phosphates

Summary

Summary: Inorganic salts of phosphoric acid.

Top Publications

  1. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
  2. pmc PHO2, microRNA399, and PHR1 define a phosphate-signaling pathway in plants
    Rajendra Bari
    Max Planck Institute for Molecular Plant Physiology, Science Park Golm, 14476 Potsdam, Germany
    Plant Physiol 141:988-99. 2006
  3. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
  4. ncbi A miRNA involved in phosphate-starvation response in Arabidopsis
    Hiroaki Fujii
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, Riverside, California 92521, USA
    Curr Biol 15:2038-43. 2005
  5. ncbi RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates
    Andreas Pichlmair
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 314:997-1001. 2006
  6. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
  7. pmc pho2, a phosphate overaccumulator, is caused by a nonsense mutation in a microRNA399 target gene
    Kyaw Aung
    Institute of BioAgricultural Sciences, Academia Sinica, Taipei 115, Taiwan, Republic of China
    Plant Physiol 141:1000-11. 2006
  8. ncbi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
    J Bone Miner Res 19:429-35. 2004
  9. ncbi The role of nutrient availability in regulating root architecture
    José López-Bucio
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500 Irapuato, Guanajuato, Mexico
    Curr Opin Plant Biol 6:280-7. 2003
  10. ncbi Mortality in kidney disease patients treated with phosphate binders: a randomized study
    Biagio Di Iorio
    Department of Nephrology, Ospedale A Landolfi di Solofra, Avellino, Italy
    Clin J Am Soc Nephrol 7:487-93. 2012

Research Grants

Detail Information

Publications266 found, 100 shown here

  1. pmc Fibroblast growth factor 23 and mortality among patients undergoing hemodialysis
    ORLANDO M GUTIERREZ
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, USA
    N Engl J Med 359:584-92. 2008
    ..Hyperphosphatemia and low 1,25-dihydroxyvitamin D levels are associated with mortality among patients with chronic kidney disease, but the effect of the level of FGF-23 on mortality is unknown...
  2. pmc PHO2, microRNA399, and PHR1 define a phosphate-signaling pathway in plants
    Rajendra Bari
    Max Planck Institute for Molecular Plant Physiology, Science Park Golm, 14476 Potsdam, Germany
    Plant Physiol 141:988-99. 2006
    ....
  3. pmc Fibroblast growth factor 23 and left ventricular hypertrophy in chronic kidney disease
    ORLANDO M GUTIERREZ
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Circulation 119:2545-52. 2009
    ..We conducted a cross-sectional study to test the hypothesis that elevated FGF-23 concentrations are associated with left ventricular hypertrophy and coronary artery calcification in patients with CKD...
  4. ncbi A miRNA involved in phosphate-starvation response in Arabidopsis
    Hiroaki Fujii
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, Riverside, California 92521, USA
    Curr Biol 15:2038-43. 2005
    ..The results suggest that miRNAs have functional roles for plants to cope with fluctuations in mineral-nutrient availability in the soil...
  5. ncbi RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates
    Andreas Pichlmair
    Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK
    Science 314:997-1001. 2006
    ..does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I ..
  6. pmc Klotho deficiency causes vascular calcification in chronic kidney disease
    Ming Chang Hu
    Charles and Jane Pak Center for Mineral Metabolism and Clinical Research, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390 8885, USA
    J Am Soc Nephrol 22:124-36. 2011
    ..Klotho ameliorates vascular calcification by enhancing phosphaturia, preserving glomerular filtration, and directly inhibiting phosphate uptake by vascular smooth muscle. Replacement of Klotho may have therapeutic potential for CKD...
  7. pmc pho2, a phosphate overaccumulator, is caused by a nonsense mutation in a microRNA399 target gene
    Kyaw Aung
    Institute of BioAgricultural Sciences, Academia Sinica, Taipei 115, Taiwan, Republic of China
    Plant Physiol 141:1000-11. 2006
    ..This observation not only provides important insight into the interaction between miR399 and UBC24 mRNA, but also supports their systemic function in Pi translocation and remobilization...
  8. ncbi FGF-23 is a potent regulator of vitamin D metabolism and phosphate homeostasis
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Ltd, Takasaki, Gumma, Japan
    J Bone Miner Res 19:429-35. 2004
    ..This study indicates that FGF-23 is a potent regulator of the vitamin D and phosphate metabolism...
  9. ncbi The role of nutrient availability in regulating root architecture
    José López-Bucio
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500 Irapuato, Guanajuato, Mexico
    Curr Opin Plant Biol 6:280-7. 2003
    ..Progress in this field has led to the cloning of regulatory genes that play pivotal roles in nutrient-induced changes to root development...
  10. ncbi Mortality in kidney disease patients treated with phosphate binders: a randomized study
    Biagio Di Iorio
    Department of Nephrology, Ospedale A Landolfi di Solofra, Avellino, Italy
    Clin J Am Soc Nephrol 7:487-93. 2012
    ....
  11. ncbi Involvement of OsSPX1 in phosphate homeostasis in rice
    Chuang Wang
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, China
    Plant J 57:895-904. 2009
    ..This suggests that OsSPX1 acts via a negative feedback loop to optimize growth under phosphate-limited conditions...
  12. pmc MicroRNA399 is a long-distance signal for the regulation of plant phosphate homeostasis
    Bikram Datt Pant
    Max Planck Institute for Molecular Plant Physiology, Science Park Golm, Am Muhlenberg 1, 14476 Potsdam, Germany
    Plant J 53:731-8. 2008
    ..Hence the transported miR399 molecules retain biological activity. This is a demonstration of systemic control of a biological process, i.e. maintenance of plant Pi homeostasis, by a phloem-mobile microRNA...
  13. ncbi Association of elevated serum PO(4), Ca x PO(4) product, and parathyroid hormone with cardiac mortality risk in chronic hemodialysis patients
    S K Ganesh
    Division of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48103, USA
    J Am Soc Nephrol 12:2131-8. 2001
    ..More vigorous measures to reduce the prevalence of these factors in HD patients may result in improved survival...
  14. pmc Cloning and characterization of FGF23 as a causative factor of tumor-induced osteomalacia
    T Shimada
    Pharmaceutical Research Laboratory, Nephrology, Kirin Brewery Co Ltd, 3 Miyahara, Takasaki, Gunma 370 1295, Japan
    Proc Natl Acad Sci U S A 98:6500-5. 2001
    ..We conclude that overproduction of FGF23 causes TIO, whereas mutations in the FGF23 gene result in autosomal dominant hypophosphatemic rickets possibly by preventing proteolytic cleavage and enhancing biological activity of FGF23...
  15. pmc Loss of DMP1 causes rickets and osteomalacia and identifies a role for osteocytes in mineral metabolism
    Jian Q Feng
    Oral Biology, University of Missouri Kansas City, Kansas City, Missouri 64108, USA
    Nat Genet 38:1310-5. 2006
    ..Our findings suggest a bone-renal axis that is central to guiding proper mineral metabolism...
  16. ncbi Phosphate regulation of vascular smooth muscle cell calcification
    S Jono
    Department of Bioengineering, University of Washington, Seattle, WA 98195, USA
    Circ Res 87:E10-7. 2000
    ..The full text of this article is available at http://www.circresaha.org...
  17. pmc Effects of phosphate binders in moderate CKD
    Geoffrey A Block
    Denver Nephrology, 130 Rampart Way, Suite 300B, Denver, CO 80230, USA
    J Am Soc Nephrol 23:1407-15. 2012
    ..The safety and efficacy of phosphate binders in CKD remain uncertain...
  18. ncbi Fibroblast growth factor 23 (FGF23) predicts progression of chronic kidney disease: the Mild to Moderate Kidney Disease (MMKD) Study
    Danilo Fliser
    Department of Internal Medicine, Hannover Medical School, Germany
    J Am Soc Nephrol 18:2600-8. 2007
    ..In conclusion, FGF23 is a novel independent predictor of progression of renal disease in patients with nondiabetic CKD. Its pathophysiological significance remains to be elucidated...
  19. pmc FGF23 neutralization improves chronic kidney disease-associated hyperparathyroidism yet increases mortality
    Victoria Shalhoub
    Department of Metabolic Disorders, Amgen Inc, Thousand Oaks, CA, USA
    J Clin Invest 122:2543-53. 2012
    ..Thus, mineral disturbances caused by neutralization of FGF23 limited the efficacy of FGF23-Ab and likely contributed to the increased mortality observed in this CKD-MBD rat model...
  20. ncbi Nitrate and phosphate availability and distribution have different effects on root system architecture of Arabidopsis
    Birgit I Linkohr
    Department of Biology, University of York, UK
    Plant J 29:751-60. 2002
    ..The auxin-resistant mutants axrl, axr4 and aux1 all showed the wild-type lateral root elongation responses to a nitrate-rich patch, suggesting that auxin is not required for this response...
  21. ncbi Relation between serum phosphate level and cardiovascular event rate in people with coronary disease
    Marcello Tonelli
    Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    Circulation 112:2627-33. 2005
    ..Given the biological importance of phosphorus, it is plausible that higher levels of serum phosphate within the normal range may also be associated with adverse outcomes...
  22. pmc Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease
    Tamara Isakova
    Division of Nephrology and Hypertension, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    Kidney Int 79:1370-8. 2011
    ..Hence, FGF23 measurements may be a sensitive early biomarker of disordered phosphorus metabolism in patients with CKD and normal serum phosphate levels...
  23. pmc A conserved MYB transcription factor involved in phosphate starvation signaling both in vascular plants and in unicellular algae
    V Rubio
    Centro Nacional de Biotecnologia, Campus de Cantoblanco, 28049 Madrid, Spain
    Genes Dev 15:2122-33. 2001
    ..PHR1-binding sequences are present in the promoter of Pi starvation-responsive structural genes, indicating that this protein acts downstream in the Pi starvation signaling pathway...
  24. pmc Phosphate availability alters lateral root development in Arabidopsis by modulating auxin sensitivity via a mechanism involving the TIR1 auxin receptor
    Claudia Anahí Pérez-Torres
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, 36821 Irapuato, Guanajuato, Mexico
    Plant Cell 20:3258-72. 2008
    ....
  25. pmc Regulation of phosphate homeostasis by MicroRNA in Arabidopsis
    Tzyy Jen Chiou
    Institute of BioAgricultural Sciences, Academia Sinica, Taipei 115, Taiwan, Republic of China
    Plant Cell 18:412-21. 2006
    ..These results provide evidence that miRNA controls Pi homeostasis by regulating the expression of a component of the proteolysis machinery in plants...
  26. ncbi Phosphate: the new cholesterol? The role of the phosphate axis in non-uremic vascular disease
    Timothy J Ellam
    Department of Cardiovascular Science, Sheffield University, Medical School, Beech Hill Road, Sheffield S10 2RX, United Kingdom
    Atherosclerosis 220:310-8. 2012
    ..Since interventions are already available to manipulate the phosphate axis, this is an important issue. If an atherogenic role for phosphate exposure is demonstrated then phosphate binders could become the new statins...
  27. pmc Identification and characterization of the Arabidopsis PHO1 gene involved in phosphate loading to the xylem
    Dirk Hamburger
    Institut d Ecologie Biologie et Physiologie Végétales, Batiment de Biologie, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Plant Cell 14:889-902. 2002
    ..The Arabidopsis genome contains 10 additional genes showing homology with PHO1. Thus, PHO1 defines a novel class of proteins involved in ion transport in plants...
  28. pmc Characterization of the rice PHO1 gene family reveals a key role for OsPHO1;2 in phosphate homeostasis and the evolution of a distinct clade in dicotyledons
    David Secco
    Département de Biologie Moléculaire Végétale, Biophore, Universite de Lausanne, CH 1015 Lausanne, Switzerland
    Plant Physiol 152:1693-704. 2010
    ..Furthermore, phylogenetic analysis of PHO1 homologs in monocotyledons and dicotyledons revealed the emergence of a distinct clade of PHO1 genes in dicotyledons, which include members having roles other than long-distance Pi transport...
  29. pmc Regulation and function of the FGF23/klotho endocrine pathways
    Aline Martin
    University of Tennessee Health Science Center, Memphis, Tennessee, USA
    Physiol Rev 92:131-55. 2012
    ..This review discusses the known and emerging functions of FGF23, its regulation in response to systemic and local signals, as well as the implications of FGF23 in different pathological and physiological contexts...
  30. ncbi Two rice phosphate transporters, OsPht1;2 and OsPht1;6, have different functions and kinetic properties in uptake and translocation
    Penghui Ai
    State Key Laboratory of Crop Genetics and Germplasm Enhancement, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing, China
    Plant J 57:798-809. 2009
    ..Taken together, these data suggest OsPT6 plays a broad role in Pi uptake and translocation throughout the plant, whereas OsPT2 is a low-affinity Pi transporter, and functions in translocation of the stored Pi in the plant...
  31. ncbi Phosphate transport in Arabidopsis: Pht1;1 and Pht1;4 play a major role in phosphate acquisition from both low- and high-phosphate environments
    Heungsop Shin
    The Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Plant J 39:629-42. 2004
    ..Thus, Pht1;1 and Pht1;4 play significant roles in Pi acquisition from both low- and high-Pi environments...
  32. pmc Klotho: a novel phosphaturic substance acting as an autocrine enzyme in the renal proximal tubule
    Ming Chang Hu
    Department of Internal Medicine, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390 8885, USA
    FASEB J 24:3438-50. 2010
    ....
  33. ncbi Root developmental adaptation to phosphate starvation: better safe than sorry
    Benjamin Peret
    UMR 6191 CEA, Centre National de la Recherche Scientifique, Laboratoire de Biologie du Développement des Plantes, Universite d Aix Marseille, 13108 Saint Paul Lez Durance, France
    Trends Plant Sci 16:442-50. 2011
    ..Such an improvement is needed in order to adjust how we manage limited phosphorus stocks and to reduce the disastrous environmental effects of phosphate fertilizers overuse...
  34. pmc FGF-23: More than a regulator of renal phosphate handling?
    Harald Juppner
    Endocrine Unit and Pediatric Nephrology Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    J Bone Miner Res 25:2091-7. 2010
    ..Nonetheless, reducing the production and/or the biologic activity of FGF-23 may be an important therapeutic goal for this patient population...
  35. ncbi Direct evidence for a causative role of FGF23 in the abnormal renal phosphate handling and vitamin D metabolism in rats with early-stage chronic kidney disease
    Hisashi Hasegawa
    Innovative Drug Research Laboratories, Kyowa Hakko Kirin, Tokyo, Japan
    Kidney Int 78:975-80. 2010
    ....
  36. ncbi OsSPX1 suppresses the function of OsPHR2 in the regulation of expression of OsPT2 and phosphate homeostasis in shoots of rice
    Fang Liu
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310058, China
    Plant J 62:508-17. 2010
    ..This finding provides new insight into the regulatory mechanism of Pi uptake, translocation, allocation and homeostasis in plants...
  37. ncbi Inorganic polyphosphate: essential for growth and survival
    Narayana N Rao
    Department of Biochemistry, Stanford University School of Medicine, Stanford, CA 94305, USA
    Annu Rev Biochem 78:605-47. 2009
    ..Beyond the immediate relevance of Poly P as a target for anti-infective drugs, a large variety of cellular operations that rely on Poly P will be considered...
  38. ncbi Circulating concentration of FGF-23 increases as renal function declines in patients with chronic kidney disease, but does not change in response to variation in phosphate intake in healthy volunteers
    Tobias Larsson
    Department of Medical Sciences, University Hospital, Uppsala, Sweden
    Kidney Int 64:2272-9. 2003
    ..We therefore hypothesized that FGF-23 levels may be altered in hyperphosphatemia associated with renal failure and that its concentration changes in response to different levels of phosphate intake...
  39. pmc Phosphate feeding induces arterial medial calcification in uremic mice: role of serum phosphorus, fibroblast growth factor-23, and osteopontin
    Mohga M El-Abbadi
    Department of Bioengineering, University of Washington, Seattle, Washington 98195, USA
    Kidney Int 75:1297-307. 2009
    ..These findings suggest that phosphate loading and the severity of uremia play critical roles in controlling arterial medial calcification in mice. Further, FGF-23 and osteopontin may be markers and/or inducers of this process...
  40. pmc Phosphate availability alters architecture and causes changes in hormone sensitivity in the Arabidopsis root system
    José López-Bucio
    Departamento de Ingeniería Genética de Plantas, Centro de Investigacion y de Estudios Avanzados del Instituto Politecnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500 Irapuato, Guanajuato, Mexico
    Plant Physiol 129:244-56. 2002
    ..These results suggest that in Arabidopsis, auxin sensitivity may play a fundamental role in the modifications of root architecture by P availability...
  41. ncbi The phosphate regulon and bacterial virulence: a regulatory network connecting phosphate homeostasis and pathogenesis
    Martin G Lamarche
    Groupe de Recherche sur les Maladies Infectieuses du Porc, Faculte de Medecine Veterinaire, Universite de Montreal, Saint Hyacinthe, Quebec, Canada
    FEMS Microbiol Rev 32:461-73. 2008
    ..The Pho regulon is clearly not a simple regulatory circuit for controlling phosphate homeostasis; it is part of a complex network important for both bacterial virulence and stress response...
  42. pmc WRKY75 transcription factor is a modulator of phosphate acquisition and root development in Arabidopsis
    Ballachanda N Devaiah
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, Indiana 47907 1165, USA
    Plant Physiol 143:1789-801. 2007
    ..WRKY75 is the first member of the WRKY transcription factor family reported to be involved in regulating a nutrient starvation response and root development...
  43. pmc Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism
    Takashi Shimada
    Pharmaceutical Research Laboratories, Kirin Brewery Co, Takasaki, Gunma, Japan
    J Clin Invest 113:561-8. 2004
    ..These phenotypes could not be explained by currently known regulators of mineral homeostasis, indicating that FGF23 is essential for normal phosphate and vitamin D metabolism...
  44. pmc Contribution of strigolactones to the inhibition of tiller bud outgrowth under phosphate deficiency in rice
    Mikihisa Umehara
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 230 0045 Japan
    Plant Cell Physiol 51:1118-26. 2010
    ....
  45. pmc Coexpression-based clustering of Arabidopsis root genes predicts functional modules in early phosphate deficiency signaling
    Wen Dar Lin
    Institute of Plant and Microbial Biology, Academia Sinica, 115 Taipei, Taiwan
    Plant Physiol 155:1383-402. 2011
    ..The combined results provide a novel, integrated view at a systems level of the root responses that acclimate Arabidopsis (Arabidopsis thaliana) to suboptimal Pi levels...
  46. ncbi Pathophysiology of vascular calcification in chronic kidney disease
    Sharon M Moe
    Indiana University School of Medicine, Wishard Memorial Hospital, 1001 W 10th St, OPW 526 Indianapolis, IN 46202, USA
    Circ Res 95:560-7. 2004
    ..This nidus can then mineralize if the balance of pro-mineralizing factors outweighs inhibitory factors...
  47. ncbi Phosphate starvation induces a determinate developmental program in the roots of Arabidopsis thaliana
    Lenin Sánchez-Calderón
    Departamento de Ingeniería Genética, Centro de Investigacion y Estudios Avanzados del Instituto Politecnico Nacional, Unidad Irapuato, Apartado Postal 629, 36500 Irapuato, Guanajuato, Mexico
    Plant Cell Physiol 46:174-84. 2005
    ..These results suggest that in Arabidopsis, P limitation can induce a determinate root developmental program that plays an important role in altering root system architecture and that the QC could act as a sensor of environmental signals...
  48. pmc Effect of phosphate binders on serum inflammatory profile, soluble CD14, and endotoxin levels in hemodialysis patients
    Juan F Navarro-González
    Research Unit, University Hospital Nuestra Senora de Candelaria, 38010 Santa Cruz de Tenerife, Spain
    Clin J Am Soc Nephrol 6:2272-9. 2011
    ..We evaluated the effects of calcium acetate and sevelamer hydrochloride on serum inflammatory profile, endotoxin concentrations, and sCD14 levels in HD patients...
  49. pmc Update on fibroblast growth factor 23 in chronic kidney disease
    Myles Wolf
    Department of Medicine, Division of Nephrology and Hypertension, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Kidney Int 82:737-47. 2012
    ..The report concludes with a critical review of the effects of different therapeutic strategies targeting FGF23 reduction and how these might be leveraged in a future randomized trial aimed at improving outcomes in CKD...
  50. ncbi Signaling network in sensing phosphate availability in plants
    Tzyy Jen Chiou
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan
    Annu Rev Plant Biol 62:185-206. 2011
    ..In this review, we outline the current knowledge on this subject and present hypotheses pertaining to other potential signals and to the organization and coordination of signaling...
  51. pmc Elastin degradation and vascular smooth muscle cell phenotype change precede cell loss and arterial medial calcification in a uremic mouse model of chronic kidney disease
    Ashwini Pai
    Department of Bioengineering, University of Washington, Seattle, Washington, USA
    Am J Pathol 178:764-73. 2011
    ....
  52. pmc A role for auxin redistribution in the responses of the root system architecture to phosphate starvation in Arabidopsis
    Philippe Nacry
    Laboratoire de Biochimie and Physiologie Moléculaire des Plantes, Unité Mixte de Recherche 5004, Institut National de la Recherche Agronomique, Universite Montpellier 2, F 34060 Montpellier Cedex 1, France
    Plant Physiol 138:2061-74. 2005
    ....
  53. pmc The Arabidopsis SUMO E3 ligase SIZ1 controls phosphate deficiency responses
    Kenji Miura
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, IN 47907, USA
    Proc Natl Acad Sci U S A 102:7760-5. 2005
    ..These results indicate that AtSIZ1 is a SUMO E3 ligase and that sumoylation is a control mechanism that acts both negatively and positively on different Pi deficiency responses...
  54. ncbi Molecular regulators of phosphate homeostasis in plants
    Wei Yi Lin
    Agricultural Biotechnology Research Center, Academia Sinica, Taipei, Taiwan, ROC
    J Exp Bot 60:1427-38. 2009
    ..In the future, integration of current knowledge and exploration of new technology is expected to offer new insights into molecular mechanisms that maintain Pi homeostasis...
  55. ncbi Root tip contact with low-phosphate media reprograms plant root architecture
    Sergio Svistoonoff
    Laboratoire de Biologie du Développement des Plantes, Département d Ecophysiologie Végétale et de Microbiologie, Unité Mixte de Recherche 6191 Commissariat à l Energie Atomique CEA, Centre National de la Recherche Scientifique CNRS, Cedex, France
    Nat Genet 39:792-6. 2007
    ..LPR1 and LPR2 encode multicopper oxidases (MCOs), highlighting the essential role of MCOs for plant development...
  56. ncbi Human vascular smooth muscle cells undergo vesicle-mediated calcification in response to changes in extracellular calcium and phosphate concentrations: a potential mechanism for accelerated vascular calcification in ESRD
    Joanne L Reynolds
    Department of Medicine, Addenbrooke s Hospital, Cambridge, United Kingdom
    J Am Soc Nephrol 15:2857-67. 2004
    ..These vesicles contain mineralization inhibitors derived from VSMC and serum, and perturbation of the production or function of these inhibitors would lead to accelerated vascular calcification...
  57. ncbi Fibroblast growth factor-23 relationship to dietary phosphate and renal phosphate handling in healthy young men
    Serge L Ferrari
    Service of Bone Diseases, Geneva University Hospital, 24 Rue Micheli du Crest, Geneva 1211, Switzerland
    J Clin Endocrinol Metab 90:1519-24. 2005
    ..These data suggest that FGF-23 may be implicated in the physiological regulation of Pi homeostasis in response to dietary phosphate changes, independent of PTH...
  58. ncbi Human fibroblast growth factor-23 mutants suppress Na+-dependent phosphate co-transport activity and 1alpha,25-dihydroxyvitamin D3 production
    Hitoshi Saito
    Pharmaceutical Laboratory II, Chugai Pharmaceutical Co, Ltd, Shizuoka 412 8513, Japan
    J Biol Chem 278:2206-11. 2003
    ..Taken together, the FGF23 mutants reduce both phosphate uptake in intestine and phosphate reabsorption in kidney, independent of PTH action...
  59. ncbi The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria
    Susan Chalmers
    Buck Institute for Age Research, Novato, California 94945, USA
    J Biol Chem 278:19062-70. 2003
    ..The solubility product of amorphous Ca3(PO4)2 is consistent with the observed matrix free calcium concentration, and the matrix pH is proposed to play the major role in maintaining the low matrix free calcium concentration...
  60. pmc Phosphate starvation triggers distinct alterations of genome expression in Arabidopsis roots and leaves
    Ping Wu
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Sciences, Zhejiang University, Hangzhou, 310029, China
    Plant Physiol 132:1260-71. 2003
    ....
  61. ncbi Transcriptional regulation and functional properties of Arabidopsis Pht1;4, a high affinity transporter contributing greatly to phosphate uptake in phosphate deprived plants
    Julie Misson
    CEA Cadarache, DSV DEVM Laboratoire de Biologie du Développement des Plantes, UMR 6191 CNRS CEA, Aix Marseille II, F 13108 Saint Paul lez Durance Cedex, France
    Plant Mol Biol 55:727-41. 2004
    ..The work described here offers a first step in the complex genetic dissection of the phosphate transport system in planta...
  62. ncbi Tomato strigolactones are derived from carotenoids and their biosynthesis is promoted by phosphate starvation
    Juan Antonio Lopez-Raez
    Plant Research International, P O Box 16, NL 6700 AA Wageningen, The Netherlands
    New Phytol 178:863-74. 2008
    ..The dual activity of these signalling compounds in attracting beneficial AM fungi and detrimental parasitic plants is further strengthened by environmental conditions such as phosphate availability...
  63. ncbi Inorganic polyphosphate: a molecule of many functions
    A Kornberg
    Department of Biochemistry, Stanford University School of Medicine, California 94305 5307, USA
    Annu Rev Biochem 68:89-125. 1999
    ..Practical interest in poly P includes many industrial applications, among which is the microbial removal of Pi in aquatic environments...
  64. pmc Genome-wide analysis of the Arabidopsis leaf transcriptome reveals interaction of phosphate and sugar metabolism
    Renate Müller
    Plant Biochemistry Laboratory, Department of Plant Biology, Royal Veterinary and Agricultural University, DK 1871 Frederiksberg C, Denmark
    Plant Physiol 143:156-71. 2007
    ..PHR1 binding sites were more frequent in promoters of P-regulated genes as compared to the entire Arabidopsis genome, and E2F and PHR1 binding sites were more frequent in interaction clusters 1 and 3, respectively...
  65. ncbi Structural basis for 5'-end-specific recognition of guide RNA by the A. fulgidus Piwi protein
    Jin Biao Ma
    Structural Biology Program, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Nature 434:666-70. 2005
    ....
  66. ncbi Global transcriptional analysis of the phosphate starvation response in Sinorhizobium meliloti strains 1021 and 2011
    E Krol
    Lehrstuhl fur Genetik, Fakultat fur Biologie, Universitat Bielefeld, Postfach 100131, 33501, Bielefeld, Germany
    Mol Genet Genomics 272:1-17. 2004
    ..This mutation is probably responsible for the expression of phosphate starvation-inducible genes in Rm1021 in the absence of phosphate stress...
  67. pmc Targeted inactivation of Npt2 in mice leads to severe renal phosphate wasting, hypercalciuria, and skeletal abnormalities
    L Beck
    Departments of Pediatrics and Human Genetics, McGill University, Montreal Children s Hospital Research Institute, Montreal, PQ, Canada H3H 1P3
    Proc Natl Acad Sci U S A 95:5372-7. 1998
    ..Our findings demonstrate that Npt2 is a major regulator of Pi homeostasis and necessary for normal skeletal development...
  68. ncbi Genome streamlining in a cosmopolitan oceanic bacterium
    Stephen J Giovannoni
    Department of Microbiology, Oregon State University, Corvallis, OR 97331, USA
    Science 309:1242-5. 2005
    ..P. ubique has no pseudogenes, introns, transposons, extrachromosomal elements, or inteins; few paralogs; and the shortest intergenic spacers yet observed for any cell...
  69. ncbi Reduction of Mo(VI) by the bacterium Serratia sp. strain DRY5
    M F A Rahman
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, UPM 43400 Serdang, Selangor, Malaysia
    J Environ Biol 30:65-72. 2009
    ..The characteristics of isolate DRY5 suggest that it would be useful in the bioremediation ofmolybdenum-containing waste...
  70. ncbi Klotho in health and disease
    Makoto Kuro-o
    Department of Pathology, The University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390 9072, USA
    Curr Opin Nephrol Hypertens 21:362-8. 2012
    ....
  71. ncbi Molybdate reduction by Pseudomonas sp. strain DRY2
    M Y Shukor
    Department of Biochemistry, Faculty of Biotechnology and Biomolecular Sciences, University Putra Malaysia, Serdang, Selangor, Malaysia
    J Appl Microbiol 108:2050-8. 2010
    ..To isolate and characterize a potent molybdenum-reducing bacterium...
  72. ncbi Mutational analysis of putative phosphate- and proton-binding sites in the Saccharomyces cerevisiae Pho84 phosphate:H(+) transceptor and its effect on signalling to the PKA and PHO pathways
    Dieter R Samyn
    School of Natural Sciences, Linnaeus University, SE 391 82 Kalmar, Sweden
    Biochem J 445:413-22. 2012
    ....
  73. pmc The Arabidopsis purple acid phosphatase AtPAP10 is predominantly associated with the root surface and plays an important role in plant tolerance to phosphate limitation
    Liangsheng Wang
    The Ministry of Education Key Laboratory of Bioinformatics, School of Life Sciences, Tsinghua University, Beijing 100084, China
    Plant Physiol 157:1283-99. 2011
    ..Genetic manipulation of AtPAP10 expression may provide an effective means for engineering new crops with increased tolerance to Pi deprivation...
  74. ncbi Loss of At4 function impacts phosphate distribution between the roots and the shoots during phosphate starvation
    Heungsop Shin
    The Samuel Roberts Noble Foundation, 2510 Sam Noble Parkway, Ardmore, OK 73401, USA
    Plant J 45:712-26. 2006
    ....
  75. ncbi Phosphate homeostasis and the renal-gastrointestinal axis
    Joanne Marks
    Dept of Neuroscience, Physiology, and Pharmacology, Univ College London Medical School, UK
    Am J Physiol Renal Physiol 299:F285-96. 2010
    ....
  76. pmc Phosphate starvation promotes swarming motility and cytotoxicity of Pseudomonas aeruginosa
    Manjeet Bains
    Centre for Microbial Diseases and Immunity Research, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada
    Appl Environ Microbiol 78:6762-8. 2012
    ..This dysregulation also led to increased virulence-associated phenotypes, including swarming motility and cytotoxicity...
  77. ncbi Regulation of C-terminal and intact FGF-23 by dietary phosphate in men and women
    Sherri Ann M Burnett
    Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    J Bone Miner Res 21:1187-96. 2006
    ..Dietary phosphate is a key regulator of circulating FGF-23; choice of assay is critical when studying FGF-23 physiology...
  78. ncbi Patients with autosomal dominant polycystic kidney disease have elevated fibroblast growth factor 23 levels and a renal leak of phosphate
    Ivana Pavik
    Institute of Physiology and Zurich Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland
    Kidney Int 79:234-40. 2011
    ..The mechanism for this anomaly will require further study...
  79. pmc Global regulation by the seven-component Pi signaling system
    Yi Ju Hsieh
    Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA
    Curr Opin Microbiol 13:198-203. 2010
    ..We describe a revised model for P(i) signal transduction of the E. coli Pho regulon...
  80. ncbi Fibroblast growth factor-23 is associated with C-reactive protein, serum phosphate and bone mineral density in chronic kidney disease
    P Manghat
    Department of Chemical Pathology, 5th Floor, North Wing, St Thomas Hospital, Lambeth Palace Road, London, SE1 7EH, UK
    Osteoporos Int 21:1853-61. 2010
    ..C-reactive protein (CRP) and serum phosphate correlated with FGF-23. A significant association was seen between FGF-23 and BMD at the hip...
  81. pmc The parathyroid is a target organ for FGF23 in rats
    Iddo Z Ben-Dov
    Minerva Center for Calcium and Bone Metabolism, Nephrology Services, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Invest 117:4003-8. 2007
    ..These data indicate that FGF23 acts directly on the parathyroid through the MAPK pathway to decrease serum PTH. This bone-parathyroid endocrine axis adds a new dimension to the understanding of mineral homeostasis...
  82. ncbi Compensatory regulation of the sodium/phosphate cotransporters NaPi-IIc (SCL34A3) and Pit-2 (SLC20A2) during Pi deprivation and acidosis
    Ricardo Villa-Bellosta
    Laboratory of Molecular Toxicology, Veterinary Faculty, University of Zaragoza, Calle Miguel Servet 177, 50013 Zaragoza, Spain
    Pflugers Arch 459:499-508. 2010
    ..5 and 60% of Pi transport at pH 6.0, depending on the pH and the physiological conditions...
  83. pmc Phosphate is essential for inhibition of the mitochondrial permeability transition pore by cyclosporin A and by cyclophilin D ablation
    Emy Basso
    Department of Biomedical Sciences and Consiglio Nazionale delle Ricerche Institute of Neuroscience, University of Padova, Viale Giuseppe Colombo 3, I 35121 Padova, Italy
    J Biol Chem 283:26307-11. 2008
    ..These findings call for a reassessment of conclusions on the role of the PTP in cell death that are based on the effects of CsA or of CyP-D ablation...
  84. pmc Mapping of the minimal inorganic phosphate transporting unit of human PiT2 suggests a structure universal to PiT-related proteins from all kingdoms of life
    Pernille Bøttger
    Department of Molecular Biology, Aarhus University, C F Møllers Allé 3, Aarhus C, DK 8000, Denmark
    BMC Biochem 12:21. 2011
    ..We have here exploited the dual-function of PiT1 and PiT2 to study the structure-function relationship of PiT proteins...
  85. ncbi Microarray analysis of phosphate regulation in the marine cyanobacterium Synechococcus sp. WH8102
    Sasha G Tetu
    Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, New South Wales, Australia
    ISME J 3:835-49. 2009
    ..Interestingly, however, the exact composition and arrangement of the Pho regulon appears highly variable in marine cyanobacteria...
  86. pmc Phosphate availability regulates root system architecture in Arabidopsis
    L C Williamson
    Department of Biology, University of York, Box 373, York YO10 5YW, United Kingdom
    Plant Physiol 126:875-82. 2001
    ..In contrast, shoot phosphate status was found to influence the root system architecture response to phosphate availability...
  87. ncbi Characterization of a sub-family of Arabidopsis genes with the SPX domain reveals their diverse functions in plant tolerance to phosphorus starvation
    Ke Duan
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310058, China
    Plant J 54:965-75. 2008
    ..Our results indicate that both AtSPX1 and AtSPX3 play positive roles in plant adaptation to phosphate starvation, and AtSPX3 may have a negative feedback regulatory role in AtSPX1 response to phosphate starvation...
  88. pmc In vivo genetic evidence for klotho-dependent, fibroblast growth factor 23 (Fgf23) -mediated regulation of systemic phosphate homeostasis
    Teruyo Nakatani
    Department of Developmental Biology, Harvard School of Dental Medicine, 188 Longwood Ave, Boston, MA 02115, USA
    FASEB J 23:433-41. 2009
    ..Together, these results provide compelling evidence that Fgf23 does not have a klotho-independent role in the regulation of systemic phosphate and vitamin D homeostasis...
  89. pmc Phosphate starvation root architecture and anthocyanin accumulation responses are modulated by the gibberellin-DELLA signaling pathway in Arabidopsis
    Caifu Jiang
    State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, National Centre for Plant Gene Research, Beijing 100101, China
    Plant Physiol 145:1460-70. 2007
    ..Pi starvation causes a reduction in bioactive GA level, which, in turn, causes DELLA accumulation, thus modulating several adaptively significant plant Pi starvation responses...
  90. pmc OsPHR2 is involved in phosphate-starvation signaling and excessive phosphate accumulation in shoots of plants
    Jie Zhou
    State Key Laboratory of Plant Physiology and Biochemistry, College of Life Science, Zhejiang University, Hangzhou 310058, China
    Plant Physiol 146:1673-86. 2008
    ..The mechanism behind the OsPHR2 regulated Pi accumulation will provide useful approaches to develop smart plants with high Pi efficiency...
  91. pmc Phosphate starvation responses and gibberellic acid biosynthesis are regulated by the MYB62 transcription factor in Arabidopsis
    Ballachanda N Devaiah
    Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907 1165, USA
    Mol Plant 2:43-58. 2009
    ..Such cross-talk between Pi homeostasis and GA might have broader implications on flowering, root development and adaptive mechanisms during nutrient stress...
  92. pmc Mycorrhizal fungi can dominate phosphate supply to plants irrespective of growth responses
    Sally E Smith
    Centre for Plant Root Symbioses, Soil and Land Systems, School of Earth and Environmental Sciences, Waite Campus, The University of Adelaide, PMB1, Glen Osmond, South Australia, Australia 5064
    Plant Physiol 133:16-20. 2003
  93. ncbi Regulation of phosphate homeostasis by PTH, vitamin D, and FGF23
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital, Boston, MA 02114, USA
    Annu Rev Med 61:91-104. 2010
    ..Most insights gained into the regulation of phosphate homeostasis by these factors are derived from human genetic disorders and genetically engineered mice, which are reviewed in this paper...
  94. ncbi Calcium-phosphate levels and cardiovascular disease in community-dwelling adults: the Atherosclerosis Risk in Communities (ARIC) Study
    Robert N Foley
    United States Renal Data System, Minneapolis, MN 55404, USA
    Am Heart J 156:556-63. 2008
    ..Calcium-phosphate levels, linked to vascular dysfunction in chronic kidney disease, may represent novel risk factors for coronary heart disease, stroke, and death in community-dwelling adults...
  95. pmc Red death in Caenorhabditis elegans caused by Pseudomonas aeruginosa PAO1
    Alexander Zaborin
    Department of Surgery, Pritzker School of Medicine, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:6327-32. 2009
    ..In summary, red death in C. elegans reveals a triangulated response between PhoB, MvfR-PQS, and pyoverdin in response to phosphate depletion that activates a lethal phenotype in P. aeruginosa...
  96. pmc Changes in gene expression in Arabidopsis shoots during phosphate starvation and the potential for developing smart plants
    John P Hammond
    Horticulture Research International, Wellesbourne, Warwick CV35 9EF, United Kingdom
    Plant Physiol 132:578-96. 2003
    ..Transferring this technology to crops would allow precision management of P fertilization, thereby maintaining yields while reducing costs, conserving natural resources, and preventing pollution...
  97. pmc Phosphate availability affects the thylakoid lipid composition and the expression of SQD1, a gene required for sulfolipid biosynthesis in Arabidopsis thaliana
    B Essigmann
    Institut für Genbiologische Forschung Berlin GmbH, Ihnestrasse 63, 14195 Berlin, Germany
    Proc Natl Acad Sci U S A 95:1950-5. 1998
    ..thaliana. It is suggested that a certain amount of anionic thylakoid lipid is maintained by substituting sulfolipid for phosphatidylglycerol under reduced phosphate availability...
  98. pmc Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP
    Antonio Rodríguez-García
    Instituto de Biotecnologia de Leon, INBIOTEC, Parque Cientifico de Leon, Av Real, 1, 24006, Leon, Spain
    Nucleic Acids Res 37:3230-42. 2009
    ..A mutant deleted in PhoP showed increased expression of the nitrogen metabolism genes. The possible conservation of phosphate control over nitrogen metabolism in other microorganisms is discussed...
  99. pmc SLC34A3 mutations in patients with hereditary hypophosphatemic rickets with hypercalciuria predict a key role for the sodium-phosphate cotransporter NaPi-IIc in maintaining phosphate homeostasis
    Clemens Bergwitz
    Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Am J Hum Genet 78:179-92. 2006
    ..We conclude that NaP(i)-IIc has a key role in the regulation of phosphate homeostasis...
  100. pmc Early control of PTH and FGF23 in normophosphatemic CKD patients: a new target in CKD-MBD therapy?
    Rodrigo B Oliveira
    Nephrology Department, Universidade de Sao Paulo, Sao Paulo, Brazil
    Clin J Am Soc Nephrol 5:286-91. 2010
    ..This short-term 6-wk dose titration study evaluated the effect of two phosphate binders on PTH and FGF23 levels in patients with CKD stages 3 to 4...
  101. pmc A genome-wide transcriptional analysis using Arabidopsis thaliana Affymetrix gene chips determined plant responses to phosphate deprivation
    Julie Misson
    Laboratoire de Biologie du Développement des Plantes, Unite Mixte de Recherche 6191, Centre National de la Recherche Scientifique Commissariat à l Energie Atomique, Aix Marseille II, 13108 Saint Paul Lez Durance, France
    Proc Natl Acad Sci U S A 102:11934-9. 2005
    ..The results not only enhance our knowledge about molecular processes associated with Pi deficiency, but also facilitate the identification of key molecular determinants for improving Pi use by crop species...

Research Grants66

  1. Iron in the pathogenesis of Friedreich's ataxia
    ARNULF HANS WERNER KOEPPEN; Fiscal Year: 2013
    ..In addition to suboptimal biosynthesis of high-energy phosphates, lack of frataxin also heightens sensitivity to oxidative stress, presumed to be mediated by free or loosely ..
  2. Resuscitation of smoke inhalation and burn injury with a thioredoxin mimetic
    ANDREW LURIE SALZMAN; Fiscal Year: 2012
    ..In severe instances, the ultimate exhaustion of high energy phosphates (ATP) triggers cellular necrosis and the functional loss of the alveolocapillary membrane...
  3. N-Glycosylation And ER Stress
    MARK LEHRMAN; Fiscal Year: 2012
    ..This Aim will: determine how stress-induced hexose phosphates elevate nucleotide-sugar pools;identify steps in LLO synthesis responsive to nucleotide-sugar control;and ..
  4. Dietary Regulation of Pancreatic Digestive Enzymes
    John A Williams; Fiscal Year: 2013
    ..We have shown this growth requires the calcium activated phosphates calcineurin and the mTOR pathway, and is accompanied by the activation of the MAP kinases, ERK and JNK, and the ..
  5. A NEW TECHNIQUE FOR TREATING HEMORRHAGIC SHOCK
    Sufan Chien; Fiscal Year: 2013
    ..Depletion of high-energy phosphates during hemorrhagic shock was described decades ago, and direct administration of free Mg-ATP was reported to ..
  6. MYOCARDIAL PERFUSION IN THE HYPERTROPHIED HEART
    ROBERT JAMES BACHE; Fiscal Year: 2010
    ..heart that are associated with abnormalities of myocardial energy metabolism, including loss of high energy phosphates (HEP), decreased myocardial oxygen consumption (MV02), and impaired maximal oxidative capacity...
  7. Metabolism and toxicity of NRTIs in non-replicating tissues
    Edward E McKee; Fiscal Year: 2013
    ..This goal will be accomplished by: 1) Determining the conversion of radioactive NRTIs to their tri-phosphates in mitochondria isolated from a variety of rat tissues, in the perfused heart, and in vivo in a variety of rat ..
  8. Studies of Isoprenoid Biosynthesis
    CHARLES DALE POULTER; Fiscal Year: 2013
    ..the development of mutants capable of efficiently synthesizing longer chain diphosphates from the corresponding phosphates. (2) Isoforms of IPP isomerase (IDI1 and IDI2) convert IPP to DMAPP by a proton-initiated process...
  9. Cations and ROS in Modulating Mitochondrial Function in Normal and Ischemic Heart
    Ranjan K Dash; Fiscal Year: 2013
    ..g., Ca2+) are governed by a dynamic buffering mechanism due to dynamic binding of the cations with phosphates (ATP, ADP, PI) and substrates (TCA cycle intermediates) during transient respiration, which in turn regulate ..
  10. Engineering a packaging nanomotor for delivery of RNA and other molecules
    Venigalla B Rao; Fiscal Year: 2010
    ..charged residues lining the groove follows the pitch of the double helix;interacting with the backbone phosphates. These features suggest that the packaging motor is amendable to design novel motors with altered specificity...
  11. Immunotherapeutic Potential of Modified Lipooligosaccharides and Lipid A's
    Robert K Ernst; Fiscal Year: 2013
    ..Additionally, synthetic lipid A mimetics aminoalkyl glucosaminide phosphates (AGPs) that also signal through Toll-Like Receptor 4 (TLR4) are being studied as both adjuvants or stand-alone ..
  12. Human Embryonic Stem Cells in Calcium Phosphate Constructs for Bone Regeneration
    HUAKUN XU; Fiscal Year: 2013
    ..However, there has been no report on the use of hESCs for bone tissue engineering via injectable calcium phosphates. While human bone marrow mesenchymal stem cells (hBMSCs) are useful, their harvest requires an invasive ..
  13. Regulation of DRP1-Mediated Mitochondrial Fragmentation in Ischemic Brain Injury
    Andrew Slupe; Fiscal Year: 2012
    ..My long term goal is to characterize the regulatory interaction between the calcium-dependent protein phosphates calcineurin (CaN) and Drp1...
  14. Connecting metabolic stress and cell physiology in Escherichia coli
    GREGORY ROSS RICHARDS; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): Bacterial cells experience stress when they accumulate sugar-phosphates, and the ways in which bacteria deal with this stress have only recently begun to be characterized...
  15. The Inositol Phosphate Cascade as a Regulator of FSH and LH actions in the Ovary
    Shawn M Breen; Fiscal Year: 2012
    ..receptor densities do not support aromatase expression because they also stimulate the accumulation of inositol phosphates and diacylglycerol leading to the release of epiregulin and phosphorylation of EGFR and ERK1/2...
  16. Functional Subdomain Organization of the Recycling Endosome
    David R Sheff; Fiscal Year: 2010
    ..We hypothesize that phosphatidylinositol 3-phosphates regulate membrane traffic and sorting within the recycling endosome...
  17. Development of a HTS-assay for inhibitors of a type 2C protein phosphatase (PPM
    Richard E Honkanen; Fiscal Year: 2010
    ..In contrast, much less is known about the biology of protein phosphates. Notably the biological roles and pathology associated with phosphates belonging to the PP2C subfamily are ..
  18. Role of Endocannabinoids in Levodopa-Induced Dyskinesias
    Andrea Giuffrida; Fiscal Year: 2012
    ..agonist WIN55212-2;it will focus on the cross talk between CB1 and TRPV1 receptors and the role played by the phosphates calcineurin and DARPP-32 in this interaction...
  19. Functional Evaluation of Somah Technology for Heart Transplant
    HEMANT SADASHIV THATTE; Fiscal Year: 2013
    ..solution extracts atmospheric oxygen at physiological concentrations and facilitates synthesis of high-energy phosphates, even at hypothermic preservation, thus preventing cellular damage due to ischemia and energy depletion during ..
  20. MULTIDISCIPLINARY STRUCTURES AT VASCULAR CELL SURFACES
    Timothy A Springer; Fiscal Year: 2013
    ..signaling at focal adhesions and explores activation of the tyrosine kinase of FAK by phosphatidylinositol phosphates through use of structures, cell biology, and small molecules...
  21. Phosphorylation of Prion Protein as a novel mechanism for conversion
    Andrea C LeBlanc; Fiscal Year: 2010
    ..The present application examines one possible mechanism that would explain the conversion of prion protein and offer new avenues for the prevention or treatment of prion diseases. ..
  22. MEASUREMENT OF FREE RADICAL GENERATION IN THE HEART
    JAY LOUIS ZWEIER; Fiscal Year: 2010
    ..Measurements of radical generation will be correlated with alterations in contractile function, high energy phosphates, and the metabolic state of the heart. Cell death will be measured by enzyme release and histology...
  23. Cellular/Molecular Analysis of Short &Long-Term Memory
    TERRY J CROW; Fiscal Year: 2013
    ..These studies in conjunction with MS analysis will provide evidence for both de novo synthesis and post-translational modifications of identified proteins contributing to the induction and maintenance of long-term memory. ..
  24. Spinophilin Signaling in the Striatum
    Anthony J Baucum; Fiscal Year: 2013
    ..Spinophilin is a scaffolding protein that binds protein phosphates 1 (PP1), F-actin, and several other proteins involved in regulating cell signaling and morphology...
  25. Osteogenic Calcium Phosphate Nanoparticles with Designable Drug Release Kinetics
    Vuk Uskoković; Fiscal Year: 2012
    ..The central hypothesis of the proposed study is that stoichiometry and the particle size of calcium phosphates can be used to tune the kinetics of the release of the encapsulated drug. Dr...
  26. KETONE BODY METABOLISM AND INTEGRATED METABOLIC HOMEOSTASIS
    Peter A Crawford; Fiscal Year: 2013
    ..depending on physiological state, ketones supply up to 40% of the carbon backbones that yield high-energy phosphates. While the adverse consequences of ketoacidosis are well-appreciated, experimental models to date have not ..
  27. Inferring gene regulatory circuitry from functional genomics data
    Harmen J Bussemaker; Fiscal Year: 2013
    ..shape that locally narrow the minor groove and enhance the electrostatic interaction between negative backbone phosphates of the DNA and positive amino-acid residues of DNase I...
  28. Biosensors of GPCR Activation & Inhibition for Drug Discovery
    RICHARD SCOTT STRUTHERS; Fiscal Year: 2010
    ..Cellular functional assays measuring the production of GPCR second messengers such as cAMP and inositol phosphates, are used routinely and remain conceptually unchanged since their introduction...
  29. Novel Inhibitors of Akt Signaling in Pancreatic Cancer
    Garth Powis; Fiscal Year: 2009
    ..is a modular structurally conserved protein superfold that binds to plasma membrane phosphoinositide (PtdIns)-3 phosphates causing the host proteins to move to the plasma membrane where they initiate signal transduction cascades ..
  30. Biomarker for Cognitive Impairment in Chronic Alcoholism
    RICHARD JAMES MCCLURE; Fiscal Year: 2011
    ..living subjects, specifically: 1) key aspects of membrane phospholipid metabolism;2) utilization of high-energy phosphates;3) dynamic aspects of protein phosphorylation - dephosphorylation;4) the number of brain synaptic and transport ..
  31. Role of Brain Specific Tyrosne Phosphatase STEP in Neuroprotection and Death
    Surojit Paul; Fiscal Year: 2013
    ..as the use of STEP KO mice and aging animals as tools to establish the neuroprotective potential of a tyrosine phosphates in ischemic brain injury is innovative...
  32. Innovation in the Prevention and Treatment of Early Childhood Caries
    Norman Tinanoff; Fiscal Year: 2013
    ..of antimicrobials (sugar alcohols, heavy metal, antiseptics) and remineralizing agents (fluoride, calcium phosphates, therapeutic restorative materials);effect of early interventions in medical settings;and result of delay of ..
  33. Biochemical markers of bone turnover in metastatic prostate cancer
    Primo N Lara; Fiscal Year: 2010
    ..markers of bone formation (osteocalcin, procollagen N-terminal propeptides: PINP &PIIINP, total alkaline phosphates) and resorption (N-telopeptide, pyridinoline, deoxypyridinoline) in serum had statistically significant ..
  34. Addiction and the Neuropharmacology of Psychostimulants
    Kathryn A Cunningham; Fiscal Year: 2013
    ..of the K05 Research Plan is that selective disrupters of the interface between the 5-HT2CR and PTEN (protein phosphates and tensin homologue deleted on chromosome 10) will augment 5-HT2CR signaling and provide therapeutic efficacy ..
  35. A NOVEL MECHANISM OF REGULATION OF INOSITOL BIOSYNTHESIS IN YEAST
    Miriam L Greenberg; Fiscal Year: 2012
    ..In yeast, inositol affects the transcription of over 700 genes. In addition, many inositol phosphates and phosphoinositides are signaling molecules that control essential cellular pathways...
  36. Structure and function of RNase P
    Michael E Harris; Fiscal Year: 2013
    ..In the last project period, we developed a means to detect and quantify metal ion interactions with RNA phosphates using Raman spectroscopy...
  37. Mechanism of mitotic exit in budding yeast
    Raymond Deshaies; Fiscal Year: 2009
    ..Early in mitosis, mitotic cyclin/CDK keeps its antagonists at bay by attaching inhibitory phosphates on Swi5 and Hctl...
  38. The role of polyphosphates in blood coagulation and inflammation
    SHARON HYONJU CHOI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polyphosphate (polyP) is a linear polymer of inorganic phosphates that is secreted by activated platelets and is abundant in many pathogenic microorganisms...
  39. Diphosphoinositol phosphate function revealed by chemical and genetic approaches
    Dorothea Fiedler; Fiscal Year: 2010
    ..messengers is an intriguing subgroup that possesses high energy diphosphate groups, namely the diphosphoinositol phosphates (or PP-IPs), which have recently been connected to several cellular functions, including vesicular trafficking ..
  40. The Biology of Inositol Polyphosphate Signaling
    John D York; Fiscal Year: 2012
    ..control of gene expression, growth control and cell death;and 2) understand the roles of diphosphoinositol phosphates, also known as inositol pyrophosphates, through studies of the exciting new evolutionarily conserved VIP1-like ..
  41. SYNTHESIS OF PHOSPHATE ESTERS WITH IODINE--III REAGENTS
    GERALD KOSER; Fiscal Year: 1990
    ..enol ethers, silyl ketene acetals, alkenes, conjugated dienes, alkynes and alkenoic acids with the iodine(III)-phosphates will provide a variety of new unnatural phosphate esters with considerable structural diversity...
  42. Bioenergetics and fatigability in older individuals
    Robert G Weiss; Fiscal Year: 2013
    ..with the NIA BLSA populations we propose to test the hypotheses that 1) at similar workloads, muscle high-energy phosphates are reduced and Pi increased in older subjects with high, as compared to those with low, fatigability, that 2) ..
  43. Chemoprevention via modulation of autophagy by sphingolipids
    ALFRED HARRISON MERRILL; Fiscal Year: 2010
    ..via autophagic cell death would be to favor the production of (DH)Cer and sphingoid bases over sphingoid base 1-phosphates. This intervention strategy will be explored using MCF7 cells that express GFP-tagged LC3 to facilitate the ..
  44. Effectors and regulators of end-dependent mRNA degradation in bacteria
    MONICA PING TING HUI; Fiscal Year: 2013
    ..was recently identified as the enzyme responsible for triggering 5'end-dependent degradation by removing phosphates from the 5'end of primary transcripts to produce short-lived 5'monophosphorylated decay intermediates;..
  45. Function of Myotubularin Phosphoinositide Phosphatase in Morphogenesis
    Amy A Kiger; Fiscal Year: 2012
    ..from dynamic spatial regulation, in part conveyed through localized regulation of specific phosphoinositide phosphates (PIPs) that define and control membrane compartment identities...
  46. Mechanisms of Cognitive Decline During Aging
    James W Simpkins; Fiscal Year: 2013
    ..Project 2 will determine the role of and mechanism by which insult-induced decline in protein phosphates results in persistent activation of a number of kinases, and oxidative stress that leads to AD-neuropathology ..
  47. GATING AND TRANSLOCATION IN THE DIPHTHERIA TOXIN CHANNEL
    Bruce Kagan; Fiscal Year: 1992
    ..Dose-response curves for IP3, other inositol phosphates and other DT ligands including blockers of stimulation (ApUp, ATP) will be constructed...
  48. Elucidating cellular signaling functions of diphosphoinositol polyphosphates
    Dorothea Fiedler; Fiscal Year: 2012
    ..messengers is an intriguing subgroup that possesses high energy diphosphate groups, namely the diphosphoinositol phosphates (PP...
  49. Molecular pathogenesis of calcineurin inhibitor-induced hypertension
    Chao Ling Yang; Fiscal Year: 2013
    ..Calcineurin is a protein phosphatase and we will test whether it removes phosphates from NCC directly, to inhibit its actions, or whether the pathway involves calcineurin acting on intermediar ..
  50. REACTIVE INTERMEDIATES OF ENZYMATIC REACTIONS
    John P Richard; Fiscal Year: 2012
    ..the transition state for formation of the enediol(ate) intermediate of the aldose-ketose isomerization of triose phosphates catalyzed by triose phosphate isomerase...
  51. High Strength Bioresorbable PLA/CaP Composites
    Tongxin Wang; Fiscal Year: 2013
    ..DESCRIPTION (provided by applicant): Bioresorbable composites made from degradable polymers and bioactive calcium phosphates are clinically desirable for bone fixation and repair, because they do not have to be removed by second surgery ..
  52. CHAPERONE-ASSISTED RNA CRYSTALLOGRAPHY - Resubmission 01
    JOSEPH ANTHONY PICCIRILLI; Fiscal Year: 2013
    ..stem in part from factors that confound lattice formation including the mutually repulsive negatively charged phosphates that decorate the surface of an RNA and the lack of diverse functional groups for mediating crystal contacts...
  53. INSULIN REGULATION OF CELL NUTRITION
    Konstantin V Kandror; Fiscal Year: 2013
    ..single entity with the help of GGA and ACAP-1 adaptors, small GTPases of the Arf family and phosphatidylinositol phosphates. In Specific Aim 1, we will test this hypothesis and further characterize the role of lumenal interactions in ..
  54. Regulatory Pathways of SR Protein Kinases
    Joseph Adams; Fiscal Year: 2013
    ..We showed that SRPKs and phosphatases work in opposite directions concentrating phosphates toward the C-terminal end of RS domains...
  55. Mechanisms of Tenofovir Renal Tubular Toxicity
    James J Kohler; Fiscal Year: 2010
    ..epithelial mitochondria with or without HIVAN;2) To determine DNC, OAT1, or MRP4 renal tubular transport of TDF phosphates;and 3) To determine the mechanisms of renal tubular toxicity of TDF-based combination antiretrovirals...
  56. NANOSTRUCTURED BIOACTIVE MATERIALS
    Laurence Chow; Fiscal Year: 2009
    ..Aim 3 will evaluate the effectiveness of nano sized calcium phosphates and calcium fluoride in reducing dentin permeability, a property closely associated with dental hypersensitivity...
  57. PARS inhibitor therapy of smoke inhalation injury
    Prakash Jagtap; Fiscal Year: 2001
    ..inhibition of glycolysis and mitochondrial respiration, and the ultimate reduction of intracellular high energy phosphates. PARS activation also strongly upregulates expression of pro-inflammatory cytokines, chemokines, and adhesion ..
  58. Characterization of a minimal "spliceosome"
    Saba Valadkhan; Fiscal Year: 2010
    ..the snRNAs in the spliceosome has revealed a functionally crucial role for a number of nucleobases and backbone phosphates. The molecular basis of the function of these required elements will be defined using nucleotide analog ..
  59. Organotrifluoroborates in Selective Organic Synthesis
    Gary A Molander; Fiscal Year: 2013
    ..complex, the electrophile (aryl, heteroaryl, alkenyl, alkynyl, alkyl), the nucleofuge (chlorides, sulfonates, phosphates), the solvent (e.g., water, ionic liquids), the bases required, and the conditions of the reaction (e.g...
  60. A Conjugated Polymer Fluorogenic Probe for Inorganic Polyphosphate
    JULIA ANN KALOW; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Polyphosphate (poly P) is a linear polymer of inorganic phosphates that is found in all living organisms, ranging from tens to hundreds of residues in length...
  61. MOLECULAR MECHANISM OF MATRIX PROTEIN PHOSPHORYLATION
    CHOU WU; Fiscal Year: 1993
    ..The addition of such phosphates to MPP during core-protein processing may be catalyzed by a novel membrane-bound enzyme, named matrix ..
  62. FRUCTOFURANOSE MODULATORS--STRUCTURAL/ENZYMATIC STUDIES
    EZZAT YOUNATHAN; Fiscal Year: 1992
    Fructofuranose phosphates have been shown to be important metabolic regulators particularly in carbohydrate metabolism. Scores of enzymes were shown to have allosteric sites for fructose 1,6- and 2,6-bisphosphates...
  63. INTERACTION AND ACTIVATION OF THE LH RECEPTOR
    TAE JI; Fiscal Year: 2005
    ..of LHR's interaction with hCG and generation of differential signals for second messengers, cAMP and inositol phosphates (IP)...
  64. Adjuvant Development
    David Johnson; Fiscal Year: 2013
    ..is developing a new class of potent lipid A-like immunomodulators known as aminoalkyl glucosaminide phosphates (AGPs)...
  65. REGIONAL FDG UPTAKE IN STUNNED VS HIBERNATING MYOCARDIUM
    Edward McFalls; Fiscal Year: 2000
    ..that within chronically hypoperfused myocardium, myocardium retains the capacity to regenerate high energy phosphates and glycogen stores...
  66. Liver Regeneration in Man--Effects or Adjuvant Therapy
    Yuman Fong; Fiscal Year: 2005
    ..the previous grant study period, we showed that characteristic changes in cellular phospholipids and high energy phosphates can be detected by MR spectroscopy in animals and be used as a surrogate marker for liver recovery in planning ..