Genomes and Genes
Summary: Potassium chloride. A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.
Publications232 found, 100 shown here
- DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulationKeri Martinowich
Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
Science 302:890-3. 2003..Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity...
- Salt dependence of ion transport and DNA translocation through solid-state nanoporesRalph M M Smeets
Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
Nano Lett 6:89-95. 2006..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM...
- Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cordC Morgado
Faculty of Medicine of Porto and IBMC, Institute of Histology and Embryology, University of Porto, Alameda Prof Hernani Monteiro, Porto, Portugal
Diabetes Obes Metab 13:150-9. 2011..during mechanical hyperalgesia induced by diabetes may result from a decrease in the local expression of the potassium chloride co-transporter 2 (KCC2), which shifts the action of the neurotransmitter γ-amminobutiric acid (GABA) from ..
- Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NOVikas Kapil
William Harvey Research Institute, Barts and London Medical School, Queen Mary University of London, London, UK
Hypertension 56:274-81. 2010....
- The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchiolesJose F Perez
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Gen Physiol 125:535-53. 2005....
- Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulusPaul H Ratz
Virginia Commonwealth Univ, School of Medicine, Dept of Biochemistry, 1101 E Marshall St, PO Box 980614, Richmond, VA 23298 0614, USA
Am J Physiol Cell Physiol 288:C769-83. 2005..KCl as a "simple" stimulus promises to remain a standard tool for smooth muscle cell physiologists, whose focus is to understand mechanisms regulating Ca2+ sensitivity...
- Use of potassium chloride and flavor enhancers in low sodium Cheddar cheeseJ Grummer
Department of Food Science and Nutrition, University of Minnesota, St Paul MN 55108, USA
J Dairy Sci 96:1401-18. 2013We investigated use of potassium chloride (KCl) to maintain both the salty flavor and to replace the preservative effects of salt when reducing the sodium content in natural cheese...
- Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contractionSotaro Sakurada
Department of Physiology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
Circ Res 93:548-56. 2003..Taken together, these results indicate the existence of the thus-far unrecognized Ca2+-dependent Rho stimulation mechanism in VSM. Excitatory receptor agonists are suggested to use this pathway for simulating Rho...
- Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295ROsamu Akizuki
Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Shizuoka 411 8731, Japan
Eur J Pharmacol 584:424-34. 2008..T-type Ca2+ channels may contribute to additional benefits of this drug for treating renal and cardiovascular diseases, beyond its primary anti-hypertensive effects from blocking L-type Ca2+ channels...
- Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2Wen G Chen
Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Science 302:885-9. 2003..These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T...
- Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranesL Pickard
MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
Neuropharmacology 41:700-13. 2001..Our data indicate that the transient synaptic activation of NMDARs can lead to the insertion of native AMPARs at sites on the neuronal membrane that initially lacks AMPARs...
- IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscleOmar Tliba
Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
Br J Pharmacol 140:1159-62. 2003..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
- Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilationMin Liang Si
Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Ill 62794 9629, USA
Circ Res 91:62-9. 2002..Endogenous choline may play an important role in regulating cerebral sympathetic activity and vascular tone...
- A biochemical and molecular characterization of LEP1, an extensin peroxidase from lupinNicholas J Price
Instituto de Tecnologia Quimica e Biologica, Apartado 127, 2781 901 Oeiras, Portugal
J Biol Chem 278:41389-99. 2003..Comparative modeling of the translated sequence indicated an unusually unobstructed equatorial cleft across the substrate access channel, which might facilitate interaction with extensin and confer higher EP activity...
- Depolarization induces acetylation of histone H2B in the hippocampusC Maharana
National Brain Research Centre, Manesar, Haryana 122050, India
Neuroscience 167:354-60. 2010..These results show that acetylation of histone H2B is regulated in an activity-dependent manner by the molecular events important for synaptic plasticity and memory...
- Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth musclesM Yoshida
Department of Urology, Kumamoto University School of Medicine, 1 1 1 Honjo, 860 8556, Kumamoto, Japan
Exp Gerontol 36:99-109. 2001..The age-related changes in neurotransmissions may contribute to the changes in bladder function in the elderly...
- Recruitment of smooth muscle cells and arterial vasomotionMathieu Lamboley
Cellular Biophysics and Biomechanics Laboratory, Swiss Federal Institute of Technology, SG AA B 1 44, CH 1015 Lausanne, Switzerland
Am J Physiol Heart Circ Physiol 285:H562-9. 2003..We conclude that the number of simultaneously recruited cells is an important factor in controlling rat mesenteric artery contraction and vasomotion...
- Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensivesFeng J He
Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
Hypertension 55:681-8. 2010..supplementation on endothelial function, cardiovascular risk factors, and bone turnover and to compare potassium chloride with potassium bicarbonate, we carried out a 12-week randomized, double-blind, placebo-controlled crossover ..
- Manufacture of low-sodium Minas fresh cheese: effect of the partial replacement of sodium chloride with potassium chlorideA P Gomes
Universidade de Taubate, Curso de Engenharia de Alimentos, Estrada Municipal Dr José Luis Cembranelli, 5000, Fazenda Piloto, Itaim, Taubate, Sao Paulo, Brasil CEP12081 010
J Dairy Sci 94:2701-6. 2011We investigated the effect of sodium reduction by partial substitution of sodium chloride (NaCl) with potassium chloride (KCl) on the manufacture of Minas fresh cheese during 21 d of refrigerated storage...
- Rho-kinase inhibition suppresses potassium chloride-induced bladder hyperactivity in a rat modelMahadevan Rajasekaran
Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
Urology 69:791-4. 2007..In the present study, we tested our hypothesis that potassium chloride (KCl)-induced bladder hyperactivity might be mediated through a calcium-sensitizing RhoA-Rho-kinase pathway ..
- KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinaseLuke J Janssen
Asthma Research Group, Firestone Institute for Respiratory Health, Saint Joseph s Hospital, Hamilton, Ontario, L8N 4A6, Canada
Am J Physiol Lung Cell Mol Physiol 287:L852-8. 2004..KCl-induced elevation of [Ca2+]i was not affected by Y-27632 but was reversed by NiCl2 or by BAPTA-AM. We conclude that KCl acts in part through stimulation of Rho and ROCK, possibly secondary to voltage-dependent Ca2+ influx...
- Management of a case of uterine scar pregnancy by transabdominal potassium chloride injectionJ Hartung
Ultrasound Obstet Gynecol 21:94-5. 2003
- Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivoY Matsuka
Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA
Brain Res 915:248-55. 2001..Robust ATP release was evoked with 5 microM capsaicin. These data suggest that ATP is released concurrently with SP from the somata of neurons within sensory ganglia...
- p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neuronsHuan Ling Liang
Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
J Neurosci Res 88:640-9. 2010..Our results indicate that both p38 MAPK and calcium play important roles in mediating signaling in depolarization-induced activation of PGC-1alpha at the protein and message levels in neurons...
- Fatal intravenous injection of potassium in hospitalized patientsAngela R Wetherton
Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Kentucy, USA
Am J Forensic Med Pathol 24:128-31. 2003..These cases illustrate the subtlety of findings in such deaths and remind the forensic pathologist to consider this type of event in sudden, unexpected death of hospitalized patients...
- Suppression of endogenous PPARγ increases vulnerability to methamphetamine-induced injury in mouse nigrostriatal dopaminergic pathwaySeong Jin Yu
National Institute on Drug Abuse, IRP, Neural Protection and Regeneration Section, 251 Bayview Boulevard, 06 721A, Baltimore, MD 21224, USA
Psychopharmacology (Berl) 221:479-92. 2012..Previous studies have shown that pretreatment with peroxisome proliferator-activated receptor gamma (PPARγ) agonist reduced methamphetamine-induced neurodegeneration...
- Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileumSeigo Fujimoto
Department of Cellular and Molecular Pharmacology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Japan
Eur J Pharmacol 530:144-51. 2006..The relaxation could be explained by a decrease in phosphorylation of MLC(20)...
- Medication errors: inadvertent administration of potassium chlorideS L Emmett
Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University
J Law Med 11:146-7. 2003
- Potassium chloride supplementation alone may not improve hypokalemia in thyrotoxic hypokalemic periodic paralysisTsuan Shih Yu
Division of Nephrology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
J Emerg Med 32:263-5. 2007..He was found to have severe hypokalemia, with K(+) level at 1.7 mmol/L. However, after administration of potassium chloride (KCl), 10 mEq/h intravenous (i.v.) drip for 4 h, follow-up serum potassium was even lower at 1...
- Application of potassium chloride to a Chernobyl-contaminated lake: modelling the dynamics of radiocaesium in an aquatic ecosystem and decontamination of fishJames T Smith
Centre for Ecology and Hydrology, Winfrith Technology Centre, Dorchester, DT2 8ZD, Dorset, UK
Sci Total Environ 305:217-27. 2003..In February 1998 we applied 15 t of potassium chloride to Lake Svyatoe, Kostiukovichy...
- The effect of cardioplegic solution-induced sodium concentration fluctuation on postoperative seizure in pediatric cardiac patientsJin Tae Kim
Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea
Ann Thorac Surg 91:1943-8. 2011..We evaluated the relationship between the cardioplegic solution, the fluctuation of sodium concentration, and the incidence of postoperative seizure in pediatric cardiac patients...
- Intravenous potassium chloride prescribing and administration practices in Victoria: an observational studyMelita A Van de Vreede
Pharmacy Department, Bayside Health, Melbourne, Vic, Australia
Med J Aust 189:575-7. 2008To identify current prescribing and administration practices in relation to intravenous potassium chloride (IV KCl).
- KCl potentiates forskolin-induced PC12 cell neurite outgrowth via protein kinase A and extracellular signal-regulated kinase signaling pathwaysThomas V O Hansen
Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, DK 2100, Copenhagen, Denmark
Neurosci Lett 347:57-61. 2003..The results demonstrate that PKA and ERK play a key role in KCl- and forskolin-induced neuronal differentiation by integration of signals from both pathways...
- The role of potassium chloride cotransporters in murine and human sperm volume regulationT Klein
Institute of Reproductive Medicine, University of Munster, D 48129 Munster, Germany
Biol Reprod 75:853-8. 2006..Therefore, besides organic osmolyte efflux and KCl release through separate K(+) and Cl(-) ion channels, SLC12A7 also is involved in murine but not human sperm RVD mechanisms...
- Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivityYao Chi Chuang
Division of Urology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
Urology 61:664-70. 2003..animal model for hyperactive bladder in rats was developed using intravesical infusion of protamine sulfate (PS), an agent thought to break down urothelial barrier function, and physiologic concentrations of potassium chloride (KCl).
- Improving outcome of treatment of kala-azar by supplementation of amphotericin B with physiologic saline and potassium chlorideChandeshwar P Thakur
Balaji Utthan Sansthan, Patna, India
Am J Trop Med Hyg 83:1040-3. 2010....
- Upregulation by KCl treatment of eukaryotic translation elongation factor 1A (eEF1A) mRNA in the dendrites of cultured rat hippocampal neuronsIl Soo Moon
Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 780 714, Korea
Mol Cells 25:538-44. 2008..These results indicate that KCl treatment increases both the density of eEF1A mRNA clusters and their synaptic association in dendrites of cultured neurons...
- Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neuronsIl Soo Moon
Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 780 714, Korea
Exp Mol Med 41:601-10. 2009..This provides a potential mechanism by which protein translation at synapses may be enhanced in response to synaptic stimulation...
- Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transferLiming Ying
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
Proc Natl Acad Sci U S A 100:14629-34. 2003..The unfolding free energy barrier is estimated to be between 3 and 15 kBT based on Kramers' theory. We conclude that under near-physiological conditions these structures coexist and can interconvert on a minute time scale...
- On the value of c: can low affinity systems be studied by isothermal titration calorimetry?W Bruce Turnbull
Astbury Centre for Structural Molecular Biology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
J Am Chem Soc 125:14859-66. 2003..Therefore, isothermal titration calorimetry is a valid and useful technique for studying biologically and synthetically important low affinity systems...
- The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neuronsS Yasuda
Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
Mol Psychiatry 14:51-9. 2009..Our results have strong implications for the therapeutic actions of these two mood stabilizers...
- Activity-induced targeting of profilin and stabilization of dendritic spine morphologyManuel Ackermann
Friedrich Miescher Institute, Box 2543, 4002 Basel, Switzerland
Nat Neurosci 6:1194-200. 2003..These results suggest that, in addition to electrophysiological changes, NMDA receptor activation initiates changes in the actin cytoskeleton of dendritic spines that stabilize synaptic structure...
- The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated mannerHenrike Neuhoff
Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
Eur J Neurosci 21:15-25. 2005..These results show that profilin I can be present at both pre- and postsynaptic sites and suggest a role for this actin-binding protein in activity-dependent remodelling of synaptic structure...
- Tumor necrosis factor-alpha triggers cell death of sensitized potassium chloride-stimulated cholinergic neuronsBirgit Zassler
Laboratory of Psychiatry, Department of Psychiatry, University Hospital Innsbruck, Anichstr 35, Austria
Brain Res Mol Brain Res 113:78-85. 2003..When co-slices of basal nucleus of Meynert and neocortex were sensitized for 15 min with 30 mM potassium chloride and subsequently incubated for 1 week with 20 ng/ml TNF-alpha, cholinergic neurons and nerve fibers markedly ..
- Role of Rho-kinase in mediating contraction of chicken embryo femoral arteriesBea Zoer
Department of Pediatrics, Maastricht University Medical Centre, School for Oncology and Developmental Biology GROW, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
J Comp Physiol B 180:427-35. 2010..In summary, our findings are indicative of a role for Rho-kinase activity in depolarization- and agonist-induced force generation in chicken embryo femoral arteries...
- Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampusGiambattista Bonanno
Section of Pharmacology and Toxicology, Department of Experimental Medicine, and Center of Excellence for Biomedical Research, University of Genoa, 16148 Genoa, Italy
J Neurosci 25:3270-9. 2005....
- Sustained-release potassium chloride overdoseM Su
New York City Poison Control Center, NYU Bellevue Hospital Center, Department of Emergency Medicine, New York 10016, USA
J Toxicol Clin Toxicol 39:641-8. 2001..We report 2 cases of hyperkalemia in patients with normal renal function who developed hyperkalemia after ingesting sustained-release potassium preparations and describe the use of radiography and whole-bowel irrigation in their care...
- Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and EosJianxin Bao
Department of Otolaryngology, Washington University, St Louis, Missouri 63110, USA
Nat Neurosci 7:1250-8. 2004..This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity...
- The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometriumS Kupittayanant
Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
Pflugers Arch 443:112-4. 2001..This suggests that the Rho-A-ROK pathway may not be a potent modulator of force in the human myometrium under physiological conditions...
- Enhanced force generation by corpus cavernosum smooth muscle in rabbits with partial bladder outlet obstructionShaohua Chang
Division of Urology, Department of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA
J Urol 167:2636-44. 2002..We determined whether corpus cavernosum smooth muscle from rabbits with partial bladder outlet obstruction show any molecular or functional differences versus controls...
- Clinical review: Thyrotoxic periodic paralysis: a diagnostic challengeAnnie W C Kung
Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
J Clin Endocrinol Metab 91:2490-5. 2006..The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP)...
- The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeonR O'BRIEN
Department of Biochemistry and Molecular Biology, University College London, UK
J Mol Biol 279:117-25. 1998..Isothermal titration calorimetric binding studies were performed under a range of salts (potassium chloride, potassium phosphate, potassium acetate and sodium acetate) at varying concentrations (0.8 to 1.6 M)...
- Enthalpy and heat capacity changes for the proton dissociation of various buffer components in 0.1 M potassium chlorideH Fukada
Laboratory of Biophysical Chemistry, College of Agriculture, Osaka Prefecture University, Sakai, Japan
Proteins 33:159-66. 1998..1 M potassium chloride at temperatures ranging from 5 to 45 degrees C...
- Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slicesJean Christophe Corvol
Signal Transduction and Plasticity in the Nervous System Unit, INSERM Université Pierre et Marie Curie U536, Institut du Fer a Moulin, 75005 Paris, France
J Biol Chem 280:660-8. 2005....
- The formation pathway of tetramolecular G-quadruplexesCaroline Bardin
Laboratoire de Chimie et Biologie Structurale, Institut de Chimie des Substances Naturelles, Gif sur Yvette, 91190, France
Nucleic Acids Res 36:477-88. 2008....
- The effect of salts on the activity and stability of Escherichia coli and Haloferax volcanii dihydrofolate reductasesDonna B Wright
School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4460, USA
J Mol Biol 323:327-44. 2002..In support of this conclusion, all three DHFRs are similarly stabilized by the non-ionic cosolute, sucrose...
- Swelling behavior of the tomato cell wall networkA J MacDougall
Food Biopolymer Section, Institute of Food Research, Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA, U K
Biomacromolecules 2:450-5. 2001..Conditions were chosen to include those that would be encountered in vivo. Swelling in these systems was strongly influenced by the polyelectrolyte nature of the polymer and the extent of cross-linking with divalent counterions...
- Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladderFrederick J Ehlert
Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
J Pharmacol Exp Ther 322:631-7. 2007....
- In vitro and in vivo evaluation of potassium chloride sustained release formulation prepared with saturated polyglycolyed glycerides matricesPao Chu Wu
College of Pharmacy, Kaohsiung Medical University, No 100 Shih Chen 1st R D, Kaohsiung 807, Taiwan, ROC
Int J Pharm 243:119-24. 2002The aim of the present work was to evaluate the effect of sustained release of potassium chloride semi-solid matrices prepared with different kinds and added amounts of Gelucires by the in vitro dissolution test and in vivo oral ..
- 2-Aminoethoxydiphenyl borate inhibits KCl-induced vascular smooth muscle contractionPaul H Ratz
Department of Biochemistry, Virginia Commonwealth University, School of Medicine, Richmond, 23298 0614, USA
Eur J Pharmacol 541:177-83. 2006..These data support the conclusion that membrane depolarization activates 2-APB-sensitive TRPs in addition to VOCs to permit strong force-maintenance in tonic vascular smooth muscle...
- Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictorsPia Agren
Department of Pediatrics, Maastricht University Hospital, Research Institute Growth and Development GROW, University of Maastricht, Maastricht, The Netherlands
Am J Physiol Regul Integr Comp Physiol 292:R485-96. 2007....
- Effects of sex and estrogen on chicken ductus arteriosus reactivityThijs W H Flinsenberg
Department of Pediatrics, Maastricht University Medical Center, GROW School for Oncology and Developmental Biology, P Debyelaan 25, Maastricht, The Netherlands
Am J Physiol Regul Integr Comp Physiol 298:R1217-24. 2010..The estrogen 17beta-estradiol induces an endothelium-independent relaxation of chicken DA that is not mediated by ER activation. This relaxant effect is, at least partially, due to inhibition of Ca(2+) entry from extracellular space...
- Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovaniBenu Brata Das
Department of Molecular Parasitology, Indian Institute of Chemical Biology 4, Raja S C Mullick Road, Kolkata 700032, India
FEBS Lett 565:81-8. 2004..Interaction between the two subunits leading to the formation of an active complex could be explored as an insight for development of new therapeutic agents with specific selectivity...
- Acid-base effects of a bicarbonate-balanced priming fluid during cardiopulmonary bypass: comparison with Plasma-Lyte 148. A randomised single-blinded studyT J Morgan
Department of Anaesthesia, Princess Alexandra Hospital, Brisbane, Queensland, Australia
Anaesth Intensive Care 36:822-9. 2008..These are likely to be gluconate and/or acetate. Whether surges of exogenous anions during bypass can be harmful requires further study...
- The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomeraseSomdeb BoseDasgupta
Department of Molecular Parasitology, Indian Institute of Chemical Biology, Kolkata 700032, India
Mol Microbiol 67:31-46. 2008..Therefore this study helps in a better understanding of the mechanistic details underlying topoisomerization by this bi-subunit enzyme...
- Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinaseWu Bing
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
Am J Physiol Renal Physiol 285:F990-7. 2003..These results suggest that the ROK-mediated pathway is partly responsible for the high degree of force maintenance and slow relaxation in the detrusor from DB...
- Quaternary ammonium salt derivative of haloperidol inhibits KCl-induced calcium increase in rat aortic smooth muscle cellsG G Shi
Department of Pharmacology, Shantou University Medical College, Shantou 515031, China
Acta Pharmacol Sin 22:837-40. 2001..To study the effect of quaternary ammonium salt derivative of haloperidol (F3) on intracellular calcium (Ca2+) dynamic change in vascular smooth muscle cells (VSMC)...
- Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2Henry H C Lee
Department of Neuroscience, School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA
J Biol Chem 282:29777-84. 2007The potassium chloride cotransporter KCC2 plays a major role in the maintenance of transmembrane chloride potential in mature neurons; thus KCC2 activity is critical for hyperpolarizing membrane currents generated upon the activation of ..
- Stress-specific role of fission yeast Gcn5 histone acetyltransferase in programming a subset of stress response genesAnna Johnsson
School of Life Sciences, Södertörns högskola, SE 141 89 Huddinge, Sweden
Eukaryot Cell 5:1337-46. 2006....
- Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantroleneGennady Cherednichenko
Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
Mol Pharmacol 73:1203-12. 2008..The inhibitory potency of dantrolene on ECCE found in wild-type and MH-susceptible muscle is consistent with the drug's clinical potency for reversing the MH syndrome and is incomplete as predicted by its efficacy as a muscle relaxant...
- Intravitreous injection of a membrane depolarization agent causes retinal degeneration via matrix metalloproteinase-9Raghuveer S Mali
Eye Research Institute of Oakland University, Rochester, MI 48309, USA
Invest Ophthalmol Vis Sci 46:2125-32. 2005..In this study, KCl, a classic membrane depolarizing agent, was injected into the vitreous humor, and the role of matrix metalloproteinase (MMP)-9 in KCl-induced retinal damage was investigated...
- Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneitySaurabh Gupta
Department of Pharmacology, University Medical Center Rotterdam, The Netherlands
Eur J Pharmacol 530:107-16. 2006....
- Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and functionBart G J Dekkers
Department of Molecular Pharmacology, University Centre for Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
Am J Physiol Lung Cell Mol Physiol 292:L1405-13. 2007..Our results indicate that ECM proteins differentially regulate both phenotype and function of intact ASM...
- Kinesin tail domains and Mg2+ directly inhibit release of ADP from head domains in the absence of microtubulesDavid D Hackney
Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Biochemistry 47:7770-8. 2008..Tail domains only weakly inhibit the initial slow release of Mg (2+) from the kinesin-MgADP complex but strongly inhibit the fast release of Mg (2+)-free ADP...
- o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cellsMinseok Song
Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
Cell Signal 20:94-104. 2008..Here, we report that potassium chloride-induced depolarization provokes the activation of OGT and subsequent o-GlcNAcylation of proteins in ..
- The contraction of smooth muscle cells of intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KClJose F Perez
Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
J Gen Physiol 125:555-67. 2005..We hypothesize that the magnitude of the sustained intrapulmonary SMC contraction is determined by the frequency of Ca(2+) oscillations and also by the relaxation rate of the SMC...
- Ability of thrombin to act as molecular chaperone, inducing formation of quadruplex structure of thrombin-binding aptamerEva Baldrich
Department of Chemical Engineering, Universitat Rovira Virgili, Avinguda Paisos Catalans 26, 43007 Tarragona, Spain
Anal Biochem 341:194-7. 2005
- Robust axonal sprouting and synaptogenesis in organotypic slice cultures of rat cerebellum exposed to increased potassium chlorideSuzanne Chen
Department of Otolaryngology and Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
Brain Res 1057:88-97. 2005....
- Gender-related neuronal and smooth muscle damage of guinea pig isolated urinary bladder from anoxia-glucopenia and reperfusion injury and its relationship to glycogen contentFederica Pessina
Dipartimento di Scienze Biomediche, Universita di Siena, Siena, Italy
Neurourol Urodyn 26:416-23. 2007..To investigate the effects of anoxia and glucopenia (A-G) on both male and female guinea pig urinary bladder...
- Role of Rho-kinase in maintaining airway smooth muscle contractile phenotypeReinoud Gosens
Department of Molecular Pharmacology, University Centre for Pharmacy, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
Eur J Pharmacol 483:71-8. 2004..Rho-kinase is, however, a major regulator involved in the basal maintenance of contractility in bovine tracheal smooth muscle...
- Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol?Elfaridah P Frazier
Department of Pharmacology and Pharmacotherapy, University of Amsterdam, Academisch Medisch Centrum, The Netherlands
J Pharmacol Exp Ther 313:260-7. 2005..We conclude that cAMP and cGMP each play a minor role in beta-adrenergic receptor-mediated relaxation against passive tension, and calcium-dependent potassium channels play a minor role against active tension...
- Successful management of a heterotopic Caesarean scar pregnancy: potassium chloride injection with preservation of the intrauterine gestation: case reportL J Salomon
Service de Gynecologie Obstetrique, Hopital Antoine Beclere, Assistance Publique Hopitaux de Paris AP HP, 157 rue de la Porte de Trivaux, 92140 Clamart, France
Hum Reprod 18:189-91. 2003..We report the first case of CSP associated with a normal intrauterine pregnancy. Potassium chloride administered under transvaginal ultrasonographic guidance terminated cardiac activity in the CSP...
- Involvement of bidirectional adenosine transporters in the release of L-[3H]adenosine from rat brain synaptosomal preparationsJ G Gu
Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
J Neurochem 64:2105-10. 1995..abstract truncated at 250 words)..
- Maternal complication of cervical heterotopic pregnancy after successful potassium chloride fetal reductionCynthia Gyamfi
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
Fertil Steril 82:940-3. 2004To present a case of maternal morbidity encountered in a cervical heterotopic pregnancy after successful potassium chloride (KCl) injection for transvaginal multifetal pregnancy reduction.
- Inadequate anaesthesia in lethal injection for executionLeonidas G Koniaris
DeWitt Daughtry Family Department of Surgery, School of Business, University of Miami, Miami, FL, USA
Lancet 365:1412-4. 2005..Lethal injection is usually done by sequential administration of thiopental, pancuronium, and potassium chloride. Protocol information from Texas and Virginia showed that executioners had no anaesthesia training, drugs ..
- Contribution of Rho-kinase in human gallbladder contractionsKansu Buyukafsar
Department of Pharmacology, Medical Faculty, Mersin University, Campus Yenişehir 33169 Mersin, Turkey
Eur J Pharmacol 540:162-7. 2006..10(-8) M), histamine (10(-5) M), neurokinin A (10(-7)-10(-6) M), 5-hydroxytryptamine (10(-6)-10(-5) M) and potassium chloride (KCl, 25-50 mM)-induced contractions as well as spontaneous contractile activity...
- Rad52 protein has a second stimulatory role in DNA strand exchange that complements replication protein-A functionJames H New
Section of Microbiology, University of California, Davis, California 95616, USA
J Biol Chem 277:26171-6. 2002..We propose that Rad52 protein acts by stabilizing the Rad51 presynaptic filament...
- Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureterAdnan Levent
Department of Pharmacology, Medical Faculty, Mersin University Campus, Yenişehir 33169, Mersin, Turkey
Br J Pharmacol 143:431-7. 2004..Since Y-27632 and fasudil depressed the contractions, it seems plausible to postulate that Rho-kinase inhibitors may be beneficial in the treatment of renal colic...
- Multiple mechanisms of transmitter release evoked by "pathologically" elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calciumLuca Raiteri
Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genova, Genova, Italy
J Neurochem 80:706-14. 2002..These include carrier-mediated release and internal Ca2+-dependent exocytosis; in the latter, mitochondrial Ca2+ seems to play a primary role...
- Matrix-degrading enzymes tissue plasminogen activator and matrix metalloprotease-3 in the hypothalamo-neurohypophysial systemSeiji Miyata
Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, Japan
Brain Res 1058:1-9. 2005....
- Calcium channels coupled to glutamate release identified by omega-Aga-IVAT J Turner
Department of Physiology, Tufts University School of Medicine, Boston, MA 02111
Science 258:310-3. 1992..A presynaptic calcium channel important in glutamate release is shown to be omega-Aga-IVA sensitive and omega-conotoxin resistant...
- Risk of surgery after use of potassium chloride for treatment of tubal heterotopic pregnancyJerald S Goldstein
Department of Obstetrics and Gynecology, Washington University, St Louis, MO 63108, USA
Obstet Gynecol 107:506-8. 2006..physicians have attempted treatment of heterotopic pregnancies with minimally invasive procedures such as transvaginal guided potassium chloride (KCl) injection. However, there are few data on the success of this treatment.
- Computer modeling reveals that modifications of the histone tail charges define salt-dependent interaction of the nucleosome core particlesYe Yang
School of Biological Sciences, Nanyang Technological University, Singapore
Biophys J 96:2082-94. 2009..A more detailed description of the NCP did not change the main features of the results. Overall, the results of this work are in agreement with experimental data reported for NCP solutions and for chromatin arrays...
- Potent inhibition by tamoxifen of spontaneous and agonist-induced contractions of the human myometrium and intramyometrial arteriesA Kostrzewska
Institute of Obstetrics and Gynaecology, Medical Academy, Bialystok, Poland
Am J Obstet Gynecol 176:381-6. 1997..Our purpose was to elucidate the mechanism of direct (nongenomic) action of antiestrogens on spontaneous and agonist-induced contractions of the human myometrium and uterine arteries...
- Rapid release of Mg(2+) from liver mitochondria by nonesterified long-chain fatty acids in alkaline mediaPeter Schonfeld
Institute of Biochemistry, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
Arch Biochem Biophys 403:16-24. 2002..It is hypothesized that fatty acids activate an intrinsic Mg(2+)/H(+) exchanger that is related to, or identical with, the K(+)/H(+) exchanger...
- Effects of idarubicin and idarubicinol on rat coronary resistance and vasoconstrictor responsiveness of isolated aorta and mesenteryMichael Weiss
Section of Pharmacokinetics, Martin Luther University Halle Wittenberg, Halle, Germany
Anticancer Drugs 17:69-74. 2006..The correlation between the increase in coronary resistance and the decrease in vasoconstrictor responsiveness may suggest that these anthracyclines act through a common cellular mechanism...
- Characterization of four different effects elicited by H2O2 in rat aortaJosé Gil-Longo
Department of Pharmacology, Faculty of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
Vascul Pharmacol 43:128-38. 2005....
- Induces vasodilatation of rat mesenteric artery in vitro mainly by inhibiting receptor-mediated Ca(2+)-influx and Ca(2+)-releaseYong xiao Cao
Department of Pharmacology, Medical School of Xi an Jiaotong University, No 76, Yanta West Road, Xi an, Shaanxi Province 710061, P R China
Arch Pharm Res 28:709-15. 2005..Our results suggest that atropine-induced vasodilatation is mainly from artery smooth muscle cells due to inhibition of the receptor-mediated Ca(2+)-influx and Ca(2+)-release, and partly from the endothelium mediated by EDHF...
- Phenotypic modifications of vascular smooth muscle cells could be responsible for vascular hyporeactivity to contracting agent in mechanically injured rat carotid arteryA Popolo
Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
Atherosclerosis 183:213-21. 2005....
- Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aortaSilvana Morello
Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
Life Sci 78:825-30. 2006....
- The cardiovascular depression caused by bee venom in Sprague-Dawley rats associated with a decrease of developed pressure in the left ventricular and the ratio of ionized calcium/ionized magnesiumHyung Sub Kang
Department of Pharmacology and Toxicology, College of Veterinary Medicine, Bio Safety Research Institute, Chonbuk National University, Center for the Healthcare Technology Development, Jeonju 561 756, Republic of Korea
Am J Chin Med 36:505-16. 2008..These results suggest that BV induces cardiovascular depression by decreasing the cardiac pressure and increasing the ionized magnesium concentration in the blood...
- Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporteAYLIN RACHEL RODAN; Fiscal Year: 2013..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
- Transcriptional Regulation of Natriuetic Sensitivity in Diabetes MellitusPATIENCE O OBIH; Fiscal Year: 2012..as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-potassium chloride cotransporter (NKCC), respectively...
- Inhibition of chloride secretion by cigarette smokeJAMES LEVIN KREINDLER; Fiscal Year: 2010..End of Abstract) ..
- Bronchodilator Effects of Toll-Like Receptor-7 Agonists.David B Jacoby; Fiscal Year: 2011..by methacholine, histamine, stimulation of parasympathetic nerves, and depolarization of smooth muscle by potassium chloride. Pharmacological studies using TLR7 antagonists, as well as studies in TLR7- deficient mice, demonstrate ..
- CELLULAR ELECTROPHYSIOLOGY OF THE SUPRACHIASMATIC NUCLEICharles N Allen; Fiscal Year: 2011..4) Examine the role of different KCC cotransporters in regulating the intracellular Clconcentration and GABA responses of SCN neurons. ..
- CELLULAR ELECTROPHYSIOLOGY OF THE SUPRACHIASMATIC NUCLEICharles N Allen; Fiscal Year: 2013..4) Examine the role of Cl- efflux as regulated by KCC cotransporters in modulating the magnitude and polarity of GABAA receptor-mediated synaptic transmission. ..
- HORMONAL CONTROL OF UTERINE MUSCLE K-CHANNEL MRNAMary Boyle; Fiscal Year: 1992..Finally, the effect of suppressing translation of the K channel mRNA on the transformation of electrical properties by estrogen will be examined using hybrid-arrest techniques in myometrial cells treated with estrogen in vitro...
- PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITIONCHARLES STIER; Fiscal Year: 2003..We will also examine the interrelationship between mineralocorticoids and increased potassium chloride intake...
- MECHANISM OF THE NA, K- ION TRANSPORT ATPASERobert Post; Fiscal Year: 1990..The reactivity of the radioactive phosphoenzyme will be assessed by its response to adenosine diphosphate or potassium chloride added during a chase of unlabeled adenosine triphosphate...
- STUDY OF HUMAN MULTIPLE MYELOMA CELL ANTIGENSMalcolm MacKenzie; Fiscal Year: 1980..Antigens will be isolated and characterized by means of potassium chloride extraction gel chromatography, ion exchange chromatography and polyacrylamide gel electrophoresis...
- MECHANISMS OF HUMAN CORONARY ARTERIOLAR DILATIONDavid Gutterman; Fiscal Year: 2001..However, presence of potassium chloride does prevent flow-mediated dilation...
- Sciatic ligation, spinal plasticity and neuropathic painGordana Miletic; Fiscal Year: 2010..Second, from a therapeutic perspective, we seek to achieve better target specificity for more effective future therapeutic interventions. ..
- PROPAGATION OF INJURY DUE TO FOCAL CEREBRAL ISCHEMIAPhilip Weinstein; Fiscal Year: 1999..The induction of SD and ID by potassium chloride or ischemia will be correlated with induction of c-fos immediate early gene and D-MRI; regions in the ..
- REGULATE CA-2+ FOLLOWING ACTIVATION OF NMDA RECEPTORAMY MACDERMOTT; Fiscal Year: 1991..The experiments in this proposal will provide new, direct information on a previously incompletely described component of the response to glutamate; elevation of intracellular calcium...
- CALCIUM-DEPENDENT SURVIVAL OF DEVELOPING NEURONSZixu Mao; Fiscal Year: 2004..Membrane depolarizing concentrations of extracellular potassium chloride mimics neuronal activity in vivo to promote survival of neonatal cerebellar granule neurons...
- Mechanisms for inhibition of neurotransmitter release by the G protein GalphaoAndrew Bellemer; Fiscal Year: 2009..A better understanding of the mechanisms by which G proteins signal may provide a better understanding of how these processes are regulated. ..
- LKS AND LKUR IN GRANULOSA CELLSLisa Freeman; Fiscal Year: 2003..GC IKs and IKur may represent either novel targets for assisted reproduction, or potential sites of toxicity for drugs designed to treat arrhythmias, asthma, incontinence, immunosuppression or epilepsy. ..
- EFFECTS OF NUTRIENTS IN HYPERTENSIONROSE ROBERTSON; Fiscal Year: 1993..Repeated determination of baseline measures are performed at four and eight weeks to define both the extent and time course of these effects and to provide insight into their potential mechanisms...
- REGULATION OF DETRUSOR SMOOTH MUSCLE CONTRACTIONPAUL RATZ; Fiscal Year: 2005..Collectively, these studies will provide new insights into the cellular mechanisms regulating DSM contractions. ..
- Regulation of vascular smooth muscle calcium sensitivityPaul H Ratz; Fiscal Year: 2010..The Specific Aim of this study will be to test the hypothesis that ROK and PKCzeta both mediate KCI- induced Ca sensitization of FA, and that iPLA2 and PI3K are required as upstream activators of ROK and PKCzeta. ..
- Sexual dimorphism in seizure control is KCC2 mediatedARISTEA GALANOPOULOU; Fiscal Year: 2007..Albert Einstein College of Medicine will offer the necessary mentoring, laboratory space, equipment and training opportunities to achieve these goals. ..
- Calcium signaling in airway smooth muscle in lung slicesMichael Sanderson; Fiscal Year: 2007..abstract_text> ..
- CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLEMichael Sanderson; Fiscal Year: 2002..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
- The regulation of airway ciliary activityMichael Sanderson; Fiscal Year: 2005..abstract_text> ..
- Targeting Tumor Angiogenesis with G-Quadruplex BindersDaekyu Sun; Fiscal Year: 2010..abstract_text> ..
- DNA LIGASE I AS A POTENTIAL TARGET FOR ANTICANCER DRUGSDaekyu Sun; Fiscal Year: 2002..3) Test whether DNA ligase I inhibition produces antitumor activity using antisense strategy in preclinical in vitro and in vivo evaluation systems. 4) Develop a sensitive and reproducible assay for DNA ligase I. ..
- TRAINING IN SMOOTH AND CARDIAC MUSCLE BIOLOGYRichard Paul; Fiscal Year: 2003..This arrangement promotes scientific interactions and enhance the breadth of educational and research experiences in our cardiovascular training program. ..
- Septate junctional proteins: Proteomic identification and role in diuresisKLAUS BEYENBACH; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- NA-PUMP ISOFORM-SPECIFIC REGULATION OF VASCULAR FUNCTIONRichard Paul; Fiscal Year: 2004..The applicant will test the hypotheses that these isoforms are independently regulated and that the observed glucose-sensitivity of activation of vascular smooth muscle is a consequence of NKA alpha-isoform distribution. ..
- A cell-free system for exocytosis in the beta-cellSUSANNE STRAUB SHARP; Fiscal Year: 2005..physiological mechanisms such as time-dependent potentiation and biphasic insulin release. The method will also allow the study of some aspects of endocytosis. ..
- Kinetic Intermediates in Folding of Histone DimersLisa M Gloss; Fiscal Year: 2010..When these processes go awry because of misregulation of nucleosome function, assembly and dynamics, disease states result, particularly cancer. ..
- REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSIONCRAIG GELBAND; Fiscal Year: 2001....
- Endothelial Function in the Cerebral CirculationFrank Faraci; Fiscal Year: 2009..These studies should provide new insight into mechanisms of cerebral vascular protection during hypertension. ..
- Mathematical Model of Vascular and Tubular Transport in the Rat Outer MedullaAURELIE EDWARDS; Fiscal Year: 2008..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
- PHYSICOCHEMICAL INVESTIGATION OF TASTEVijay Lyall; Fiscal Year: 2010..The research will reveal how the sour taste defense mechanism functions to prevent the ingestion of acids. ..
- Chronic hypoxia and pulmonary vascular smooth muscleLarissa A Shimoda; Fiscal Year: 2010..Understanding the cellular changes that occur in the pulmonary vasculature with development of pulmonary hypertension is key to advancing treatment and therapeutic options. ..
- MOLECULAR PHARMACOLOGY OF VOLTAGE SENSITIVE NA CHANNELSEdward Moczydlowski; Fiscal Year: 2001..These biophysical studies will allow us deduce the functional contribution of key residues that determine ionic selectivity and unitary conductance of the NaV channel pore. ..
- MOLECULAR MECHANISMS OF RENAL FIBROSISERIC NEILSON; Fiscal Year: 2007..This understanding may be key to learning how we can further manipulate their participation in renal fibrosis. ..
- Chemokine Receptor Chimeras by Synthetic Gene LibraryMichael Dustin; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Serum Proteins Influencing Helicobacter pylori GrowthTRACI TESTERMAN; Fiscal Year: 2007..A more complete understanding of serum proteins interacting with bacteria could lead to advancements in cultivation of other organisms as well. ..
- MECHANISMS FOR ALTERED DETRUSOR CONTRACTILITY IN DIABETSamuel Chacko; Fiscal Year: 2002..An understanding of the molecular events that lead to contractile dysfunctions in diabetes is crucial in order to target the molecular steps for the development for pharmacological gents to treat diabetic cystopathy. ..
- MECHANISM OF KINESIN ATPASEDavid Hackney; Fiscal Year: 2002..These enzymatic studies will be coupled with study of the motility that kinesin is able to produce. A long range goal is to be able to model the physical properties of kinesin based on its solution biochemical mechanism, ..
- PREVENTION OF DENTAL CARIESShozo Takagi; Fiscal Year: 2005....
- NFAT and MEF-2 Choreograph Bladder Wall Remodeling Following Partial Outlet ObstrSTEPHEN ANTHONY ZDERIC; Fiscal Year: 2010..New therapy to preserve and enhance native bladder function will help avoid the development of the end stage bladder. ..
- MYOCARDIAL CALCIUM HANDLING DURING AND AFTER HYPOTHERMIADAVID STOWE; Fiscal Year: 2002..These studies will lead to a better understanding of Ca2+ loading and therapies to protect hypothermic hearts. ..
- EXOCYTOSIS & MEMBRANE TRAFFICKING IN NEUROENDOCRINE CELLJoseph Angleson; Fiscal Year: 2003..abstract_text> ..
- DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RATDONNA KORZICK; Fiscal Year: 2003..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
- Regulation of Kv2.1 TraffickingKRISTEN O CONNELL; Fiscal Year: 2005..Therefore understanding of this process will contribute to our knowledge of how membrane excitability is regulated. ..
- NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLEChristopher Rembold; Fiscal Year: 2004....
- Calcium, Dairy, and Body Fat in AdolescentsConnie Weaver; Fiscal Year: 2006..This study will evaluate calcium/dairy as a modulator of energy balance, important to the management of body fat in children. ..
- Regulation of Pancreas Development by P13K/Akt SignalingErnesto Bernal Mizrachi; Fiscal Year: 2006..abstract_text> ..
- CALCIUM METABOLISM IN ASIAN GIRLS AND POSTMENOPAUSAL WOMENConnie Weaver; Fiscal Year: 2006..Optimizing calcium retention during periods of rapid growth is a key nutritional strategy to build peak bone mass and reduce lifelong risk of osteoporosis. ..
- NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinomaWeibiao Cao; Fiscal Year: 2007..unreadable] [unreadable]..
- Polymer Carrier for Ischemia-Inducible Gene TherapyDavid Bull; Fiscal Year: 2007..abstract_text> ..
- PRESYNAPTIC MECHANISMS IN THE INTESTINEJames Galligan; Fiscal Year: 2008..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
- Enhanced cardiac sympathetic afferent reflex in CHFWei Wang; Fiscal Year: 2004....
- ImmunoreceptorsMichael Dustin; Fiscal Year: 2008..unreadable] [unreadable] [unreadable] [unreadable]..
- MYOSIN ISOFORM FUNCTION IN VASCULAR SMOOTH MUSCLEAnne Martin; Fiscal Year: 2003..These experiments will provide crucial information on the role of myosin isoforms in cardiovascular function in both physiological and pathological circumstances. ..
- Prostaglandins: Kinins and Angiotensin InteractionsJOHN MC GIFF; Fiscal Year: 2009..3) Heme oxygenase activity and suppression of EET and 20-HETE synthesis. 4) Activation of peroxisome-proliferator-activated receptor alpha by Fibrates with stimulation of EET synthesis. ..