potassium cyanide

Summary

Summary: A highly poisonous compound that is an inhibitor of many metabolic processes, but has been shown to be an especially potent inhibitor of heme enzymes and hemeproteins. It is used in many industrial processes.

Top Publications

  1. ncbi Evaluation of effects of prenatal exposure to the cyanide and thiocyanate in wistar rats
    Altamir Benedito de Sousa
    Research Center for Veterinary Toxicology CEPTOX, Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Reprod Toxicol 23:568-77. 2007
  2. ncbi Cardiovascular responses to chemoreflex activation with potassium cyanide or hypoxic hypoxia in awake rats
    Renata C H Barros
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, SP, Brazil
    Auton Neurosci 97:110-5. 2002
  3. ncbi Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide
    Khanit Suwanborirux
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    J Nat Prod 66:1441-6. 2003
  4. ncbi Hydroxocobalamin for poisoning caused by ingestion of potassium cyanide: a case study
    Jean Luc Fortin
    SAMU 25, CHU J Minjoz, Besancon, France
    J Emerg Med 39:320-4. 2010
  5. ncbi Interaction of potassium cyanide with the [Ni-4Fe-5S] active site cluster of CO dehydrogenase from Carboxydothermus hydrogenoformans
    Seung Wook Ha
    Lehrstuhl für Mikrobiologie and Bayreuther Zentrum für Molekulare Biowissenschaften, Universitat Bayreuth, Universitatsstrasse 30, D 95440 Bayreuth, Germany
    J Biol Chem 282:10639-46. 2007
  6. ncbi Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro
    Hiro aki Yamamoto
    University of Tsukuba, Institute of Community Medicine, Tsukuba, Ibaraki, Japan
    Toxicology 179:29-36. 2002
  7. ncbi Regulation of ATP/ADP in pancreatic islets
    Ian R Sweet
    Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 53:401-9. 2004
  8. ncbi Effects of iron limitation on the respiratory chain and the membrane cytochrome pattern of the Euryarchaeon Halobacterium salinarum
    Dirk Hubmacher
    Institut fur Biochemie, Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Biol Chem 384:1565-73. 2003
  9. ncbi Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling
    Kai Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, 715 Albany Street, MA 02118, USA
    J Biol Chem 279:35079-86. 2004
  10. ncbi Cyclosporin A-sensitive cytochrome c release and activation of external pathway of NADH oxidation in liver mitochondria due to pore opening by acidification of phosphate-containing incubation medium
    D A Knorre
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    Biosci Rep 23:67-75. 2003

Research Grants

  1. RNAi in DNA Sequence Elimination in Tetrahymena
    Martin A Gorovsky; Fiscal Year: 2010
  2. Repeated Genes: Organization, Evolution, and Function
    MARTIN GOROVSKY; Fiscal Year: 2008
  3. CONTROL OF GENE ACTIVITY AND ORGANELLE BIOGENESIS
    MARTIN GOROVSKY; Fiscal Year: 2006
  4. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
  5. Supramedullary control of respiration
    Linda Hayward; Fiscal Year: 2007
  6. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
  7. 5-HT1A-agonist mediated recovery in hypovolemic shock
    Karie Scrogin; Fiscal Year: 2007
  8. Mechanism and Assessment of Hypoxia-Induced Islet Death
    IAN SWEET; Fiscal Year: 2005
  9. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
  10. Instrument to Measure Oxygen Affinity of Hemoglobin
    Kim Vandegriff; Fiscal Year: 2004

Detail Information

Publications229 found, 100 shown here

  1. ncbi Evaluation of effects of prenatal exposure to the cyanide and thiocyanate in wistar rats
    Altamir Benedito de Sousa
    Research Center for Veterinary Toxicology CEPTOX, Department of Pathology, School of Veterinary Medicine, University of Sao Paulo, Sao Paulo, Brazil
    Reprod Toxicol 23:568-77. 2007
    A study was performed at term and at weaning to verify the toxic effects of the prenatal exposure to potassium cyanide (KCN) and potassium thiocyanate (KSCN) in pregnant Wistar rats...
  2. ncbi Cardiovascular responses to chemoreflex activation with potassium cyanide or hypoxic hypoxia in awake rats
    Renata C H Barros
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, SP, Brazil
    Auton Neurosci 97:110-5. 2002
    Although intravenous (iv) injection of potassium cyanide (KCN) activates the arterial chemoreflex, it has been questioned whether cytotoxic hypoxia reproduces a physiological stimulus such as hypoxic hypoxia (low inspired O2 tension)...
  3. ncbi Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide
    Khanit Suwanborirux
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    J Nat Prod 66:1441-6. 2003
    Renieramycins M (1m) and N (1n) were isolated from the Thai sponge Xestospongia sp., pretreated with potassium cyanide in methanolic buffer solution, and their structures and relative stereochemistries were elucidated on the basis of ..
  4. ncbi Hydroxocobalamin for poisoning caused by ingestion of potassium cyanide: a case study
    Jean Luc Fortin
    SAMU 25, CHU J Minjoz, Besancon, France
    J Emerg Med 39:320-4. 2010
    ..The case supports the efficacy of hydroxocobalamin for acute cyanide poisoning caused by ingestion of a cyanide salt. No adverse events attributed to hydroxocobalamin were observed...
  5. ncbi Interaction of potassium cyanide with the [Ni-4Fe-5S] active site cluster of CO dehydrogenase from Carboxydothermus hydrogenoformans
    Seung Wook Ha
    Lehrstuhl für Mikrobiologie and Bayreuther Zentrum für Molekulare Biowissenschaften, Universitat Bayreuth, Universitatsstrasse 30, D 95440 Bayreuth, Germany
    J Biol Chem 282:10639-46. 2007
    ..To understand how CO interacts with the active site, we have studied the reactivity of the cluster with potassium cyanide and analyzed the resulting type of nickel coordination by x-ray absorption spectroscopy...
  6. ncbi Melatonin attenuates brain mitochondria DNA damage induced by potassium cyanide in vivo and in vitro
    Hiro aki Yamamoto
    University of Tsukuba, Institute of Community Medicine, Tsukuba, Ibaraki, Japan
    Toxicology 179:29-36. 2002
    The effect of potassium cyanide on mitochondria DNA (mtDNA) in mouse brain was investigated in vivo and in vitro. When potassium cyanide (0, 0.1, 1.0 or 2...
  7. ncbi Regulation of ATP/ADP in pancreatic islets
    Ian R Sweet
    Robert H Williams Laboratory, Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes 53:401-9. 2004
    ..Our results also offer a new method for continuous noninvasive measures of islet cell phosphorylation potential, a critical metabolic variable that controls insulin secretion by ATP-sensitive K(+)-dependent and -independent mechanisms...
  8. ncbi Effects of iron limitation on the respiratory chain and the membrane cytochrome pattern of the Euryarchaeon Halobacterium salinarum
    Dirk Hubmacher
    Institut fur Biochemie, Universitat zu Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Biol Chem 384:1565-73. 2003
    ..Taken together, our results strongly suggest for the first time an important role of iron supply for the bioenergetics of an Archaeon...
  9. ncbi Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling
    Kai Chen
    Evans Memorial Department of Medicine and Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, 715 Albany Street, MA 02118, USA
    J Biol Chem 279:35079-86. 2004
    ..These data establish a novel role for the mitochondrion as a proximal target specific to H(2)O(2)-induced signaling and growth factor transactivation...
  10. ncbi Cyclosporin A-sensitive cytochrome c release and activation of external pathway of NADH oxidation in liver mitochondria due to pore opening by acidification of phosphate-containing incubation medium
    D A Knorre
    Department of Bioenergetics, A N Belozersky Institute of Physico Chemical Biology, Moscow State University, Moscow, Russia
    Biosci Rep 23:67-75. 2003
    ....
  11. pmc Control of ascorbate synthesis by respiration and its implications for stress responses
    A Harvey Millar
    Plant Molecular Biology Group, School of Biomedical and Chemical Sciences, University of Western Australia, Crawley 6009, Australia
    Plant Physiol 133:443-7. 2003
  12. ncbi Stress situations induce cyanide-resistant respiration in spoilage yeasts
    A Veiga
    Dep Botânica e Engenharia Biológica, Instituto Superior de Agronomia, Lisboa, and Centro de Eng Biológica, Fac Ciências Lisboa, Lisboa, Portugal
    J Appl Microbiol 95:364-71. 2003
    ..To investigate the conditions that promote the expression of cyanide-resistant respiration (CRR) in the spoilage yeasts Pichia membranifaciens and Debaryomyces hansenii...
  13. pmc Mitochondria-mediated nuclear mutator phenotype in Saccharomyces cerevisiae
    Anne Karin Rasmussen
    Sidney Kimmel Cancer Center, Johns Hopkins School of Medicine, Bunting Blaustein Cancer Research Building, 1650 Orleans Street, Baltimore, MD 21231, USA
    Nucleic Acids Res 31:3909-17. 2003
    ..Together, our data suggest that mitochondrial dysfunction is mutagenic and multiple pathways are involved in this nuclear mutator phenotype...
  14. ncbi Reversible connexin 43 dephosphorylation during hypoxia and reoxygenation is linked to cellular ATP levels
    Mark S Turner
    Department of Molecular and Cellular Pharmacology, University of Miami, Fla, USA
    Circ Res 95:726-33. 2004
    ..The role of this regulated phosphorylation in the adaptation to ischemia remains to be determined...
  15. ncbi p38 Mitogen-activated protein kinase regulates Bax translocation in cyanide-induced apoptosis
    Y Shou
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907 1333, USA
    Toxicol Sci 75:99-107. 2003
    ..These results demonstrated that Bax translocation is critical for cyanide-induced cytochrome c release and that p38 MAP kinase regulates Bax translocation from cytosol to mitochondria...
  16. ncbi Involvement of the alternative oxidase in respiration of Yarrowia lipolytica mitochondria is controlled by the activity of the cytochrome pathway
    Aleksandr G Medentsev
    Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr Nauki 5, Pushchino, Moscow Region 142290, Russia
    FEMS Yeast Res 2:519-24. 2002
    ..These data indicate that the alternative system is unable to compete with the cytochrome respiratory chain for electrons. The alternative oxidase only transfers the electrons that are superfluous for the cytochrome respiratory chain...
  17. ncbi Melatonin increases the activity of the oxidative phosphorylation enzymes and the production of ATP in rat brain and liver mitochondria
    Miguel Martin
    Departamento de Fisiologia, Instituto de Biotecnologia, Universidad de Granada, E 18012 Granada, Spain
    Int J Biochem Cell Biol 34:348-57. 2002
    ..Titration studies show that melatonin counteracts the partial inhibition of complex IV induced by 5 microM potassium cyanide. However, melatonin (up to 5mM) was unable to recover the activity of complex IV when it was completely ..
  18. pmc Mitochondrial-driven bicarbonate transport supports photosynthesis in a marine microalga
    I Emma Huertas
    Department of Biology, York University, 4700 Keele Street, Toronto, Ontario, Canada M3J 1P3
    Plant Physiol 130:284-91. 2002
    ..This is the first report of a direct role for mitochondria in the energization and functioning of the CCM in a photosynthetic organism...
  19. ncbi Differences in flux control and reserve capacity of cytochrome c oxidase (COX) in human skeletal muscle and brain suggest different metabolic effects of mild COX deficiencies
    Alexei Kudin
    Department of Epileptology, University of Bonn Medical Center, Germany
    Mol Biol Rep 29:89-92. 2002
    ..Our results predict stronger metabolic effects of mild COX activity deficits in human skeletal muscle than in brain tissue...
  20. ncbi c-Fos expression in the midbrain periaqueductal gray after chemoreceptor and baroreceptor activation
    Linda F Hayward
    Department of Physiological Sciences, University of Florida College of Veterinary Medicine, Gainesville, FL 32601, USA
    Am J Physiol Heart Circ Physiol 283:H1975-84. 2002
    ..Chemoreflex responses elicited by repeat intravenous injections of potassium cyanide (KCN; 90 microg/kg) significantly increased FLI in all columns of the PAG relative to saline-injected ..
  21. ncbi NO synthesis, unlike respiration, influences intracellular oxygen tension
    Jerome Coste
    Groupe d électrophysiologie moléculaire, Universite J Fourier, BP 53X, 38041 Grenoble, France
    Biochem Biophys Res Commun 290:97-104. 2002
    ..Other cell physiology mechanisms leading to PO(2) variations can now be studied in living cells with this probe...
  22. ncbi Involvement of the parabrachial nucleus in the pressor response to chemoreflex activation in awake rats
    Andrea S Haibara
    Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
    Auton Neurosci 101:60-7. 2002
    Activation of the chemoreflex with potassium cyanide (KCN, 40 microg/rat, i.v.) in awake rats produces pressor and bradycardic responses as well as a tachypneic response...
  23. ncbi Pressor response to chemoreflex activation before and after microinjection of glycine into the NTS of awake rats
    Franklin F Pimentel
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Am J Physiol Regul Integr Comp Physiol 284:R1000-9. 2003
    ..an increase in mean arterial pressure (MAP) and abolished the pressor response to chemoreflex activation [potassium cyanide (n = 7)]...
  24. pmc Nitric oxide partitioning into mitochondrial membranes and the control of respiration at cytochrome c oxidase
    S Shiva
    Department of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Proc Natl Acad Sci U S A 98:7212-7. 2001
    ..The implications of this conclusion are discussed in the context of mitochondrial lipid:protein ratios and the importance of NO as a regulator of respiration in pathophysiology...
  25. ncbi Local energy depletion in the basal forebrain increases sleep
    Anna V Kalinchuk
    Department of Physiology, Institute of Biomedicine, PO Box 63, 00014 University of Helsinki, Finland
    Eur J Neurosci 17:863-9. 2003
    ..Here we show that energy depletion in localized brain areas can generate sleep. The energy depletion model of sleep induction could be applied to in vitro research into the cellular mechanisms of prolonged wakefulness...
  26. ncbi Glucose loading during primary culture has opposite effects on the viability of hepatocytes exposed to potassium cyanide and to iodoacetic acid
    K Shiroyama
    Department of Anesthesiology and Critical Care Medicine, Hiroshima University School of Medicine, Hiroshima, Japan
    Metabolism 50:342-8. 2001
    ..on the viability of hepatocytes that were subsequently exposed to the inhibitors of carbohydrate metabolism, potassium cyanide (KCN) and iodoacetic acid (IAA)...
  27. ncbi The respiratory chain complex thresholds in mitochondria of a Drosophila subobscura mutant strain
    G Farge
    Equipe lt lt Génome Mitochondrial gt gt, UMR CNRS 6547, Universite Blaise Pascal, Clermont II, 63177 Aubiere, Cedex, France
    Biochimie 84:1189-97. 2002
    ..Our data suggest that the difference in the complex I threshold curves between the wild-type and mutant strains could partially account for the absence of pathological phenotype in the mutant...
  28. ncbi Photobiomodulation directly benefits primary neurons functionally inactivated by toxins: role of cytochrome c oxidase
    Margaret T T Wong-Riley
    Department of Cell Biology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Biol Chem 280:4761-71. 2005
    ..If this is true, then an irreversible inhibitor of cytochrome c oxidase, potassium cyanide (KCN), should compete with LED and reduce its beneficial effects...
  29. pmc Involvement of L-glutamate and ATP in the neurotransmission of the sympathoexcitatory component of the chemoreflex in the commissural nucleus tractus solitarii of awake rats and in the working heart-brainstem preparation
    Valdir A Braga
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    J Physiol 581:1129-45. 2007
    Peripheral chemoreflex activation with potassium cyanide (KCN) in awake rats or in the working heart-brainstem preparation (WHBP) produces: (a) a sympathoexcitatory/pressor response; (b) bradycardia; and (c) an increase in the frequency ..
  30. ncbi Effects of temperature on pacemaker potentials in the mouse small intestine
    Yoshihiko Kito
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    Pflugers Arch 454:263-75. 2007
    ..The results also suggest that the mitochondria-induced intracellular Ca(2+) handling system seems to be involved in the initiation of the generation of pacemaker potentials but not in their configuration...
  31. ncbi 2-Nitrosofluorene and N-hydroxy-2-aminofluorene react with the ubiquinone-reduction center (center N) of the mitochondrial cytochrome bc1 complex
    P C Klöhn
    Institut fur Toxikologie, Universitat Wurzburg, Germany
    FEBS Lett 389:233-7. 1996
    ..The N-OH-AF/NOF interconversion is considered to be involved in the cytotoxicity of 2-acetylaminofluorene in vivo...
  32. ncbi Peroxisomal beta-oxidation of branched chain fatty acids in human skin fibroblasts
    H Singh
    Department of Chemical Pathology, Adelaide Children s Hospital, South Australia
    J Lipid Res 33:1597-605. 1992
    ....
  33. ncbi Resistance to kynurenic acid of the NMDA receptor-dependent toxicity of 3-nitropropionic acid and cyanide in cerebellar granule neurons
    Amos A Fatokun
    Institute of Biomedical and Life Sciences, University of Glasgow, West Medical Building, Glasgow G12 8QQ, UK
    Brain Res 1215:200-7. 2008
    ..is mimicked by the acute administration of mitochondrial poisons such as 3-nitropropionic acid (3-NPA) and potassium cyanide (KCN), with the production of reactive molecular species secondary to the activation of glutamate receptors...
  34. ncbi Species differences in the selective inhibition of monoamine oxidase (1-methyl-2-phenylethyl)hydrazine and its potentiation by cyanide
    Zakia Ben Ramadan
    Department of Biochemistry, Trinity College, Dublin, 2, Ireland
    Neurochem Res 32:1783-90. 2007
    ..The kinetic behaviour of cyanide activation was consistent with partial (non-essential) competitive activation in all cases...
  35. ncbi Noradrenergic inhibitory modulation in the caudal commissural NTS of the pressor response to chemoreflex activation in awake rats
    Luciana C Silva de Oliveira
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Av Bandeirantes, 3900, 14049 900, Ribeirao Preto, SP, Brazil
    Auton Neurosci 136:63-8. 2007
    ..The data indicate that noradrenaline in the caudal commissural NTS of awake rats may play an important inhibitory neuromodulatory role on the processing of the pressor/sympathoexcitatory component of the chemoreflex...
  36. ncbi In vitro and in vivo evaluation of various carbonyl compounds against cyanide toxicity with particular reference to alpha-ketoglutaric acid
    Rahul Bhattacharya
    Defence Research and Development Establishment, Division of Pharmacology and Toxicology, Gwalior, India
    Drug Chem Toxicol 31:149-61. 2008
    ..fructose, mannitol, sorbitol, dihydroxyacetone, and glyoxal (5 or 10 mM; -10 min) against toxicity of potassium cyanide (KCN; 10 mM) in rat thymocytes in vitro...
  37. ncbi Dysregulation of mitochondrial biogenesis in vascular endothelial and smooth muscle cells of aged rats
    Zoltan Ungvari
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Heart Circ Physiol 294:H2121-8. 2008
    ..We posit that impaired mitochondrial biogenesis and downregulation of COX may contribute to the increased mitochondrial oxidative stress in aged endothelial cells...
  38. ncbi Bacterial adaptation to high pressure: a respiratory system in the deep-sea bacterium Shewanella violacea DSS12
    Sayaka Chikuma
    Department of Chemistry, College of Humanities and Sciences, Nihon University, Tokyo, Japan
    FEMS Microbiol Lett 267:108-12. 2007
    ..Our results showed that an inhibitor- and pressure-resistant terminal oxidase was expressed in the cells grown under high pressure. This property should contribute to the high-pressure adaptation mechanisms of S. violacea...
  39. ncbi Malate metabolism in Hoya carnosa mitochondria and its role in photosynthesis during CAM phase III
    Hoang Thi Kim Hong
    Faculty of Agriculture, Saga University, 1 Honjo Machi, Saga 840 8502, Japan
    J Exp Bot 59:1819-27. 2008
    ..However, malate metabolism by the mMDH system did not operate via a malate-OAA shuttle similarly to Ananas comosus mitochondria, but it operated via a malate-Asp shuttle similarly to Kalanchoë daigremontiana mitochondria...
  40. ncbi Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside
    M Grusch
    Institute of Clinical Pathology, University of Vienna, Austria
    Cell Death Differ 9:169-78. 2002
    ..Thus, the monitoring and maintenance of cellular energy pools during therapeutic drug treatment may help to minimize nonspecific side effects and to improve attempted drug effects...
  41. ncbi Mitochondrial respiration and ATP production are significantly impaired in striatal cells expressing mutant huntingtin
    Tamara Milakovic
    Department of Psychiatry, University of Alabama at Birmingham, Birmingham, Alabama 35294 0017, USA
    J Biol Chem 280:30773-82. 2005
    ..These findings demonstrate that the presence of mutant huntingtin impairs mitochondrial ATP production through one or more mechanisms that do not directly affect the function of the respiration complexes...
  42. ncbi A possible cooperation of SOD1 and cytochrome c in mitochondria-dependent apoptosis
    Quan Li
    Department of Biochemistry and Molecular Pathology, Osaka City University Medical School, 1 4 3 Asahimachi, Abeno, Osaka 545 8585, Japan
    Free Radic Biol Med 40:173-81. 2006
    ..Our data also suggest that SOD1 release parallels cytochrome c release under all conditions. We propose that intramembranously localized SOD1 is a third reagent (along with AIF) that will regulate apoptosis...
  43. ncbi Electron transport pathways for the oxidation of endogenous substrate(s) in Acidithiobacillus ferrooxidans
    Yongqiang Chen
    Department of Microbiology, University of Manitoba, Winnipeg, Canada
    Can J Microbiol 52:317-27. 2006
    ..The results are discussed in view of a branched electron transport system of the organism and its possible control...
  44. ncbi Sympathoexcitatory response to peripheral chemoreflex activation is enhanced in juvenile rats exposed to chronic intermittent hypoxia
    Valdir A Braga
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Exp Physiol 91:1025-31. 2006
    ..preparation and, using this unanaesthetized experimental preparation, the chemoreflex was activated with potassium cyanide (0...
  45. ncbi Parasympathetic dysfunction is associated with baroreflex and chemoreflex impairment in streptozotocin-induced diabetes in rats
    Viviane Oliveira Kenne da Silva
    Department of Physiological Sciences, Federal School Foundation of Medical Sciences of Porto Alegre and Unilasalle, RS, Brazil
    Auton Neurosci 131:28-35. 2007
    ....
  46. ncbi Ablation of NK1 receptor bearing neurons in the nucleus of the solitary tract blunts cardiovascular reflexes in awake rats
    Ana Paula L Abdala
    Department of Physiology, Universidade Federal de Sao Paulo UNIFESP EPM, Sao Paulo, SP, 04023 062, Brazil
    Brain Res 1119:165-73. 2006
    ..Thus, these responses depend critically on NK(1)-receptor bearing neurons in the NTS...
  47. ncbi Activation of peripheral chemoreceptors causes positive inotropic effects in a working heart-brainstem preparation of the rat
    Valdir A Braga
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    Clin Exp Pharmacol Physiol 34:1156-9. 2007
    ..This observation may be relevant for the evaluation of neurally induced effects of acute hypoxia on the ventricular myocardium...
  48. ncbi Respiratory pattern in a rat model of epilepsy
    Ruy R Campos
    Department of Physiology, UNIFESP, Escola Paulista de Medicina, Universidade Federal de Sao Paulo, Rue Botucatu 862, CEP 04023 060 São Paulo, SP, Brazil
    Epilepsia 44:712-7. 2003
    ..Data regarding respiratory pattern defects during interictal periods also are scarce. Here we sought to generate information with regard to the interictal period in animals with pilocarpine-induced epilepsy...
  49. ncbi Cerebral protective and cognition-improving effects of sinapic acid in rodents
    Fumito Karakida
    Central Research Laboratory, Tsumura and Co, 3586 Yoshiwara Ami machi, Inashiki Gun, Ibaraki 300 1192, Japan
    Biol Pharm Bull 30:514-9. 2007
    ..B and 3,6'-disinapoylsucrose in Polygalae Radix, the root of Polygala tenuifolia WILLDENOW, inhibited potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice...
  50. ncbi Antagonism of glutamate receptors in the intermediate and caudal NTS of awake rats produced no changes in the hypertensive response to chemoreflex activation
    Benedito H Machado
    Department Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Auton Neurosci 117:25-32. 2005
    ..We suggest that neurotransmitter other than l-glutamate may take part in the neurotransmission of the sympathoexcitatory component of the chemoreflex at the NTS level...
  51. ncbi Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates
    H E Badenhorst
    Pharmaceutical Chemistry, School of Pharmacy, North West University, Potchefstroom 2520, South Africa
    J Pharm Pharmacol 57:781-5. 2005
    ..In the lipid peroxidation assay, all the drugs compared favourably to aspirin. This study demonstrates the potential of these agents to be neuroprotective by exerting antioxidant effects...
  52. ncbi Cimetidine: antioxidant and metal-binding properties
    Zaynab Lambat
    Faculty of Pharmacy, Rhodes University, Box 94 Grahamstown, 6140, South Africa
    J Pharm Pharmacol 54:1681-6. 2002
    ..The results imply that cimetidine provides a neuroprotective effect by binding to iron and copper, thus making them unavailable for free radical production...
  53. ncbi Acute toxicity studies of alpha-ketoglutarate: a promising antidote for cyanide poisoning
    R Bhattacharya
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, India
    J Appl Toxicol 21:495-9. 2001
    ..The results indicate that alpha-KG at 2.0 g kg(-1) (p.o.)-a dose offering maximum antidotal efficacy-is non-toxic and therefore can be considered suitable for cyanide poisoning...
  54. ncbi In vitro and in vivo attenuation of experimental cyanide poisoning by alpha-ketoglutarate
    R Bhattacharya
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474 002, M P, India
    Toxicol Lett 128:185-95. 2002
    ..simultaneous treatment (0 min) of alpha-KG (5 mM) was found to confer significant protection against 5 mM potassium cyanide (KCN) induced cytotoxicity in rat thymocytes as measured by eosin Y exclusion and leakage of intracellular ..
  55. ncbi Effect of pre-treatment of alpha-ketoglutarate on cyanide-induced toxicity and alterations in various physiological variables in rodents
    Rajkumar Tulsawani
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment Jhansi Road, Gwalior, M P, India
    Biomed Environ Sci 20:56-63. 2007
    ..To investigate the effects of pre-treatment of alpha-ketoglutarate (alpha-KG) on cyanide-induced lethality and changes in various physiological parameters in rodents...
  56. ncbi Promising role of alpha-ketoglutarate in protecting against the lethal effects of cyanide
    R Bhattacharya
    Division of Pharmacology and Toxicology, Defence Research and Development Establishment, Jhansi Road, Gwalior 474002, Madhya Pradesh, India
    Hum Exp Toxicol 21:297-303. 2002
    ..o.) as pretreatment, simultaneous treatment or post-treatment was evaluated against acute potassium cyanide (KCN) poisoning (p.o.) in female rats. Pretreatment with alpha-KG (0.125-2...
  57. ncbi Characterization of two non-homoeologous nuclear genes encoding mitochondrial alternative oxidase in common wheat
    Shigeo Takumi
    Faculty of Agriculture, and Division of Life Science, The Graduate School of Science and Technology, Kobe University, Nada Ku, Kobe, Japan
    Genes Genet Syst 77:81-8. 2002
    ..The steady-state level of Waox1a and Waox1c transcripts increased under cold stress, while only that of Waox1a was increased by cyanide treatment...
  58. ncbi Characterization of the redox components of transplasma membrane electron transport system from Leishmania donovani promastigotes
    Tanmoy Bera
    Division of Medicinal Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India
    Biochim Biophys Acta 1725:314-26. 2005
    ..Relatively smaller effects were obtained by treatment with potassium cyanide. Inhibition observed with respect to the reduction of the electron acceptors ALA, DTNS, NQSA and ..
  59. ncbi Inhibition of the bradycardic component of the von Bezold-Jarisch reflex and carotid chemoreceptor reflex by periaqueductal gray stimulation: involvement of medullary receptors
    Florence Netzer
    UMR 677 INSERM UMPC, CHU Pitie Salpetriere, Paris, France
    Eur J Neurosci 29:2017-28. 2009
    ..of dlPAG stimulation on the reflex bradycardia triggered by systemic administration of phenylbiguanide or potassium cyanide. Electrical and chemical stimulation of the dlPAG produced marked inhibition of the cardiovagal components ..
  60. ncbi ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cells
    Masahiko Watabe
    Department of Pharmacology, Teikyo University School of Medicine, 2 11 1 Kaga, Itabashi Ward, Tokyo 173 8605, Japan
    Neuropharmacology 52:536-41. 2007
    ..In human dopaminergic SH-SY5Y cells, ETCIs (rotenone, thenoyltrifluoroacetone, antimycin A and potassium cyanide) depleted ATP and induced apoptosis...
  61. ncbi The ability of the Comet assay to discriminate between genotoxins and cytotoxins
    L Henderson
    Environmental Safety Laboratory, Unilever Research, Sharnbrook, UK
    Mutagenesis 13:89-94. 1998
    ..Sodium lauryl sulphate and potassium cyanide produced a significant increase in DNA migration at cell survival levels of < or = 75%...
  62. pmc Inflammatory cell-mediated tumour progression and minisatellite mutation correlate with the decrease of antioxidative enzymes in murine fibrosarcoma cells
    F Okada
    Laboratory of Pathology, Cancer Institute, Hokkaido University School of Medicine, Sapporo, Japan
    Br J Cancer 79:377-85. 1999
    ..of Mn-SOD was significantly higher than that with low level of the antioxidative enzyme in the presence of potassium cyanide, an inhibitor for copper-zinc superoxide dismutase (CuZn-SOD) (P<0.001)...
  63. ncbi A new principle for measurement of cobalamin and corrinoids, used for studies of cobalamin analogs on serum haptocorrin
    Tore Forsingdal Hardlei
    Department of Clinical Biochemistry, As, Aarhus University Hospital, Aarhus, Denmark
    Clin Chem 55:1002-10. 2009
    ..Transcobalamin (TC) and haptocorrin (HC) are serum corrinoid-binding proteins. We developed new methods for measurement of the corrinoids bound to HC and TC...
  64. ncbi Identification of aldehyde oxidase as the neonicotinoid nitroreductase
    Ryan A Dick
    Environmental Chemistry and Toxicology Laboratory, Department of Environmental Science, Policy and Management, University of California, Berkeley, California 94720 3112, USA
    Chem Res Toxicol 18:317-23. 2005
    ..Second, AOX inhibitors (potassium cyanide, menadione, and promethazine) inhibit metabolite formation when N-methylnicotinamide is utilized as an ..
  65. ncbi Mitochondrial phospholipid hydroperoxide glutathione peroxidase plays a major role in preventing oxidative injury to cells
    M Arai
    School of Pharmaceutical Sciences, Kitasato University, 5 9 1 Shirokane, Minato ku, Tokyo 108, Japan
    J Biol Chem 274:4924-33. 1999
    ..Cell death caused by mitochondrial injury due to potassium cyanide (KCN) or rotenone (chemical hypoxia) was considerably suppressed in the M15 cells, whereas the L9 cells and ..
  66. ncbi Microglia in organotypic hippocampal slice culture and effects of hypoxia: ultrastructure and lipocortin-1 immunoreactivity
    G G Skibo
    Department of Cytology, Bogomoletz Institute of Physiology, 4 Bogomoletz Street, 252024, Kiev, Ukraine
    Neuroscience 96:427-38. 2000
    ..as activated and phagocytic cells that appeared in the slice after experimental toxic hypoxia induced by potassium cyanide treatment...
  67. ncbi Nitric oxide induces dose-dependent CA(2+) transients and causes temporal morphological hyperpolarization in human neutrophils
    V M Loitto
    Department of Medical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Cell Physiol 182:402-13. 2000
    ..e. D-penicillamine, glutathione, or potassium cyanide. Increasing doses of SNAP (>/=200 microM) attenuated the Ca(2+) response to the soluble chemotactic ..
  68. ncbi Melatonin in relation to cellular antioxidative defense mechanisms
    R J Reiter
    Department of Cellular and Structural Biology, University of Texas Health Science Center, USA
    Horm Metab Res 29:363-72. 1997
    ..melatonin was found to significantly inhibit oxidative damage that is a consequence of paraquat toxicity, potassium cyanide administration, lipopolysaccharide treatment, kainic acid injection, carcinogen administration, carbon ..
  69. pmc Purification of histidase from Streptomyces griseus and nucleotide sequence of the hutH structural gene
    P C Wu
    Department of Microbiology, Ohio State University, Columbus 43210 1292
    J Bacteriol 174:1647-55. 1992
    ..High concentrations of potassium cyanide inactivated histidase in the absence of its substrate or histidinol phosphate, suggesting that, as in other ..
  70. ncbi Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species
    Amos A Fatokun
    Institute of Biomedical and Life Sciences, Room 345, West Medical Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Eur J Pharmacol 587:35-41. 2008
    ..Cultures were resistant to mitochondrial poisoning by potassium cyanide, but succumbed to 24-h exposures to 3-nitropropionic acid (1 mM)...
  71. ncbi Prostaglandin f2alpha treatment in vivo, but not in vitro, stimulates protein kinase C-activated superoxide production by nonsteroidogenic cells of the rat corpus luteum
    R F Aten
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    Biol Reprod 59:1069-76. 1998
    ..inhibitor, diphenylene iodonium (ID50 = 5 microM for TPA), but not by the mitochondrial inhibitors, potassium cyanide, rotenone, or sodium azide. Fractionation of cells by centrifugal elutriation showed that TPA-stimulated O2-...
  72. ncbi Mechanical interactions among cytoskeletal filaments
    N Wang
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02115, USA
    Hypertension 32:162-5. 1998
    ..Inhibition of oxidative metabolism with potassium cyanide had no effects on stress-induced stiffening response...
  73. ncbi Activation of GABAA but not GABAB receptors in the NTSblocked bradycardia of chemoreflex in awake rats
    J C Callera
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900 Ribeirao Preto, Sao Paulo, Brazil
    Am J Physiol 276:H1902-10. 1999
    ..into the nucleus tractus solitarius (NTS) on bradycardic and pressor responses to chemoreflex activation (potassium cyanide, 40 micrograms/rat iv) in awake rats...
  74. ncbi Measuring the mitotic index in chemically-treated human lymphocyte cultures by flow cytometry
    P A Muehlbauer
    Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Mutat Res 537:117-30. 2003
    ..and flow MI frequencies from 24h treatments with mitomycin-C, aphidicolin, eugenol, etoposide, hydroxyrurea, potassium cyanide, staurosporine, ethyl alcohol, noscapine and colcemid((R)) are presented...
  75. ncbi Application of Klebsiella oxytoca immobilized cells on the treatment of cyanide wastewater
    C Y Chen
    Institute of Environmental Engineering, National Sun Yat Sen University, Kaohsiung 804, Taiwan
    Chemosphere 71:133-9. 2008
    ..In this study, potassium cyanide was used as the target compound and both alginate and cellulose triacetate techniques were applied for the ..
  76. ncbi Cholestatic hepatitis caused by acute gold potassium cyanide poisoning
    M L Wu
    Department of Medicine, Taipei Veterans General Hospital, National Yang Ming University, Taiwan
    J Toxicol Clin Toxicol 39:739-43. 2001
    Poisoning after oral ingestion of gold potassium cyanide is rarely reported. A case of suicidal ingestion of gold potassium cyanide (potassium dicyanoaurate; CAS# 13967-50-5) is described.
  77. ncbi P450-catalyzed vs. electrochemical oxidation of haloperidol studied by ultra-performance liquid chromatography/electrospray ionization mass spectrometry
    Tove Johansson Mali'n
    Discovery DMPK, AstraZeneca R and D Molndal, Sweden
    Rapid Commun Mass Spectrom 24:1231-40. 2010
    ..Liver microsomal incubations and electrochemical oxidation in the presence of potassium cyanide (KCN) resulted in two diastereomeric cyano adducts, proposed to be generated from trapping of the endocyclic ..
  78. ncbi Potentiating effect of an endocrine disruptor, paranonylphenol, on the generation of reactive oxygen species (ROS) in human venous blood -- association with the activation of signal transduction pathway
    Yasuji Okai
    Department of Human Life Science, Osaka Kun Ei Women s College, Sets City, Osaka 566 8501, Japan
    J UOEH 29:221-33. 2007
    ..effects on ROS generation induced by NP, but an inhibitor against mitochondrial respiratory function, potassium cyanide (KCN), did not exhibit a significant effect...
  79. ncbi Determination of cyanide in blood by isotope-dilution gas chromatography-mass spectrometry
    Karen E Murphy
    National Institute of Standards and Technology, Gaithersburg, MD 20899, USA
    Clin Chem 52:458-67. 2006
    ..We describe an automated procedure based on isotope-dilution gas chromatography-mass spectrometry (ID GC/MS) for the accurate and rapid determination of CN in whole blood...
  80. ncbi Assessing and minimizing time-dependent inhibition of cytochrome P450 3A in drug discovery: a case study with melanocortin-4 receptor agonists
    W Tang
    Department of Drug Metabolism and Pharmacokinetics, Merck Research Laboratories, Rahway, NJ 07065, USA
    Xenobiotica 38:1437-51. 2008
    ..In incubations fortified with potassium cyanide, a cyano adduct was identified by liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis as a ..
  81. ncbi Endothelin and mechanical properties of the carotid artery in Wistar-Kyoto and spontaneously hypertensive rats
    G Marano
    Laboratorio di Farmacologia, Istituto Superiore di Sanita, Rome, Italy
    Cardiovasc Res 41:701-7. 1999
    ..control conditions, as well as with those following complete abolition of vascular smooth muscle tone by potassium cyanide (KCN)...
  82. ncbi Structural and functional reconstruction in situ of the [CuSMoO2] active site of carbon monoxide dehydrogenase from the carbon monoxide oxidizing eubacterium Oligotropha carboxidovorans
    Marcus Resch
    Lehrstuhl fur Mikrobiologie, Bayreuther Zentrum für Molekulare Biowissenschaften, Universitat Bayreuth, 95440 Bayreuth, Germany
    J Biol Inorg Chem 10:518-28. 2005
    ..of mature and immature forms of CO dehydrogenase were converted into a [MoO(3)] centre by treatment with potassium cyanide. We have established a method, which rescues 50% of the CO dehydrogenase activity by in vitro reconstitution ..
  83. ncbi Purification and characterization of polyphenol oxidase from banana (Musa sapientum L.) pulp
    C P Yang
    Laboratory of Food Science, Faculty of Agriculture, Saga University, Saga 840 8502, Japan
    J Agric Food Chem 48:2732-5. 2000
    ..The enzyme activity was completely inhibited by L-ascorbic acid, cysteine, sodium diethyldithiocarbamate, and potassium cyanide. Under a low buffer capacity, the enzyme was also strongly inhibited by citric acid and acetic acid at 10 mM.
  84. ncbi Neurotransmission of the cardiovascular reflexes in the nucleus tractus solitarii of awake rats
    B H Machado
    Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, 14049 900, Ribeirao Preto, SP, Brazil
    Ann N Y Acad Sci 940:179-96. 2001
    Chemoreflex activation with potassium cyanide (i.v.) produces pressor and bradycardic responses in awake rats...
  85. ncbi Substrate-selective supramolecular tandem assays: monitoring enzyme inhibition of arginase and diamine oxidase by fluorescent dye displacement from calixarene and cucurbituril macrocycles
    Werner M Nau
    School of Engineering and Science, Jacobs University Bremen, Campus Ring 1, D 28759 Bremen, Germany
    J Am Chem Soc 131:11558-70. 2009
    ..e., S-(2-boronoethyl)-L-cysteine and 2(S)-amino-6-boronohexanoic acid for arginase and potassium cyanide for diamine oxidase...
  86. ncbi Prophylactic evaluation of recombinant extracellular superoxide dismutase of Brugia malayi in jird model
    Snehal Dabir
    Department of Biochemistry and J B Tropical Disease Research Center, Mahatma Gandhi Institute of Medical Sciences, Sevagram 442102, MS, India
    Vaccine 26:3705-10. 2008
    ..gel for SOD activity of the expressed recombinant protein revealed that SOD activity inactivated by potassium cyanide and hydrogen peroxide but not by sodium azide, indicating presence of Cu/Zn-SOD...
  87. ncbi Factors influencing nominal effective concentrations of chemical compounds in vitro: medium protein concentration
    H Seibert
    Institut für Experimentelle Toxikologie, Universitatsklinikum Kiel, Weimarer Str 8, Haus 3, D 24106 Kiel, Germany
    Toxicol In Vitro 16:289-97. 2002
    ..and absence of 4% (w/v) albumin varied between 500 (hexachlorophene), 258 (pentachlorophenol) and almost 1 (potassium cyanide, dextropropoxyphene). Calculated molar ratios of substance bound to albumin ranged from 0...
  88. pmc Near-infrared light via light-emitting diode treatment is therapeutic against rotenone- and 1-methyl-4-phenylpyridinium ion-induced neurotoxicity
    H L Liang
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Neuroscience 153:963-74. 2008
    ..light-emitting diode (LED) treatment was therapeutic to neurons functionally inactivated by tetrodotoxin, potassium cyanide (KCN), or methanol intoxication, and LED pretreatment rescued neurons from KCN-induced apoptotic cell death...
  89. ncbi Optimizing the procedure for mercury recovery from dental amalgam
    Flávia Godoy Iano
    School of Dentistry of Bauru, University of Sao Paulo, Bauru, SP, Brazil
    Braz Oral Res 22:119-24. 2008
    ..through exposure to direct flame (650 degrees C), long processing time, and hazardous reagents as potassium cyanide. The purpose of this study was to develop a method to replace the direct flame by an electrical mantle in ..
  90. ncbi In vitro and in vivo comparison of sulfur donors as antidotes to acute cyanide intoxication
    S I Baskin
    Pharmacology Division, US Army Medical Research Institute of Chemical Defence, Aberdeen Proving Ground, MD, USA
    J Appl Toxicol 19:173-83. 1999
    ..Separate studies suggest that the chemical reaction of potassium cyanide (KCN) and cystine forms the toxic metabolite 2-iminothiazolidine-4-carboxylic acid...
  91. pmc Effect of factor XIII on endothelial barrier function
    T Noll
    Physiologisches Institut, Justus Liebig Universitat, D 35392 Giessen, Germany
    J Exp Med 189:1373-82. 1999
    ..Hyperpermeability induced by metabolic inhibition (1 mM potassium cyanide plus 1 mM 2-deoxy-D-glucose) was prevented in the presence of the activated factor XIII A...
  92. pmc Alterations in membrane transport function and cell viability induced by ATP depletion in primary cultured rabbit renal proximal tubular cells
    Sung Ju Lee
    Department of Physiology, MRC for Ischemic Tissue Regeneration, College of Medicine, Pusan National University, Busan 602 739, Korea
    Korean J Physiol Pharmacol 13:15-22. 2009
    ..ATP depletion was induced by incubating cells with 2.5 mM potassium cyanide (KCN)/0...
  93. ncbi An electron spin resonance spin-trapping investigation of the free radicals formed by the reaction of mitochondrial cytochrome c oxidase with H2O2
    Y R Chen
    Laboratory of Pharmacology and Chemistry, NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    J Biol Chem 274:3308-14. 1999
    ..tyrosyl adduct(s). The inhibition of either CcO or NEM-CcO with potassium cyanide prevented detectable MNP adduct formation, indicating heme involvement in the reaction...
  94. ncbi A novel double heme substitution produces a functional bo3 variant of the quinol oxidase aa3 of Bacillus cereus. Purification and paratial characterization
    Martha Contreras-Zentella
    Instituto de Fisiologia Celular, Facultad de Medicina, and Instituto de Investigaciones Biomédicas, Universidad Nacional Autonoma de Mexico, Mexico City 04510, Mexico
    J Biol Chem 278:31473-8. 2003
    ..The quinol oxidase activity with tetrachlorohydroquinol was inhibited by potassium cyanide and 2-n-heptyl 4-hydroxyquinoline-N-oxide with an I50 of 24 and 300 microM, respectively...
  95. ncbi Inhibition of mitochondrial complex IV leads to secondary loss complex II-III activity: implications for the pathogenesis and treatment of mitochondrial encephalomyopathies
    I P Hargreaves
    Neurometabolic Unit, National Hospital and Department of Molecular Neuroscience, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Mitochondrion 7:284-7. 2007
    ..b>Potassium cyanide (KCN, 1mM) resulted in a sustained 50% (p<0.01) loss of complex IV...
  96. ncbi Inhibitory effect of bionic fungicide 2-allylphenol on Botrytis cinerea (Pers. ex Fr.) in vitro
    Shuangjun Gong
    Department of Plant Pathology, College of Agriculture and Biotechnology, China Agricultural University, Beijing 100193, People s Republic of China
    Pest Manag Sci 65:1337-43. 2009
    ..bark. 2-Allylphenol has been used in China for 10 years. However, its biochemical mode of action remains unclear. An in vitro study was conducted on the biochemical mechanism of 2-allyphenol inhibiting Botrytis cinerea (Pers. ex Fr.)...
  97. pmc Hydrogen peroxide generation by the pepper extracellular peroxidase CaPO2 activates local and systemic cell death and defense response to bacterial pathogens
    Hyong Woo Choi
    College of Life Sciences and Biotechnology, Korea University, Seoul 136 713, Republic of Korea
    Plant Physiol 145:890-904. 2007
    ..Arabidopsis leaves infected by Pseudomonas syringae pv tomato, H(2)O(2) generation was sensitive to potassium cyanide (a peroxidase inhibitor) but insensitive to diphenylene iodonium (an NADPH oxidase inhibitor), suggesting ..
  98. ncbi Acute cyanide poisoning among jewelry and textile industry workers
    Luís Coentrão
    Institute of Pharmacology and Therapeutics, University of Porto, Portugal
    Am J Emerg Med 29:78-81. 2011
    ..the study period, 8 (7 males, 1 female; age 36 ± 11 years, mean ± SD) attempted suicide by ingestion of potassium cyanide used in their profession as goldsmiths or textile industry workers...
  99. ncbi Determination of catecholamines in pheochromocytoma cell (PC-12) culture medium by microdialysis-microbore liquid chromatography
    F C Cheng
    Department of Medical Research, Taichung Veterans General Hospital, Taiwan
    J Chromatogr A 870:405-11. 2000
    ..29 ng/ml which was elevated to 2.43 ng/ml after treatment with 0.5 mM potassium cyanide. In conclusion, the present microassay provides for the sensitive, direct measurement of catecholamines in ..
  100. ncbi Cognitive improving and cerebral protective effects of acylated oligosaccharides in Polygala tenuifolia
    Yukinobu Ikeya
    Research Division, Tsumura and Co, Ibaraki, Japan
    Biol Pharm Bull 27:1081-5. 2004
    ..tenuifolia, showed the cerebral protective effect on potassium cyanide (KCN)-induced anoxia in mice, widely used as an animal model for cerebrovascular disease, and also had an ..
  101. ncbi Reactions of pholasin with peroxidases and hypochlorous acid
    S Reichl
    Institute of Medical Physics and Biophysics, School of Medicine, University of Leipzig, Leipzig, Germany
    Free Radic Biol Med 28:1555-63. 2000
    ..This is shown by the inhibition of luminescence with superoxide dismutase and potassium cyanide, together with the lack of effect of both methionine and taurine...

Research Grants14

  1. RNAi in DNA Sequence Elimination in Tetrahymena
    Martin A Gorovsky; Fiscal Year: 2010
    ..These studies should shed light on other RNAi- like processes that are important for normal development and maintenance of genome stability in multicellular organisms. ..
  2. Repeated Genes: Organization, Evolution, and Function
    MARTIN GOROVSKY; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  3. CONTROL OF GENE ACTIVITY AND ORGANELLE BIOGENESIS
    MARTIN GOROVSKY; Fiscal Year: 2006
    ..abstract_text> ..
  4. MOLECULAR TOXICOLOGY IN HUMAN KIDNEY CELLS
    Lawrence Lash; Fiscal Year: 2007
    ..Achievement of these aims should build on our previous work in human kidney cells and extend it to provide a much more complete understanding of the various and complex ways in which DCVC affects the human kidney [unreadable] [unreadable]..
  5. Supramedullary control of respiration
    Linda Hayward; Fiscal Year: 2007
    ..Furthermore, the results of this study will provide new insights into understanding of the role of supramedullary structures in modulating respiratory timing. [unreadable] [unreadable]..
  6. METABOLIC ORGANIZATION & REGULATION IN THE VISUAL CORTEX
    Margaret Wong Riley; Fiscal Year: 2002
    ..Results from these studies are expected to provide insight into the molecular basis of metabolic responses of visual cortical neurons to changing functional demands. ..
  7. 5-HT1A-agonist mediated recovery in hypovolemic shock
    Karie Scrogin; Fiscal Year: 2007
    ..We will also assess the ability of clinically available 5-HT1A agonists to delay the transition from hypovolemic shock to circulatory collapse. ..
  8. Mechanism and Assessment of Hypoxia-Induced Islet Death
    IAN SWEET; Fiscal Year: 2005
    ..abstract_text> ..
  9. GLUTATHIONE AND MITOCHONDRIA IN TOXIC RENAL INJURY
    Lawrence Lash; Fiscal Year: 2003
    ..This information may have therapeutic applications for prevention of renal cellular injury or for understanding mitochondrial diseases or age-related decreases that occur in mitochondrial function. ..
  10. Instrument to Measure Oxygen Affinity of Hemoglobin
    Kim Vandegriff; Fiscal Year: 2004
    ..abstract_text> ..
  11. PERIAQUEDUCTAL GRAY MODULATION OF SYMPATHETIC DRIVE
    Linda Hayward; Fiscal Year: 2002
    ..In the long term it is hoped that the results of these studies will stimulate new investigations into the role of the dlPAG, A5 and the PBN in normal and pathophysiological cardiovascular regulation. ..
  12. Neurochemical Organization of Brain Stem Respiratory Nuclei
    MARGARET TT WONG RILEY; Fiscal Year: 2010
    ....
  13. MITOCHONDRIA AND PULMONARY ENDOTHELIAL CELL DEATH
    James Peterson; Fiscal Year: 2007
    ..abstract_text> ..
  14. Cyanide-induced Neurotoxicity: Molecular Death Signaling
    Gary Isom; Fiscal Year: 2008
    ..This study will provide valuable insight into neurotoxicant-induced neurodegeneration and fundamental information on regulation of cell death in the CNS. ..