s nitroso n acetylpenicillamine

Summary

Summary: A sulfur-containing alkyl thionitrite that is one of the NITRIC OXIDE DONORS.

Top Publications

  1. pmc NO donors potentiate the beta-adrenergic stimulation of I(Ca,L) and the muscarinic activation of I(K,ACh) in rat cardiac myocytes
    Najah Abi-Gerges
    Laboratoire de Cardiologie Cellulaire et Moleculaire, INSERM U 446, Universite Paris Sud, Faculte de Pharmacie, F 92296 Chatenay Malabry, France
    J Physiol 540:411-24. 2002
  2. ncbi Immunostimulation of rat primary astrocytes decreases intracellular ATP level
    C Y Shin
    Department of Pharmacology, College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Kwanak-Gu, 151-742, Seoul, South Korea
    Brain Res 902:198-204. 2001
  3. ncbi Interaction of nitric oxide donors and ascorbic acid on D-[3H] aspartate efflux from rat striatal slices
    M Reiser
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Germany
    Neurochem Res 24:61-7. 1999
  4. ncbi Stimulation by nitric oxide of gastric acid secretion in bullfrog fundic mucosa in vitro
    S Kawauchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Japan
    J Physiol Pharmacol 52:93-105. 2001
  5. ncbi Arginine release from rat cerebellar astrocytes: autocrine roles for glutamate and nitric oxide?
    Joanna Segieth
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Neurosci Lett 372:262-5. 2004
  6. ncbi Carbon monoxide and nitric oxide: interacting messengers in muscarinic signaling to the brain's circadian clock
    L R Artinian
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    Exp Neurol 171:293-300. 2001
  7. ncbi Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats
    Wagner Luis Reis
    Laboratory of Neuroendocrinology, Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Exp Physiol 92:903-11. 2007
  8. ncbi Renal tissue NO and intrarenal haemodynamics during experimental variations of NO content in anaesthetised rats
    M Grzelec-Mojzesowicz
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 58:149-63. 2007
  9. pmc Angiotensin-(1-7)-induced plasticity changes in the lateral amygdala are mediated by COX-2 and NO
    Doris Albrecht
    Institute of Neurophysiology, Charité Universitätsklinikum Berlin, Berlin, Germany
    Learn Mem 14:177-84. 2007
  10. ncbi Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway
    F Rodriguez-Pacheco
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    J Neuroendocrinol 20:406-12. 2008

Detail Information

Publications231 found, 100 shown here

  1. pmc NO donors potentiate the beta-adrenergic stimulation of I(Ca,L) and the muscarinic activation of I(K,ACh) in rat cardiac myocytes
    Najah Abi-Gerges
    Laboratoire de Cardiologie Cellulaire et Moleculaire, INSERM U 446, Universite Paris Sud, Faculte de Pharmacie, F 92296 Chatenay Malabry, France
    J Physiol 540:411-24. 2002
    ..Although this action of NO seemed to occur at the level of G proteins, it appeared to require a component distinct from receptors, G proteins or their effectors...
  2. ncbi Immunostimulation of rat primary astrocytes decreases intracellular ATP level
    C Y Shin
    Department of Pharmacology, College of Pharmacy, Seoul National University, San 56-1, Shillim-dong, Kwanak-Gu, 151-742, Seoul, South Korea
    Brain Res 902:198-204. 2001
    ....
  3. ncbi Interaction of nitric oxide donors and ascorbic acid on D-[3H] aspartate efflux from rat striatal slices
    M Reiser
    Institute of Medical Neurobiology, Otto von Guericke University of Magdeburg, Germany
    Neurochem Res 24:61-7. 1999
    ..Ascorbate was shown to exert its effect primarily by influencing the decomposition of these nitric oxide donors rather than by a direct interaction of ascorbate with nitric monoxide on glutamate release...
  4. ncbi Stimulation by nitric oxide of gastric acid secretion in bullfrog fundic mucosa in vitro
    S Kawauchi
    Department of Pharmacology and Experimental Therapeutics, Kyoto Pharmaceutical University, Misasagi, Yamashina, Japan
    J Physiol Pharmacol 52:93-105. 2001
    ..In addition, it was speculated that the histamine releasing action of NO may be due to peroxynitrite produced by NO and superoxide radicals...
  5. ncbi Arginine release from rat cerebellar astrocytes: autocrine roles for glutamate and nitric oxide?
    Joanna Segieth
    Department of Pharmacology, The School of Pharmacy, 29 39 Brunswick Square, London WC1N 1AX, UK
    Neurosci Lett 372:262-5. 2004
    ..In addition, our data suggest that basal glutamate release is regulated to some extent by tonic NO synthesis in these cells...
  6. ncbi Carbon monoxide and nitric oxide: interacting messengers in muscarinic signaling to the brain's circadian clock
    L R Artinian
    Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA
    Exp Neurol 171:293-300. 2001
    ....
  7. ncbi Central nitric oxide blocks vasopressin, oxytocin and atrial natriuretic peptide release and antidiuretic and natriuretic responses induced by central angiotensin II in conscious rats
    Wagner Luis Reis
    Laboratory of Neuroendocrinology, Department of Physiology, School of Medicine of Ribeirao Preto, University of Sao Paulo, Brazil
    Exp Physiol 92:903-11. 2007
    ..Thus, the central nitrergic system can act to inhibit AVP, OT and ANP secretion and the antidiuretic and natriuretic effects in response to Ang II...
  8. ncbi Renal tissue NO and intrarenal haemodynamics during experimental variations of NO content in anaesthetised rats
    M Grzelec-Mojzesowicz
    Laboratory of Renal and Body Fluid Physiology, M Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    J Physiol Pharmacol 58:149-63. 2007
    ..Since inhibition of nNOS decreased medullary NO by 80% and MBF by 20% only, this isoform has probably minor role in the maintenance of medullary perfusion...
  9. pmc Angiotensin-(1-7)-induced plasticity changes in the lateral amygdala are mediated by COX-2 and NO
    Doris Albrecht
    Institute of Neurophysiology, Charité Universitätsklinikum Berlin, Berlin, Germany
    Learn Mem 14:177-84. 2007
    ..Moreover, COX-2 is involved in the mediation of angiotensin-(1-7) effects on LTP. Finally, it is recognized that there is a molecular cross-talk between COX-2 and NO that may regulate synaptic plasticity...
  10. ncbi Ghrelin induces growth hormone secretion via a nitric oxide/cGMP signalling pathway
    F Rodriguez-Pacheco
    Department of Cell Biology, Physiology and Immunology, University of Cordoba, Cordoba, Spain
    J Neuroendocrinol 20:406-12. 2008
    ..Taken together, our results provide novel evidence indicating that ghrelin requires activation of the NOS/NO route, and its subsequent GC/cGMP signal transduction pathway, as necessary steps to induce GH secretion from somatotrophs...
  11. ncbi Does nitric oxide modulate transmitter release at the mammalian neuromuscular junction?
    Travis J Nickels
    Center for Neuroscience, Department of Zoology, Miami University, Oxford, OH 45056, USA
    Clin Exp Pharmacol Physiol 34:318-26. 2007
    ..Our only modification to this model for the NMJ is that adenosine serves to block the modulation of transmitter release by NO...
  12. ncbi Role of the nitric oxide/cyclic GMP pathway and extracellular environment in the nitric oxide donor-induced increase in dopamine secretion from PC12 cells: a microdialysis in vitro study
    Pier Andrea Serra
    Department of Pharmacology, University of Sassari, Sassari, Italy
    J Neurochem 86:1403-13. 2003
    ..Extracellular Ca2+ entry may occur through nifedipine-insensitive channels. NO effects and DA concentrations in dialysates largely depend on both the timing of NO generation and the extracellular environment in which NO is generated...
  13. ncbi Nitric oxide decreases ammonium release in tadpoles of the clawed frog, Xenopus laevis, Daudin
    Stefan Wildling
    Division of Animal Physiology, Department of Cellular Biology, University of Salzburg, 5020 Salzburg, Austria
    J Comp Physiol B 177:401-11. 2007
    ..Based on our histochemical results, we speculate that gill epithelium and epidermis work in parallel to release ammonium as epidermal tissue contains mitochondria-rich and NADPH-diaphorase positive cells...
  14. ncbi Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea
    Hiroko Takeda-Nakazawa
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Fumizonocho 10 15, Moriguchi, Osaka 570 8507, Japan
    Hear Res 227:59-70. 2007
    ..NO conversely inhibits the Ca(2+) response via the NO-cGMP-PKG pathway by a feedback mechanism...
  15. ncbi Synaptic inputs onto spiking local interneurons in crayfish are depressed by nitric oxide
    Hitoshi Aonuma
    School of Biological Sciences, University of Southampton, Biomedical Sciences Building, Bassett Crescent East, Southampton SO16 7PX, United Kingdom
    J Neurobiol 52:144-55. 2002
    ..Moreover, application of NO scavengers modulates the inputs to these interneurons, suggesting that NO is continuously providing a powerful and dynamic means of modulating the outputs of local circuits...
  16. ncbi Requirement of protein tyrosine phosphatase SHP2 for NO-stimulated vascular smooth muscle cell motility
    C Brown
    Department of Physiology and Vascular Biology Center, University of Tennessee, Memphis, Tennessee 38163-0001, USA
    Am J Physiol Heart Circ Physiol 281:H1598-605. 2001
    ..These results support the hypothesis that NO-elicited upregulation of SHP2 via a cGMP-mediated pathway is necessary for NO-induced motogenesis in differentiated aortic smooth muscle cells...
  17. ncbi Role of nitric oxide in apoptosis of human peritoneal and adhesion fibroblasts after hypoxia
    Ghassan M Saed
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Wayne State University School of Medicine, The C S Mott Center for Human Growth and Development, Detroit, Michigan 48201, USA
    Fertil Steril 82:1198-205. 2004
    ..To study the modulation of the inducible nitric oxide synthase/nitric oxide (iNOS/NO) expression system in fibroblasts isolated from human peritoneum and adhesion tissues by hypoxia...
  18. pmc Nitric oxide inhibits the shedding of the glycosylphosphatidylinositol-anchored dipeptidase from porcine renal proximal tubules
    Sung Wook Park
    College of Pharmacy, Chonnam National University, 300 Yongbong Dong, Buk Gu, Kwangju 500 757, Korea
    Biochem J 364:211-8. 2002
    ..Therefore, this indicates a role for NO as an inhibitory regulator of the shedding of the GPI-anchored RDPase in acute renal failure...
  19. ncbi Intrathecally injected morphine inhibits inflammatory paw edema: the involvement of nitric oxide and cyclic-guanosine monophosphate
    Sara Comelli Brock
    Departamento de Farmacologia, CCB, Universidade Federal de Santa Catarina, Florianopolis, SC, 88040 900, Brasil
    Anesth Analg 106:965-71, table of contents. 2008
    ..t.) administration of morphine, and the involvement of spinal nitric oxide (NO)/cyclic-guanosine monophosphate-GMP pathway in carrageenan (CG)-induced paw edema...
  20. pmc Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments
    Leslie A Piggott
    Program in Cell and Regulatory Biology, The University of Texas Graduate School of Biomedical Sciences at Houston, 77225, USA
    J Gen Physiol 128:3-14. 2006
    ..These results suggest that cGMP signals are spatially segregated within cells, and that the functional compartmentalization of cGMP signals may underlie the unique actions of ANP and nitric oxide...
  21. ncbi Expression of nitric oxide synthases and in vitro migration of eosinophils from allergic rhinitis subjects
    Heloisa H A Ferreira
    Clinical Pharmacology and Gastroenterology Unit USF, USF, Braganca Paulista SP, Brazil
    Eur J Pharmacol 442:155-62. 2002
    ..In conclusion, both endothelial and inducible NO synthase isoforms are absent in allergic rhinitis eosinophils, suggesting that the NO cyclic GMP pathway in this cell type is maintained through the activity of a neuronal isoform...
  22. ncbi Nitric oxide protects rat hepatocytes against reperfusion injury mediated by the mitochondrial permeability transition
    Jae Sung Kim
    Department of Cell and Developmental Biology, School of Medicine, University of North Carolina, Chapel Hill, NC, USA
    Hepatology 39:1533-43. 2004
    ....
  23. ncbi Nitric oxide upregulates dimethylarginine dimethylaminohydrolase-2 via cyclic GMP induction in endothelial cells
    Maya Sakurada
    Department of Clinical and Molecular Endocrinology, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, Japan
    Hypertension 52:903-9. 2008
    ..Thus, the DDAH-2-ADMA/MMA-endothelial NO synthase regulatory pathway and NO-induced cGMP constitute a positive feedback loop that ultimately serves to maintain NO levels in the endothelial environment...
  24. ncbi Nitric oxide enhances Ca(2+)-dependent K(+) channel activity in rat carotid body cells
    Jeane M Silva
    Department of Pharmacology and Toxicology, Medical College of Georgia, 1120 15th Street, Augusta, GA 30912 2300, USA
    Pflugers Arch 443:671-5. 2002
    ....
  25. ncbi Progesterone production in bovine luteal cells treated with drugs that modulate nitric oxide production
    J J Jaroszewski
    Department of Pharmacology, Faculty of Veterinary Medicine, University of Warmia and Mazury in Olsztyn, Oczapowskiego 13, 10 719 Olsztyn, Poland
    Reproduction 125:389-95. 2003
    ....
  26. ncbi Pharmacological manipulation of nitric oxide levels in mouse follicle cultures demonstrates key role of extrafollicular control of ovulation
    Leila M Mitchell
    Department of Biological Sciences, University of Warwick, Coventry CV4 7AL, UK
    Hum Reprod 19:1705-12. 2004
    ..This study used a well-characterized system of isolated follicle culture to assess which isoforms of NOS might be involved at the follicular level...
  27. pmc Nitric oxide-an endogenous inhibitor of gastric acid secretion in isolated human gastric glands
    Anna Berg
    Department of Biomedicine and Surgery, Division of Cell Biology, Linkoping University, Sweden
    BMC Gastroenterol 4:16. 2004
    ..The present study was conducted to investigate the influence of exogenously and endogenously derived NO on histamine- and cAMP-stimulated gastric acid secretion in isolated human oxyntic glands...
  28. ncbi Arachidonic acid release by cPLA2 may be causally related to NO-induced apoptosis in vascular smooth muscle cells
    Cyril M Pilane
    Department of Pharmacology and Physiology, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA
    J Cell Physiol 191:191-7. 2002
    ..Arachidonic acid itself could induce apoptosis in the cultured cells. These observations provide evidence that arachidonate may be involved in apoptosis in vascular smooth muscle...
  29. ncbi Functional role of the soluble guanylyl cyclase alpha(1) subunit in vascular smooth muscle relaxation
    Sofie Nimmegeers
    Department of Physiology and Physiopathology, Ghent University, Ghent, Belgium
    Cardiovasc Res 76:149-59. 2007
    ..In vascular tissue sGCalpha(1)beta(1) is believed to be the most important. The aim of our study was to investigate the functional importance of the sGCalpha(1)-subunit in vasorelaxation...
  30. ncbi Methacholine-induced cGMP production is regulated by nitric oxide generation in rabbit submandibular gland cells
    Toshihiko Sakai
    Department of Physiology, Nihon University School of Dentistry at Matsudo, Chiba 271 8587, Matsudo, Japan
    Comp Biochem Physiol B Biochem Mol Biol 132:801-9. 2002
    ..These findings suggest that cGMP production induced by the activation of muscarinic cholinergic receptors is regulated by NO generation via the increase in [Ca2+]i...
  31. ncbi Nitric oxide stimulates a large-conductance Ca-activated K+ channel in human skin fibroblasts through protein kinase G pathway
    I Lim
    Department of Physiology, College of Medicine, Chung Ang University, Seoul, Korea
    Skin Pharmacol Physiol 18:279-87. 2005
    ....
  32. ncbi Nitric oxide modulates air embolism-induced lung injury in rats with normotension and hypertension
    Yen Chin Liu
    Department of Anaesthesiology, National Cheng Kung University, Tainan, Taiwan
    Clin Exp Pharmacol Physiol 34:1173-80. 2007
    ..Nitric oxide production through inducible NOS isoforms reduces air embolism-induced lung injury and associated changes. Spontaneously hypertensive rats appear to be more resistant than WKY rats to air embolism challenge...
  33. ncbi Acetylcholine inhibits the hypoxia-induced reduction of connexin43 protein in rat cardiomyocytes
    Yanan Zhang
    Department of Clinical Laboratory, Kochi Medical School, Japan
    J Pharmacol Sci 101:214-22. 2006
    ..These results suggest that ACh is responsible for restoring the decrease in the Cx43 protein level, resulting in functional activation of gap junctions...
  34. ncbi Inhibitory effects of NO on carotid body: contribution of neural and endothelial nitric oxide synthase isoforms
    Viviana Valdes
    Laboratorio de Neurobiologia, Facultad de Ciencias Biologicas, Pontificia Universidad Catolica de Chile, Casilla 114 D, Santiago 1, Chile
    Am J Physiol Lung Cell Mol Physiol 284:L57-68. 2003
    ..Our results suggest that both isoforms contribute to the NO action, but eNOS being the main source for NO in the cat CB and exerting a tonic effect upon chemoreceptor activity...
  35. ncbi Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion
    Paul Forsythe
    Pulmonary Research Group, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada
    J Immunol 170:287-93. 2003
    ..The inhibition of calpain is most likely mediated via nitrosylation of its active site thiol group. Calpain may represent a novel therapeutic target for the regulation of mast cell activity in inflammatory disorders...
  36. ncbi The role of adrenergic agonists on glycogenolysis in rat hepatocyte cultures and possible involvement of NO
    J Hodis
    Institute of Pharmacology First Faculty of Medicine, Charles University, Prague, Czech Republic
    Physiol Res 56:419-25. 2007
    ..iNOS gene expression was up-regulated by epinephrine. It can be concluded that glycogenolysis occurs through -adrenoceptor stimulation and a signaling cascade may involve NO production...
  37. ncbi NO/cGMP signaling and HSP90 activity represses metamorphosis in the sea urchin Lytechinus pictus
    C D Bishop
    Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada
    Biol Bull 201:394-404. 2001
    ..We propose that the production of NO repressively regulates the initiation of metamorphosis and that a sensory response to environmental cues reduces the production of NO, and consequently cGMP, to initiate metamorphosis...
  38. ncbi Nitric oxide blocks hKv1.5 channels by S-nitrosylation and by a cyclic GMP-dependent mechanism
    Lucía Núñez
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 72:80-9. 2006
    ..5, which generates the ultrarapid delayed rectifier current (IKur) that determines the height and duration of atrial action potentials...
  39. ncbi Hyposmotic stimulation-induced nitric oxide production in outer hair cells of the guinea pig cochlea
    Hiroko Takeda-Nakazawa
    Hearing Research Laboratory, Department of Otolaryngology, Kansai Medical University, Fumizonocho 10 15, Moriguchi, Osaka 570 8507, Japan
    Hear Res 230:93-104. 2007
    ..NO conversely inhibits the Ca2+ response via the NO-cGMP-PKG pathway by a feedback mechanism...
  40. ncbi Potentiation of nitric oxide-induced apoptosis in p53-/- vascular smooth muscle cells
    Melina R Kibbe
    Department of Surgery, University of Pittsburgh, 677 Scaife Hall, Pittsburgh, PA 15261, USA
    Am J Physiol Cell Physiol 282:C625-34. 2002
    ..Inhibition of p38 MAPK with SB-203580 or of MEK1/2 with PD-98059 blocked NO-induced apoptosis. Therefore, p53 may protect VSMC against NO-mediated apoptosis, in part, through differential regulation of MAPK pathways...
  41. ncbi Nitric oxide activates leak K+ currents in the presumed cholinergic neuron of basal forebrain
    Youngnam Kang
    Department of Neuroscience and Oral Physiology, Osaka University Graduate School of Dentistry, Suita, Osaka, Japan
    J Neurophysiol 98:3397-410. 2007
    ....
  42. pmc Does nitric oxide allow endothelial cells to sense hypoxia and mediate hypoxic vasodilatation? In vivo and in vitro studies
    Nicholas J Edmunds
    Department of Physiology, The Medical School, The University of Birmingham, Vincent Drive, Birmingham B15 2TT, UK
    J Physiol 546:521-7. 2003
    ..We propose that in vivo, shear-released NO increases the apparent K(m) of endothelial cytochrome oxidase for O(2), allowing the endothelium to act as an O(2) sensor, releasing adenosine in response to moderate falls in O(2)...
  43. ncbi Hypoxia enhances a cGMP-independent nitric oxide relaxing mechanism in pulmonary arteries
    Christopher J Mingone
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Am J Physiol Lung Cell Mol Physiol 285:L296-304. 2003
    ..2 mM) attenuated SNAP-mediated relaxation of BPA in the presence of ODQ. Thus hypoxic conditions appear to promote a cGMP-independent relaxation of BPA to NO by enhancing sarcoplasmic reticulum Ca2+ reuptake...
  44. ncbi Involvement of Ca2+/calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation
    Jean Christophe Schneider
    Service de Physiologie Explorations Fonctionnelles, Centre Hospitalier Universitaire Cochin, Assistance Publique, Hopitaux de Paris, Universite Paris 5, France
    Am J Physiol Heart Circ Physiol 284:H2311-9. 2003
    ..In rat aortic endothelial cells, KN-93 significantly decreased bradykinin-induced eNOS activity. These results suggest that CaMK II was involved in NO synthesis as a result of Ca(2+)-dependent activation of eNOS...
  45. ncbi NO inhibits Na+-K+-2Cl- cotransport via a cytochrome P-450-dependent pathway in renal epithelial cells (MMDD1)
    Hao He
    Department of Medicine, Ottawa Hospital, and the Kidney Research Centre, Ottawa Health Research Institute, University of Ottawa, Ottawa, Ontario, Canada K1H 8L6
    Am J Physiol Renal Physiol 284:F1235-44. 2003
    ..The results suggest that the inhibitory pathway is independent of cGMP and might involve stimulation of a cytochrome P-450-dependent pathway...
  46. ncbi Correlation between nitric oxide and cyclooxygenase-2 pathways in head and neck squamous cell carcinomas
    Oreste Gallo
    Department of Oto Neuro Ophthalmologic Surgery, University of Florence Medical School, 50134 Florence, Italy
    Biochem Biophys Res Commun 299:517-24. 2002
    ..Thus, in squamous carcinoma cells, NO increases the activity of COX-2 pathway and this effect is probably mediated by endocellular cGMP level, with potential implications on tumor growth, angiogenesis, and therapy...
  47. ncbi Increased vulnerability to ischemia/reperfusion-induced ventricular tachyarrhythmias by pre-ischemic inhibition of nitric oxide synthase in isolated rat hearts
    Koichi Kawahara
    Laboratory of Biomedical Control, Research Institute for Electronic Science, Hokkaido University, 060 0812, Sapporo, Japan
    Cardiovasc Pathol 12:49-56. 2003
    ..The objective of the present study was to clarify whether the vulnerability to reperfusion-induced VT/VF changes with preishemic, sustained inhibition of NOS...
  48. ncbi Nitric oxide induces [Ca2+]i oscillations in pituitary GH3 cells: involvement of IDR and ERG K+ currents
    Agnese Secondo
    Division of Pharmacology, Dept of Neuroscience, School of Medicine, Federico II Univ of Naples, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Cell Physiol 290:C233-43. 2006
    ..The present study suggests that in GH3 cells, endogenous NO plays a permissive role for the occurrence of spontaneous [Ca2+]i oscillations through an inhibitory effect on IDR and on IERG...
  49. ncbi Role of phosphodiesterase 3 in NO/cGMP-mediated antiinflammatory effects in vascular smooth muscle cells
    Toru Aizawa
    University of Rochester, Center for Cardiovascular Research, 601 Elmwood Ave, Box 679, Rochester, NY 14642, USA
    Circ Res 93:406-13. 2003
    ..These results suggest that SNAP and CNP exert inhibitory effects on NF-kappaB-dependent transcription by activation of PKA via cGMP-dependent inhibition of PDE3 activity. Therefore, PDE3 is a novel mediator of inflammation in VSMCs...
  50. ncbi Nitric oxide inhibits ischemia/reperfusion-induced myocardial apoptosis by modulating cyclin A-associated kinase activity
    Yasuhiro Maejima
    Department of Cardiovascular Medicine, Tokyo Medical and Dental University, 1 5 45 Yushima, Bunkyo, Tokyo 113 8519, Japan
    Cardiovasc Res 59:308-20. 2003
    ..This study was designated to elucidate novel apoptosis mechanisms induced by ischemia/reperfusion, especially the interaction between NO and cell cycle regulators...
  51. ncbi Nitric oxide donors alter cardiomyocyte cytokine secretion and cardiac function
    David L Maass
    Department of Surgery, UT Southwestern Medical Center, Dallas, TX, USA
    Crit Care Med 33:2794-803. 2005
    ....
  52. ncbi Regulation of connexin 43 by nitric oxide in primary uterine myocytes from term pregnant women
    Cheong Rae Roh
    Department of Obstetrics and Gynecology, Samsung Medical Center, and Center for Clinical Research, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Seoul, Korea
    Am J Obstet Gynecol 187:434-40. 2002
    ....
  53. ncbi Lipopolysaccharide-induced enterocyte-derived nitric oxide induces intestinal monolayer permeability in an autocrine fashion
    Raquel M Forsythe
    Department of Surgery, UMDNJ New Jersey Medical School, Newark 07103, USA
    Shock 17:180-4. 2002
    ..This supports the hypothesis that NO produced by LPS-stimulated enterocytes promotes injury in an autocrine fashion and highlights the fact that enterocytes can be a target as well as a producer of NO...
  54. ncbi Interaction of cyanide and nitric oxide with cytochrome c oxidase: implications for acute cyanide toxicity
    Heather B Leavesley
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907 1333, USA
    Toxicol Sci 101:101-11. 2008
    ..Also, the antidotal action of sodium nitrite is partly explained by generation of high mitochondrial levels of NO, which antagonizes the CcOX inhibition...
  55. ncbi Carnitine prevents NMDA receptor-mediated activation of MAP-kinase and phosphorylation of microtubule-associated protein 2 in cerebellar neurons in culture
    Marta Llansola
    Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, Fundacion Valenciana de Investigaciones Biomedicas, Amadeo de Saboya, 4, 46010, Valencia, Spain
    Brain Res 947:50-6. 2002
    ..These results indicate that carnitine interferes with NMDA-induced, nitric oxide mediated activation of MAP-kinase at a step subsequent to nitric oxide formation...
  56. ncbi Nitric oxide and its modulators in chronic constriction injury-induced neuropathic pain in rats
    Ajit K Naik
    Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar
    Eur J Pharmacol 530:59-69. 2006
    ..In conclusion, initial attempt to manipulate L-arginine: NO pathway is indicative of therapeutic potential of these interventions in the management of neuropathic pain...
  57. ncbi Nitric oxide synergistically potentiates interleukin-1 beta-induced increase of cyclooxygenase-2 mRNA levels, resulting in the facilitation of substance P release from primary afferent neurons: involvement of cGMP-independent mechanisms
    N Morioka
    Department of Pharmacology, Graduate School of Biomedical Sciences, Hiroshima University, Kasumi 1 2 3, Minami Ku, Hiroshima 734 8551, Japan
    Neuropharmacology 43:868-76. 2002
    ..The interaction between NO and COX in primary afferent neurons might contribute to the change in nociceptive perception in inflammatory hyperalgesia...
  58. ncbi Nitric oxide inhibits oocyte meiotic maturation
    Yasuhiko Nakamura
    Reproductive, Pediatric, and Infectious Science, Yamaguchi University School of Medicine, Ube 755 8505, Japan
    Biol Reprod 67:1588-92. 2002
    ..Finally, SNAP dose-dependently inhibited GVBD in denuded oocyte, and this effect of SNAP was reversed by the addition of hemoglobin. We conclude that the iNOS-NO-(cGMP) axis may play an important role in oocyte meiotic maturation...
  59. ncbi Enhanced nitric oxide-mediated chemoreceptor inhibition and altered cyclic GMP signaling in rat carotid body following chronic hypoxia
    L He
    Department of Physiology, University of Utah School of Medicine, Salt Lake City, UT 84108 6500, USA
    Am J Physiol Lung Cell Mol Physiol 293:L1463-8. 2007
    ..The data are consistent with the hypothesis that CH hampers cGMP-mediated inhibition of type I cells in favor of an alternative mechanism...
  60. ncbi Increased nitric oxide accounts for decreased basal vascular tone and responsiveness in the resistance vessels of high-cholesterol-fed rabbits
    R Fitch
    Department of Pharmacology, Berlex Biosciences, Richmond, CA 94804-0099, USA
    Pharmacology 63:220-7. 2001
    ..These results indicate that local overproduction of NO due to hypercholesteremia could desensitize smooth muscle reactivity, thus causing general vascular hyporesponsiveness to vasoactive agents...
  61. ncbi Mediators of non-adrenergic non-cholinergic inhibitory neurotransmission in porcine jejunum
    N M Matsuda
    Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Mayo Clinic, Rochester, MN, USA
    Neurogastroenterol Motil 16:605-12. 2004
    ..Pituitary adenylate cyclase activating peptide6-38 (1 micromol L(-1)) inhibited IJPs. These data suggest that inhibitory neurotransmission in pig jejunum is mediated partly by PACAP...
  62. ncbi Isoform-selective activation of protein kinase C by nitric oxide in the heart of conscious rabbits: a signaling mechanism for both nitric oxide-induced and ischemia-induced preconditioning
    P Ping
    Experimental Research Laboratory, Division of Cardiology, and the Department of Physiology and Biophysics, University of Louisville, Louisville, KY 40202, USA
    Circ Res 84:587-604. 1999
    ....
  63. pmc A comparison of EDHF-mediated and anandamide-induced relaxations in the rat isolated mesenteric artery
    R White
    Department of Pharmacology, University of Cambridge
    Br J Pharmacol 122:1573-84. 1997
    ....
  64. ncbi B-type natriuretic peptide at early reperfusion limits infarct size in the rat isolated heart
    Dwaine S Burley
    The Royal Veterinary College, University of London, London, UK
    Basic Res Cardiol 102:529-41. 2007
    ..Furthermore, endogenous activation of pGC could play a role in the mechanism of postconditioning...
  65. ncbi HAb18G/CD147 enhances the secretion of matrix metalloproteinases (MMP) via cGMP/NO-sensitive capacitative calcium entry (CCE) and accordingly attenuates adhesion ability of fibroblasts
    Yong Huang
    Cell Engineering Research Centre and Department of Cell Biology, The Fourth Military Medical University, Xi an 710032, PR China
    Eur J Cell Biol 84:59-73. 2005
    ..These results suggest that HAb18G/CD147 attenuates adhesion potentials in fibroblasts by enhancing the secretion of MMP through NO/cGMP-sensitive capacitative Ca2+ entry...
  66. pmc Effect of some cyclooxygenase inhibitors on the increase in guanosine 3':5'-cyclic monophosphate induced by NO-donors in human whole platelets
    P Failli
    Dipartimento di Farmacologia Preclinica e Clinica Mario Aiazzi Mancini, Universita degli Studi di Firenze, Italy
    Br J Pharmacol 123:1457-63. 1998
    ....
  67. ncbi Effects of estrous synchronization on response to nitric oxide donors, nitric oxide synthase inhibitors, and endothelin-1 in vitro
    Y S Weems
    Department of Human Nutrition, Food and Animal Sciences, University of Hawaii, Honolulu, HI 96822, USA
    Prostaglandins Other Lipid Mediat 74:45-59. 2004
    ..It is suggested that NO and ET-1 could have indirect antiluteolytic/luteotropic effects via increasing PGE2 secretion by luteal tissue rather than being luteolytic...
  68. ncbi Transduction capabilities of neonatal ventricular afferent neurons in vivo
    R P Chen
    Department of Pediatrics, Faculty of Medicine, Daihousie University, Halifax, Nova Scotia, Canada B3H 4H7
    Auton Neurosci 87:1-8. 2001
    ..That cardiac afferent neurons are capable of sensing the mechanical and chemical milieu of the neonatal heart should be taken into account when considering altered neonatal cardiovascular status such as occurs during apnea...
  69. ncbi TGF-beta1 inhibits expression and activity of hENT1 in a nitric oxide-dependent manner in human umbilical vein endothelium
    Jose L Vega
    Cellular and Molecular Physiology Laboratory, Department of Obstetrics and Gynaecology, Medical Research Centre CIM, School of Medicine, Faculty of Medicine, Pontificia Universidad Catolica de Chile, PO Box 114 D, Santiago, Chile
    Cardiovasc Res 82:458-67. 2009
    ..TGF-beta1 increases NO synthesis via activation of TGF-beta receptor type II (TbetaRII), and NO inhibits hENT1 expression and activity in HUVECs...
  70. ncbi Superoxide generation links protein kinase C activation to impaired ATP-sensitive K+ channel function after brain injury
    W M Armstead
    Departments of Anesthesia and Pharmacology, University of Pennsylvania and The Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    Stroke 30:153-9. 1999
    ..These data suggest, therefore, that O2- generation links PKC activation to impaired KATP channel function after FPI...
  71. ncbi Nitric oxide suppresses NADPH oxidase-dependent superoxide production by S-nitrosylation in human endothelial cells
    Stavros Selemidis
    Bernard O Brien Institute of Microsurgery, University of Melbourne, Fitzroy, Victoria 3065, Australia
    Cardiovasc Res 75:349-58. 2007
    ..Here we investigate the regulation of NADPH oxidase activity by nitric oxide (NO)...
  72. ncbi Nitric oxide donor-induced increase in permeability of the blood-brain barrier
    W G Mayhan
    Department of Physiology and Biophysics, University of Nebraska Medical Center, Omaha, NE 68198 4575, USA
    Brain Res 866:101-8. 2000
    ..We suggest that increases in NO formation observed during brain trauma may contribute to disruption of the blood-brain barrier...
  73. ncbi Nitric oxide-dependent down-regulation of angiotensin II type 2 receptors during experimental sepsis
    M Bucher
    Department of Anesthesiology, University of Regensburg, Regensburg, Germany
    Crit Care Med 29:1750-5. 2001
    ..In addition, the influence of typical endogenous mediators of sepsis, such as proinflammatory cytokines and nitric oxide, on AT2 receptor expression should be investigated in vitro...
  74. ncbi Nitric oxide regulates the 26S proteasome in vascular smooth muscle cells
    Muneera R Kapadia
    Division of Vascular Surgery and the Institute for BioNanotechnology in Medicine, Northwestern University, 676 N St Clair Street 650, Chicago, IL 60611, USA
    Nitric Oxide 20:279-88. 2009
    ..This may be one mechanism by which NO exerts its effects on the cell cycle and inhibits cellular proliferation in the vasculature...
  75. pmc Nitric oxide induces stomatal closure and enhances the adaptive plant responses against drought stress
    C Garcia-Mata
    Instituto de Investigaciones Biologicas, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata, CC 1245, 7600 Mar del Plata, Argentina
    Plant Physiol 126:1196-204. 2001
    ..All together, these results suggest that the exogenous application of NO donors might confer an increased tolerance to severe drought stress conditions in plants...
  76. pmc Nitric oxide, prostanoid and non-NO, non-prostanoid involvement in acetylcholine relaxation of isolated human small arteries
    N H Buus
    Department of Pharmacology, University of Aarhus, 8000 Aarhus C, Denmark Department of Thoracic Surgery, Aarhus University Hospital, Aarhus, Denmark
    Br J Pharmacol 129:184-92. 2000
    ..However, ACh relaxation is mainly dependent on a non-NO, non-prostanoid endothelium dependent hyperpolarization. British Journal of Pharmacology (2000) 129, 184 - 192..
  77. pmc Nitric oxide selectively depletes macrophages in atherosclerotic plaques via induction of endoplasmic reticulum stress
    W Martinet
    Division of Pharmacology, University of Antwerp, Wilrijk, Belgium
    Br J Pharmacol 152:493-500. 2007
    ..In this study, we investigated the underlying mechanism...
  78. ncbi S-nitroso-N-acetylpenicillamine and nitroprusside induce apoptosis in a neuronal cell line by the production of different reactive molecules
    D Terwel
    Department of Psychiatry and Neuropsychology, European Graduate School of Neuroscience EURON, Maastricht University, P O Box 616, 6200 MD, Maastricht, Netherlands
    Eur J Pharmacol 400:19-33. 2000
    ....
  79. pmc Downregulation of carbon monoxide as well as nitric oxide contributes to peripheral chemoreflex hypersensitivity in heart failure rabbits
    Yanfeng Ding
    Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE 68198 5850, USA
    J Appl Physiol (1985) 105:14-23. 2008
    ..63 +/- 0.04, 0.56 +/- 0.06, and 0.27 +/- 0.03, respectively) rabbits (P < 0.05). These results suggest that a deficiency of NO and CO in the CBs augments peripheral chemoreflex sensitivity to hypoxia in CHF...
  80. ncbi Chemical induction of rapid and reversible plastid filamentation in Arabidopsis thaliana roots
    Ryuuichi D Itoh
    Department of Chemistry, Biology and Marine Science, Faculty of Science, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa 903 0213, Japan
    Physiol Plant 139:144-58. 2010
    ....
  81. ncbi Responses of differentiated MC3T3-E1 osteoblast-like cells to reactive oxygen species
    Amos A Fatokun
    Institute of Biomedical and Life Sciences, Room 345, West Medical Building, University of Glasgow, Glasgow G12 8QQ, Scotland, UK
    Eur J Pharmacol 587:35-41. 2008
    ..This study gives new insight into how bone cells may succumb to the toxic effects of oxidative stress generated by different stimuli and has relevance to conditions such as osteoporosis...
  82. pmc Evidence for S-nitrosothiol-dependent changes in fibrinogen that do not involve transnitrosation or thiolation
    Shirin Akhter
    Department of Chemistry and Biochemistry, University of Windsor, Windsor, ON, Canada N9B
    Proc Natl Acad Sci U S A 99:9172-7. 2002
    ..Three such putative RSNO-binding domains have been identified in the unordered, aromatic residue-rich C-termini of the alpha-chains of fibrinogen...
  83. ncbi Nitric oxide modulates stretch activation of mitogen-activated protein kinases in mesangial cells
    A J Ingram
    Department of Medicine, McMaster University Hamilton, and University of Toronto, Ontario, Canada
    Kidney Int 58:1067-77. 2000
    ..Consequently, we studied whether NO could affect SAPK and p42/44 MAPK activation in stretched MCs...
  84. ncbi Reversal of attenuation of cerebrovascular reactivity to hypercapnia by a nitric oxide donor after controlled cortical impact in a rat model of traumatic brain injury
    Fangyi Zhang
    Department of Surgery, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Neurosurg 97:963-9. 2002
    ....
  85. ncbi The muscarinic acetylcholine receptor-stimulated increase in aquaporin-5 levels in the apical plasma membrane in rat parotid acinar cells is coupled with activation of nitric oxide/cGMP signal transduction
    Yasuko Ishikawa
    Department of Pharmacology, Tokushima University School of Dentistry, Tokushima, Japan
    Mol Pharmacol 61:1423-34. 2002
    ..These results suggest that NO/cGMP signal transduction has a crucial role in Ca(2+) homeostasis in the mAChR-stimulated increase in AQP5 levels in the APM of rat parotid glands...
  86. pmc Smooth muscle cell expression of type I cyclic GMP-dependent protein kinase is suppressed by continuous exposure to nitrovasodilators, theophylline, cyclic GMP, and cyclic AMP
    G A Soff
    Department of Medicine, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Clin Invest 100:2580-7. 1997
    ..These data may contribute to our understanding of nitrovasodilator resistance, a phenomenon resulting from continuous exposure to nitroglycerin or other nitrovasodilators...
  87. ncbi Evidence for hydroxyl radical scavenging action of nitric oxide donors in the protection against 1-methyl-4-phenylpyridinium-induced neurotoxicity in rats
    Rebecca Banerjee
    Division of Cell Biology and Physiology, Laboratory of Clinical and Experimental Neuroscience, Indian Institute of Chemical Biology, 4, Raja S C Mullick Road, Kolkata 700 032, India
    Neurochem Res 33:985-95. 2008
    ..These results confirm the involvement of *OH in the nigrostriatal degeneration caused by MPP+, indicate the *OH scavenging ability of NO*, and demonstrate protection by NO* donors against MPP+-induced dopaminergic neurotoxicity in rats...
  88. ncbi Extracellular renal guanosine cyclic 3'5'-monophosphate modulates nitric oxide and pressure-induced natriuresis
    Farah Ahmed
    Division of Endocrinology and Metabolism, Department of Medicine, University of Virginia Health Sciences Center, Charlottesville, USA
    Hypertension 50:958-63. 2007
    ..Extracellular cGMP modulates NO- and pressure-induced natriuresis...
  89. pmc Differential contributions of nitric oxide synthase isoforms at hippocampal formation to negative feedback regulation of penile erection in the rat
    Alice Y W Chang
    Center for Neuroscience, National Sun Yat Sen University, Kuohsiung 804, Republic of China
    Br J Pharmacol 136:1-8. 2002
    ..Neither of these inhibitors, furthermore, affected baseline ICP. These results suggest that NO generated via both neuronal and inducible NOS at the HF may participate in negative feedback regulation of penile erection...
  90. pmc The effect of nitric oxide donors on haemodynamics and blood flow distribution in the porcine carotid circulation
    E M Van Gelderen
    Department of Pharmacology, Cardiovascular Research Institute COEUR, Faculty of Medicine and Health Sciences, Erasmus University Rotterdam, The Netherlands
    Br J Pharmacol 114:1303-9. 1995
    ....
  91. ncbi Nitric oxide induces dose-dependent CA(2+) transients and causes temporal morphological hyperpolarization in human neutrophils
    V M Loitto
    Department of Medical Microbiology, Faculty of Health Sciences, Linkoping University, Linkoping, Sweden
    J Cell Physiol 182:402-13. 2000
    ..e., Ca(2+) homeostasis, and also affect cell migration, e.g., through effects on F-actin turnover. Our results are discussed in relation to the complex mechanisms that govern basic cell shape changes, required for migration...
  92. ncbi Reduced l-arginine transport and nitric oxide synthesis in human umbilical vein endothelial cells from intrauterine growth restriction pregnancies is not further altered by hypoxia
    P Casanello
    Perinatology Research Laboratory and Cellular and Molecular Physiology Laboratory, Department of Obstetrics and Gynecology, Faculty of Medicine, School of Medicine, Pontificia Universidad Catolica de Chile, Santiago, Chile
    Placenta 30:625-33. 2009
    ..These mechanisms could be responsible for placental dysfunction in diseases where fetal endothelium is chronically exposed to hypoxia, such as IUGR...
  93. ncbi Effect of nitric oxide donors on oxygen-dependent cytotoxic responses mediated by neutrophils
    G Andonegui
    Laboratory of Immunology, Institute of Hematologic Research, National Academy of Medicine, Buenos Aires, Argentina
    J Immunol 162:2922-30. 1999
    ..e., 8 or 18 h) further increased cytotoxicity. Not only cytotoxic responses, but also the production of O2- and H2O2, and the release of myeloperoxidase were increased under these conditions...
  94. ncbi Vascular potassium channels mediate oxygen-induced pulmonary vasodilation in fetal lambs
    S Mital
    Department of Pediatrics, Children s Hospital of Michigan, Wayne State University School of Medicine, Detroit, Mich, USA
    Biol Neonate 77:58-68. 2000
    ..In conclusion, K+ channels mediate oxygen-induced pulmonary vasodilation in fetal lambs. K(ATP) channels appear to mediate EDNO release, while K(Ca) channels probably mediate NO effects on vascular smooth muscle...
  95. ncbi Vasodilator responses to acetylcholine, bradykinin, and substance P are mediated by a TEA-sensitive mechanism
    H C Champion
    Department of Pharmacology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA
    Am J Physiol 273:R414-22. 1997
    ....
  96. pmc Pacemaker frequency is increased by sodium nitroprusside in the guinea pig gastric antrum
    Yoshihiko Kito
    Department of Physiology, Nagoya City University Medical School, Mizuho ku, Nagoya 467 8601, Japan
    J Physiol 546:191-205. 2003
    ....
  97. ncbi Nitric oxide donor-induced hyperpermeability of cultured intestinal epithelial monolayers: role of superoxide radical, hydroxyl radical, and peroxynitrite
    M J Menconi
    Department of Surgery, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Biochim Biophys Acta 1425:189-203. 1998
    ..These results support a role for PN, and possibly OH*, in the pathogenesis of NO* donor-induced intestinal epithelial hyperpermeability...
  98. ncbi Estriol improves membrane fluidity of erythrocytes by the nitric oxide-dependent mechanism: an electron paramagnetic resonance study
    K Tsuda
    Department of Medicine, Wakayama Medical University, Japan
    Hypertens Res 24:263-9. 2001
    ..Furthermore, the data might be consistent with the hypothesis that E3 could have a beneficial effect on the rheological behavior of erythrocytes and may play a crucial role in the regulation of microcirculation...
  99. ncbi Nitric oxide generators and cGMP stimulate mucus secretion by rat gastric mucosal cells
    J F Brown
    Pharmaceutical Sciences Institute, Aston University, Birmingham, United Kingdom
    Am J Physiol 265:G418-22. 1993
    ..These findings, along with the presence of NO synthase in the gastric epithelial cells, suggest an effector role for NO in mediation of gastric mucus release...
  100. ncbi The effects of nitric oxide-oxidase and putative glutathione-peroxidase activities of ceruloplasmin on the viability of cardiomyocytes exposed to hydrogen peroxide
    Mylène Paradis
    Département de Chimie et de biochimie and Centre Biomed, Universite du Quebec a Montreal, Montreal, QC, Canada
    Free Radic Biol Med 49:2019-27. 2010
    ..This increase was canceled by PAPA/NO. CP's putative GSH-peroxidase activity can thus provide cytoprotection but is possibly affected by the S-nitrosation of a catalytically important cysteine residue...
  101. ncbi Mutagenicity and cytotoxicity of reactive oxygen and nitrogen species in the MN-11 murine tumor cell line
    J K Sandhu
    Department of Microbiology and Immunology, University of Ottawa, Ont, Canada
    Mutat Res 379:241-52. 1997
    ..may be generated and these may vary in their mutagenic/cytotoxic potential...

Research Grants60

  1. CYTOSTATIC ROLE OF THE ARGININE-NITRIC OXIDE PATHWAY
    Louis Ignarro; Fiscal Year: 2001
    ..The proposed research should advance our understanding of the biological role of NO synthase in regulating cell proliferation. ..
  2. Apoptotic mechanisms in NSAID chemoprevention
    STEVEN DAMBROSIO; Fiscal Year: 2008
    ..abstract_text> ..
  3. Arginase and Nitric Oxide in Atherosclerosis
    Louis Ignarro; Fiscal Year: 2004
    ..The feasibility of this approach is borne out by the extensive preliminary data that support the central hypothesis. ..
  4. REGULATION OF EXPRESSION OF NO SYNTHASE
    Louis Ignarro; Fiscal Year: 2002
    ..The proposed research represents a continuing long-term effort to elucidate the biological factors influencing the vascular and related actions of NO in health and disease. ..
  5. Noninvasive Monitoring of In Situ Oxygenation and Cell Therapy in Infarct Heart
    Periannan Kuppusamy; Fiscal Year: 2010
    ..The availability of these innovative probes and technologies will enhance our ability to monitor cell therapy and should open new avenues in the treatment of heart disease in humans. ..
  6. In Vivo EPR Imaging of Redox Status and Thiols in Tumor
    Periannan Kuppusamy; Fiscal Year: 2007
    ..The results will enable a better understanding of the development of drug resistance in ovarian cancer and offer efficient diagnosis for effective treatment of ovarian cancer patients. ..
  7. Modulation of Diabetic Kidney Growth/ Hypertrophy
    Joseph Satriano; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  8. Cyclic AMP signaling in cardiac myocytes
    THOMAS RICH; Fiscal Year: 2007
    ..g., protenoid, beta1-,or beta2-adrenergic receptors) or inhibit phosphodiesterase (PDE) will shed new light on the physiologic functions of these enzymes and their relation to cardiac function. ..
  9. Nitric Oxide-Mediated Pulmonary Vasodilation After Chronic Hypoxia
    Thomas Resta; Fiscal Year: 2007
    ..Findings from studies are expected to fundamentally advance our understanding of signal transduction mechanisms by which PKG regulates pulmonary vascular tone, as well as adaptive responses of the pulmonary circulation to CH. ..
  10. Interaction of COX-2 AND nNOS in renin secretion (R01)
    Tianxin Yang; Fiscal Year: 2008
    ..abstract_text> ..
  11. Effect of Adenosine A2 receptor activation on the mitochondrial death pathway
    Zhelong Xu; Fiscal Year: 2010
    ....
  12. Novel Methods for in Vivo Imaging of Tissue Oxygenation
    Periannan Kuppusamy; Fiscal Year: 2008
    ..The technology should offer exciting new opportunities in the field of biomedical imaging of free radicals and oxygen. ..
  13. Neurophysiology and Biomechanics of Urethra in Stress Urinary Incontinence
    Naoki Yoshimura; Fiscal Year: 2008
    ..This is recognized as a high priority in the urologic/gynecologic care of SUI patients. [unreadable] [unreadable]..
  14. VEGF Regulation of Microvascular Permeability
    Mack Wu; Fiscal Year: 2008
    ..abstract_text> ..
  15. NOS1/NOS3 Functional Effects on Cardiac Myocyte Function
    Mark T Ziolo; Fiscal Year: 2010
    ..The relevance of this proposal to public health is that these results may improve the treatment of heart disease by potentially identifying new targets for drug development. ..
  16. Regulation of Oxidative Stress in the mdx Diaphragm
    JOHN LAWLER; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  17. Liberation of Intracellular Zinc and Neuronal Cell Death
    Elias Aizenman; Fiscal Year: 2007
    ..With this information, we hope to uncover novel therapeutic strategies to prevent or halt the progression of these and other neurodegenerative conditions. ..
  18. cAMP Phosphodiesterase and Lung Endothelial Cell Permeability
    Thomas C Rich; Fiscal Year: 2010
    ..Here we propose to determine whether pharmacological and molecular inhibitors of a specific protein, phosphodiesterase type 7, prevent increases in endothelial permeability in these arteries, and hence, make breathing easier. ..
  19. AFFERENT PLASTICITY UNDERLYING URETHRAL AND PELVIC PAIN
    Naoki Yoshimura; Fiscal Year: 2010
    ..This is recognized as a high priority in the urologic care of patients with IC/CPPS. ..
  20. Nitric oxide and mitochondrial biogenesis in sepsis
    Claude A Piantadosi; Fiscal Year: 2010
    ..abstract_text> ..
  21. Tool to Define the Antiproliferative Effects of Agmatine
    Joseph Satriano; Fiscal Year: 2006
    ..These pathways will have particular application to diabetes and IRI in kidney, models we plan to pursue. [unreadable] [unreadable]..
  22. Bladder Pain Gene Therapy with Pro-opiomelanocortin cDNA
    Naoki Yoshimura; Fiscal Year: 2004
    ..This research project is important to provide a solid basis for potential future clinical application. ..
  23. MODULATION OF NMDA RECEPTORS
    Elias Aizenman; Fiscal Year: 2003
    ..In addition, the investigations proposed here will focus on a novel form of modulation of NMDA receptor function, which may be important in retinal physiology. ..
  24. CONFERENCE/WORKSHOP ON EPR SPECTROSCOPY AND IMAGING
    Periannan Kuppusamy; Fiscal Year: 2005
    ..S. members of the International Advisory Committee for this meeting. Particular emphasis will be given to the minority and women scientists, encouraging their active participation. ..
  25. CILIARY FUNCTION AND DIFFERENTIATION OF AIRWAY EPITHELIA
    Matthias Salathe; Fiscal Year: 2005
    ..Furthermore, the studies using microarrays will generate new information on specific signaling pathways and may well serve to identify components of regulatory pathways that were unknown. ..
  26. EPR IMAGING OF TUMOR HETEROGENEITY AND OXYGENATION
    Periannan Kuppusamy; Fiscal Year: 2003
    ..Information obtained from these studies should enable the development and optimization of therapeutic modalities for cancer treatment. ..
  27. Lower urinary tract dysfunction in Parkinson's disease
    Naoki Yoshimura; Fiscal Year: 2003
    ..This is a high priority in the urologic care of patients with Parkinson's disease. ..
  28. 2005 Cilia, Mucus, and Mucociliary Interactions GRC
    Matthias Salathe; Fiscal Year: 2005
    ..Finally, poster sessions will complement the plenary sessions and free afternoons will further enable idea exchanges between scientists. ..
  29. Role of DEG/ENaC in the renal myogenic response
    NIKKI JERNIGAN; Fiscal Year: 2005
    ..abstract_text> ..
  30. SUMMER RESEARCH EXPERIENCES FOR UNDERGRADUATES
    Neil Hogg; Fiscal Year: 2006
    ..The success of the program will be closely monitored by follow-up questionnaires to both students and participating faculty. ..
  31. CONTROL OF OXYGENATION DURING POSTNATAL LIFE
    PHILIP NOWICKI; Fiscal Year: 2002
    ..These data should provide justification for moving the next renewal cycle of this work into studying receptor biochemistry in tissue removed from human infants undergoing bowel resection of NEC or non-NEC reasons. ..
  32. Effect of Raloxifene on Neuronal Physiology
    Teresa Audesirk; Fiscal Year: 2002
    ..The production of NO, which has been implicated in several aspects of neuronal differentiation and learning, is enhanced by b-estradiol. This enhancement is blocked by the SERM tamoxifen. ..
  33. Tissue-specific defects from lamin A/C gene mutations.
    JULIE JI; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  34. REGULATION OF PULMONARY RESISTANCE VESSELS
    Judy Aschner; Fiscal Year: 2002
    ....
  35. NICOTINE INDUCED CEREBROVASCULAR DYSFUNCTION
    WILLIAM MAYHAN; Fiscal Year: 2006
    ..In addition, results of these studies may provide insights regarding possible therapeutic approaches for the treatment of nicotine-induced vascular dysfunction. ..
  36. Agmatine Mediated Arrest of Proliferation
    Joseph Satriano; Fiscal Year: 2003
    ..UCSD has established itself as a leading academic institution and thus provides an excellent environment for the exchange of ideas and techniques essential for the growth of the PI's career. ..
  37. Cerebral Microcirculation During Alcohol Consumption
    WILLIAM MAYHAN; Fiscal Year: 2008
    ..These studies will provide valuable new insights and will lead to new therapeutic approaches for the treatment of cerebrovascular abnormalities observed in chronic alcoholics. [unreadable] [unreadable]..
  38. Mechanism of Metabolism of S-Nitrosothiols
    Neil Hogg; Fiscal Year: 2010
    ..Importantly, these studies will point to a role of RSNO formation not simply as 'carriers'of NO bioactivity but as a distinct bifurcation in NO signaling pathways. ..
  39. Mechanisms Underlying the Cognitive Function of Sleep
    Subimal Datta; Fiscal Year: 2009
    ....
  40. PULMONARY VASODILATION AND GUANYLATE CYCLASE REGULATION
    Michael S Wolin; Fiscal Year: 2010
    ....
  41. Lung Injury Protection by Coagulation Blockade
    CLAUDE PIANTADOSI; Fiscal Year: 2008
    ..A successfully optimized strategy could greatly attenuate persistence of pulmonary inflammation and facilitate the resolution of human ARDS. ..
  42. Renal medullary COX-2 in blood pressure control
    Tianxin Yang; Fiscal Year: 2008
    ..The information resulted from these studies will provide new insight into the molecular mechanism responsible for long-term control of arterial blood pressure. ..
  43. Cerebrovascular Disease in Type 1 Diabetes
    WILLIAM MAYHAN; Fiscal Year: 2007
    ..We suggest that our results will provide novel insights regarding therapeutic approaches for the treatment/prevention of cerebrovascular dysfunction in diabetes. ..
  44. Afferent modulation in bladde dysfunction
    Naoki Yoshimura; Fiscal Year: 2007
    ..abstract not provided ..
  45. Hsp90/Client Protein Interactions in the Newborn Lung
    Judy Aschner; Fiscal Year: 2008
    ..These studies will improve understanding of the neonatal pulmonary hypertensive response to chronic hypoxia and are critical to the formulation of novel treatment strategies for infants with PH. ..
  46. Alcohol Injury Healing, Cytoprotection and Survivin
    Michael Jones; Fiscal Year: 2009
    ..Information gained from these studies will lead to better understanding of the mechanisms underlying ETOH-induced injury and will provide for the development of better therapeutics for treating ETOH-induced injury. ..
  47. MECHANISMS OF NO-MEDIATED PROTEIN S-NITROSYLATION IN EAE
    OSCAR BIZZOZERO; Fiscal Year: 2007
    ..abstract_text> ..
  48. TGF-beta 1-regulated IL-8 expression in prostate cancer
    Zhongyun Dong; Fiscal Year: 2007
    ..TGF-beta1-stimulated IL-8 expression and IL-8 gene promoter activation in cells lacking the three TGF-beta signaling pathways as well as transcription factors involved will be determined. ..
  49. REACTIVE OXYGEN SPECIES AND VASCULAR O2 SENSING
    Michael S Wolin; Fiscal Year: 2010
    ..These studies should help define the origins of differences in physiological responses of pulmonary and coronary arteries to changes in O2 tension. ..
  50. Generation of Collecting Duct Knockout of PPARgamma
    Tianxin Yang; Fiscal Year: 2006
    ..New information provided by this proposal is expected to provide insights into the roles of PPARgamma in regulation of fluid balance and in mediation of the side effects of TDZ. ..
  51. NITRIC OXIDE, PLP ACYLATION & THE PATHOPHYSIOLOGY OF MS
    OSCAR BIZZOZERO; Fiscal Year: 2003
    ..abstract_text> ..
  52. Brain Manganese Deposition in High Risk Neonates
    Judy Aschner; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  53. Ethanol Effects on Antigen Presentation in Liver Cells
    Natalia Osna; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  54. Pressure Induced Dynamic 3D Changes in Lamina Cribrosa
    Donald Brown; Fiscal Year: 2008
    ..This technique allows for direct measurement of the structural changes in the associated with glaucoma and has direct clinical relevance and application. [unreadable] [unreadable] [unreadable]..
  55. VEGF and Nitric Oxide in Lung Vascular Development
    Vivek Balasubramaniam; Fiscal Year: 2007
    ..In addition, Dr. Balasubramaniam will continue to work with Dr. Charles Plopper (UC Davis) to learn more sophisticated techniques of morphometric analysis. ..
  56. Mitochondria and regulation of HIF-1
    Faton Agani; Fiscal Year: 2004
    ....
  57. Metabolic Biomarkers of Autism: Predictive Potential and Genetic Susceptibility
    SANDRA JILL JAMES; Fiscal Year: 2010
    ....
  58. Interaction of COX-2 and nNOS in renin secretion
    Tianxin Yang; Fiscal Year: 2006
    ....
  59. AGING AND ENDOTHELIAL CELL FUNCTION
    May Reed; Fiscal Year: 2009
    ..The elucidation of mechanisms that regulate MMP activity in aged cells and tissues will assist the development of therapies to improve wound repair and revascularization of ischemic organs. ..
  60. Aging and the Microvasculature
    May Reed; Fiscal Year: 2006
    ..The results will define the key points of deficient microvascular growth in the aged and also develop the microvessel sprout model into a highly useful tool for studies of vascular growth in general. ..