oxides

Summary

Summary: Binary compounds of oxygen containing the anion O(2-). The anion combines with metals to form alkaline oxides and non-metals to form acidic oxides.

Top Publications

  1. ncbi The chemistry of graphene oxide
    Daniel R Dreyer
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712, USA
    Chem Soc Rev 39:228-40. 2010
  2. ncbi Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML
    Xiao Wei Zhang
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai 200025, China
    Science 328:240-3. 2010
  3. ncbi Graphene oxide as a chemically tunable platform for optical applications
    Kian Ping Loh
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
    Nat Chem 2:1015-24. 2010
  4. ncbi In vitro toxicity evaluation of graphene oxide on A549 cells
    Yanli Chang
    Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
    Toxicol Lett 200:201-10. 2011
  5. pmc PML targeting eradicates quiescent leukaemia-initiating cells
    Keisuke Ito
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 453:1072-8. 2008
  6. pmc PEGylated nanographene oxide for delivery of water-insoluble cancer drugs
    Zhuang Liu
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:10876-7. 2008
  7. ncbi Mechanisms of action of arsenic trioxide
    Wilson H Miller
    Lady Davis Institute for Medical Research and Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal H3T 1E2, Quebec, Canada
    Cancer Res 62:3893-903. 2002
  8. ncbi Graphene-based antibacterial paper
    Wenbing Hu
    Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, People s Republic of China
    ACS Nano 4:4317-23. 2010
  9. ncbi Acute promyelocytic leukemia: from highly fatal to highly curable
    Zhen Yi Wang
    Shanghai Institute of Hematology and State Key Laboratory of Medical Genomics, Riu Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai, China
    Blood 111:2505-15. 2008
  10. ncbi Antibacterial activity of two MTA-based root canal sealers
    R D Morgental
    Department of Endodontics, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Int Endod J 44:1128-33. 2011

Detail Information

Publications389 found, 100 shown here

  1. ncbi The chemistry of graphene oxide
    Daniel R Dreyer
    Department of Chemistry and Biochemistry, The University of Texas at Austin, 1 University Station, A5300, Austin, TX 78712, USA
    Chem Soc Rev 39:228-40. 2010
    ....
  2. ncbi Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML
    Xiao Wei Zhang
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai 200025, China
    Science 328:240-3. 2010
    ..The identification of PML as a direct target of As2O3 provides new insights into the drug's mechanism of action and its specificity for APL...
  3. ncbi Graphene oxide as a chemically tunable platform for optical applications
    Kian Ping Loh
    Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543
    Nat Chem 2:1015-24. 2010
    ..In this Review, we highlight the recent advances in optical properties of chemically derived GO, as well as new physical and biological applications...
  4. ncbi In vitro toxicity evaluation of graphene oxide on A549 cells
    Yanli Chang
    Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai 200444, China
    Toxicol Lett 200:201-10. 2011
    ..These effects are dose and size related, and should be considered in the development of bio-applications of GO. Overall, GO is a pretty safe material at cellular level, which is confirmed by the favorable cell growth on GO film...
  5. pmc PML targeting eradicates quiescent leukaemia-initiating cells
    Keisuke Ito
    Cancer Genetics Program, Beth Israel Deaconess Cancer Center, Department of Medicine, Harvard Medical School, New Research Building, 330 Brookline Avenue, Boston, Massachusetts 02215, USA
    Nature 453:1072-8. 2008
    ....
  6. pmc PEGylated nanographene oxide for delivery of water-insoluble cancer drugs
    Zhuang Liu
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:10876-7. 2008
    ..Our results showed that graphene is a novel class of material promising for biological applications including future in vivo cancer treatment with various aromatic, low-solubility drugs...
  7. ncbi Mechanisms of action of arsenic trioxide
    Wilson H Miller
    Lady Davis Institute for Medical Research and Sir Mortimer B Davis Jewish General Hospital, McGill University, Montreal H3T 1E2, Quebec, Canada
    Cancer Res 62:3893-903. 2002
    ..This information will be critical to realizing the potential for synergy between arsenic trioxide and other chemotherapeutic agents, thus providing enhanced benefit in cancer therapy...
  8. ncbi Graphene-based antibacterial paper
    Wenbing Hu
    Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, People s Republic of China
    ACS Nano 4:4317-23. 2010
    ....
  9. ncbi Acute promyelocytic leukemia: from highly fatal to highly curable
    Zhen Yi Wang
    Shanghai Institute of Hematology and State Key Laboratory of Medical Genomics, Riu Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Rui Jin Road II, Shanghai, China
    Blood 111:2505-15. 2008
    ..In this article, we review the history of introduction of ATRA and ATO into clinical use and the mechanistic studies in understanding this model of cancer targeted therapy...
  10. ncbi Antibacterial activity of two MTA-based root canal sealers
    R D Morgental
    Department of Endodontics, School of Dentistry, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS, Brazil
    Int Endod J 44:1128-33. 2011
    ..To evaluate the pH and antibacterial activity of Endo CPM Sealer and MTA Fillapex by two different methods, using white MTA and Endofill as references for comparison...
  11. ncbi Induction of autophagic cell death in malignant glioma cells by arsenic trioxide
    Takao Kanzawa
    Department of Neurosurgery, Mount Sinai School of Medicine, New York, New York 10029, USA
    Cancer Res 63:2103-8. 2003
    ..These findings suggest that As(2)O(3) at a clinically safe concentration may be an effective chemotherapeutic agent for malignant gliomas...
  12. ncbi Mineral trioxide aggregate: a comprehensive literature review--part II: leakage and biocompatibility investigations
    Mahmoud Torabinejad
    Endodontic Residency Program, Department of Endodontics, School of Dentistry, Loma Linda University, Loma Linda, California 92350, USA
    J Endod 36:190-202. 2010
    ..The purpose of part II of this review is to present a comprehensive list of articles regarding the sealing ability and biocompatibility of this material...
  13. ncbi Reduced graphene oxide by chemical graphitization
    In Kyu Moon
    Department of Chemistry, National Creative Research Initiative, Center for Smart Molecular Memory, Sungkyunkwan University, 300 Cheoncheon dong, Jangan gu, Suwon, Gyeonggi do 440 746, Republic of Korea
    Nat Commun 1:73. 2010
    Reduced graphene oxides (RG-Os) have attracted considerable interest, given their potential applications in electronic and optoelectronic devices and circuits...
  14. ncbi Curing APL through PML/RARA degradation by As2O3
    Valérie Lallemand-Breitenbach
    University Paris Diderot, Sorbonne Paris Cité, Hopital St Louis 1, avenue Claude Vellefaux, 75475 Paris, Cedex 10, France
    Trends Mol Med 18:36-42. 2012
    ..As discussed below, arsenic binding, oxidation, sumoylation on PML nuclear bodies, and RNF4-mediated ubiquitination all contribute to the As(2)O(3)-triggered catabolism of PML/RARA...
  15. pmc Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa
    Sangiliyandi Gurunathan
    Department of Animal Biotechnology, Konkuk University, Seoul, South Korea
    Int J Nanomedicine 7:5901-14. 2012
    ..To uncover the impacts of GO and rGO on human health, the antibacterial activity of two types of graphene-based material toward a bacterial model P. aeruginosa was studied and compared...
  16. ncbi Hydration mechanisms of mineral trioxide aggregate
    J Camilleri
    Department of Building and Civil Engineering, Faculty of Architecture and Civil Engineering, University of Malta, Msida, Malta
    Int Endod J 40:462-70. 2007
    ..To report the hydration mechanism of white mineral trioxide aggregate (White MTA, Dentsply, Tulsa Dental Products, Tulsa, OK, USA)...
  17. ncbi Physicochemical basis of the biologic properties of mineral trioxide aggregate
    N K Sarkar
    Operative Dentistry and Biomaterials Department, LSU, School of Dentistry, 1100 Florida Ave, New Orleans, LA 70119, USA
    J Endod 31:97-100. 2005
    ..The dentin-mineral trioxide aggregate interfacial layer results from a similar reaction. The sealing ability, biocompatibility, and dentinogenic activity of mineral trioxide aggregate is attributed to these physicochemical reactions...
  18. ncbi Toxicity of graphene and graphene oxide nanowalls against bacteria
    Omid Akhavan
    Department of Physics, Sharif University of Technology, P O Box 11155 9161, Tehran, Iran
    ACS Nano 4:5731-6. 2010
    ..The better antibacterial activity of the reduced nanowalls was assigned to the better charge transfer between the bacteria and the more sharpened edges of the reduced nanowalls, during the contact interaction...
  19. ncbi Reduction of graphene oxide via L-ascorbic acid
    Jiali Zhang
    National Key Laboratory of Micro Nano Fabrication Technology, Research Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, PR China
    Chem Commun (Camb) 46:1112-4. 2010
    ..This simple approach should find practical applications in large scale production of water soluble graphene...
  20. ncbi In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins
    G Q Chen
    Shanghai Institute of Hematology, Rui Jin Hospital, Department of Biophysics, Shanghai Second Medical University, P R China
    Blood 88:1052-61. 1996
    ..Moreover, this apoptosis induction occurs independently of the retinoid pathway and may be mediated, at least partly, through the modulation of bcl-2, as well as PML-RAR alpha and/ or PML proteins...
  21. ncbi Mineral trioxide aggregate: a comprehensive literature review--Part I: chemical, physical, and antibacterial properties
    Masoud Parirokh
    Department of Endodontics, School of Dentistry, Oral and Dental Diseases Research Center, Neuroscience Research Center, Iranian Center for Endodontic Research, Kerman University of Medical Sciences, Kerman, Iran
    J Endod 36:16-27. 2010
    ..The aim of Part I of this literature review is to present investigations regarding the chemical, physical, and antibacterial properties of MTA...
  22. ncbi Structural evolution during the reduction of chemically derived graphene oxide
    Akbar Bagri
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Nat Chem 2:581-7. 2010
    ..The calculations are supported by infrared and X-ray photoelectron spectroscopy measurements. Finally, more effective reduction treatments to improve the reduction of graphene oxide are proposed...
  23. ncbi Graphene oxide: a nonspecific enhancer of cellular growth
    Oscar N Ruiz
    Air Force Research Laboratory, Propulsion Directorate, Fuels and Energy Branch, Wright Patterson AFB, Ohio 45433, United States
    ACS Nano 5:8100-7. 2011
    ..Furthermore, graphene oxide acts as a general enhancer of cellular growth by increasing cell attachment and proliferation...
  24. ncbi Chemically derived graphene oxide: towards large-area thin-film electronics and optoelectronics
    Goki Eda
    Department of Materials, Imperial College London, UK
    Adv Mater 22:2392-415. 2010
    ..In this Review, the fundamental structure and properties of GO-based thin films are discussed in relation to their potential applications in electronics and optoelectronics...
  25. ncbi Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine in newly diagnosed chronic adult T-cell leukemia/lymphoma (ATL)
    Ghada Kchour
    Immunology Research Centre, Bu Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran
    Blood 113:6528-32. 2009
    ..Long-term follow up will clarify whether this will translate to disease cure. Overall, these clinical results strengthen the concept of oncogene-targeted cancer therapy...
  26. ncbi Effect of pH on sealing ability of white mineral trioxide aggregate as a root-end filling material
    Mohammad Ali Saghiri
    Department of Biomedical Engineering, Islamic Azad University, Tehran, Iran
    J Endod 34:1226-9. 2008
    ..4 followed by pH values of 5.4, 6.4, and 7.4, respectively. There was a significantly longer time necessary for leakage to occur in samples stored in higher pH values (P < .000)...
  27. pmc Respiration of metal (hydr)oxides by Shewanella and Geobacter: a key role for multihaem c-type cytochromes
    Liang Shi
    Pacific Northwest National Laboratory, Richland, Washington 99354, USA
    Mol Microbiol 65:12-20. 2007
    Dissimilatory reduction of metal (e.g. Fe, Mn) (hydr)oxides represents a challenge for microorganisms, as their cell envelopes are impermeable to metal (hydr)oxides that are poorly soluble in water...
  28. ncbi Characterization of biophysical and metabolic properties of cells labeled with superparamagnetic iron oxide nanoparticles and transfection agent for cellular MR imaging
    Ali S Arbab
    Experimental Neuroimaging Section, Laboratory of Diagnostic Radiology Research, National Institutes of Health, 10 Center Dr, Rm B1N256, Bethesda, MD 20892, USA
    Radiology 229:838-46. 2003
    ..To evaluate the effect of using the ferumoxides-poly-l-lysine (PLL) complex for magnetic cell labeling on the long-term viability, function, metabolism, and iron utilization of mammalian cells...
  29. doi Large-area ultrathin films of reduced graphene oxide as a transparent and flexible electronic material
    Goki Eda
    Nat Nanotechnol 3:270-4. 2008
    ..Collectively, our deposition method could represent a route for translating the interesting fundamental properties of graphene into technologically viable devices...
  30. ncbi Dissimilatory Fe(III) and Mn(IV) reduction
    Derek R Lovley
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Adv Microb Physiol 49:219-86. 2004
    ..Unlike other commonly considered electron acceptors, Fe(III) and Mn(IV) oxides, the most prevalent form of Fe(III) and Mn(IV) in most environments, are insoluble...
  31. ncbi Comparison of the root-end seal provided by bioceramic repair cements and White MTA
    F Leal
    Department of Endodontics, State University of Rio de Janeiro UERJ, Rio de Janeiro, Brazil
    Int Endod J 44:662-8. 2011
    ..To compare the ability of Ceramicrete, BioAggregate and white ProRoot MTA (mineral trioxide aggregate) to prevent glucose leakage through root-end fillings...
  32. ncbi Ex vivo cytotoxicity of a new calcium silicate-based canal filling material
    W Zhang
    Key Lab for Oral Biomedical Engineering of Ministry of Education, School of Stomatology, Wuhan University, Wuhan, China
    Int Endod J 43:769-74. 2010
    ..To evaluate the biocompatibility of iRoot SP root canal filling material to L929 mouse fibroblasts...
  33. ncbi Impact of arsenic trioxide in the treatment of acute promyelocytic leukemia
    E Lengfelder
    III Medizinische Universitätsklinik Mannheim, University of Heidelberg, Mannheim, Germany
    Leukemia 26:433-42. 2012
    ....
  34. ncbi Microbial reduction of graphene oxide by Escherichia coli: a green chemistry approach
    Sangiliyandi Gurunathan
    Department of Animal Biotechnology, Konkuk University, 1 Hwayang dong, Gwangin gu, Seoul 143 701, Republic of Korea
    Colloids Surf B Biointerfaces 102:772-7. 2013
    ..Our findings suggest that GO can be reduced by simple eco-friendly method by using E. coli biomass to produce water dispersible graphene...
  35. pmc Ultrasmall superparamagnetic iron oxides (USPIOs): a future alternative magnetic resonance (MR) contrast agent for patients at risk for nephrogenic systemic fibrosis (NSF)?
    Edward A Neuwelt
    Department of Neurology and Neurosurgery, Oregon Health and Science University, Portland, Oregon 97239, USA
    Kidney Int 75:465-74. 2009
    ..We conclude that for both CNS MR imaging and MR angiography, USPIO agents like ferumoxytol are a viable option for patients at risk for NSF...
  36. pmc Metal oxide gas sensors: sensitivity and influencing factors
    Chengxiang Wang
    Key Laboratory for Liquid Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan, 250061, China
    Sensors (Basel) 10:2088-106. 2010
    ..In this brief review, attention will be focused on changes of sensitivity of conductometric semiconducting metal oxide gas sensors due to the five factors mentioned above...
  37. ncbi Comparison of the physical and mechanical properties of MTA and portland cement
    Intekhab Islam
    Department of Restorative Dentistry, Faculty of Dentistry, National University of Singapore, Singapore
    J Endod 32:193-7. 2006
    ..Further in vitro and in vivo tests, especially with regards its biocompatibility, should be conducted to ascertain if it meets the FDA requirements for use as a medical device...
  38. ncbi Rat tissue reaction to MTA FILLAPEX®
    João Eduardo Gomes-Filho
    Department of Endodontics, Araçatuba School of Dentistry, University of Estadual Paulista, R Jose Bonifacio 1193, Aracatuba, Sao Paulo, Brazil
    Dent Traumatol 28:452-6. 2012
    ..Mineralization and granulation birefringent to polarized light were observed with all materials. It was concluded that MTA FILLAPEX® was biocompatible and stimulated mineralization...
  39. ncbi A multiparametric assay to compare the cytotoxicity of endodontic sealers with primary human osteoblasts
    M Z Scelza
    Laboratory of Experimental Cell Culture, Department of Endodontics, Fluminense Federal University UFF, Niteroi, RJ Brazil
    Int Endod J 45:12-8. 2012
    ....
  40. pmc Current production and metal oxide reduction by Shewanella oneidensis MR-1 wild type and mutants
    Orianna Bretschger
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, California 90089, USA
    Appl Environ Microbiol 73:7003-12. 2007
    ..S. oneidensis MR-1 can reduce Mn(IV) and Fe(III) oxides and can produce current in microbial fuel cells. The mechanisms that are employed by S...
  41. pmc Targeting thioredoxin reductase is a basis for cancer therapy by arsenic trioxide
    Jun Lu
    Medical Nobel Institute for Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institute, SE 17177 Stockholm, Sweden
    Proc Natl Acad Sci U S A 104:12288-93. 2007
    ..Blocking cancer cell DNA replication and repair and induction of oxidative stress by the inhibition of both Trx and GSH systems are suggested as cancer chemotherapeutic strategies...
  42. ncbi Arsenic trioxide stimulates SUMO-2/3 modification leading to RNF4-dependent proteolytic targeting of PML
    Stefan R Weisshaar
    Center for Molecular Medicine Cologne CMMC, Institute for Genetics, Zulpicher Strasse 47, 50674 Koln, Germany
    FEBS Lett 582:3174-8. 2008
    ..Polysumoylation of PML in response to ATO thus leads to its recognition and ubiquitylation by RNF4...
  43. ncbi Suppression of TG-interacting factor sensitizes arsenic trioxide-induced apoptosis in human hepatocellular carcinoma cells
    Zi Miao Liu
    Department of Medical Laboratory Science and Biotechnology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
    Biochem J 438:349-58. 2011
    ..Blockage of the PI3K/Akt pathway or TGIF expression combined with ATO treatment may be a promising strategy for HCC therapy...
  44. ncbi Arsenic trioxide induces not only apoptosis but also autophagic cell death in leukemia cell lines via up-regulation of Beclin-1
    Wenbin Qian
    Institute of Hematology, The First Affiliated Hospital, College of Medicine, Zhejiang University, 79 Qingchun Road, Hangzhou 310003, China
    Leuk Res 31:329-39. 2007
    ....
  45. pmc Therapy-induced selective loss of leukemia-initiating activity in murine adult T cell leukemia
    Hiba El Hajj
    Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut 1107 2020, Lebanon
    J Exp Med 207:2785-92. 2010
    ..Our demonstration that this drug combination targeting Tax stability abrogates tumor cell immortality but not short-term growth may foretell a favorable long-term efficiency of this regimen in patients...
  46. ncbi Optimal cytocompatibility of a bioceramic nanoparticulate cement in primary human mesenchymal cells
    Gustavo De-Deus
    Department of Endodontics, Veiga de Almeida University, Rio de Janeiro, Brazil
    J Endod 35:1387-90. 2009
    ..White Pro-Root MTA (Dentsply, Tulsa Dental, Tulsa, OK) was used as a reference for comparison...
  47. pmc Retinoic acid (RA) and As2O3 treatment in transgenic models of acute promyelocytic leukemia (APL) unravel the distinct nature of the leukemogenic process induced by the PML-RARalpha and PLZF-RARalpha oncoproteins
    E M Rego
    Department of Human Genetics, Molecular Biology Program, and Department of Medicine, Molecular Therapeutics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 97:10173-8. 2000
    ....
  48. ncbi Cell tagging with clinically approved iron oxides: feasibility and effect of lipofection, particle size, and surface coating on labeling efficiency
    Lars Matuszewski
    Department of Clinical Radiology, University Hospital Muenster, Albert Schweitzer Strasse 33, D 48129 Muenster, Germany
    Radiology 235:155-61. 2005
    To evaluate the effect of lipofection, particle size, and surface coating on labeling efficiency of mammalian cells with superparamagnetic iron oxides (SPIOs).
  49. ncbi Effects of mineral trioxide aggregate on cell survival, gene expression associated with mineralized tissues, and biomineralization of cementoblasts
    Sema S Hakki
    Faculty of Dentistry, Department of Periodontology, Selcuk University, Konya, Turkey
    J Endod 35:513-9. 2009
    ..02 and 0.002 mg/mL. Based on these results MTA can be considered as a favorable material regarding cell-material interaction...
  50. ncbi Apexification: a review
    Mary Rafter
    University of Michigan School of Dentistry, Ann Arbor, MI 48109 1078, USA
    Dent Traumatol 21:1-8. 2005
    ..Success rates for calcium hydroxide apexification are high although risks such as reinfection and tooth fracture exist. Prospective clinical trials comparing this and one-visit apexification techniques are required...
  51. ncbi Arsenic trioxide induces selective tumour vascular damage via oxidative stress and increases thermosensitivity of tumours
    R J Griffin
    Department of Therapeutic Radiology Radiation Oncology, University of Minnesota Medical School, 420 Delaware St S E, MMC 494, Minneapolis, MN 55455, USA
    Int J Hyperthermia 19:575-89. 2003
    ....
  52. pmc Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia
    Jiong Hu
    State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine and Institute of Health Science, Chinese Academy of Sciences, Shanghai 200025, China
    Proc Natl Acad Sci U S A 106:3342-7. 2009
    ..These results demonstrate the high efficacy and minimal toxicity of ATRA/ATO treatment for newly diagnosed APL in long-term follow-up, suggesting a potential frontline therapy for de novo APL...
  53. pmc All-trans retinoic acid/As2O3 combination yields a high quality remission and survival in newly diagnosed acute promyelocytic leukemia
    Zhi Xiang Shen
    Shanghai Institute of Hematology, State Key Lab of Medical Genomics, Rui Jin Hospital, Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China
    Proc Natl Acad Sci U S A 101:5328-35. 2004
    ..In conclusion, the ATRA/As(2)O(3) combination for remission/maintenance therapy of APL brings much better results than either of the two drugs used alone in terms of the quality of CR and the status of the disease-free survival...
  54. ncbi Nanosheets of oxides and hydroxides: Ultimate 2D charge-bearing functional crystallites
    Renzhi Ma
    International Center for Materials Nanoarchitectonics, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Adv Mater 22:5082-104. 2010
    A wide variety of cation-exchangeable layered transition metal oxides and their relatively rare counterparts, anion-exchangeable layered hydroxides, have been exfoliated into individual host layers, i.e., nanosheets...
  55. ncbi Reduction of graphene oxide via bacterial respiration
    Everett C Salas
    Department of Earth Science, Rice University, 6100 Main Street, Houston, Texas 77005, USA
    ACS Nano 4:4852-6. 2010
    ..This capability also provides an opportunity for further investigation into the application of environmental bacteria in the area of green nanochemistries...
  56. ncbi Role of indoxyl sulfate in the progression of chronic kidney disease and cardiovascular disease: experimental and clinical effects of oral sorbent AST-120
    Toshimitsu Niwa
    Department of Advanced Medicine for Uremia, Nagoya University School of Medicine, Nagoya, Japan
    Ther Apher Dial 15:120-4. 2011
    ..Experimental and clinical data demonstrate that AST-120 delays the progression not only of chronic kidney disease, but also of cardiovascular disease...
  57. ncbi Phosphorylation of PML by mitogen-activated protein kinases plays a key role in arsenic trioxide-mediated apoptosis
    Fumihiko Hayakawa
    Section of Microbiology, Division of Biological Sciences, University of California at Davis, Davis, CA 95616, USA
    Cancer Cell 5:389-401. 2004
    ..We conclude that phosphorylation by MAP kinase cascades potentiates the antiproliferative functions of PML and helps mediate the proapoptotic effects of As(2)O(3)...
  58. ncbi Graphene oxide, highly reduced graphene oxide, and graphene: versatile building blocks for carbon-based materials
    Owen C Compton
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA
    Small 6:711-23. 2010
    ..The excellent mechanical and electronic properties of the resulting materials are highlighted with a forward outlook on their applications...
  59. ncbi The sealing ability and retention characteristics of mineral trioxide aggregate in a model of apexification
    Darlene R Hachmeister
    Department of Endodontics, University of Texas Health Science Center at San Antonio, 78229 3900, USA
    J Endod 28:386-90. 2002
    ..MTA shows promise in our proposed treatment option of immature pulpless teeth if the sealing ability can be enhanced by improving the delivery technique...
  60. pmc Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination
    J W Bulte
    Laboratory of Diagnostic Radiology Research Clinical Center, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 96:15256-61. 1999
    ....
  61. ncbi Treatment of tooth discoloration after the use of white mineral trioxide aggregate
    Ilya Belobrov
    Melbourne Dental School, University of Melbourne, Melbourne, Australia
    J Endod 37:1017-20. 2011
    ..This case report describes the treatment of tooth discoloration caused by white MTA (WMTA) used for the management of a complicated crown fracture...
  62. ncbi An environment-friendly preparation of reduced graphene oxide nanosheets via amino acid
    Dezhi Chen
    School of Chemistry and Environment, Beijing University of Aeronautics and Astronautics, Beijing 100191, People s Republic of China School of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, People s Republic of China
    Nanotechnology 22:325601. 2011
    ....
  63. ncbi NiO and Co3O4 nanoparticles induce lung DTH-like responses and alveolar lipoproteinosis
    W S Cho
    ELEGI Colt Laboratory, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK
    Eur Respir J 39:546-57. 2012
    ..These findings have implications for the risk management of occupational NP exposure and provide evidence that haptenic metal oxide NPs can induce chronic progressive lung immune responses via a DTH-like mechanism...
  64. ncbi Photocatalytic reduction of carbon dioxide over Ag cocatalyst-loaded ALa4Ti4O15 (A = Ca, Sr, and Ba) using water as a reducing reagent
    Kosuke Iizuka
    Department of Applied Chemistry, Faculty of Science, Research Institute of Science and Technology, Tokyo University of Science, 1 3 Kagurazaka, Tokyo 162 8601, Japan
    J Am Chem Soc 133:20863-8. 2011
    ..Thus, an uphill reaction of CO(2) reduction accompanied with water oxidation was achieved using the Ag/BaLa(4)Ti(4)O(15) photocatalyst...
  65. ncbi Changes in the surface of four calcium silicate-containing endodontic materials and an epoxy resin-based sealer after a solubility test
    R P Borges
    Department of Endodontics, University of Ribeirao Preto, Ribeirao Preto, Sao Paulo, Brazil
    Int Endod J 45:419-28. 2012
    ....
  66. ncbi Characterization and analyses of acid-extractable and leached trace elements in dental cements
    J Camilleri
    Department of Restorative Dentistry, Faculty of Dental Surgery, University of Malta, Msida, Malta
    Int Endod J 45:737-43. 2012
    ..Determination of the elemental constitution and investigation of the total and leachable arsenic, chromium and lead in Portland cement, pure tricalcium silicate, Biodentine, Bioaggregate and mineral trioxide aggregate (MTA) Angelus...
  67. ncbi Mineral trioxide aggregate: a review of the constituents and biological properties of the material
    J Camilleri
    Department of Conservative Dentistry, Dental Institute, King s College London, London, UK
    Int Endod J 39:747-54. 2006
    ..Relatively few articles addressed the constituents of MTA, whilst cytological evaluation was the most widely used biocompatibility test...
  68. ncbi Oxygen reduction electrocatalyst based on strongly coupled cobalt oxide nanocrystals and carbon nanotubes
    Yongye Liang
    Department of Chemistry, Stanford University, Stanford, California 94305, United States
    J Am Chem Soc 134:15849-57. 2012
    ....
  69. ncbi Proteins involved in electron transfer to Fe(III) and Mn(IV) oxides by Geobacter sulfurreducens and Geobacter uraniireducens
    M Aklujkar
    Department of Microbiology, University of Massachusetts Amherst, Amherst, MA 01003, USA
    Microbiology 159:515-35. 2013
    ..Other electron transport genes upregulated on both metal oxides included genes encoding putative menaquinol : ferricytochrome c oxidoreductase complexes Cbc4 and Cbc5, ..
  70. ncbi The immunotoxicity of graphene oxides and the effect of PVP-coating
    Xiao Zhi
    Department of Bio Nano Science and Engineering, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Institute of Micro Nano Science and Technology, Shanghai Jiao Tong University, Shanghai 200240, People s Republic China
    Biomaterials 34:5254-61. 2013
    ..In conclusion, PVP-coating GO possesses good immunological biocompatibility and immunoenhancement effects in vitro, and is likely to be an available candidate of immunoadjuvant in the future...
  71. ncbi How I treat adult T-cell leukemia/lymphoma
    Ali Bazarbachi
    Department of Internal Medicine, American University of Beirut, Beirut, Lebanon
    Blood 118:1736-45. 2011
    ..To prevent relapse, clinical trials assessing consolidative targeted therapies such as arsenic/IFN combination or novel monoclonal antibodies are needed. Finally, allogeneic BM transplantation should be considered in suitable patients...
  72. ncbi Facile synthesis of soluble graphene via a green reduction of graphene oxide in tea solution and its biocomposites
    Yan Wang
    School of Chemistry and Chemical Technology, State Key Laboratory of Metal Matrix Composite Materials, Shanghai Jiao Tong University, 200240 Shanghai, PR China
    ACS Appl Mater Interfaces 3:1127-33. 2011
    ..These features endow this green approach with great potential in constructing of various graphene-based materials, especially for high-performance biorelated materials as demonstrated in this study of chitosan/graphene composites...
  73. ncbi Effect of acidic environment on the push-out bond strength of mineral trioxide aggregate
    Noushin Shokouhinejad
    Department of Endodontics, Faculty of Dentistry Dental Research Center, Tehran University of Medical Sciences, Tehran, Iran
    J Endod 36:871-4. 2010
    ..In this study, the effect of an acidic environment on the push-out strength of MTA was evaluated...
  74. ncbi Analyses of heavy metals in mineral trioxide aggregate and Portland cement
    Matthew Schembri
    Department of Chemistry, University of Malta, Msida, Malta
    J Endod 36:1210-5. 2010
    ..Heavy metal inclusion can be of concern because MTA is in contact with hard and soft tissues...
  75. ncbi An environmentally friendly approach to the reduction of graphene oxide by Escherichia fergusoni
    Sangiliyandi Gurunathan
    Department of Animal Biotechnology, Konkuk University, 1 Hwayang dong, Gwangin gu, Seoul 143 701, Korea
    J Nanosci Nanotechnol 13:2091-8. 2013
    ..Raman spectroscopy images provide clear evidence for the formation of graphene. All these findings clearly indicate that GO could be reduced by simple, eco-friendly method by using E. fergusoni to produce water dispersible graphene...
  76. ncbi High yield preparation of macroscopic graphene oxide membranes
    Zhengtang Luo
    Department of Physics and Astronomy, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Am Chem Soc 131:898-9. 2009
    ..Field effect transistors made of the membrane show ambipolar behavior, and their conductivity is significantly higher than previously reported values...
  77. ncbi Metal oxide hollow nanostructures for lithium-ion batteries
    Zhiyu Wang
    School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore
    Adv Mater 24:1903-11. 2012
    ..By focusing on hollow structures of some binary metal oxides (such as SnO 2 ,TiO 2 , Fe 2 O 3 , Co 3 O 4 ) and complex metal oxides, we seek to provide some rational ..
  78. ncbi Bacteriogenic manganese oxides
    Thomas G Spiro
    Department of Chemistry, University of Washington, Seattle, Washington 98195, USA
    Acc Chem Res 43:2-9. 2010
    ..Diverse bacteria and fungi have evolved the ability to catalyze this process, producing the manganese oxides found in soils and sediments...
  79. ncbi Engineered cobalt oxide nanoparticles readily enter cells
    Elena Papis
    Department of Biotechnology and Molecular Science, Insubria University, Varese, Italy
    Toxicol Lett 189:253-9. 2009
    ..Interestingly, Co3O4-NPs are able to enter the cell very rapidly, remaining confined in vesicles inside the cytoplasm. They were found also inside the cell nuclei, though less frequently...
  80. ncbi Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles
    Kai Yang
    Jiangsu Key Laboratory for Carbon Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu, China
    Adv Mater 24:1868-72. 2012
    ....
  81. ncbi Formation of ZnMn2O4 ball-in-ball hollow microspheres as a high-performance anode for lithium-ion batteries
    Genqiang Zhang
    TUM CREATE Centre for Electromobility, Singapore
    Adv Mater 24:4609-13. 2012
    ....
  82. ncbi How acute promyelocytic leukaemia revived arsenic
    Jun Zhu
    CNRS UPR 9051, Laboratoire associé du comité de Paris de la ligue contre le cancer, affilié à l Université de Paris VII, Hopital St Louis, 1 avenue C Vellefaux, 75475 Paris Cedex 10, France
    Nat Rev Cancer 2:705-13. 2002
    ....
  83. ncbi Repair of furcal perforation using a new endodontic cement
    Mohammad Samiee
    Dental School, Tabriz University of Medical Sciences, Tabriz, Iran
    Clin Oral Investig 14:653-8. 2010
    ..MTA and CEM cement showed similar favorable biological response in furcation perforation repair, especially in inducing the formation of cementum-like hard tissue...
  84. ncbi The overexpression of multidrug resistance-associated proteins and gankyrin contribute to arsenic trioxide resistance in liver and gastric cancer cells
    Xi Chen
    General Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, P R China
    Oncol Rep 22:73-80. 2009
    ..These two arsenic-resistant solid tumor cell lines, HepG2/AS and SGC7901/AS, may be useful for studying the mechanism of arsenic resistance in solid tumors and may provide a way to overcome it...
  85. ncbi Comparative study of white and gray mineral trioxide aggregate (MTA) simulating a one- or two-step apical barrier technique
    Gary D Matt
    Naval Postgraduate Dental School, Bethesda, MD, USA
    J Endod 30:876-9. 2004
    ..01). Results suggested that a 5 mm apical barrier of gray MTA, using two-steps, provided the best apical barrier...
  86. pmc Reactive oxygen species are not required for an arsenic trioxide-induced antioxidant response or apoptosis
    Alejo A Morales
    Department of Microbiology and Immunology and the Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    J Biol Chem 284:12886-95. 2009
    ..Moreover, silencing Nrf2 had no effect on ATO-induced apoptosis. Together these data suggest that ROS is not important in the induction of the antioxidative response or cellular death by ATO...
  87. ncbi Microbial toxicity of metal oxide nanoparticles (CuO, NiO, ZnO, and Sb2O3) to Escherichia coli, Bacillus subtilis, and Streptococcus aureus
    Yong Wook Baek
    Department of Environmental Science, Konkuk University, 1 Hwayang dong, Gwangjin gu, Seoul 143 701, Republic of Korea
    Sci Total Environ 409:1603-8. 2011
    ....
  88. ncbi Transparent, flexible, all-reduced graphene oxide thin film transistors
    Qiyuan He
    School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore
    ACS Nano 5:5038-44. 2011
    ..The specific detection of avidin by using biotinylated all-rGO sensor is also successfully demonstrated...
  89. ncbi All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4)
    Harry J Iland
    Royal Prince Alfred Hospital, Camperdown, Australia
    Blood 120:1570-80; quiz 1752. 2012
    ..This trial was registered at the Australian New Zealand Clinical Trials Registry (www.anzctr.org.au) as ACTRN12605000070639...
  90. ncbi Tuning the mechanical properties of graphene oxide paper and its associated polymer nanocomposites by controlling cooperative intersheet hydrogen bonding
    Owen C Compton
    Department of Chemistry, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, USA
    ACS Nano 6:2008-19. 2012
    ....
  91. ncbi The use of MTA in teeth with necrotic pulps and open apices
    Valentina Giuliani
    Department of Endodontics, The University of Florence, Italy
    Dent Traumatol 18:217-21. 2002
    ..MTA appears to be a valid option for apexification with its main advantage being the speed at which the treatment can be completed...
  92. ncbi Arsenic trioxide treatment decreases the oxygen consumption rate of tumor cells and radiosensitizes solid tumors
    Caroline Diepart
    Biomedical Magnetic Resonance Group, Louvain Research Institute, Universite Catholique de Louvain, Brussels, Belgium
    Cancer Res 72:482-90. 2012
    ..Together, our findings show that As(2)O(3) acutely increases oxygen consumption and radiosensitizes tumors, providing a new rationale for clinical investigations of As(2)O(3) in irradiation protocols to treat solid tumors...
  93. ncbi Contribution of physicochemical characteristics of nano-oxides to cytotoxicity
    Mingsheng Xu
    International Center for Young Scientists, National Institute for Materials Science, Tsukuba, Ibaraki, Japan
    Biomaterials 31:8022-31. 2010
    To identify the key physicochemical properties of nano-oxides governing cytotoxicity, we investigate the contribution of the size, shape, morphology, and electronic properties of ten types of insulator (SiO(2), CeO(2) and Al(2)O(3)) and ..
  94. ncbi Long-term effects of the oral adsorbent, AST-120, in patients with chronic renal failure
    K Maeda
    Division of Nephrology, Department of Internal Medicine, Juntendo University Nerima Hospital, Tokyo, Japan
    J Int Med Res 37:205-13. 2009
    ..The results suggest that long-term treatment with AST-120 may be beneficial for chronic renal failure patients in the pre-dialysis stage...
  95. pmc Arsenic trioxide inhibits human cancer cell growth and tumor development in mice by blocking Hedgehog/GLI pathway
    Elspeth M Beauchamp
    Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC, USA
    J Clin Invest 121:148-60. 2011
    ..These results warrant the clinical investigation of ATO for tumors with activated Hh/GLI signaling, in particular patients who develop resistance to current therapies targeting the Hh pathway upstream of GLI...
  96. ncbi Phase II study of single-agent arsenic trioxide for the front-line therapy of acute promyelocytic leukemia
    Ardeshir Ghavamzadeh
    Hematology, Oncology, and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Kargar Ave, Tehran, Iran
    J Clin Oncol 29:2753-7. 2011
    ..Several studies have shown high efficacy of single-agent arsenic trioxide in newly diagnosed APL. However, long-term follow-up results are needed...
  97. ncbi Poly(L-lysine)-modified iron oxide nanoparticles for stem cell labeling
    Michal Babic
    Institute of Macromolecular Chemistry, v v i, Academy of Sciences of the Czech Republic, Heyrovsky Sq 2, 162 06 Prague 6, Czech Republic
    Bioconjug Chem 19:740-50. 2008
    ..In comparison with Endorem, nanoparticles modified with PLL of an optimum molecular weight demonstrated a higher efficiency of intracellular uptake by MSC cells...
  98. ncbi Instant MR labeling of stem cells using magnetoelectroporation
    P Walczak
    Russell H Morgan Department of Radiology and Radiological Science, MR Research Division, and Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Magn Reson Med 54:769-74. 2005
    ..As MEP circumvents the use of secondary agents, obviating the need for clinical approval, MEP labeling may be ideally suitable for bedside implementation...
  99. ncbi Involvement and specificity of Shewanella oneidensis outer membrane cytochromes in the reduction of soluble and solid-phase terminal electron acceptors
    Clemens Bücking
    Department of Microbiology, Institute for Biology II, University of Freiburg, Germany
    FEMS Microbiol Lett 306:144-51. 2010
    ..the surface of the cell that establishes the connection to insoluble electron acceptors such as iron or manganese oxides. The gammaproteobacterium Shewanella oneidensis MR-1 contains the genetic information for five putative OM ..
  100. pmc Metal oxide nanoparticles induce unique inflammatory footprints in the lung: important implications for nanoparticle testing
    Wan Seob Cho
    ELEGI The Edinburgh Lung and the Environment Group Initiative, Centre for Inflammation Research, University of Edinburgh, Edinburgh, United Kingdom
    Environ Health Perspect 118:1699-706. 2010
    ..Metal oxide nanoparticles (NPs) have been widely used in industry, cosmetics, and biomedicine...
  101. pmc A novel nanoparticulate formulation of arsenic trioxide with enhanced therapeutic efficacy in a murine model of breast cancer
    Richard W Ahn
    Department of Chemistry, Chemistry of Life Processes Institute, Evanston, Illinois 60208, USA
    Clin Cancer Res 16:3607-17. 2010
    ..We postulated that nanobin encapsulation of As(2)O(3) would improve its therapeutic index against clinically aggressive solid tumors, such as triple-negative breast carcinomas...

Research Grants63

  1. Characterizing TiO2 as an Anti-Inflammatory Biomaterial
    John Frangos; Fiscal Year: 2005
    ..Different forms of surface oxide can exist on titanium, and the relationship between defined surface oxides and anti-inflammatory response will be determined...
  2. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..Vitamin E, in particular the gamma-tocopherol isoform, has been shown to preferentially scavenge higher oxides. Previously we've studied the effect of scavenging reactive oxygen and nitrogen species, via tocopherol ..
  3. Traffic-Related Air Pollution and Ultrasound Measures of Fetal Growth
    MICHELLE WILHELM TURNER; Fiscal Year: 2010
    ..This hypothesis will be addressed by: (1) estimating prenatal exposures to nitrogen oxides (NOx) - as a marker of traffic-related air pollutants - for BIPS participants using CALINE4 air dispersion ..
  4. Redox Determinants of Severe Asthma
    Serpil C Erzurum; Fiscal Year: 2010
    ..In aim 3, we investigate formation of cytotoxic nitrogen oxides and loss of beneficial nitrogen oxides...
  5. Defining target specificity of oxadiazole 2-oxides in Ancylostoma ceylanicum
    Jon J Vermeire; Fiscal Year: 2012
    ..Project: 1K22AI089969-01 Title: Defining target specificity of oxadiazole 2-oxides in Ancylostoma ceylanicum Accession Number: 3233568 ================== NOTICE: THIS ABSTRACT WAS EXTRACTED FROM ..
  6. Myoglobin as a Nitrite Reductase that Regulates Hypoxic Cardiac NO Signaling
    Sruti Shiva; Fiscal Year: 2013
    ..suggesting that myoglobin, the other major heme globin, may also possess a capability to mediate the metabolism of oxides of nitrogen in a manner influenced by oxygen tension...
  7. BIOINORGANIC COPPER COORDINATION CHEMISTRY
    Kenneth D Karlin; Fiscal Year: 2013
    ..coordination chemistry relevant to its essential role in the biochemical processing of dioxygen (O2) and nitrogen oxides (NOx)...
  8. Novel targets and drugs for the control of platyhelminth infections
    MARCOS GUSTAVO SALINAS; Fiscal Year: 2012
    ..Recent studies in schistosomiasis validated TGR as a novel rational drug target, and have shown that oxadiazole N-oxides offer great promise as new drug leads for schistosomiasis...
  9. Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Rheal A Towner; Fiscal Year: 2010
    ..IO nanoprobes, such as ultrasmall superparamagnetic iron oxides (USPIOs) have recently become popular as molecular reporting probes with the use of molecular magnetic resonance ..
  10. 2010 Oxygen Radicals: Mechanisms that Underpin Redox Biology - a Gordon Research
    Garry R Buettner; Fiscal Year: 2010
    ..stress;oxidative events in cardiovascular disease;biochemistry of thiol oxidation &thiol enzymes;nitrogen oxides &hydrogen sulfide;protein oxidation, redox changes &aging;mitochondria, central to redox balance;..
  11. Air Pollution and Children's Cognitive and Health Outcomes
    Ashlesha Datar; Fiscal Year: 2013
    ..has linked exposure to criteria pollutants (particulate matter, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead) with adverse health outcomes in children, however, much of this literature is based on ..
  12. Cellular S-nitrosothiol signaling in respiratory biology
    Lisa Palmer; Fiscal Year: 2013
    ..Emerging evidence from our group and others suggests that S-nitrosothiol (and related nitrogen oxides such as nitrite)-based signaling downstream from nitric oxide synthase activation is relevant to respiratory ..
  13. Air pollution exposure and COPD in the Framingham Heart Study
    Mary B Rice; Fiscal Year: 2013
    ..that elevations in short-term exposure to air pollutants (fine particulate matter, black carbon, ozone, nitrogen oxides, sulfates and metals) will impair lung function by spirometry and DLCO after adjustment for smoking...
  14. Air Pollution and Parkinson's in the Danish PASIDA Study
    Beate R Ritz; Fiscal Year: 2013
    ..Exposure is modeled in AirGIS based on nitrogen dioxides (NO2)/nitrogen oxides (NOx) which serve as indicators for air pollution mixtures from traffic...
  15. PHYSIOLOGY OF FLUOROCARBON OXYGEN TRANSPORT
    LELAND CLARK; Fiscal Year: 1992
    ..by preparative gas chromatography and with various emulsifiers including Pluronic F68, polyfluorinated amine oxides, egg lecithins, and other surfactants. Fluorocarbons will include F- decalin, F-tributylamine, and F-phenanthrene...
  16. Interactions of engineered nanomaterials with lung alveolar epithelium
    EDWARD DAVID CRANDALL; Fiscal Year: 2010
    ..Based on our ongoing research on lung injury and trafficking of several (e.g., polystyrene, silica and metal (oxides)) classes of nanoparticles with defined physicochemical characteristics, and recent reports on health effects of ..
  17. Exposure to Traffic-Related Air Pollution and to Disability in Older Adults
    Jennifer Weuve; Fiscal Year: 2013
    ..highways, truck routes and bus routes, along with the traffic count data) and exposure to oxides of nitrogen (NOx), a major component of vehicle emissions...
  18. Improved Batteries for Implantable Cardiac Defibrillators
    Kenneth J Takeuchi; Fiscal Year: 2012
    ..1) develop a new class of improved battery materials for ICD applications based on metal-metal-phosphorous-oxides of the MwM'xPyOz (MM'PO) family (M = silver or copper;M'= vanadium or iron), 2) test the materials ..
  19. Photodegradation Reactions Mono and Dinitro PAHs
    Rafael Arce; Fiscal Year: 2011
    ..principal stable photoproducts produced on adsorbents that mimic the atmospheric particle matter such as inorganic oxides, and sulfate salts, and determine the effect of the physical and chemical properties of the surfaces of these ..
  20. Nanoparticle properties and alveolar epithelial barrier/transport functions
    EDWARD DAVID CRANDALL; Fiscal Year: 2013
    ..on lung injury/uptake/trafficking of several classes of nanoparticles (composed of polystyrene, silica and metal (oxides)) with defined physicochemical characteristics and recent reports on health effects of inhaled ultrafine air ..
  21. Redox Transduction of Nitric Oxide Signaling
    BRUCE ALAN FREEMAN; Fiscal Year: 2013
    Nitric oxide (NO) mediates cell signaling via cGMP- and non-cGMP-dependent reactions and yields secondary oxides of nitrogen (NOx) that expand the range of molecular targets of NO via oxidation, nitrosation and nitration reactions...
  22. Reagents to Enhance Detection of Raw and Biologically Transformed Nanomaterials
    Lisa A Delouise; Fiscal Year: 2012
    ..Nanomaterials of interest include carbon nanotubes, metal oxides, metals, and semiconductors...
  23. Nanoparticle exposure assessment during chemical mechanical planarization operati
    Sara Brenner; Fiscal Year: 2013
    ..This pilot study will focus specifically on occupational exposures to nanoparticle metal oxides and metalloids utilized in the "chemical-mechanical planarization" (CMP) process in semiconductor wafer production...
  24. Novel Mechanism of Uranium Reduction Via Microbial Nanowires
    Gemma Reguera; Fiscal Year: 2011
    ..of U(VI) and other soluble contaminants by these microorganisms is directly dependent on the reduction of Fe(III) oxides, their natural electron acceptor...
  25. From Nanoparticles to Novel Protective Garments
    Shyamala Rajagopalan; Fiscal Year: 2009
    ..As a result, this Phase II project will begin by developing methodologies for granulation of mixed metal oxides based on NanoActive materials...
  26. Electrodeposited Noble Metal Oxide Neural Electrodes
    Stuart Cogan; Fiscal Year: 2002
    The development of electrodeposited noble metal oxides as low-impedance, high-charge injection coatings for neural recording and stimulating electrodes is proposed. The coatings are based on iridium and ruthenium oxides...
  27. Predictive Toxicological Paradigm for Chronic Nanoparticle Injury in the Lung
    ANDRE ELIAS NEL; Fiscal Year: 2013
    ..This scenario will be compared against acute lung injury by transition metal oxides. Aim 2: To develop a predictive toxicological paradigm that relates the framework chemistry and hydration status ..
  28. PEROXIDASE IN SALIVA AND PREVENTION OF ORAL DISEASE
    EDWIN THOMAS; Fiscal Year: 1992
    ..The third aim is to investigate the role of nitrite and reactive nitrogen-oxides in oral microbial ecology and examine their interactions with the LP system...
  29. Inorganic Nanoparticles in Non-Polymeric Organic Coating for Biomedical Applicati
    GALINA Z GOLOVERDA; Fiscal Year: 2012
    ..Colloidal alumina will be used along with superparamagnetic iron oxides for the development of organic ligand synthesis which will decrease the possibility of undesired oxidation and ..
  30. Methods to Assess Personal Exposures to Airborne Metallic Nanoparticles
    THOMAS MICHAEL PETERS; Fiscal Year: 2011
    ..can elicit adverse cardiopulmonary health outcomes and their toxicity, particularly for metals and metal oxides, can be substantially greater than that of larger particles of the same composition...
  31. A Transcutaneous Gas Sensor for Noninvasive Diagnosis of Necrotizing Enterocoliti
    OOMMAN VARGHESE; Fiscal Year: 2009
    ..We propose to develop a noninvasive, room-temperature transcutaneous gas sensor based on the nano-structured metal oxides as a rapid medical diagnostic...
  32. IN SITU ANALYSIS OF HUMAN PLAQUE FORMATION
    Greg Germaine; Fiscal Year: 1991
    ..with transition elements via chelate conjugates and (ii) labeling with sized colloidal gold, silver and metal oxides. In situ grown plaque specimens will be recovered and reacted directly (initial or early plaque) or sectioned (..
  33. Multi-Parameter Monitoring of Breast Cancer Progression and Therapeutic Response
    Anna Moore; Fiscal Year: 2011
    ..If successful, this study can further be translated into clinical applications, since related iron oxides have already been tested in clinical trials.
  34. Nitrogen Oxides and Heme
    GEORGE RICHTER ADDO; Fiscal Year: 2007
    Iron plays significant roles in the chemistry of nitrogen oxides in the biosphere...
  35. Dosimetry of Lipid-Derived Amino Acid Adducts by LC/MS
    Ian Blair; Fiscal Year: 2006
    ..This paradox arises from the observation that infusions of L-arginine can cause additional nitric oxides release even though there is apparently sufficient free intracellular arginine to saturate endogenous nitric oxide ..
  36. PYRIDINE--ENZYME INDUCTION, METABOLISM, AND TOXICITY
    Melissa Runge Morris; Fiscal Year: 1991
    ..of pyridine to an N-oxide derivative is an important biotransformation pathway in vivo, and some nitrogen oxides have implicated as carcinogens...
  37. Dental Cast Titanium-Ceramic Bonding
    Zhuo Cai; Fiscal Year: 2003
    ..underlying the investigation is that the surface reaction structure can be minimized by face-coating patterns with oxides that are more stable than titanium oxides at temperatures near titanium solidification...
  38. SBIR Topic 241 Phase II: Platelet-based Nanoparticle Therapy for Prostate Cancer
    Michael Zwick; Fiscal Year: 2010
    ..We propose to further validate the use of human platelet products loaded with iron oxides as delivery vehicles for imaging and therapeutic modalities;to use phage display technology to enhance the ..
  39. Enantioselective Catalysis with Cyclopropenimines
    Tristan H Lambert; Fiscal Year: 2013
    ..grant are: enantioselective glycine Mannich and ?-thio Mannich reactions;?-arylations with quinones and benzene oxides;Michael additions with low acidity nucleophiles, including diazoesters;allylic alkylations;and enantioselective ..
  40. Xanthine DNA Glycosylase in Mammalian Systems
    Weiguo Cao; Fiscal Year: 2010
    ..Nitrogen oxides (NOx) in the environment or RNS produced from endogenous sources can cause deamination in DNA bases...
  41. Novel Platform for NOx Reduction from Furnaces
    DONALD STOOKEY; Fiscal Year: 2004
    b>Oxides of nitrogen are well-known environmental pollutants. They have been the subjects of extensive regulations including the Clean Air Act...
  42. GLUTATHIONE PATHWAY TO THE FORMATION OF PHENOLS
    KHINGKAN LERTRATANANGKOON; Fiscal Year: 1992
    ..may be the major mode of phenol formation for many aromatic compounds whose metabolism involve the reaction of oxides with glutathione. This pathway may be responsible for bromobenzene toxicity in high dosage...
  43. NITROGEN OXIDE (NOX) REDOX CHEMISTRY WITH COPPER ION
    KENNETH KARLIN; Fiscal Year: 1993
    Chemical transformations involving the oxides of nitrogen (NOx) and sulfur (SOx) are of considerable environmental and biological importance. Industrial and other combustion (e.g...
  44. Throughmask ElectroEtching for Cost-Effective Nitinol Stent Fabrication
    ALONSO LOZANO MORALES; Fiscal Year: 2010
    ..Process will not impart thermal damage to the stent, eliminating the need for descaling of undesired oxides. It is believed that the Faradayic Process will be able to "cut" a stent in less than two minutes, independent of ..
  45. Separation of Sr-90 and Ca2+ in Environmental Samples
    TERESIA MOLLER; Fiscal Year: 2004
    ..business innovation research Phase I project will utilize the controllable ion exchange properties of mixed metal oxides to efficiently separate radiostrontium from calcium (and other alkaline earth metals)...
  46. SULFUR OXIDES EFFECTS ON LUNG FUNCTION IN ASTHMATICS
    Jane Koenig; Fiscal Year: 1991
    ..This research will provide important data on the health effects of air pollution which will help establish a scientific base for setting national ambient air quality standards...
  47. DIETARY INTERVENTION--WOMEN HIGH RISK FOR BREAST CANCER
    Zora Djuric; Fiscal Year: 2002
    ..in the proposed clinical trial, the applicant plans to measure the levels of oxidative DNA damage and cholesterol oxides. These intermediate biomarkers are indicative of oxidative stress levels, and oxidative stress has been associated ..
  48. REGULATION OF RYANODINE RECEPTOR BY NITROGEN OXIDES
    Jerry Eu; Fiscal Year: 2003
    ..Our results may lead to new insights into regulation of Ca2+ homeostasis in muscle and to the dysregulation of Ca2+ characteristic of disease states such as respiratory failure and rhabdomyolysis. ..
  49. PROTEIN MODIFICATION BY NITRATION IN AGING RATS
    Reiko Matsui; Fiscal Year: 2001
    ..Peroxynitrite and other reactive nitrogen oxides nitrate proteins and modify their function...
  50. REACTIVITY OF NICKEL COMPLEXES WITH DNA
    CYNTHIA BURROWS; Fiscal Year: 1999
    DESCRIPTION: Human exposure to toxic metals including nickel and toxic oxides including SO(x) and NO(x) results in damage to genetic material...
  51. Nanoparticles for Filtration of TICs
    SLAWOMIR WINECKI; Fiscal Year: 2003
    The proposed work is focused on the development of a novel air filtration media utilizing nanoparticle metal oxides. The system will be capable of purifying air from a broad range of toxic industrial chemicals that do not effectively ..
  52. Anti-Inflamatory Coatings for Biomaterials
    John Frangos; Fiscal Year: 2006
    ..Project 1 will investigate the basic mechanisms of action of metal oxides in the catalytic breakdown of reactive oxygen species...
  53. INACTIVATION, STRUCTURE, AND MECHANISM OF MAO
    Richard Silverman; Fiscal Year: 2002
    ..Mechanistic information will be obtained with the use of pyridine N-oxides as potential intramolecular radical traps, and by investigating the possible involvement of an active site ..
  54. PHARMACOKINETICS OF REVERSIBLE METABOLIC SYSTEMS
    William Jusko; Fiscal Year: 1993
    ..Numerous compounds such as corticosteroids, estrogens, sulfonamides, N- oxides, sulfoxides, some acylglucuronide and disulfide conjugates, HMG- CoA reductase inhibitors, and many others have or ..
  55. ESTROGEN CARCINOGENICITY AND HORMONE-DEPENDENT TUMORS
    Jonathan Li; Fiscal Year: 1992
    ..plausible reactive intermediates which might be involved in neoplastic changes in hamster kidney are the arene oxides and o-quinones of the catechol pathway...
  56. MYCOBACTERIAL RESISTANCE TO REACTIVE NITROGEN/OXYGEN
    Carl Nathan; Fiscal Year: 2003
    ..Two of these are novel genes found only in Mtb: nitrogen oxides and oxygen intermediates resistance (NOXR)-1 and -3...
  57. Nanoplatelet Reinforced Smectic Glasses For Dental Restorants
    STEPHEN WELLINGHOFF; Fiscal Year: 2009
    ..Of special interest are compositions of high radio-opacity and low cost, such as ZrO2 and barium substituted oxides. Nanoplatelets of narrow size distribution will form workable, nematic and/or columnar phases with liquid ..
  58. A NOVEL INORGANIC ELECTRONIC NOSE
    ANUNCIA GONZALEZ MARTIN; Fiscal Year: 2000
    ..In this project, we propose a innovative approach to prepare arrays of sensors based on semiconducting metal oxides in which the limitations associated with the current electronic noses will be eliminated...
  59. Nucleic Acid Binding & Amplifications Matrices
    JEFFREY IVES; Fiscal Year: 2002
    ..This project will combine Xtrana's proprietary metal oxides with the self-assembled, nanofabrication technology of Sandia National Laboratory (SNL) to create microscale frits ..
  60. DINITROANILINE HERBICIDE METABOLISM & TOXICOLOGY
    JUDD NELSON; Fiscal Year: 1980
    ..metabolites of dinitroaniline herbicides, particularly the polar derivatives such as benzimidazoles and their N-oxides, dihydroxy-benzimidazolines, etc., for use as reference standards...
  61. [3+2] Cycloaddition Reactions of Imidometal Complexes
    NEAL YAKELIS; Fiscal Year: 2005
    1 ,3-Dipolar species such as nitrile oxides, nitrones, nitrile imines, diazoalkanes, nitrile ylides, and azomethine ylides have shown broad application in organic synthesis as reactive intermediates which undergo [3+2] cycloaddition ..
  62. CHIRAL SYNTHON: 1,2-OXAPHOSPHETANE 2-OXIDES
    ERIC DOLENCE; Fiscal Year: 2001
    ..monoesters, evaluation of ring closure conditions, stability determination of the series of 1 ,2-oxaphosphetane 2-oxides using variable temperature P31 NMR, and evaluation of the regioselectivity of ring opening by various nucleophiles ..
  63. OZONE CHEMISTRY AND CHEMICAL CARCINOGENESIS
    Robert Murray; Fiscal Year: 1999
    ..Our specific aims include studying basic ozone chemistry and the chemistry of the ozone-derived oxidants, carbonyl oxides and dioxiranes...