potassium chloride

Summary

Summary: Potassium chloride. A white crystal or crystalline powder used as an electrolyte replenisher, in the treatment of hypokalemia, in buffer solutions, and in fertilizers and explosives.

Top Publications

  1. ncbi DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    Keri Martinowich
    Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Science 302:890-3. 2003
  2. ncbi Salt dependence of ion transport and DNA translocation through solid-state nanopores
    Ralph M M Smeets
    Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
    Nano Lett 6:89-95. 2006
  3. ncbi Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord
    C Morgado
    Faculty of Medicine of Porto and IBMC, Institute of Histology and Embryology, University of Porto, Alameda Prof Hernani Monteiro, Porto, Portugal
    Diabetes Obes Metab 13:150-9. 2011
  4. ncbi Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO
    Vikas Kapil
    William Harvey Research Institute, Barts and London Medical School, Queen Mary University of London, London, UK
    Hypertension 56:274-81. 2010
  5. pmc The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:535-53. 2005
  6. ncbi Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus
    Paul H Ratz
    Virginia Commonwealth Univ, School of Medicine, Dept of Biochemistry, 1101 E Marshall St, PO Box 980614, Richmond, VA 23298 0614, USA
    Am J Physiol Cell Physiol 288:C769-83. 2005
  7. ncbi Use of potassium chloride and flavor enhancers in low sodium Cheddar cheese
    J Grummer
    Department of Food Science and Nutrition, University of Minnesota, St Paul MN 55108, USA
    J Dairy Sci 96:1401-18. 2013
  8. ncbi Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction
    Sotaro Sakurada
    Department of Physiology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    Circ Res 93:548-56. 2003
  9. ncbi Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R
    Osamu Akizuki
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Shizuoka 411 8731, Japan
    Eur J Pharmacol 584:424-34. 2008
  10. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003

Detail Information

Publications232 found, 100 shown here

  1. ncbi DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation
    Keri Martinowich
    Neuroscience Interdepartmental Program, UCLA School of Medicine, 760 Westwood Plaza, Los Angeles, CA 90095, USA
    Science 302:890-3. 2003
    ..Our findings suggest that DNA methylation-related chromatin remodeling is important for activity-dependent gene regulation that may be critical for neural plasticity...
  2. ncbi Salt dependence of ion transport and DNA translocation through solid-state nanopores
    Ralph M M Smeets
    Kavli Institute of Nanoscience, Delft University of Technology, The Netherlands
    Nano Lett 6:89-95. 2006
    ..We demonstrate that the two competing effects cancel at a KCl concentration of 370 +/- 40 mM...
  3. ncbi Minocycline completely reverses mechanical hyperalgesia in diabetic rats through microglia-induced changes in the expression of the potassium chloride co-transporter 2 (KCC2) at the spinal cord
    C Morgado
    Faculty of Medicine of Porto and IBMC, Institute of Histology and Embryology, University of Porto, Alameda Prof Hernani Monteiro, Porto, Portugal
    Diabetes Obes Metab 13:150-9. 2011
    ..during mechanical hyperalgesia induced by diabetes may result from a decrease in the local expression of the potassium chloride co-transporter 2 (KCC2), which shifts the action of the neurotransmitter γ-amminobutiric acid (GABA) from ..
  4. ncbi Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO
    Vikas Kapil
    William Harvey Research Institute, Barts and London Medical School, Queen Mary University of London, London, UK
    Hypertension 56:274-81. 2010
    ....
  5. pmc The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:535-53. 2005
    ....
  6. ncbi Regulation of smooth muscle calcium sensitivity: KCl as a calcium-sensitizing stimulus
    Paul H Ratz
    Virginia Commonwealth Univ, School of Medicine, Dept of Biochemistry, 1101 E Marshall St, PO Box 980614, Richmond, VA 23298 0614, USA
    Am J Physiol Cell Physiol 288:C769-83. 2005
    ..KCl as a "simple" stimulus promises to remain a standard tool for smooth muscle cell physiologists, whose focus is to understand mechanisms regulating Ca2+ sensitivity...
  7. ncbi Use of potassium chloride and flavor enhancers in low sodium Cheddar cheese
    J Grummer
    Department of Food Science and Nutrition, University of Minnesota, St Paul MN 55108, USA
    J Dairy Sci 96:1401-18. 2013
    We investigated use of potassium chloride (KCl) to maintain both the salty flavor and to replace the preservative effects of salt when reducing the sodium content in natural cheese...
  8. ncbi Ca2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction
    Sotaro Sakurada
    Department of Physiology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    Circ Res 93:548-56. 2003
    ..Taken together, these results indicate the existence of the thus-far unrecognized Ca2+-dependent Rho stimulation mechanism in VSM. Excitatory receptor agonists are suggested to use this pathway for simulating Rho...
  9. ncbi Blockade of T-type voltage-dependent Ca2+ channels by benidipine, a dihydropyridine calcium channel blocker, inhibits aldosterone production in human adrenocortical cell line NCI-H295R
    Osamu Akizuki
    Pharmaceutical Research Center, Kyowa Hakko Kogyo Co, Ltd, Shizuoka 411 8731, Japan
    Eur J Pharmacol 584:424-34. 2008
    ..T-type Ca2+ channels may contribute to additional benefits of this drug for treating renal and cardiovascular diseases, beyond its primary anti-hypertensive effects from blocking L-type Ca2+ channels...
  10. ncbi Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2
    Wen G Chen
    Division of Neuroscience, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Science 302:885-9. 2003
    ..These studies indicate that MeCP2 plays a key role in the control of neuronal activity-dependent gene regulation and suggest that the deregulation of this process may underlie the pathology of RT T...
  11. ncbi Transient synaptic activation of NMDA receptors leads to the insertion of native AMPA receptors at hippocampal neuronal plasma membranes
    L Pickard
    MRC Centre for Synaptic Plasticity, Department of Anatomy, University of Bristol, School of Medical Sciences, University Walk, BS8 1TD, Bristol, UK
    Neuropharmacology 41:700-13. 2001
    ..Our data indicate that the transient synaptic activation of NMDARs can lead to the insertion of native AMPARs at sites on the neuronal membrane that initially lacks AMPARs...
  12. pmc IL-13 enhances agonist-evoked calcium signals and contractile responses in airway smooth muscle
    Omar Tliba
    Department of Medicine, Pulmonary Allergy and Critical Care Division, University of Pennsylvania, BRB II III, 421 Curie Boulevard, Philadelphia, PA 19104, USA
    Br J Pharmacol 140:1159-62. 2003
    ..The present study demonstrates that IL-13 may promote BHR by directly modulating ASM contractility, an effect that may be due to enhanced G protein-coupled receptor (GPCR)-associated calcium signaling...
  13. ncbi Alpha7-nicotinic acetylcholine receptors on cerebral perivascular sympathetic nerves mediate choline-induced nitrergic neurogenic vasodilation
    Min Liang Si
    Department of Pharmacology, Southern Illinois University School of Medicine, Springfield, Ill 62794 9629, USA
    Circ Res 91:62-9. 2002
    ..Endogenous choline may play an important role in regulating cerebral sympathetic activity and vascular tone...
  14. ncbi A biochemical and molecular characterization of LEP1, an extensin peroxidase from lupin
    Nicholas J Price
    Instituto de Tecnologia Quimica e Biologica, Apartado 127, 2781 901 Oeiras, Portugal
    J Biol Chem 278:41389-99. 2003
    ..Comparative modeling of the translated sequence indicated an unusually unobstructed equatorial cleft across the substrate access channel, which might facilitate interaction with extensin and confer higher EP activity...
  15. ncbi Depolarization induces acetylation of histone H2B in the hippocampus
    C Maharana
    National Brain Research Centre, Manesar, Haryana 122050, India
    Neuroscience 167:354-60. 2010
    ..These results show that acetylation of histone H2B is regulated in an activity-dependent manner by the molecular events important for synaptic plasticity and memory...
  16. ncbi Age-related changes in cholinergic and purinergic neurotransmission in human isolated bladder smooth muscles
    M Yoshida
    Department of Urology, Kumamoto University School of Medicine, 1 1 1 Honjo, 860 8556, Kumamoto, Japan
    Exp Gerontol 36:99-109. 2001
    ..The age-related changes in neurotransmissions may contribute to the changes in bladder function in the elderly...
  17. ncbi Recruitment of smooth muscle cells and arterial vasomotion
    Mathieu Lamboley
    Cellular Biophysics and Biomechanics Laboratory, Swiss Federal Institute of Technology, SG AA B 1 44, CH 1015 Lausanne, Switzerland
    Am J Physiol Heart Circ Physiol 285:H562-9. 2003
    ..We conclude that the number of simultaneously recruited cells is an important factor in controlling rat mesenteric artery contraction and vasomotion...
  18. ncbi Effects of potassium chloride and potassium bicarbonate on endothelial function, cardiovascular risk factors, and bone turnover in mild hypertensives
    Feng J He
    Wolfson Institute of Preventive Medicine, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK
    Hypertension 55:681-8. 2010
    ..supplementation on endothelial function, cardiovascular risk factors, and bone turnover and to compare potassium chloride with potassium bicarbonate, we carried out a 12-week randomized, double-blind, placebo-controlled crossover ..
  19. ncbi Manufacture of low-sodium Minas fresh cheese: effect of the partial replacement of sodium chloride with potassium chloride
    A P Gomes
    Universidade de Taubate, Curso de Engenharia de Alimentos, Estrada Municipal Dr José Luis Cembranelli, 5000, Fazenda Piloto, Itaim, Taubate, Sao Paulo, Brasil CEP12081 010
    J Dairy Sci 94:2701-6. 2011
    We investigated the effect of sodium reduction by partial substitution of sodium chloride (NaCl) with potassium chloride (KCl) on the manufacture of Minas fresh cheese during 21 d of refrigerated storage...
  20. ncbi Rho-kinase inhibition suppresses potassium chloride-induced bladder hyperactivity in a rat model
    Mahadevan Rajasekaran
    Division of Urology, University of California, San Diego, Medical Center, San Diego, California 92103 8897, USA
    Urology 69:791-4. 2007
    ..In the present study, we tested our hypothesis that potassium chloride (KCl)-induced bladder hyperactivity might be mediated through a calcium-sensitizing RhoA-Rho-kinase pathway ..
  21. ncbi KCl evokes contraction of airway smooth muscle via activation of RhoA and Rho-kinase
    Luke J Janssen
    Asthma Research Group, Firestone Institute for Respiratory Health, Saint Joseph s Hospital, Hamilton, Ontario, L8N 4A6, Canada
    Am J Physiol Lung Cell Mol Physiol 287:L852-8. 2004
    ..KCl-induced elevation of [Ca2+]i was not affected by Y-27632 but was reversed by NiCl2 or by BAPTA-AM. We conclude that KCl acts in part through stimulation of Rho and ROCK, possibly secondary to voltage-dependent Ca2+ influx...
  22. ncbi Management of a case of uterine scar pregnancy by transabdominal potassium chloride injection
    J Hartung
    Ultrasound Obstet Gynecol 21:94-5. 2003
  23. ncbi Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo
    Y Matsuka
    Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA 90095-1668, USA
    Brain Res 915:248-55. 2001
    ..Robust ATP release was evoked with 5 microM capsaicin. These data suggest that ATP is released concurrently with SP from the somata of neurons within sensory ganglia...
  24. pmc p38 mitogen-activated protein kinase and calcium channels mediate signaling in depolarization-induced activation of peroxisome proliferator-activated receptor gamma coactivator-1alpha in neurons
    Huan Ling Liang
    Department of Cell Biology, Neurobiology and Anatomy, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Neurosci Res 88:640-9. 2010
    ..Our results indicate that both p38 MAPK and calcium play important roles in mediating signaling in depolarization-induced activation of PGC-1alpha at the protein and message levels in neurons...
  25. ncbi Fatal intravenous injection of potassium in hospitalized patients
    Angela R Wetherton
    Department of Pathology and Laboratory Medicine, University of Louisville School of Medicine, Kentucy, USA
    Am J Forensic Med Pathol 24:128-31. 2003
    ..These cases illustrate the subtlety of findings in such deaths and remind the forensic pathologist to consider this type of event in sudden, unexpected death of hospitalized patients...
  26. pmc Suppression of endogenous PPARγ increases vulnerability to methamphetamine-induced injury in mouse nigrostriatal dopaminergic pathway
    Seong Jin Yu
    National Institute on Drug Abuse, IRP, Neural Protection and Regeneration Section, 251 Bayview Boulevard, 06 721A, Baltimore, MD 21224, USA
    Psychopharmacology (Berl) 221:479-92. 2012
    ..Previous studies have shown that pretreatment with peroxisome proliferator-activated receptor gamma (PPARγ) agonist reduced methamphetamine-induced neurodegeneration...
  27. ncbi Capsaicin-induced, capsazepine-insensitive relaxation of the guinea-pig ileum
    Seigo Fujimoto
    Department of Cellular and Molecular Pharmacology, Nagoya City University Graduate School of Medical Sciences, Kawasumi, Mizuho cho, Mizuho ku, Japan
    Eur J Pharmacol 530:144-51. 2006
    ..The relaxation could be explained by a decrease in phosphorylation of MLC(20)...
  28. ncbi Medication errors: inadvertent administration of potassium chloride
    S L Emmett
    Victorian Institute of Forensic Medicine and Department of Forensic Medicine, Monash University
    J Law Med 11:146-7. 2003
  29. ncbi Potassium chloride supplementation alone may not improve hypokalemia in thyrotoxic hypokalemic periodic paralysis
    Tsuan Shih Yu
    Division of Nephrology, Department of Medicine, Cardinal Tien Hospital, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan
    J Emerg Med 32:263-5. 2007
    ..He was found to have severe hypokalemia, with K(+) level at 1.7 mmol/L. However, after administration of potassium chloride (KCl), 10 mEq/h intravenous (i.v.) drip for 4 h, follow-up serum potassium was even lower at 1...
  30. ncbi Application of potassium chloride to a Chernobyl-contaminated lake: modelling the dynamics of radiocaesium in an aquatic ecosystem and decontamination of fish
    James T Smith
    Centre for Ecology and Hydrology, Winfrith Technology Centre, Dorchester, DT2 8ZD, Dorset, UK
    Sci Total Environ 305:217-27. 2003
    ..In February 1998 we applied 15 t of potassium chloride to Lake Svyatoe, Kostiukovichy...
  31. ncbi The effect of cardioplegic solution-induced sodium concentration fluctuation on postoperative seizure in pediatric cardiac patients
    Jin Tae Kim
    Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea
    Ann Thorac Surg 91:1943-8. 2011
    ..We evaluated the relationship between the cardioplegic solution, the fluctuation of sodium concentration, and the incidence of postoperative seizure in pediatric cardiac patients...
  32. ncbi Intravenous potassium chloride prescribing and administration practices in Victoria: an observational study
    Melita A Van de Vreede
    Pharmacy Department, Bayside Health, Melbourne, Vic, Australia
    Med J Aust 189:575-7. 2008
    To identify current prescribing and administration practices in relation to intravenous potassium chloride (IV KCl).
  33. ncbi KCl potentiates forskolin-induced PC12 cell neurite outgrowth via protein kinase A and extracellular signal-regulated kinase signaling pathways
    Thomas V O Hansen
    Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, DK 2100, Copenhagen, Denmark
    Neurosci Lett 347:57-61. 2003
    ..The results demonstrate that PKA and ERK play a key role in KCl- and forskolin-induced neuronal differentiation by integration of signals from both pathways...
  34. ncbi The role of potassium chloride cotransporters in murine and human sperm volume regulation
    T Klein
    Institute of Reproductive Medicine, University of Munster, D 48129 Munster, Germany
    Biol Reprod 75:853-8. 2006
    ..Therefore, besides organic osmolyte efflux and KCl release through separate K(+) and Cl(-) ion channels, SLC12A7 also is involved in murine but not human sperm RVD mechanisms...
  35. ncbi Intravesical protamine sulfate and potassium chloride as a model for bladder hyperactivity
    Yao Chi Chuang
    Division of Urology, Chang Gung Memorial Hospital, Kaohsiung, Taiwan
    Urology 61:664-70. 2003
    ..animal model for hyperactive bladder in rats was developed using intravesical infusion of protamine sulfate (PS), an agent thought to break down urothelial barrier function, and physiologic concentrations of potassium chloride (KCl).
  36. pmc Improving outcome of treatment of kala-azar by supplementation of amphotericin B with physiologic saline and potassium chloride
    Chandeshwar P Thakur
    Balaji Utthan Sansthan, Patna, India
    Am J Trop Med Hyg 83:1040-3. 2010
    ....
  37. ncbi Upregulation by KCl treatment of eukaryotic translation elongation factor 1A (eEF1A) mRNA in the dendrites of cultured rat hippocampal neurons
    Il Soo Moon
    Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 780 714, Korea
    Mol Cells 25:538-44. 2008
    ..These results indicate that KCl treatment increases both the density of eEF1A mRNA clusters and their synaptic association in dendrites of cultured neurons...
  38. pmc Neuronal activation increases the density of eukaryotic translation initiation factor 4E mRNA clusters in dendrites of cultured hippocampal neurons
    Il Soo Moon
    Department of Anatomy, College of Medicine, Dongguk University, Gyeongju 780 714, Korea
    Exp Mol Med 41:601-10. 2009
    ..This provides a potential mechanism by which protein translation at synapses may be enhanced in response to synaptic stimulation...
  39. pmc Studies on the structure and dynamics of the human telomeric G quadruplex by single-molecule fluorescence resonance energy transfer
    Liming Ying
    Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge CB2 1EW, United Kingdom
    Proc Natl Acad Sci U S A 100:14629-34. 2003
    ..The unfolding free energy barrier is estimated to be between 3 and 15 kBT based on Kramers' theory. We conclude that under near-physiological conditions these structures coexist and can interconvert on a minute time scale...
  40. ncbi On the value of c: can low affinity systems be studied by isothermal titration calorimetry?
    W Bruce Turnbull
    Astbury Centre for Structural Molecular Biology, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT, UK
    J Am Chem Soc 125:14859-66. 2003
    ..Therefore, isothermal titration calorimetry is a valid and useful technique for studying biologically and synthetically important low affinity systems...
  41. ncbi The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
    S Yasuda
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Mol Psychiatry 14:51-9. 2009
    ..Our results have strong implications for the therapeutic actions of these two mood stabilizers...
  42. ncbi Activity-induced targeting of profilin and stabilization of dendritic spine morphology
    Manuel Ackermann
    Friedrich Miescher Institute, Box 2543, 4002 Basel, Switzerland
    Nat Neurosci 6:1194-200. 2003
    ..These results suggest that, in addition to electrophysiological changes, NMDA receptor activation initiates changes in the actin cytoskeleton of dendritic spines that stabilize synaptic structure...
  43. ncbi The actin-binding protein profilin I is localized at synaptic sites in an activity-regulated manner
    Henrike Neuhoff
    Zentrum fur Molekulare Neurobiologie Hamburg, ZMNH, University of Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    Eur J Neurosci 21:15-25. 2005
    ..These results show that profilin I can be present at both pre- and postsynaptic sites and suggest a role for this actin-binding protein in activity-dependent remodelling of synaptic structure...
  44. ncbi Tumor necrosis factor-alpha triggers cell death of sensitized potassium chloride-stimulated cholinergic neurons
    Birgit Zassler
    Laboratory of Psychiatry, Department of Psychiatry, University Hospital Innsbruck, Anichstr 35, Austria
    Brain Res Mol Brain Res 113:78-85. 2003
    ..When co-slices of basal nucleus of Meynert and neocortex were sensitized for 15 min with 30 mM potassium chloride and subsequently incubated for 1 week with 20 ng/ml TNF-alpha, cholinergic neurons and nerve fibers markedly ..
  45. pmc Role of Rho-kinase in mediating contraction of chicken embryo femoral arteries
    Bea Zoer
    Department of Pediatrics, Maastricht University Medical Centre, School for Oncology and Developmental Biology GROW, P Debyelaan 25, P O Box 5800, 6202 AZ Maastricht, The Netherlands
    J Comp Physiol B 180:427-35. 2010
    ..In summary, our findings are indicative of a role for Rho-kinase activity in depolarization- and agonist-induced force generation in chicken embryo femoral arteries...
  46. ncbi Chronic antidepressants reduce depolarization-evoked glutamate release and protein interactions favoring formation of SNARE complex in hippocampus
    Giambattista Bonanno
    Section of Pharmacology and Toxicology, Department of Experimental Medicine, and Center of Excellence for Biomedical Research, University of Genoa, 16148 Genoa, Italy
    J Neurosci 25:3270-9. 2005
    ....
  47. ncbi Sustained-release potassium chloride overdose
    M Su
    New York City Poison Control Center, NYU Bellevue Hospital Center, Department of Emergency Medicine, New York 10016, USA
    J Toxicol Clin Toxicol 39:641-8. 2001
    ..We report 2 cases of hyperkalemia in patients with normal renal function who developed hyperkalemia after ingesting sustained-release potassium preparations and describe the use of radiography and whole-bowel irrigation in their care...
  48. ncbi Activity-dependent transcription regulation of PSD-95 by neuregulin-1 and Eos
    Jianxin Bao
    Department of Otolaryngology, Washington University, St Louis, Missouri 63110, USA
    Nat Neurosci 7:1250-8. 2004
    ..This upregulation of PSD-95 expression by the Nrg-ICD-Eos complex provides a molecular basis for activity-dependent synaptic plasticity...
  49. ncbi The effects of inhibiting Rho-associated kinase with Y-27632 on force and intracellular calcium in human myometrium
    S Kupittayanant
    Department of Physiology, University of Liverpool, Crown Street, Liverpool L69 3BX, UK
    Pflugers Arch 443:112-4. 2001
    ..This suggests that the Rho-A-ROK pathway may not be a potent modulator of force in the human myometrium under physiological conditions...
  50. ncbi Enhanced force generation by corpus cavernosum smooth muscle in rabbits with partial bladder outlet obstruction
    Shaohua Chang
    Division of Urology, Department of Pathobiology, University of Pennsylvania, Philadelphia, PA, USA
    J Urol 167:2636-44. 2002
    ..We determined whether corpus cavernosum smooth muscle from rabbits with partial bladder outlet obstruction show any molecular or functional differences versus controls...
  51. ncbi Clinical review: Thyrotoxic periodic paralysis: a diagnostic challenge
    Annie W C Kung
    Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, China
    J Clin Endocrinol Metab 91:2490-5. 2006
    ..The aim of this article was to review the clinical presentation, pathogenesis, and management of thyrotoxic periodic paralysis (TPP)...
  52. ncbi The effects of salt on the TATA binding protein-DNA interaction from a hyperthermophilic archaeon
    R O'BRIEN
    Department of Biochemistry and Molecular Biology, University College London, UK
    J Mol Biol 279:117-25. 1998
    ..Isothermal titration calorimetric binding studies were performed under a range of salts (potassium chloride, potassium phosphate, potassium acetate and sodium acetate) at varying concentrations (0.8 to 1.6 M)...
  53. ncbi Enthalpy and heat capacity changes for the proton dissociation of various buffer components in 0.1 M potassium chloride
    H Fukada
    Laboratory of Biophysical Chemistry, College of Agriculture, Osaka Prefecture University, Sakai, Japan
    Proteins 33:159-66. 1998
    ..1 M potassium chloride at temperatures ranging from 5 to 45 degrees C...
  54. ncbi Depolarization activates ERK and proline-rich tyrosine kinase 2 (PYK2) independently in different cellular compartments in hippocampal slices
    Jean Christophe Corvol
    Signal Transduction and Plasticity in the Nervous System Unit, INSERM Université Pierre et Marie Curie U536, Institut du Fer a Moulin, 75005 Paris, France
    J Biol Chem 280:660-8. 2005
    ....
  55. pmc The formation pathway of tetramolecular G-quadruplexes
    Caroline Bardin
    Laboratoire de Chimie et Biologie Structurale, Institut de Chimie des Substances Naturelles, Gif sur Yvette, 91190, France
    Nucleic Acids Res 36:477-88. 2008
    ....
  56. ncbi The effect of salts on the activity and stability of Escherichia coli and Haloferax volcanii dihydrofolate reductases
    Donna B Wright
    School of Molecular Biosciences, Washington State University, Pullman, WA 99164 4460, USA
    J Mol Biol 323:327-44. 2002
    ..In support of this conclusion, all three DHFRs are similarly stabilized by the non-ionic cosolute, sucrose...
  57. ncbi Swelling behavior of the tomato cell wall network
    A J MacDougall
    Food Biopolymer Section, Institute of Food Research, Norwich Laboratory, Norwich Research Park, Colney, Norwich NR4 7UA, U K
    Biomacromolecules 2:450-5. 2001
    ..Conditions were chosen to include those that would be encountered in vivo. Swelling in these systems was strongly influenced by the polyelectrolyte nature of the polymer and the extent of cross-linking with divalent counterions...
  58. ncbi Neuronally released acetylcholine acts on the M2 muscarinic receptor to oppose the relaxant effect of isoproterenol on cholinergic contractions in mouse urinary bladder
    Frederick J Ehlert
    Department of Pharmacology, University of California, Irvine, CA 92697 4625, USA
    J Pharmacol Exp Ther 322:631-7. 2007
    ....
  59. ncbi In vitro and in vivo evaluation of potassium chloride sustained release formulation prepared with saturated polyglycolyed glycerides matrices
    Pao Chu Wu
    College of Pharmacy, Kaohsiung Medical University, No 100 Shih Chen 1st R D, Kaohsiung 807, Taiwan, ROC
    Int J Pharm 243:119-24. 2002
    The aim of the present work was to evaluate the effect of sustained release of potassium chloride semi-solid matrices prepared with different kinds and added amounts of Gelucires by the in vitro dissolution test and in vivo oral ..
  60. ncbi 2-Aminoethoxydiphenyl borate inhibits KCl-induced vascular smooth muscle contraction
    Paul H Ratz
    Department of Biochemistry, Virginia Commonwealth University, School of Medicine, Richmond, 23298 0614, USA
    Eur J Pharmacol 541:177-83. 2006
    ..These data support the conclusion that membrane depolarization activates 2-APB-sensitive TRPs in addition to VOCs to permit strong force-maintenance in tonic vascular smooth muscle...
  61. ncbi Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors
    Pia Agren
    Department of Pediatrics, Maastricht University Hospital, Research Institute Growth and Development GROW, University of Maastricht, Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 292:R485-96. 2007
    ....
  62. ncbi Effects of sex and estrogen on chicken ductus arteriosus reactivity
    Thijs W H Flinsenberg
    Department of Pediatrics, Maastricht University Medical Center, GROW School for Oncology and Developmental Biology, P Debyelaan 25, Maastricht, The Netherlands
    Am J Physiol Regul Integr Comp Physiol 298:R1217-24. 2010
    ..The estrogen 17beta-estradiol induces an endothelium-independent relaxation of chicken DA that is not mediated by ER activation. This relaxant effect is, at least partially, due to inhibition of Ca(2+) entry from extracellular space...
  63. ncbi Reconstitution and functional characterization of the unusual bi-subunit type I DNA topoisomerase from Leishmania donovani
    Benu Brata Das
    Department of Molecular Parasitology, Indian Institute of Chemical Biology 4, Raja S C Mullick Road, Kolkata 700032, India
    FEBS Lett 565:81-8. 2004
    ..Interaction between the two subunits leading to the formation of an active complex could be explored as an insight for development of new therapeutic agents with specific selectivity...
  64. ncbi Acid-base effects of a bicarbonate-balanced priming fluid during cardiopulmonary bypass: comparison with Plasma-Lyte 148. A randomised single-blinded study
    T J Morgan
    Department of Anaesthesia, Princess Alexandra Hospital, Brisbane, Queensland, Australia
    Anaesth Intensive Care 36:822-9. 2008
    ..These are likely to be gluconate and/or acetate. Whether surges of exogenous anions during bypass can be harmful requires further study...
  65. ncbi The large subunit of Leishmania topoisomerase I functions as the 'molecular steer' in type IB topoisomerase
    Somdeb BoseDasgupta
    Department of Molecular Parasitology, Indian Institute of Chemical Biology, Kolkata 700032, India
    Mol Microbiol 67:31-46. 2008
    ..Therefore this study helps in a better understanding of the mechanistic details underlying topoisomerization by this bi-subunit enzyme...
  66. ncbi Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase
    Wu Bing
    Department of Pathobiology, University of Pennsylvania, Philadelphia 19104, USA
    Am J Physiol Renal Physiol 285:F990-7. 2003
    ..These results suggest that the ROK-mediated pathway is partly responsible for the high degree of force maintenance and slow relaxation in the detrusor from DB...
  67. ncbi Quaternary ammonium salt derivative of haloperidol inhibits KCl-induced calcium increase in rat aortic smooth muscle cells
    G G Shi
    Department of Pharmacology, Shantou University Medical College, Shantou 515031, China
    Acta Pharmacol Sin 22:837-40. 2001
    ..To study the effect of quaternary ammonium salt derivative of haloperidol (F3) on intracellular calcium (Ca2+) dynamic change in vascular smooth muscle cells (VSMC)...
  68. ncbi Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2
    Henry H C Lee
    Department of Neuroscience, School of Medicine, University of Pennsylvania, Pennsylvania 19104, USA
    J Biol Chem 282:29777-84. 2007
    The potassium chloride cotransporter KCC2 plays a major role in the maintenance of transmembrane chloride potential in mature neurons; thus KCC2 activity is critical for hyperpolarizing membrane currents generated upon the activation of ..
  69. pmc Stress-specific role of fission yeast Gcn5 histone acetyltransferase in programming a subset of stress response genes
    Anna Johnsson
    School of Life Sciences, Södertörns högskola, SE 141 89 Huddinge, Sweden
    Eukaryot Cell 5:1337-46. 2006
    ....
  70. pmc Enhanced excitation-coupled calcium entry in myotubes expressing malignant hyperthermia mutation R163C is attenuated by dantrolene
    Gennady Cherednichenko
    Department of Molecular Biosciences, School of Veterinary Medicine, One Shields Avenue, University of California, Davis, CA 95616, USA
    Mol Pharmacol 73:1203-12. 2008
    ..The inhibitory potency of dantrolene on ECCE found in wild-type and MH-susceptible muscle is consistent with the drug's clinical potency for reversing the MH syndrome and is incomplete as predicted by its efficacy as a muscle relaxant...
  71. pmc Intravitreous injection of a membrane depolarization agent causes retinal degeneration via matrix metalloproteinase-9
    Raghuveer S Mali
    Eye Research Institute of Oakland University, Rochester, MI 48309, USA
    Invest Ophthalmol Vis Sci 46:2125-32. 2005
    ..In this study, KCl, a classic membrane depolarizing agent, was injected into the vitreous humor, and the role of matrix metalloproteinase (MMP)-9 in KCl-induced retinal damage was investigated...
  72. ncbi Characterisation of CGRP receptors in human and porcine isolated coronary arteries: evidence for CGRP receptor heterogeneity
    Saurabh Gupta
    Department of Pharmacology, University Medical Center Rotterdam, The Netherlands
    Eur J Pharmacol 530:107-16. 2006
    ....
  73. ncbi Extracellular matrix proteins differentially regulate airway smooth muscle phenotype and function
    Bart G J Dekkers
    Department of Molecular Pharmacology, University Centre for Pharmacy, University of Groningen, A Deusinglaan 1, 9713 AV Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 292:L1405-13. 2007
    ..Our results indicate that ECM proteins differentially regulate both phenotype and function of intact ASM...
  74. ncbi Kinesin tail domains and Mg2+ directly inhibit release of ADP from head domains in the absence of microtubules
    David D Hackney
    Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
    Biochemistry 47:7770-8. 2008
    ..Tail domains only weakly inhibit the initial slow release of Mg (2+) from the kinesin-MgADP complex but strongly inhibit the fast release of Mg (2+)-free ADP...
  75. ncbi o-GlcNAc transferase is activated by CaMKIV-dependent phosphorylation under potassium chloride-induced depolarization in NG-108-15 cells
    Minseok Song
    Department of Life Science, Division of Molecular and Life Science, Pohang University of Science and Technology, Pohang, Kyung Buk 790 784, Republic of Korea
    Cell Signal 20:94-104. 2008
    ..Here, we report that potassium chloride-induced depolarization provokes the activation of OGT and subsequent o-GlcNAcylation of proteins in ..
  76. pmc The contraction of smooth muscle cells of intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KCl
    Jose F Perez
    Department of Physiology, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Gen Physiol 125:555-67. 2005
    ..We hypothesize that the magnitude of the sustained intrapulmonary SMC contraction is determined by the frequency of Ca(2+) oscillations and also by the relaxation rate of the SMC...
  77. ncbi Ability of thrombin to act as molecular chaperone, inducing formation of quadruplex structure of thrombin-binding aptamer
    Eva Baldrich
    Department of Chemical Engineering, Universitat Rovira Virgili, Avinguda Paisos Catalans 26, 43007 Tarragona, Spain
    Anal Biochem 341:194-7. 2005
  78. ncbi Robust axonal sprouting and synaptogenesis in organotypic slice cultures of rat cerebellum exposed to increased potassium chloride
    Suzanne Chen
    Department of Otolaryngology and Physiology and Neuroscience, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA
    Brain Res 1057:88-97. 2005
    ....
  79. ncbi Gender-related neuronal and smooth muscle damage of guinea pig isolated urinary bladder from anoxia-glucopenia and reperfusion injury and its relationship to glycogen content
    Federica Pessina
    Dipartimento di Scienze Biomediche, Universita di Siena, Siena, Italy
    Neurourol Urodyn 26:416-23. 2007
    ..To investigate the effects of anoxia and glucopenia (A-G) on both male and female guinea pig urinary bladder...
  80. ncbi Role of Rho-kinase in maintaining airway smooth muscle contractile phenotype
    Reinoud Gosens
    Department of Molecular Pharmacology, University Centre for Pharmacy, A Deusinglaan 1, 9713 AV, Groningen, The Netherlands
    Eur J Pharmacol 483:71-8. 2004
    ..Rho-kinase is, however, a major regulator involved in the basal maintenance of contractility in bovine tracheal smooth muscle...
  81. ncbi Does cyclic AMP mediate rat urinary bladder relaxation by isoproterenol?
    Elfaridah P Frazier
    Department of Pharmacology and Pharmacotherapy, University of Amsterdam, Academisch Medisch Centrum, The Netherlands
    J Pharmacol Exp Ther 313:260-7. 2005
    ..We conclude that cAMP and cGMP each play a minor role in beta-adrenergic receptor-mediated relaxation against passive tension, and calcium-dependent potassium channels play a minor role against active tension...
  82. ncbi Successful management of a heterotopic Caesarean scar pregnancy: potassium chloride injection with preservation of the intrauterine gestation: case report
    L J Salomon
    Service de Gynecologie Obstetrique, Hopital Antoine Beclere, Assistance Publique Hopitaux de Paris AP HP, 157 rue de la Porte de Trivaux, 92140 Clamart, France
    Hum Reprod 18:189-91. 2003
    ..We report the first case of CSP associated with a normal intrauterine pregnancy. Potassium chloride administered under transvaginal ultrasonographic guidance terminated cardiac activity in the CSP...
  83. ncbi Involvement of bidirectional adenosine transporters in the release of L-[3H]adenosine from rat brain synaptosomal preparations
    J G Gu
    Department of Pharmacology and Therapeutics, University of Manitoba, Faculty of Medicine, Winnipeg, Canada
    J Neurochem 64:2105-10. 1995
    ..abstract truncated at 250 words)..
  84. ncbi Maternal complication of cervical heterotopic pregnancy after successful potassium chloride fetal reduction
    Cynthia Gyamfi
    Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Mount Sinai School of Medicine, New York, New York 10029, USA
    Fertil Steril 82:940-3. 2004
    To present a case of maternal morbidity encountered in a cervical heterotopic pregnancy after successful potassium chloride (KCl) injection for transvaginal multifetal pregnancy reduction.
  85. ncbi Inadequate anaesthesia in lethal injection for execution
    Leonidas G Koniaris
    DeWitt Daughtry Family Department of Surgery, School of Business, University of Miami, Miami, FL, USA
    Lancet 365:1412-4. 2005
    ..Lethal injection is usually done by sequential administration of thiopental, pancuronium, and potassium chloride. Protocol information from Texas and Virginia showed that executioners had no anaesthesia training, drugs ..
  86. ncbi Contribution of Rho-kinase in human gallbladder contractions
    Kansu Buyukafsar
    Department of Pharmacology, Medical Faculty, Mersin University, Campus Yenişehir 33169 Mersin, Turkey
    Eur J Pharmacol 540:162-7. 2006
    ..10(-8) M), histamine (10(-5) M), neurokinin A (10(-7)-10(-6) M), 5-hydroxytryptamine (10(-6)-10(-5) M) and potassium chloride (KCl, 25-50 mM)-induced contractions as well as spontaneous contractile activity...
  87. ncbi Rad52 protein has a second stimulatory role in DNA strand exchange that complements replication protein-A function
    James H New
    Section of Microbiology, University of California, Davis, California 95616, USA
    J Biol Chem 277:26171-6. 2002
    ..We propose that Rad52 protein acts by stabilizing the Rad51 presynaptic filament...
  88. pmc Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter
    Adnan Levent
    Department of Pharmacology, Medical Faculty, Mersin University Campus, Yenişehir 33169, Mersin, Turkey
    Br J Pharmacol 143:431-7. 2004
    ..Since Y-27632 and fasudil depressed the contractions, it seems plausible to postulate that Rho-kinase inhibitors may be beneficial in the treatment of renal colic...
  89. ncbi Multiple mechanisms of transmitter release evoked by "pathologically" elevated extracellular [K+]: involvement of transporter reversal and mitochondrial calcium
    Luca Raiteri
    Department of Experimental Medicine, Pharmacology and Toxicology Section, University of Genova, Genova, Italy
    J Neurochem 80:706-14. 2002
    ..These include carrier-mediated release and internal Ca2+-dependent exocytosis; in the latter, mitochondrial Ca2+ seems to play a primary role...
  90. ncbi Matrix-degrading enzymes tissue plasminogen activator and matrix metalloprotease-3 in the hypothalamo-neurohypophysial system
    Seiji Miyata
    Department of Applied Biology, Kyoto Institute of Technology, Matsugasaki, Kyoto, Japan
    Brain Res 1058:1-9. 2005
    ....
  91. ncbi Calcium channels coupled to glutamate release identified by omega-Aga-IVA
    T J Turner
    Department of Physiology, Tufts University School of Medicine, Boston, MA 02111
    Science 258:310-3. 1992
    ..A presynaptic calcium channel important in glutamate release is shown to be omega-Aga-IVA sensitive and omega-conotoxin resistant...
  92. ncbi Risk of surgery after use of potassium chloride for treatment of tubal heterotopic pregnancy
    Jerald S Goldstein
    Department of Obstetrics and Gynecology, Washington University, St Louis, MO 63108, USA
    Obstet Gynecol 107:506-8. 2006
    ..physicians have attempted treatment of heterotopic pregnancies with minimally invasive procedures such as transvaginal guided potassium chloride (KCl) injection. However, there are few data on the success of this treatment.
  93. pmc Computer modeling reveals that modifications of the histone tail charges define salt-dependent interaction of the nucleosome core particles
    Ye Yang
    School of Biological Sciences, Nanyang Technological University, Singapore
    Biophys J 96:2082-94. 2009
    ..A more detailed description of the NCP did not change the main features of the results. Overall, the results of this work are in agreement with experimental data reported for NCP solutions and for chromatin arrays...
  94. ncbi Potent inhibition by tamoxifen of spontaneous and agonist-induced contractions of the human myometrium and intramyometrial arteries
    A Kostrzewska
    Institute of Obstetrics and Gynaecology, Medical Academy, Bialystok, Poland
    Am J Obstet Gynecol 176:381-6. 1997
    ..Our purpose was to elucidate the mechanism of direct (nongenomic) action of antiestrogens on spontaneous and agonist-induced contractions of the human myometrium and uterine arteries...
  95. ncbi Rapid release of Mg(2+) from liver mitochondria by nonesterified long-chain fatty acids in alkaline media
    Peter Schonfeld
    Institute of Biochemistry, Otto von Guericke University, Leipziger Strasse 44, D 39120 Magdeburg, Germany
    Arch Biochem Biophys 403:16-24. 2002
    ..It is hypothesized that fatty acids activate an intrinsic Mg(2+)/H(+) exchanger that is related to, or identical with, the K(+)/H(+) exchanger...
  96. ncbi Effects of idarubicin and idarubicinol on rat coronary resistance and vasoconstrictor responsiveness of isolated aorta and mesentery
    Michael Weiss
    Section of Pharmacokinetics, Martin Luther University Halle Wittenberg, Halle, Germany
    Anticancer Drugs 17:69-74. 2006
    ..The correlation between the increase in coronary resistance and the decrease in vasoconstrictor responsiveness may suggest that these anthracyclines act through a common cellular mechanism...
  97. ncbi Characterization of four different effects elicited by H2O2 in rat aorta
    José Gil-Longo
    Department of Pharmacology, Faculty of Pharmacy, Universidade de Santiago de Compostela, Santiago de Compostela, Spain
    Vascul Pharmacol 43:128-38. 2005
    ....
  98. ncbi Induces vasodilatation of rat mesenteric artery in vitro mainly by inhibiting receptor-mediated Ca(2+)-influx and Ca(2+)-release
    Yong xiao Cao
    Department of Pharmacology, Medical School of Xi an Jiaotong University, No 76, Yanta West Road, Xi an, Shaanxi Province 710061, P R China
    Arch Pharm Res 28:709-15. 2005
    ..Our results suggest that atropine-induced vasodilatation is mainly from artery smooth muscle cells due to inhibition of the receptor-mediated Ca(2+)-influx and Ca(2+)-release, and partly from the endothelium mediated by EDHF...
  99. ncbi Phenotypic modifications of vascular smooth muscle cells could be responsible for vascular hyporeactivity to contracting agent in mechanically injured rat carotid artery
    A Popolo
    Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo, 84084 Fisciano SA, Italy
    Atherosclerosis 183:213-21. 2005
    ....
  100. ncbi Vasorelaxant effect of the flavonoid galangin on isolated rat thoracic aorta
    Silvana Morello
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    Life Sci 78:825-30. 2006
    ....
  101. ncbi The cardiovascular depression caused by bee venom in Sprague-Dawley rats associated with a decrease of developed pressure in the left ventricular and the ratio of ionized calcium/ionized magnesium
    Hyung Sub Kang
    Department of Pharmacology and Toxicology, College of Veterinary Medicine, Bio Safety Research Institute, Chonbuk National University, Center for the Healthcare Technology Development, Jeonju 561 756, Republic of Korea
    Am J Chin Med 36:505-16. 2008
    ..These results suggest that BV induces cardiovascular depression by decreasing the cardiac pressure and increasing the ionized magnesium concentration in the blood...

Research Grants63

  1. Using Drosophila to understand WNK and SPAK/OSR1 regulation of SLC12 cotransporte
    AYLIN RACHEL RODAN; Fiscal Year: 2013
    ..This project seeks to better understand the molecular mechanisms by which these cotransporters work and how they are regulated, to improve understanding and treatment of high blood pressure and disorders of acid-base balance. ..
  2. Transcriptional Regulation of Natriuetic Sensitivity in Diabetes Mellitus
    PATIENCE O OBIH; Fiscal Year: 2012
    ..as indices of activity of sodium chloride co-transporter (NCC), sodium hydrogen exchanger (NHE) and sodium-potassium chloride cotransporter (NKCC), respectively...
  3. Inhibition of chloride secretion by cigarette smoke
    JAMES LEVIN KREINDLER; Fiscal Year: 2010
    ..End of Abstract) ..
  4. Bronchodilator Effects of Toll-Like Receptor-7 Agonists.
    David B Jacoby; Fiscal Year: 2011
    ..by methacholine, histamine, stimulation of parasympathetic nerves, and depolarization of smooth muscle by potassium chloride. Pharmacological studies using TLR7 antagonists, as well as studies in TLR7- deficient mice, demonstrate ..
  5. CELLULAR ELECTROPHYSIOLOGY OF THE SUPRACHIASMATIC NUCLEI
    Charles N Allen; Fiscal Year: 2011
    ..4) Examine the role of different KCC cotransporters in regulating the intracellular Clconcentration and GABA responses of SCN neurons. ..
  6. CELLULAR ELECTROPHYSIOLOGY OF THE SUPRACHIASMATIC NUCLEI
    Charles N Allen; Fiscal Year: 2013
    ..4) Examine the role of Cl- efflux as regulated by KCC cotransporters in modulating the magnitude and polarity of GABAA receptor-mediated synaptic transmission. ..
  7. HORMONAL CONTROL OF UTERINE MUSCLE K-CHANNEL MRNA
    Mary Boyle; Fiscal Year: 1992
    ..Finally, the effect of suppressing translation of the K channel mRNA on the transformation of electrical properties by estrogen will be examined using hybrid-arrest techniques in myometrial cells treated with estrogen in vitro...
  8. PREVENTION OF STROKE DYSFUNCTION BY ACE INHIBITION
    CHARLES STIER; Fiscal Year: 2003
    ..We will also examine the interrelationship between mineralocorticoids and increased potassium chloride intake...
  9. MECHANISM OF THE NA, K- ION TRANSPORT ATPASE
    Robert Post; Fiscal Year: 1990
    ..The reactivity of the radioactive phosphoenzyme will be assessed by its response to adenosine diphosphate or potassium chloride added during a chase of unlabeled adenosine triphosphate...
  10. STUDY OF HUMAN MULTIPLE MYELOMA CELL ANTIGENS
    Malcolm MacKenzie; Fiscal Year: 1980
    ..Antigens will be isolated and characterized by means of potassium chloride extraction gel chromatography, ion exchange chromatography and polyacrylamide gel electrophoresis...
  11. MECHANISMS OF HUMAN CORONARY ARTERIOLAR DILATION
    David Gutterman; Fiscal Year: 2001
    ..However, presence of potassium chloride does prevent flow-mediated dilation...
  12. Sciatic ligation, spinal plasticity and neuropathic pain
    Gordana Miletic; Fiscal Year: 2010
    ..Second, from a therapeutic perspective, we seek to achieve better target specificity for more effective future therapeutic interventions. ..
  13. PROPAGATION OF INJURY DUE TO FOCAL CEREBRAL ISCHEMIA
    Philip Weinstein; Fiscal Year: 1999
    ..The induction of SD and ID by potassium chloride or ischemia will be correlated with induction of c-fos immediate early gene and D-MRI; regions in the ..
  14. REGULATE CA-2+ FOLLOWING ACTIVATION OF NMDA RECEPTOR
    AMY MACDERMOTT; Fiscal Year: 1991
    ..The experiments in this proposal will provide new, direct information on a previously incompletely described component of the response to glutamate; elevation of intracellular calcium...
  15. CALCIUM-DEPENDENT SURVIVAL OF DEVELOPING NEURONS
    Zixu Mao; Fiscal Year: 2004
    ..Membrane depolarizing concentrations of extracellular potassium chloride mimics neuronal activity in vivo to promote survival of neonatal cerebellar granule neurons...
  16. Mechanisms for inhibition of neurotransmitter release by the G protein Galphao
    Andrew Bellemer; Fiscal Year: 2009
    ..A better understanding of the mechanisms by which G proteins signal may provide a better understanding of how these processes are regulated. ..
  17. LKS AND LKUR IN GRANULOSA CELLS
    Lisa Freeman; Fiscal Year: 2003
    ..GC IKs and IKur may represent either novel targets for assisted reproduction, or potential sites of toxicity for drugs designed to treat arrhythmias, asthma, incontinence, immunosuppression or epilepsy. ..
  18. EFFECTS OF NUTRIENTS IN HYPERTENSION
    ROSE ROBERTSON; Fiscal Year: 1993
    ..Repeated determination of baseline measures are performed at four and eight weeks to define both the extent and time course of these effects and to provide insight into their potential mechanisms...
  19. REGULATION OF DETRUSOR SMOOTH MUSCLE CONTRACTION
    PAUL RATZ; Fiscal Year: 2005
    ..Collectively, these studies will provide new insights into the cellular mechanisms regulating DSM contractions. ..
  20. Regulation of vascular smooth muscle calcium sensitivity
    Paul H Ratz; Fiscal Year: 2010
    ..The Specific Aim of this study will be to test the hypothesis that ROK and PKCzeta both mediate KCI- induced Ca sensitization of FA, and that iPLA2 and PI3K are required as upstream activators of ROK and PKCzeta. ..
  21. Sexual dimorphism in seizure control is KCC2 mediated
    ARISTEA GALANOPOULOU; Fiscal Year: 2007
    ..Albert Einstein College of Medicine will offer the necessary mentoring, laboratory space, equipment and training opportunities to achieve these goals. ..
  22. Calcium signaling in airway smooth muscle in lung slices
    Michael Sanderson; Fiscal Year: 2007
    ..abstract_text> ..
  23. CALCIUM SIGNALING IN AIRWAY EPITHELIA AND SMOOTH MUSCLE
    Michael Sanderson; Fiscal Year: 2002
    ..With this understanding our ability to design therapies to counter obstructive lung disease and prevent asthmatic attacks will be enhanced. ..
  24. The regulation of airway ciliary activity
    Michael Sanderson; Fiscal Year: 2005
    ..abstract_text> ..
  25. Targeting Tumor Angiogenesis with G-Quadruplex Binders
    Daekyu Sun; Fiscal Year: 2010
    ..abstract_text> ..
  26. DNA LIGASE I AS A POTENTIAL TARGET FOR ANTICANCER DRUGS
    Daekyu Sun; Fiscal Year: 2002
    ..3) Test whether DNA ligase I inhibition produces antitumor activity using antisense strategy in preclinical in vitro and in vivo evaluation systems. 4) Develop a sensitive and reproducible assay for DNA ligase I. ..
  27. TRAINING IN SMOOTH AND CARDIAC MUSCLE BIOLOGY
    Richard Paul; Fiscal Year: 2003
    ..This arrangement promotes scientific interactions and enhance the breadth of educational and research experiences in our cardiovascular training program. ..
  28. Septate junctional proteins: Proteomic identification and role in diuresis
    KLAUS BEYENBACH; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  29. NA-PUMP ISOFORM-SPECIFIC REGULATION OF VASCULAR FUNCTION
    Richard Paul; Fiscal Year: 2004
    ..The applicant will test the hypotheses that these isoforms are independently regulated and that the observed glucose-sensitivity of activation of vascular smooth muscle is a consequence of NKA alpha-isoform distribution. ..
  30. A cell-free system for exocytosis in the beta-cell
    SUSANNE STRAUB SHARP; Fiscal Year: 2005
    ..physiological mechanisms such as time-dependent potentiation and biphasic insulin release. The method will also allow the study of some aspects of endocytosis. ..
  31. Kinetic Intermediates in Folding of Histone Dimers
    Lisa M Gloss; Fiscal Year: 2010
    ..When these processes go awry because of misregulation of nucleosome function, assembly and dynamics, disease states result, particularly cancer. ..
  32. REGULATION OF RENAL VASCULAR CELLS IN HYPERTENSION
    CRAIG GELBAND; Fiscal Year: 2001
    ....
  33. Endothelial Function in the Cerebral Circulation
    Frank Faraci; Fiscal Year: 2009
    ..These studies should provide new insight into mechanisms of cerebral vascular protection during hypertension. ..
  34. Mathematical Model of Vascular and Tubular Transport in the Rat Outer Medulla
    AURELIE EDWARDS; Fiscal Year: 2008
    ..We will simulate the effects of renal perfusion pressure-induced elevations in medullary CO concentrations on mTAL sodium reabsorption, so as to gain some insight into the mechanisms underlying pressure natriuresis. ..
  35. PHYSICOCHEMICAL INVESTIGATION OF TASTE
    Vijay Lyall; Fiscal Year: 2010
    ..The research will reveal how the sour taste defense mechanism functions to prevent the ingestion of acids. ..
  36. Chronic hypoxia and pulmonary vascular smooth muscle
    Larissa A Shimoda; Fiscal Year: 2010
    ..Understanding the cellular changes that occur in the pulmonary vasculature with development of pulmonary hypertension is key to advancing treatment and therapeutic options. ..
  37. MOLECULAR PHARMACOLOGY OF VOLTAGE SENSITIVE NA CHANNELS
    Edward Moczydlowski; Fiscal Year: 2001
    ..These biophysical studies will allow us deduce the functional contribution of key residues that determine ionic selectivity and unitary conductance of the NaV channel pore. ..
  38. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2007
    ..This understanding may be key to learning how we can further manipulate their participation in renal fibrosis. ..
  39. Chemokine Receptor Chimeras by Synthetic Gene Library
    Michael Dustin; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  40. Serum Proteins Influencing Helicobacter pylori Growth
    TRACI TESTERMAN; Fiscal Year: 2007
    ..A more complete understanding of serum proteins interacting with bacteria could lead to advancements in cultivation of other organisms as well. ..
  41. MECHANISMS FOR ALTERED DETRUSOR CONTRACTILITY IN DIABET
    Samuel Chacko; Fiscal Year: 2002
    ..An understanding of the molecular events that lead to contractile dysfunctions in diabetes is crucial in order to target the molecular steps for the development for pharmacological gents to treat diabetic cystopathy. ..
  42. MECHANISM OF KINESIN ATPASE
    David Hackney; Fiscal Year: 2002
    ..These enzymatic studies will be coupled with study of the motility that kinesin is able to produce. A long range goal is to be able to model the physical properties of kinesin based on its solution biochemical mechanism, ..
  43. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  44. NFAT and MEF-2 Choreograph Bladder Wall Remodeling Following Partial Outlet Obstr
    STEPHEN ANTHONY ZDERIC; Fiscal Year: 2010
    ..New therapy to preserve and enhance native bladder function will help avoid the development of the end stage bladder. ..
  45. MYOCARDIAL CALCIUM HANDLING DURING AND AFTER HYPOTHERMIA
    DAVID STOWE; Fiscal Year: 2002
    ..These studies will lead to a better understanding of Ca2+ loading and therapies to protect hypothermic hearts. ..
  46. EXOCYTOSIS & MEMBRANE TRAFFICKING IN NEUROENDOCRINE CELL
    Joseph Angleson; Fiscal Year: 2003
    ..abstract_text> ..
  47. DEFECTIVE ALPHA, ADRENERGIC SIGNALING IN SENESCENT RAT
    DONNA KORZICK; Fiscal Year: 2003
    ..Environment: The environment surrounding Dr. Korzick at the University of Missouri is one marked by a commitment to research and academic scholarship with major strengths in cardiovascular sciences. ..
  48. Regulation of Kv2.1 Trafficking
    KRISTEN O CONNELL; Fiscal Year: 2005
    ..Therefore understanding of this process will contribute to our knowledge of how membrane excitability is regulated. ..
  49. NO-CGMP INHIBITION OF UROGENITAL SMOOTH MUSCLE
    Christopher Rembold; Fiscal Year: 2004
    ....
  50. Calcium, Dairy, and Body Fat in Adolescents
    Connie Weaver; Fiscal Year: 2006
    ..This study will evaluate calcium/dairy as a modulator of energy balance, important to the management of body fat in children. ..
  51. Regulation of Pancreas Development by P13K/Akt Signaling
    Ernesto Bernal Mizrachi; Fiscal Year: 2006
    ..abstract_text> ..
  52. CALCIUM METABOLISM IN ASIAN GIRLS AND POSTMENOPAUSAL WOMEN
    Connie Weaver; Fiscal Year: 2006
    ..Optimizing calcium retention during periods of rapid growth is a key nutritional strategy to build peak bone mass and reduce lifelong risk of osteoporosis. ..
  53. NADPH oxidases-associated transition from Barrett's esophagus to adenocarcinoma
    Weibiao Cao; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  54. Polymer Carrier for Ischemia-Inducible Gene Therapy
    David Bull; Fiscal Year: 2007
    ..abstract_text> ..
  55. PRESYNAPTIC MECHANISMS IN THE INTESTINE
    James Galligan; Fiscal Year: 2008
    ..It is also anticipated that these studies will identify new targets for drugs that can be used to treat GI motility disorders. ..
  56. Enhanced cardiac sympathetic afferent reflex in CHF
    Wei Wang; Fiscal Year: 2004
    ....
  57. Immunoreceptors
    Michael Dustin; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  58. MYOSIN ISOFORM FUNCTION IN VASCULAR SMOOTH MUSCLE
    Anne Martin; Fiscal Year: 2003
    ..These experiments will provide crucial information on the role of myosin isoforms in cardiovascular function in both physiological and pathological circumstances. ..
  59. Prostaglandins: Kinins and Angiotensin Interactions
    JOHN MC GIFF; Fiscal Year: 2009
    ..3) Heme oxygenase activity and suppression of EET and 20-HETE synthesis. 4) Activation of peroxisome-proliferator-activated receptor alpha by Fibrates with stimulation of EET synthesis. ..