Summary: Substances produced from the reaction between acids and bases; compounds consisting of a metal (positive) and nonmetal (negative) radical. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Recent advances in engineering plant tolerance to abiotic stress: achievements and limitations
    Basia Vinocur
    The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture and the Otto Warburg Center for Agricultural Biotechnology, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Curr Opin Biotechnol 16:123-32. 2005
  2. ncbi Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors
    Celine E Riera
    Nestle Research Center, P O Box 44, CH 1000 Lausanne 26, Switzerland
    Am J Physiol Regul Integr Comp Physiol 293:R626-34. 2007
  3. ncbi Transgenic expression of MYB15 confers enhanced sensitivity to abscisic acid and improved drought tolerance in Arabidopsis thaliana
    Zhenhua Ding
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 36:17-29. 2009
  4. ncbi Contribution of surface salt bridges to protein stability: guidelines for protein engineering
    George I Makhatadze
    Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, 500 UniversityDrive, Hershey, PA 17033 2390, USA
    J Mol Biol 327:1135-48. 2003
  5. ncbi Effects of salts on internal DNA pressure and mechanical properties of phage capsids
    Alex Evilevitch
    Department of Physics, Carnegie Mellon University, PA 15213, USA
    J Mol Biol 405:18-23. 2011
  6. ncbi Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
  7. pmc Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products
    Michael H Baumann
    Medicinal Chemistry Section of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 38:552-62. 2013
  8. ncbi Seasonal flows on warm Martian slopes
    Alfred S McEwen
    Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA
    Science 333:740-3. 2011
  9. ncbi Contribution of surface salt bridges to protein stability
    P Strop
    Biochemistry Option, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:1251-5. 2000
  10. pmc A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana
    T Mizoguchi
    Laboratory of Plant Molecular Biology, Institute of Physical and Chemical Research RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
    Proc Natl Acad Sci U S A 93:765-9. 1996

Detail Information

Publications342 found, 100 shown here

  1. ncbi Recent advances in engineering plant tolerance to abiotic stress: achievements and limitations
    Basia Vinocur
    The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture and the Otto Warburg Center for Agricultural Biotechnology, The Hebrew University of Jerusalem, PO Box 12, Rehovot 76100, Israel
    Curr Opin Biotechnol 16:123-32. 2005
    ..Unraveling additional stress-associated gene resources, from both crop plants and highly salt- and drought-tolerant model plants, will enable future molecular dissection of salt-tolerance mechanisms in important crop plants...
  2. ncbi Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors
    Celine E Riera
    Nestle Research Center, P O Box 44, CH 1000 Lausanne 26, Switzerland
    Am J Physiol Regul Integr Comp Physiol 293:R626-34. 2007
    ..We also found that TRPV1 receptors are activated by CuSO(4), ZnSO(4), and FeSO(4), three salts known to produce a metallic taste sensation...
  3. ncbi Transgenic expression of MYB15 confers enhanced sensitivity to abscisic acid and improved drought tolerance in Arabidopsis thaliana
    Zhenhua Ding
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China
    J Genet Genomics 36:17-29. 2009
  4. ncbi Contribution of surface salt bridges to protein stability: guidelines for protein engineering
    George I Makhatadze
    Department of Biochemistry and Molecular Biology, College of Medicine, Penn State University, 500 UniversityDrive, Hershey, PA 17033 2390, USA
    J Mol Biol 327:1135-48. 2003
    ..Implications of these findings for engineering proteins with enhanced thermostability are discussed...
  5. ncbi Effects of salts on internal DNA pressure and mechanical properties of phage capsids
    Alex Evilevitch
    Department of Physics, Carnegie Mellon University, PA 15213, USA
    J Mol Biol 405:18-23. 2011
    ..The model also predicts the stiffness of other DNA-filled capsids, which we confirm using bacteriophage ϕ29 and herpes simplex virus type 1 particles...
  6. ncbi Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels
    Celine E Riera
    Nestle Research Center, Vers chez les Blanc, CH 1000 Lausanne, Switzerland
    J Neurosci 29:2654-62. 2009
    Complex tasting divalent salts (CTDS) are present in our daily diet, contributing to multiple poorly understood taste sensations...
  7. pmc Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products
    Michael H Baumann
    Medicinal Chemistry Section of the Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA
    Neuropsychopharmacology 38:552-62. 2013
    The abuse of psychoactive 'bath salts' containing cathinones such as 3,4-methylenedioxypyrovalerone (MDPV) is a growing public health concern, yet little is known about their pharmacology...
  8. ncbi Seasonal flows on warm Martian slopes
    Alfred S McEwen
    Lunar and Planetary Laboratory, University of Arizona, Tucson, AZ 85721, USA
    Science 333:740-3. 2011
    ..Liquid brines near the surface might explain this activity, but the exact mechanism and source of water are not understood...
  9. ncbi Contribution of surface salt bridges to protein stability
    P Strop
    Biochemistry Option, California Institute of Technology, Pasadena, California 91125, USA
    Biochemistry 39:1251-5. 2000
    ..5 kcal mol(-)(1). The entropic cost of making a surface salt bridge involving the protein's backbone is reduced, since the backbone has already been immobilized upon protein folding...
  10. pmc A gene encoding a mitogen-activated protein kinase kinase kinase is induced simultaneously with genes for a mitogen-activated protein kinase and an S6 ribosomal protein kinase by touch, cold, and water stress in Arabidopsis thaliana
    T Mizoguchi
    Laboratory of Plant Molecular Biology, Institute of Physical and Chemical Research RIKEN, Tsukuba Life Science Center, Ibaraki, Japan
    Proc Natl Acad Sci U S A 93:765-9. 1996
  11. pmc SOS2 promotes salt tolerance in part by interacting with the vacuolar H+-ATPase and upregulating its transport activity
    Giorgia Batelli
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, California 92521, USA
    Mol Cell Biol 27:7781-90. 2007
    ..Our results suggest that regulation of V-ATPase activity is an additional key function of SOS2 in coordinating changes in ion transport during salt stress and in promoting salt tolerance...
  12. ncbi Quaternary ammonium salts and their antimicrobial potential: targets or nonspecific interactions?
    Maximilian Tischer
    Institute of Pharmacy and Food Chemistry, University of Wurzburg, Wurzburg, Germany
    ChemMedChem 7:22-31. 2012
    ..This review discusses the structure-activity relationships and the modes of action of the various series of (bis)quaternary ammonium compounds...
  13. ncbi Long chain amines and long chain ammonium salts as novel inhibitors of dynamin GTPase activity
    Timothy A Hill
    Advanced Synthetic Materials Group, Chemistry Building, School Environmental and Life Sciences, The University of Newcastle, Callaghan, NSW 2308, Australia
    Bioorg Med Chem Lett 14:3275-8. 2004
    ..However, introduction of a hydrophobic collar proximal to the charged site was beneficial to dynamin GTPase inhibitory action. The most potent compound was myristoyl trimethyl ammonium bromide (MTMAB, IC(50) 3.15 microM)...
  14. ncbi Control of xyloglucan endotransglucosylase activity by salts and anionic polymers
    Takumi Takeda
    The Edinburgh Cell Wall Group, ICMB, The University of Edinburgh, Daniel Rutherford Building, The King s Buildings, EH9 3JH, UK
    Planta 219:722-32. 2004
    ..Activity was restored (promoted up to 40-fold) by any of a wide variety of inorganic and organic salts. Optimum concentrations for Na+, K+ and NH4+ salts were typically approximately 300 mM...
  15. ncbi Perfusion culture of hepatocytes within galactose-derivatized biodegradable poly(lactide-co-glycolide) scaffolds prepared by gas foaming of effervescent salts
    Tae Gwan Park
    Korea Advanced Institute of Science and Technology, Department of Biological Sciences, 373 1 Yusong gu, Kusong Dong, Taejon, 305 701, Korea
    J Biomed Mater Res 59:127-35. 2002
    ..of highly porous biodegradable poly(D,L-lactic-co-glycolic acid) scaffolds prepared by gas foaming of effervescent salts. Rat hepatocytes seeded within the scaffolds were cultivated by using a continuous flow and perfusion reactor ..
  16. pmc Natural variation in Arabidopsis thaliana revealed a genetic network controlling germination under salt stress
    Navot Galpaz
    Department of Plant Breeding and Genetics, Max Planck Institute for Plant Breeding Research, Koln, Germany
    PLoS ONE 5:e15198. 2010
    ..Our data highlights the presence of a genetic network which consists of four interacting QTLs and controls germination under limiting environmental conditions...
  17. ncbi Malsegregation as a possible mechanism of aneuploidy induction by metal salts in MRC-5 human cells
    A I Seoane
    Centro de Investigaciones en Genética Básica y Aplicada, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina
    Environ Mol Mutagen 40:200-6. 2002
    ..The aim of the present study was to provide evidence that the aneugenic effect of some metal salts is the consequence of malsegregation at anaphase and that it is not caused by nondisjunction mechanisms...
  18. pmc Improved matrix-assisted laser desorption/ionization mass spectrometric detection of glycosaminoglycan disaccharides as cesium salts
    Tatiana N Laremore
    Department of Chemistry and Chemical Biology, Rensselaer Polytechnic Institute, Troy, NY 12180, USA
    Rapid Commun Mass Spectrom 21:1315-20. 2007
    ..The lithium, sodium, potassium, rubidium, and cesium salts of SOS were analyzed by UV-MALDI-time-of-flight (TOF)MS using an ionic liquid matrix, bis-1,1,3,3-..
  19. pmc Fast and high-yield microreactor syntheses of ortho-substituted [(18)F]fluoroarenes from reactions of [(18)F]fluoride ion with diaryliodonium salts
    Joong Hyun Chun
    PET Radiopharmaceutical Sciences Section, Molecular Imaging Branch, National Institute of Mental Health, Rm B3 C346A, Building 10, 10 Center Drive, Bethesda, Maryland 20892 1003, USA
    J Org Chem 75:3332-8. 2010
    ..7 min) with diaryliodonium salts. The microreactor provided a very convenient means for running sequential reactions rapidly with small amounts of ..
  20. pmc Structural basis for the enhanced thermal stability of alcohol dehydrogenase mutants from the mesophilic bacterium Clostridium beijerinckii: contribution of salt bridging
    Oren Bogin
    Department of Organic Chemistry, The Weizmann Institute of Science, Rehovot 76100, Israel
    Protein Sci 11:2561-74. 2002
  21. ncbi Media composition: salts and osmolality
    Jay M Baltz
    Department of Obstetrics and Gynecology, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada
    Methods Mol Biol 912:61-80. 2012
    The main components of embryo culture media are salts, which dissociate into their component inorganic ions in aqueous solution...
  22. ncbi Sensitive electrospray mass spectrometry analysis of one-bead-one-compound peptide libraries labeled by quaternary ammonium salts
    Remigiusz Bąchor
    University of Wrocław, ul F Joliot Curie 14, 50 383 Wrocław, Poland
    Mol Divers 16:613-8. 2012
    ..The application of an efficient method of peptide derivatization by quaternary ammonium salts (QAS) formation increases ionization efficiency and reduces the detection limit, allowing analysis of trace ..
  23. ncbi Role of the Hofmeister series in the formation of ionic-liquid-based aqueous biphasic systems
    Shahla Shahriari
    Departamento de Quimica, CICECO, Universidade de Aveiro, 3810 193 Aveiro, Portugal
    J Phys Chem B 116:7252-8. 2012
    ..of ionic liquids is their ability to form aqueous biphasic systems (ABSs) when combined with inorganic or organic salts in aqueous media...
  24. ncbi Microbial colonization of naturally black olives during fermentation and associated biochemical activities in the cover brine
    G J E Nychas
    Department of Food Science and Technology, Agricultural University of Athens, Athens, Greece
    Lett Appl Microbiol 34:173-7. 2002
  25. pmc Enhanced expression of vacuolar H+-ATPase subunit E in the roots is associated with the adaptation of Broussonetia papyrifera to salt stress
    Min Zhang
    Jiangsu Academy of Forestry, Dongshanqiao, Jiangning, Nanjing, Jiangsu, China
    PLoS ONE 7:e48183. 2012
    ..Altogether, our results suggest an essential role for V-H(+)-ATPase subunit E in the response of plants to salinity stress...
  26. ncbi Synthesis and structure of selected quaternary N-(1,4-anhydro-5-deoxy-2,3-O-isopropylidene-D,L-ribitol-5-yl)ammonium salts
    Eugenia Skorupa
    Department of Chemistry, University of Gdansk, Sobieskiego 18, PL 80 952 Gdansk, Poland
    Carbohydr Res 339:2355-62. 2004
    ..syntheses have been developed for quaternary N-(1,4-anhydro-5-deoxy-2,3-O-isopropylidene-D,L-ribitol-5-yl)ammonium salts derived from five aromatic amines, pyridine, 2-methylpyridine, 3-carbamoylpyridine, 4-(N,N-dimethylamino)pyridine, ..
  27. ncbi Antisettlement activity of synthetic analogues of polymeric 3-alkylpyridinium salts isolated from the sponge Reniera sarai
    Marco Faimali
    CNR Istituto di Scienze Marine ISMAR Sezione Tecnologie Marine, Genova, Italy
    Biofouling 21:49-57. 2005
    Based on the high, non-toxic and reversible antifouling activity of the polymeric 3-alkylpyridinium salts isolated from the sponge Reniera sarai, the anti-settlement activity and toxicity of a series of synthetic analogues has been ..
  28. ncbi Effect of deicing salts on urban soils and health status of roadside trees in the Opole region
    Izabela Czerniawska-Kusza
    Department of Land Protection, University of Opole, Oleska 22, 45 052 Opole, Poland
    Environ Toxicol 19:296-301. 2004
    This article reports on a study whose aim was to evaluate the impact of snow removal salts on urban soil properties and the health of roadside trees...
  29. ncbi Salt shield: intracellular salts provide cellular protection against ionizing radiation in the halophilic archaeon, Halobacterium salinarum NRC-1
    A Kish
    Department of Cell Biology and Molecular Genetics, University of Maryland, College Park, MD 20742, USA
    Environ Microbiol 11:1066-78. 2009
    ..The finding that not only Mn/Fe but also the presence of halides can decrease the oxidative damage to DNA and proteins emphasizes the significance of the intracellular milieu in determining microbial radiation resistance...
  30. ncbi Three novel, structurally unique spirocyclic alkaloids from the halotolerant B-17 fungal strain of Aspergillus variecolor
    Wen Liang Wang
    Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China
    Chem Biodivers 4:2913-9. 2007
    ..All compounds were shown to exhibit weak cytotoxic and antioxidant activities...
  31. ncbi Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana
    Teruaki Taji
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 29:417-26. 2002
  32. ncbi When do water-insoluble polyion-surfactant ion complex salts "redissolve" by added excess surfactant?
    Salomé dos Santos
    Division of Physical Chemistry, Department of Chemistry, Lund University, P O Box 124, SE 22100 Lund, Sweden
    Langmuir 27:592-603. 2011
    ..A number of stoichiometric polyion-surfactant ion "complex salts" were synthesized and they consisted of akyltrimethylammonium surfactant ions of two different alkyl chain lengths ..
  33. ncbi Bartter syndromes and other salt-losing tubulopathies
    Robert Kleta
    Section on Human Biochemical Genetics, Medical Genetics Branch, National Human Genome Research Institute, Bethesda, MD 20892, USA
    Nephron Physiol 104:p73-80. 2006
    ..We summarize recent findings in the field in the context of human diseases and a pathophysiologic basis for their treatment...
  34. pmc A rigidifying salt-bridge favors the activity of thermophilic enzyme at high temperatures at the expense of low-temperature activity
    Sonia Y Lam
    School of Life Sciences, Centre for Protein Science and Crystallography, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China
    PLoS Biol 9:e1001027. 2011
    ..Here we employed a thermophilic acylphosphatase from Pyrococcus horikoshii and its homologous mesophilic acylphosphatase from human as a model to study how local rigidity of an active-site residue affects the enzymatic activity...
  35. ncbi Direct interaction of a divergent CaM isoform and the transcription factor, MYB2, enhances salt tolerance in arabidopsis
    Jae Hyuk Yoo
    Division of Applied Life Science BK21 program, Plant Molecular Biology and Biotechnology Research Center, and Environmental Biotechnology National Core Research Center, Gyeongsang National University, Jinju 660 701, Korea
    J Biol Chem 280:3697-706. 2005
    ..Therefore, we suggest that a specific CaM isoform mediates salt-induced Ca2+ signaling through the activation of an MYB transcriptional activator, thereby resulting in salt tolerance in plants...
  36. ncbi Ion pairs and the thermotolerance of proteins from hyperthermophiles: a "traffic rule" for hot roads
    A Karshikoff
    Centre for Structural Biochemistry, Karolinska Institutet, Novum, 14157 Huddinge, Sweden
    Trends Biochem Sci 26:550-6. 2001
    ..This feature is less evident in proteins from thermophilic organisms and is absent from mesophile-derived proteins...
  37. pmc Experimental constraints on quaternary structure in Alzheimer's beta-amyloid fibrils
    Aneta T Petkova
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Biochemistry 45:498-512. 2006
    ..These models apply to Abeta(1-40) fibrils grown with gentle agitation. We also present evidence for different internal quaternary contacts in Abeta(1-40) fibrils grown without agitation, which are morphologically distinct...
  38. pmc A DEAD-box protein alone promotes group II intron splicing and reverse splicing by acting as an RNA chaperone
    Sabine Mohr
    Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas, Austin, TX 78712, USA
    Proc Natl Acad Sci U S A 103:3569-74. 2006
    ..More generally, our results provide additional evidence for the widespread role of RNA chaperones in folding cellular RNAs...
  39. ncbi Dominant role of prostaglandin E2 EP4 receptor in furosemide-induced salt-losing tubulopathy: a model for hyperprostaglandin E syndrome/antenatal Bartter syndrome
    Rolf M Nusing
    Institute of Clinical Pharmacology, Johann Wolfgang Goethe University, Theodor Stern Kai 7, Frankfurt 60590, Germany
    J Am Soc Nephrol 16:2354-62. 2005
    ..In summary, these findings demonstrate that the EP4 receptor mediates PGE2-induced renin secretion and that EP1, EP3, and EP4 receptors all contribute to enhanced PGE2-mediated salt and water excretion in the HPS/aBS model...
  40. ncbi Electrostatic and hydrophobic interactions play a major role in the stability and refolding of halophilic proteins
    Tsutomu Arakawa
    Alliance Protein Laboratories, 3957 Corte Cancion, Thousand Oaks, CA 91360, USA
    Protein Pept Lett 11:125-32. 2004
    In general, halophilic proteins are stable only in the presence of salts at high concentrations...
  41. ncbi Salt bridges in the hyperthermophilic protein Ssh10b are resilient to temperature increases
    Meng Ge
    Key Laboratory of Bioinformatics, Ministry of Education, Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, China
    J Biol Chem 283:31690-6. 2008
    ..Implications of this finding are useful for engineering proteins with enhanced thermostability...
  42. ncbi The enhancement of xylose monomer and xylotriose degradation by inorganic salts in aqueous solutions at 180 degrees C
    Chaogang Liu
    Thayer School of Engineering, Dartmouth College, Hanover, NH 03755, USA
    Carbohydr Res 341:2550-6. 2006
    The inorganic salts KCl, NaCl, CaCl2, MgCl2, and FeCl3, and especially the latter, significantly increased xylose monomer and xylotriose degradation in water heated to 180 degrees C with unaccountable losses of xylose amounting to as ..
  43. ncbi Addition of Al and Fe salts during treatment of paper mill effluents to improve activated sludge settlement characteristics
    V Agridiotis
    Department of Civil Engineering, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK
    Bioresour Technol 98:2926-34. 2007
    Metal salts, ferrous sulphate and aluminium chloride, were added to laboratory-scale activated sludge plant treating paper mill effluents to investigate the effect on settlement characteristics...
  44. ncbi Synthesis of aryl sulfones via L-proline-promoted CuI-catalyzed coupling reaction of aryl halides with sulfinic acid salts
    Wei Zhu
    Department of Chemistry, Fudan University, Shanghai 200433, China
    J Org Chem 70:2696-700. 2005
    reaction: see text] The CuI/L-proline sodium salt catalyzed coupling reaction of aryl halides with sulfinic acid salts readily occurs at 80-95 degrees C in DMSO to give the corresponding aryl sulfones in good to excellent yields...
  45. ncbi Synthesis of phospholipid-conjugated bile salts and interaction of bile salt-coated liposomes with cultured hepatocytes
    G Putz
    University Medical Clinic Freiburg, D 79106 Freiburg, Germany
    J Lipid Res 46:2325-38. 2005
    To examine the possibility of targeting liposomes to hepatocytes via bile salts, the bile salt lithocholyltaurine was covalently linked to a phospholipid...
  46. ncbi Morphology of actin assemblies in response to polycation and salts
    Hyuck Joon Kwon
    Graduate School of Science, Hokkaido University, Sapporo 060 0810, Japan, and SORST, JST, Sapporo, 060 0810, Japan
    Biomacromolecules 6:3005-9. 2005
    ..Our results indicate that the semiflexible polyelectrolyte nature of F-actins is important for controlling the morphology and growth of actin architectures in cells...
  47. pmc Observations of aminium salts in atmospheric nanoparticles and possible climatic implications
    James N Smith
    Atmospheric Chemistry Division, National Center for Atmospheric Research, 1850 Table Mesa Dr, Boulder, CO 80305, USA
    Proc Natl Acad Sci U S A 107:6634-9. 2010
    ..TDCIMS measurements of these aminium salts showed that the protonated amines underwent minimal decomposition during analysis, with detection sensitivities ..
  48. pmc Electrolytic reduction: modification of proteins occurring in isoelectric focusing electrophoresis and in electrolytic reactions in the presence of high salts
    Der Yen Lee
    Graduate Institute of Biochemical Sciences, College of Life Science, National Taiwan University, P O Box 23 106, Taipei 106, Taiwan
    Anal Chem 81:3957-64. 2009
    Artifacts in two-dimensional electrophoresis (2-DE) caused by the presence of salts in isoelectric focusing (IEF) have been previously described as a result of increasing conductivity and inducing electroosmosis...
  49. ncbi Halophilic enzymes: proteins with a grain of salt
    M Mevarech
    Department of Molecular Microbiology and Biotechnology, George S Wise Faculty of Life Sciences, Tel Aviv University, Israel
    Biophys Chem 86:155-64. 2000
  50. ncbi Facile synthesis of spiro[indoline-3,3'-pyrrolo[1,2-a]quinolines] and spiro[indoline-3,1'-pyrrolo[2,1-a]isoquinolines] via 1,3-dipolar cycloaddition reactions of heteroaromatic ammonium salts with 3-phenacylideneoxindoles
    Lei Wu
    College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China
    Org Biomol Chem 10:9452-63. 2012
  51. pmc Design, synthesis, and application of tartaric acid derived N-spiro quaternary ammonium salts as chiral phase-transfer catalysts
    Mario Waser
    Institute of Organic Chemistry, Johannes Kepler University Linz, Altenbergerstraße 69, 4040 Linz, Austria
    Org Biomol Chem 10:251-4. 2012
    A novel class of tartaric acid-derived N-spiro quaternary ammonium salts was synthesised starting from known TADDOLs...
  52. ncbi Effects of nisin, EDTA and salts of organic acids on Listeria monocytogenes, Salmonella and native microflora on fresh vacuum packaged shrimps stored at 4 °C
    M N Wan Norhana
    School of Agricultural and Food Sciences, University of Queensland, St Lucia, Queensland 4072, Australia
    Food Microbiol 31:43-50. 2012
    ..99 log CFU g⁻¹ respectively, as compared to the control. Dipping in organic acids solutions followed by vacuum packaging and chilled storage can help reduce L. monocytogenes and native microflora, but not Salmonella, on fresh shrimps...
  53. ncbi Hofmeister phenomena in nonaqueous media: the solubility of electrolytes in ethylene carbonate
    Niccolò Peruzzi
    Department of Chemistry and CSGI, University of Florence, 50019 Sesto Fiorentino Firenze, Italy
    J Phys Chem B 116:14398-405. 2012
    The solubility of some potassium salts (KF, KCl, KBr, KI, KNO(3), KClO(4), KSCN, and KSeCN) in ethylene carbonate (EC) was determined at different temperatures with an inductively coupled plasma atomic emission spectrometer...
  54. pmc Sodic soil properties and sunflower growth as affected by byproducts of flue gas desulfurization
    Jinman Wang
    College of Land Science and Technology of China University of Geosciences, Handian District, Beijing, People s Republic of China
    PLoS ONE 7:e52437. 2012
    ..rate and yield of the sunflower increased, and the exchangeable sodium percentage (ESP), pH and total dissolved salts (TDS) in the soils decreased after the byproducts were applied...
  55. ncbi Milk composition, milk fatty acid profile, digestion, and ruminal fermentation in dairy cows fed whole flaxseed and calcium salts of flaxseed oil
    C Cortes
    Dairy and Swine Research and Development Centre, Agriculture and Agri Food Canada, STN Lennoxville, Sherbrooke, QC J1M 1Z3, Canada
    J Dairy Sci 93:3146-57. 2010
    ..randomly assigned to a 4 x 4 Latin square design to determine the effects of feeding whole flaxseed and calcium salts of flaxseed oil on dry matter intake, digestibility, ruminal fermentation, milk production and composition, and ..
  56. ncbi Cell signaling under salt, water and cold stresses
    J K Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Curr Opin Plant Biol 4:401-6. 2001
    ..Molecular analysis revealed a transcriptional cascade in cold-regulated gene expression...
  57. pmc Improved arene fluorination methodology for I(III) salts
    Bijia Wang
    Department of Chemistry and Nebraska Center for Materials and Nanoscience, University of Nebraska, Lincoln, Nebraska 68588 0304, USA
    Org Lett 12:3352-5. 2010
    The use of low polarity aromatic solvents (benzene or toluene) and/or the removal of inorganic salts results in dramatically improved yields of fluorinated arenes from diaryliodonium salts...
  58. ncbi 2:1 cocrystals of homochiral and achiral amino acid zwitterions with Li+ salts: water-stable zeolitic and diamondoid metal-organic materials
    Tien Teng Ong
    Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, CHE205, Tampa, Florida 33620, USA
    J Am Chem Soc 133:9224-7. 2011
    Eight 2:1 cocrystals of amino acid zwitterions and Li(+) salts were crystallized from hot water to afford cationic networks based on tetrahedral lithium cations: square grids, an ABW topology net, and diamondoid nets.
  59. ncbi The use of inorganic salts to improve the dissolution characteristics of tablets containing Soluplus®-based solid dispersions
    Justin R Hughey
    Division of Pharmaceutics, The University of Texas at Austin, 1 University Station A1920, Austin, TX 78712, United States
    Eur J Pharm Sci 48:758-66. 2013
    ..The objective of this study was to investigate the ability of inorganic salts to improve the dissolution rate of carbamazepine (CBZ) from tablets containing a high loading of a Soluplus®-..
  60. ncbi Arylation of lithium sulfinates with diaryliodonium salts: a direct and versatile access to arylsulfones
    Natalie Umierski
    Department of Organic Chemistry and Chemical Biology, Goethe University Frankfurt, Frankfurt am Main, Germany
    Org Lett 15:4972-5. 2013
    ..Based on this method, a practical protocol for the direct transformation of (hetero)arenes and (hetero)aromatic halides into diarylsulfones was developed. ..
  61. ncbi Effect of molecular size and particle shape on the terahertz absorption of a homologous series of tetraalkylammonium salts
    Andrew D Burnett
    School of Electronic and Electrical Engineering, University of Leeds, Leeds, UK
    Anal Chem 85:7926-34. 2013
  62. ncbi The expressions of Delta 9-, Delta 12-desaturases and an elongase by the extremely halotolerant black yeast Hortaea werneckii are salt dependent
    Cene Gostincar
    Department of Biology, Biotechnical Faculty, University of Ljubljana, Ljubljana, Slovenia
    FEMS Yeast Res 9:247-56. 2009
    ..Transcriptional responses to hyperosmotic and hypo-osmotic shock show substantial differences between cells exposed to osmotic shock and cells adapted to an osmotically stressful environment...
  63. ncbi Culture-independent study of the diversity of microbial populations in brines during fermentation of naturally-fermented Aloreña green table olives
    Hikmate Abriouel
    Area de Microbiologia, Departamento de Ciencias de la Salud, Facultad de Ciencias Experimentales, Universidad de Jaen, 23071 Jaen, Spain
    Int J Food Microbiol 144:487-96. 2011
    ..together with some halophilic archaea and a more selected yeast population (P. manshurica/P. galeiformis). The present study illustrates the complexity of the microbial populations in naturally-fermented Aloreña table olives...
  64. ncbi Structure--activity relationship and preclinical evaluation of carbon-11-labeled ammonium salts as PET--myocardial perfusion imaging agents
    Ohad Ilovich
    Cyclotron Radiochemistry Unit Nuclear Medicine Department, Hadassah Hebrew University Hospital, Jerusalem, 91120, Israel
    Mol Imaging Biol 14:625-36. 2012
    ..Due to the limited availability of suitable positron emission tomography (PET) tracers, the majority of myocardial perfusion imaging (MPI) scans is performed using SPECT rather than PET...
  65. pmc Role of the WNK-activated SPAK kinase in regulating blood pressure
    Fatema H Rafiqi
    University of Dundee, Scotland, UK
    EMBO Mol Med 2:63-75. 2010
    ..See accompanying Closeup by Maria Castañeda-Bueno and Gerald Gamba (DOI 10.1002/emmm.200900059)...
  66. pmc Generation of oxidant response to copper and iron nanoparticles and salts: Stimulation by ascorbate
    Robert H Rice
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Chem Biol Interact 181:359-65. 2009
    ..Soluble salts of copper and iron exhibited the same contrast in activities as the respective combustion-generated particles...
  67. ncbi Drug salts and solubilization: modeling the influence of cyclodextrins on oral absorption
    Ece Dilber Gamsiz
    Department of Chemical Engineering, Northeastern University, 342 Snell Engineering Center, Boston, MA 02115, USA
    Ann Biomed Eng 39:455-68. 2011
    ..Modeling enabled examination of which physical and chemical properties result in oral absorption enhancement or decrement for drug salt administered as a physical mixture with CD...
  68. ncbi Eliminating inhibition of enzymatic hydrolysis by lignosulfonate in unwashed sulfite-pretreated aspen using metal salts
    Hao Liu
    State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China
    Bioresour Technol 101:9120-7. 2010
    ..These results demonstrate that applying divalent metal salts eliminates the need for washing, thereby saving considerable process water and cost for production of chemicals ..
  69. ncbi Fiberoptic infrared spectroscopy: a novel tool for the analysis of urine and urinary salts in situ and in real time
    Shmuel Cytron
    Department of Urology, Barzilai Medical Center, Ashkelon, Israel
    Urology 61:231-5. 2003
    To use infrared fiberoptic spectroscopy for the analysis of urinary salts in real time and with no sample processing; and to assess the practical role of this method for the quantitative measurement of the composition of urine and for ..
  70. ncbi Catalytic conversion of dihydroxyacetone to lactic acid using metal salts in water
    Carolus B Rasrendra
    Chemical Engineering Department, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands
    ChemSusChem 4:768-77. 2011
    We herein present a study on the application of homogeneous catalysts in the form of metal salts on the conversion of trioses, such as dihydroxyacetone (DHA), and glyceraldehyde (GLY) to lactic acid (LA) in water...
  71. ncbi Preparation of macroporous biodegradable PLGA scaffolds for cell attachment with the use of mixed salts as porogen additives
    Hong Ru Lin
    Department of Applied Chemistry, Chia Nan University of Pharmacy and Science, Tainan, Taiwan 717
    J Biomed Mater Res 63:271-9. 2002
    ..In addition, the polymer/salts/solvent mixture can be easily handled and molded into scaffolds of any specific shape-for example, thin sheet, ..
  72. ncbi Field amplified injection in the presence of salts for capillary electrophoresis
    Z K Shihabi
    Pathology Department, Wake Forest University Baptist Medical Center, Winston Salem, NC 27157, USA
    J Chromatogr A 853:3-9. 1999
    b>Salts in the sample are detrimental to the stacking by the field-amplified injection. However, physiological samples often contain salts at levels of about 1% which can diminish the peak height or cause band spreading instead of stacking...
  73. ncbi Role of dissolved salts in thermophoresis of DNA: lattice-Boltzmann-based simulations
    Audrey Hammack
    Department of Chemistry, University of Texas at Tyler, Tyler, Texas, USA
    Phys Rev E Stat Nonlin Soft Matter Phys 83:031915. 2011
    ..Brownian dynamics simulation to investigate the dependence of DNA thermophoresis on its interaction with dissolved salts. We find the thermal diffusion coefficient D{T} depends on the molecule size, in contrast with previous ..
  74. ncbi Modification of anomalous swelling in multilamellar vesicles induced by alkali halide salts
    S S Korreman
    Department of Mathematics and Physics (IMFUFA, Roskilde University, Denmark
    Eur Biophys J 30:121-8. 2001
    By use of small-angle X-ray scattering it is shown that addition of alkali halide salts in small amounts (0-200 mM) shifts the repeat spacing in multilamellar DC13PC vesicles and alters the anomalous swelling behaviour close to the main ..
  75. ncbi Physicochemical characterization of creatine N-methylguanidinium salts
    Brandon T Gufford
    Department of Pharmaceutical Sciences, College of Pharmacy, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska, USA
    J Diet Suppl 7:240-52. 2010
    ..As a zwitterionic compound, creatine can form salts at the N-methyl guanidinium or carboxylic acid functional groups...
  76. ncbi Unexpected reactivity of Au25(SCH2CH2Ph)18 nanoclusters with salts
    Manzhou Zhu
    Department of Chemistry, Anhui University, Hefei, Anhui 230026, PR China
    Nanoscale 3:1703-7. 2011
    ..of the chemical reactivity of thiolate-protected [Au(25)(SCH(2)CH(2)Ph)(18)](0) nanoclusters with two types of salts, including tetraoctylammonium halide (TOAX) and NaX...
  77. ncbi Some magnesium salts and a mixture of magnesium and calcium salts accelerate skin barrier recovery
    M Denda
    Shiseido Research Center 2, 2 12 1 Fukuura, Kanazwa ku, Yokohama, 236 8643, Japan
    Arch Dermatol Res 291:560-3. 1999
    The effects of four different magnesium salts on the cutaneous barrier recovery rate after barrier disruption were evaluated...
  78. ncbi Salt tolerance in soybean
    Tsui Hung Phang
    Department of Biology, Chinese University of Hong Kong, Shatin, Hong Kong, China
    J Integr Plant Biol 50:1196-212. 2008
    ..In this review, we tried to integrate the relevant works on soybean and proposes a working model to describe its salt stress responses at the molecular level...
  79. ncbi The correlation of RNase A enzymatic activity with the changes in the distance between Nepsilon2-His12 and N delta1-His119 upon addition of stabilizing and destabilizing salts
    A A Moosavi-Movahedi
    Institute of Biochemistry and Biophysics, University of Tehran, Iran
    Protein J 25:117-25. 2006
    The effect of stabilizing and destabilizing salts on the catalytic behavior of ribonuclease A (RNase A) was investigated at pH 7.5 and 25 degrees C, using spectrophotometric, viscometric and molecular dynamic methods...
  80. ncbi Effect of salts on the stability and folding of staphylococcal nuclease
    C Nishimura
    Department of Chemistry and Biochemistry, University of California, Santa Cruz, California 95064, USA
    Biochemistry 40:2113-28. 2001
    ..nuclease (SNase) at neutral pH are significantly perturbed by the presence of moderate to high concentrations of salts. Very substantial increases in stability toward thermal and urea denaturation were observed; for example, 0...
  81. ncbi MALDI imaging mass spectrometry of lipids by adding lithium salts to the matrix solution
    Christopher D Cerruti
    Centre de Recherche de Gif, Institut de Chimie des Substances Naturelles, CNRS, Gif sur Yvette, France
    Anal Bioanal Chem 401:75-87. 2011
    ..A new sample preparation method is proposed, involving the use of lithium salts in the matrix solution in order to simplify the mass spectra with only lithium-cationized molecules instead of a ..
  82. ncbi Exploration of potential prodrug approach of the bis-thiazolium salts T3 and T4 for orally delivered antimalarials
    Sergio A Caldarelli
    Institut des Biomolecules Max Mousseron, UMR CNRS, Universite Montpellier, France
    Bioorg Med Chem Lett 20:3953-6. 2010
    ..and biological evaluation of a series of 37 compounds as precursors of potent antimalarial bis-thiazolium salts (T3 and T4)...
  83. ncbi Analytical microscopy observations of rat enterocytes after oral administration of soluble salts of lanthanides, actinides and elements of group III-A of the periodic chart
    C Floren
    Service de Gastro Enterologie, Hĵpital St Antoine, Paris, France
    Cell Mol Biol (Noisy-le-grand) 47:419-25. 2001
    ..barrier of nine elements (three of the group III-A, four lanthanides and two actinides), absorbed as soluble salts, has been studied by two microanalytical methods: electron probe X-ray micro analysis (EPMA) and secondary ion ..
  84. ncbi Study of ion-paired iridium complexes (soft salts) and their application in organic light emitting diodes
    Chao Wu
    Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    J Am Chem Soc 132:3133-9. 2010
    Three Ir-based materials were synthesized through metathesis reaction between halide and alkali metal salts of two cationic and three anionic Ir complexes, respectively...
  85. ncbi Synthesis and antimicrobial activity of some pyridinium salts
    Vildan Alptüzün
    Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ege University, 35100, Bornova, Izmir, Turkey
    Molecules 14:5203-15. 2009
  86. pmc Halophilic enzyme activation induced by salts
    Gabriel Ortega
    Structural Biology Unit, CIC bioGUNE, Bizkaia Technology Park, Building 800, 48160 Derio, Spain
    Sci Rep 1:6. 2011
    ..This model has been successfully applied to reengineer Hv LigN into an enzyme that is catalytically active in the presence of NaCl...
  87. ncbi Effects of high concentration of salts on the esterase activity and structure of a kiwifruit peptidase, actinidain
    Koichi Morimoto
    Department of Biotechnological Science, Kinki University, Nishimitani, Kinokawa, Wakayama 649 6493
    J Biochem 139:1065-71. 2006
    Effects of salts on the activity and stability of actinidain were examined. With increasing salt concentration up to 0...
  88. ncbi Uptake of atmospheric mercury by deionized water and aqueous solutions of inorganic salts at acidic, neutral and alkaline pH
    D T Waite
    Environment Canada, Regina, SK
    Chemosphere 49:341-51. 2002
    ..The low pH solutions of various salt concentrations and the high pH solutions of high salt concentrations tested in this study generally showed a greater tendency to absorb and retain atmospheric Hg0 than those at a pH closer to neutral...
  89. ncbi Nanomechanical recognition of N-methylammonium salts
    Marco Dionisio
    Department of Organic and Industrial Chemistry, University of Parma, and INSTM, UdR Parma, Parco Area delle Scienze 17A, 43124 Parma, Italy
    J Am Chem Soc 134:2392-8. 2012
    ..we demonstrate how the energy of the molecular recognition between a supramolecular host and small alkylammonium salts can be harnessed to perform a nanomechanical task in a univocal way...
  90. ncbi The influence of condition on permeation of Ca(II) ions from solutions of selected calcium's salts through model membrane
    Barbara Dolińska
    Biochefa Pharmaceutical Research and Production Plant, Kasztanowa 3, Sosnowiec, Poland
    Biol Trace Elem Res 140:95-102. 2011
    ..Process was traced depending on the concentration of the appropriate calcium's salts (1, 2.5, and 5 mmol/l) and pH value of acceptor environment (1.3, 6.2, and 7...
  91. ncbi Effect of salts addition on hydrogen production by C. acetobutylicum
    H Alshiyab
    School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600 UKM Bangi, Selangor, Malaysia
    Pak J Biol Sci 11:2193-200. 2008
    The objective of this study is to investigate the effect of salts addition to fermentation medium on hydrogen production, under anaerobic batch culture system...
  92. ncbi Effects of salts on protein-surface interactions: applications for column chromatography
    Kouhei Tsumoto
    Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Kashiwanoha, Kashiwa 277 8562, Japan
    J Pharm Sci 96:1677-90. 2007
    ..Most column chromatographies require salts, whether inorganic or organic, for binding, elution or simply better recovery and resolution...
  93. ncbi The polyamine spermine protects against high salt stress in Arabidopsis thaliana
    Koji Yamaguchi
    Graduate School of Life Sciences, Tohoku University, Sendai, Miyagi 980 8577, Japan
    FEBS Lett 580:6783-8. 2006
    ..The data suggest that the absence of spermine causes an imbalance in Ca(2+) homeostasis in the mutant plant. Based on the data obtained, we propose a model for a role of spermine in high salt stress responses...
  94. ncbi Electrophysiological responses to salts from antennal chaetoid taste sensilla of the ground beetle Pterostichus aethiops
    Enno Merivee
    Estonian Agricultural University, Institute of Plant Protection, 64 Kreutzwaldi Street, 51014 Tartu, Estonia
    J Insect Physiol 50:1001-13. 2004
    ..1797) (Coleoptera, Carabidae) respond to salts, the three sensory cells, A-, B- and C-cells, producing action potentials that are distinguished by differences in ..
  95. ncbi Systematic study of hydration patterns of phosphoric(V) acid and its mono-, di-, and tripotassium salts in aqueous solution
    Maciej Smiechowski
    Department of Physical Chemistry, Chemical Faculty, Gdansk University of Technology, Narutowicza 11 12, 80 233 Gdansk, Poland
    J Phys Chem B 113:7650-61. 2009
    ..Further interpretation of the energetic and structural properties of hydrating water is enabled by calculating intermolecular interaction energy of water and probability distributions for interatomic oxygen-oxygen distance...
  96. ncbi Atypical effect of salts on the thermodynamic stability of human prion protein
    Adrian C Apetri
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    J Biol Chem 278:22187-92. 2003
    ..Previous studies indicate that salts promote conformational conversion of the recombinant prion protein into a PrPSc-like form...
  97. ncbi Antimicrobial activities and cellular responses to natural silicate clays and derivatives modified by cationic alkylamine salts
    Shan Hui Hsu
    Institute of Polymer Science and Engineering, National Taiwan University, Taipei 10617 Taiwan, Republic of China
    ACS Appl Mater Interfaces 1:2556-64. 2009
    ..The derivatives of NSP (NSP-S) which were modified by C18-fatty amine salts via ionic exchange association exhibited the highest antibacterial activity in the aqueous state among all clays...
  98. ncbi Relationship between apatite-forming ability and mechanical properties of bioactive PMMA-based bone cement modified with calcium salts and alkoxysilane
    Atsushi Sugino
    Graduate School of Engineering, Nagoya University, Furo cho, Chikusa ku, Nagoya 464 8603, Japan
    J Mater Sci Mater Med 19:1399-405. 2008
    ..revealed that modification using gamma-methacryloxypropyltrimethoxysilane (MPS) and water-soluble calcium salts such as calcium acetate and calcium hydroxide was effective for providing the PMMA-based bone cement with apatite-..
  99. ncbi Thermostable variants constructed via the structure-guided consensus method also show increased stability in salts solutions and homogeneous aqueous-organic media
    E Vazquez-Figueroa
    School of Chemical and Biomolecular Engineering, Parker H Petit Institute for Bioengineering and Bioscience, Atlanta, GA 30332 0363, USA
    Protein Eng Des Sel 21:673-80. 2008
    ..method also showed improved stability in solutions with high concentrations of kosmotropic and chaotropic salts and water-miscible organic solvents...
  100. ncbi Haloarchaeal diversity in 23, 121 and 419 MYA salts
    J S Park
    Canadian Institute for Advanced Research, Program in Integrated Microbial Diversity, and Department of Biology, Dalhousie University, Halifax, Canada
    Geobiology 7:515-23. 2009
    ..The DNA demonstrates that unknown haloarchaea and the Halobacterium were key components in ancient hypersaline environments. Halorubrum and Haloarcula appear to be a dominant group in relatively modern hypersaline habitats...
  101. ncbi Mesomorphic imidazolium salts: new vectors for efficient siRNA transfection
    William Dobbs
    Institut de Physique et Chimie des Materiaux de Strasbourg, UMR 7504, CNRS Universite de Strasbourg, BP 43, 23 rue du Loess, F 67034 Strasbourg Cedex 2, France
    J Am Chem Soc 131:13338-46. 2009
    ..The two series of salts possess a rich thermotropic mesomorphism, chain-length dependent...

Research Grants71

  1. Photodynamic Therapy of Localized Infections
    Michael R Hamblin; Fiscal Year: 2013
    ..Aim 1 will explore a finding that the clinically approved PS, methylene blue and related penothiazinium salts could have their antimicrobial PDT effect potentiated by addition of simple ions like iodide...
    John R Grider; Fiscal Year: 2013
    ..of BDNF will be determined in response to physiological stimuli (mucosal stroking, free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or ..
  3. A Ribozyme Rescue Strategy for Dry Age-Related Macular Degeneration
    John M Sullivan; Fiscal Year: 2013
    ..autofluorescence under blue light excitation due to the dominant presence of toxic bis-retinoid pyridinium salts (A2E) and retinaldehyde dimers (RetDi)...
  4. Novel Phosphate Binder: Effects on Hyperphosphatemia, Vascular Calcification & Bo
    DEANNA J contact NELSON; Fiscal Year: 2010
    ..use a translational animal model to verify these preliminary results and determine whether this combination of salts concomitantly decreases the rate and progression of vascular calcification, attenuates adynamic bone disorder, and ..
  5. Diet and Gastrointestinal Cancer Risk in African Americans and Rural Africans
    STEPHEN JD O'KEEFE; Fiscal Year: 2012
    ..producing bacteria in AAs which are stimulated by high animal fat diets to produce carcinogenic secondary bile salts. In contrast, a high resistant starch diet stimulates mucosal-protective Lactobacillus species were, indeed, found ..
    Benjamin L Shneider; Fiscal Year: 2012
    ..bile acid transporter (ASBT) is the major carrier protein involved in intestinal reclamation of bile salts. Inactivating mutations in humans and mice lead to pathologic bile acid induced diarrhea, while partial inhibition ..
  7. A novel and powerful C. elegans behavioral model of addiction
    Eric A Engleman; Fiscal Year: 2013
    ..In addition, we have recently reported that C. elegans display a conditioned preference for cues (salts) that had previously been paired with cocaine or methamphetamine which is analogous to findings in mammalian ..
  8. Structural Biology of the Apical Bile Acid Transporter.
    Peter W Swaan; Fiscal Year: 2012
    ..The apical sodium-dependent bile acid transporter (ASBT) plays a key role in the enterohepatic recycling of bile salts, cholesterol homeostasis, and serves as a molecular target for hypercholesterolemic agents and pharmaceutical ..
    JOHN GRIDER; Fiscal Year: 2009
    ..of BDNF will be determined in response to physiological stimuli (mucosal stroking, free fatty acids, and bile salts), to neurotransmitters (CGRP and SP), and to paracrine agents (5-HT and endocannabinoids) known to mediate or ..
  10. Molecular Analysis of NeoAdjuvant Platinum in Triple Negative Breast Cancer
    MARK DANIEL contact PEGRAM; Fiscal Year: 2010
    ..5%) patients had histopathologic confirmation of TNBC. All patients received neoadjuvant platinum salts. Pathologic complete response (pCR) was strictly defined as no residual invasive disease in breast and axilla...
  11. Preclinical development of a novel antibacterial for Clostridium difficile diseas
    George E Wright; Fiscal Year: 2012
    ..Compound 359E and analogs are tertiary amines, readily form water soluble salts, and are highly effective against Cdiff in vitro and in vivo...
  12. Novel transgenic reporter/deleter allele for Type I taste cells
    Sue Kinnamon; Fiscal Year: 2013
    ..As such, they represent the first step in the process by which nutritious substances, such as Na+ salts, sugars, and amino acids can be detected and distinguished from harmful substances, such as acids and toxic bitter ..
    M Thomas Record; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Biochemically-significant small molecules (Hofmeister salts, osmolytes, denaturants, collectively referred to as solutes) exert often large, specific effects on fundamental biological processes ..
  14. Radiolabled MAO-B Substrates for Imaging
    Michael R Kilbourn; Fiscal Year: 2012
    ..4-Thiophenyl-1,2,3,6-dihydropyridines are oxidized to the corresponding non-toxic dihydropyridinium salts;the 4-carbamoyl-1,2,3,6- dihydropyridines are oxidized to the corresponding dihydropyridinium salts that ..
  15. Transdermal delivery of 2-Arachidonoyl glycerol (2-AG) for the treatment of arthr
    Audra L Stinchcomb; Fiscal Year: 2012
    ..If prodrugs fail to improve the flux of 2-AG, microneedle assisted delivery of salts of 2-AG or its prodrugs will be carried out...
  16. Role of Acid in the Development of Barrett's Esophagus
    Stuart Jon Spechler; Fiscal Year: 2013
    ..The aims of this study are (1) to elucidate the mechanisms whereby acid and bile salts activate HIF-2?, (2) to determine the role of HIF-2? in acid and bile salt-induced expression of pro-inflammatory ..
  17. Biocompatibility of Implantable Renal Replacement Devices
    Shuvo Roy; Fiscal Year: 2013
    ..blood will be filtered in the hemofilter under circulatory system pressure to remove uremic toxins, salts, small solutes, and water...
  18. Immunotherapeutic Potential of Modified Lipooligosaccharides and Lipid A's
    Robert K Ernst; Fiscal Year: 2013
    ..Until recently alum salts, which require repeated applications and tend to be skewed towards T helper TH2-based immunity (humoral) rather ..
  19. Taste representations in the Drosophila brain
    KRISTIN E SCOTT; Fiscal Year: 2012
    ..receptors mediate detection of sugars, amino acids, and bitter compounds, whereas ion channels detect salts and acids...
  20. Understanding the role of bile as a mechanism for improved glucose homeostasis fo
    APRIL DAWN STRADER; Fiscal Year: 2010 the resolution of type-II diabetes is the exposure of the lower intestine to higher concentrations of bile salts. As mentioned above, the interposed ileum is exposed to high concentrations of biliopancreatic secretions...
  21. 2010 Angiotensin Gordon Research Conference
    Kathy K Griendling; Fiscal Year: 2010
    ..HEALTH RELEVANCE: We produce a hormone called angiotensin, which raises blood pressure and retains fluids and salts in our bodies...
  22. Novel molecular therapeutics for cystic fibrosis
    David E Sterner; Fiscal Year: 2012
    ..The cause is the ?F508 mutation of the CF (CFTR), which aberrantly regulates levels of salts inside and outside cells, leading to the disease pathologies...
  23. Cytoskeletal linking proteins in renal epithelial cell function
    R Brian Doctor; Fiscal Year: 2012
    ..RELEVANCE: The broad goal of the proposed studies is to better understand how the body regulates the movement of salts and water in and out of the body...
  24. DNA and RNA Stability in Glycine Betaine, TMAO, and Urea Solutions: Correlating S
    JEFFREY JAMES contact SCHWINEFUS; Fiscal Year: 2010
    ..provided by applicant): Cellular biochemical reactions involving nucleic acids occur in aqueous solutions of salts, cosolutes, and biopolymers, such as proteins...
    Mira Edgerton; Fiscal Year: 2013
    ..cationic peptides is disruption of initial binding of Hst 5 to the yeast cell wall surface by extracellular salts. Objectives of this proposal are design of salt-insensitive peptides which are efficiently transported into the ..
  26. Reasons for poor durability of resin-dentin bonds
    David H Pashley; Fiscal Year: 2013
    ..We noted that CHX contains biguanide groups that form acidic addition salts with a cationic charge delocated over the five neighboring secondary amine nitrogen atoms of the biguanides...
  27. Rapid Field Test for Iodine Levels in Salt
    Bikas Vaidya; Fiscal Year: 2012
    ..Demonstrate that iodide from iodized salts can be oxidized to iodine using a dried oxidizing agent;ii)...
  28. Hereditary Causes of Nephrolithaisis and Kidney Failure
    DAWN SCHMAUTZ MILLINER; Fiscal Year: 2013
    300 words Four inborn errors of metabolism lead to high concentrations of insoluble mineral salts in the urine and severe, recurrent nephrolithiasis...
    Gary M Mawe; Fiscal Year: 2010
    ..Recent reports suggest that decreased gallbladder motility is caused by elevated cholesterol and hydrophobic salts in the bile, and that ensuing inflammation and impairments in gallbladder emptying lead to stone formation...
  30. Transport and Insertion of Outer Membrane Proteins
    Marcelo C Sousa; Fiscal Year: 2013
    ..that allows the bacteria to survive in hostile environments such as the gut, where the OM resistance to bile salts allows enteric bacteria to thrive...
  31. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    ..of a new class of reactive entities that are uniquely activated by metal cations that form part of the nuclide salts most often used in the synthesis of PET agents (e.g. K18F and K11CN)...
  32. Au/Pt Catalysis in the Synthesis of Elaborate N-Heterocycles: Methodology Develop
    Liming Zhang; Fiscal Year: 2013
    ..Au catalysis has attracted tremendous attention lately due to the exceptional capacities of Au salts/complexes in activating alkynes/allenes/alkenes. Pt catalysts, mostly PtCl2, have shown similar reactivities...
  33. Low Temperature Solid-State NMR Technologies for Protein Structure Determination
    Chad M Rienstra; Fiscal Year: 2013 sparse isotopic labeling patterns and cryoprotection procedures utilizing organic alcohols, glycols and salts. Sensitivity will be improved by reducing T1 relaxation times with paramagnetic relaxation enhancement reagents, ..
    Jianghui Hou; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Kidneys function by initially excreting many salts and small molecules found in the blood, then selectively taking back those that need to be conserved while ..
  35. Nanocrystal delivery to the CNS to improve HIV therapy
    David M Margolis; Fiscal Year: 2013
    ..The history of the use of gold salts in rheumatoid disease suggests that long-term toxicities, if encountered, may be manageable...
  36. Asymmetric Lewis Base Catalysis in Main Group Chemistry
    Scott Eric Denmark; Fiscal Year: 2013
    ..Catalysis of the ligand coupling reaction of iodonium salts is unprecedented and will be investigated for the construction of enantiomerically enriched ?-aryl, ?-alkenyl, ?-..
  37. Investigations of Bacterial Biofilm Proteomes Using Artifical Amino Acids
    NICHOLAS DEWAYNE BALL; Fiscal Year: 2013
    ..Ga3+ salts have recently emerged as effective antibiotic agents against P...
  38. Modulation of Peripheral Gustatory Neurons by Organic Salts and Organic Acids
    JOSEPH MICHAEL BREZA; Fiscal Year: 2011
    ..Today however, many preservatives in the form of organic Na+ salts, with large anions and organic acids are used in processed foods to increase shelf life, maintain color, and ..
  39. Innate Immune Defense against Clostridium Difficile Infection
    Eric G Pamer; Fiscal Year: 2013
    ..We will investigate the role IL22, the arl hydrocarbon receptor and primary and secondary bile salts in TLR-mediated defense against C. difficile infection...
  40. Impact of Lipids On Intestinal Mucus Transport And Structural Properties
    Rebecca L Carrier; Fiscal Year: 2013 food-associated lipids within the mucus layer will be examined using EPR and nitroxide-probe labeled bile salts and lipids, as it is currently not understood whether these structures stay intact within mucus, which could ..
  41. Development of stable and rapidly acting adjuvanted vaccines for biodefense
    ROBERT NEWTON BREY; Fiscal Year: 2013
    ..Most vaccines are formulated in aqueous buffers and suspensions with aluminum salts adjuvants, vaccine immunogens degrade and lose potency (and efficacy)...
  42. Testing Novel Interventions to Protect Workers from Airborne Infections
    Edward A Nardell; Fiscal Year: 2013
    ..The inhaled salt solution is isotonic saline, a prototype for several cationic salts shown to reduce the generation of airborne particles by changing the mechanical properties of the fluid normally ..
  43. Comparative Safety and Effectiveness of Stimulants in Medicaid Youth with ADHD
    Almut G Winterstein; Fiscal Year: 2010
    ..population) between 1999 - 2006 to: (1) evaluate the cardiac risk of stimulants overall, and of mixed amphetamine salts (MAS) versus methylphenidate (MPH) individually, on fatal or severe cardiovascular events;(2) assess whether ..
  44. Non-invasive sampling of DNA markers for pancreatic cancer screening
    Yu Tsueng Liu; Fiscal Year: 2013
    ..However, the hostile environment of the gastrointestinal tract composed of bile salts, DNases, and proteases reduces the chances that pancreatic cancer cells and cancer DNA will survive during the ..
    Gregory Gores; Fiscal Year: 2009
    ..Specifically, our long-term goal is to understand the cellular mechanisms by which bile salts, which accumulate in the liver during cholestasis, modulate hepatocyte apoptosis...
  46. Mephedrone and addiction: clues from animal models
    Scott M Rawls; Fiscal Year: 2013
    ..Mephedrone is a component of a dangerous street drug called psychoactive bath salts (PABS) and hypothesized to have abuse liability, share pharmacological properties with notorious drugs, and ..
  47. Photodegradation Reactions Mono and Dinitro PAHs
    Rafael Arce; Fiscal Year: 2011
    ..produced on adsorbents that mimic the atmospheric particle matter such as inorganic oxides, and sulfate salts, and determine the effect of the physical and chemical properties of the surfaces of these solids (such as ..
  48. Mechanisms of Psychostimulant Abuse
    CLAYTON THOMAS BAUER; Fiscal Year: 2013
    ..illicit MARs such as methylenedioxymethamphetamine (MDMA, "ecstasy") and the cathinone derivatives in "bath salts" function as prevalent and dangerous drugs of abuse without approved clinical uses...
  49. Synthesis of Radiofluorinated PET Imaging Agents
    STEPHEN DIMAGNO; Fiscal Year: 2013
    ..describing the high yield formation of aryl fluorides from the reductive elimination of diaryliodonium fluoride salts. Specific aim 2 is to develop a general synthetic methodology that permits highly functionalized aromatic ..
  50. 2/2 Multicenter trial of combined pharmacotherapy to treat cocaine dependence
    KYLE MATTHEW KAMPMAN; Fiscal Year: 2013
    ..A pilot study (N=81) conducted by our research group found that the combination of mixed amphetamine salts extended-release (MAS-ER) and topiramate was effective for promoting abstinence among cocaine- dependent ..
  51. 1/2-Multicenter Trial of Combined Pharmacotherapy to Treat Cocaine Dependence
    Frances Rudnick Levin; Fiscal Year: 2013
    ..A pilot study (N=81) conducted by our research group found that the combination of mixed amphetamine salts extended-release (MAS-ER) and topiramate was effective for promoting abstinence among cocaine- dependent ..
  52. Water Soluble Antimitotics That Circumvent Rumor Resistance
    Susan L Mooberry; Fiscal Year: 2013
    ..The analogs proposed for optimization of the lead compounds are easily synthesized as water soluble salts. The analogs will be evaluated as inhibitors of tumor cells and tubulin assembly in vitro and active compounds ..
  53. Physiological effects of hyperosmotic vocal fold surface fluid
    Mahalakshmi Sivasankar; Fiscal Year: 2011
    ..These perturbations raise the concentration of salts, proteins, and particulate in the effects of hyperosmotic vocal fold surface fluid on vocal function and mucosal ..
  54. Stimulants and Vascular Events in ADHD
    Mark Olfson; Fiscal Year: 2010
    ..the two most widely prescribed stimulants for youth with attention-deficit/hyperactivity disorder (ADHD), mixed salts of amphetamine (MAS) and methylphenidate (MPH), may increase the risk of stroke, myocardial infarction, and other ..
  55. The Transporter Classification Database (TCDB)
    Milton H Saier; Fiscal Year: 2013
    ..scientific community with systematized information about proteins that catalyze transmembrane transport of salts, nutrients, toxins, drugs and macromolecules...
  56. Synthetic cathinones: a new class of illicit drugs affecting DAT &SERT
    SIDNEY S NEGUS; Fiscal Year: 2013
    ..The infamous and contemporary drug, bath salts, now penetrating our society with cruel effect, is composed of two additional derivatives of the basic [unreadable]..
  57. A new interpretation of solute effects on biological equilibria
    Daryl K Eggers; Fiscal Year: 2013
    ..and entropy values of bulk water will be measured and tabulated for many solutions of interest, including neutral salts, osmolytes, chaotropes, and crowding agents...
  58. Atheroregression via Enhanced Reverse Cholesterol Transport
    Henry J Pownall; Fiscal Year: 2012
    ..methods to show in cells and mice that SOF promotes conversion of macrophage-cholesterol to water-soluble bile salts that enter the intestine for disposal;characterize in mice the changes in response to SOF in the quantity and ..
  59. Somatosensory Factors in Human Taste and Flavor Perception
    Barry G Green; Fiscal Year: 2013
    ..Finally, Aim 4 will measure how temperature influences the taste and chemesthetic sensations of salts and acids with the specific goal of testing the hypothesis that their chemesthetic qualities are evoked primarily ..
  60. Using deep-cavity cavitands to study supramolecular chemistry in water
    Bruce C Gibb; Fiscal Year: 2013
    ..For example, our understanding of the Hofmeister Effect - why some salts (kosmotropes) decrease the solubility of organic solutes whilst others (chaotropes) increase solubility - is ..
  61. An innovative approach to improve the activity of an aluminum-containing adjuvant
    Zhengrong Cui; Fiscal Year: 2013
    ..Aluminum salts, such as aluminum hydroxide, are widely used in various human vaccines...
  62. A Mass Spectrometry Probe for Transient Imaging of In-Solution Biochemistry
    Andrei G Fedorov; Fiscal Year: 2011
    ..This "lab-on-a-tip" will include in-line microdialysis to remove salts and exchange solvent, as well as an integrated tryptic digestion micro-reactor...
    Edward Moore; Fiscal Year: 1990
    Several previous studies have shown that whole bile and/or bile salts enhance absorption of both iron and calcium...
    Theodore Kurtz; Fiscal Year: 1990
    ..If so, "hidden" sources of dietary Na+, i.e. nonchloride sodium salts such as sodium bicarbonate or ascorbate, may not be as important in the pathogenesis of hypertension as has been ..
    Andrew Streitwieser; Fiscal Year: 1999
    ..the reaction is now most often run in non-polar solvents, such as tetrahydrofuran (THF), frequently with lithium salts of carbonyl compounds (lithium enolates)...
  66. Male Subfertility By Ni2+ Poisoning of Ca2+ Channels ?
    Susan Benoff; Fiscal Year: 2001
    Nickel is widely used in steel alloys and as metal plate. Nickel salts are well-recognized as allergens and carcinogens...
    David Cohen; Fiscal Year: 2000
    ..physicochemical and molecular biological experiments to delineate the hepatocellular mechanisms whereby bile salts promote biliary secretion of cholesterol together with highly specific phosphatidylcholines...
  68. Raman spectroscopy probes for assisting stereotactic breast biopsy needle placeme
    Stephen Fulghum; Fiscal Year: 2009
    ..Microcalcifications are small, solid deposits of calcium salts, often associated with cancerous lesions, which strongly absorb x-rays and thus show up as high-contrast shadows ..
  69. The Critical Role of Bile Salts:Gut Protection in Critical Illness
    Eric Strauch; Fiscal Year: 2009
    Our objective is to show that bile salts have significant beneficial effects on the intestinal mucosa, through the activation of the transcription factors c-myc and NF-:B...
  70. Protein Stabilization in Ionic Liquids
    Gloria Elliott; Fiscal Year: 2009
    ..ILs are synthesized from imidazolium-based actions and highly fluorinated anions, ILs can also be formulated from salts, sugars, amino acids, and biomolecules that exist in nature - many of which have already been approved as ..
    Takaaki Aoba; Fiscal Year: 1993
    ..pathological enamel mineralization is to determine: a) the driving force for precipitation of calcium phosphate salts during amelogenesis, b) the cellular role in establishing such a driving force, and c) the possible regulatory ..