dietary sodium chloride

Summary

Summary: Sodium chloride used in foods.

Top Publications

  1. ncbi Plasma sodium and hypertension
    Hugh E de Wardener
    Department of Clinical Chemistry, Imperial College, Charing Cross Hospital Campus, London, United Kingdom
    Kidney Int 66:2454-66. 2004
  2. ncbi Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases
    Pierre Meneton
    Institut National de la Santé et de la Recherche Médicale U367, Département de Santé Publique et d Informatique Médicale, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
    Physiol Rev 85:679-715. 2005
  3. ncbi Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress
    Miki Nagase
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hypertension 50:877-83. 2007
  4. ncbi Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase
    Chagriya Kitiyakara
    Division of Nephrology and Hypertension and Cardiovascular Kidney Institute, Georgetown University, Washington, DC 20007, USA
    J Am Soc Nephrol 14:2775-82. 2003
  5. ncbi Iodine deficiency in 2007: global progress since 2003
    Bruno de Benoist
    Department of Nutrition for Health and Development, World Health Organization, CH 1211 Geneva 27, Switzerland
    Food Nutr Bull 29:195-202. 2008
  6. ncbi Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Rd, Norfolk, VA 23507, USA
    Am J Physiol Renal Physiol 285:F619-28. 2003
  7. ncbi Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
  8. ncbi The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives
    Peter Laurberg
    Department of Endocrinology and Medicine, Aalborg Hospital, DK 9000 Aalborg, Denmark
    Eur J Endocrinol 155:219-28. 2006
  9. ncbi Risks of iodine-induced hyperthyroidism after correction of iodine deficiency by iodized salt
    F Delange
    International Council for Control of Iodine Deficiency Disorders, Brussels, Belgium
    Thyroid 9:545-56. 1999
  10. pmc Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats
    Marlene F Shehata
    Cardiovasc Diabetol 7:7. 2008

Detail Information

Publications199 found, 100 shown here

  1. ncbi Plasma sodium and hypertension
    Hugh E de Wardener
    Department of Clinical Chemistry, Imperial College, Charing Cross Hospital Campus, London, United Kingdom
    Kidney Int 66:2454-66. 2004
    ..We suggest that a small increase in plasma sodium may be part of the mechanisms whereby dietary salt increases the blood pressure...
  2. ncbi Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases
    Pierre Meneton
    Institut National de la Santé et de la Recherche Médicale U367, Département de Santé Publique et d Informatique Médicale, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
    Physiol Rev 85:679-715. 2005
    ..Thus chronic exposure to a high-salt diet appears to be a major factor involved in the frequent occurrence of hypertension and cardiovascular diseases in human populations...
  3. ncbi Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress
    Miki Nagase
    Department of Nephrology and Endocrinology, University of Tokyo Graduate School of Medicine, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    Hypertension 50:877-83. 2007
    ..Salt reduced circulating aldosterone but caused renal MR activation at least partially via induction of oxidative stress, and eplerenone effectively improved the nephropathy...
  4. ncbi Salt intake, oxidative stress, and renal expression of NADPH oxidase and superoxide dismutase
    Chagriya Kitiyakara
    Division of Nephrology and Hypertension and Cardiovascular Kidney Institute, Georgetown University, Washington, DC 20007, USA
    J Am Soc Nephrol 14:2775-82. 2003
    ..Thus, salt intake enhances generation of O(2)(.-) accompanied by enhanced renal expression and activity of NAD(P)H oxidase with diminished renal expression of IC- and Mn-SOD...
  5. ncbi Iodine deficiency in 2007: global progress since 2003
    Bruno de Benoist
    Department of Nutrition for Health and Development, World Health Organization, CH 1211 Geneva 27, Switzerland
    Food Nutr Bull 29:195-202. 2008
    ..Iodine deficiency is a global public health problem, and estimates of the extent of the problem were last produced in 2003...
  6. ncbi Effect of salt on hypertension and oxidative stress in a rat model of diet-induced obesity
    Anca D Dobrian
    Department of Physiological Sciences, Eastern Virginia Medical School, 700W Olney Rd, Norfolk, VA 23507, USA
    Am J Physiol Renal Physiol 285:F619-28. 2003
    ..Also, the OP rats on high salt displayed adipocyte hypertrophy and increased leptin production...
  7. ncbi Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage
    Norbert Henke
    Medical Faculty of the Charite, Franz Volhard Clinic, HELIOS Klinikum Berlin, Germany
    Circ Res 101:268-76. 2007
    ..We conclude that in vivo NF-kappaB suppression in endothelial cells stops a signaling cascade leading to reduced hypertension-induced renal damage despite high blood pressure...
  8. ncbi The Danish investigation on iodine intake and thyroid disease, DanThyr: status and perspectives
    Peter Laurberg
    Department of Endocrinology and Medicine, Aalborg Hospital, DK 9000 Aalborg, Denmark
    Eur J Endocrinol 155:219-28. 2006
    ..p.m. iodine) was initiated in 2000/2001. The Danish investigation on iodine intake and thyroid disease (DanThyr) is the monitoring of the iodine fortification program...
  9. ncbi Risks of iodine-induced hyperthyroidism after correction of iodine deficiency by iodized salt
    F Delange
    International Council for Control of Iodine Deficiency Disorders, Brussels, Belgium
    Thyroid 9:545-56. 1999
    ..In conclusion, the risk of IIH after correction of iodine deficiency is closely related to a recent excessive increment of iodine supply...
  10. pmc Genetic and dietary salt contributors to insulin resistance in Dahl salt-sensitive (S) rats
    Marlene F Shehata
    Cardiovasc Diabetol 7:7. 2008
    ....
  11. ncbi Effects of dietary sodium chloride on health parameters in mature cats
    Hui Xu
    Nestle Purina Pet Care Company, Checkerboard Square, St Louis, MO 63164, USA
    J Feline Med Surg 11:435-41. 2009
    ..5% of the diet dm is not harmful to healthy cats...
  12. ncbi Effects of dietary sodium chloride intake on renal function and blood pressure in cats with normal and reduced renal function
    Chollada Buranakarl
    Department of Physiology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, 10330, Thailand
    Am J Vet Res 65:620-7. 2004
    ..To determine effects of variations in dietary intake of sodium chloride (NaCl) on systemic arterial blood pressure (ABP) in cats with normal and reduced renal function...
  13. ncbi Prevalence of goiter in children 6 to 12 years of age in Ethiopia
    Cherinet Abuye
    Ethiopian Health and Nutrition Research Institute, Addis Ababa, Ethiopia
    Food Nutr Bull 28:391-8. 2007
    ..Iodine-deficiency disorders are a major public health problem in Ethiopia. In conjunction with implementing control programs, baseline information needs to be established...
  14. ncbi Evaluation of a rapid protocol for the assessment of salt sensitivity against the blood pressure response to dietary sodium chloride restriction
    F Galletti
    Department of Clinical and Experimental Medicine, Federico II University of Naples, Medical School, Italy
    Am J Hypertens 10:462-6. 1997
    ..A validation of this test in a larger patient population may be advisable...
  15. ncbi The time course of salt-induced hypertension, and why it matters
    B N Van Vliet
    Division of Biomedical Sciences, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Int J Obes (Lond) 32:S35-47. 2008
    ....
  16. ncbi Sodium intake of 1 to 5-year-old children: the STRIP project. The Special Turku Coronary Risk Factor Intervention Project
    T Heino
    Cardiorespiratory Research Unit, University of Turku, Finland
    Acta Paediatr 89:406-10. 2000
    ..To avoid excessive sodium intake in children, dietary counselling should include information about salt use, and food manufacturers should be encouraged to provide more low-sodium products...
  17. ncbi Salt intake, endothelial cell signaling, and progression of kidney disease
    Paul W Sanders
    Nephrology Research and Training Center, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 0007, USA
    Hypertension 43:142-6. 2004
    ..The data support an important benefit to reduction of salt intake in the setting of chronic kidney disease...
  18. ncbi Body mass index and angiotensin-dependent control of the renal circulation in healthy humans
    Sofia B Ahmed
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Hypertension 46:1316-20. 2005
    ..Weight loss should be considered in the overweight or obese patient for renal protection...
  19. ncbi Dietary sodium chloride intake independently predicts the degree of hyperchloremic metabolic acidosis in healthy humans consuming a net acid-producing diet
    Lynda A Frassetto
    Dept of Medicine and General Clinical Research Center, University of California, San Francisco, CA 94143, USA
    Am J Physiol Renal Physiol 293:F521-5. 2007
    ..Assuming a causal relationship, over their respective ranges of variation, NaCl has approximately 50-100% of the acidosis-producing effect of the diet net acid load...
  20. ncbi Goiter rate, serum thyrotropin, thyroid autoantibodies and urinary iodine concentration in Tehranian adults before and after national salt iodization
    P Heydarian
    Department of Endocrinology and Metabolism, Tehran University of Medical Sciences, Tehran, Iran
    J Endocrinol Invest 30:404-10. 2007
    ..Benefits of iodine supplementation far outweigh its hazards in Tehranian adults...
  21. ncbi Protective effect of potassium against the hypertensive cardiac dysfunction: association with reactive oxygen species reduction
    Hiromitsu Matsui
    Department of Internal Medicine, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Hypertension 48:225-31. 2006
    ..Sufficient potassium supplementation might be an attractive strategy for cardiac protection, especially in the salt-sensitive hypertensive subjects...
  22. pmc Long term effects of dietary sodium reduction on cardiovascular disease outcomes: observational follow-up of the trials of hypertension prevention (TOHP)
    Nancy R Cook
    Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    BMJ 334:885-8. 2007
    ..To examine the effects of reduction in dietary sodium intake on cardiovascular events using data from two completed randomised trials, TOHP I and TOHP II...
  23. ncbi Salt and blood pressure in children and adolescents
    F J He
    Blood Pressure Unit, Cardiac and Vascular Sciences, St George s University of London, London, UK
    J Hum Hypertens 22:4-11. 2008
    ..The consistent finding of our present analysis of a random sample of free-living individuals with that from controlled salt reduction trials provides further support for a reduction in salt intake in children and adolescents...
  24. ncbi Birth weight relates to salt sensitivity of blood pressure in healthy adults
    Michiel P de Boer
    Department of Internal Medicine, Institute for Cardiovascular Research Vrije Universiteit, University Medical Center Amsterdam, The Netherlands
    Hypertension 51:928-32. 2008
    ..Birth weight is associated with salt sensitivity of blood pressure, and this may play a role in the maintenance of elevated blood pressure in individuals with a low birth weight...
  25. ncbi Dietary salt reduction in hypertension--what is the evidence and why is it still controversial?
    G S Chrysant
    University of Alabama at Birmingham, Department of Medicine, Vascular Biology and Hypertension Program, 35294 0012, USA
    Prog Cardiovasc Dis 42:23-38. 1999
    ..This paper will review the definition and methods used in determining salt sensitivity, the evidence linking sodium intake and target organ damage, and modern studies of salt and blood pressure...
  26. ncbi Distinct rapid and slow phases of salt-induced hypertension in Dahl salt-sensitive rats
    Bruce N Van Vliet
    Basic Medical Science Division, Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    J Hypertens 24:1599-606. 2006
    ..To test the hypothesis that Dahl salt-sensitive (Dahl-S) rats exhibit distinct and separable phases of salt sensitivity...
  27. ncbi NADPH oxidase in the renal medulla causes oxidative stress and contributes to salt-sensitive hypertension in Dahl S rats
    Norman E Taylor
    Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA
    Hypertension 47:692-8. 2006
    ..We conclude that excess renal medullary superoxide production in SS rats contributes to salt-induced hypertension, and NADPH oxidase is the major source of the excess superoxide...
  28. ncbi Sustainable universal salt iodization in low-income countries - time to re-think strategies?
    V D Assey
    IDD Control Program, Tanzania Food and Nutrition Centre TFNC, Dar es Salaam, Tanzania
    Eur J Clin Nutr 62:292-4. 2008
    ..Sustained iodine deficiency control requires sustainable mechanisms for iodine supplementation. We aim to describe the status of salt iodation machines, salt producers' experiences and quality of salt produced in Tanzania...
  29. ncbi Persistence of iodine deficiency in Gangetic flood-prone area, West Bengal, India
    Tapas Kumar Sen
    Department of Health and Family Welfare, Govt of West Bengal, India
    Asia Pac J Clin Nutr 15:528-32. 2006
    ..However, the persistence of non-iodised salt consumption indicates that an intensification of universal salt iodisation program is needed...
  30. ncbi Remaining challenges in Tanzania's efforts to eliminate iodine deficiency
    Vincent D Assey
    Tanzania Food and Nutrition Centre, Dar es Salaam, Tanzania
    Public Health Nutr 10:1032-8. 2007
    ..To determine iodine levels in salt and iodine deficiency prevalence in school-aged children in 16 districts in Tanzania with previous severe iodine deficiency...
  31. pmc Important genetic checkpoints for insulin resistance in salt-sensitive (S) Dahl rats
    Marlene F Shehata
    Department of Cellular and Molecular Medicine, University of Ottawa Heart Institute, K1Y 4W7, Ottawa, ON, Canada
    Cardiovasc Diabetol 7:19. 2008
    ....
  32. ncbi Assessing iodine status and monitoring progress of iodized salt programs
    Michael B Zimmermann
    Laboratory for Human Nutrition, Institute for Food Science and Nutrition, Swiss Federal Institute of Technology Zurich, CH 8803 Ruschlikon, Switzerland
    J Nutr 134:1673-7. 2004
    ..A recent cohort study demonstrated the vulnerability of children in IDD-affected areas to even short-term lapses in iodized salt programs...
  33. ncbi Iodine deficiency disorders among school children of Dakshin Dinajpur District, West Bengal
    D K Das
    Department of Community Medicine, R G Kar Medical College and Hospital, Kolkata
    Indian J Public Health 49:68-72. 2005
    ..The district is in the transition phase from iodine-deficient to iodine-sufficient. Measures are to be sustained for successful transition towards elimination...
  34. ncbi Progress in salt iodization and improved iodine nutrition in China, 1995--99
    Jinkou Zhao
    Jiangsu Provincial Center for Disease Control and Prevention in Nanjing, China
    Food Nutr Bull 25:337-43. 2004
    ..Policy recommendations include improvement of quality assurance by salt manufacturers, along with a modest reduction in the mandated salt iodization levels...
  35. ncbi Introduction of iodized salt to severely iodine-deficient children does not provoke thyroid autoimmunity: a one-year prospective trial in northern Morocco
    Michael B Zimmermann
    The Human Nutrition Laboratory, Swiss Federal Institute of Technology, Zurich, Switzerland
    Thyroid 13:199-203. 2003
    ..Rapid introduction of iodized salt does not provoke significant thyroid autoimmunity in severely iodine-deficient children followed for 1 year...
  36. ncbi Rural and semi-urban differences in salt intake, and its dietary sources, in Ashanti, West Africa
    Sally M Kerry
    Department of Community Health Sciences, St George s Hospital Medical School, Cranmer Terrace, London
    Ethn Dis 15:33-9. 2005
    ..To provide a socioeconomic profile of rural and semi-urban settings in Ashanti, West Africa and to investigate the relationship between urbanization and sources of salt in the diet...
  37. ncbi Women's iodine status and its determinants in an iodine-deficient area in the Kayes region, Mali
    Liv E Torheim
    Pedriatric Ward, Rikshospitalet, Oslo, Norway
    Public Health Nutr 8:387-94. 2005
    ..To assess iodine status and its determinants in women of childbearing age in a rural area in the Kayes region, Mali, West Africa...
  38. pmc Current global iodine status and progress over the last decade towards the elimination of iodine deficiency
    Maria Andersson
    Department of Nutrition for Health and Development, World Health Organization, Geneva, Switzerland
    Bull World Health Organ 83:518-25. 2005
    ..To estimate worldwide iodine nutrition and monitor country progress towards sustained elimination of iodine deficiency disorders...
  39. ncbi Increased salt-sensitivity in endothelial nitric oxide synthase-knockout mice
    Allison M Leonard
    Faculty of Medicine, Memorial University of Newfoundland, St John s, Newfoundland, Canada
    Am J Hypertens 19:1264-9. 2006
    ..In the present study we compared the effects of a high-salt diet on the blood pressure response of eNOS knockout (eNOS-/-) and control (eNOS+/+) mice...
  40. ncbi Goiter and other iodine deficiency disorders: A systematic review of epidemiological studies to deconstruct the complex web
    Atul Kotwal
    Management Information Systems Organization, Integrated HQ Min of Defence Army, New Delhi, India
    Arch Med Res 38:1-14. 2007
    ..This imposes specific problems and necessitates area-specific solutions instead of a universal solution, which apart from being less effective may be harmful in the long run...
  41. ncbi Iodine deficiency persists in the Zanzibar Islands of Tanzania
    V D Assey
    Tanzania Food and Nutrition Centre, Dar es Salaam, Tanzania
    Food Nutr Bull 27:292-9. 2006
    ..It is estimated that more than 1.6 billion people live in iodine-deficient environments, yet there are still some countries and areas where the prevalence of iodine-deficiency disorders is unknown...
  42. ncbi Dietary salt intake modulates progression of antithymocyte serum nephritis through alteration of glomerular angiotensin II receptor expression
    Hiroyuki Suzuki
    First Department of Medicine, Hamamatsu Univ School of Medicine, 1 20 1, Handayama, Hamamatsu 431 3192, Japan
    Am J Physiol Renal Physiol 286:F267-77. 2004
    ..Our results suggest that dietary salt intake influences progression of ATS nephritis by modulating glomerular TGF-beta1 and TbetaR expression resulting, at least in part, from altered glomerular AT1R and AT2R expression...
  43. ncbi Sustainability of a well-monitored salt iodization program in Iran: marked reduction in goiter prevalence and eventual normalization of urinary iodine concentrations without alteration in iodine content of salt
    F Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, IR Iran
    J Endocrinol Invest 31:422-31. 2008
    ..Goiter prevalence and UIC were compared 2 and 7 yr after sustained consumption of uniformly iodized salt by Iranian households...
  44. ncbi Sympatho-inhibitory action of endogenous adrenomedullin through inhibition of oxidative stress in the brain
    Megumi Fujita
    Department of Nephrology and Endocrinology, Faculty of Medicine, The University of Tokyo, 7 3 1, Hongo, Tokyo, 113 8655, Japan
    Hypertension 45:1165-72. 2005
    ..In conclusion, endogenous adrenomedullin in the brain may inhibit sympathetic activation through its antioxidant action...
  45. ncbi High-salt diet enhances insulin signaling and induces insulin resistance in Dahl salt-sensitive rats
    Takehide Ogihara
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Hypertension 40:83-9. 2002
    ....
  46. ncbi Salt-sensing mechanisms in blood pressure regulation and hypertension
    Sergei N Orlov
    Department of Medicine and Centre Hospitalier de l Université de Montréal, Montreal, Quebec, Canada
    Am J Physiol Heart Circ Physiol 293:H2039-53. 2007
    ....
  47. ncbi Policy of universal salt iodization in Bangladesh: do coastal people benefit?
    S Rasheed
    Social and Behavioural Sciences Programme, Public Health Sciences Division, ICDDR, B Centre for Health and Population Research, GPO Box 128, Dhaka 1000 Mohakhali, Dhaka 1212, Bangladesh
    J Health Popul Nutr 19:66-72. 2001
    ..Understanding of the prevalent situation will allow the policy-makers to take measures to improve the situation in the salt-producing areas...
  48. ncbi Moderate salt restriction effectively lowers blood pressure and degree of salt sensitivity is related to baseline concentration of renin and N-terminal atrial natriuretic peptide in plasma
    Olle Melander
    Department of Clinical Sciences, Malmö University Hospital and Lund University, Malmo, Sweden
    J Hypertens 25:619-27. 2007
    ..Furthermore, we tested whether the basal plasma concentration of renin or N-terminal atrial natriuretic peptide (Nt-proANP) predict the degree of salt sensitivity...
  49. ncbi Thyroid autoantibodies in women with and without thyroid disorders in an iodine-replete area
    A Aminorroaya
    Isfahan Endocrine and Metabolism Research Centre, Isfahan University of Medical Sciences, Isfahan, Islamic Republic of Iran
    East Mediterr Health J 14:325-32. 2008
    ..5% of patients with hypothyroidism, 73.6% of those with hyperthyroidism, 48.9% of those with simple goitre and 35.8% of the control group (P < 0.001). Autoimmunity may have a role in the genesis of common thyroid disorders...
  50. ncbi Importance of salt in determining blood pressure in children: meta-analysis of controlled trials
    Feng J He
    Blood Pressure Unit, Cardiac and Vascular Sciences, St George s University of London, Cranmer Terrace, London, SW17 0RE, United Kingdom
    Hypertension 48:861-9. 2006
    ..This would result in major reductions in cardiovascular disease. These results in conjunction with other evidence provide strong support for a reduction in salt intake in children...
  51. ncbi Iodine content of salt 2 years after the introduction of the universal salt iodisation legislation in Lesotho
    Masekonyela Linono Damane Sebotsa
    P Bag A78, Maseru 100, Lesotho
    Br J Nutr 93:917-22. 2005
    ..During enforcement more emphasis should be given to iodisation of coarse salt...
  52. ncbi The evaluation of the iodine content of table salt in Lesotho
    Masekonyela L D Sebotsa
    Food and Nutrition Coordinating Office, P Bag A78, Maseru, Lesotho
    Afr J Health Sci 9:139-45. 2002
    ..81.8% of the households use adequately iodised salt. This however does not meet WHO criteria for elimination of IDD as a public health problem since less than 90% of effectively iodised salt is being used at household level...
  53. ncbi Stability of salt double-fortified with ferrous fumarate and potassium iodate or iodide under storage and distribution conditions in Kenya
    Toks Oshinowo
    Department of Chemical Engineering and Applied Chemistry, University of Toronto, Ontario, Canada
    Food Nutr Bull 25:264-70. 2004
    ....
  54. pmc Cost and health consequences of reducing the population intake of salt
    R M Selmer
    National Health Screening Service, PO Box 8155 Dep, N 0033 Oslo, Norway
    J Epidemiol Community Health 54:697-702. 2000
    ..Health promotion (information campaigns), development of new industry food recipes, declaration of salt content in food and taxes on salty food/subsidies of products with less salt, were possible interventions...
  55. ncbi Dietary sodium chloride restriction enhances aortic wall lipid storage and raises plasma lipid concentration in LDL receptor knockout mice
    Sergio Catanozi
    Lipids Laboratory LIM 10, University of Sao Paulo Medical School, Brazil
    J Lipid Res 44:727-32. 2003
    ..Arterial fat storage correlated with NEFA concentrations in the LDLR KO mice alone (n = 14, P = 0.0065). Thus, dietary sodium chloride restriction enhances aortic wall lipid storage in moderately hyperlipidemic mice.
  56. ncbi Goitre prevalence, urinary iodine and salt iodisation level in a district of West Bengal, India
    Dilip Kumar Das
    RG Kar Medical College, West Bengal, India
    J Am Coll Nutr 27:401-5. 2008
    ..We carried out a study to assess the prevalence of goitre, measure urinary iodine excretion (UIE) levels and to estimate salt iodine content at the household level in Howrah district of West Bengal, India...
  57. ncbi Aldosterone in salt-sensitive hypertension and metabolic syndrome
    Toshiro Fujita
    Department of Nephrology and Endocrinology, University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo, Japan
    J Mol Med (Berl) 86:729-34. 2008
    ..Therefore, aldosterone/MR activation plays a key role not only in the development of salt-sensitive hypertension, but also in cardiovascular injury in metabolic syndrome, possibly through its function as a feed-forward system...
  58. pmc Assessment of the iodine concentration in table salt at the production stage in South Africa
    Pieter L Jooste
    Nutritional Intervention Research Unit, Medical Research Council, Cape Town, South Africa
    Bull World Health Organ 81:517-21. 2003
    ....
  59. ncbi Gestational and early postnatal dietary NaCl levels affect NaCl intake, but not stimulated water intake, by adult rats
    Kathleen S Curtis
    Department of Psychology and Program in Neuroscience, The Florida State University, Tallahassee, FL 32306 1270, USA
    Am J Physiol Regul Integr Comp Physiol 286:R1043-50. 2004
    ....
  60. ncbi Renal NF-kappaB activation and TNF-alpha upregulation correlate with salt-sensitive hypertension in Dahl salt-sensitive rats
    Jian Wei Gu
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216 4505, USA
    Am J Physiol Regul Integr Comp Physiol 291:R1817-24. 2006
    ..These findings support the hypothesis that activation of NF-kappaB and upregulation of TNF-alpha are the important renal mechanisms linking proinflammatory response to SS hypertension...
  61. ncbi Insufficient level of iodine content in household powder salt in Nepal
    Anand Ballabh Joshi
    Research Unit, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal
    Nepal Med Coll J 9:75-8. 2007
    ..6 ppm (95.0% CI= 31.7- 33.4) and 30.6 ppm respectively. In the community level, people are still using the non-iodized salt. To eliminate the IDD more efforts are required at program implementation and monitoring level...
  62. ncbi Mechanisms of insulin resistance in rat models of hypertension and their relationships with salt sensitivity
    L A Sechi
    Department of Internal Medicine, University of Udine School of Medicine, Italy
    J Hypertens 17:1229-37. 1999
    ....
  63. pmc Validation of spot-testing kits to determine iodine content in salt
    C S Pandav
    Clinical Epidemiology Unit CEU, All India Institute of Medical Sciences, New Delhi, India
    Bull World Health Organ 78:975-80. 2000
    ..Therefore, we conclude that until a valid alternative is available, the titration method should be used for monitoring the iodine content of salt at all levels, from producer to consumer, to ensure effectiveness of the programme...
  64. ncbi Goiter prevalence, urinary iodine excretion, thyroid function and anti-thyroid function and anti-thyroid antibodies after 12 years of salt iodization in Shahriar, Iran
    Fereidoun Azizi
    Endocrine Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I R Iran
    Int J Vitam Nutr Res 72:291-5. 2002
    ..Iodized salt has been distributed in the region for the past 12 years, and the present study was performed to examine the effect of iodide supplementation on indicators of iodine deficiency (IDD) and thyroid antibodies...
  65. ncbi Exendin-4 has an anti-hypertensive effect in salt-sensitive mice model
    Kunio Hirata
    Department of Medicine, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu, Shiga 520 2192, Japan
    Biochem Biophys Res Commun 380:44-9. 2009
    ..Considered together, our results indicate that exendin-4 has anti-hypertensive effects through the attenuation of angII-induced high-salt sensitivity...
  66. ncbi Iodine concentration in salt at household and retail shop levels in Shebe town, south west Ethiopia
    L Takele
    South People Nations and Nationalities People s Regional Health Bureau, Jimma, Ethiopia
    East Afr Med J 80:532-9. 2003
    ..To determine the level of iodine in the salt at the retail shop and consumption levels and assess the knowledge, attitude and practice (KAP) of food caterers and shopkeepers about iodized salt and iodine deficiency disorders (IDD)...
  67. ncbi Contribution of salt intake to insulin resistance associated with hypertension
    Takehide Ogihara
    Department of Internal Medicine, Graduate School of Medicine, University of Tokyo, 7 3 1 Hongo Bunkyo ku, Tokyo 113 8655, Japan
    Life Sci 73:509-23. 2003
    ..g., potassium supplementation and anti-oxidant administration--to the treatment of insulin resistance and hypertension...
  68. ncbi Upregulation of cortical COX-2 in salt-sensitive hypertension: role of angiotensin II and reactive oxygen species
    Edgar A Jaimes
    Department of Veterans Affairs Medical Center, Renal Division, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Am J Physiol Renal Physiol 294:F385-92. 2008
    ..These studies unveil novel mechanistic pathways that may play a role in the pathogenesis of hypertensive renal injury...
  69. ncbi Exclusion of the catechol-o-methyltransferase gene from genes contributing to salt-sensitive hypertension in dahl salt-sensitive rats
    Kazuaki Kajimoto
    Department of Epidemiology, Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 30:459-67. 2007
    ..Thus, Comt was excluded from the candidate genes contributing to salt-sensitive hypertension in DS rats. A true gene responsible for pulse pressure in this chromosome 11 region remains to be determined...
  70. ncbi N-Acetylcysteine improves renal dysfunction, ameliorates kidney damage and decreases blood pressure in salt-sensitive hypertension
    Niu Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    J Hypertens 24:2263-70. 2006
    ..Salt-sensitive hypertension in humans and experimental animals causes progressive increases in renal damage and dysfunction. The Dahl salt-sensitive (S) rat closely mimics human salt-sensitive hypertension...
  71. ncbi Immune suppression prevents renal damage and dysfunction and reduces arterial pressure in salt-sensitive hypertension
    N Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA
    Am J Physiol Heart Circ Physiol 292:H1018-25. 2007
    ..This suggests that renal infiltration of immune cells is associated with increased arterial pressure and renal damage and decreasing GFR and renal plasma flow in Dahl salt-sensitive hypertension...
  72. ncbi Effect of dietary sodium on estrogen regulation of blood pressure in Dahl salt-sensitive rats
    Wei Zheng
    Georgetown University, NW, Washington, DC 20057, USA
    Am J Physiol Heart Circ Physiol 294:H1508-13. 2008
    ..These findings have implications for women with salt-sensitive hypertension and women who are E(2) deficient, such as postmenopausal women...
  73. ncbi Immune suppression blocks sodium-sensitive hypertension following recovery from ischemic acute renal failure
    Kimberly R Pechman
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1234-9. 2008
    ..The present data indicate that infiltrating immune cells mediate or participate in the development of sodium-sensitive hypertension and renal damage in rats apparently recovered from renal I/R injury...
  74. ncbi Different effects of angiotensin receptor blockade on end-organ damage in salt-dependent and salt-independent hypertension
    Karlene Maitland
    Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Mass, USA
    Circulation 114:905-11. 2006
    ..Although angiotensin II type 1 receptor blockers have emerged as effective antihypertensive agents, it is not known how efficacious these agents are in treating hypertension-associated target organ damage...
  75. ncbi Benazepril combined with either amlodipine or hydrochlorothiazide is more effective than monotherapy for blood pressure control and prevention of end-organ injury in hypertensive Dahl rats
    Ming Sheng Zhou
    Nephrology Section, VA Medical Center, Renal Division, Miller School of Medicine, and Vascular Biology Institute, University of Miami, Miami, Florida, USA
    J Cardiovasc Pharmacol 48:857-61. 2006
    ..Complementary mechanisms of action of agents from different antihypertensive classes appear to facilitate the greater benefit on BP and end-organ injury...
  76. ncbi Abnormal expression of ENaC and SGK1 mRNA induced by dietary sodium in Dahl salt-sensitively hypertensive rats
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Cell Biol Int 31:1288-91. 2007
    ....
  77. ncbi The antihypertensive effects of quercetin in a salt-sensitive model of hypertension
    I Mackraj
    Discipline of Human Physiology, School of Basic and Applied Medical Sciences, University of KwaZulu Natal, Durban, South Africa
    J Cardiovasc Pharmacol 51:239-45. 2008
    ..QUE did not differ significantly from controls with regards to aldosterone levels. QUE was effective in lowering blood pressure in this model of hypertension, probably because of a modulation of renal function...
  78. ncbi Action of thiazide on renal interstitial calcium
    Shaleka L Eley
    JLC Biomedical Biotechnology Research Institute, North Carolina Central University, Durham, North Carolina, USA
    Am J Hypertens 21:814-9. 2008
    ....
  79. pmc Exposure to maternal diabetes induces salt-sensitive hypertension and impairs renal function in adult rat offspring
    Touria Nehiri
    Institut National de la Sante et de la Recherche Medicale, Unite Mixte de Recherche S872, Centre de Recherche des Cordeliers, Paris, France
    Diabetes 57:2167-75. 2008
    ..The aim of the study was to assess, in the rat, long-term effects of in utero exposure to maternal diabetes on blood pressure and renal function in adulthood...
  80. ncbi Multiple blood pressure loci on rat chromosome 13 attenuate development of hypertension in the Dahl S hypertensive rat
    Carol Moreno
    Department of Physiology, Medical College of Wisconsin, Milwaukee, Wisconsin 53266, USA
    Physiol Genomics 31:228-35. 2007
    ..We conclude from these studies that there are four regions within chromosome 13 containing genes that interact epistatically and influence arterial pressure...
  81. ncbi Thiazolidinediones inhibit the progression of established hypertension in the Dahl salt-sensitive rat
    Charles W Bolten
    Discovery Research, Pfizer Corporation, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    Diab Vasc Dis Res 4:117-23. 2007
    ..These data suggest that it may be possible to find insulin-sensitising agents that have beneficial cardiovascular pharmacology with broad applications for disease prevention...
  82. ncbi Relief of chronic partial ureteral obstruction attenuates salt-sensitive hypertension in rats
    M Carlström
    Department of Medical Cell Biology, Division of Integrative Physiology, University of Uppsala, Uppsala, Sweden
    Acta Physiol (Oxf) 189:67-75. 2007
    ..In this study, the effects of ipsilateral and contralateral nephrectomy and ureterovesicostomy on blood pressure were studied in hydronephrotic animals...
  83. ncbi Beneficial effects of the combination of nifedipine and losartan in hypertensive Dahl salt-sensitive rats
    Hanna Tinel
    Product Related Research, Pharmacology, Pharma R and D Discovery Research, Bayer HealthCare AG, Wuppertal, Germany
    J Cardiovasc Pharmacol 50:75-82. 2007
    ..The antihypertensive and organ-protective effects of the combination of the angiotensin II type 1 receptor blocker losartan and the calcium channel blocker nifedipine were examined in Dahl salt-sensitive rats...
  84. ncbi A miso (Japanese soybean paste) diet conferred greater protection against hypertension than a sodium chloride diet in Dahl salt-sensitive rats
    Hiromitsu Watanabe
    Department of Experimental Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Hiroshima, Japan
    Hypertens Res 29:731-8. 2006
    ..3% NaCI was significantly increased from 8 weeks after treatment. Nephropathy was observed in both sexes of Dahl rats but not SD rats. These results show that blood pressure was not increased by the miso diet...
  85. ncbi Rat chromosome 19 transfer from SHR ameliorates hypertension, salt-sensitivity, cardiovascular and renal organ damage in salt-sensitive Dahl rats
    Norbert Wendt
    Institut fur Klinische Pharmakologie und Toxikologie, Charite Universitatsmedizin Berlin, Berlin, Germany
    J Hypertens 25:95-102. 2007
    ..In previous linkage studies, we identified quantitative trait loci on rat chromosome 19 (RNO19) linked to the SHR allele suggesting a protective effect against salt-induced hypertensive organ damage in SS...
  86. ncbi Interactions between oxidative stress and inflammation in salt-sensitive hypertension
    N Tian
    Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA
    Am J Physiol Heart Circ Physiol 293:H3388-95. 2007
    ..In conclusion, antioxidant treatment of high-Na Dahl S rats decreased renal inflammatory cytokines and chemokines, renal immune cells, NF-kappaB, and arterial pressure and improved renal function and damage...
  87. ncbi Novel mechanism and role of angiotensin II induced vascular endothelial injury in hypertensive diastolic heart failure
    Eiichiro Yamamoto
    Department of Pharmacology and Molecular Therapeutics, Kumamoto University Graduate School of Medical Sciences, 1 1 1 Honjyo, Kumamoto 860 8556, Japan
    Arterioscler Thromb Vasc Biol 27:2569-75. 2007
    ..We examined the molecular mechanism of angiotensin (AII)-induced vascular endothelial injury and its significance for hypertensive diastolic heart failure...
  88. pmc High perfusion pressure accelerates renal injury in salt-sensitive hypertension
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    J Am Soc Nephrol 19:1472-82. 2008
    ..We conclude that elevations of RPP contribute significantly to the fibrosis and epithelial-to-mesenchymal transition found in the early phases of hypertension in the salt-sensitive rat...
  89. ncbi Pregnancy prevents hypertensive remodeling and decreases myogenic reactivity in posterior cerebral arteries from Dahl salt-sensitive rats: a role in eclampsia?
    Annet M Aukes
    Department of Neurology, University of Vermont, 89 Beaumont Ave, Given C454, Burlington, VT 05405, USA
    Am J Physiol Heart Circ Physiol 292:H1071-6. 2007
    ..This effect may predispose the brain to autoregulatory breakthrough, hyperperfusion, and eclampsia when MAP is elevated...
  90. ncbi Enhanced monocyte adherence to thoracic aortae from rats with two forms of experimental hypertension
    T Asagami
    Department of Medicine, Stanford University School of Medicine, California, USA
    Am J Hypertens 12:890-3. 1999
    ..7 +/- 0.2 v 1.1 +/-0.1, P < .05). These results provide evidence that hypertension in Dahl-S and fructose-fed S-D rats was associated with changes in the endothelium that favor atherogenesis...
  91. ncbi Identification of salt-sensitive genes in the kidneys of Dahl rats
    Geoffrey K Lighthall
    Department of Physiology and Medicine, University of Maryland, Veterans Administration Medical Center, Baltimore, Maryland 21201, USA
    J Hypertens 22:1487-94. 2004
    ..We probed the kidneys of inbred Dahl SS/Jr and SR/Jr for anonymous and candidate genes whose expression was regulated by dietary sodium...
  92. ncbi Hypertension, sodium retention, calcium excretion and osteopenia in Dahl rats
    Jens Titze
    Department of Medicine IV, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    J Hypertens 22:803-10. 2004
    ..Salt-sensitive hypertension in the Dahl rat is associated with abnormalities in both calcium (Ca2+) and sodium (Na) homeostasis...
  93. ncbi Linkage of Na(+) and Ca(2+) balance: evidence that Na(+) retention preserves Ca(2+) balance and limits bone wasting
    Richard D Bukoski
    J Hypertens 22:683-5. 2004
  94. ncbi Flavonoid-induced reduction of ENaC expression in the kidney of Dahl salt-sensitive hypertensive rat
    Wataru Aoi
    Department of Molecular Cell Physiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 315:892-6. 2004
    ....
  95. ncbi Role of pressure in angiotensin II-induced renal injury: chronic servo-control of renal perfusion pressure in rats
    Takefumi Mori
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Hypertension 43:752-9. 2004
    ..We conclude that the preferential juxtamedullary injury found in Ang II hypertension is largely induced by pressure and is probably mediated through the TGF-beta and NF-kappaB pathway...
  96. pmc Effects of tempol on renal angiotensinogen production in Dahl salt-sensitive rats
    Hiroyuki Kobori
    Department of Physiology and Hypertension and Renal Center of Excellence, Tulane University Health Sciences Center, New Orleans, LA 70112 2699, USA
    Biochem Biophys Res Commun 315:746-50. 2004
    ..The evidence suggests that the enhanced intrarenal angiotensinogen in DS challenged with HS is associated with the augmented reactive oxygen species...
  97. ncbi Elevated BSC-1 and ROMK expression in Dahl salt-sensitive rat kidneys
    Kimberly M Hoagland
    Medical College of Wisconsin, Department of Physiology, Milwaukee, WI 53226, USA
    Hypertension 43:860-5. 2004
    ..BN13 rats. These results suggest that overexpression of ROMK and BSC-1 in the thick ascending limb combined with a deficiency in renal formation of 20-HETE may predispose Dahl S rats fed a high-salt diet to Na+ retention and hypertension...
  98. ncbi Membrane ion transport in erythrocytes of salt hypertensive Dahl rats and their F2 hybrids: the importance of cholesterol
    Martina Vokurkova
    Institute of Physiology, Academy of Sciences of the Czech Republic, Center for Experimental Research of Cardiovascular Diseases, Prague, Czech Republic
    Hypertens Res 26:397-404. 2003
    ..18 and 0.21, p<0.05). Our results support the idea that abnormal lipid metabolism and/or altered Na+,K(+)-ATPase function play an important role in the pathogenesis of salt hypertension in salt-sensitive Dahl rats...
  99. ncbi Effects of high salt intake on brain AT1 receptor densities in Dahl rats
    Jun Ming Wang
    Hypertension Unit, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa, Ontario, Canada K1Y 4W7
    Am J Physiol Heart Circ Physiol 285:H1949-55. 2003
    ....
  100. ncbi Aminoguanidine inhibits mitogen-activated protein kinase and improves cardiac performance and cardiovascular remodeling in failing hearts of salt-sensitive hypertensive rats
    Naohiko Kobayashi
    Department of Hypertension and Cardiorenal Medicine, Dokkyo University School of Medicine, Mibu, Tochigi, Japan
    J Hypertens 20:2475-85. 2002
    ..Thus, we evaluated whether aminoguanidine (AG), a selective iNOS inhibitor, protects against cardiac dysfunction and vascular remodeling in DS rats receiving a high-salt diet...
  101. ncbi Effects of L-carnosine on renal sympathetic nerve activity and DOCA-salt hypertension in rats
    Akira Niijima
    Niigata University School of Medicine, Asahimachidoori, Japan
    Auton Neurosci 97:99-102. 2002
    ....

Research Grants67

  1. NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2001
    ..This is particularly the case where dietary sodium chloride (salt) intake is high...
  2. NEURAL MECHANISMS OF LONG-TERM CARDIOVASCULAR CONTROL
    John Osborn; Fiscal Year: 2007
    ..Taken together, this integrative physiological approach will advance our understanding of the neural mechanisms for long-term control of arterial pressure and pathogenesis of neurogenic hypertension. [unreadable] [unreadable]..
  3. Long-Term Neural Determinants of Cardiovascular Diseases
    John Osborn; Fiscal Year: 2009
    ..abstract_text> ..
  4. Clinical Trial of Dietary Protein on Blood Pressure
    Jiang He; Fiscal Year: 2006
    ..Results from the proposed study may provide the scientific evidence for protein supplementation recommendations for the prevention and treatment of hypertension in the general population. ..
  5. Molecular Sensing of Sodium Homeostasis: Anandamide Role
    Donna Wang; Fiscal Year: 2009
    ....
  6. Sodium and Cardiovascular Disease in Patients with Chronic Kidney Disease
    Jiang He; Fiscal Year: 2010
    ....
  7. RENAL ANGIOTENSIN II RECEPTOR AND SODIUM INTAKE
    Donna Wang; Fiscal Year: 2007
    ..abstract_text> ..
  8. Genetic Epidemiology of Blood Pressure Intervention
    Jiang He; Fiscal Year: 2008
    ..In addition, identifying genes related to salt-sensitivity and potassium-sensitivity of BP should enable the discovery of new pharmaceutical treatment for hypertension. [unreadable] [unreadable] [unreadable]..
  9. Humoral Interactions in long-term blood pressure control
    VIRGINIA BROOKS; Fiscal Year: 2005
    ..abstract_text> ..
  10. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..Successful completion of the proposed work will expand the knowledge base on brain mechanisms controlling bodily fluid homeostasis. ..
  11. Oxidative Stress And Sympathetic Nerve Activity
    Vito Campese; Fiscal Year: 2006
    ..If our hypothesis were to be correct, administration of inhibitors of the renin-angiotensin system particularly if combined with antioxidants should result in better control of BP in these models. ..
  12. Chronic Alcohol Consumption Induces Tumor Angiogenesis
    Jian Wei Gu; Fiscal Year: 2006
    ..The new information will promote cancer prevention and treatment. ..
  13. Causal Models for CVD Use by Aspirin and Vitamin E in the Women's Health Study
    Nancy Cook; Fiscal Year: 2008
    ..The findings of reduced risk of CVD mortality, however, as well as effects by age, should be explored further to clarify the public health message. [unreadable] [unreadable] [unreadable]..
  14. NEUROPEPTIDES AND CARDIOVASCULAR REGULATION
    VIRGINIA BROOKS; Fiscal Year: 2002
    ....
  15. Renal Control of Blood Pressure in Early Diabetes
    Michael Brands; Fiscal Year: 2007
    ..whether increased SOD1 in transgenic mice protects against hypertension similar to tempol; d. the role of NADPH oxidase, by measuring p22 phox expression and the effect of apocynin. ..
  16. 8th World Congress for Microcirculation
    JULIAN LOMBARD; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  17. Renal 11b-Hydroxysteroid Dehydrogenases and Hypertension
    Mingyu Liang; Fiscal Year: 2008
    ..The results are expected to elucidate a novel aspect of the pathophysiology of salt- sensitive hypertension and to provide potential new targets for prevention and treatment of hypertension. ..
  18. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  19. Role of ANG II in Maintaining Vascular Relaxation in Dahl S Rats
    Julian H Lombard; Fiscal Year: 2010
    ..abstract_text> ..
  20. Intrarenal Augmentation of Angiotensinogen by Ang II
    Hiroyuki Kobori; Fiscal Year: 2010
    ..abstract_text> ..
  21. Gold standard methods for fluoride analysis
    ESPERANZA MARTINEZ MIER; Fiscal Year: 2003
    ..The proposed study will provide an opportunity to resolve discrepancies that currently make it difficult to compare the results of the many studies dealing with fluoride analyses. ..
  22. Development of Objective Methods for Fluorosis Diagnosis
    ESPERANZA MARTINEZ MIER; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  23. OBSERVATIONAL COHORT STUDY OF SODIUM, WEIGHT AND CVD
    Nancy Cook; Fiscal Year: 2003
    ..This cohort provides a unique resource to address the impact in a normotensive population of salt restriction and weight change on subsequent cardiovascular events. ..
  24. RENAL POTASSIUM TRANSPORT IN PHYSIOLOGY AND DISEASES
    Chou Long Huang; Fiscal Year: 2005
    ..The biochemical studies will be correlated with electrophysiological recording of channel activity. ..
  25. Human Telomere Genetics
    Abraham Aviv; Fiscal Year: 2008
    ..Results will serve to define genes as determinants of telomere length. Such information would lead to new diagnostic and therapeutic approaches to treat age-related diseases. ..
  26. WEIGHT LOSS MAINTENANCE TRIAL
    Lawrence Appel; Fiscal Year: 2007
    ..The purpose of this proposal is to develop and test two such interventions, which, if effective, should complement ongoing efforts to stem the obesity epidemic and ultimately prevent obesity-related CVD. ..
  27. Hepcidin and the pathogenesis of anemia in older adults.
    Richard D Semba; Fiscal Year: 2010
    ..This study should provide new insight into the epidemiology and biological mechanisms of anemia among older adults and help identify strategies aimed at the prevention and treatment of anemia. ..
  28. NPY Feeding Circuits during Development
    Kevin Grove; Fiscal Year: 2007
    ..Understanding of the normal and abnormal development of this circuitry is critical to determining the physiological mechanisms that underlie adult obesity and identify a critical period for possible intervention. ..
  29. PREDOCTORAL TRAINING PROGRAM IN THE NEUROSCIENCES
    Robert Contreras; Fiscal Year: 2007
    ....
  30. Neural Plasticity and Sensitization of Salt Appetite
    ILENE BERNSTEIN; Fiscal Year: 2007
    ..abstract_text> ..
  31. PHYSIOLOGY OF THE PROLACTIN RELEASING PEPTIDES
    Willis K Samson; Fiscal Year: 2010
    ..Additionally, these studies will provide further insight into the coordinated hormonal and autonomic responses to stress. ..
  32. Predictors of Nephropathy in Type 2 Diabetes
    Julie Lin; Fiscal Year: 2008
    ..D., Ph.D., a leading investigator in the field of nutritional epidemiology. This project proposal will provide the foundation for the candidate's future career as an independent and successful clinical scientist in renal research. ..
  33. IN VIVO PATHOGENESIS OF HELICOBACTER PYLORI
    James Fox; Fiscal Year: 2009
    ..pylori pathogenesis and specifically evaluate the role of regulatory T cells in limiting H. pylori-induced gastric pathology. ..
  34. CEREBAL ARTERIAL ADVENTITIA AND VASOSPASM
    ZVONIMIR KATUSIC; Fiscal Year: 2001
    ..Our studies will also expand the knowledge base concerning the vascular biology of adventitia, and its role as a target for transfer and expression of therapeutically beneficial recombinant proteins. ..
  35. Advances in Renal Research: Human Diseases of Protein Processing
    David Ellison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  36. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  37. Tool to Define the Antiproliferative Effects of Agmatine
    Joseph Satriano; Fiscal Year: 2006
    ..These pathways will have particular application to diabetes and IRI in kidney, models we plan to pursue. [unreadable] [unreadable]..
  38. ANGIOTENSIN TYPE IA RECEPTOR IN PRESSURE NATRIURESIS
    AMY MANGRUM; Fiscal Year: 2004
    ..The Nephrology Divisions will ensure protected time for her research and didactic work. ..
  39. CNS AND SALT APPETITE
    DOUGLAS FITTS; Fiscal Year: 2004
    ..The results will have implications for the central control of blood pressure and endocrine secretions as well as behavior during various challenges to body hydration. ..
  40. A new method to measure taste bud function
    Stephen Roper; Fiscal Year: 2004
    ..If these cells turn out to be mechanoreceptors, the results may explain how taste buds detect food texture. This will greatly further our understanding of food selection and diet. ..
  41. GENOMIC & NONGENOMIC EFFECTS OF STEROIDS ON SALT INTAKE
    Randall Sakai; Fiscal Year: 2004
    ....
  42. DIETARY SALT AND THE MICROVASCULAR ENDOTHELIUM
    MATTHEW BOEGEHOLD; Fiscal Year: 2003
    ..This project will provide important insight into the mechanisms by which dietary salt can alter microvascular function in normotensive individuals. ..
  43. ALCOHOL OUTLETS, BROKEN WINDOWS, GONORRHEA AND HIV RISK
    Deborah Cohen; Fiscal Year: 2003
    ..The findings will inform future HIV prevention interventions and provide guidance to CBOs as to whether control of alcohol outlets and neighborhood development may enhance the prevention of HIV transmission. ..
  44. ANGII NEURAL INTERACTIONS IN CARDIOVASCULAR CONTROL
    JOHN COLLISTER; Fiscal Year: 2002
    ..Upon completion, Dr. Collister will have fully developed into an independent investigator. ..
  45. ANG II AND AVP ISORECEPTORS IN BLOOD PRESSURE
    Nelson Ruiz Opazo; Fiscal Year: 2002
    ....
  46. RENAL MEDULLARY NITRIC OXIDE AND BLOOD PRESSURE
    David Mattson; Fiscal Year: 2001
    ....
  47. Withdrawal of statins and vascular dysfunction
    LUIGI CUBEDDU; Fiscal Year: 2004
    ..Our study may provide the basis for preventive and corrective interventions to millions of people that are under statin treatment. ..
  48. FOREBRAIN AND HINDBRAIN MECHANISMS OF SALT APPETITE
    ROBERT THUNHORST; Fiscal Year: 2005
    ....
  49. Cardiovascular Effects of lyengar Yoga
    Raymond Townsend; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  50. Effect of Dietary Protein Source on Calcium Metabolism
    Deborah Sellmeyer; Fiscal Year: 2006
    ..Eventually our findings could have substantial public health implications and provide a widely available and low risk means to help prevent osteoporosis. ..
  51. DEVELOPING AND IMPROVING INSTITUTIONAL ANIMAL RESOURCES
    James Fox; Fiscal Year: 2006
    ....
  52. Vascular Protective Role of Endothelin B Receptors
    RAOUF KHALIL; Fiscal Year: 2006
    ..abstract_text> ..
  53. Diet and Genetic Risks for Prostate Cancer
    Marian Neuhouser; Fiscal Year: 2005
    ..To date, there are 718 confirmed cases of primary prostatic carcinoma. This proposed study will provide important information about prostate cancer etiology and suggest new strategies for prevention and control. ..
  54. Role of Caspase-9 in Heart
    Peter Kang; Fiscal Year: 2005
    ..Thus, the cardiac specific knockout of caspase-9 using Cre-loxP technology allows us to examine the tissue-specific role of capase-9 in adult animal. ..
  55. Robotics Extraction System/HPLC for Shared Resource Lab
    Mark Chappell; Fiscal Year: 2005
    ..abstract_text> ..
  56. ADJUNCT VITAMIN A THERAPY FOR TUBERCULOSIS AND HIV/AIDS
    Richard Semba; Fiscal Year: 2005
    ....
  57. Away From Home and Out of School
    Deborah A Cohen; Fiscal Year: 2010
    ..The findings will be useful to inform future community and population level interventions to promote healthy eating, active living, and obesity control. ..
  58. GIS, ALCOHOL MARKETING, AND ALCOHOL-RELATED OUTCOMES
    Deborah Cohen; Fiscal Year: 2006
    ..Because alcohol marketing is already regulated, if certain marketing techniques are disproportionately associated with alcohol consumption and alcohol-related mortality, the findings can be used to inform public policy. ..
  59. USE OF ANTIOXIDANT SUPPLEMENTS AND OXIDATIVE DNA DAMAGE
    Marian Neuhouser; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  60. Agmatine Mediated Arrest of Proliferation
    Joseph Satriano; Fiscal Year: 2003
    ..UCSD has established itself as a leading academic institution and thus provides an excellent environment for the exchange of ideas and techniques essential for the growth of the PI's career. ..
  61. Postprandial glycemic response to 4-week low and high glycemic load diets
    Marian Neuhouser; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  62. Biomarkers in the progression of nephropathy in type 2DM
    Julie Lin; Fiscal Year: 2008
    ..Data on how these modifiable biomarkers are related to kidney function decline could have an important and beneficial impact on treatment and monitoring of nephropathy in type 2 diabetes in the near future. [unreadable] [unreadable]..
  63. Oxidative Stress and the Pathogenesis of Sarcopenia and Disability in Older Women
    Richard Semba; Fiscal Year: 2008
    ..AGEs are a potentially modifiable risk factor, as circulating AGEs can be lowered by dietary modification and by pharmacological intervention. ..
  64. VITAMIN A SUPPLEMENTATION FOR HIV INFECTED CHILDREN
    Richard Semba; Fiscal Year: 2002
    ....