Genomes and Genes
Summary: A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes.
Publications229 found, 100 shown here
- Evaluation of effects of prenatal exposure to the cyanide and thiocyanate in wistar ratsAltamir Benedito de Sousa
Research Center for Veterinary Toxicology CEPTOX, Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
Reprod Toxicol 23:568-77. 2007A study was performed at term and at weaning to verify the toxic effects of the prenatal exposure to potassium cyanide (KCN) and potassium thiocyanate (KSCN) in pregnant Wistar rats...
- Cardiovascular responses to chemoreflex activation with potassium cyanide or hypoxic hypoxia in awake ratsRenata C H Barros
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, SP, Brazil
Auton Neurosci 97:110-5. 2002Although intravenous (iv) injection of potassium cyanide (KCN) activates the arterial chemoreflex, it has been questioned whether cytotoxic hypoxia reproduces a physiological stimulus such as hypoxic hypoxia (low inspired O2 tension)...
- Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanideKhanit Suwanborirux
Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
J Nat Prod 66:1441-6. 2003Renieramycins M (1m) and N (1n) were isolated from the Thai sponge Xestospongia sp., pretreated with potassium cyanide in methanolic buffer solution, and their structures and relative stereochemistries were elucidated on the basis of ..
- Hydroxocobalamin for poisoning caused by ingestion of potassium cyanide: a case studyJean Luc Fortin
SAMU 25, CHU J Minjoz, Besancon, France
J Emerg Med 39:320-4. 2010..The case supports the efficacy of hydroxocobalamin for acute cyanide poisoning caused by ingestion of a cyanide salt. No adverse events attributed to hydroxocobalamin were observed...
- Interaction of potassium cyanide with the [Ni-4Fe-5S] active site cluster of CO dehydrogenase from Carboxydothermus hydrogenoformansSeung Wook Ha
Lehrstuhl für Mikrobiologie and Bayreuther Zentrum für Molekulare Biowissenschaften, Universitat Bayreuth, Universitatsstrasse 30, D 95440 Bayreuth, Germany
J Biol Chem 282:10639-46. 2007..To understand how CO interacts with the active site, we have studied the reactivity of the cluster with potassium cyanide and analyzed the resulting type of nickel coordination by x-ray absorption spectroscopy...
- Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitroHiro aki Yamamoto
University of Tsukuba, Institute of Community Medicine, Tsukuba, Ibaraki, Japan
Toxicology 179:29-36. 2002The effect of potassium cyanide on mitochondria DNA (mtDNA) in mouse brain was investigated in vivo and in vitro. When potassium cyanide (0, 0.1, 1.0 or 2...
- Regulation of ATP/ADP in pancreatic isletsIan R Sweet
Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 53:401-9. 2004..Our results also offer a new method for continuous noninvasive measures of islet cell phosphorylation potential, a critical metabolic variable that controls insulin secretion by ATP-sensitive K(+)-dependent and -independent mechanisms...
- Effects of iron limitation on the respiratory chain and the membrane cytochrome pattern of the Euryarchaeon Halobacterium salinarumDirk Hubmacher
Institut fur Biochemie, Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
Biol Chem 384:1565-73. 2003..Taken together, our results strongly suggest for the first time an important role of iron supply for the bioenergetics of an Archaeon...
- Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signalingKai Chen
Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, 715 Albany Street, MA 02118, USA
J Biol Chem 279:35079-86. 2004..These data establish a novel role for the mitochondrion as a proximal target specific to H(2)O(2)-induced signaling and growth factor transactivation...
- Cyclosporin A-sensitive cytochrome c release and activation of external pathway of NADH oxidation in liver mitochondria due to pore opening by acidification of phosphate-containing incubation mediumD A Knorre
Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
Biosci Rep 23:67-75. 2003....
- Control of ascorbate synthesis by respiration and its implications for stress responsesA Harvey Millar
Plant Molecular Biology Group, School of Biomedical and Chemical Sciences, University of Western Australia, Crawley 6009, Australia
Plant Physiol 133:443-7. 2003
- Stress situations induce cyanide-resistant respiration in spoilage yeastsA Veiga
Dep Botânica e Engenharia Biológica, Instituto Superior de Agronomia, Lisboa, and Centro de Eng Biológica, Fac Ciências Lisboa, Lisboa, Portugal
J Appl Microbiol 95:364-71. 2003..To investigate the conditions that promote the expression of cyanide-resistant respiration (CRR) in the spoilage yeasts Pichia membranifaciens and Debaryomyces hansenii...
- Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiaeAnne Karin Rasmussen
Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
Nucleic Acids Res 31:3909-17. 2003..Together, our data suggest that mitochondrial dysfunction is mutagenic and multiple pathways are involved in this nuclear mutator phenotype...
- Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levelsMark S Turner
Department of Molecular and Cellular Pharmacology, University of Miami, Fla, USA
Circ Res 95:726-33. 2004..The role of this regulated phosphorylation in the adaptation to ischemia remains to be determined...
- p38 Mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosisY Shou
Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907 1333, USA
Toxicol Sci 75:99-107. 2003..These results demonstrated that Bax translocation is critical for cyanide-induced cytochrome c release and that p38 MAP kinase regulates Bax translocation from cytosol to mitochondria...
- Involvement of the alternative oxidase in respiration of Yarrowia lipolytica mitochondria is controlled by the activity of the cytochrome pathwayAleksandr G Medentsev
Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr Nauki 5, Pushchino, Moscow Region 142290, Russia
FEMS Yeast Res 2:519-24. 2002..These data indicate that the alternative system is unable to compete with the cytochrome respiratory chain for electrons. The alternative oxidase only transfers the electrons that are superfluous for the cytochrome respiratory chain...
- Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondriaMiguel Martin
Departamento de Fisiologia, Instituto de Biotecnologia, Universidad de Granada, E 18012 Granada, Spain
Int J Biochem Cell Biol 34:348-57. 2002..Titration studies show that melatonin counteracts the partial inhibition of complex IV induced by 5 microM potassium cyanide. However, melatonin (up to 5mM) was unable to recover the activity of complex IV when it was completely ..
- Mitochondrial-driven bicarbonate transport supports photosynthesis in a marine microalgaI Emma Huertas
Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
Plant Physiol 130:284-91. 2002..This is the first report of a direct role for mitochondria in the energization and functioning of the CCM in a photosynthetic organism...
- Differences in flux control and reserve capacity of cytochrome c oxidase (COX) in human skeletal muscle and brain suggest different metabolic effects of mild COX deficienciesAlexei Kudin
Department of Epileptology, University of Bonn Medical Center, Germany
Mol Biol Rep 29:89-92. 2002..Our results predict stronger metabolic effects of mild COX activity deficits in human skeletal muscle than in brain tissue...
- c-Fos expression in the midbrain periaqueductal gray after chemoreceptor and baroreceptor activationLinda F Hayward
Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL 32601, USA
Am J Physiol Heart Circ Physiol 283:H1975-84. 2002..Chemoreflex responses elicited by repeat intravenous injections of potassium cyanide (KCN; 90 microg/kg) significantly increased FLI in all columns of the PAG relative to saline-injected ..
- NO synthesis, unlike respiration, influences intracellular oxygen tensionJerome Coste
Groupe d électrophysiologie moléculaire, Universite J Fourier, BP 53X, 38041 Grenoble, France
Biochem Biophys Res Commun 290:97-104. 2002..Other cell physiology mechanisms leading to PO(2) variations can now be studied in living cells with this probe...
- Involvement of the parabrachial nucleus in the pressor response to chemoreflex activation in awake ratsAndrea S Haibara
Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Auton Neurosci 101:60-7. 2002Activation of the chemoreflex with potassium cyanide (KCN, 40 microg/rat, i.v.) in awake rats produces pressor and bradycardic responses as well as a tachypneic response...
- Pressor response to chemoreflex activation before and after microinjection of glycine into the NTS of awake ratsFranklin F Pimentel
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
Am J Physiol Regul Integr Comp Physiol 284:R1000-9. 2003..an increase in mean arterial pressure (MAP) and abolished the pressor response to chemoreflex activation [potassium cyanide (n = 7)]...
- Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidaseS Shiva
Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
Proc Natl Acad Sci U S A 98:7212-7. 2001..The implications of this conclusion are discussed in the context of mitochondrial lipid:protein ratios and the importance of NO as a regulator of respiration in pathophysiology...
- Local energy depletion in the basal forebrain increases sleepAnna V Kalinchuk
Department of Physiology, Institute of Biomedicine, PO Box 63, 00014 University of Helsinki, Finland
Eur J Neurosci 17:863-9. 2003..Here we show that energy depletion in localized brain areas can generate sleep. The energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness...
- Glucose loading during primary culture has opposite effects on the viability of hepatocytes exposed to potassium cyanide and to iodoacetic acidK Shiroyama
Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
Metabolism 50:342-8. 2001..on the viability of hepatocytes that were subsequently exposed to the inhibitors of carbohydrate metabolism, potassium cyanide (KCN) and iodoacetic acid (IAA)...
- The respiratory chain complex thresholds in mitochondria of a Drosophila subobscura mutant strainG Farge
Equipe lt lt Génome Mitochondrial gt gt, UMR CNRS 6547, Universite Blaise Pascal, Clermont II, 63177 Aubiere, Cedex, France
Biochimie 84:1189-97. 2002..Our data suggest that the difference in the complex I threshold curves between the wild-type and mutant strains could partially account for the absence of pathological phenotype in the mutant...
- Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidaseMargaret T T Wong-Riley
Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Biol Chem 280:4761-71. 2005..If this is true, then an irreversible inhibitor of cytochrome c oxidase, potassium cyanide (KCN), should compete with LED and reduce its beneficial effects...
- Involvement of L-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart-brainstem preparationValdir A Braga
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
J Physiol 581:1129-45. 2007Peripheral chemoreflex activation with potassium cyanide (KCN) in awake rats or in the working heart-brainstem preparation (WHBP) produces: (a) a sympathoexcitatory/pressor response; (b) bradycardia; and (c) an increase in the frequency ..
- Effects of temperature on pacemaker potentials in the mouse small intestineYoshihiko Kito
Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
Pflugers Arch 454:263-75. 2007..The results also suggest that the mitochondria-induced intracellular Ca(2+) handling system seems to be involved in the initiation of the generation of pacemaker potentials but not in their configuration...
- 2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complexP C Klöhn
Institut fur Toxikologie, Universitat Wurzburg, Germany
FEBS Lett 389:233-7. 1996..The N-OH-AF/NOF interconversion is considered to be involved in the cytotoxicity of 2-acetylaminofluorene in vivo...
- Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblastsH Singh
Department of Chemical Pathology, Adelaide Children s Hospital, South Australia
J Lipid Res 33:1597-605. 1992....
- Resistance to kynurenic acid of the NMDA receptor-dependent toxicity of 3-nitropropionic acid and cyanide in cerebellar granule neuronsAmos A Fatokun
Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, Glasgow G12 8QQ, UK
Brain Res 1215:200-7. 2008..is mimicked by the acute administration of mitochondrial poisons such as 3-nitropropionic acid (3-NPA) and potassium cyanide (KCN), with the production of reactive molecular species secondary to the activation of glutamate receptors...
- Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanideZakia Ben Ramadan
Department of Biochemistry, Trinity College, Dublin, 2, Ireland
Neurochem Res 32:1783-90. 2007..The kinetic behaviour of cyanide activation was consistent with partial (non-essential) competitive activation in all cases...
- Noradrenergic inhibitory modulation in the caudal commissural NTS of the pressor response to chemoreflex activation in awake ratsLuciana C Silva de Oliveira
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
Auton Neurosci 136:63-8. 2007..The data indicate that noradrenaline in the caudal commissural NTS of awake rats may play an important inhibitory neuromodulatory role on the processing of the pressor/sympathoexcitatory component of the chemoreflex...
- In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acidRahul Bhattacharya
Defence Research and Development Establishment, Division of Pharmacology and Toxicology, Gwalior, India
Drug Chem Toxicol 31:149-61. 2008..fructose, mannitol, sorbitol, dihydroxyacetone, and glyoxal (5 or 10 mM; -10 min) against toxicity of potassium cyanide (KCN; 10 mM) in rat thymocytes in vitro...
- Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged ratsZoltan Ungvari
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Am J Physiol Heart Circ Physiol 294:H2121-8. 2008..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...
- Bacterial adaptation to high pressure: a respiratory system in the deep-sea bacterium Shewanella violacea DSS12Sayaka Chikuma
Department of Chemistry, College of Humanities and Sciences, Nihon University, Tokyo, Japan
FEMS Microbiol Lett 267:108-12. 2007..Our results showed that an inhibitor- and pressure-resistant terminal oxidase was expressed in the cells grown under high pressure. This property should contribute to the high-pressure adaptation mechanisms of S. violacea...
- Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase IIIHoang Thi Kim Hong
Faculty of Agriculture, Saga University, 1 Honjo Machi, Saga 840 8502, Japan
J Exp Bot 59:1819-27. 2008..However, malate metabolism by the mMDH system did not operate via a malate-OAA shuttle similarly to Ananas comosus mitochondria, but it operated via a malate-Asp shuttle similarly to Kalanchoë daigremontiana mitochondria...
- Maintenance of ATP favours apoptosis over necrosis triggered by benzamide ribosideM Grusch
Institute of Clinical Pathology, University of Vienna, Austria
Cell Death Differ 9:169-78. 2002..Thus, the monitoring and maintenance of cellular energy pools during therapeutic drug treatment may help to minimize nonspecific side effects and to improve attempted drug effects...
- Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtinTamara Milakovic
Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
J Biol Chem 280:30773-82. 2005..These findings demonstrate that the presence of mutant huntingtin impairs mitochondrial ATP production through one or more mechanisms that do not directly affect the function of the respiration complexes...
- A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosisQuan Li
Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
Free Radic Biol Med 40:173-81. 2006..Our data also suggest that SOD1 release parallels cytochrome c release under all conditions. We propose that intramembranously localized SOD1 is a third reagent (along with AIF) that will regulate apoptosis...
- Electron transport pathways for the oxidation of endogenous substrate(s) in Acidithiobacillus ferrooxidansYongqiang Chen
Department of Microbiology, University of Manitoba, Winnipeg, Canada
Can J Microbiol 52:317-27. 2006..The results are discussed in view of a branched electron transport system of the organism and its possible control...
- Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxiaValdir A Braga
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
Exp Physiol 91:1025-31. 2006..preparation and, using this unanaesthetized experimental preparation, the chemoreflex was activated with potassium cyanide (0...
- Parasympathetic dysfunction is associated with baroreflex and chemoreflex impairment in streptozotocin-induced diabetes in ratsViviane Oliveira Kenne da Silva
Department of Physiological Sciences, Federal School Foundation of Medical Sciences of Porto Alegre and Unilasalle, RS, Brazil
Auton Neurosci 131:28-35. 2007....
- Ablation of NK1 receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake ratsAna Paula L Abdala
Department of Physiology, Universidade Federal de Sao Paulo UNIFESP EPM, Sao Paulo, SP, 04023 062, Brazil
Brain Res 1119:165-73. 2006..Thus, these responses depend critically on NK(1)-receptor bearing neurons in the NTS...
- Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the ratValdir A Braga
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
Clin Exp Pharmacol Physiol 34:1156-9. 2007..This observation may be relevant for the evaluation of neurally induced effects of acute hypoxia on the ventricular myocardium...
- Respiratory pattern in a rat model of epilepsyRuy R Campos
Department of Physiology, UNIFESP, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rue Botucatu 862, CEP 04023 060 São Paulo, SP, Brazil
Epilepsia 44:712-7. 2003..Data regarding respiratory pattern defects during interictal periods also are scarce. Here we sought to generate information with regard to the interictal period in animals with pilocarpine-induced epilepsy...
- Cerebral protective and cognition-improving effects of sinapic acid in rodentsFumito Karakida
Central Research Laboratory, Tsumura and Co, 3586 Yoshiwara Ami machi, Inashiki Gun, Ibaraki 300 1192, Japan
Biol Pharm Bull 30:514-9. 2007..B and 3,6'-disinapoylsucrose in Polygalae Radix, the root of Polygala tenuifolia WILLDENOW, inhibited potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice...
- Antagonism of glutamate receptors in the intermediate and caudal NTS of awake rats produced no changes in the hypertensive response to chemoreflex activationBenedito H Machado
Department Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
Auton Neurosci 117:25-32. 2005..We suggest that neurotransmitter other than l-glutamate may take part in the neurotransmission of the sympathoexcitatory component of the chemoreflex at the NTS level...
- Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenatesH E Badenhorst
Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom 2520, South Africa
J Pharm Pharmacol 57:781-5. 2005..In the lipid peroxidation assay, all the drugs compared favourably to aspirin. This study demonstrates the potential of these agents to be neuroprotective by exerting antioxidant effects...
- Cimetidine: antioxidant and metal-binding propertiesZaynab Lambat
Faculty of Pharmacy, Rhodes University, Box 94 Grahamstown, 6140, South Africa
J Pharm Pharmacol 54:1681-6. 2002..The results imply that cimetidine provides a neuroprotective effect by binding to iron and copper, thus making them unavailable for free radical production...
- Acute toxicity studies of alpha-ketoglutarate: a promising antidote for cyanide poisoningR Bhattacharya
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
J Appl Toxicol 21:495-9. 2001..The results indicate that alpha-KG at 2.0 g kg(-1) (p.o.)-a dose offering maximum antidotal efficacy-is non-toxic and therefore can be considered suitable for cyanide poisoning...
- In vitro and in vivo attenuation of experimental cyanide poisoning by alpha-ketoglutarateR Bhattacharya
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, M P, India
Toxicol Lett 128:185-95. 2002..simultaneous treatment (0 min) of alpha-KG (5 mM) was found to confer significant protection against 5 mM potassium cyanide (KCN) induced cytotoxicity in rat thymocytes as measured by eosin Y exclusion and leakage of intracellular ..
- Effect of pre-treatment of alpha-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodentsRajkumar Tulsawani
Division of Pharmacology and Toxicology, Defence Research and Development Establishment Jhansi Road, Gwalior, M P, India
Biomed Environ Sci 20:56-63. 2007..To investigate the effects of pre-treatment of alpha-ketoglutarate (alpha-KG) on cyanide-induced lethality and changes in various physiological parameters in rodents...
- Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanideR Bhattacharya
Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, Madhya Pradesh, India
Hum Exp Toxicol 21:297-303. 2002..o.) as pretreatment, simultaneous treatment or post-treatment was evaluated against acute potassium cyanide (KCN) poisoning (p.o.) in female rats. Pretreatment with alpha-KG (0.125-2...
- Characterization of two non-homoeologous nuclear genes encoding mitochondrial alternative oxidase in common wheatShigeo Takumi
Faculty of Agriculture, and Division of Life Science, The Graduate School of Science and Technology, Kobe University, Nada Ku, Kobe, Japan
Genes Genet Syst 77:81-8. 2002..The steady-state level of Waox1a and Waox1c transcripts increased under cold stress, while only that of Waox1a was increased by cyanide treatment...
- Characterization of the redox components of transplasma membrane electron transport system from Leishmania donovani promastigotesTanmoy Bera
Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
Biochim Biophys Acta 1725:314-26. 2005..Relatively smaller effects were obtained by treatment with potassium cyanide. Inhibition observed with respect to the reduction of the electron acceptors ALA, DTNS, NQSA and ..
- Inhibition of the bradycardic component of the von Bezold-Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptorsFlorence Netzer
UMR 677 INSERM UMPC, CHU Pitie Salpetriere, Paris, France
Eur J Neurosci 29:2017-28. 2009..of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components ..
- ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cellsMasahiko Watabe
Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi Ward, Tokyo 173 8605, Japan
Neuropharmacology 52:536-41. 2007..In human dopaminergic SH-SY5Y cells, ETCIs (rotenone, thenoyltrifluoroacetone, antimycin A and potassium cyanide) depleted ATP and induced apoptosis...
- The ability of the Comet assay to discriminate between genotoxins and cytotoxinsL Henderson
Environmental Safety Laboratory, Unilever Research, Sharnbrook, UK
Mutagenesis 13:89-94. 1998..Sodium lauryl sulphate and potassium cyanide produced a significant increase in DNA migration at cell survival levels of < or = 75%...
- Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cellsF Okada
Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
Br J Cancer 79:377-85. 1999..of Mn-SOD was significantly higher than that with low level of the antioxidative enzyme in the presence of potassium cyanide, an inhibitor for copper-zinc superoxide dismutase (CuZn-SOD) (P<0.001)...
- A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrinTore Forsingdal Hardlei
Department of Clinical Biochemistry, As, Aarhus University Hospital, Aarhus, Denmark
Clin Chem 55:1002-10. 2009..Transcobalamin (TC) and haptocorrin (HC) are serum corrinoid-binding proteins. We developed new methods for measurement of the corrinoids bound to HC and TC...
- Identification of aldehyde oxidase as the neonicotinoid nitroreductaseRyan A Dick
Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
Chem Res Toxicol 18:317-23. 2005..Second, AOX inhibitors (potassium cyanide, menadione, and promethazine) inhibit metabolite formation when N-methylnicotinamide is utilized as an ..
- Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cellsM Arai
School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108, Japan
J Biol Chem 274:4924-33. 1999..Cell death caused by mitochondrial injury due to potassium cyanide (KCN) or rotenone (chemical hypoxia) was considerably suppressed in the M15 cells, whereas the L9 cells and ..
- Microglia in organotypic hippocampal slice culture and effects of hypoxia: ultrastructure and lipocortin-1 immunoreactivityG G Skibo
Department of Cytology, Bogomoletz Institute of Physiology, 4 Bogomoletz Street, 252024, Kiev, Ukraine
Neuroscience 96:427-38. 2000..as activated and phagocytic cells that appeared in the slice after experimental toxic hypoxia induced by potassium cyanide treatment...
- Nitric oxide induces dose-dependent CA(2+) transients and causes temporal morphological hyperpolarization in human neutrophilsV M Loitto
Department of Medical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
J Cell Physiol 182:402-13. 2000..e. D-penicillamine, glutathione, or potassium cyanide. Increasing doses of SNAP (>/=200 microM) attenuated the Ca(2+) response to the soluble chemotactic ..
- Melatonin in relation to cellular antioxidative defense mechanismsR J Reiter
Department of Cellular and Structural Biology, University of Texas Health Science Center, USA
Horm Metab Res 29:363-72. 1997..melatonin was found to significantly inhibit oxidative damage that is a consequence of paraquat toxicity, potassium cyanide administration, lipopolysaccharide treatment, kainic acid injection, carcinogen administration, carbon ..
- Purification of histidase from Streptomyces griseus and nucleotide sequence of the hutH structural geneP C Wu
Department of Microbiology, Ohio State University, Columbus 43210 1292
J Bacteriol 174:1647-55. 1992..High concentrations of potassium cyanide inactivated histidase in the absence of its substrate or histidinol phosphate, suggesting that, as in other ..
- Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen speciesAmos A Fatokun
Institute of Biomedical and Life Sciences, Room 345, West Medical Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
Eur J Pharmacol 587:35-41. 2008..Cultures were resistant to mitochondrial poisoning by potassium cyanide, but succumbed to 24-h exposures to 3-nitropropionic acid (1 mM)...
- Prostaglandin f2alpha treatment in vivo, but not in vitro, stimulates protein kinase C-activated superoxide production by nonsteroidogenic cells of the rat corpus luteumR F Aten
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
Biol Reprod 59:1069-76. 1998..inhibitor, diphenylene iodonium (ID50 = 5 microM for TPA), but not by the mitochondrial inhibitors, potassium cyanide, rotenone, or sodium azide. Fractionation of cells by centrifugal elutriation showed that TPA-stimulated O2-...
- Mechanical interactions among cytoskeletal filamentsN Wang
Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02115, USA
Hypertension 32:162-5. 1998..Inhibition of oxidative metabolism with potassium cyanide had no effects on stress-induced stiffening response...
- Activation of GABAA but not GABAB receptors in the NTSblocked bradycardia of chemoreflex in awake ratsJ C Callera
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
Am J Physiol 276:H1902-10. 1999..into the nucleus tractus solitarius (NTS) on bradycardic and pressor responses to chemoreflex activation (potassium cyanide, 40 micrograms/rat iv) in awake rats...
- Measuring the mitotic index in chemically-treated human lymphocyte cultures by flow cytometryP A Muehlbauer
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
Mutat Res 537:117-30. 2003..and flow MI frequencies from 24h treatments with mitomycin-C, aphidicolin, eugenol, etoposide, hydroxyrurea, potassium cyanide, staurosporine, ethyl alcohol, noscapine and colcemid((R)) are presented...
- Application of Klebsiella oxytoca immobilized cells on the treatment of cyanide wastewaterC Y Chen
Institute of Environmental Engineering, National Sun Yat Sen University, Kaohsiung 804, Taiwan
Chemosphere 71:133-9. 2008..In this study, potassium cyanide was used as the target compound and both alginate and cellulose triacetate techniques were applied for the ..
- Cholestatic hepatitis caused by acute gold potassium cyanide poisoningM L Wu
Department of Medicine, Taipei Veterans General Hospital, National Yang Ming University, Taiwan
J Toxicol Clin Toxicol 39:739-43. 2001Poisoning after oral ingestion of gold potassium cyanide is rarely reported. A case of suicidal ingestion of gold potassium cyanide (potassium dicyanoaurate; CAS# 13967-50-5) is described.
- P450-catalyzed vs. electrochemical oxidation of haloperidol studied by ultra-performance liquid chromatography/electrospray ionization mass spectrometryTove Johansson Mali'n
Discovery DMPK, AstraZeneca R and D Molndal, Sweden
Rapid Commun Mass Spectrom 24:1231-40. 2010..Liver microsomal incubations and electrochemical oxidation in the presence of potassium cyanide (KCN) resulted in two diastereomeric cyano adducts, proposed to be generated from trapping of the endocyclic ..
- Potentiating effect of an endocrine disruptor, paranonylphenol, on the generation of reactive oxygen species (ROS) in human venous blood -- association with the activation of signal transduction pathwayYasuji Okai
Department of Human Life Science, Osaka Kun Ei Women s College, Sets City, Osaka 566 8501, Japan
J UOEH 29:221-33. 2007..effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, potassium cyanide (KCN), did not exhibit a significant effect...
- Determination of cyanide in blood by isotope-dilution gas chromatography-mass spectrometryKaren E Murphy
National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
Clin Chem 52:458-67. 2006..We describe an automated procedure based on isotope-dilution gas chromatography-mass spectrometry (ID GC/MS) for the accurate and rapid determination of CN in whole blood...
- Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonistsW Tang
Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ 07065, USA
Xenobiotica 38:1437-51. 2008..In incubations fortified with potassium cyanide, a cyano adduct was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis as a ..
- Endothelin and mechanical properties of the carotid artery in Wistar-Kyoto and spontaneously hypertensive ratsG Marano
Laboratorio di Farmacologia, Istituto Superiore di Sanita, Rome, Italy
Cardiovasc Res 41:701-7. 1999..control conditions, as well as with those following complete abolition of vascular smooth muscle tone by potassium cyanide (KCN)...
- Structural and functional reconstruction in situ of the [CuSMoO2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovoransMarcus Resch
Lehrstuhl fur Mikrobiologie, Bayreuther Zentrum für Molekulare Biowissenschaften, Universitat Bayreuth, 95440 Bayreuth, Germany
J Biol Inorg Chem 10:518-28. 2005..of mature and immature forms of CO dehydrogenase were converted into a [MoO(3)] centre by treatment with potassium cyanide. We have established a method, which rescues 50% of the CO dehydrogenase activity by in vitro reconstitution ..
- Purification and characterization of polyphenol oxidase from banana (Musa sapientum L.) pulpC P Yang
Laboratory of Food Science, Faculty of Agriculture, Saga University, Saga 840 8502, Japan
J Agric Food Chem 48:2732-5. 2000..The enzyme activity was completely inhibited by L-ascorbic acid, cysteine, sodium diethyldithiocarbamate, and potassium cyanide. Under a low buffer capacity, the enzyme was also strongly inhibited by citric acid and acetic acid at 10 mM.
- Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake ratsB H Machado
Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
Ann N Y Acad Sci 940:179-96. 2001Chemoreflex activation with potassium cyanide (i.v.) produces pressor and bradycardic responses in awake rats...
- Substrate-selective supramolecular tandem assays: monitoring enzyme inhibition of arginase and diamine oxidase by fluorescent dye displacement from calixarene and cucurbituril macrocyclesWerner M Nau
School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D 28759 Bremen, Germany
J Am Chem Soc 131:11558-70. 2009..e., S-(2-boronoethyl)-L-cysteine and 2(S)-amino-6-boronohexanoic acid for arginase and potassium cyanide for diamine oxidase...
- Prophylactic evaluation of recombinant extracellular superoxide dismutase of Brugia malayi in jird modelSnehal Dabir
Department of Biochemistry and J B Tropical Disease Research Center, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442102, MS, India
Vaccine 26:3705-10. 2008..gel for SOD activity of the expressed recombinant protein revealed that SOD activity inactivated by potassium cyanide and hydrogen peroxide but not by sodium azide, indicating presence of Cu/Zn-SOD...
- Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentrationH Seibert
Institut für Experimentelle Toxikologie, Universitatsklinikum Kiel, Weimarer Str 8, Haus 3, D 24106 Kiel, Germany
Toxicol In Vitro 16:289-97. 2002..and absence of 4% (w/v) albumin varied between 500 (hexachlorophene), 258 (pentachlorophenol) and almost 1 (potassium cyanide, dextropropoxyphene). Calculated molar ratios of substance bound to albumin ranged from 0...
- Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicityH L Liang
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Neuroscience 153:963-74. 2008..light-emitting diode (LED) treatment was therapeutic to neurons functionally inactivated by tetrodotoxin, potassium cyanide (KCN), or methanol intoxication, and LED pretreatment rescued neurons from KCN-induced apoptotic cell death...
- Optimizing the procedure for mercury recovery from dental amalgamFlávia Godoy Iano
School of Dentistry of Bauru, University of Sao Paulo, Bauru, SP, Brazil
Braz Oral Res 22:119-24. 2008..through exposure to direct flame (650 degrees C), long processing time, and hazardous reagents as potassium cyanide. The purpose of this study was to develop a method to replace the direct flame by an electrical mantle in ..
- In vitro and in vivo comparison of sulfur donors as antidotes to acute cyanide intoxicationS I Baskin
Pharmacology Division, US Army Medical Research Institute of Chemical Defence, Aberdeen Proving Ground, MD, USA
J Appl Toxicol 19:173-83. 1999..Separate studies suggest that the chemical reaction of potassium cyanide (KCN) and cystine forms the toxic metabolite 2-iminothiazolidine-4-carboxylic acid...
- Effect of factor XIII on endothelial barrier functionT Noll
Physiologisches Institut, Justus Liebig Universitat, D 35392 Giessen, Germany
J Exp Med 189:1373-82. 1999..Hyperpermeability induced by metabolic inhibition (1 mM potassium cyanide plus 1 mM 2-deoxy-D-glucose) was prevented in the presence of the activated factor XIII A...
- Alterations in membrane transport function and cell viability induced by ATP depletion in primary cultured rabbit renal proximal tubular cellsSung Ju Lee
Department of Physiology, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Busan 602 739, Korea
Korean J Physiol Pharmacol 13:15-22. 2009..ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide (KCN)/0...
- An electron spin resonance spin-trapping investigation of the free radicals formed by the reaction of mitochondrial cytochrome c oxidase with H2O2Y R Chen
Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
J Biol Chem 274:3308-14. 1999..tyrosyl adduct(s). The inhibition of either CcO or NEM-CcO with potassium cyanide prevented detectable MNP adduct formation, indicating heme involvement in the reaction...
- A novel double heme substitution produces a functional bo3 variant of the quinol oxidase aa3 of Bacillus cereus. Purification and paratial characterizationMartha Contreras-Zentella
Instituto de Fisiologia Celular, Facultad de Medicina, and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
J Biol Chem 278:31473-8. 2003..The quinol oxidase activity with tetrachlorohydroquinol was inhibited by potassium cyanide and 2-n-heptyl 4-hydroxyquinoline-N-oxide with an I50 of 24 and 300 microM, respectively...
- Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathiesI P Hargreaves
Neurometabolic Unit, National Hospital and Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Mitochondrion 7:284-7. 2007..b>Potassium cyanide (KCN, 1mM) resulted in a sustained 50% (p<0.01) loss of complex IV...
- Inhibitory effect of bionic fungicide 2-allylphenol on Botrytis cinerea (Pers. ex Fr.) in vitroShuangjun Gong
Department of Plant Pathology, College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, People s Republic of China
Pest Manag Sci 65:1337-43. 2009..bark. 2-Allylphenol has been used in China for 10 years. However, its biochemical mode of action remains unclear. An in vitro study was conducted on the biochemical mechanism of 2-allyphenol inhibiting Botrytis cinerea (Pers. ex Fr.)...
- Hydrogen peroxide generation by the pepper extracellular peroxidase CaPO2 activates local and systemic cell death and defense response to bacterial pathogensHyong Woo Choi
College of Life Sciences and Biotechnology, Korea University, Seoul 136 713, Republic of Korea
Plant Physiol 145:890-904. 2007..Arabidopsis leaves infected by Pseudomonas syringae pv tomato, H(2)O(2) generation was sensitive to potassium cyanide (a peroxidase inhibitor) but insensitive to diphenylene iodonium (an NADPH oxidase inhibitor), suggesting ..
- Acute cyanide poisoning among jewelry and textile industry workersLuís Coentrão
Institute of Pharmacology and Therapeutics, University of Porto, Portugal
Am J Emerg Med 29:78-81. 2011..the study period, 8 (7 males, 1 female; age 36 ± 11 years, mean ± SD) attempted suicide by ingestion of potassium cyanide used in their profession as goldsmiths or textile industry workers...
- Determination of catecholamines in pheochromocytoma cell (PC-12) culture medium by microdialysis-microbore liquid chromatographyF C Cheng
Department of Medical Research, Taichung Veterans General Hospital, Taiwan
J Chromatogr A 870:405-11. 2000..29 ng/ml which was elevated to 2.43 ng/ml after treatment with 0.5 mM potassium cyanide. In conclusion, the present microassay provides for the sensitive, direct measurement of catecholamines in ..
- Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifoliaYukinobu Ikeya
Research Division, Tsumura and Co, Ibaraki, Japan
Biol Pharm Bull 27:1081-5. 2004..tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ..
- Reactions of pholasin with peroxidases and hypochlorous acidS Reichl
Institute of Medical Physics and Biophysics, School of Medicine, University of Leipzig, Leipzig, Germany
Free Radic Biol Med 28:1555-63. 2000..This is shown by the inhibition of luminescence with superoxide dismutase and potassium cyanide, together with the lack of effect of both methionine and taurine...
- RNAi in DNA Sequence Elimination in TetrahymenaMartin A Gorovsky; Fiscal Year: 2010..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
- Repeated Genes: Organization, Evolution, and FunctionMARTIN GOROVSKY; Fiscal Year: 2008..unreadable] [unreadable]..
- CONTROL OF GENE ACTIVITY AND ORGANELLE BIOGENESISMARTIN GOROVSKY; Fiscal Year: 2006..abstract_text> ..
- MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLSLawrence Lash; Fiscal Year: 2007..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
- Supramedullary control of respirationLinda Hayward; Fiscal Year: 2007..Furthermore, the results of this study will provide new insights into understanding of the role of supramedullary structures in modulating respiratory timing. [unreadable] [unreadable]..
- METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEXMargaret Wong Riley; Fiscal Year: 2002..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
- 5-HT1A-agonist mediated recovery in hypovolemic shockKarie Scrogin; Fiscal Year: 2007..We will also assess the ability of clinically available 5-HT1A agonists to delay the transition from hypovolemic shock to circulatory collapse. ..
- Mechanism and Assessment of Hypoxia-Induced Islet DeathIAN SWEET; Fiscal Year: 2005..abstract_text> ..
- GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURYLawrence Lash; Fiscal Year: 2003..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
- Instrument to Measure Oxygen Affinity of HemoglobinKim Vandegriff; Fiscal Year: 2004..abstract_text> ..
- PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVELinda Hayward; Fiscal Year: 2002..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
- Neurochemical Organization of Brain Stem Respiratory NucleiMARGARET TT WONG RILEY; Fiscal Year: 2010....
- MITOCHONDRIA AND PULMONARY ENDOTHELIAL CELL DEATHJames Peterson; Fiscal Year: 2007..abstract_text> ..
- Cyanide-induced Neurotoxicity: Molecular Death SignalingGary Isom; Fiscal Year: 2008..This study will provide valuable insight into neurotoxicant-induced neurodegeneration and fundamental information on regulation of cell death in the CNS. ..