silicones

Summary

Summary: A broad family of synthetic organosiloxane polymers containing a repeating silicon-oxygen backbone with organic side groups attached via carbon-silicon bonds. Depending on their structure, they are classified as liquids, gels, and elastomers. (From Merck Index, 12th ed)

Top Publications

  1. ncbi Cellular microarrays for use with capillary-driven microfluidics
    Robert Lovchik
    IBM Research GmbH, Zurich Research Laboratory, 8803, Ruschlikon, Switzerland
    Anal Bioanal Chem 390:801-8. 2008
  2. ncbi The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications
    Pierre Jean Wipff
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Biomaterials 30:1781-9. 2009
  3. ncbi Asymptomatic corneal staining associated with the use of balafilcon silicone-hydrogel contact lenses disinfected with a polyaminopropyl biguanide-preserved care regimen
    Lyndon Jones
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 79:753-61. 2002
  4. ncbi Impact of a rub and rinse on solution-induced corneal staining
    Rachael C Peterson
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Canada ON N2L 3G1
    Optom Vis Sci 87:1030-6. 2010
  5. ncbi Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices
    Jessamine Ng Lee
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Anal Chem 75:6544-54. 2003
  6. pmc Proteomic analysis of protein deposits on worn daily wear silicone hydrogel contact lenses
    Zhenjun Zhao
    Institute for Eye Research, Sydney, NSW, Australia
    Mol Vis 14:2016-24. 2008
  7. ncbi Silicones in the rehabilitation of burns: a review and overview
    E Van den Kerckhove
    Department of Physical Medicine and Rehabilitation and Burns and Plastics, Herestraat 49, 3000, Leuven, Belgium
    Burns 27:205-14. 2001
  8. ncbi Bacteria and granulation tissue associated with Montgomery T-tubes
    Frank Schmäl
    Department of Otolarynology, University Hospital Muenster, Germany
    Laryngoscope 113:1394-400. 2003
  9. ncbi Evaluation of hardness and surface roughness of two maxillofacial silicones following disinfection
    Marcelo Coelho Goiato
    Department of Dental Materials and Prosthesis, School of Dentistry of Aracatuba, Sao Paulo State University, Aracatuba, SP, Brazil
    Braz Oral Res 23:49-53. 2009
  10. pmc Impact of a rinse step on protein removal from silicone hydrogel contact lenses
    Andrew D Pucker
    The Ohio State University College of Optometry, Columbus, Ohio 43218 2342, USA
    Optom Vis Sci 86:943-7. 2009

Detail Information

Publications262 found, 100 shown here

  1. ncbi Cellular microarrays for use with capillary-driven microfluidics
    Robert Lovchik
    IBM Research GmbH, Zurich Research Laboratory, 8803, Ruschlikon, Switzerland
    Anal Bioanal Chem 390:801-8. 2008
    ..The possibility of sealing CSs with cells arrayed on poly(dimethylsiloxane) may provide a versatile platform for high-throughput experimentation down to the single-cell level...
  2. ncbi The covalent attachment of adhesion molecules to silicone membranes for cell stretching applications
    Pierre Jean Wipff
    Ecole Polytechnique Federale de Lausanne, Switzerland
    Biomaterials 30:1781-9. 2009
    ..Hence, covalent linkage of adhesive molecules is superior to non-covalent methods in providing a coating that resists large deformations and that fully transmit this stretch to cultured cells...
  3. ncbi Asymptomatic corneal staining associated with the use of balafilcon silicone-hydrogel contact lenses disinfected with a polyaminopropyl biguanide-preserved care regimen
    Lyndon Jones
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 79:753-61. 2002
    ..To compare subjective symptoms and signs in a group of individuals who wear silicone-hydrogel lenses on a daily wear basis while they sequentially used two differing care regimens...
  4. ncbi Impact of a rub and rinse on solution-induced corneal staining
    Rachael C Peterson
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Canada ON N2L 3G1
    Optom Vis Sci 87:1030-6. 2010
    ..To investigate whether the inclusion of a rub and rinse step before contact lens disinfection has an impact on solution-induced corneal staining...
  5. ncbi Solvent compatibility of poly(dimethylsiloxane)-based microfluidic devices
    Jessamine Ng Lee
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Anal Chem 75:6544-54. 2003
    ..The feasibility of performing organic reactions in PDMS was demonstrated by performing a Diels-Alder reaction in a microchannel...
  6. pmc Proteomic analysis of protein deposits on worn daily wear silicone hydrogel contact lenses
    Zhenjun Zhao
    Institute for Eye Research, Sydney, NSW, Australia
    Mol Vis 14:2016-24. 2008
    ..In this study, we used proteomic techniques to analyze the protein deposits extracted from worn daily wear silicone hydrogel contact lenses in combination with different lens care solutions...
  7. ncbi Silicones in the rehabilitation of burns: a review and overview
    E Van den Kerckhove
    Department of Physical Medicine and Rehabilitation and Burns and Plastics, Herestraat 49, 3000, Leuven, Belgium
    Burns 27:205-14. 2001
    This article gives an overview of the use of silicones in the treatment and prevention of hypertrophic (burn related) scars. Of all non-invasive treatment modalities the use of continuous pressure and occlusive contact media, e.g...
  8. ncbi Bacteria and granulation tissue associated with Montgomery T-tubes
    Frank Schmäl
    Department of Otolarynology, University Hospital Muenster, Germany
    Laryngoscope 113:1394-400. 2003
    ..Although complications (infection, development of granulation tissue) of silicone Montgomery T-tubes have been reported, the microbiological consequences and the origin of granulation tissue have not yet been evaluated...
  9. ncbi Evaluation of hardness and surface roughness of two maxillofacial silicones following disinfection
    Marcelo Coelho Goiato
    Department of Dental Materials and Prosthesis, School of Dentistry of Aracatuba, Sao Paulo State University, Aracatuba, SP, Brazil
    Braz Oral Res 23:49-53. 2009
    The purpose of this study was to evaluate the Shore A hardness and surface roughness of two silicones for maxillofacial prosthetic treatment, under the influence of chemical disinfection and storage...
  10. pmc Impact of a rinse step on protein removal from silicone hydrogel contact lenses
    Andrew D Pucker
    The Ohio State University College of Optometry, Columbus, Ohio 43218 2342, USA
    Optom Vis Sci 86:943-7. 2009
    ..To determine the impact of the rinse step in "no rub" contact lens care systems relative to its ability to assist in removing loosely associated and bound tear film proteins from a worn silicone hydrogel lens...
  11. ncbi Poly(oxyethylene) based surface coatings for poly(dimethylsiloxane) microchannels
    Wibke Hellmich
    Experimental Biophysics and Applied Nanosciences, Physics Faculty, Bielefeld University, Germany
    Langmuir 21:7551-7. 2005
    ..Determination of the electroosmotic mobilities of these coatings in PDMS microchannels prove their use for electrokinetic applications in which EOF reduction is inevitable and protein adsorption has to be suppressed...
  12. ncbi Methods for detecting silicones in biological matrixes
    J J Kennan
    Dow Corning Corporation, Midland, Michigan 48686 0994, USA
    Anal Chem 71:3054-60. 1999
    ..microwave digestion of samples in acid solution to rapidly break down the biological matrix while hydrolyzing silicones to monomeric species...
  13. ncbi The effects of 2 week senofilcon-A silicone hydrogel contact lens daily wear on tear functions and ocular surface health status
    Murat Dogru
    Keio University School of Medicine, Johnson and Johnson Department of Ocular Surface and Visual Optics, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Cont Lens Anterior Eye 34:77-82. 2011
    ..To prospectively investigate the effects of 2 week senofilcon A contact lens (CL) daily wear on the functional visual acuity (VA), ocular surface and tear film...
  14. ncbi Quantification of protein deposits on silicone hydrogel materials using stable-isotopic labeling and multiple reaction monitoring
    Negar Babaei Omali
    Brien Holden Vision Institute, Sydney, Australia
    Biofouling 28:697-709. 2012
    ..The use of MRM-MS is a powerful analytical tool for the quantification of specific proteins from single contact lenses after wear...
  15. ncbi Contact lens deposits, adverse responses, and clinical ocular surface parameters
    Zhenjun Zhao
    Institute for Eye Research, Sydney, New South Wales, Australia
    Optom Vis Sci 87:669-74. 2010
    ..To correlate clinical responses during contact lens wear with the amount of protein or cholesterol extracted from lenses after wear...
  16. ncbi Quantification of non-polar lipid deposits on senofilcon a contact lenses
    Miriam Heynen
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 88:1172-9. 2011
    ....
  17. ncbi Importance of rub and rinse in use of multipurpose contact lens solution
    Hua Zhu
    Brien Holden Vision Institute, Level 5, North Wing, Rupert Myers Building, University of New South Wales, Sydney, NSW 2052, Australia
    Optom Vis Sci 88:967-72. 2011
    ..The aim of the study was to evaluate the effect of various regimen steps on the efficacy of MPDS when used with silicone hydrogel and conventional lenses...
  18. ncbi Surface modification of poly(dimethylsiloxane) microfluidic devices by ultraviolet polymer grafting
    Shuwen Hu
    Center for Biomedical Engineering, University of California, Irvine 92697, USA
    Anal Chem 74:4117-23. 2002
    ..By using the appropriate monomer, it should be possible to use UV grafting to impart a variety of surface properties to PDMS microfluidics devices...
  19. ncbi Systematic review: efficacy of silicone microimplants (Macroplastique) therapy for stress urinary incontinence in adult women
    Ph H ter Meulen
    Department of Urology, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands
    Eur Urol 44:573-82. 2003
    ..To assess the efficacy of silicone microimplants (Macroplastique; polydimethylsiloxane) therapy for stress urinary incontinence in adult women, using a systematic review of identified studies...
  20. ncbi Care regimen and lens material influence on silicone hydrogel contact lens deposition
    Zhenjun Zhao
    Institute for Eye Research, Sydney, Australia
    Optom Vis Sci 86:251-9. 2009
    ..To quantitatively detect proteins and cholesterol extracted from worn silicone hydrogel contact lenses and determine the effect of various lens care solutions on deposit accumulation...
  21. ncbi Prevalence of contact lens-related complications: UCLA contact lens study
    Julie F Y Forister
    Meredith W Morgan University Eye Center, University of California at Berkeley, 94720 2020, USA
    Eye Contact Lens 35:176-80. 2009
    ..This study is a cross-sectional analysis of the types and prevalence of contact lens (CL)-related complications among CL wearing patients seen in a university clinic setting...
  22. ncbi Corneal staining and subjective symptoms with multipurpose solutions as a function of time
    Renee J Garofalo
    Alcon Research, Ltd, Fort Worth, TX 76134 2099, USA
    Eye Contact Lens 31:166-74. 2005
    ..Short-term changes in corneal staining and ocular symptoms were assessed at defined intervals to evaluate combinations of three soft lenses and four multipurpose solutions...
  23. ncbi Deposition rates and lens care influence on galyfilcon A silicone hydrogel lenses
    Jason J Nichols
    The Ohio State University, College of Optometry, Columbus, Ohio 43210, USA
    Optom Vis Sci 83:751-7. 2006
    ..The purpose of this study is to investigate the frequency of deposition and impact of various multipurpose care regimens on a silicone hydrogel contact lens material (galyfilcon A; Acuvue Advance, Vistakon, Inc.)...
  24. ncbi Silicone colonization by non-Candida albicans Candida species in the presence of urine
    Sonia Silva
    Institute for Biotechnology and Bioengineering, Universidade do Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    J Med Microbiol 59:747-54. 2010
    ..tropicalis and C. parapsilosis strains, a fact that might explain the larger role of C. glabrata colonization and disseminated infections in hospitalized and catheterized patients...
  25. ncbi Detection and quantification of tear phospholipids and cholesterol in contact lens deposits: the effect of contact lens material and lens care solution
    Jennifer T Saville
    School of Chemistry, University of Wollongong, Wollongong, New South Wales, Australia
    Invest Ophthalmol Vis Sci 51:2843-51. 2010
    ..To examine the deposition of tear phospholipids and cholesterol onto worn contact lenses and the effect of lens material and lens care solution...
  26. ncbi Lipid deposition on silicone hydrogel lenses, part I: quantification of oleic Acid, oleic Acid methyl ester, and cholesterol
    E Peter Maziarz
    Bausch and Lomb, Inc, Rochester, NY 14603, USA
    Eye Contact Lens 32:300-7. 2006
    ..To investigate the sorption of oleic acid, oleic acid methyl ester, and cholesterol on currently marketed silicone hydrogel contact lenses...
  27. ncbi Kinetics of in vitro lactoferrin deposition on silicone hydrogel and FDA group II and group IV hydrogel contact lens materials
    Lisa M Chow
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, Canada N2L 3G1
    J Biomater Sci Polym Ed 20:71-82. 2009
    ..The kinetics of lactoferrin deposition on contact lens materials depend on the chemical structure of the lens material...
  28. ncbi Complications associated with care product use during silicone daily wear of hydrogel contact lens
    Eric B Papas
    The Institute for Eye Research, The University of New South Wales, Sydney, NSW, Australia
    Eye Contact Lens 33:392-3; discussion 399-400. 2007
    ..Options for achieving this include use of low impact lens/MPS combinations, daily disposable lenses or hydrogen peroxide based disinfection systems...
  29. ncbi Immobilization of DNA onto poly(dimethylsiloxane) surfaces and application to a microelectrochemical enzyme-amplified DNA hybridization assay
    Daojun Liu
    Department of Chemistry, Texas A and M University, P O Box 30012, College Station, Texas 77842 3012, USA
    Langmuir 20:5905-10. 2004
    ..At present, the limit of detection of the DNA target is 1 nM in a volume of 20 nL, which corresponds to 20 attomoles of DNA...
  30. ncbi Color stability comparison of silicone facial prostheses following disinfection
    Marcelo Coelho Goiato
    Department of Dental Materials and Prosthodontics, UNESP Sao Paulo State University, Sao Paulo, Brazil
    J Prosthodont 18:242-4. 2009
    The purpose of this study was to evaluate the color stability of two silicones for use in facial prostheses, under the influence of chemical disinfection and storage time.
  31. ncbi Influence of day and night wear on surface properties of silicone hydrogel contact lenses and bacterial adhesion
    Pit B J Vermeltfoort
    Department of Biomedical Engineering, University Medical Center Groningen, and University of Groningen, Groningen, The Netherlands
    Cornea 25:516-23. 2006
    ..The aim of this study was to determine the effect of continuous wear on physicochemical surface properties of silicone hydrogel (S-H) lenses and their susceptibility to bacterial adhesion...
  32. ncbi Influence of investment, disinfection, and storage on the microhardness of ocular resins
    Marcelo Coelho Goiato
    Department of Dental Materials and Prosthodontics, School of Dentistry at Aracatuba, Sao Paulo State University UNESP, Brazil
    J Prosthodont 18:32-5. 2009
    ..The purpose of this study was to evaluate the effects of chemical disinfection and the method of investment on the microhardness of ocular prosthesis acrylic resin...
  33. ncbi Surface modification of poly(dimethylsiloxane) microchannels
    Honest Makamba
    National Research Laboratory for Advanced Biotechnology and Biomedical Microinstrumentation, Department of Chemistry, Division of Molecular and Life Sciences, Pohang University of Science and Technology, Pohang, South Korea
    Electrophoresis 24:3607-19. 2003
    ..Most of these applications require the use of aqueous or polar solvents, which makes surface modification a very important topic...
  34. ncbi Prevalence of ocular surface symptoms, signs, and uncomfortable hours of wear in contact lens wearers: the effect of refitting with daily-wear silicone hydrogel lenses (senofilcon a)
    Colleen Riley
    Johnson and Johnson Vision Care, Jacksonville, FL, USA
    Eye Contact Lens 32:281-6. 2006
    ..This study estimated the prevalence of problems in current wearers of soft contact lenses and tested the effect of refitting patients with senofilcon A silicone hydrogel lenses (ACUVUE Oasys)...
  35. ncbi [Different endotamponade agents and their clinical indications]
    K Engelmann
    Augenklinik, Klinikum Chemnitz gGmbH, Chemnitz
    Klin Monbl Augenheilkd 225:138-45. 2008
    ..An uncomfortable "head down" position of the patients after surgery is not necessary. Current research focuses on developing new heavy silicone oils with a lower tendency to emulsify...
  36. ncbi Microfluidic devices fabricated in poly(dimethylsiloxane) for biological studies
    Samuel K Sia
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Electrophoresis 24:3563-76. 2003
    ..The review emphasizes the advantages of miniaturization for biological analysis, such as efficiency of the device and special insights into cell biology...
  37. ncbi A comparison of regimen methods for the removal and inactivation of bacteria, fungi and Acanthamoeba from two types of silicone hydrogel lenses
    Simon Kilvington
    Department of Infection, Immunity and Inflammation, University of Leicester, Leicester, United Kingdom
    Cont Lens Anterior Eye 32:73-7. 2009
    ..To compare the antimicrobial efficacy of commercial contact lens solutions when used according to the manufacturers' recommended regimens with two types of silicone hydrogel lenses...
  38. ncbi Long-term in vivo biostability of poly(dimethylsiloxane)/poly(hexamethylene oxide) mixed macrodiol-based polyurethane elastomers
    Anne Simmons
    Graduate School of Biomedical Engineering, University of New South Wales, Sydney NSW 2052, Australia
    Biomaterials 25:4887-900. 2004
    ..The results indicate that a soft, flexible PDMS-based polyurethane synthesized using 20% PHMO and 80% PDMS macrodiols has excellent long-term biostability compared with commercially available polyurethanes...
  39. pmc The efficiency of contact lens care regimens on protein removal from hydrogel and silicone hydrogel lenses
    Doerte Luensmann
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, ON, Canada
    Mol Vis 16:79-92. 2010
    ....
  40. ncbi Conformational and quantitative characterization of lysozyme extracted from galyfilcon and senofilcon silicone hydrogel contact lenses
    Mary Ann Glasier
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Curr Eye Res 33:1-11. 2008
    ..To compare two solvents for retrieval of lysozyme deposited on a silicone hydrogel (SH) contact lens material galyfilcon A (GA; Acuvue Advance)...
  41. ncbi Interactions of lens care with silicone hydrogel lenses and effect on comfort
    Mark D P Willcox
    Brien Holden Vision Institute, The University of New South Wales, Sydney, New South Wales, Australia
    Optom Vis Sci 87:839-46. 2010
    ..The purpose of this study was to investigate the effect of lens care products on short-term subjective and physiological performance silicone hydrogel lenses...
  42. ncbi Impact of multipurpose solutions released from contact lenses on corneal cells
    Nicole C Tanti
    Department of Systems Design Engineering, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 88:483-92. 2011
    ..To assess, in vitro, the effect of the release of contact lens multipurpose solutions (MPS) from two silicone hydrogel lenses on human corneal epithelial cells...
  43. ncbi In vitro lipid deposition on hydrogel and silicone hydrogel contact lenses
    Andrew D Pucker
    Ohio State University, College of Optometry, Columbus, Ohio 43218 2342, USA
    Invest Ophthalmol Vis Sci 51:6334-40. 2010
    ..To understand various soft contact lens materials' ability to adsorb common tear lipids...
  44. pmc Corneal epithelial cell biocompatibility to silicone hydrogel and conventional hydrogel contact lens packaging solutions
    M B Gorbet
    Systems Design Engineering, University of Waterloo, Waterloo, Ontario, Canada
    Mol Vis 16:272-82. 2010
    ..The purpose of this study was to investigate the effect of various packaging solutions on HCECs, using an in vitro model...
  45. ncbi Confocal microscopy and albumin penetration into contact lenses
    Doerte Luensmann
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 84:839-47. 2007
    ..To develop a novel in vitro method to detect the depth of penetration of the tear film protein albumin into contact lens materials using confocal laser scanning microscopy (CLSM)...
  46. ncbi Comparative study of silicone-hydrogel contact lenses surfaces before and after wear using atomic force microscopy
    M Lira
    Department of Physics Optometry, School of Sciences, University of Minho, Portugal
    J Biomed Mater Res B Appl Biomater 85:361-7. 2008
    ..The aim of this study was to analyze surface changes of three silicone-hydrogel contact lenses after daily wear. The lenses used in this study were balafilcon A, lotrafilcon B (both surface-treated), and galyfilcon A (non surface-treated)...
  47. ncbi Calcinosis cutis with siliconomas complicated by hypercalcemia
    Seng Cheong Loke
    Department of Endocrinology, Tan Tock Seng Hospital, Singapore
    Endocr Pract 11:341-5. 2005
    ..To report a case of extensive calcinosis cutis presumably caused by silicone injections, which was complicated by hypercalcemia...
  48. ncbi The impact of lipid on contact angle wettability
    Holly Lorentz
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 84:946-53. 2007
    ..To analyze the effect of in vitro lipid doping on conventional hydrogel (CH) and silicone hydrogel (SH) lens wettability, assessed by sessile drop contact angle (CA) measurement...
  49. ncbi Protein deposition on a lathe-cut silicone hydrogel contact lens material
    Lakshman N Subbaraman
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 86:244-50. 2009
    ..To determine the quantity of total protein, total lysozyme, and the conformational state of lysozyme deposited on a novel, lathe-cut silicone hydrogel (SiHy) contact lens material (sifilcon A) after 3 months of wear...
  50. ncbi In vitro water wettability of silicone hydrogel contact lenses determined using the sessile drop and captive bubble techniques
    Carole Maldonado-Codina
    Eurolens Research, Faculty of Life Sciences, The University of Manchester, Manchester, United Kingdom
    J Biomed Mater Res A 83:496-502. 2007
    ..Contact angle analysis of hydrogel lens surfaces is highly methodologically dependent and may be able to predict the clinical performance of contact lenses in vivo...
  51. ncbi In vitro assessment of medical device toxicity: interactions of benzalkonium chloride with silicone-containing and p-hema-containing hydrogel contact lens materials
    Aphrodite Dracopoulos
    School of Optometry, Department of Biology, University of Waterloo, Waterloo, Ontario, Canada
    Eye Contact Lens 33:26-37. 2007
    ....
  52. ncbi Visual evaluation of color stability after accelerated aging of pigmented and nonpigmented silicones to be used in facial prostheses
    Daniela Nardi Mancuso
    Department of Dental Materials and Prosthodontics, Araçatuba Dental School, UNESP Sao Paulo State University, Aracatuba, Sao Paulo, Brazil
    Indian J Dent Res 20:77-80. 2009
    The objective of this study was to evaluate by a visual method of comparison the color stability of nonpigmented and pigmented facial silicones after accelerated aging.
  53. ncbi The influence of lens material and lens wear on the removal and viability of Staphylococcus epidermidis
    Lívia Santos
    Institute for Biotechnology and Bioengenhary, Centre of Biological Engineering, University of Minho, Braga, Portugal
    Cont Lens Anterior Eye 31:126-30. 2008
    ..Four silicone hydrogel materials (galyfilcon A, balafilcon A, lotrafilcon A, lotrafilcon B) and one conventional hydrogel material (etafilcon A) were assayed...
  54. ncbi Ex vivo protein deposition on bi-weekly silicone hydrogel contact lenses
    Adrienne Boone
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Optom Vis Sci 86:1241-9. 2009
    ..This study investigated the protein deposition that occurs on daily wear silicone hydrogel (SH) lenses, after 2 weeks of wear...
  55. ncbi Localization of lysozyme sorption to conventional and silicone hydrogel contact lenses using confocal microscopy
    Doerte Luensmann
    Centre for Contact Lens Research, University of Waterloo, Waterloo, Ontario, Canada
    Curr Eye Res 34:683-97. 2009
    ..To investigate the distribution profile of hen egg lysozyme (HEL) through poly-2-hydroxyethyl methacrylate (pHEMA)-based lens materials and silicone hydrogel (SH) lens materials using confocal laser scanning microscopy (CLSM)...
  56. pmc Contact lens physical properties and lipid deposition in a novel characterized artificial tear solution
    Holly Lorentz
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Mol Vis 17:3392-405. 2011
    ....
  57. ncbi Marginal deterioration of the silicone for facial prosthesis with pigments after effect of storage period and chemical disinfection
    Aimée Maria Guiotti
    Department of Dental Materials and Prosthodontics, Santa Fé do Sul Dental School, FUNEC, Santa Fé do Sul, Sao Paulo, Brazil
    J Craniofac Surg 21:142-5. 2010
    ..The use of disinfection did not contribute to the marginal deterioration of polymer (silicone), regardless of the pigmentation and artificial aging...
  58. ncbi Quantity and conformation of lysozyme deposited on conventional and silicone hydrogel contact lens materials using an in vitro model
    Maciej Suwala
    Centre for Contact Lens Research, School of Optometry, University of Waterloo, Waterloo, Ontario, Canada
    Eye Contact Lens 33:138-43. 2007
    ..To determine the activity of hen egg lysozyme (HEL) deposited on conventional and silicone hydrogel contact lens materials by using an in vitro model...
  59. ncbi Alloplastic template fixation of blow-out fracture
    Kun Hwang
    Department of Plastic Surgery, Inha University Hospital, Korea
    J Craniofac Surg 13:510-2. 2002
    ..This procedure is simple and secure, and intramaxillary packing is not needed to buttress the depressed fractured bone into the sinus...
  60. ncbi The effect of the environment on the mechanical properties of medical grade silicones
    L J Leslie
    Department of Mechanical Engineering, University of Birmingham, Edgbaston, Birmingham, UK
    J Biomed Mater Res B Appl Biomater 86:460-5. 2008
    ..of this research was to investigate the effect of the environment on the mechanical properties of medical grade silicones used for human implantation...
  61. ncbi Interesting case: Foreign body in the nose: an orbital silastic sheet had migrated into the nasal cavity
    C Groombridge
    Br J Oral Maxillofac Surg 43:56. 2005
  62. ncbi Influence of channel width on alignment of smooth muscle cells by high-aspect-ratio microfabricated elastomeric cell culture scaffolds
    John D Glawe
    Biomedical Engineering Program, Louisiana Tech University, Ruston, LA 71272, USA
    J Biomed Mater Res A 75:106-14. 2005
    ....
  63. ncbi Microfiber-directed boundary flow in press-fit microdevices fabricated from self-adhesive hydrophobic surfaces
    Tom T Huang
    Laboratory of Renewable Resources Engineering LORRE, School of Chemical Engineering, Purdue University, West Lafayette, Indiana 47907 2022, USA
    Anal Chem 77:3671-5. 2005
    ..The simplicity of this technique allows quick prototyping of microfluidic components, as well as complete biosensor systems, such as we describe for the detection of pathogenic bacteria...
  64. ncbi Bioactivity of wollastonite/aerogels composites obtained from a TEOS-MTES matrix
    Jose Antonio Toledo-Fernández
    Departamento Física de la Materia Condensada, Facultad de Ciencias, Universidad de Cadiz, Avenida República Saharaui, S N, 11510 Puerto Real, Cadiz, Spain
    J Mater Sci Mater Med 19:2207-13. 2008
    ..An apatite layer of spherical-shaped particles of uniform size smaller than 5 microns is observed to form on the surface of the aerogels after 25 days soaking in SBF...
  65. ncbi Three-dimensional control of protein patterning in microfabricated devices
    Guillaume Romet-Lemonne
    FOM Institute for Atomic and Molecular Physics, Kruislaan 407, 1098 SJ Amsterdam, The Netherlands
    Nano Lett 5:2350-4. 2005
    ....
  66. ncbi Control of cellular organization in three dimensions using a microfabricated polydimethylsiloxane-collagen composite tissue scaffold
    James J Norman
    Department of Biomedical Engineering, Boston University, MA 02215, USA
    Tissue Eng 11:378-86. 2005
    ..2 degrees in controls. The morphology of the cells was also affected by the PDMS scaffold. The nuclei were longer (1.25x) and thinner (0.75x) than in control gels; however, no changes in diameter of the cells in the z direction were seen...
  67. ncbi Development of a disposable infusion system for the delivery of protein therapeutics
    David T Eddington
    Division of Health Sciences and Technology, Harvard MIT, 77 Massachusetts Ave, E19 582, Cambridge, MA 02139, USA
    Biomed Microdevices 7:223-30. 2005
    ..As the hydrogel actuators expand, the expansion deflects the flexible membrane down and reduces the volume of the drug reservoir causing the infusion of drug through the needle that is the only outlet for the reservoir...
  68. ncbi Proteomic analysis of protein adsorption: serum amyloid P adsorbs to materials and promotes leukocyte adhesion
    Jin Ku Kim
    Department of Chemical Engineering, Washington University, St Louis, MS 63130, USA
    J Biomed Mater Res A 75:199-209. 2005
    ..The methods developed for these studies may be useful for the large-scale study of protein adsorption and do not rely on radiolabeling or the availability of antibodies...
  69. ncbi Rapid fabrication and chemical patterning of polymer microstructures and their applications as a platform for cell cultures
    K Faid
    Institute for Microstructural Sciences IMS, National Research Council of Canada, Ottawa, Ontario, K1A 0R6, Canada
    Biomed Microdevices 7:179-84. 2005
    ....
  70. ncbi Surface tethering of phosphorylcholine groups onto poly(dimethylsiloxane) through swelling--deswelling methods with phospholipids moiety containing ABA-type block copolymers
    Ji Hun Seo
    Department of Materials Engineering, School of Engineering and Center for NanoBio Integration, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Biomaterials 29:1367-76. 2008
    ..We conclude that this procedure is effective in fabricating biocompatible surfaces on PDMS substrates...
  71. ncbi A general method for patterning gradients of biomolecules on surfaces using microfluidic networks
    Xingyu Jiang
    Department of Chemistry and Chemical Biology, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Anal Chem 77:2338-47. 2005
    ..In this procedure, the relative amount of each protein, at saturation on the surface, depends only on its concentration.)...
  72. ncbi Micro-patterning of animal cells on PDMS substrates in the presence of serum without use of adhesion inhibitors
    Mauris N De Silva
    Department of Chemical Engineering and Materials Science, University of Minnesota, USA
    Biomed Microdevices 6:219-22. 2004
  73. ncbi Phase-changing sacrificial materials for solvent bonding of high-performance polymeric capillary electrophoresis microchips
    Ryan T Kelly
    Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602, USA
    Anal Chem 77:3536-41. 2005
    ..The simplicity of the methods presented here and the improved robustness of the resulting devices should facilitate the broader implementation of polymer microchips in microfluidic analyses...
  74. ncbi Bioactive heparin immobilized onto microfluidic channels in poly(dimethylsiloxane) results in hydrophilic surface properties
    Sara Thorslund
    Department of Engineering Sciences, Angstrom Laboratory, Uppsala University, Sweden
    Colloids Surf B Biointerfaces 46:240-7. 2005
    ....
  75. ncbi Fabrication improvements for thermoset polyester (TPE) microfluidic devices
    Gina S Fiorini
    Department of Chemistry, University of Washington, Seattle, WA, USA
    Lab Chip 7:923-6. 2007
    ..We also describe plasma-bonding of TPE to glass to create hybrid TPE-glass devices. We further present a simple master-pretreatment method to replace our original technique that required the use of specialized equipment...
  76. ncbi The analytical approach to polydimethylsiloxane microfluidic technology and its biological applications
    Emil P Kartalov
    Department of Biochemistry and Molecular Biology, Keck School of Medicine, University of Southern California, Norris Cancer Center, NOR6346, 1441 Eastlake Avenue, Los Angeles, California 90033, USA
    J Nanosci Nanotechnol 6:2265-77. 2006
    ..Finally, the body of work is reclassified in terms of addressed biological applications and compared to the standard methods in cellular and molecular biology, to offer insights for future devices and applications...
  77. pmc Leakage-free bonding of porous membranes into layered microfluidic array systems
    Bor han Chueh
    Department of Biomedical Engineering and Macromolecular Science and Engineering Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Anal Chem 79:3504-8. 2007
    ..The capability of this device for bioanalysis was demonstrated by measuring responses of cells to different color fluorescent reagents...
  78. ncbi Capillary kinetics of water in homogeneous, hydrophilic polymeric micro- to nanochannels
    Hoon Eui Jeong
    School of Mechanical and Aerospace Engineering, Seoul National University, Seoul, Korea
    Small 3:778-82. 2007
  79. ncbi Early keratinocyte differentiation on micropillar interfaces
    Thorsten Steinberg
    Department of Orthodontics and Dentofacial Orthopedics, Dental School, University of Heidelberg, Im Neuenheimer Feld 400, D 69120 Heidelberg
    Nano Lett 7:287-94. 2007
    ..Moreover, they form the basis to study cell functions such as differentiation in a defined topologically structured environment...
  80. ncbi Novel dome-shaped structures for high-efficiency patterning of individual microbeads in a microfluidic device
    Chee Tiong Lim
    Division of Bioengineering, Faculty of Engineering, Blk, E3 A 04, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Small 3:573-9. 2007
  81. ncbi Flowing lattices of bubbles as tunable, self-assembled diffraction gratings
    Michinao Hashimoto
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford St, Cambridge, MA, USA
    Small 2:1292-8. 2006
    ..For our devices, we achieved tunable ranges in pitch from 12 to 51 microm, corresponding to first-order diffraction angles from 3.2 degrees to 0.7 degrees for light with a wavelength of 632 nm...
  82. ncbi Biomimetic micropatterning of silica by surface-initiated polymerization and microcontact printing
    Dong Jin Kim
    Department of Chemistry and School of Molecular Science BK21, Center for Molecular Design and Synthesis, Korea Advanced Institute of Science and Technology, Daejeon 305 701, Korea
    Small 1:992-6. 2005
    ..The procedure could be extended to the controlled fabrication of silica patterns with any size, shape, or thickness...
  83. ncbi Open-access microfluidic patch-clamp array with raised lateral cell trapping sites
    Adrian Y Lau
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California Berkeley, Berkeley, CA 94720, USA
    Lab Chip 6:1510-5. 2006
    ..The results demonstrate that the system is capable of performing whole cell measurements and drug profiling in a more efficient manner than the traditional patch-clamp set-up...
  84. ncbi A micro-spherical heart pump powered by cultured cardiomyocytes
    Yo Tanaka
    Department of Applied Chemistry, School of Engineering, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8656, Japan
    Lab Chip 7:207-12. 2007
    ..We anticipate that this device might be applied for various purposes including a bio-actuator for medical implant devices that relies on biochemical energy, not electrical interfacing...
  85. ncbi Hepatocyte spheroid culture on a polydimethylsiloxane chip having microcavities
    Kohji Nakazawa
    Department of Chemical Processes and Environments, Faculty of Environmental Engineering, The University of Kitakyushu, 1 1 Hibikino, Wakamatsu ku, Kitakyushu, Fukuoka 808 0135, Japan
    J Biomater Sci Polym Ed 17:859-73. 2006
    ..The spheroid microarray technique appears to be promising in the development of cell chips and microbioreactors...
  86. ncbi Cofabrication of electromagnets and microfluidic systems in poly(dimethylsiloxane)
    Adam C Siegel
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, MA 02138, USA
    Angew Chem Int Ed Engl 45:6877-82. 2006
  87. ncbi Characterization of polydimethylsiloxane (PDMS) properties for biomedical micro/nanosystems
    Alvaro Mata
    Department of Chemical and Biomedical Engineering, Cleveland State University, Cleveland, OH, 44115
    Biomed Microdevices 7:281-93. 2005
    ..Oxygen plasma treatment decreased the contact angle of PDMS2 from 109 degrees to 60 degrees. Exposure to tissue culture media resulted in increased PDMS surface element concentrations of nitrogen and oxygen...
  88. ncbi Microfluidic alignment of collagen fibers for in vitro cell culture
    Philip Lee
    Biomolecular Nanotechnology Center, Berkeley Sensor and Actuator Center, Department of Bioengineering, University of California, Berkeley, CA, USA
    Biomed Microdevices 8:35-41. 2006
    ..The use of artificially aligned collagen gels could be applied to the study of cell movement, signaling, growth, and differentiation...
  89. ncbi A hybrid poly(dimethylsiloxane) microsystem for on-chip whole blood filtration optimized for steroid screening
    Sara Thorslund
    Department of Engineering Sciences, Angstrom Laboratory, Uppsala University, Box 534, SE 751 21 Uppsala, Sweden
    Biomed Microdevices 8:73-9. 2006
    ..Surface oxidation was sufficient to make the plasma filtrate flow through the membrane filter and the channel system by capillary force alone and thus no external pumping source was needed...
  90. ncbi Poly(dimethyl siloxane)-based protein chip for simultaneous detection of multiple samples: use of glycidyl methacrylate photopolymer for site-specific protein immobilization
    Kyoung Hwan Park
    Department of Chemical and Biomolecular Engineering, Korea Institute of Science and Technology, 373 1 Guseong dong, Yuseong Gu, Daejeon, Republic of Korea
    Biosens Bioelectron 22:613-20. 2006
    ..Final chip was assembled by connecting separated sample injection channels using a connector mold. The viability of this strategy was successfully demonstrated by simultaneous detection of two different antigen-antibody interactions...
  91. ncbi Reversible thermosensitive glue for retinal implants
    Murat Tunc
    Doheny Eye Institute, University of Southern California, Los Angeles, USA
    Retina 27:938-42. 2007
    ..To determine in vitro effects of a plasma polymerized N-isopropyl acrylamide (pNIPAM) coating for thermally controllable adhesion to retinal tissue...
  92. ncbi Soft material-based microculture system having air permeable cover sheet for the protoplast culture of Nicotiana tabacum
    Jong Il Ju
    Department of Biomedical Engineering, Korea University, Anam dong Seongbuk Gu, Seoul 136 701, South Korea
    Bioprocess Biosyst Eng 29:163-8. 2006
    ..In addition, protoplasts were cultured inside the culture chambers covered with the cover glass and the PDMS sheet, respectively, and the microcolonies were formed well inside the PDMS covered chamber after 10 days...
  93. ncbi Meso-patterning of thin polymer films by controlled dewetting: from nano-droplet arrays to membranes
    Rabibrata Mukherjee
    Department of Chemical Engineering, Indian Institute of Technology, Kanpur 208016, India
    J Nanosci Nanotechnol 7:2069-75. 2007
    ..The thickness of the film and the kinetics of dewetting are the other important parameters that govern the morphology of the resulting structures...
  94. ncbi Is cell culture stressful? Effects of degradable and nondegradable culture surfaces on U937 cell function
    Loren A Matheson
    University of Ottawa, Ottawa, ON, Canada
    Biotechniques 42:744, 746-50. 2007
    ....
  95. pmc The stability of radio-frequency plasma-treated polydimethylsiloxane surfaces
    I Jane Chen
    Department of Biomedical Engineering, 330 Engineering Technology, The University of Memphis, Memphis, TN 38152, USA
    Langmuir 23:3118-22. 2007
    ..The correlation between the FTIR-ATR spectral information and the contact angle data supports this interpretation...
  96. ncbi An organic-inorganic hybrid scaffold for the culture of HepG2 cells in a bioreactor
    Ken Kataoka
    Graduate School of Medicine and Dentistry, Department of Cell Biology, Okayama University, Okayama 700 8558, Japan
    Biomaterials 26:2509-16. 2005
    ..The present results indicate that PDMS-TEOS may be a promising scaffold for developing such functional culture methods...
  97. ncbi Novel transparent poly(silazane) derived solvent-resistant, bio-compatible microchannels and substrates: application in microsystem technology
    Amit Asthana
    Department of Fine Chemical Engineering and Chemistry, College of Engineering, Chungnam National University, Yoseong Gu, Daejeon 305 764, Republic of Korea
    Lab Chip 6:1200-4. 2006
    ..The hydrophobic nature of the cured polymer was best utilized for direct patterning of protein by nonspecific binding...
  98. ncbi Locking retentive attachment for an implant-retained auricular prosthesis
    James C Lemon
    Department of Head and Neck Surgery, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030, USA
    J Prosthet Dent 87:336-8. 2002
    ..This article describes the use of the Slant-Lock retention system with an implant-retained auricular prosthesis...
  99. ncbi Micropatterned surfaces prepared using a liquid crystal projector-modified photopolymerization device and microfluidics
    Kazuyoshi Itoga
    Institute of Advanced Biomedical Engineering and Science, Tokyo Women s Medical University, CREST JST, Kawada cho 8 1, Shinjuku ku, Tokyo 162 8666, Japan
    J Biomed Mater Res A 69:391-7. 2004
    ..This technique should prove useful for inexpensive, rapid prototyping of surface micropatterns from polymer materials...
  100. ncbi Stability of plasma-treated silicone rubber and its influence on the interfacial aspects of blood compatibility
    R L Williams
    Department of Clinical Engineering, University of Liverpool, Duncan Building, Daulby Street, Liverpool L69 3GA, UK
    Biomaterials 25:4659-73. 2004
    ..It was demonstrated that the O(2) and Ar plasma treatments reduced the performance of the silicone but the N(2) and NH(3) treatments had a significantly beneficial effect on the activation of the coagulation cascade...
  101. ncbi Detection of tethered biocide moiety segregation to silicone surface using sum frequency generation vibrational spectroscopy
    Shuji Ye
    Department of Chemistry and Applied Physics Program, University of Michigan, Ann Arbor, Michigan 48109, USA
    Langmuir 24:9686-94. 2008
    ..This research showed that SFG can aid in the development of coatings for controlling biofouling by elucidating the chemical structure of the coating surface...

Research Grants69

  1. Advanced Nitric Oxide Release Bactericidal Urinary Catheters
    Mark E Meyerhoff; Fiscal Year: 2013
    ....
  2. Biomarkers of Fusarium biofilm formation in vitro and in vivo
    PRANAB KUMAR MUKHERJEE; Fiscal Year: 2012
    ..Aim II. Use a molecular approach to (a) construct isogenic mutant strains of Fusarium lacking GAPDH, and (b) determine the effect of targeted gene disruption and overexpression on Fusarium biofilms. ..
  3. Human Pluripotent Stem Cell Differentiation with Defined O2 & Protein Engagement
    ROBERT SAMUEL LANGER; Fiscal Year: 2010
    ..For example, this can lead to ways to grow functioning heart muscle cells that can be used to treat heart disease. ..
  4. BIOGENESIS AND INHIBITION OF BIOFILM-ASSOCIATED BACTERIAL AMYLOID
    Scott J Hultgren; Fiscal Year: 2013
    ..This work will provide key insights into processes necessary for the formation of medically important biofilms and will serve as a model to better understand amyloid plaques important in neurodegenerative disorders. ..
  5. Micro-patterned surfaces for reducing the risk of catheter-associated UTI
    SHRAVANTHI REDDY; Fiscal Year: 2012
    ....
  6. Tissue Engineered Aortic Heart Valves: Scaffolds and Stem Cells
    DAN TEODOR SIMIONESCU; Fiscal Year: 2013
    ..This tissue engineered device has the potential to adapt and remodel with the patient, and thus will have a global impact by treating cardiovascular diseases in adults and children. ..
  7. Temporal and spatial expression of regulators affecting Escherichia coli biofilm
    BIRGIT MAGDALENE PRUESS; Fiscal Year: 2012
    ..This will be done in wild type bacteria and a selection of the mutants. The qualitative data will be related back to the environmental screening experiment by quantifying biofilms from the confocal microscopy images. ..
  8. Vaginal Ring for Preventing Bacterial Vaginosis
    THOMAS RAY MOENCH; Fiscal Year: 2010
    ..The ring will likely be useful for women with frequent episodes of symptomatic BV, and especially useful for preventing BV during pregnancy. ) ..
  9. Safety of Non-Medicated Intravaginal Rings for Microbicide Delivery
    Marla J Keller; Fiscal Year: 2010
    ..The planning grant will address critical knowledge gaps by proposing a trial that includes both clinical and laboratory assessments of ring safety. Results could significantly impact the future direction of microbicide ring development. ..
  10. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY G SAKHRANI; Fiscal Year: 2013
    ..The proposed TriboGlide(R) system will be the first silicone-free system for glass prefilled syringes that overcomes the problems of lubricant migration and drug contamination. ..
  11. Baby bottles that release no chemicals having estrogenic activity
    STUART YANIGER; Fiscal Year: 2012
    ..In Phase I, PPi will confirm preliminary data that that it is feasible to develop EA-Free silicones to manufacture EA-Free nipples for baby bottles...
  12. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..This research should provide new means of measuring and regulating tissue oxygen tensions and tissue oxygen availability in heart attack, stroke, cancer chemotherapy, and trauma...
  13. Stem Cell Based Soft Tissue Reconstruction
    Jeremy J Mao; Fiscal Year: 2010
    ..An interdisciplinary team of biomedical engineers, biologists, biomaterial scientists, imaging scientists and surgical consultants have been assembled to meet the challenges of realizing our goals. ..
  14. A novel anti-scar peptide for cutaneous wound repair
    Chia Soo; Fiscal Year: 2013
    ..To this day, there exist no FDA approved drugs for prevention of scar recurrence. This Phase I SBIR proposal focuses on optimizing the treatment regimen for F06-C40 and proving its safety and efficacy. ..
  15. Development of a Biomimetic Vitreous Substitute
    Nathan Ravi; Fiscal Year: 2013
    ..Upon subsequent exposure to oxygen, the thiol groups in the two components will form disulfide cross-links, resulting in a permanent hydrogel capable of providing osmotic pressure to tamponade the retina. ..
  16. Intraoperative Near-Infrared Fluorescence Imaging
    John V Frangioni; Fiscal Year: 2013
    ..Finally, we propose to intensify clinical translation activities during the second award period, including first-in-human trials of the engineering and chemistry innovations that arise from this BRP. ..
  17. High throughput cell migration assay amenable to high content imaging
    TIMOTHY GEORGE BURLAND; Fiscal Year: 2012
    ..abstract_text> ..
  18. Development of Experimental and Computational Models for Traumatic Aortic Rupture
    Kurosh Darvish; Fiscal Year: 2009
    ..The finite element model will be used as a tool to conduct a parametric study to identify the loading conditions with higher risk of TAR and to analyze the injury mitigation strategies. ..
  19. A perfluorocarbon-based culture device for beta cell biology applications (Phase
    Camillo Ricordi; Fiscal Year: 2013
    ..Success in these studies will also provide proof of principle of the superiority of our oxygen enhancing technology for many other cell culture applications. ..
  20. Cationic Steroidal Antimicrobial-13 for Use as an Orthopedic Device Coating
    Kristofer D Sinclair; Fiscal Year: 2012
    ....
  21. High throughput cell migration assay amenable to high content imaging
    KEREN HULKOWER; Fiscal Year: 2010
    ....
  22. Inhibition of Biofilms on Tympanostomy Tubes
    Ted W Reid; Fiscal Year: 2010
    ..Based upon our findings that a covalent selenium coating will block biofilm formation on tympanostomy tubes, we propose testing selenium-coated tympanostomy tubes for their ability to inhibit tube occlusion and otorrhea. ..
  23. Regulation of Mechano-Induced TGFb1 Activation and Myofibroblast Differentiation
    Yong Zhou; Fiscal Year: 2010
    ..The proposed studies will explore the molecular mechanisms involved in the pathogenesis of lung fibrosis. Our goal is to develop novel therapeutic interventions for IPF treatment. ..
  24. Design, construction, and evaluation of implants for vocal fold alteration and re
    Luc Mongeau; Fiscal Year: 2012
    ..The issues of bonding between implants and native tissue will be examined using atomic force microscopy. ..
  25. Development of a Novel Composite Surgical Mesh
    David J Vachon; Fiscal Year: 2012
    ....
  26. The Urethral Sleeve Sensor_A Novel Method of Measuring Urethral Pressure
    CHARLES WILLIAM NAGER; Fiscal Year: 2012
    ..The impact of this study is that we may demonstrate and validate the first physiologic measurement tool of incontinence cure for both research studies and clinical usage. ..
  27. Adjustable balloon implant for medialization thyroplasty
    Matthew R Hoffman; Fiscal Year: 2012
    ..This proposal describes three basic science experiments designed to improve implant shape and insertion method to enhance its clinical utility. ..
  28. Multi-electrode Arrays with Non-hermetic Encapsulation for Neural Prostheses
    Stuart F Cogan; Fiscal Year: 2010
    ..These arrays will benefit patients with spinal cord injury, stroke, blindness and other diseases or disorders requiring electrical stimulation for treatment. ..
  29. An Enabling Technology for Improving Engraftment of Implanted Materials and Cells
    Michael J Yost; Fiscal Year: 2013
    ..It is our aim to develop an enabling technology that promotes scar-free healing after surgery of implanted biological and synthetic materials in the human body. ..
  30. Multicomponent Intervention to Reduce Sexual Risk and Substance Use
    Jeffrey T Parsons; Fiscal Year: 2013
    ....
  31. Prevention of Bacterial Biofilms on CSF Shunts through the Incorporation of Novel
    Eva Garland; Fiscal Year: 2011
    ..A new strategy for reducing or eliminating these infections would result in substantial increase in quality of life for the hundreds of thousands of people living with hydrocephalus in the United States. ..
  32. An intravaginal ring for real-time evaluation of adherence to topical vagina
    Thomas J Smith; Fiscal Year: 2013
    ..The adherence-monitoring technology developed here may be extended to other pod-IVR delivery devices (i.e. microbicide combinations) and other IVR platforms. ..
  33. Visualization of shear stress-induced endothelial cell signaling.
    Eugene Tkachenko; Fiscal Year: 2009
    ..These exploratory studies have the potential to enable the facile analysis of flow-mediated signaling in living endothelial cells. ..
  34. Antibiotic-binding Peptides for Biofilm Prevention on Ventriculoperitoneal Shunts
    HANNE GRON; Fiscal Year: 2010
    ..Completion of this Phase II program will result in a peptide-based antibiotic delivery prototype, ready for Phase III studies to continue moving this IFBM into development. ..
  35. Episcleral Chemotherapy as Salvage Therapy for Eyes with Retinoblastoma
    RICARDO A CARVALHO; Fiscal Year: 2010
    ....
  36. Novel High Density Interconnects for Flexible Neural Prostheses
    HELMUT ECKHARDT; Fiscal Year: 2012
    ....
  37. Injection Practices and HIV Risk Behavior among Transgendered Persons in Pue
    SHEILLA LEE RODRIGUEZ; Fiscal Year: 2012
    ..This will help guide future pilot interventions aimed at reducing HIV infection and high-risk drug use and injection practices in this vulnerable group. ..
  38. Biodegradable Field-Effect Transitors for Electronically Active Scaffolds
    CHRISTOPHER JOHN BETTINGER; Fiscal Year: 2010
    ..The scaffolds could be implanted, serve their specified function over a pre-programmed time scale, and would then eventually become resorbed within the body. ..
  39. ORAL CONTROLLED-RELEASE DELIVERY SYSTEMS
    H Rawls; Fiscal Year: 1991
    ..The results will be used to characterize the rates and durations of release achievable by this system, and will provide the basis for later development of other controlled-release systems...
  40. RT Inhibitor CSIC and Entry Inhibitor Retrocyclin RC101 as Microbicides
    Phalguni Gupta; Fiscal Year: 2012
    ..Therefore, the proposed study will provide novel strategies to develop microbicides for the prevention of HIV-1 transmission and their sequelae for women. ..
  41. PICC VERSUS SUBCLAVIAN LINES IN TPN DELIVERY
    Joel Weinstock; Fiscal Year: 1999
    ..This study will serve as a basis for developing larger cooperative clinical trial groups to further investigate issues in nutritional delivery to hospitalized patients. ..
  42. Artificial Cornea Using New Biomaterials
    MAX MAGINNESS; Fiscal Year: 2009
    ..Use of well proven biocompatible materials (silicones) with appropriate optical and mechanical properties for the entire artificial cornea device structure...
  43. Hybrid retinal prosthesis utilizing bioadhesives for reversible attachment
    HELMUT ECKHARDT; Fiscal Year: 2010
    ....
  44. Long Term Extracorporeal Oxygenating Device
    JEAN MONTOYA; Fiscal Year: 2013
    ..This research will enable the development of a compact oxygenator with greatly improved gas transfer, lower priming volume, improved flow dynamics, lower blood resistance, and lower cost. ..
  45. Processing of Materials for Improved Biocompatibility
    Michael Matthews; Fiscal Year: 2004
    ..abstract_text> ..
  46. An Outcome Study of Rheumatoid Hand Arthroplasty
    Kevin C Chung; Fiscal Year: 2013
    ..This study seeks to define the optimal treatment of this RA hand condition and to provide evidence in guiding hand surgery treatment for this prevalent disease. ..
  47. Delayed Hydrogel Tissue Expander
    Yourong Fu; Fiscal Year: 2007
    ..This technology will reduce the incidence of morbidity associated with this surgery thus promoting general public health. [unreadable] [unreadable] [unreadable]..
  48. RAI CONDOM: Feasibility & Acceptability Study, Phase 1 Pilot Clinical Research
    DANIEL RESNIC; Fiscal Year: 2010
    ..Its user-friendly design is intended to introduce a pleasurable, more acceptable, receptive- partner-controlled barrier and to encourage its use. ..
  49. DEVELOPMENT OF AN IMPLANTABLE EMG MICRO-TELEMETER
    DAVID EDELL; Fiscal Year: 2006
    ..During this time final regulatory approval will be sought and marketii begiaon a limited basis. ..
  50. Silicone-free glass pre-filled syringe system for Biological Drugs.
    VINAY SAKHRANI; Fiscal Year: 2009
    ..The proposed TriboGlide system will be the first silicone oil-free system for glass prefilled syringes that overcomes the problems of lubricant migration and drug contamination. ..
  51. Compact Debridement and Treatment Delivery Device for Dermal Wound Care
    ANDREA WESSER; Fiscal Year: 2011
    ..At least 9000 recorded cases of US nursing home abuse was related to improper wound care during a study performed between 1999 and 2001. ..
  52. Vaginal ring formulation of tenofovir microbicide
    Thomas J Smith; Fiscal Year: 2010
    ..The broad long term goal of this project is to empower women to protect themselves from HIV infection through the development of an improved microbicide based on the sustained release drug delivery of the antiretroviral agent tenofovir. ..
  53. Characterizing TiO2 as an Anti-Inflammatory Biomaterial
    John Frangos; Fiscal Year: 2005
    ..Our long-term goal is to extend this knowledge to develop new biocompatible materials with superior mechanical and material properties than titanium. ..
  54. Tissue Engineering by a Non-Biologic Skin Substitute
    WILLIAM SEARE; Fiscal Year: 2005
    ....
  55. Wireless Multichannel Electrocorticogram Recording for Epilepsy Monitoring
    Stuart Cogan; Fiscal Year: 2009
    ..The wireless arrays will benefit patients with intractable epilepsy whose seizures are not well-controlled by medication. ..
  56. A DRUG RELEASING URINARY CATHETER
    Robert Whalen; Fiscal Year: 2000
    ..The new urinary catheter has the potential to reduce hospital costs associated with the management of catheter associated infections. ..
  57. Catechol-functionalized Coatings for Medical Devices
    KRISTIN S TATON; Fiscal Year: 2013
    ....
  58. Coupling Strategies for Middle Ear Protheses
    ANN GRONDA; Fiscal Year: 2003
    ..Although directed primarily at implantable hearing aids, project fitidings are also applicable to any ossicular chain reconstruction prosthesis. ..
  59. LCP Nerve Cuff with Telemetry for Prosthetic Sensation
    RONALD RISO; Fiscal Year: 2004
    ..PHASE II work will involve in-vivo tests in animal models followed by evaluation in clinical trials with amputee volunteers and with spinal cord injury and stroke patients. ..
  60. Origami MALE CONDOM-3: Feasibility &Acceptability Study, Phase 1 Clinical Resear
    DANIEL RESNIC; Fiscal Year: 2012
    ..A Couples Acceptability &Performance (CAP) Study to investigate the acceptability, and performance of the "preferred" prototype among 36 couples. ..
  61. Effects of Noise on Newborns < 1000g Birthweight
    Robert Lasky; Fiscal Year: 2007
    ..The research team consists of respected investigators skilled in assessing NICU noise, evaluating infant responses, and performing randomized trials addressing important short and long term outcomes of ELBW infants. ..
  62. CARDIOPULMONARY GEOMETRY AND BLOOD FLOW
    Carol Lucas; Fiscal Year: 1991
    ..implied: 1) how do the geometries of the right ventricle and major pulmonary arteries change from birth to adult life? and 2) how do geometric variations resulting from normal aging and/or individual variability affect flow dynamics?..
  63. ENZYME-COATED URINARY PROSTHESES TO PREVENT ENCRUSTATION
    STEPHEN BARTELMEZ; Fiscal Year: 2004
    ....
  64. Adjustable Injectable Intraocular Lens
    Shiao Chang; Fiscal Year: 2004
    ..abstract_text> ..
  65. Disposable Valved Intraurethral Catheter Feasibility
    Phillip Davis; Fiscal Year: 2005
    ..No inventions currently available or in development combine the utility and health-care cost benefits of Urovalve's invention. ..
  66. Enhanced Oxygenation of Bioreactors
    Stuart Nemser; Fiscal Year: 2003
    ..Economic evaluation will also be done to determine overall value of membrane oxygenators. ..
  67. Circumferential Neuropathic Foot Protector System (CNEP)
    Jeffrey Jensen; Fiscal Year: 2001
    ....
  68. Silver coatings to combat catheter associated infections
    Bruce Gibbins; Fiscal Year: 2006
    ..Successful commercialization would significantly improve catheter design and contribute to a reduction in health care expenditure for nosocomial infections. [unreadable] [unreadable]..
  69. A NEW FINGER JOINT PROSTHESIS
    Robert Whalen; Fiscal Year: 1990
    ..A quantitative comparison of device fixation and tissue capsule structure will then be possible...