sulfur compounds

Summary

Summary: Inorganic or organic compounds that contain sulfur as an integral part of the molecule.

Top Publications

  1. ncbi Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulphide
    Albert Tangerman
    Department of Periodontology, Academic Centre Oral Health, University Medical Centre, Groningen, The Netherlands
    J Clin Periodontol 34:748-55. 2007
  2. ncbi Comparison of volatile sulfur compound concentrations measured with a sulfide detector vs. gas chromatography
    J Furne
    The Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    J Dent Res 81:140-3. 2002
  3. pmc Transformation of sulfur compounds by an abundant lineage of marine bacteria in the alpha-subclass of the class Proteobacteria
    J M Gonzalez
    Department of Marine Sciences, University of Georgia, Athens, Georgia 30602, USA
    Appl Environ Microbiol 65:3810-9. 1999
  4. ncbi Sulfur and sulfur compounds in plant defence
    Ifeanyi D Nwachukwu
    Department of Plant Physiology Bio III, RWTH, Aachen University, 52056 Aachen, Germany
    Nat Prod Commun 7:395-400. 2012
  5. ncbi Expression and functional roles of Bradyrhizobium japonicum genes involved in the utilization of inorganic and organic sulfur compounds in free-living and symbiotic conditions
    Masayuki Sugawara
    Department of Soil Water and Climate, University of Minnesota, St Paul, USA
    Mol Plant Microbe Interact 24:451-7. 2011
  6. ncbi Stability of odorants from pig production in sampling bags for olfactometry
    Michael J Hansen
    Department of Biosystems Engineering, Aarhus University, Tjele, Denmark
    J Environ Qual 40:1096-102. 2011
  7. ncbi The effects of garlic-derived sulfur compounds on cell proliferation, caspase 3 activity, thiol levels and anaerobic sulfur metabolism in human hepatoblastoma HepG2 cells
    Małgorzata Iciek
    Medical College of Jagiellonian University, Krakow, Poland
    Cell Biochem Funct 30:198-204. 2012
  8. ncbi Production of methanethiol and volatile sulfur compounds by the archaeon "Ferroplasma acidarmanus"
    David J Baumler
    Cellular and Molecular Biology, University of Wisconsin, Madison, WI, 53706, USA
    Extremophiles 11:841-51. 2007
  9. pmc The averaging effect of odorant mixing as determined by air dilution sensory tests: a case study on reduced sulfur compounds
    Ki Hyun Kim
    Atmospheric Environment Laboratory, Department of Environment and Energy, Sejong University, Seoul 143 747, Korea
    Sensors (Basel) 11:1405-17. 2011
  10. ncbi Effect of reduced sulfur compounds on the fermentation of phosphoric acid pretreated sugarcane bagasse by ethanologenic Escherichia coli
    I U Nieves
    Department of Microbiology and Cell Science, University of Florida, Box 110700, Gainesville, FL 32611, USA
    Bioresour Technol 102:5145-52. 2011

Research Grants

Detail Information

Publications242 found, 100 shown here

  1. ncbi Intra- and extra-oral halitosis: finding of a new form of extra-oral blood-borne halitosis caused by dimethyl sulphide
    Albert Tangerman
    Department of Periodontology, Academic Centre Oral Health, University Medical Centre, Groningen, The Netherlands
    J Clin Periodontol 34:748-55. 2007
    ..The aim of this study was to unravel the origen and cause of intra-oral and extra-oral halitosis...
  2. ncbi Comparison of volatile sulfur compound concentrations measured with a sulfide detector vs. gas chromatography
    J Furne
    The Minneapolis Veterans Affairs Medical Center, MN 55417, USA
    J Dent Res 81:140-3. 2002
    The accuracy of the Halimeter, an inexpensive, simple instrument that measures total breath volatile sulfur compounds (VSCs), has not been adequately tested...
  3. pmc Transformation of sulfur compounds by an abundant lineage of marine bacteria in the alpha-subclass of the class Proteobacteria
    J M Gonzalez
    Department of Marine Sciences, University of Georgia, Athens, Georgia 30602, USA
    Appl Environ Microbiol 65:3810-9. 1999
    ..seawater and sediments were characterized with respect to their ability to transform organic and inorganic sulfur compounds. Fifteen strains representing the Roseobacter group (a phylogenetic cluster of marine bacteria in the alpha-..
  4. ncbi Sulfur and sulfur compounds in plant defence
    Ifeanyi D Nwachukwu
    Department of Plant Physiology Bio III, RWTH, Aachen University, 52056 Aachen, Germany
    Nat Prod Commun 7:395-400. 2012
    ..As studies continue in this area, it is becoming increasingly evident that sulfur and sulfur compounds play far more important roles in plant defence than perhaps previously suspected.
  5. ncbi Expression and functional roles of Bradyrhizobium japonicum genes involved in the utilization of inorganic and organic sulfur compounds in free-living and symbiotic conditions
    Masayuki Sugawara
    Department of Soil Water and Climate, University of Minnesota, St Paul, USA
    Mol Plant Microbe Interact 24:451-7. 2011
    ..These results indicate that strains of Bradyrhizobium spp. likely use organosulfur compounds for growth and survival in soils, as well as for legume nodulation and nitrogen fixation...
  6. ncbi Stability of odorants from pig production in sampling bags for olfactometry
    Michael J Hansen
    Department of Biosystems Engineering, Aarhus University, Tjele, Denmark
    J Environ Qual 40:1096-102. 2011
    ..experiment, the bags were filled with a humid gas mixture containing carboxylic acids, phenols, indoles, and sulfur compounds and analyzed with proton-transfer-reaction mass spectrometry after 0, 4, 8, 12, and 24 h...
  7. ncbi The effects of garlic-derived sulfur compounds on cell proliferation, caspase 3 activity, thiol levels and anaerobic sulfur metabolism in human hepatoblastoma HepG2 cells
    Małgorzata Iciek
    Medical College of Jagiellonian University, Krakow, Poland
    Cell Biochem Funct 30:198-204. 2012
    The aim of the present studies was to determine whether the mechanism of biological action of garlic-derived sulfur compounds in human hepatoma (HepG2) cells can be dependent on the presence of labile sulfane sulfur in their molecules...
  8. ncbi Production of methanethiol and volatile sulfur compounds by the archaeon "Ferroplasma acidarmanus"
    David J Baumler
    Cellular and Molecular Biology, University of Wisconsin, Madison, WI, 53706, USA
    Extremophiles 11:841-51. 2007
    ..acidarmanus" produces methanethiol through the metabolism of methionine, cysteine, or sulfate. This is the first report of a methanethiol-producing acidophile, thus identifying a new contributor to the global sulfur cycle...
  9. pmc The averaging effect of odorant mixing as determined by air dilution sensory tests: a case study on reduced sulfur compounds
    Ki Hyun Kim
    Atmospheric Environment Laboratory, Department of Environment and Energy, Sejong University, Seoul 143 747, Korea
    Sensors (Basel) 11:1405-17. 2011
    ..of mixing different odorants, a series of air dilution sensory (ADS) tests were conducted using four reduced sulfur compounds [RSC: hydrogen sulfide (H(2)S), methanethiol (CH(3)SH), dimethylsulfide (DMS), and dimethyldisulfide (DMDS)] ..
  10. ncbi Effect of reduced sulfur compounds on the fermentation of phosphoric acid pretreated sugarcane bagasse by ethanologenic Escherichia coli
    I U Nieves
    Department of Microbiology and Cell Science, University of Florida, Box 110700, Gainesville, FL 32611, USA
    Bioresour Technol 102:5145-52. 2011
    The addition of reduced sulfur compounds (thiosulfate, cysteine, sodium hydrosulfite, and sodium metabisulfite) increased growth and fermentation of dilute acid hydrolysate of sugarcane bagasse by ethanologenic Escherichia coli (strains ..
  11. ncbi Formation of volatile sulfur compounds and metabolism of methionine and other sulfur compounds in fermented food
    Sophie Landaud
    AgroParisTech INRA, INRA Centre de Biotechnologies Agro Industrielles, 78850, Thiverval Grignon, France
    Appl Microbiol Biotechnol 77:1191-205. 2008
    The formation of volatile sulfur compounds (VSC) in fermented food is a subject of interest...
  12. pmc The genome sequence of the obligately chemolithoautotrophic, facultatively anaerobic bacterium Thiobacillus denitrificans
    Harry R Beller
    Lawrence Livermore National Laboratory, P O Box 808, L 542, Livermore, California 94551 0808, USA
    J Bacteriol 188:1473-88. 2006
    ..e., those involving sulfur, nitrogen, and carbon) and groundwater restoration...
  13. ncbi Effects of oil drops containing Lactobacillus salivarius WB21 on periodontal health and oral microbiota producing volatile sulfur compounds
    Nao Suzuki
    Section of General Dentistry, Department of General Dentistry, Fukuoka Dental College, Tamura, Sawara ku, Fukuoka, Japan
    J Breath Res 6:017106. 2012
    ..drops containing Lactobacillus salivarius WB21 on periodontal health and oral microbiota producing volatile sulfur compounds (VSCs). For this study, 42 subjects were randomly assigned to receive oil samples containing L...
  14. ncbi The levels of volatile sulfur compounds in mouth air from patients with chronic periodontitis
    C C Tsai
    Graduate Institute of Dental Sciences, College of Dental Medicine and Chung Ho Memorial Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan
    J Periodontal Res 43:186-93. 2008
    Volatile sulfur compounds may be the main source of oral malodor...
  15. pmc Involvement of a branched-chain aminotransferase in production of volatile sulfur compounds in Yarrowia lipolytica
    Daniela Cernat Bondar
    INRA, Unité Mixte de Recherches Génie et Microbiologie des Procédés Alimentaires, CBAI, 78850 Thiverval Grignon, France
    Appl Environ Microbiol 71:4585-91. 2005
    The enzymatic degradation of L-methionine and the subsequent formation of volatile sulfur compounds (VSCs) are essential for the development of the typical flavor in cheese...
  16. ncbi A study of sorptive loss patterns for reduced sulfur compounds in the use of the bag sampling method
    Ki Hyun Kim
    Atmospheric Environment Laboratory, Department of Earth and Environmental Sciences, Sejong University, Seoul, Korea
    Environ Monit Assess 123:259-69. 2006
    ..bag sampling method were examined and characterized in terms of recovery rate with respect to four reduced sulfur compounds (RSC) including H2S, CH3SH, DMS, and DMDS...
  17. pmc Effects of reduced sulfur compounds on Pd-catalytic hydrodechlorination of trichloroethylene in groundwater by cathodic H2 under electrochemically induced oxidizing conditions
    Songhu Yuan
    State Key Lab of Biogeology and Environmental Geology, China University of Geosciences, 388 Lumo Road, Wuhan, Hubei, 430074, P R China
    Environ Sci Technol 47:10502-9. 2013
    Reduced sulfur compounds (RSCs) poison Pd catalysts for catalytic hydrodechlorination of contaminants in anoxic groundwater...
  18. ncbi Stoichiometric modeling of oxidation of reduced inorganic sulfur compounds (Riscs) in Acidithiobacillus thiooxidans
    Roberto A Bobadilla Fazzini
    Biosigma S A, Loteo Los Libertadores, Lote 106, Colina, Chile
    Biotechnol Bioeng 110:2242-51. 2013
    The prokaryotic oxidation of reduced inorganic sulfur compounds (RISCs) is a topic of utmost importance from a biogeochemical and industrial perspective...
  19. ncbi Prediction of periodontopathic bacteria in dental plaque of periodontal healthy subjects by measurement of volatile sulfur compounds in mouth air
    Mitsuo Kishi
    Department of Developmental Oral Health Science, Division of Oral Health, Iwate Medical University School of Dentistry, Morioka, Japan
    Arch Oral Biol 58:324-30. 2013
    The aim of this study was to determine whether measurements of volatile sulfur compounds (VSCs) are useful to predict colonization of periodontopathic bacteria...
  20. ncbi Modulation of histone acetylation by garlic sulfur compounds
    Nathalie Druesne-Pecollo
    UMR U INSERM, Universite Paris, Bobigny, France
    Anticancer Agents Med Chem 11:254-9. 2011
    ..The aim of this review is to describe available data on sulfur compounds from garlic and histone acetylation and to discuss their potential for cancer prevention...
  21. ncbi Sulfur metabolism in phototrophic sulfur bacteria
    Niels Ulrik Frigaard
    Copenhagen Biocenter, Department of Biology, University of Copenhagen, Ole Maaløes Vej 5, 2200 Copenhagen N, Denmark
    Adv Microb Physiol 54:103-200. 2009
    Phototrophic sulfur bacteria are characterized by oxidizing various inorganic sulfur compounds for use as electron donors in carbon dioxide fixation during anoxygenic photosynthetic growth...
  22. ncbi A review of methods for the determination of reduced sulfur compounds (RSCs) in air
    Sudhir Kumar Pandey
    Atmospheric Environment Laboratory, Department of Earth and Environmental Sciences, Sejong University, Seoul 143 747, Korea
    Environ Sci Technol 43:3020-9. 2009
    The importance of reduced sulfur compounds (RSCs) in air is well-known for its significant effect on global atmospheric chemistry and malodor and quality of life...
  23. ncbi Observation of sorptive losses of volatile sulfur compounds during natural gas sampling
    Michael Sulyok
    Institute of Analytical Chemistry, Vienna University of Technology, Austria
    J Chromatogr A 946:301-5. 2002
    The reason for the compound-dependent over-estimation of the recoveries of several volatile organic sulfur compounds when using a Silcosteel cylinder for sample storage as reported earlier was examined...
  24. ncbi Effect of chewing gums on the production of volatile sulfur compounds (VSC) in vivo
    Cassiano K Rösing
    Lutheran University of Brazil, Brazil
    Acta Odontol Latinoam 22:11-4. 2009
    ..It can be concluded that VSC production is diminished after chewing gum and that the use of chewing gums reduces temporarily the VSC production enhanced by cysteine rinses...
  25. ncbi Precursors and formation of pyrithione and other pyridyl-containing sulfur compounds in drumstick onion, Allium stipitatum
    Roman Kubec
    Department of Applied Chemistry, University of South Bohemia, České Budějovice, Czech Republic
    J Agric Food Chem 59:5763-70. 2011
    ..This represents the first report of pyrithione formation as a natural product...
  26. ncbi Parallel microwave-assisted synthesis of ionic liquids and screening for denitrogenation of straight-run diesel feed by liquid-liquid extraction
    Miguel A Ceron
    Programa de Ingenieria Moleculár Instituto Mexicano del Petroleoó Eje Central Lazaro Cardenas, D F Mexico
    Comb Chem High Throughput Screen 15:427-32. 2012
    ....
  27. ncbi Sulfur-centered reactive intermediates derived from the oxidation of sulfur compounds of biological interest
    Z Abedinzadeh
    Laboratoire de Chimie Physique, UMR 8601 CNRS, Universite Rene Descartes, Paris, France
    Can J Physiol Pharmacol 79:166-70. 2001
    ..This paper discusses the present state of research on the formation and reactivity of certain sulfur-centered radicals [RS*, RSS*, RS*+, (RSSR)*+] and their implications for biological systems...
  28. ncbi Permanganate oxidation of sulfur compounds to prevent poisoning of Pd catalysts in water treatment processes
    Dalia Angeles-Wedler
    UFZ Helmholtz Centre for Environmental Research, Department of Environmental Technology, Permoserstrasse 15, 04318 Leipzig, Germany
    Environ Sci Technol 42:5734-9. 2008
    ..The practical application of Pd-catalyzed water treatment processes is impeded by catalyst poisoning by reduced sulfur compounds (RSCs)...
  29. pmc An exported rhodanese-like protein is induced during growth of Acidithiobacillus ferrooxidans in metal sulfides and different sulfur compounds
    Pablo Ramirez
    Laboratory of Molecular Microbiology and Biotechnology and Millennium Institute for Advanced Studies in Cell Biology and Biotechnology, Department of Biology, Faculty of Sciences, University of Chile, Santiago
    Appl Environ Microbiol 68:1837-45. 2002
    ..ferrooxidans...
  30. ncbi Chemical properties and mechanisms determining the anti-cancer action of garlic-derived organic sulfur compounds
    Claudia Cerella
    Laboratoire de Biologie Moléculaire et Cellulaire de Cancer, Hopital Kirchberg, Luxemburg, Germany
    Anticancer Agents Med Chem 11:267-71. 2011
    Organic sulfur compounds (OSCs) derived from plants, fungi or bacteria can serve as chemopreventive and/or chemotherapeutic agents and have been attracting medical and research interest as a promising source for novel anti-cancer agents...
  31. ncbi Modulation of volatile sulfur compounds by wine yeast
    J H Swiegers
    The Australian Wine Research Institute, PO Box 197, Glen Osmond, SA 5064 Adelaide, Australia
    Appl Microbiol Biotechnol 74:954-60. 2007
    b>Sulfur compounds in wine can be a 'double-edged sword'...
  32. ncbi Microbial cycling of volatile organic sulfur compounds
    B P Lomans
    Department of Microbiology, Faculty of Science, University of Nijmegen, The Netherlands
    Cell Mol Life Sci 59:575-88. 2002
    Microbial cycling of volatile organic sulfur compounds (VOSCs), especially dimethyl sulfide (DMS) and methanethiol (MT), is intensively studied because these compounds play an important role in the processes of global warming, acid ..
  33. ncbi Specificity of respiratory pathways involved in the reduction of sulfur compounds by Salmonella enterica
    Andrew P Hinsley
    Centre for Metalloprotein Spectroscopy and Biology, School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, UK
    Microbiology 148:3631-8. 2002
    ..Mechanisms are proposed by which the bacterium is able to utilize an insoluble sulfur substrate by means of reactions at the cytoplasmic rather than the outer membrane...
  34. ncbi Mechanisms by which garlic and allyl sulfur compounds suppress carcinogen bioactivation. Garlic and carcinogenesis
    J A Milner
    Nutrition Department, The Pennsylvania State University, University Park, 16802, USA
    Adv Exp Med Biol 492:69-81. 2001
    ..Future research should focus on how genetic variability and daily environmental factors influence the anticancer benefits attributed to garlic and its allyl sulfur components...
  35. ncbi Evaluation of oral and nasal halitosis parameters in patients with repaired cleft lip and/or palate
    Flávio Monteiro-Amado
    Hospital for Rehabilitation of Craniofacial Anomalies, Universidade of São Paulo, and Master of Science in Stomatology by Bauru Dental School, Universidade of São Paulo, Bauru, Brazil
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 100:682-7. 2005
    ..The objective of this study was to investigate the relationship between halitosis parameters in patients with and without cleft lip and/or palate...
  36. ncbi Detection of odorous compounds in breath
    S Van den Velde
    Department of Periodontology, Catholic University of Leuven, Leuven, Belgium
    J Dent Res 88:285-9. 2009
    ..We concluded that hydrogen sulfide, methyl mercaptan and, to a much lesser extent, dimethyl sulfide, di- and trisulfide can contribute to oral malodor. The role of other compounds, such as amines and organic acids, seems insignificant...
  37. ncbi Effect of nitrogen supplementation and Saccharomyces species on hydrogen sulfide and other volatile sulfur compounds in shiraz fermentation and wine
    Maurizio Ugliano
    The Australian Wine Research Institute, Glen Osmond, South Australia, Australia
    J Agric Food Chem 57:4948-55. 2009
    ..Hydrogen sulfide (H(2)S) was monitored throughout fermentation, and a total of 16 volatile sulfur compounds (VSCs) were quantified in the finished wines. For the S...
  38. ncbi Identification and biosynthesis of tropone derivatives and sulfur volatiles produced by bacteria of the marine Roseobacter clade
    Verena Thiel
    Institut fur Organische Chemie, Technische Universitat Braunschweig, Hagenring 30, 38106 Braunschweig, Germany
    Org Biomol Chem 8:234-46. 2010
    ..The unstable tropone hydrate 42 was identified as an intermediate of the tropone biosynthesis that was also released together with tropolone (38)...
  39. ncbi Development of a compact and simple gas chromatography for oral malodor measurement
    Takatoshi Murata
    Department of Oral Health, Nippon Dental University, Tokyo, Japan
    J Periodontol 77:1142-7. 2006
    Volatile sulfur compounds (VSCs) in oral air are the only type of gases correlated with the strength of oral malodor...
  40. ncbi [Oxidation of inorganic sulfur compounds by obligatory organotrophic bacteria]
    D Iu Sorokin
    Institute of Microbiology, Russian Academy of Sciences, pr 60 let Oktyabrya 7 2, Moscow, 117312 Russia
    Mikrobiologiia 72:725-39. 2003
    ..Among culturable marine and (halo)alkaliphilic heterotrophs oxidizing sulfur compounds (thiosulfate and, much less actively, elemental sulfur and sulfide) incompletely to tetrathionate, ..
  41. ncbi Effects of selected organo-sulfur compounds on melanin formation
    Heuy Ling Chu
    Department of Food Science and Technology, Chia Nan University of Pharmacy and Science, 60 Erh Jen Road, Section 1, Pao An, Jen Te Hsing, Tainan, Taiwan, Republic of China
    J Agric Food Chem 57:7072-7. 2009
    The effect of organo-sulfur compounds, including 1-propylmercaptan (PM), dimethyl disulfide (DMDS), diallyl disulfide (DADS), propyl disulfide (PDS), and 2,5-dimethylthiophene (DMT), on melanin formation was investigated...
  42. ncbi Influence of anxiety on the production of oral volatile sulfur compounds
    Caroline Morini Calil
    Department of Physiological Sciences, Piracicaba Dental School, State University of Campinas, Piracicaba, SP, Brazil
    Life Sci 79:660-4. 2006
    ..The aim of this study was to evaluate the influence of anxiety on the production of volatile sulfur compounds (VSC)...
  43. pmc Differential protein expression during growth of Acidithiobacillus ferrooxidans on ferrous iron, sulfur compounds, or metal sulfides
    Pablo Ramirez
    Laboratorio de Microbiología Molecular y Biotecnología, Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Santiago, Chile
    Appl Environ Microbiol 70:4491-8. 2004
    ..The first consisted of proteins highly upregulated by growth on sulfur compounds (and downregulated by growth on ferrous iron): a 44-kDa outer membrane protein, an exported 21-kDa putative ..
  44. ncbi On the transformation of sulfur-containing amino acids and peptides to volatile sulfur compounds (VSC) in the human mouth
    S M Waler
    Dental Faculty, University of Oslo, Norway
    Eur J Oral Sci 105:534-7. 1997
    Halitosis is most often caused by oral conditions. Volatile sulfur compounds (VSC), constituting the major components of oral malodor, are produced by anaerobic, gram-negative bacteria retained mainly in periodontal pockets or on the ..
  45. ncbi Comparison of the use of the Halimeter and the Oral Chroma™ in the assessment of the ability of common cultivable oral anaerobic bacteria to produce malodorous volatile sulfur compounds from cysteine and methionine
    Nathanael O Salako
    Department of Developmental and Preventive Sciences, Faculty of Dentistry, Health Sciences Centre, Kuwait University, Jabriya, Kuwait
    Med Princ Pract 20:75-9. 2011
    To compare the use of the Halimeter and the Oral Chroma™ to assess the ability of common oral anaerobic bacteria isolated from the Kuwaiti population to produce volatile sulfur compounds (VSCs).
  46. ncbi Effect of green tea on volatile sulfur compounds in mouth air
    Parth Lodhia
    Department of Oral Biological and Medical Sciences, Faculty of Dentistry, University of British Columbia, Vancouver, Canada
    J Nutr Sci Vitaminol (Tokyo) 54:89-94. 2008
    ..Many food products are claimed to be effective in controlling halitosis. Halitosis is caused mainly by volatile sulfur compounds (VSCs) such as H(2)S and CH(3)SH produced in the oral cavity...
  47. ncbi Formation of aroma compounds and lipoxygenase (EC 1.13.11.12) activity in unblanched leek (Allium ampeloprasum Var. Bulga) slices during long-term frozen storage
    Ghita Studsgaard Nielsen
    Department of Dairy and Food Science, Centre of Advanced Food Studies, The Royal Veterinary and Agricultural University, Rolighedsvej 30, 1958 Frederiksberg C, Denmark
    J Agric Food Chem 51:1970-6. 2003
    ..The aroma profile changed from consisting of almost only sulfur compounds such as dipropyl disulfide [concentration in fresh leek (FL) = 0...
  48. pmc Novel pathway for catabolism of the organic sulfur compound 3,3'-dithiodipropionic acid via 3-mercaptopropionic acid and 3-Sulfinopropionic acid to propionyl-coenzyme A by the aerobic bacterium Tetrathiobacter mimigardefordensis strain DPN7
    Jan Hendrik Wübbeler
    Institut fur Molekulare Mikrobiologie und Biotechnologie, Westfalische Wilhelms Universitat Munster, 48149 Munster, Germany
    Appl Environ Microbiol 74:4028-35. 2008
    ..Therefore, a new pathway is proposed for the catabolism of DTDP via 3MP, 3SP, and 3SP-CoA toward propionyl-CoA, which is then further catabolized via the 2-methylcitric acid cycle in T. mimigardefordensis...
  49. ncbi On the performance and inertness of different materials used for the enrichment of sulfur compounds from air and gaseous samples
    E Baltussen
    Eindhoven University of Technology, Laboratory of Instrumental Analysis, The Netherlands
    J Chromatogr A 864:345-50. 1999
    ..PDMS) is compared to that of the adsorbents Carbotrap and Tenax for the enrichment of volatile and reactive sulfur compounds. These included: 1- and 2-propanethiol, tetrahydrothiophene, 2-thioethanol and 2-ethylthioethanol...
  50. ncbi Applications of direct analysis in real time mass spectrometry (DART-MS) in Allium chemistry. 2-propenesulfenic and 2-propenesulfinic acids, diallyl trisulfane S-oxide, and other reactive sulfur compounds from crushed garlic and other Alliums
    Eric Block
    Department of Chemistry, University at Albany, SUNY, Albany, New York 12222, USA
    J Agric Food Chem 58:4617-25. 2010
    ..Disulfanes and polysulfanes are detected only when the Allium samples are heated, consistent with earlier conclusions that these are not primary products from cut or crushed alliums...
  51. ncbi Protective effects of garlic sulfur compounds against DNA damage induced by direct- and indirect-acting genotoxic agents in HepG2 cells
    C Belloir
    Institut National de la Recherche Agronomique, Unité Mixte de Recherche de Toxicologie Alimentaire, BP 86510, 17 rue Sully, 21065 Dijon Cedex, France
    Food Chem Toxicol 44:827-34. 2006
    ..This study demonstrated that garlic OSC displayed antigenotoxic activity in human metabolically competent cells...
  52. ncbi Biodesulfurization of refractory organic sulfur compounds in fossil fuels
    Mehran Soleimani
    Department of Chemical and Biochemical Engineering, The University of Western Ontario London, Ontario, Canada N6A 5B9
    Biotechnol Adv 25:570-96. 2007
    ..sulfur removal at higher temperature, and isolating new strains for desulfurizing a broader range of sulfur compounds. This article comprehensively reviews and discusses key issues, advances and challenges for a competitive ..
  53. ncbi Investigation of the storage stability of selected volatile sulfur compounds in different sampling containers
    M Sulyok
    Institute of Analytical Chemistry, Vienna University of Technology, Austria
    J Chromatogr A 917:367-74. 2001
    ..The Silcosteel sample cylinders were suitable for sampling of volatile sulfur compounds with respect to the stability of the analytes, but the recoveries exceeded 100% especially for the higher ..
  54. pmc Regulation of a novel Acidithiobacillus caldus gene cluster involved in metabolism of reduced inorganic sulfur compounds
    Olena I Rzhepishevska
    Molecular Biology, Umea University, SE 901 87 Umea, Sweden
    Appl Environ Microbiol 73:7367-72. 2007
    Acidithiobacillus caldus has been proposed to play a role in the oxidation of reduced inorganic sulfur compounds (RISCs) produced in industrial biomining of sulfidic minerals...
  55. ncbi Quantification of volatile sulfur compounds in complex gaseous matrices by solid-phase microextraction
    Annika T Nielsen
    Department of Water and Environmental Studies, Linkoping University, Sweden
    J Chromatogr A 963:57-64. 2002
    Procedures were assessed for quantifying nine volatile sulfur compounds found in complex gaseous samples collected at a biogas-production plant and a sewage treatment plant...
  56. ncbi Inhibition of orally produced volatile sulfur compounds by zinc, chlorhexidine or cetylpyridinium chloride--effect of concentration
    Alix Young
    Department of Cariology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Eur J Oral Sci 111:400-4. 2003
    ..ions, chlorhexidine (CHX) and cetylpyridinium chloride (CPC) are all known to inhibit production of volatile sulfur compounds (VSCs). The objective was to examine the anti-VSC dose-response effects of each of the above agents...
  57. ncbi Some insights into the gas chromatographic determination of reduced sulfur compounds (RSCs) in air
    Ki Hyun Kim
    Department of Earth and Environmental Sciences, Sejong University, Seoul, Korea
    Environ Sci Technol 39:6765-9. 2005
    The analytical properties of four reduced sulfur compounds (RSCs), including hydrogen sulfide (H2S), methyl mercaptan (CH3SH), dimethyl sulfide (DMS), and dimethyl disulfide (DMDS), were investigated to improve the techniques for their ..
  58. ncbi Effect of triclosan dentifrices on mouth volatile sulphur compounds and dental plaque trypsin-like activity during experimental gingivitis development
    G R Nogueira-Filho
    Department of Periodontics, Faculty of Dentistry, Bahia Science Foundation, Salvador, Bahia, Brazil
    J Clin Periodontol 29:1059-64. 2002
    ....
  59. ncbi The effect of cysteine on production of volatile sulphur compounds by cheese-ripening bacteria
    M López del Castillo-Lozano
    UMR 782, AgroParisTech, Laboratoire de Génie et Microbiologie des Procédés Alimentaires, Centre de Biotechnologies Agro Industrielles, 78850 Thiverval Grignon, France
    Int J Food Microbiol 122:321-7. 2008
    ..An initial sensory approach showed that such an effect could have a strong impact on the global odour of ripened cheeses...
  60. ncbi Effect of different mouth rinses on third molar surgery-related oral malodor
    Hidayet Burak Polat
    Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Cumhuriyet University, Sivas, Turkey
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 105:e1-8. 2008
    ..The purpose of this study was to assess the effects of 4 types of widely used commercial mouth rinses on third molar surgery-related oral malodor...
  61. ncbi Relationship between total salivary protein content and volatile sulfur compounds levels in malodor patients
    Praweena Sopapornamorn
    Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Oral Surg Oral Med Oral Pathol Oral Radiol Endod 103:655-60. 2007
    ..The purpose of this study was to evaluate the relationship between total salivary protein and VSC levels...
  62. ncbi Contribution of periodontal pathogens on tongue dorsa analyzed with real-time PCR to oral malodor
    Muneo Tanaka
    Department of Preventive Dentistry, Graduate School of Dentistry, Osaka University, 1 8 Yamadaoka, Suita, Osaka 565 0871, Japan
    Microbes Infect 6:1078-83. 2004
    ..These results suggest that these five periodontal pathogens on tongue dorsa may contribute greatly to VSC production...
  63. ncbi The assessment of methyl mercaptan, an important clinical marker for the diagnosis of oral malodor
    S Awano
    Department of Preventive Dentistry, Kyushu Dental College, Kitakyushu, Japan
    J Dent 32:555-9. 2004
    ..This study aimed to determine the clinical assessment of volatile sulfur compound (VSCs) for the evaluation of noticeable oral malodor using gas chromatography (GC)...
  64. ncbi Relationship between volatile sulphide compounds concentration and oral bacteria species detection in the elderly
    Hidenobu Senpuku
    Laboratory Head, Department of Bacteriology, National Institute of Infectious Diseases, 1 23 1, Toyama, Shinjuku ku, Tokyo 162 8640, Japan
    Int Dent J 54:149-53. 2004
    ..To evaluate the relationship between oral bacteria species detection and volatile sulphide compounds (VSC) concentration in the elderly...
  65. ncbi Electrochemical oxidation of 2-pyrimidinethiols and theoretical study of their dimers, disulfides, sulfenyl radicals, and tautomers
    Fillmore Freeman
    Department of Chemistry, University of California, Irvine, Irvine, California 92697 2025, USA
    J Phys Chem A 112:1643-55. 2008
    ..The APT, Mulliken (MPA), and NBO partial atomic charges are compared with the CHELPG and MKS charges that give the most consistent and similar results...
  66. ncbi Insoluble zinc, cupric and tin pyrophosphates inhibit the formation of volatile sulphur compounds
    G Jonski
    Oral Research Laboratory, Faculty of Dentistry, University of Oslo, Oslo, Norway
    Eur J Oral Sci 112:429-32. 2004
    ..Hence, the results support the experimental hypothesis. Sulphide ions are obviously very strong ligands for these metal ions...
  67. ncbi Prevalence of oral malodor and the relationship with habitual mouth breathing in children
    Takashi Kanehira
    Department of Oral Health Science, Hokkaido University, Graduate School of Dental Medicine, Sapporo, Japan
    J Clin Pediatr Dent 28:285-8. 2004
    ..Habitual mouth breathing was a factor contributing to oral malodor. Oral malodor was not significantly correlated with plaque index, history of caries or frequency of toothbrushing...
  68. ncbi Generation pattern of sulfur containing gases from anaerobically digested sludge cakes
    John T Novak
    Virginia Polytechnic Institute and State University, Blacksburg 24061, USA
    Water Environ Res 78:821-7. 2006
    ..The main odor-causing chemicals were volatile sulfur compounds, which included hydrogen sulfide, methanethiol, and dimethyl sulfide...
  69. ncbi Comparison of ninhydrin method of detecting amine compounds with other methods of halitosis detection
    K Iwanicka-Grzegorek
    Department of Conservative Dentistry, Medical University of Warsaw, Warsaw, Poland
    Oral Dis 11:37-9. 2005
    ..Therefore, statistical correlation between concentrations of volatile sulphur compounds (VSCs) and low-molecular-weight amines should be expected...
  70. ncbi Reaction mechanisms and kinetics for the oxidations of dimethyl sulfide, dimethyl disulfide, and methyl mercaptan by the nitrate radical
    Justin Jee
    Department of Chemistry and Biochemistry, California State University, Fullerton, 92834, USA
    J Phys Chem A 110:7682-9. 2006
    This study examines the initial oxidation routes of the three major reduced sulfur compounds (CH(3)SH, CH(3)SCH(3), and CH(3)SSCH(3)) by the nitrate radical using density functional and ab initio methods...
  71. ncbi Cycling of volatile organic sulfur compounds in anaerobically digested biosolids and its implications for odors
    Matthew J Higgins
    Department of Civil and Environmental Engineering, Bucknell University, Lewisburg, Pennsylvania 17837, USA
    Water Environ Res 78:243-52. 2006
    ..of this research were to elucidate the mechanisms for production and degradation of volatile organic sulfur compounds (VOSCs), key odor causing compounds produced by biosolids...
  72. ncbi Inhibitory effect of Weissella cibaria isolates on the production of volatile sulphur compounds
    Mi Sun Kang
    Department of Microbiology and Immunology, School of Medicine, Chonnam National University, Gwangju, Korea
    J Clin Periodontol 33:226-32. 2006
    ..The objective of this study was to characterize the inhibitory effects of Weissella cibaria isolates on volatile sulphur compounds (VSC) production both in vitro and in vivo...
  73. ncbi A review of the current literature on aetiology and measurement methods of halitosis
    Annemiek M W T van den Broek
    Department of Oral and Maxillofacial Surgery and Special Dental Care, Erasmus University Medical Centre, Rotterdam, The Netherlands
    J Dent 35:627-35. 2007
    ..This work reviews the current knowledge of aetiology and measurement methods of halitosis...
  74. ncbi Use of a novel group of oral malodor measurements to evaluate an anti-oral malodor mouthrinse (TriOralTM) in humans
    Don P Codipilly
    Department of Oral Biology and Pathology, State University of New York Stony Brook, NY, USA
    J Clin Dent 15:98-104. 2004
    ....
  75. ncbi A new portable sulfide monitor with a zinc-oxide semiconductor sensor for daily use and field study
    Naoko Tanda
    Department of Preventive Dentistry, Tohoku University Hospital, 4 1 Seiryo machi Aoba ku Sendai 980 8575, Japan
    J Dent 35:552-7. 2007
    ..For measuring oral malodor in daily clinical practice and in field study, we developed and evaluated a highly sensitive portable monitor system...
  76. ncbi Oral malodor-related parameters in the Chinese general population
    Xue Nan Liu
    Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Periodontol 33:31-6. 2006
    ..To estimate the prevalence of halitosis in the Chinese population and to assess the relationships between halitosis and oral health, social and behavioural factors...
  77. ncbi Bad breath tied to tongue
    Bernard Dixon
    Lancet Infect Dis 5:672. 2005
  78. ncbi [Impact of smoking on the content of volatile sulfur compounds]
    Yi Jun Gao
    Zhong Nan Da Xue Xue Bao Yi Xue Ban 29:492-3. 2004
  79. ncbi Association between oral malodor and measurements obtained using a new sulfide monitor
    Praweena Sopapornamorn
    Department of Oral Health Promotion, Graduate School, Tokyo Medical and Dental University, 1 5 45 Yushima, Tokyo, Japan
    J Dent 34:770-4. 2006
    The purpose of this study was to evaluate the ability of a new volatile sulfur compounds (VSCs) monitor to assess oral malodor in subjects and compare its performance with those of organoleptic testing and gas chromatography.
  80. ncbi Assessing the relationship between concentrations of malodor compounds and odor scores from judges
    John Greenman
    Centre for Research in Biomedicine, Faculty of Applied Sciences, University of the West of England, Bristol, England
    J Am Dent Assoc 136:749-57. 2005
    ....
  81. ncbi Halitosis associated volatiles in breath of healthy subjects
    Sandra Van den Velde
    Department of Periodontology, Catholic University of Leuven, Kapucijnenvoer 33, 3000 Leuven, Belgium
    J Chromatogr B Analyt Technol Biomed Life Sci 853:54-61. 2007
    ..Halitosis can have an intra- or extra-oral origin. In all cases, bad breath is caused by the presence of volatile organic compounds originating from the mouth or the expired air. They can be specific for certain diseases or infections...
  82. ncbi Clinical comparison of a new manual toothbrush on breath volatile sulfur compounds
    Malcolm I Williams
    Oral Care Advanced Technology, Colgate Palmolive Company Technology Center, Piscataway, New Jersey, USA
    Compend Contin Educ Dent 25:22-7. 2004
    ..and a battery-powered toothbrush (Crest SpinBrush PRO) for their ability to reduce overnight volatile sulfur compounds (VSC) associated with oral malodor. The study followed a four-period crossover design...
  83. ncbi Is transmission of bacteria that cause halitosis from pets to humans possible?
    E Iwanicka-Grzegorek
    Department of Conservative Dentistry, Medical University of Warsaw, Warsaw, Poland
    Oral Dis 11:96-7. 2005
    ..Therefore, the possible correlation between halitosis and regular contact of dental patients with pet animals was the aim of the presented study...
  84. ncbi Association among bad breath, body mass index, and alcohol intake
    M Rosenberg
    Department of Oral Biology, Goldschleger School of Dental Medicine, School of Public Health, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    J Dent Res 86:997-1000. 2007
    ..601; when introduced together with Halimeter and beta-galactosidase scores, the correlation rose to R = 0.843. The results suggest that alcohol intake and BMI may be factors that help predict oral malodor...
  85. ncbi Effect of a triclosan/PVM/MA copolymer/fluoride dentifrice on volatile sulfur compounds in vitro
    S Pilch
    Advanced Technology Oral Care, Colgate Palmolive Company Technology Center, Piscataway, NJ 088855 1343, USA
    Oral Dis 11:57-60. 2005
    ..in vitro efficacy of a triclosan/PVM/MA copolymer/fluoride (TCF) dentifrice against the formation of volatile sulfur compounds (VSC) as well as the growth of H2S-producing bacteria...
  86. ncbi Quantification of trace volatile sulfur compounds in milk by solid-phase microextraction and gas chromatography-pulsed flame photometric detection
    P A Vazquez-Landaverde
    Department of Food Science and Technology, Oregon State University, Corvallis 97331, USA
    J Dairy Sci 89:2919-27. 2006
    Volatile sulfur compounds have been reported to be responsible for the sulfurous off-flavors generated during the thermal processing of milk; however, their analysis has been a challenge due to their high reactivity, high volatility, and ..
  87. ncbi Impact of mouthrinses on morning bad breath in healthy subjects
    M D Carvalho
    Department of Prosthodontics and Periodontics, Faculty of Dentistry of Piracicaba, University of Campinas, Piracicaba, SP, Brazil
    J Clin Periodontol 31:85-90. 2004
    ..03% triclosan, 0.12% chlorhexidine gluconate, 0.05% cetylpyridinium chloride and essential oils) on morning breath when compared with a positive and a negative control...
  88. ncbi Simultaneous measurement of volatile sulfur compounds using ascorbic acid for oxidant removal and gas chromatography-flame photometric detection
    Y Inomata
    Solar Terrestrial Environmental Laboratory, Nagoya-University, Japan
    J Chromatogr A 864:111-9. 1999
    A method for the simultaneous measurement of volatile sulfur compounds (COS, H2S, CS2, CH3SH, DMS) is established with preconcentration and GC-flame photometric detection (FPD)...
  89. ncbi The relationship between volatile sulfur compounds and major halitosis-inducing factors
    Chae Hoon Lee
    Department of Oral Medicine and Oral Diagnosis, College of Dentistry, Seoul National University, Seoul, Korea
    J Periodontol 74:32-7. 2003
    ..conditions have been reported to be major halitosis-inducing factors, the relationship between volatile sulfur compounds (VSC) and these 2 major factors is not yet fully understood...
  90. ncbi The significance of the source of zinc and its anti-VSC effect
    G Rolla
    Faculty of Dentistry, University of Oslo, Blindern, Norway
    Int Dent J 52:233-5. 2002
    ..The anti-VSC (volatile sulphur compounds) effect of zinc is known to be associated with free zinc ions...
  91. ncbi Variation in oral volatile sulphur compound formation
    Alix Young
    Department of Cariology, Oral Research Laboratory, Faculty of Dentistry, University of Oslo, Norway
    Acta Odontol Scand 60:321-4. 2002
    ..It is not known, however, to what extent the level of VSC in mouth air is a stable, individual characteristic over time...
  92. ncbi A study of triclosan and its solubilizers as inhibitors of oral malodour
    Alix Young
    Department of Cariology, Faculty of Dentistry, University of Oslo, Oslo, Norway
    J Clin Periodontol 29:1078-81. 2002
    ..It is known that the detergents or organic solvents used to solubilize lipid-soluble triclosan can affect the biological activities exhibited by this molecule, such as its antibacterial, antiplaque, and anti-inflammatory effects...
  93. ncbi The relationship of oral malodor in patients with or without periodontal disease
    Luciene Cristina Figueiredo
    Paulista University, Department of Health Sciences, , , Brazil
    J Periodontol 73:1338-42. 2002
    BACKGROUND: Halitosis has been correlated with the concentration of volatile sulfur compounds (VSC) produced in the oral cavity by metabolic activity of bacteria colonizing the periodontal area and the dorsum of the tongue...
  94. ncbi Oral concentration of volatile sulphur compounds in stressed rats
    E Kurihara
    Dental School of State University of Maringa UEM, Maringa, PR, Brazil
    Stress 5:295-8. 2002
    ..Also, the animal experimental design may represent a new approach to research concerning the relationship between halitosis and stress...
  95. ncbi A clinical study to assess the breath protection efficacy of denture adhesive
    Graham J Myatt
    Procter and Gambles Rusham Park Technical Centre, Surrey, UK
    J Contemp Dent Pract 3:1-9. 2002
    ..measured at baseline and at 3 and 6 hours after the start of each treatment period via monitoring of volatile sulfur compounds (VSCs) using a halimeter and second-person organoleptic grading...
  96. ncbi [Origin and treatment of bad breath]
    B Debaty
    Rev Med Liege 57:324-9. 2002
    ..These diseases are the most important cause of tooth loss after the age of thirty-five, with progressive destruction of supporting tissues of the teeth...
  97. ncbi Halitosis in medicine: a review
    Albert Tangerman
    Department of Gastroenterology and Liver Diseases, University Medical Center Nijmegan, The Netherlands
    Int Dent J 52:201-6. 2002
    ..The methods of analysis of halitosis are critically reviewed. Attention is also given to odour characterisation of various odourants...
  98. ncbi Comparative analysis of some mouthrinses on the production of volatile sulfur-containing compounds
    Cassiano Kuchenbecker Rosing
    Clinical Dental laboratory, Faculty of Dentistry, University of Oslo, Norway
    Acta Odontol Scand 60:10-2. 2002
    ..It may be concluded that some commercial mouthrinses are markedly less effective than a simple and cheap solution of zinc acetate...
  99. ncbi The oral anti-volatile sulphur compound effects of zinc salts and their stability constants
    Alix Young
    Faculty of Dentistry, University of Oslo, Norway
    Eur J Oral Sci 110:31-4. 2002
    ..Alternative ligands. with stronger affinity for Zn than the ligands in the lozenges, must be present in the oral cavity to explain these results. It is suggested that the sulphide ion may serve this function...
  100. ncbi A multifactorial investigation of the ability of oral health care products (OHCPs) to alleviate oral malodour
    C J Silwood
    Room AW518, Medical Unit, 5th Floor, Alexandra Wing, Royal London Hospital, London E1 1BB, UK
    J Clin Periodontol 28:634-41. 2001
    ..CONCLUSIONS: We therefore conclude that oral health care products containing such oxohalogen oxidants may provide a useful therapeutic strategy for the treatment of oral malodour...
  101. ncbi Assessment of newly developed tongue sulfide probe for detecting oral malodor
    M Morita
    Department of Preventive Dentistry, Okayama University Dental School, Japan
    J Clin Periodontol 28:494-6. 2001
    ..5. Oral malodor was assessed by measuring the level of volatile sulfur compounds in mouth air, as well as by the organoleptic method. The pS levels were 0.03 +/- 0.11, 0.20 +/- 0.41 and 0...

Research Grants45

  1. Catalytic Approach to Treatment of Cyanide Poisoning
    SIGRIDUR G SUMAN; Fiscal Year: 2010
    ..The specific aims for this work are to (1) develop molybdenum-sulfur compounds to catalytically serve as sulfane sulfur transfer agents;(2) develop a non-toxic cysteine-bearing polymer ..
  2. Methionine Recycling Pathways in Klebsiella
    Jeffrey Lawrence; Fiscal Year: 2006
    ..where sulfur may be limiting, and may play significant roles in recycling abundant global pools of organic sulfur compounds. Using genetic and molecular methods, these recycling pathways will be examined...
  3. DETECTION OF BIOMOLECULES BY CHEMILUMINESCENCE
    NEIL DANIELSON; Fiscal Year: 1990
    ..studies of Ru(bpy)3+3 chemiluminescence involving the mechanism of this reaction with both amines and sulfur compounds. Wide bore capillary GC will be used to quantify the suspected products...
  4. SYNTHESIS ANTI-HIV AGENTS THAT TARGET ZINC FINGERS
    MARK WELKER; Fiscal Year: 2000
    ..Two are anti-HIV-1 active at concentrations (6 mM) which are lower than the best five or six membered ring sulfur compounds (NSC 661126 & 624151) they have screened to date from NCI's chemical repository...
  5. Structure and Mechanisms of Flavin Monooxygenases
    David Ballou; Fiscal Year: 2005
    ..Extensive use will also be made of artificial flavins introduced into the enzymes in place of the natural flavins, as probes both of active site structure and mechanism. ..
  6. Nitric oxide reactivity with synthetic iron-sulfur clusters
    ZACHARY TONZETICH; Fiscal Year: 2009
    ..Preparation of the target iron-sulfur compounds will involve new synthetic methodologies as well as existing protocols for the preparation of iron-sulfur ..
  7. SYNTHESIS OF CHLOROPEPTINS, GP120 CD4 BINDING INHIBITORS
    AMOS SMITH; Fiscal Year: 2001
    ..abstract_text> ..
  8. SYNTHESIS OF SPONGISTATIN ANTITUMOR AGENTS
    AMOS SMITH; Fiscal Year: 2007
    ..abstract_text> ..
  9. Design and Synthesis of HIV-1 Protease Inhibitors
    AMOS SMITH; Fiscal Year: 2004
    ....
  10. NMR systems : 2 Bruker Avance 500 Consoles
    AMOS SMITH; Fiscal Year: 2006
    ..The areas of public health research include, among others, cancer, infectious diseases, neurodegenerative diseases such as Alzheimer's disease, and heart and cardiovascular disease. [unreadable] [unreadable] [unreadable]..
  11. ASYMMETRIC SYNTHESIS OF BIOACTIVE PRIMARY AMINES
    FRANKLIN DAVIS; Fiscal Year: 2006
    ....
  12. Asymmetric Synthesis of Amino Acids and Amino Phosphonic Acids
    FRANKLIN DAVIS; Fiscal Year: 2007
    ..The photodesulfmylation of sulfinamides represents an important new protocol, not requiring acids or bases, for the removal of the valuable amine N-sulfinyl protecting group. ..
  13. Syntheses of Amino Acids and Amino Phosphonic Acids
    FRANKLIN DAVIS; Fiscal Year: 2005
    ..Targets include cyclic, unsaturated, and, beta substituted derivatives (beta amino, beta hydroxy, and beta fluoro). ..
  14. Pseudopteroxazole and Related Antitubercular Agents
    Michael Harmata; Fiscal Year: 2007
    ..More generally, the methodology to be developed should have extremely broad impact, as it can be applied to the generation of stereogenic centers in a large number of compounds of biological and medicinal interest. ..
  15. SYNTHESIS OF ANTICANCER AGENTS
    K C Nicolaou; Fiscal Year: 2010
    ..abstract_text> ..
  16. Enabling Technologies for Combinatorial Chemistry
    K Nicolaou; Fiscal Year: 2005
    ..abstract_text> ..
  17. TOTAL SYNTHESIS OF AZADIRACHTIN
    K Nicolaou; Fiscal Year: 2008
    ..The proposed work is expected to impact the general areas of pharmaceutical and agricultural research, and infectious diseases in particular, through discoveries in synthetic organic chemistry and chemical biology. ..
  18. TOTAL SYNTHESIS OF NATURAL PRODUCTS
    K Nicolaou; Fiscal Year: 2002
    ..3] sigmatropic rearrangement and a radical based ring closure to form the bicyclic skeleton. ..
  19. TOTAL SYNTHESIS OF APOPTOLIDIN
    K Nicolaou; Fiscal Year: 2004
    ..The proposed work is expected to have significant impact in the area of cancer chemotherapy and should provide enabling technologies and tools for biology and medicine. ..
  20. BENZANNULATION APPROACH TO BIARYL ETHERS
    Michael Harmata; Fiscal Year: 2001
    ..abstract_text> ..
  21. Guided Pocket Recolonization (GPR) in Periodontitis
    Marc Quirynen; Fiscal Year: 2004
    ..Clinical data will be collected after 2, 4, 6, 8 and 12 weeks. The results should indicate the possible role for commensal organisms in periodontal disease and subgingival biofilm formation. ..
  22. Catalytic Processes for Selective Organic Synthesis
    GARY MOLANDER; Fiscal Year: 2005
    ..4) Carbometalation/cyclization reactions will be explored utilizing organochromium species. 5) Ligands and catalytic systems designed for asymmetric synthesis will be explored. ..
  23. Nutritional Regulation of y-Glutamylcysteine Synthetase
    MARTHA STIPANUK; Fiscal Year: 2007
    ..Capacity for GSH synthesis, availability of the precursor amino acid cysteine, and steady-state GSH levels all contribute to the body's ability to defend itself against oxidative or chemical stressors. ..
  24. MECHANISM(S) OF CHEMICAL LEUKEMOGENESIS
    Richard Irons; Fiscal Year: 2002
    ..A. in specific sub-populations of CD34+ human BM cells. Finally, patterns of gene expression will be correlated with genotype, phenotype and functional clonogenic response in BM cells obtained from patients with MDS or evolving sAML. ..
  25. Agilent 5973 GC/MS System
    GARY MOLANDER; Fiscal Year: 2002
    ..Our current lack of such instrumentation negatively affects the ability to carry out many of these studies. This critical capability, in the form of an instrument for everyday analysis, is urgently needed. ..
  26. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  27. Stereochemistry of Elimination and Proton Transfer
    JERRY MOHRIG; Fiscal Year: 2002
    ..Carleton College undergraduate chemistry majors will carry out the research. The principal investigator has had substantial experience in crafting successful undergraduate research experiences over his teaching career. ..
  28. ARYL AND ALCOHOL SULFOTRANSFERASES IN DRUG METABOLISM
    Michael W Duffel; Fiscal Year: 2010
    ..Moreover, specific aim #1 has additional particular relevance to understanding and more accurately predicting the metabolism of Tamoxifen, a widely used antitumor agent and chemopreventive agent for estrogen-dependent breast cancer. ..
  29. Chronological Age-Dependent Genomic Instability in Yeast
    Valter D Longo; Fiscal Year: 2010
    ..Thus, chronologically aging S. cerevisiae can serve as a model to identify genes that regulate genomic instability and understand the mechanisms responsible for age-dependent DNA mutations and cancer in mammals. ..
  30. SYNTHESIS OF FUSED HETEROCYCLIC COMPOUNDS
    Albert Padwa; Fiscal Year: 2002
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..
  31. Etiology and Prevention of Oral Cancer
    Karam El Bayoumy; Fiscal Year: 2007
    ..By identifying critical intervention targets in tongue tumorigenesis, it should be possible to minimize the gap between basic research and clinical application, and lead to translational clinical interventions. ..
  32. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  33. 4 iron-4sulfur Clusters in Aging and Alzheimer's Disease
    Valter Longo; Fiscal Year: 2004
    ..abstract_text> ..
  34. The Effect of a Probiotic on Hepatic Steatosis
    Steven Solga; Fiscal Year: 2004
    ..If the efficacy of probiotics is established one type of chronic liver disease, the possibility that similar biological therapies might benefit other chronic inflammatory states would merit further evaluation. ..
  35. Identifying the Antiplatelet Compounds of Garlic Ex Vivo
    Larry Lawson; Fiscal Year: 2005
    ..abstract_text> ..
  36. Inhibition of Tubercular Mycothiol Pathways
    Spencer Knapp; Fiscal Year: 2004
    ..The most active compounds will be taken as leads for further analogue development and for increasing the potency, specificity, bioavailability, and metabolic stability in M. tuberculosis itself. ..
  37. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  38. TOBACCO CARCINOGENESIS AND CHEMOPREVENTION
    Karam El Bayoumy; Fiscal Year: 2005
    ..e., selenium compounds, vitamins, and EGCG. ..
  39. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  40. Role of trypsinogen sulfation in alcoholic pancreatitis
    Miklos Sahin Toth; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  41. H2S PRODUCTION AND VIRULENCE OF TREPONEMA DENTICOLA
    Lianrui Chu; Fiscal Year: 2007
    ..In addition, the existence of volatile sulfur compounds produced at destructive sites is a characteristic feature of periodontal diseases, with H2S as a major ..
  42. HETEROCYCLIC RING COMPOUNDS FOR ALKALOID SYNTHESIS
    Albert Padwa; Fiscal Year: 2007
    ..The generation of biologically active compounds by new synthetic methods remains an important part of both health related and chemical research. ..