, and antibiotic-resistant strains of Helicobacter pylori and prevents benzo[a]pyrene-induced stomach tumors
    Jed W Fahey
    Lewis B and Dorothy Cullman Cancer Chemoprotection Center, Department of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine, 725 North Wolfe Street, Baltimore, MD 21205 2185, USA
    Proc Natl Acad Sci U S A 99:7610-5. 2002
    ....
  65. ncbi Selected isothiocyanates rapidly induce growth inhibition of cancer cells
    Yuesheng Zhang
    Arizona Cancer Center and Department of Medicine, College of Medicine, University of Arizona, Tucson, AZ, USA
    Mol Cancer Ther 2:1045-52. 2003
    Many plant-derived isothiocyanates (ITCs), which occur in human diet, are potent cancer chemopreventive agents in animals. Among the anticarcinogenic mechanisms that have been revealed for ITCs is the inhibition of cell proliferation...
  66. pmc Isothiocyanates inhibit proteasome activity and proliferation of multiple myeloma cells
    Lixin Mi
    Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC 20057, USA
    Carcinogenesis 32:216-23. 2011
    b>Isothiocyanates (ITCs), including benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC) and sulforaphane, compounds found in cruciferous vegetable, are highly effective in inducing cell cycle arrest and apoptosis in a variety of ..
  67. pmc Notch activation by phenethyl isothiocyanate attenuates its inhibitory effect on prostate cancer cell migration
    Su Hyeong Kim
    Department of Pharmacology and Chemical Biology, and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
    PLoS ONE 6:e26615. 2011
    ..Because Notch signaling is implicated in epithelial-mesenchymal transition and metastasis, the present study suggests that anti-metastatic effect of PEITC may be augmented by a combination regimen involving a Notch inhibitor...
  68. ncbi Prostate cancer chemopreventive activity of phenethyl isothiocyanate through epigenetic regulation (review)
    Long G Wang
    NYU Cancer Institute, New York University School of Medicine, Manhattan VAMC, New York, NY 10010, USA
    Int J Oncol 37:533-9. 2010
    ..The isothiocyanates, including phenethyl isothiocyanate (PEITC), from cruciferous vegetables have been demonstrated as active ..
  69. ncbi Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage
    Petra Bergström
    Department of Clinical Chemistry and Transfusion Medicine, Sahlgrenska University Hospital, Institute of Biomedicine, University of Gothenburg, Bruna Straket 16, SE 413 45 Gothenburg, Sweden
    Neuropharmacology 60:343-53. 2011
    ..The findings also demonstrate that part of this response can be built up by repeated transient stimulation, possibly explaining how intermittent intake of sulforaphane can result in long-term protection from radical-induced disease...
  70. ncbi Protective effect of sulforaphane pretreatment against cisplatin-induced liver and mitochondrial oxidant damage in rats
    Leobardo Gaona-Gaona
    Departamento de Biologia, Facultad de Química UNAM, UNAM, Mexico, D F, Mexico
    Toxicology 286:20-7. 2011
    ..The hepatoprotective effect of SFN was associated to the preservation of mitochondrial function, antioxidant enzymes and prevention of liver and mitochondrial oxidant stress...
  71. pmc Food as a source for quorum sensing inhibitors: iberin from horseradish revealed as a quorum sensing inhibitor of Pseudomonas aeruginosa
    Tim Holm Jakobsen
    Department of International Health, Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark
    Appl Environ Microbiol 78:2410-21. 2012
    ..Real-time PCR (RT-PCR) and DNA microarray studies showed that iberin specifically blocks expression of QS-regulated genes in P. aeruginosa...
  72. pmc The role of Nrf2 signaling in the regulation of antioxidants and detoxifying enzymes after traumatic brain injury in rats and mice
    Yuan Hong
    Department of Neurosurgery, 2nd Affiliated Hospital, Zhejiang University, Hangzhou, China
    Acta Pharmacol Sin 31:1421-30. 2010
    ..To determine whether Nrf2 signaling pathway activation could attenuate oxidative stress and neuronal damage following traumatic brain injury (TBI)...
  73. pmc Effective killing of Gleevec-resistant CML cells with T315I mutation by a natural compound PEITC through redox-mediated mechanism
    H Zhang
    Department of Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 22:1191-9. 2008
    ..Our results suggest that PEITC is a promising compound capable of killing Gleevec-resistant CML cells through a ROS-mediated mechanism and warrants further investigations...
  74. ncbi Pharmacological targeting of the transcription factor Nrf2 at the basal ganglia provides disease modifying therapy for experimental parkinsonism
    Agnieszka Jazwa
    Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Madrid, Spain
    Antioxid Redox Signal 14:2347-60. 2011
    ..These results provide strong pharmacokinetic and biochemical evidence for activation of Nrf2 and phase II genes in the brain and also offer a neuroprotective strategy that may have clinical relevance for PD therapy...
  75. pmc Molecular targets of dietary phenethyl isothiocyanate and sulforaphane for cancer chemoprevention
    Ka Lung Cheung
    Graduate Program in Pharmaceutical Science, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA
    AAPS J 12:87-97. 2010
    ..Phenethyl isothiocyanate (PEITC) and sulforaphane (SFN) are two of the most widely investigated isothiocyanates from the crucifers...
  76. pmc Pancreatic tumor suppression by benzyl isothiocyanate is associated with inhibition of PI3K/AKT/FOXO pathway
    Srinivas Reddy Boreddy
    Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, USA
    Clin Cancer Res 17:1784-95. 2011
    ..In this study we hypothesized the involvement of PI3K/AKT/FOXO pathway in BITC-induced apoptosis...
  77. ncbi Modulation of phase II enzymes by sulforaphane: implications for its cardioprotective potential
    Cristina Angeloni
    Department of Biochemistry G Moruzzi, University of Bologna, Bologna, Italy
    J Agric Food Chem 57:5615-22. 2009
    ....
  78. pmc The role of STAT-3 in the induction of apoptosis in pancreatic cancer cells by benzyl isothiocyanate
    Ravi P Sahu
    Department of Pharmaceutical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, TX 79106, USA
    J Natl Cancer Inst 101:176-93. 2009
    ..Benzyl isothiocyanate (BITC), a compound found in cruciferous vegetables, has been reported to have anticancer properties, but the mechanism whereby it inhibits growth of human pancreatic cancer cells is incompletely understood...
  79. ncbi Benzyl isothiocyanate-induced apoptosis in human breast cancer cells is initiated by reactive oxygen species and regulated by Bax and Bak
    Dong Xiao
    2 32A Hillman Cancer Center Research Pavilion, 5117 Centre Avenue, Pittsburgh, PA 15213, USA
    Mol Cancer Ther 5:2931-45. 2006
    ..In conclusion, the present study reveals a complex signaling leading to growth arrest and apoptosis induction by BITC...
  80. ncbi Proteasome-mediated degradation of cell division cycle 25C and cyclin-dependent kinase 1 in phenethyl isothiocyanate-induced G2-M-phase cell cycle arrest in PC-3 human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Mol Cancer Ther 3:567-75. 2004
    ..Furthermore, the results of the present study point toward involvement of both caspase-8- and caspase-9-mediated pathways in apoptosis induction by PEITC...
  81. pmc Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines
    Syed M Meeran
    Department of Biology, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
    PLoS ONE 5:e11457. 2010
    ..The mechanisms by which SFN imparts its chemopreventive properties are of considerable interest and little is known of its preventive potential for breast cancer...
  82. pmc Species-specific pharmacology of Trichloro(sulfanyl)ethyl benzamides as transient receptor potential ankyrin 1 (TRPA1) antagonists
    Lana Klionsky
    Department of Neuroscience, Amgen, Inc, Thousand Oaks, California, USA
    Mol Pain 3:39. 2007
    ..In summary, we conclude that both human and rat TRPA1 channels show similar AITC and noxious cold activation profiles, but TCEB compounds display species-specific differential pharmacology at TRPA1...
  83. pmc Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells
    Dong Xiao
    Department of Pharmacology and Chemical Biology and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 285:26558-69. 2010
    ..In conclusion, the present study provides novel insight into the molecular circuitry of PEITC-induced cell death involving ROS production due to inhibition of complex III and OXPHOS...
  84. ncbi Sulforaphane protects brains against hypoxic-ischemic injury through induction of Nrf2-dependent phase 2 enzyme
    Zhang Ping
    Department of Clinical Laboratory, Changzhou No 2 People s Hospital, Jiangsu 213003, PR China
    Brain Res 1343:178-85. 2010
    ..These results demonstrated that SFN could exert neuroprotective effects through increasing Nrf2 and HO-1 expression...
  85. pmc Activation of NF-E2-related factor-2 reverses biochemical dysfunction of endothelial cells induced by hyperglycemia linked to vascular disease
    Mingzhan Xue
    Clinical Sciences Research Institute, Warwick Medical School, University of Warwick, University Hospital, Coventry, UK
    Diabetes 57:2809-17. 2008
    ..The aim of this study was to assess whether activation of nrf2 by sulforaphane in human microvascular endothelial cells prevents metabolic dysfunction in hyperglycemia...
  86. pmc Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells
    Ajay Bommareddy
    Department of Pharmacology and Chemical Biology, and University of Pittsburgh Cancer Institute, Pennsylvania, USA
    Cancer Res 69:3704-12. 2009
    ..In conclusion, the present study indicates that Atg5 plays an important role in regulation of PEITC-induced autophagic and apoptotic cell death...
  87. ncbi Combined inhibitory effects of curcumin and phenethyl isothiocyanate on the growth of human PC-3 prostate xenografts in immunodeficient mice
    Tin Oo Khor
    Center for Cancer Prevention Research, Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers The State University of New Jersey, 160 Freilinghuysen Road, Piscataway, NJ 08854, USA
    Cancer Res 66:613-21. 2006
    ..Furthermore, we found that combination of PEITC and curcumin could be effective in the cancer-therapeutic treatment of prostate cancers...
  88. ncbi Breast cancer risk in premenopausal women is inversely associated with consumption of broccoli, a source of isothiocyanates, but is not modified by GST genotype
    Christine B Ambrosone
    Division of Cancer Prevention and Population Science, Roswell Park Cancer Institute, Buffalo, NY, USA
    J Nutr 134:1134-8. 2004
    ..Cruciferous vegetables contain precursors of isothiocyanates (ITCs), which may be chemopreventive through potent inhibition of phase I, and induction of phase II enzymes, ..
  89. ncbi Chemoprevention by isothiocyanates: molecular basis of apoptosis induction
    Yoshimasa Nakamura
    Department of Biofunctional Chemistry, Okayama University, Okayama, Japan
    Forum Nutr 61:170-81. 2009
    ..promising group of compounds that have a cancer-chemopreventive property are organosulfur compounds, such as isothiocyanates (ITCs)...
  90. ncbi The principal urinary metabolites of dietary isothiocyanates, N-acetylcysteine conjugates, elicit the same anti-proliferative response as their parent compounds in human bladder cancer cells
    Li Tang
    Department of Chemoprevention, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Anticancer Drugs 17:297-305. 2006
    b>Isothiocyanates (ITCs) are a class of well-known cancerpreventive phytochemicals, but are primarily disposed of and concentrated in the urine as N-acetylcysteine conjugates (NAC-ITCs) in vivo...
  91. pmc Metabolism and tissue distribution of sulforaphane in Nrf2 knockout and wild-type mice
    John D Clarke
    Molecular and Cellular Biology Program, Oregon State University, Corvallis, Oregon 97331, USA
    Pharm Res 28:3171-9. 2011
    ..To determine the metabolism and tissue distribution of the dietary chemoprotective agent sulforaphane following oral administration to wild-type and Nrf2 knockout (Nrf2(-/-)) mice...
  92. ncbi Cancer chemoprevention of intestinal polyposis in ApcMin/+ mice by sulforaphane, a natural product derived from cruciferous vegetable
    Rong Hu
    Department of Pharmaceutics, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA
    Carcinogenesis 27:2038-46. 2006
    ....
  93. pmc Candidate dietary phytochemicals modulate expression of phase II enzymes GSTP1 and NQO1 in human lung cells
    Xiang Lin Tan
    Division of Pulmonary Medicine, Albert Einstein College of Medicine, Bronx, NY, USA
    J Nutr 140:1404-10. 2010
    ..We conclude that modulation of lung cell phase II metabolism by chemopreventive agents requires cell- and agent-specific discovery and testing...
  94. ncbi Discovery and development of sulforaphane as a cancer chemopreventive phytochemical
    Yuesheng Zhang
    Department of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Acta Pharmacol Sin 28:1343-54. 2007
    ....
  95. ncbi Growth-inhibiting activities of phenethyl isothiocyanate and its derivatives against intestinal bacteria
    M G Kim
    Dept of Bioenvironmental Chemistry, College of Agriculture and Life Sciences, Chonbuk Natl Univ, Chonju 561 756, South Korea
    J Food Sci 74:M467-71. 2009
    ..Addition of various functional groups to isothiocyanates resulted in selective inhibitory activity against harmful bacteria with low concentrations of aromatic ..
  96. ncbi Mitochondrial peroxiredoxin 3 is rapidly oxidized in cells treated with isothiocyanates
    Kristin K Brown
    Free Radical Research Group, Department of Pathology, University of Otago, Christchurch, New Zealand
    Free Radic Biol Med 45:494-502. 2008
    b>Isothiocyanates are phytochemicals with anti-cancer properties that include the ability to trigger apoptosis...
  97. pmc Benzyl isothiocyanate suppresses pancreatic tumor angiogenesis and invasion by inhibiting HIF-α/VEGF/Rho-GTPases: pivotal role of STAT-3
    Srinivas Reddy Boreddy
    Department of Biomedical Sciences and Cancer Biology Center, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas, United States of America
    PLoS ONE 6:e25799. 2011
    ..Taken together, our results suggest that BITC suppresses pancreatic tumor growth by inhibiting tumor angiogenesis through STAT-3-dependant pathway...
  98. pmc Prevention of mammary carcinogenesis in MMTV-neu mice by cruciferous vegetable constituent benzyl isothiocyanate
    Renaud Warin
    Department of Pharmacology, and University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Cancer Res 69:9473-80. 2009
    ..The present study demonstrating efficacy of BITC against mammary cancer in an animal model provides impetus to determine its activity in a clinical setting...
  99. pmc Novel class of glutathione transferases from cyanobacteria exhibit high catalytic activities towards naturally occurring isothiocyanates
    Eric Wiktelius
    Department of Biochemistry and Organic Chemistry, Biomedical Centre, Uppsala University, Box 576, SE 751 23 Uppsala, Sweden
    Biochem J 406:115-23. 2007
    ..Synechococcus elongatus PCC 6301 were found to catalyse the conjugation of naturally occurring plant-derived isothiocyanates to glutathione at high rates...
  100. pmc p53-Independent apoptosis by benzyl isothiocyanate in human breast cancer cells is mediated by suppression of XIAP expression
    Su Hyeong Kim
    Department of Pharmacology and Chemical Biology, University of Pittsburgh Cancer Institute, University of Pittsburgh School of Medicine, Pennsylvania, USA
    Cancer Prev Res (Phila) 3:718-26. 2010
    ..In conclusion, the present study provides novel insight into the molecular circuitry of BITC-induced apoptosis to indicate suppression of XIAP expression as a critical mediator of this process...
  101. pmc p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging
    Lars R Perk
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:250-9. 2010
    ..To enable widespread use of (89)Zr-immuno-PET, we now introduce the novel BFC p-isothiocyanatobenzyl-desferrioxamine B (Df-Bz-NCS) and compare its performance in (89)Zr-immuno-PET with the reference BFC TFP-N-sucDf...

Research Grants64

  1. Molecular Mechanisms of Chemoprevention: NRF2 Signaling
    Thomas W Kensler; Fiscal Year: 2013
    ..g., dithiolethiones, isothiocyanates, triterpenoids)...
  2. Randomized trial of PEITC as a modifier of NNK metabolism in smokers
    Jian Min Yuan; Fiscal Year: 2012
    ..Observational epidemiological studies have demonstrated that dietary intake of cruciferous vegetables or isothiocyanates is associated with a reduced risk of lung cancer...
  3. Biomarkers of NNK in prediction of lung cancer development in smokers
    Jian Min Yuan; Fiscal Year: 2013
    ..e., the sum of nicotine, cotinine, trans-32-hydroxycotinine and their corresponding glucuronides), and total isothiocyanates in urine, and beta-cryptoxanthin and other dietary antioxidants in serum on all study subjects...
  4. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2009
    ..e., broccoli-family) vegetables is associated with lower risk of several cancers. Isothiocyanates (ITC), the bioactive components derived from glucosinolates in cruciferous vegetables, have been shown to ..
  5. Antioxidants and Antiinflammatory in Colorectal Cancer
    Ah Ng Tony Kong; Fiscal Year: 2012
    ..This is an R01 competing continuation application to study the mechanism of action of antioxidants [the isothiocyanates, sulforaphane (SFN) and phenethyl isothiocyanate (PEITC)] and the anti-inflammatory [the beta diketones, ..
  6. Homogenous HTS Assays to Screen for Inhibitors of Keap1-Nrf2 Interaction
    Longqin Hu; Fiscal Year: 2010
    ..These inhibitors will mimic the actions of electrophiles like isothiocyanates and Michael acceptors in the induction of cytoprotective enzymes but will potentially be more selective and ..
  7. Comparative Mechanisms of Cancer Chemoprevention
    Roderick H Dashwood; Fiscal Year: 2013
    ..Core, this competing continuation addresses the application (and possible risks) of dietary indoles and isothiocyanates for cancer intervention, through comparative mechanism, biomarker, and preclinical models (lymphoma, prostate,..
  8. ISC-4 as a Novel Lung Cancer Chemopreventive Agent
    Arun K Sharma; Fiscal Year: 2010
    ..Recently, our extensive structure-activity study involving naturally occurring and synthetic isothiocyanates and corresponding newly developed selenium analogs, the isoselenocyanates, have identified phenylbutyl ..
  9. Mechanisms of Chemoprevention by Isothiocyanates
    Fung Lung Chung; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Induction of apoptosis is believed to be an important mechanism by which isothiocyanates (ITCs) inhibit carcinogenesis...
  10. Nutrigenetics of cruciferous vegetable intake and breast cancer prognosis
    Li Tang; Fiscal Year: 2013
    ..The rationale includes: (1) Cruciferous vegetables are rich sources of isothiocyanates (ITCs), a group of promising anti-cancer agents;(2) Polymorphic genes of key enzymes in the pathway of ITC ..
  11. Function of a molecular target of cancer chemoprevention
    Dennis J Templeton; Fiscal Year: 2010
    ..However, beginning nearly 50 years ago, it was shown that certain chemicals, among them compounds such as isothiocyanates (ITCs), prevent carcinogen-induced cancers in animals...
  12. Akt3 Signaling as a Therapeutic Target
    Gavin P Robertson; Fiscal Year: 2012
    ..key therapeutic targets in melanoma and development of novel synthetic compounds derived from chemopreventive isothiocyanates to inhibit Akt3 signaling...
  13. LIPID PEROXIDATION IN COLORECTAL CANCER
    Manuela Gago Dominguez; Fiscal Year: 2009
    ..including marine n-3 fatty acids, non-steroidal anti-inflammatory drugs (NSAIDs), physical exercise, dietary isothiocyanates (ITC), vitamin D and calcium, and folate. 1.2...
  14. An anti-inflammatory role for bioactive nutrient isothiocyanates
    Janet V Cross; Fiscal Year: 2010
    ..One class of chemopreventive compounds, the bioactive nutrient isothiocyanates (ITCs), are abundant in cruciferous vegetables such as broccoli, and have a chemical structure that suggest ..
  15. Diet and Risk of Ovarian Cancer
    Ellen Chang; Fiscal Year: 2005
    ..Our specific aims are to evaluate the relationship between ovarian cancer risk and (a) phytoestrogens and isothiocyanates, (b) eggs, dietary fats and dairy products, (c) alcohol, and (d) dietary patterns...
  16. Vitamin D, alcohol, and risk of lymphomas in a prospective cohort of women
    ELLEN TING YEE CHANG; Fiscal Year: 2010
    ..to vitamin D from diet or sunlight;indices of dietary antioxidant intake;consumption of phytoestrogens or isothiocyanates;or consumption of alcohol at various ages is associated with reduced risk of lymphoid malignancies among 110,..
  17. Dietary Isothiocyanates in Cancer Prevention: Effects of Estrogen Metabolism
    Marilyn Morris; Fiscal Year: 2007
    unreadable] DESCRIPTION (provided by applicant): There is a crucial need for breast cancer prevention. Isothiocyanates (ITCs) are dietary constituents present predominantly in cruciferous vegetables present in the diet, and ..
  18. Breast Cancer Gene-Diet Interaction US Polish Migrants
    Dorothy Pathak; Fiscal Year: 2003
    ..metabolites of cruciferous vegetables, including indole-3-carbinol (I3C), indolo[3,2-b]carbazole (ICZ) and isothiocyanates, can, in certain situations, inhibit the carcinogenic effects of ES in in vitro assays and the development of ..
  19. BREAST CANCER GENE-DIET INTERACTIONS IN POLISH WOMEN
    Dorothy Pathak; Fiscal Year: 2003
    ..metabolites of cruciferous vegetables, including indole-3-carbinol (I3C), indolo[3,2-b]carbazole (ICZ) and isothiocyanates, can, in certain situations, inhibit the carcinogenic effects of ES in in vitro assays and the development of ..
  20. Metal Catalyzed CN and CS Bond Forming Reactions for Bioconjugation Targets
    ALEXANDER MICHAEL SPOKOYNY; Fiscal Year: 2013
    ..proposed catalytic functionalizations will include important functional motifs, such as azides, thiols, and isothiocyanates. Successful establishment of the reactive intermediates and optimized conditions for the catalytic reaction ..
  21. TOTAL SYNTHESIS OF ANTIFUNGAL AGENTS
    ANTHONY BARRETT; Fiscal Year: 1991
    ..dimethylbutanoyl chloride and aryl titanium chelates (6) the construction of alpha,beta-epoxy isonitriles via the corresponding isocyanates or isothiocyanates and deoxygenation or desulfurization or via chromium carbene chemistry.
  22. Plant Foods and Endometrial Cancer Epidemiology
    PAMELA HORN ROSS; Fiscal Year: 2005
    ..specific aims are to evaluate the relationship between endometrial cancer risk and (a) cruciferous vegetables isothiocyanates, (b) various measures of dietary antioxidants, (c) whole grains / dietary fiber, (d) refined grains / ..
  23. Effects of Brassica on Markers of Colon Cancer Risk
    JAY FOWKE; Fiscal Year: 2002
    There is considerable basic science research to suggest that isothiocyanates (ITC) or several indole analogs (e.g., indole-3carbinol (I3C)) slow cellular proliferation, re-instate apoptotic action, and reduce colon tumor incidence...
  24. Isothiocyanates, Limonene and Breast Cancer Prevention
    Cynthia Thomson; Fiscal Year: 2006
    ..The research proposed here will test the hypothesis that dietary intake of isothiocyanates and d-limonene is associated with reduced risk of breast cancer recurrence in the WHEL cohort...
  25. NOVEL STRATEGIES FOR CHEMOPROTECTION AGAINST CANCER
    Paul Talalay; Fiscal Year: 2000
    ..Most of the inducer activity in these plants appears to associated with isothiocyanates and their glucosinolate precursors...
  26. GENES, DIET AND CARCINOGEN ACTIVATION IN SMOKERS
    Loic Le Marchand; Fiscal Year: 2004
    ..for CYPIAI, AhR and CYPIBI; and 3) intake and urinary levels of phytochemicals (specific flavonoids, total isothiocyanates) and plasma levels of micronutrients with these markers of activation...
  27. Isothiocyanates as specific antagonists of human SXR
    David Eaton; Fiscal Year: 2009
    ..Finally, they could help to further elucidate the risks and benefits of sulforaphane, a potential dietary phytochemical that has been proposed as a safe 'nutraceutical'compound to reduce cancer risk. ..
  28. ISOTHIOCYANATE EXCRETION, BRASSICA, AND BREAST CANCER
    JAY FOWKE; Fiscal Year: 2002
    ..Vegetables of the Brassica genus, such as broccoli and cabbage, contain isothiocyanates (ITC) which increase glutathione-S-transferase (GST) activity, leading to the excretion of potentially ..
  29. Nutrition and Thyroid Cancer Risk in the CTS Cohort
    PAMELA HORN ROSS; Fiscal Year: 2007
    ..1) to evaluate the relationship between papillary thyroid cancer risk and (a) cruciferous vegetables and isothiocyanates, using a newly developed database, and (b) overall and abdominal adiposity; and (2) to evaluate the ..
  30. ISOTHIOCYANATE CONJUGATES AS CANCER CHEMOPREVENTIVES
    Guo qiang Zheng; Fiscal Year: 1992
    The objective of this project is to develop a series of water soluble conjugates of isothiocyanates as a novel type of prodrug with site specificity and less toxicity against bladder and colon cancer...
  31. DIETARY FACTORS IN THE ETIOLOGY OF CANCER IN SHANGHAI
    Jian Min Yuan; Fiscal Year: 2006
    ..selenium, retinol, carotenoids, tea polyphenols) in cancers of the lung and liver; the role of dietary isothiocyanates in cancers of the stomach, esophagus, and colorectum; and the role of tea polyphenols in cancers of the ..
  32. CHEMOPREVENTION OF LUNG AND ESOPHAGEAL CANCER
    Stephen Hecht; Fiscal Year: 2002
    ..Under the support of the cooperative agreement that preceded this program project, we have established isothiocyanates are outstanding inhibitors of lung and esophageal cancer in animal models...
  33. The Mechanism of Lung Chemoprevention Mediated by ITCs
    Yang Ming Yang; Fiscal Year: 2005
    b>Isothiocyanates (ITCs) and their conjugates are effective inhibitors against lung tumorigenesis in animal models...
  34. Isothiocyanates in the Chemoprevention of Bladder Cancer
    Yuesheng Zhang; Fiscal Year: 2007
    This Project focuses on determining the cancer-preventive activity of isothiocyanates (ITCs) in the bladder...
  35. CARCINOGENIC CYCLIC NITROSAMINE DNA ADDUCTS
    Stephen S Hecht; Fiscal Year: 2010
    ..The proposed research is significant because of the known human exposure to these carcinogens through the diet, tobacco products, and endogenous formation. ..
  36. Chemoprevention in Mice after Tobacco Smoke Exposure
    Hanspeter Witschi; Fiscal Year: 2004
    ..Eventually, these preclinical studies in an animal model of "former smokers" will help to evaluate the potential usefulness and also possible dosage regimens of chemopreventive agents characterized by their suppressing action. ..
  37. NOVEL GST AND DETOXICATION OF DIOL EPOXIDES
    Shivendra Singh; Fiscal Year: 2006
    ..In the long-term, this knowledge will guide us in developing strategies for prevention of PAH-induced cancers in humans. ..
  38. MECHANISM OF ANTICARCINOGENIC ACTIVITY--ORGANOSULFIDES
    Shivendra Singh; Fiscal Year: 2003
    ..Insights gained from these studies should help in devising practical dietary recommendation for humans. ..
  39. METABOLISM OF CARCINOGENIC TOBACCO SPECIFIC NITROSAMINES
    Stephen Hecht; Fiscal Year: 2003
    ..abstract_text> ..
  40. Tobacco Carcinogenesis
    Stephen Hecht; Fiscal Year: 2005
    ..Steven Tannenbaum (MIT), Dr. Jack Henningfield (Johns Hopkins and Pinney Associates), Drs. Jeffrey Seeman and Anthony Tricker (Philip Morris), and Dr. John Lauterbach (an independent consultant, formerly with Brown and Williamson). ..
  41. ROLE OF HUMAN GST PI POLYMORPHISM IN DRUG RESISTANCE
    Shivendra Singh; Fiscal Year: 2003
    ..These studies, in the long term, may be valuable in identifying subjects that may be at a higher risk for developing GST-mediated resistance to some alkylating agents. ..
  42. Lung Cancer Chemoprevention: Isothiocyanates, inositol
    Stephen Hecht; Fiscal Year: 2008
    ..Together with our colleagues, we have developed naturally occurring isothiocyanates, their N-acetylcysteine conjugates, and myo-inositol (MI) as chemopreventive agents against lung cancer...
  43. Bioactive Food Comoponents, Alternative Medicine and Cancer Chemoprevention: Rece
    Shivendra Singh; Fiscal Year: 2007
    ..The theme of our symposium is highly focused and attracts leaders and highly accomplished scientists to discuss promises and challenges in cancer chemoprevention research. [unreadable] [unreadable] [unreadable] [unreadable]..
  44. Toxicological Relevance of Human GST P1-1 Polymorphism
    Shivendra Singh; Fiscal Year: 2005
    ..abstract_text> ..
  45. Hormone Status Postmenopause: Colonic Bacterial Effects
    Johanna Lampe; Fiscal Year: 2003
    ..The results of this study will provide novel data regarding the relationship of the equol-producer phenotype, a marker of colonic nticrofloral environment, to lifetime estrogen exposure. ..
  46. Serum IGFs--Effects of a Soy Intervention in Humans
    Johanna Lampe; Fiscal Year: 2002
    ..It provides an ideal design to evaluate the effects of isoflavones on the IGF system and to explore relationships between IGFs and colonic epithelial cell proliferation in humans. ..
  47. HOST GENES AND COLONIC BACTERIA--PROBING FOR INHERITANCE
    Johanna Lampe; Fiscal Year: 2002
    ..If we can establish that the equol-producer phenotype is an inherited trait, we can then work to identify the associated genotype and determine more effectively whether this is a biomarker of breast cancer risk. ..
  48. Chemopreventive Efficacy of Broccoli Sprouts in Humans
    Thomas Kensler; Fiscal Year: 2004
    ..most notably 3-day-old broccoli sprouts, contain potent phase 2 enzyme inducer activity in the form of isothiocyanates or their glucosinolate precursors...
  49. Glucuronidation in Humans--Genotypes and Phenotypes
    Johanna Lampe; Fiscal Year: 2004
    ..The randomized cross-over design will allow us to test efficiently for diet effects within individuals, as well as for gene-by-diet and sex-by-diet interactions. ..
  50. Chemoprevention of Esophageal Squamous Cell Carcinoma
    Gary Stoner; Fiscal Year: 2004
    ..abstract_text> ..
  51. Human Gut Microflora Profiling for Population Studies
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..
  52. International Lung Cancer Consortium: Pooled analysis o*
    Paul Brennan; Fiscal Year: 2006
    ..abstract_text> ..
  53. Gene-Nutrient Interactions and Breast Cancer
    SUSAN STECK; Fiscal Year: 2007
    ..abstract_text> ..
  54. Pilot for a Multicenter Case-Control Study of Pancreatic Cancer in a High Risk r*
    Paul Brennan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  55. Breast and Bone Density: Impact of Colonic Environment
    Johanna Lampe; Fiscal Year: 2006
    ..If equol-producer phenotype can predict differences in cumulative estrogen exposure / metabolism, it may serve as an early marker of breast cancer risk. ..
  56. UGT Polymorphisms and Hormonally-Mediated Biomarkers in Premenopausal Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  57. Breast Cancer, Benign Breast Disease, and Isoflavone Metabolism in Chinese Women
    Johanna Lampe; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable] [unreadable]..
  58. DNA Damage: Fruit & Vegetable Effects in a Feeding Trial
    Johanna Lampe; Fiscal Year: 2005
    ..The existing intervention provides an ideal design in which to evaluate the relationships between biotransformation enzyme systems and DNA damage in humans. ..
  59. Role of the Amygdala in Opioid Self-administration in Rats with Chronic Pain.
    Thomas Martin; Fiscal Year: 2009
    ....
  60. Multicentric Pooled Analysis of Second Primary Cancer
    Paul Brennan; Fiscal Year: 2004
    ..g., ultraviolet light); (ii) an investigation of rare cancer types (e.g., bone cancer or sarcomas); and (iii) an investigation of second primary cancers which may be increased due to treatment of a first primary cancer (e.g., leukemia). ..
  61. GLUTATHIONE TRANSFERASES IN HUMANS: DIETARY INFLUENCES
    Johanna Lampe; Fiscal Year: 2006
    ..abstract_text> ..