sodium chloride

Summary

Summary: A ubiquitous sodium salt that is commonly used to season food. It plays an important biological role in maintaining the osmotic tension of blood and tissues.

Top Publications

  1. ncbi Monitoring the expression profiles of 7000 Arabidopsis genes under drought, cold and high-salinity stresses using a full-length cDNA microarray
    Motoaki Seki
    Plant Mutation Exploration Team, Plant Functional Genomics Research Group, RIKEN Genomic Sciences Center, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    Plant J 31:279-92. 2002
  2. ncbi Mechanisms of salinity tolerance
    Rana Munns
    CSIRO Plant Industry, Canberra, ACT, Australia
    Annu Rev Plant Biol 59:651-81. 2008
  3. pmc Salt and drought stress signal transduction in plants
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Plant Biol 53:247-73. 2002
  4. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
  5. ncbi Cold, salinity and drought stresses: an overview
    Shilpi Mahajan
    Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 444:139-58. 2005
  6. pmc Cell signaling during cold, drought, and salt stress
    Liming Xiong
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Plant Cell 14:S165-83. 2002
  7. ncbi Plant salt tolerance
    J K Zhu
    Dept Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Trends Plant Sci 6:66-71. 2001
  8. pmc Overexpressing a NAM, ATAF, and CUC (NAC) transcription factor enhances drought resistance and salt tolerance in rice
    Honghong Hu
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Wuhan 430070, China
    Proc Natl Acad Sci U S A 103:12987-92. 2006
  9. pmc Monitoring expression profiles of rice genes under cold, drought, and high-salinity stresses and abscisic acid application using cDNA microarray and RNA gel-blot analyses
    M Ashiq Rabbani
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Physiol 133:1755-67. 2003
  10. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003

Detail Information

Publications370 found, 100 shown here

  1. ncbi Monitoring the expression profiles of 7000 Arabidopsis genes under drought, cold and high-salinity stresses using a full-length cDNA microarray
    Motoaki Seki
    Plant Mutation Exploration Team, Plant Functional Genomics Research Group, RIKEN Genomic Sciences Center, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    Plant J 31:279-92. 2002
    ....
  2. ncbi Mechanisms of salinity tolerance
    Rana Munns
    CSIRO Plant Industry, Canberra, ACT, Australia
    Annu Rev Plant Biol 59:651-81. 2008
    ..Molecular genetics and functional genomics provide a new opportunity to synthesize molecular and physiological knowledge to improve the salinity tolerance of plants relevant to food production and environmental sustainability...
  3. pmc Salt and drought stress signal transduction in plants
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Plant Biol 53:247-73. 2002
    ....
  4. pmc Transcriptome changes for Arabidopsis in response to salt, osmotic, and cold stress
    Joel A Kreps
    Torrey Mesa Research Institute, Syngenta, 3115 Merryfield Row, San Diego, California 92121, USA
    Plant Physiol 130:2129-41. 2002
    ..Although these results identify hundreds of potentially important transcriptome changes, the biochemical functions of many stress-regulated genes remain unknown...
  5. ncbi Cold, salinity and drought stresses: an overview
    Shilpi Mahajan
    Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi 110067, India
    Arch Biochem Biophys 444:139-58. 2005
    ..In each of these stresses we have tried to address the issues, which significantly affect the gene expression in relation to plant physiology...
  6. pmc Cell signaling during cold, drought, and salt stress
    Liming Xiong
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Plant Cell 14:S165-83. 2002
  7. ncbi Plant salt tolerance
    J K Zhu
    Dept Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Trends Plant Sci 6:66-71. 2001
    ....
  8. pmc Overexpressing a NAM, ATAF, and CUC (NAC) transcription factor enhances drought resistance and salt tolerance in rice
    Honghong Hu
    National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research, Wuhan 430070, China
    Proc Natl Acad Sci U S A 103:12987-92. 2006
    ..DNA chip analysis revealed that a large number of stress-related genes were up-regulated in the SNAC1-overexpressing rice plants. Our data suggest that SNAC1 holds promising utility in improving drought and salinity tolerance in rice...
  9. pmc Monitoring expression profiles of rice genes under cold, drought, and high-salinity stresses and abscisic acid application using cDNA microarray and RNA gel-blot analyses
    M Ashiq Rabbani
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant Physiol 133:1755-67. 2003
    ..Transcriptome analysis revealed novel stress-inducible genes, suggesting some differences between Arabidopsis and rice in their response to stress...
  10. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
    ..OsDREB1A is potentially useful for producing transgenic monocots that are tolerant to drought, high-salt, and/or cold stresses...
  11. ncbi Salt tolerance conferred by overexpression of a vacuolar Na+/H+ antiport in Arabidopsis
    M P Apse
    Department of Botany, University of Toronto, 25 Willcocks Street, Toronto, Ontario M5S 3B2, Canada
    Science 285:1256-8. 1999
    ..in Arabidopsis plants promotes sustained growth and development in soil watered with up to 200 millimolar sodium chloride. This salinity tolerance was correlated with higher-than-normal levels of AtNHX1 transcripts, protein, and ..
  12. ncbi Plant responses to drought, salinity and extreme temperatures: towards genetic engineering for stress tolerance
    Wangxia Wang
    The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, and the Otto Warburg Center for Agricultural Biotechnology, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel
    Planta 218:1-14. 2003
    ..The review examines the following aspects: regulatory controls, metabolite engineering, ion transport, antioxidants and detoxification, late embryogenesis abundant (LEA) and heat-shock proteins...
  13. ncbi Functional analysis of a NAC-type transcription factor OsNAC6 involved in abiotic and biotic stress-responsive gene expression in rice
    Kazuo Nakashima
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 51:617-30. 2007
    ..We conclude that OsNAC6 may serve as a useful biotechnological tool for the improvement of stress tolerance in various kinds of plants...
  14. ncbi Methods and concepts in quantifying resistance to drought, salt and freezing, abiotic stresses that affect plant water status
    Paul E Verslues
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Plant J 45:523-39. 2006
    ....
  15. pmc The Arabidopsis thaliana salt tolerance gene SOS1 encodes a putative Na+/H+ antiporter
    H Shi
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Proc Natl Acad Sci U S A 97:6896-901. 2000
    ..SOS1 gene expression in plants is up-regulated in response to NaCl stress. This up-regulation is abated in sos3 or sos2 mutant plants, suggesting that it is controlled by the SOS3/SOS2 regulatory pathway...
  16. ncbi Genes and salt tolerance: bringing them together
    Rana Munns
    CSIRO Plant Industry, GPO Box 1600, Canberra ACT 2601, Australia
    New Phytol 167:645-63. 2005
    ..Suggestions are made to increase the value of molecular studies in identifying genes that are important for salinity tolerance...
  17. ncbi AtNAC2, a transcription factor downstream of ethylene and auxin signaling pathways, is involved in salt stress response and lateral root development
    Xin Jian He
    National Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant J 44:903-16. 2005
    ..AtNAC2 also promoted or inhibited downstream gene expressions. These results indicate that AtNAC2 may be a transcription factor incorporating the environmental and endogenous stimuli into the process of plant lateral root development...
  18. ncbi Stress-induced changes in the Arabidopsis thaliana transcriptome analyzed using whole-genome tiling arrays
    Georg Zeller
    Department of Molecular Biology, Max Planck Institute for Developmental Biology, 72076 Tubingen, Germany
    Plant J 58:1068-82. 2009
    ....
  19. pmc Overexpression of AtMYB44 enhances stomatal closure to confer abiotic stress tolerance in transgenic Arabidopsis
    Choonkyun Jung
    Department of Agricultural Biotechnology, Seoul National University, Seoul 151 921, Korea
    Plant Physiol 146:623-35. 2008
    ..Therefore, enhanced abiotic stress tolerance of transgenic Arabidopsis overexpressing AtMYB44 was conferred by reduced expression of genes encoding PP2Cs, which have been described as negative regulators of ABA signaling...
  20. ncbi A rice quantitative trait locus for salt tolerance encodes a sodium transporter
    Zhong Hai Ren
    National Key Laboratory of Plant Molecular Genetics, Shanghai Institute of Plant Physiology and Ecology, Shanghai Institute for Biological Sciences, The Chinese Academy of Sciences, 300 Fenglin Road, Shanghai 200032, China
    Nat Genet 37:1141-6. 2005
    ..Physiological analysis suggested that SKC1 is involved in regulating K(+)/Na(+) homeostasis under salt stress, providing a potential tool for improving salt tolerance in crops...
  21. ncbi Salt tolerance and salinity effects on plants: a review
    Asish Kumar Parida
    National Institute for Plant Biodiversity Conservation and Research, Nayapalli, Bhubaneswar 751015, Orissa, India
    Ecotoxicol Environ Saf 60:324-49. 2005
    ..This review may help in interdisciplinary studies to assess the ecological significance of salt stress...
  22. ncbi Arabidopsis transcriptome analysis under drought, cold, high-salinity and ABA treatment conditions using a tiling array
    Akihiro Matsui
    Plant Genomic Network Research Team, Plant Functional Genomics Research Group, RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, 230 0045 Japan
    Plant Cell Physiol 49:1135-49. 2008
    ....
  23. ncbi Stress-induced DNA methylation changes and their heritability in asexual dandelions
    Koen J F Verhoeven
    Department of Terrestrial Ecology, Netherlands Institute of Ecology NIOO KNAW, Heteren, The Netherlands
    New Phytol 185:1108-18. 2010
    ..This highlights the potential of epigenetic inheritance to play an independent role in evolutionary processes, which is superimposed on the system of genetic inheritance...
  24. pmc Comparative genomics in salt tolerance between Arabidopsis and aRabidopsis-related halophyte salt cress using Arabidopsis microarray
    Teruaki Taji
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, Tsukuba, Ibaraki 305 0074, Japan
    Plant Physiol 135:1697-709. 2004
    ..Stress tolerance of salt cress may be due to constitutive overexpression of many genes that function in stress tolerance and that are stress inducible in Arabidopsis...
  25. pmc The zinc-finger protein Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis
    Sholpan Davletova
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, 89557, USA
    Plant Physiol 139:847-56. 2005
    ..Our results suggest that Zat12 plays a central role in reactive oxygen and abiotic stress signaling in Arabidopsis...
  26. ncbi Mechanisms of high salinity tolerance in plants
    Narendra Tuteja
    Plant Molecular Biology, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Marg, New Delhi, India
    Methods Enzymol 428:419-38. 2007
    ..The cross-tolerance between stresses is also mentioned...
  27. ncbi Salinity stress adaptation competence in the extremophile Thellungiella halophila in comparison with its relative Arabidopsis thaliana
    Qingqiu Gong
    Department of Plant Biology, University of Illinois at Urbana Champaign, 61801, USA
    Plant J 44:826-39. 2005
    ..At 150 mm NaCl, Thellungiella maintained unimpeded growth. Transcript intensity analyses and metabolite profiles supported the microarray results, pointing towards a stress-anticipatory preparedness in Thellungiella...
  28. pmc Early effects of salinity on water transport in Arabidopsis roots. Molecular and cellular features of aquaporin expression
    Yann Boursiac
    Biochimie et Physiologie Moleculaire des Plantes, Agro Montpellier Centre National de la Recherche Scientifique Institut National de la Recheche Agonomique Université Montpellier 2, Unité Mixte de Recherche 5004, France
    Plant Physiol 139:790-805. 2005
    ..These changes include a coordinated transcriptional down-regulation and subcellular relocalization of both PIPs and TIPs. These mechanisms may act in concert to regulate root water transport, mostly in the long term (> or =6 h)...
  29. ncbi Characterization of transcription factor gene SNAC2 conferring cold and salt tolerance in rice
    Honghong Hu
    National Center of Plant Gene Research Wuhan, National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China
    Plant Mol Biol 67:169-81. 2008
    ..These data suggest SNAC2 is a novel stress responsive NAC transcription factor that possesses potential utility in improving stress tolerance of rice...
  30. ncbi Potassium transport and plant salt tolerance
    Sergey Shabala
    School of Agricultural Science, University of Tasmania, Private Bag 54, Hobart, Tasmania 7001, Australia
    Physiol Plant 133:651-69. 2008
    ..The molecular identity of 'salt tolerance' genes is analysed, and prospects for future research and breeding are examined...
  31. pmc The putative plasma membrane Na(+)/H(+) antiporter SOS1 controls long-distance Na(+) transport in plants
    Huazhong Shi
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Plant Cell 14:465-77. 2002
    ..We present a model in which SOS1 functions in retrieving Na(+) from the xylem stream under severe salt stress, whereas under mild salt stress it may function in loading Na(+) into the xylem...
  32. ncbi Salinity tolerance in halophytes
    Timothy J Flowers
    School of Life Sciences, University of Sussex, Falmer, Brighton, Sussex, BN1 9QG, UK
    New Phytol 179:945-63. 2008
    ....
  33. ncbi Soybean WRKY-type transcription factor genes, GmWRKY13, GmWRKY21, and GmWRKY54, confer differential tolerance to abiotic stresses in transgenic Arabidopsis plants
    Qi Yun Zhou
    Plant Gene Research Centre, The National Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Biotechnol J 6:486-503. 2008
    ..These results indicate that the three GmWRKY genes play differential roles in abiotic stress tolerance, and that GmWRKY13 may function in both lateral root development and the abiotic stress response...
  34. ncbi Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor
    M Kasuga
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Ministry of Agriculture, Forestry and Fisheries, Tsukuba, Ibaraki
    Nat Biotechnol 17:287-91. 1999
    ....
  35. ncbi Improving crop salt tolerance
    T J Flowers
    School of Biological Sciences, University of Sussex, Falmer, Brighton, Sussex BN1 9QG, UK and School of Plant Biology, 35 Stirling Highway, Crawley, Western Australia 6009, Australia
    J Exp Bot 55:307-19. 2004
    ..After ten years of research using transgenic plants to alter salt tolerance, the value of this approach has yet to be established in the field...
  36. ncbi Regulation by arbuscular mycorrhizae of the integrated physiological response to salinity in plants: new challenges in physiological and molecular studies
    Juan Manuel Ruiz-Lozano
    Dpto Microbiología del Suelo y Sistemas Simbióticos, Estación Experimental del Zaidín CSIC, Profesor Albareda 1, 18008, Granada, Spain
    J Exp Bot 63:4033-44. 2012
    ..This review summarizes current knowledge about the effects of AM symbiosis on these physiological mechanisms, emphasizing new perspectives and challenges in physiological and molecular studies on salt-stress alleviation by AM symbiosis...
  37. ncbi Receptor-like kinase OsSIK1 improves drought and salt stress tolerance in rice (Oryza sativa) plants
    Shou Qiang Ouyang
    Plant Gene Research Center, National Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant J 62:316-29. 2010
    ..These results indicate that OsSIK1 plays important roles in salt and drought stress tolerance in rice, through the activation of the antioxidative system...
  38. pmc The progeny of Arabidopsis thaliana plants exposed to salt exhibit changes in DNA methylation, histone modifications and gene expression
    Andriy Bilichak
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Alberta, Canada
    PLoS ONE 7:e30515. 2012
    ..of methylation patterns in the progeny of Arabidopsis thaliana (Arabidopsis) plants exposed to 25 and 75 mM sodium chloride. We found that the majority of gene promoters exhibiting changes in methylation were hypermethylated, and ..
  39. pmc Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions
    Y Uno
    Biological Resources Division, Japan International Research Center for Agricultural Science JIRCAS, Ministry of Agriculture, Forestry, and Fisheries, Ohwashi 1 2, Tsukuba, Ibaraki 305 8686, Japan
    Proc Natl Acad Sci U S A 97:11632-7. 2000
    ..Using cultured Arabidopsis cells, we demonstrated that a specific ABA-activated protein kinase of 42-kDa phosphorylated conserved N-terminal regions in the AREB proteins...
  40. ncbi The role of root apoplastic transport barriers in salt tolerance of rice (Oryza sativa L.)
    Pannaga Krishnamurthy
    National Centre for Biological Sciences, TIFR, Bangalore 560065, India
    Planta 230:119-34. 2009
    ..Enhanced barriers were detected after several days of moderate stress. Overall, more extensive apoplastic barriers in roots correlated with reduced Na+ uptake and enhanced survival when challenged with high salinity...
  41. ncbi High-level overexpression of the Arabidopsis HsfA2 gene confers not only increased themotolerance but also salt/osmotic stress tolerance and enhanced callus growth
    Daisuke Ogawa
    Division of Functional Genomics, Advanced Science Research Center, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    J Exp Bot 58:3373-83. 2007
    ..These observations suggest that HsfA2 plays, in addition to its role in stress tolerance, an important role in cell proliferation...
  42. pmc Disease resistance and abiotic stress tolerance in rice are inversely modulated by an abscisic acid-inducible mitogen-activated protein kinase
    Lizhong Xiong
    Department of Plant Pathology and Program in Cell and Molecular Biology, University of Arkansas, Fayetteville, Arkansas 72701, USA
    Plant Cell 15:745-59. 2003
    ..These results strongly suggest that OsMAPK5 can positively regulate drought, salt, and cold tolerance and negatively modulate PR gene expression and broad-spectrum disease resistance...
  43. ncbi Isolation and molecular characterization of the Triticum aestivum L. ethylene-responsive factor 1 (TaERF1) that increases multiple stress tolerance
    Zhao Shi Xu
    National Key Facility of Crop Gene Resources and Genetic Improvement, Key Laboratory of Crop Genetics and Breeding, Ministry of Agriculture, Institute of Crop Science, Chinese Academy of Agriculture Sciences, Beijing 100081, PR China
    Plant Mol Biol 65:719-32. 2007
    ..These results suggested that the TaERF1 gene encodes a GCC-box and CRT/DRE element binding factor that might be involved in multiple stress signal transduction pathways...
  44. pmc The calcium sensor calcineurin B-like 9 modulates abscisic acid sensitivity and biosynthesis in Arabidopsis
    Girdhar K Pandey
    Department of Plant and Microbial Biology, University of California, Berkeley 94720, USA
    Plant Cell 16:1912-24. 2004
    ..This study has identified a calcium sensor as a common element in the ABA signaling and stress-induced ABA biosynthesis pathways...
  45. pmc Enhancing Arabidopsis salt and drought stress tolerance by chemical priming for its abscisic acid responses
    Gabor Jakab
    Institute of Botany, Biochemistry, University of Neuchatel, Switzerland
    Plant Physiol 139:267-74. 2005
    ..Here, we show a possibility to increase plant tolerance for these abiotic stresses through effective priming of the preexisting defense pathways without resorting to genetic alterations...
  46. ncbi The Arabidopsis basic leucine zipper transcription factor AtbZIP24 regulates complex transcriptional networks involved in abiotic stress resistance
    Oksoon Yang
    Department of Biochemistry and Physiology of Plants, Faculty of Biology, Bielefeld University, Bielefeld, Germany
    Gene 436:45-55. 2009
    ..It is concluded that AtbZIP24 is an important regulator of salt stress response in plants. The modification of transcriptional control by regulatory transcription factors provides a useful strategy for improving salt tolerance in plants...
  47. ncbi Overexpression of a plasma membrane Na+/H+ antiporter gene improves salt tolerance in Arabidopsis thaliana
    Huazhong Shi
    Department of Plant Sciences, University of Arizona, Tucson, AZ 85721, USA
    Nat Biotechnol 21:81-5. 2003
    ..These results show that improved salt tolerance could be achieved by limiting Na+ accumulation in plant cells...
  48. ncbi Comparative proteomic analysis of NaCl stress-responsive proteins in Arabidopsis roots
    Yuanqing Jiang
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    J Exp Bot 58:3591-607. 2007
    ....
  49. ncbi Transcriptome analysis reveals salt-stress-regulated biological processes and key pathways in roots of cotton (Gossypium hirsutum L.)
    Dongxia Yao
    State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, PR China
    Genomics 98:47-55. 2011
    ..Our transcriptome analysis might provide some useful insights into salt-mediated signal transduction pathways in cotton and offer a number of candidate genes as potential markers of tolerance to salt stress...
  50. ncbi Sodium chloride vs. sodium bicarbonate for the prevention of contrast medium-induced nephropathy: a randomized controlled trial
    Theresia Klima
    Department of Nephrology, University Hospital Basel, Basel, Switzerland
    Eur Heart J 33:2071-9. 2012
    The most effective regimen for the prevention of contrast-induced nephropathy (CIN) remains uncertain. Our purpose was to compare two regimens of sodium bicarbonate with 24 h sodium chloride 0.9% infusion in the prevention of CIN.
  51. pmc Overexpression of an R1R2R3 MYB gene, OsMYB3R-2, increases tolerance to freezing, drought, and salt stress in transgenic Arabidopsis
    Xiaoyan Dai
    Research Center for Molecular and Developmental Biology, Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
    Plant Physiol 143:1739-51. 2007
    ..These results suggest that OsMYB3R-2 acts as a master switch in stress tolerance...
  52. ncbi Sorghum bicolor's transcriptome response to dehydration, high salinity and ABA
    Christina D Buchanan
    Institute for Plant Genomics and Biotechnology, Texas A and M University, College Station, TX, 77843, USA
    Plant Mol Biol 58:699-720. 2005
    ..Overall, this study provides a foundation of information on sorghum's osmotic stress responsive gene complement that will accelerate follow up biochemical, QTL and comparative studies...
  53. ncbi Hydrogen-rich saline reduces lung injury induced by intestinal ischemia/reperfusion in rats
    Yan Fei Mao
    Department of Surgical Intensive Care Unit, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, PR China
    Biochem Biophys Res Commun 381:602-5. 2009
    ..In this study we investigated the effects of hydrogen-rich saline on the prevention of lung injury induced by intestinal ischemia/reperfusion (I/R) in rats...
  54. ncbi Regulation of vacuolar Na+/H+ exchange in Arabidopsis thaliana by the salt-overly-sensitive (SOS) pathway
    Quan Sheng Qiu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 279:207-15. 2004
    ....
  55. pmc Transgenerational adaptation of Arabidopsis to stress requires DNA methylation and the function of Dicer-like proteins
    Alex Boyko
    Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada
    PLoS ONE 5:e9514. 2010
    ..Our results are consistent with the hypothesis that stress-induced transgenerational responses in Arabidopsis depend on altered DNA methylation and smRNA silencing pathways...
  56. ncbi Bacterial osmoadaptation: the role of osmolytes in bacterial stress and virulence
    Roy D Sleator
    Department of Microbiology and National Food Biotechnology Centre, University College Cork, Cork, Ireland
    FEMS Microbiol Rev 26:49-71. 2002
    ..Finally, we examine the current knowledge on the role of these osmostress responsive systems in contributing to the virulence potential of a number of pathogenic bacteria...
  57. pmc Characterization of OsbZIP23 as a key player of the basic leucine zipper transcription factor family for conferring abscisic acid sensitivity and salinity and drought tolerance in rice
    Yong Xiang
    National Center of Plant Gene Research, National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan 430070, China
    Plant Physiol 148:1938-52. 2008
    ..We propose that OsbZIP23 is a major player of the bZIP family in rice for conferring ABA-dependent drought and salinity tolerance and has high potential usefulness in genetic improvement of stress tolerance...
  58. ncbi Comparative proteomic analysis of differentially expressed proteins in shoots of Salicornia europaea under different salinity
    Xuchu Wang
    Research Center for Molecular and Developmental Biology, Key Laboratory of Photosynthesis and Environmental Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, PR China
    J Proteome Res 8:3331-45. 2009
    ..europaea salt tolerance mechanism as a dynamic network. Finally, based on our proteomic results, we brought forward a possible schematic representation of mechanism associated with the systematic salt tolerance phenotype in S. europaea...
  59. pmc Transcriptional profiling implicates novel interactions between abiotic stress and hormonal responses in Thellungiella, a close relative of Arabidopsis
    Chui E Wong
    Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1
    Plant Physiol 140:1437-50. 2006
    ..Taken together, our results provide useful starting points for more in-depth analyses of Thellungiella's extreme stress tolerance...
  60. pmc Overexpression of a plasma membrane aquaporin in transgenic tobacco improves plant vigor under favorable growth conditions but not under drought or salt stress
    Refael Aharon
    Department of Plant Sciences, The Weizmann Institute of Science, Rehovot 76100, Israel
    Plant Cell 15:439-47. 2003
    ..By contrast, enhanced symplastic water transport via plasma membrane aquaporins may not have any beneficial effect under salt stress, and it has a deleterious effect during drought stress...
  61. ncbi Cellular response to hyperosmotic stresses
    Maurice B Burg
    National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892 1603, USA
    Physiol Rev 87:1441-74. 2007
    ....
  62. ncbi Approaches to increasing the salt tolerance of wheat and other cereals
    Rana Munns
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT, Australia
    J Exp Bot 57:1025-43. 2006
    ..Screening methods for these traits are discussed in relation to their use in breeding, particularly with respect to wheat. Precise phenotyping is the key to finding and introducing new genes for salt tolerance into crop plants...
  63. pmc TaSnRK2.4, an SNF1-type serine/threonine protein kinase of wheat (Triticum aestivum L.), confers enhanced multistress tolerance in Arabidopsis
    Xinguo Mao
    The National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China
    J Exp Bot 61:683-96. 2010
    ..4 could be utilized in transgenic breeding to improve abiotic stresses in crops...
  64. pmc Upgrading root physiology for stress tolerance by ectomycorrhizas: insights from metabolite and transcriptional profiling into reprogramming for stress anticipation
    Zhi Bin Luo
    College of Life Sciences, Northwest Agriculture and Forestry University, Yangling, Shaanxi 712100, People s Republic of China
    Plant Physiol 151:1902-17. 2009
    ..In conclusion, EMs activated stress-related genes and signaling pathways, apparently leading to priming of pathways conferring abiotic stress tolerance...
  65. pmc Photosynthesis under drought and salt stress: regulation mechanisms from whole plant to cell
    M M Chaves
    Instituto Superior de Agronomia, Technical University of Lisbon, Lisbon, Portugal
    Ann Bot 103:551-60. 2009
    ..Photosynthesis, together with cell growth, is among the primary processes to be affected by water or salt stress...
  66. ncbi Physiological mechanisms underlying OsNAC5-dependent tolerance of rice plants to abiotic stress
    Shi Yong Song
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, The Chinese Academy of Sciences, Beijing, 100093, People s Republic of China
    Planta 234:331-45. 2011
    ..These findings highlight the important role of OsNAC5 played in the tolerance of rice plants to abiotic stress by regulating downstream targets associated with accumulation of compatible solutes, Na(+) ions, H(2)O(2) and malondialdehyde...
  67. ncbi Sodium bicarbonate vs sodium chloride for the prevention of contrast medium-induced nephropathy in patients undergoing coronary angiography: a randomized trial
    Somjot S Brar
    Center for Interventional Vascular Therapy, Columbia University Medical Center, 161 Fort Washington Ave, Fifth Floor, New York, NY 10032, USA
    JAMA 300:1038-46. 2008
    ....
  68. ncbi Plasticity of chemotaxis revealed by paired presentation of a chemoattractant and starvation in the nematode Caenorhabditis elegans
    S Saeki
    Molecular Genetics Research Laboratory and Department of Biophysics and Biochemistry, The University of Tokyo, Bunkyo-ku, Tokyo 113-0033, Japan
    J Exp Biol 204:1757-64. 2001
    ..Using this assay, we have isolated three mutants with reduced plasticity. This assay system expands the opportunities for studying the molecular and cellular mechanisms of behavioural plasticity in C. elegans...
  69. pmc Modulation of ethylene responses affects plant salt-stress responses
    Wan Hong Cao
    National Key Lab of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    Plant Physiol 143:707-19. 2007
    ..6. In addition, the transgene NTHK1 mRNA was accumulated under salt stress, suggesting a posttranscriptional regulatory mechanism. These findings imply that ethylene signaling may be required for plant salt tolerance...
  70. pmc Biology of moderately halophilic aerobic bacteria
    A Ventosa
    Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain
    Microbiol Mol Biol Rev 62:504-44. 1998
    ..The new information obtained is also expected to contribute to the development of novel biotechnological uses for these organisms...
  71. ncbi Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response
    Shuji Yokoi
    Center for Plant Environmental Stress Physiology, 1165 Horticulture Building, Purdue University, West Lafayette, IN 47907 1165, USA
    Plant J 30:529-39. 2002
    ..Together, these results implicate AtNHX2 and 5, together with AtNHX1, as salt tolerance determinants, and indicate that AtNHX2 has a major function in vacuolar compartmentalization of Na+...
  72. pmc Comprehensive transcriptional profiling of NaCl-stressed Arabidopsis roots reveals novel classes of responsive genes
    Yuanqing Jiang
    Department of Biological Sciences, University of Alberta, Edmonton, Canada
    BMC Plant Biol 6:25. 2006
    ....
  73. ncbi Molecular responses to drought, salinity and frost: common and different paths for plant protection
    Motoaki Seki
    Plant Mutation Exploration Team, Plant Functional Genomics Research Group, RIKEN Genomic Sciences Center, 3 1 1 Koyadai, Tsukuba 305 0074, Japan
    Curr Opin Biotechnol 14:194-9. 2003
    ..In this review, we highlight recent findings on the gene expression associated with stress responses and the signaling pathways that are either common or specific to the response...
  74. pmc ABR1, an APETALA2-domain transcription factor that functions as a repressor of ABA response in Arabidopsis
    Girdhar K Pandey
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant Physiol 139:1185-93. 2005
    ....
  75. ncbi Hydrogen-rich saline attenuates radiation-induced male germ cell loss in mice through reducing hydroxyl radicals
    Yunhai Chuai
    Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, People s Republic of China
    Biochem J 442:49-56. 2012
    ..Our results represent the first in vivo evidence in support of a radioprotective role of H2 by neutralizing •OH in irradiated tissue with no side effects...
  76. pmc Involvement of Arabidopsis histone deacetylase HDA6 in ABA and salt stress response
    Li Ting Chen
    Institute of Plant Biology, College of Life Science, National Taiwan University, Taipei 10617, Taiwan
    J Exp Bot 61:3345-53. 2010
    ..Our study indicates that HDA6-involved histone modifications modulate seed germination and the salt stress response, as well as ABA- and salt stress-induced gene expression in Arabidopsis...
  77. ncbi The Arabidopsis TSPO-related protein is a stress and abscisic acid-regulated, endoplasmic reticulum-Golgi-localized membrane protein
    Damien Guillaumot
    Institut des Sciences de la Vie, Molecular Physiology Group, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Plant J 60:242-56. 2009
    ..Taken together, these results suggest that AtTSPO is a highly regulated protein, induced by abiotic stress to modulate, at least in part, transient intracellular ABA-dependent stress perception and/or signalling...
  78. ncbi Effect of sodium chloride on the gelation temperature, gel strength and bioadhesive force of poloxamer gels containing diclofenac sodium
    C S Yong
    College of Pharmacy, Yeungnam University, 214-1 Dae-dong, Gyongsan 712-749, South Korea
    Int J Pharm 226:195-205. 2001
    ..To develop a liquid suppository system using sodium chloride instead of bioadhesive polymers, the physicochemical properties such as gelation temperature, gel strength ..
  79. pmc Loss of halophytism by interference with SOS1 expression
    Dong Ha Oh
    Department of Plant Biology, University of Illinois at Urbana Champaign, Urbana, Illinois 61801, USA
    Plant Physiol 151:210-22. 2009
    ..Reduction in SOS1 expression changed Thellungiella that normally can grow in seawater-strength sodium chloride solutions into a plant as sensitive to Na(+) as Arabidopsis.
  80. pmc CIPK3, a calcium sensor-associated protein kinase that regulates abscisic acid and cold signal transduction in Arabidopsis
    Kyung Nam Kim
    Department of Plant and Microbial Biology, University of California, Berkeley, California 94720, USA
    Plant Cell 15:411-23. 2003
    ..Because the cold signaling pathway is largely independent of endogenous ABA production, CIPK3 represents a cross-talk "node" between the ABA-dependent and ABA-independent pathways in stress responses...
  81. pmc CBL1, a calcium sensor that differentially regulates salt, drought, and cold responses in Arabidopsis
    Yong Hwa Cheong
    Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720, USA
    Plant Cell 15:1833-45. 2003
    ..These studies suggest that CBL1 functions as a positive regulator of salt and drought responses and a negative regulator of cold response in plants...
  82. ncbi Links between dietary salt intake, renal salt handling, blood pressure, and cardiovascular diseases
    Pierre Meneton
    Institut National de la Santé et de la Recherche Médicale U367, Département de Santé Publique et d Informatique Médicale, Faculté de Médecine Broussais Hôtel Dieu, Paris, France
    Physiol Rev 85:679-715. 2005
    ..Thus chronic exposure to a high-salt diet appears to be a major factor involved in the frequent occurrence of hypertension and cardiovascular diseases in human populations...
  83. ncbi Arabidopsis root K+-efflux conductance activated by hydroxyl radicals: single-channel properties, genetic basis and involvement in stress-induced cell death
    Vadim Demidchik
    Department of Biological Sciences, University of Essex, Colchester, Essex CO4 5AP, UK
    J Cell Sci 123:1468-79. 2010
    ..Overall, this study provides new insight into the regulation of plant cation transport by ROS and demonstrates possible physiological properties of plant HR-activated K(+) channels...
  84. ncbi Integrative functional genomics of salt acclimatization in the model legume Lotus japonicus
    Diego H Sanchez
    Max Planck Institute for Molecular Plant Physiology, Wissenschaftspark Golm, Am Muhlenberg 1, Potsdam Golm, D 14476, Germany
    Plant J 53:973-87. 2008
    ..A simple qualitative model is proposed to explain the systems behaviour of plants during salt acclimatization...
  85. ncbi Effect of sodium chloride on the release, absorption and safety of diclofenac sodium delivered by poloxamer gel
    Young Joon Park
    College of Pharmacy, Seoul National University, San 56 1, Shinlim Dong, Kwanak Ku, Seoul 151 742, South Korea
    Int J Pharm 263:105-11. 2003
    Poloxamer solutions prepared with poloxamers and sodium chloride were previously reported to undergo a phase transition to bioadhesive gels at body temperature...
  86. ncbi Tantalizing evidence for caspase-like protein expression and activity in the cellular stress response of Archaea
    Kelly A Bidle
    Department of Biology, Rider University, Lawrenceville, NJ, USA
    Environ Microbiol 12:1161-72. 2010
    ..By playing a role in normal cell function, caspase-like proteases in Archaea appear to have co-evolved with other metabolic pathways, broadening their biological roles beyond apoptosis and cell death...
  87. ncbi Functional characterization of a plasma membrane Na+/H+ antiporter from alkali grass (Puccinellia tenuiflora)
    Xin Wang
    Key Laboratory of Forest Tree Genetics Improvement and Biotechnology, Ministry of Education, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China
    Mol Biol Rep 38:4813-22. 2011
    ..This suggests that overexpression of PtNHA1 results in enhanced ROS-scavenging enzymes of transgenic plants under NaCl salt stress...
  88. pmc Ionic strength-dependent persistence lengths of single-stranded RNA and DNA
    Huimin Chen
    School of Applied and Engineering Physics, Cornell University, Ithaca, NY 14853, USA
    Proc Natl Acad Sci U S A 109:799-804. 2012
    ..Our results illustrate the complex interplay between conformation and ion environment that modulates nucleic acid function in vivo...
  89. ncbi Common and divergent physiological, hormonal and metabolic responses of Arabidopsis thaliana and Thellungiella halophila to water and salt stress
    Vicent Arbona
    Ecofisiologia i Biotecnologia, Departament de Ciencies Agraries i del Medi Natural, Universitat Jaume I, Campus de Riu Sec, E 12071 Castello de la Plana, Spain
    J Plant Physiol 167:1342-50. 2010
    ..Overall, data indicated that physiological responses in Arabidopsis are induced after stress imposition through hormonal regulation whereas Thellungiella has a basal metabolic configuration, better prepared to endure environmental cues...
  90. pmc Linking the salt transcriptome with physiological responses of a salt-resistant Populus species as a strategy to identify genes important for stress acclimation
    Monika Brinker
    Büsgen Institut, Forstbotanik und Baumphysiologie, Georg August Universitat Gottingen, 37077 Goettingen, Germany
    Plant Physiol 154:1697-709. 2010
    ..In conclusion, by dissecting the stress transcriptome of tolerant species, novel genes important for salt endurance can be identified...
  91. pmc The expression of aquaporin-1 in the medulla of the kidney is dependent on the transcription factor associated with hypertonicity, TonEBP
    Miguel A Lanaspa
    Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Denver, Colorado 80045, USA
    J Biol Chem 285:31694-703. 2010
    ..In conclusion, these data demonstrate that TonEBP is necessary for the regulation of AQP1 expression in the inner medulla of the kidney under hypertonic conditions...
  92. ncbi Increasing nitric oxide content in Arabidopsis thaliana by expressing rat neuronal nitric oxide synthase resulted in enhanced stress tolerance
    Hai Tao Shi
    Key Lab of the Ministry of Education for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan 430072, PR China
    Plant Cell Physiol 53:344-57. 2012
    ..The approach may also be useful for genetic engineering of crops with increased environmental adaptations...
  93. pmc Global gene expression analysis of transgenic, mannitol-producing, and salt-tolerant Arabidopsis thaliana indicates widespread changes in abiotic and biotic stress-related genes
    Zhulong Chan
    Wuhan Botanical Garden, Chinese Academy of Sciences, Wuhan 430074, PR China
    J Exp Bot 62:4787-803. 2011
    ..These data indicate that mannitol-enhanced stress tolerance is due at least in part to increased expression of a variety of stress-inducible genes...
  94. ncbi Changes in the plant proteome resulting from salt stress: toward the creation of salt-tolerant crops?
    Hamid Sobhanian
    Payame Noor University, Tehran 19395 4697, Iran
    J Proteomics 74:1323-37. 2011
    ..In this review, we describe the physiological and biological changes in the proteomes of several important food crops under salt stress. We also provide a viewpoint into how proteomics-based research is likely to develop in this field...
  95. ncbi Hydrogen-rich saline protects against renal ischemia/reperfusion injury in rats
    Fei Wang
    Department of Anesthesiology, Changhai Hospital, Shanghai, China
    J Surg Res 167:e339-44. 2011
    ..This study was designed to investigate the effect of hydrogen-rich saline on renal ischemia/reperfusion (I/R) injury in rats...
  96. ncbi Molecular characterization of PeSOS1: the putative Na(+)/H (+) antiporter of Populus euphratica
    Yuxia Wu
    Cold and Arid Regions Environment and Engineering Research Institute, The Chinese Academy of Sciences, Lanzhou, PR China
    Plant Mol Biol 65:1-11. 2007
    ..These results suggest that PeSOS1 may play an essential role in the salt tolerance of P. euphratica and may be useful for improving salt tolerance in other tree species...
  97. pmc Identification of an apoplastic protein involved in the initial phase of salt stress response in rice root by two-dimensional electrophoresis
    Lei Zhang
    Institute of Molecular and Cell Biology, Hebei Normal University, Shijiazhuang 050016, China
    Plant Physiol 149:916-28. 2009
    ..These results indicate that plant apoplastic proteins may have important roles in the plant salt stress response...
  98. ncbi Identification of AtHD2C as a novel regulator of abscisic acid responses in Arabidopsis
    Sunandini Sridha
    Department of Biology, West Virginia University, Morgantown, WV 26506, USA
    Plant J 46:124-33. 2006
    ..The expression of several abscisic acid-responsive genes was affected in the 35S:AtHD2C-GFP plants. Our study provides evidence indicating that AtHD2C can modulate abscisic acid and stress responses...
  99. pmc Transcriptional profiling of pea ABR17 mediated changes in gene expression in Arabidopsis thaliana
    Sowmya S Krishnaswamy
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2P5, Canada
    BMC Plant Biol 8:91. 2008
    ..We hypothesized that a study of differences in transcriptome between wild type (WT) and ABR17 transgenic A. thaliana may shed light on this process...
  100. ncbi osa-MIR393: a salinity- and alkaline stress-related microRNA gene
    Peng Gao
    Plant Bioengineering Laboratory, Northeast Agricultural University, Harbin, 150030, China
    Mol Biol Rep 38:237-42. 2011
    ..These results illustrate that over-expression of osa-MIR393 can negatively regulate rice salt-alkali stress tolerance...
  101. ncbi Salt-induced modulation of the pathway of amyloid fibril formation by the mouse prion protein
    Shweta Jain
    National Centre for Biological Sciences, Tata Institute of Fundamental Research, Bangalore 560065, India
    Biochemistry 49:7615-24. 2010
    ....

Research Grants62

  1. Exercise training and blood pressure in hypertension: integrated mechanisms
    Noreen F Rossi; Fiscal Year: 2012
    ..exercise trainin on renin release, plasma and renal tissue Ang II and renal sodium excretion via the distal sodium chloride co-transporter (NCC) and epithelial sodium channel (ENaC)...
  2. DNA Damage and Response in the Bladder Microenvironment.
    Bradley P Dixon; Fiscal Year: 2013
    ..epithelial cell lines from the H-2Kb- tsA58 mouse will be gradually adapted to hyperosmolal conditions with sodium chloride or urea, or maintained in isoosmolal conditions, then exposed to different forms of DNA damage...
  3. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
  4. The Relationship Between STK39, Salt Sensitivity, and HCTZ-induced BP Response
    YEN PEI CHRISTY CHANG; Fiscal Year: 2010
    ..associated with higher versus lower baseline BP to perform 2 interventions that specifically test renal sodium chloride handling...
  5. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..ion transporters in the nephron to hydrochlorothiazide, amiloride, or furosemide, as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-potassium chloride cotransporter (NKCC), ..
  6. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..Future intervention trials will address these metabolic and nutritional issues, to reduce early ART mortality and improve ART outcomes in resource-constrained settings. ..
  7. Sodium Chloride Cotransporter Regulation by WNK Kinase
    Hui Cai; Fiscal Year: 2010
    ..Its clinical features are reversed by a thiazide diuretic, a sodium chloride cotransporter (NCC) inhibitor...
  8. Mechanisms of Hormonal Regulation of the Sodium Chloride Cotransporter
    Robert S Hoover; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The thiazide-sensitive sodium chloride cotransporter (NCC) is one of the key determinants of salt balance and thus systemic blood pressure...
  9. Analysis of distal conboluted tubule function in vivo
    James A McCormick; Fiscal Year: 2012
    ..convoluted tubule (DCT) of the kidney plays a critical role in the reabsorption of sodium (primarily via the sodium chloride cotransporter, NCC) and hence in regulation of blood pressure...
  10. Sodium-chloride co-transporter regulation in the kidney
    Alicia A McDonough; Fiscal Year: 2013
    ....
  11. EICOSANOIDS, VASCULAR TONE AND BLOOD PRESSURE
    WILLIAM BRYSON CAMPBELL; Fiscal Year: 2010
    ..pressure will also be measured in WT, TG or KO mice made hypertensive with desoxycorticosterone acetate/1% sodium chloride (DOCA-salt), angiotensin II or a NO synthase inhibitor...
  12. Multigene Kinase Network, Kidney Transport and Salt in Essential Hypertension
    Paul A Welling; Fiscal Year: 2010
    ..pathway to regulate the activity of a key renal salt transport protein, the thiazide diuretic sensitive sodium chloride co- transporter (NCC);3) Aberrant gain-of-STK39 signaling causes an inappropriate increase in NCC activity, ..
  13. The Role of Ubiquitin in Sodium Chloride Co-Transporter Regulation
    BENJAMIN S KO; Fiscal Year: 2012
    ..the mechanisms involved in the regulation of one of the key salt-handling transporters in the kidney, the sodium chloride co- transporter (NCC) located in distal convoluted tubule...
  14. Regulation of the Endocytic Trafficking of CFTR
    Agnieszka Swiatecka-Urban; Fiscal Year: 2012
    ..CF patients cannot move salt (sodium chloride) into and out of certain cells, including those that line the lungs and pancreas and as a result produce ..
  15. A highly multiplexed, scalable ultrananocrystalline diamond microarray sensor for
    Donato M Ceres; Fiscal Year: 2013
    ..Also, a greater understanding of selective sensing would enable alternative applications for the technology, including: low-cost, chronic, in vivo sensors for neurotransmitters, alcohol, metabolites and disease biomarkers. ..
  16. REGULATION OF THE SODIUM CHLORIDE COTRANSPORTER
    Robert S Hoover; Fiscal Year: 2010
    ..I have studied the regulation of the rat thiazide-sensitive sodium chloride cotransporter (rNCC) by glycosylation and phosphorylation for that period of time...
  17. Alcohol intake and aversion during adolescence in 8 inbred mouse strains
    EILEEN MARIE MOORE; Fiscal Year: 2011
    ....
  18. Development of Experimental and Computational Models for Traumatic Aortic Rupture
    Kurosh Darvish; Fiscal Year: 2009
    ..The finite element model will be used as a tool to conduct a parametric study to identify the loading conditions with higher risk of TAR and to analyze the injury mitigation strategies. ..
  19. Mechanisms of fibril formation in light chain amyloidosis
    DOUGLAS J MARTIN; Fiscal Year: 2011
    ..by systematically addressing the role of key physiological factors, such as protein concentration, pH, urea, sodium chloride, temperature, and polyethylene glycol (a molecular crowding agent) in amyloid formation...
  20. Biomarker Collection and Analysis in the PRESERVE Trial Cohort
    Steven Weisbord; Fiscal Year: 2013
    ..angiography to compare the effectiveness of intravenous (IV) isotonic sodium bicarbonate with IV isotonic sodium chloride and oral N- acetylcysteine with oral placebo for the prevention of serious adverse outcomes (i.e...
  21. Inulin immunoassay for kidney function
    Ernest V Groman; Fiscal Year: 2013
    ..Completion of Phase II will see the launch of two products and one service. The two products are inulin in sodium chloride injection, USP, and a cGMP FIT-GFR inulin kit...
  22. Electropolishing of Nitinol Stents in Aqueous, Acid Free Solutions
    MARIA E INMAN; Fiscal Year: 2013
    ..FARADAYIC ElectroPolishing will provide a uniformly smooth surface using a simple salt solution, such as sodium chloride or sodium nitrate...
  23. Sodium Chloride Induced Dysregulation of CD4+CD25+ Regulatory T Cells in Patients
    AMANDA HERNANDEZ; Fiscal Year: 2013
    ..The results of these proposed experiments may shed light on a potential environmental cause of MS and provide a novel treatment strategy. ..
  24. Functional Polymer Matrixes for Site-Specific, Image Guided Drug Delivery
    Agata A Exner; Fiscal Year: 2010
    ..Examples include enhancing radiofrequency ablation by delivering sodium chloride to increase tissue conductivity, improving successes of image guided biopsy by delivering hemostasis agents ..
  25. Taste psychophysics of bitter phytochemicals
    MIRIAM LINSCHOTEN; Fiscal Year: 2005
    ..Detection thresholds for the five phytochemicals and sodium chloride and PROP will be determined with a maximum likelihood adaptive staircase method...
  26. ABSORPTION, SECRETION, MALABSORPTION AND DIARRHEA
    JOHN FORDTRAN; Fiscal Year: 2002
    ..3) to explore the pathogenesis of idiopathic chronic diarrhea, especially in regard to ileal malabsorption of sodium chloride and bile acids; 4) to study the pathogenesis of diarrhea when it occurs as part of "Gulf War Syndrome"; 5) to ..
  27. TAS::75 0849::TAS
    Sunnie Kim; Fiscal Year: 2010
    ..For specificity, 25 non-target DNA sequence sample will be tested. For reliability testing, target DNA spiked samples will be retested twice and at 24-hour intervals and reliability coefficients calculated. ..
  28. GUSTATORY CHEMOSENSITIVITY OF THE ORAL PALATE
    INGLIS MILLER; Fiscal Year: 1980
    ..Concentration-response relationships are determined for sodium chloride, ammonium chloride, sucrose, hydrochloric acid and quinine hydrochloride...
  29. BLOOD TISSUE IRON DEPLETION BY EXTRACORPOREAL CHELATOR
    CLARA AMBRUS; Fiscal Year: 1991
    ..The above Phase I studies will test the feasibility of this approach to iron chelation and identify the final chelator for the prototype to be developed in Phase II...
  30. CONTROL OF SODIUM INTAKE IN THE HINDLIMB UNWEIGHTED RAT
    J Cunningham; Fiscal Year: 2005
    ..Additionally, these data may contribute to understanding of health problems associated with an aging population and with cardiovascular disease such as congestive heart failure. ..
  31. INTRAVENOUS FLUID THERAPY AND HEAD INJURY
    Steven Shackford; Fiscal Year: 1990
    ..The fluids to be compared are Ringer's lactate, hypertonic sodium lactate, 6% hydroxyethyl starch in 0.9% sodium chloride, and 7...
  32. COCAINE AND PERINATAL CEREBRAL AND UMBILICAL VESSELS
    Michael Schreiber; Fiscal Year: 1992
    ..These studies will provide a better understanding of the vascular effects of cocaine on the developing fetal neurovasculature and of the clinical neurological complications associated with prenatal cocaine abuse...
  33. Micropackage Technology for Implantable Biomedical Microsystems
    WEN H KO; Fiscal Year: 2013
    ....
  34. LASER ACOUSTIC EVALUATION OF DENTAL MATERIALS BONDING
    EVAN GREENER; Fiscal Year: 1993
    ..In addition, both conventional and LAETT test methods will be applied to quantify the dentin bonding strengths of commercial dentin bonding agents and their degradation under saline solution storage...
  35. SODIUM CHLORIDE AND HYPERTENSION
    Theodore Kotchen; Fiscal Year: 1990
    ....
  36. DIET SALT, CALCIUM KIDNEY STONES, BONE IN STONE FORMERS
    Linda Massey; Fiscal Year: 2001
    DESCRIPTION (Scanned from the applicant's description): Increases in dietary salt, i.e. sodium chloride (NaCI), increase urinary calcium over the range of intakes commonly consumed...
  37. KHCO3 PREVENTS NACL INDUCED BONE RESORPTION IN HUMANS?
    Anthony Sebastian; Fiscal Year: 1999
    Diets containing abundant sodium chloride lead to a drain of calcium from bone, the body's major calcium reserve, into the urine...
  38. VOLTAGE CLAMP PROBE OF TASTE RESPONSES IN DEVELOPMENT
    John DeSimone; Fiscal Year: 2003
    ..Changes in taste sensitivity to sodium chloride with early postnatal development are especially clear...
  39. NEURAL CONTROL OF FLUID HOMEOSTASIS IN HYPERTENSION
    Gregory Fink; Fiscal Year: 2001
    ..This is particularly the case where dietary sodium chloride (salt) intake is high...
  40. Passive Cavitation Imaging for Guidance and Control of Ultrasound Ablation
    T Douglas Mast; Fiscal Year: 2010
    ....
  41. INTRARENAL ANGIOTENSINOGEN: LOCALIZATION & REGULATION
    Julie Ingelfinger; Fiscal Year: 1990
    ..and its mRNA by factors known to influence the renin-angiotensin system, focusing on the role of sodium chloride. For comparison we will also examine the effects these physiological manipulations on levels of other ..
  42. Sealing Lobectomy Air Leaks by Inductive Coagulation
    KEVIN MARCHITTO; Fiscal Year: 2006
    ..After development of a more flexible adhesive consisting of albumin, sodium chloride and a plastisizer, the system will be used to seal raw lung tissue, and the integrity of the seal will be ..
  43. MECHANISMS AND CONSEQUENCES OF RENAL HYPERTENSION
    David Warnock; Fiscal Year: 1991
    ..models of essential hypertension and in experimental renal hypertension, renal epithelial intracellular sodium chloride concentrations (electron microprobe), hormonal and endothelial regulation of renal vascular reactivity and ..
  44. STRESS, SODIUM, AND BLOOD PRESSURE REGULATION
    Thomas Pickering; Fiscal Year: 1990
    ..They will not be asked to change their diets, but will be asked to take either slow-release sodium chloride capsules, or matching placebo. They will also collect overnight urine samples every two weeks...
  45. CHARACTERIZATION OF CHROMATIN SUBUNITS
    RANDOLPH RILL; Fiscal Year: 1980
    ..Work in progress is designed to determine the relationships between specific non-histone proteins and specifci gene sequences or DNA functions...
  46. Near Infrared Semiconductor Nanocrystal for Imaging Guided Surgery
    Tiecheng Qiao; Fiscal Year: 2009
    ..It is anticipated that the reduced costs and higher resolutions will permit more complete tumor resections, more accurate biopsies, and faster procedures with better patient outcomes and lower patient cost and morbidity. ..
  47. CHEMORECEPTION FOR INSOLUBLE SUBSTANCES--STARCH & OIL
    Israel Ramirez; Fiscal Year: 1993
    ..The role of ionic and other physical effects of dispersed solids will be examined by adding sodium chloride and chilling starch dispersions offered to rats...
  48. CARDIAC PEPTIDES IN THE CONTROL OF BLOOD VOLUME
    John Dietz; Fiscal Year: 1993
    ..plasma renin activity and blood pressure, 4) to examine the effect of pro-ANF (31-67) on renal flow, GFR, sodium chloride excretion, water excretion and renin secretion in the isolated perfused kidney, 5) to compare the secretion ..
  49. MICROCIRCULATORY FUNCTION IN HYPOTENSION
    JULIAN LOMBARD; Fiscal Year: 1980
    ..This research should contribute to our understanding of the cause of irreversibility in shock and aid in the development of effective therapeutic approaches to low flow states...
  50. DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER
    DAVID EDELL; Fiscal Year: 1999
    ..Other applications include telemetry of data on demand for all implantable biosensor systems. A small market for physiology applications may also exist. ..
  51. SURGICAL STUDIES OF INTESTINAL SEROTONIN
    John Kellum; Fiscal Year: 2005
    ..It is hoped that a better understanding of the physiologic role of intestinal mucosal 5-HT will lead to improved understanding of normal and abnormal human intestinal transport. ..
  52. CONTINUOUS-FLOW SYSTEM FOR HYBRIDOMA MICROENCAPSULATION
    HARRIS GOLD; Fiscal Year: 1990
    ..gels from a calcium chloride gelling solution and their subsequent introduction into a biologically isotonic sodium chloride solution and (2) to develop a droplet generator that can produce gel balls having diameters of about one-..
  53. MINORITY SCHOOL FACULTY DEVELOPMENT AWARD
    HERBERT ASHLINE; Fiscal Year: 1992
    ..is induced by clipping the renal artery, and the DOCA-salt model wher hypertension is induced by giving sodium chloride and a mineralocortcoid...
  54. Modular Radiopharmaceutical Processing and Delivery Unit
    RAYMOND BOISSEAU; Fiscal Year: 2004
    ..Apply a comprehensive failure-mode analysis to the total system design to identify and eliminate potential safety issues resulting from multiple component and procedural failures. ..
  55. TRANSCAPILLARY MOVEMENT IN SKELETAL MUSCLE
    Philip Watson; Fiscal Year: 1991
    ..wall of resting muscle mainly through pathways which largely exclude small molecules the size of sucrose and sodium chloride. This hypothesis is a major change from the conventional view that most water flow occurs through pathways ..
  56. TASTE AND AGING
    Linda Bartoshuk; Fiscal Year: 1980
    ..elderly subjects and young (college aged) control subjects will scale the perceived intensities of sucrose, sodium chloride, citric acid, and quinine hydrochloride as well as the perceived loudness of sounds...
  57. Insulating Coating for Implant Devices & Ribbon Cables
    VINAY SAKHRANI; Fiscal Year: 2001
    ..These implants and cables have to be protected with insulating barrier coatings to resist the penetration of biological fluids. ..
  58. DYNAMIC ENHANCEMENT OF DIALYSIS EFFICIENCY
    STEVEN AFRICK; Fiscal Year: 1999
    ..If disposable parts are necessary the market would be larger. ..
  59. CONTEXT EFFECTS IN THE PERCEPTION OF SENSORY MAGNITUDE
    Lawrence Marks; Fiscal Year: 2001
    ..For instance, a solution of sodium chloride at 0...
  60. Sodium-chloride co-transporter regulation in the kidney
    ALAN S YU; Fiscal Year: 2010
    ..abstract_text> ..
  61. Cellular Mechanisms for Tubuloglomerular Feedback
    Phillip Bell; Fiscal Year: 2009
    ..We have found that increases in luminal fluid sodium chloride concentration ([NaCI]L) activate a maxi anion channel leading to the movement of ATP across the basolateral ..
  62. COMPENSATORY HYPERTROPHY OF THE KIDNEY
    Jill Norman; Fiscal Year: 1991
    ..medium will be stimulated to hypertrophy by prolonged exposure to insulin, prostaglandin E1 and hypertonic sodium chloride. The existence of a luminal Na-H antiporter will be demonstrated by measuring Na influx kinetics and H+ ..