reactive nitrogen species

Summary

Summary: Nitrogenous products of NITRIC OXIDE synthases, ranging from NITRIC OXIDE to NITRATES. These reactive nitrogen intermediates also include the inorganic PEROXYNITROUS ACID and the organic S-NITROSOTHIOLS.

Top Publications

  1. ncbi Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis
    Bice Fubini
    Department of Chemistry IFM and Interdepartmental Center G Scansetti for Studies on Asbestos and other Toxic Particulates, University of Torino, Torino, Italy
    Free Radic Biol Med 34:1507-16. 2003
  2. ncbi Nitroxidative, nitrosative, and nitrative stress: kinetic predictions of reactive nitrogen species chemistry under biological conditions
    Jack R Lancaster
    Department of Anesthesiology, Environmental Health Sciences, and Physiology and Biophysics, Center for Free Radical Biology, The University of Alabama Birmingham, 35294, USA
    Chem Res Toxicol 19:1160-74. 2006
  3. ncbi Metabolism of reactive oxygen species and reactive nitrogen species in pepper (Capsicum annuum L.) plants under low temperature stress
    Morad Airaki
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Apartado 419, E 18080 Granada, Spain
    Plant Cell Environ 35:281-95. 2012
  4. ncbi Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts
    Marilyn Chwa
    Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
    Invest Ophthalmol Vis Sci 47:1902-10. 2006
  5. ncbi Interaction of bilirubin and biliverdin with reactive nitrogen species
    Harparkash Kaur
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Y Block, Middlesex HA1 3UJ, Harrow, UK
    FEBS Lett 543:113-9. 2003
  6. ncbi Reactive nitrogen species in the chemical biology of inflammation
    Peter C Dedon
    Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Arch Biochem Biophys 423:12-22. 2004
  7. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
  8. ncbi Metabolism of reactive nitrogen species in pea plants under abiotic stress conditions
    Francisco J Corpas
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, E 18080 Granada, Spain
    Plant Cell Physiol 49:1711-22. 2008
  9. ncbi Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species
    Caryn Vadseth
    Stokes Research Institute and Department of Biochemistry and Biophysics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biol Chem 279:8820-6. 2004
  10. ncbi Reactive nitrogen species in the respiratory tract
    Fabio L M Ricciardolo
    Unit of Pneumology, IRCCS Gaslini Institute, Largo G Gaslini 5, 16147 Genoa, Italy
    Eur J Pharmacol 533:240-52. 2006

Detail Information

Publications272 found, 100 shown here

  1. ncbi Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis
    Bice Fubini
    Department of Chemistry IFM and Interdepartmental Center G Scansetti for Studies on Asbestos and other Toxic Particulates, University of Torino, Torino, Italy
    Free Radic Biol Med 34:1507-16. 2003
    ..Silica can also initiate apoptosis in response to oxygen- and nitrogen-based free radicals, leading to mitochondrial dysfunction, increased gene expression of death receptors, and/or their ligands (TNFalpha, Fas ligand [FasL])...
  2. ncbi Nitroxidative, nitrosative, and nitrative stress: kinetic predictions of reactive nitrogen species chemistry under biological conditions
    Jack R Lancaster
    Department of Anesthesiology, Environmental Health Sciences, and Physiology and Biophysics, Center for Free Radical Biology, The University of Alabama Birmingham, 35294, USA
    Chem Res Toxicol 19:1160-74. 2006
    A freely available Windows-based program, RNSim1A, is utilized to predict metal-independent reactive nitrogen species (RNS) chemistry (oxidation, nitrosation, and nitration) under simulated biological conditions and make the following ..
  3. ncbi Metabolism of reactive oxygen species and reactive nitrogen species in pepper (Capsicum annuum L.) plants under low temperature stress
    Morad Airaki
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, Apartado 419, E 18080 Granada, Spain
    Plant Cell Environ 35:281-95. 2012
    ..This suggests that ascorbate, glutathione and the NADPH-generating dehydrogenases have a role in the process of cold acclimation through their effect on the redox state of the cell...
  4. ncbi Increased stress-induced generation of reactive oxygen species and apoptosis in human keratoconus fibroblasts
    Marilyn Chwa
    Department of Ophthalmology, University of California Irvine Medical Center, Irvine, California, USA
    Invest Ophthalmol Vis Sci 47:1902-10. 2006
    ..To determine whether keratoconus (KC) corneal fibroblast cultures have increased reactive oxygen species (ROS) production and are more susceptible to stress-related challenges...
  5. ncbi Interaction of bilirubin and biliverdin with reactive nitrogen species
    Harparkash Kaur
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Watford Road, Y Block, Middlesex HA1 3UJ, Harrow, UK
    FEBS Lett 543:113-9. 2003
    ....
  6. ncbi Reactive nitrogen species in the chemical biology of inflammation
    Peter C Dedon
    Biological Engineering Department, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Arch Biochem Biophys 423:12-22. 2004
    ..Bruce Ames, will focus on recent advances in our understanding of the protein and DNA damage caused by reactive nitrogen species produced by macrophages and neutrophils, with emphasis on nitric oxide, nitrous anhydride, peroxynitrite,..
  7. ncbi Regulation of immune responses by L-arginine metabolism
    Vincenzo Bronte
    Cancer Center of Veneto Region, Department of Oncological and Surgical Sciences, Padua University, Via Gattamelata 64, Padua, Italy
    Nat Rev Immunol 5:641-54. 2005
    ..This Review article focuses on the relevance of L-arginine metabolism by myeloid cells for immunity under physiological and pathological conditions...
  8. ncbi Metabolism of reactive nitrogen species in pea plants under abiotic stress conditions
    Francisco J Corpas
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas, E 18080 Granada, Spain
    Plant Cell Physiol 49:1711-22. 2008
    ..However, little is known about the metabolism of endogenous *NO and other reactive nitrogen species (RNS) in plants under abiotic stress conditions...
  9. ncbi Pro-thrombotic state induced by post-translational modification of fibrinogen by reactive nitrogen species
    Caryn Vadseth
    Stokes Research Institute and Department of Biochemistry and Biophysics, Children s Hospital of Philadelphia, Philadelphia, PA 19104, USA
    J Biol Chem 279:8820-6. 2004
    ..The present results may account, in part, for the association between nitrative stress and risk for coronary artery disease...
  10. ncbi Reactive nitrogen species in the respiratory tract
    Fabio L M Ricciardolo
    Unit of Pneumology, IRCCS Gaslini Institute, Largo G Gaslini 5, 16147 Genoa, Italy
    Eur J Pharmacol 533:240-52. 2006
    ..enzymatic release of NO and augmented NO metabolites produce the formation of strong oxidizing reactive nitrogen species, such as peroxynitrite, in various airway diseases including asthma, chronic obstructive pulmonary ..
  11. ncbi Biological chemistry of reactive oxygen and nitrogen and radiation-induced signal transduction mechanisms
    Ross B Mikkelsen
    Department of Radiation Oncology, Virginia Commonwealth University, 401 College Street, Richmond, VA 23298, USA
    Oncogene 22:5734-54. 2003
    ..For cytoplasmic signaling, radiation-stimulated reactive oxygen species (ROS) and reactive nitrogen species (RNS) are essential activators of these pathways...
  12. pmc Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite
    Joseph H Holthoff
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, Little Rock, AR, USA
    Biochem Pharmacol 80:1260-5. 2010
    Oxidant damage from reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a major contributor to the cellular damage seen in numerous types of renal injury...
  13. ncbi The metabolism of sulindac enhances its scavenging activity against reactive oxygen and nitrogen species
    Eduarda Fernandes
    REQUIMTE, Departamento de Quimica Fisica, Faculde de Farmácia da Universidade do Porto, Porto, Portugal
    Free Radic Biol Med 35:1008-17. 2003
    ..the primary mechanism of action of sulindac, it is well known that reactive oxygen species (ROS) and reactive nitrogen species (RNS) are implicated in the pathophysiology of inflammation and cancer...
  14. pmc Nitrate respiration protects hypoxic Mycobacterium tuberculosis against acid- and reactive nitrogen species stresses
    Mai Ping Tan
    Novartis Institute for Tropical Diseases, Singapore, Singapore
    PLoS ONE 5:e13356. 2010
    ..Overall, these data shed light on a new role for nitrate respiration in protecting M. tuberculosis from acidity and reactive nitrogen species, two environmental stresses likely encountered by the pathogen during the course of infection.
  15. pmc Aging might augment reactive oxygen species (ROS) formation and affect reactive nitrogen species (RNS) level after myocardial ischemia/reperfusion in both humans and rats
    Qian Fan
    Department of Gerontology, Beijing Chaoyang Hospital Affiliate of Beijing Capital Medical University, 8 Gongtinan Road, Beijing, 100020, People s Republic of China
    Age (Dordr) 35:1017-26. 2013
    ..Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are known to play vital roles in aging-related MI/R injury...
  16. pmc Reactive nitrogen species in acetaminophen-induced mitochondrial damage and toxicity in mouse hepatocytes
    Angela S Burke
    Department of Pharmacology and Toxicology College of Medicine, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Chem Res Toxicol 23:1286-92. 2010
    ..Since DCFH(2) may be oxidized by multiple oxidative mechanisms, we investigated the role of reactive nitrogen species (RNS) leading to 3-nitrotyrosine in proteins by ELISA and by immunoblots...
  17. ncbi Nitrosative stress in plants
    Raquel Valderrama
    Grupo de Señalización Molecular y Sistemas Antioxidantes en Plantas, Unidad Asociada al CSIC EEZ, Área de Bioquímica y Biología Molecular, Universidad de Jaen, E 23071 Jaén, Spain
    FEBS Lett 581:453-61. 2007
    ..RSNO or antibodies to S-nitrosoglutathione and 3-nitrotyrosine, showed also a general increase of these reactive nitrogen species (RNS) mainly in the vascular tissue...
  18. ncbi Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1
    Paula Aracena-Parks
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas 77030, USA
    J Biol Chem 281:40354-68. 2006
    ..In summary, we have identified a discrete subset of cysteines that are likely to be involved in the functional response of RyR1 to different redox modifications (S-nitrosylation, S-glutathionylation, and oxidation to disulfides)...
  19. ncbi Nanotransducers in cellular redox signaling: modification of thiols by reactive oxygen and nitrogen species
    Chris E Cooper
    Dept of Biological Sciences, University of Essex, Wivenhoe Park, CO4 3SQ, Colchester, UK
    Trends Biochem Sci 27:489-92. 2002
    ..The findings offer the enticing possibility that the cell can distinguish between different degrees of oxidant and nitrosative exposure by modification at a single site on a signaling molecule...
  20. pmc Age-related changes in skeletal muscle reactive oxygen species generation and adaptive responses to reactive oxygen species
    Malcolm J Jackson
    Institute of Ageing and Chronic Disease, University of Liverpool, Liverpool L69 3GA, UK
    J Physiol 589:2139-45. 2011
    ..This age-related lack of physiological adaptations to the ROS induced by contractile activity appears to contribute to a loss of ROS homeostasis and increased oxidative damage in skeletal muscle...
  21. pmc Oxidative stress mediates through apoptosis the anticancer effect of phospho-nonsteroidal anti-inflammatory drugs: implications for the role of oxidative stress in the action of anticancer agents
    Yu Sun
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, New York, USA
    J Pharmacol Exp Ther 338:775-83. 2011
    ....
  22. ncbi The role of oxidative stress in prostate cancer
    Gaytri Gupta-Elera
    Department of Microbiology and Molecular Biology, Brigham Young University, Provo, UT 84602, USA
    Eur J Cancer Prev 21:155-62. 2012
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are not only byproducts of normal cellular metabolism, but also play important roles in cell signaling...
  23. ncbi Direct oxidative modifications of signalling proteins in mammalian cells and their effects on apoptosis
    K England
    Department of Biochemistry, Biosciences Institute, University College Cork, Cork, Ireland
    Redox Rep 10:237-45. 2005
    ..This review discusses direct oxidative protein modifications and their effects on apoptosis...
  24. pmc RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice
    William J Durham
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX 77030, USA
    Cell 133:53-65. 2008
    ..We demonstrate that this mutation in RyR1 causes Ca(2+) leak, which drives increased generation of reactive nitrogen species (RNS)...
  25. ncbi S-nitrosylation: a potential new paradigm in signal transduction
    Antonio Martínez-Ruiz
    Centro de Investigaciones Biologicas, Consejo Superior de Investiaciones Cientificas and Instituto Reina Sofia de Investigaciones Nefrológicas, Ramiro de Maeztu, 9, Madrid E 28040
    Cardiovasc Res 62:43-52. 2004
    ..years, newer roles have been attributed to this molecule and its close relatives, termed collectively reactive nitrogen species (RNS)...
  26. pmc Myeloperoxidase produces nitrating oxidants in vivo
    Joseph P Gaut
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 109:1311-9. 2002
    Despite intense interest in pathways that generate reactive nitrogen species, the physiologically relevant mechanisms for inflammatory tissue injury remain poorly understood...
  27. pmc Reactive nitrogen species is required for the activation of the AMP-activated protein kinase by statin in vivo
    Hyoung Chul Choi
    Sections of Endocrinology and Nephrology, Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    J Biol Chem 283:20186-97. 2008
    ..Taken together, our data suggest that AMPK activation by statin is peroxynitrite-mediated but PKC-zeta-dependent...
  28. ncbi Positive and negative regulation of insulin signaling by reactive oxygen and nitrogen species
    Nava Bashan
    Department of Clinical Biochemistry, Ben Gurion University of the Negev, Beer Sheva, Israel
    Physiol Rev 89:27-71. 2009
    Regulated production of reactive oxygen species (ROS)/reactive nitrogen species (RNS) adequately balanced by antioxidant systems is a prerequisite for the participation of these active substances in physiological processes, including ..
  29. ncbi Reactive nitroxidative species and nociceptive processing: determining the roles for nitric oxide, superoxide, and peroxynitrite in pain
    Joshua W Little
    Department of Surgery, Center for Anatomical Science and Education, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63104, USA
    Amino Acids 42:75-94. 2012
    ....
  30. ncbi A tale of two controversies: defining both the role of peroxidases in nitrotyrosine formation in vivo using eosinophil peroxidase and myeloperoxidase-deficient mice, and the nature of peroxidase-generated reactive nitrogen species
    Marie Luise Brennan
    Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    J Biol Chem 277:17415-27. 2002
    ..our results demonstrate that: 1) MPO and EPO contribute to tyrosine nitration in vivo; 2) the major reactive nitrogen species formed by leukocyte peroxidase-catalyzed oxidation of NO(2)(-) is the one-electron oxidation product, (*)..
  31. pmc Differential effects of reactive nitrogen species on DNA base excision repair initiated by the alkyladenine DNA glycosylase
    Larry E Jones
    Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29208, USA
    Carcinogenesis 30:2123-9. 2009
    Chronic generation of reactive nitrogen species (RNS) can cause DNA damage and may also directly modify DNA repair proteins...
  32. ncbi Scavenging of reactive nitrogen species by mycobacterial truncated hemoglobins
    Paolo Ascenzi
    National Institute for Infectious Diseases IRCCS Lazzaro Spallanzani, Rome, Italy
    Methods Enzymol 436:317-37. 2008
    ..Here, mechanisms for scavenging of reactive nitrogen species by mycobacterial trHbs are reviewed, and detailed protocols for assessing pseudoenzymatic kinetics are ..
  33. ncbi Peroxisomes as a cellular source of reactive nitrogen species signal molecules
    Luis A del Rio
    Departamento de Bioquimica, Biologia Celular y Molecular de Plantas, Estacion Experimental del Zaidin, Consejo Superior de Investigaciones Cientificas CSIC, Apartado 419, E 18080 Granada, Spain
    Arch Biochem Biophys 506:1-11. 2011
    ..the existence of l-arginine-dependent nitric oxide synthase (NOS) activity and the generation of the reactive nitrogen species (RNS) nitric oxide (NO) have been demonstrated in plant peroxisomes...
  34. ncbi Abiotic oxidation of Fe(II) by reactive nitrogen species in cultures of the nitrate-reducing Fe(II) oxidizer Acidovorax sp. BoFeN1 - questioning the existence of enzymatic Fe(II) oxidation
    N Klueglein
    Geomicrobiology, Center for Applied Geosciences, University of Tubingen, Tubingen, Germany
    Geobiology 11:180-90. 2013
    ....
  35. ncbi Redox proteomics: basic principles and future perspectives for the detection of protein oxidation in plants
    Sara Rinalducci
    Department of Environmental Sciences, University of Tuscia, Largo dell Università snc, I 01100, Viterbo, Italy
    J Exp Bot 59:3781-801. 2008
    ..In this sense, redox proteomics will have a central role in the definition of redox molecular mechanisms associated with cellular stresses...
  36. ncbi Nitric oxide as a mediator for defense responses
    Diana Bellin
    Biotechnology Department, University of Verona, Verona, Italy
    Mol Plant Microbe Interact 26:271-7. 2013
    ..PRR and R proteins modulate signaling networks for defense responses that rely on rapid production of reactive nitrogen species (RNS) and reactive oxygen species (ROS)...
  37. ncbi Functional complementation in yeast reveals a protective role of chloroplast 2-Cys peroxiredoxin against reactive nitrogen species
    Atsushi Sakamoto
    Department of Mathematical and Life Sciences, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashi Hiroshima, Hiroshima 739 8526, Japan
    Plant J 33:841-51. 2003
    ..about how plants protect themselves from nitrosative and oxidative damage mediated by NO and NO-derived reactive nitrogen species (RNS)...
  38. pmc Macrophages, reactive nitrogen species, and lung injury
    Debra L Laskin
    Rutgers University, Piscataway, New Jersey, USA
    Ann N Y Acad Sci 1203:60-5. 2010
    ..Among the mediators involved in the cytotoxic process, reactive nitrogen species (RNS) are of particular interest because of their well-documented cytotoxic potential...
  39. ncbi Shear-induced reactive nitrogen species inhibit mitochondrial respiratory complex activities in cultured vascular endothelial cells
    Zhaosheng Han
    Department of Medicine, The Ohio State University, Columbus, OH 43210, USA
    Am J Physiol Cell Physiol 292:C1103-12. 2007
    There is evidence that nitric oxide (NO), superoxide (O(2)(*-)), and their associated reactive nitrogen species (RNS) produced by vascular endothelial cells (ECs) in response to hemodynamic forces play a role in cell signaling...
  40. pmc Leghemoglobin green derivatives with nitrated hemes evidence production of highly reactive nitrogen species during aging of legume nodules
    Joaquin Navascues
    Departamento de Nutrición Vegetal, Estacion Experimental de Aula Dei, Consejo Superior de Investigaciones Cientificas, 50080 Zaragoza, Spain
    Proc Natl Acad Sci U S A 109:2660-5. 2012
    ..heme ligands reveals that nitration is contingent upon the binding of nitrite to heme Fe, and that the reactive nitrogen species involved derives from nitrous acid and is most probably the nitronium cation...
  41. ncbi Evidence for the role of reactive nitrogen species in polymicrobial sepsis-induced renal peritubular capillary dysfunction and tubular injury
    Liping Wu
    Department of Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 West Markham Street 611, Little Rock, AR 72205, USA
    J Am Soc Nephrol 18:1807-15. 2007
    ..IVVM with dihydrorhodamine-123 was used to quantify in real time reactive nitrogen species (RNS) generation by renal tubules, and the inducible nitric oxide synthase inhibitor L-iminoethyl-lysine ..
  42. ncbi Detection of reactive oxygen and reactive nitrogen species in skeletal muscle
    C L Murrant
    Department of Pharmacology and Physiology, University of Rochester, Rochester, New York 14642, USA
    Microsc Res Tech 55:236-48. 2001
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are usually identified with pathological states and mediators of cellular injury...
  43. ncbi Tronchuda cabbage (Brassica oleracea L. var. costata DC): scavenger of reactive nitrogen species
    Carla Sousa
    REQUIMTE Servico de Farmacognosia, Faculdade de Farmacia, Universidade do Porto, R Anibal Cunha Porto, Portugal
    J Agric Food Chem 56:4205-11. 2008
    The ability of tronchuda cabbage ( Brassica oleracea L. var. costata DC) to act as a scavenger of the reactive nitrogen species nitric oxide and peroxynitrite was investigated...
  44. ncbi Altered levels of seminal nitric oxide, nitric oxide synthase, and enzymatic antioxidants and their association with sperm function in infertile subjects
    T Ramya
    Department of Reproductive Biomedicine, National Institute of Health and Family Welfare, New Delhi, India
    Fertil Steril 95:135-40. 2011
    To investigate the association between specific reactive nitrogen species and sperm function among infertile subjects.
  45. pmc DNA damage and reactive nitrogen species are barriers to Vibrio cholerae colonization of the infant mouse intestine
    Bryan W Davies
    Department of Microbiology and Molecular Genetics, Harvard Medical School, Boston, Massachusetts, USA
    PLoS Pathog 7:e1001295. 2011
    ..Our genetic analysis identifies known and novel defense enzymes required for detoxifying reactive nitrogen species (but not reactive oxygen species) that are also required for V...
  46. ncbi Modulation of human T-cell functions by reactive nitrogen species
    Tihana Kasic
    Venetian Institute of Molecular Medicine, Padua, Italy
    Eur J Immunol 41:1843-9. 2011
    ..have suggested that T-lymphocyte dysfunction might be attributable to nitrative stress induced by reactive nitrogen species (RNS)...
  47. pmc Prominent roles of the NorR and Fur regulators in the Escherichia coli transcriptional response to reactive nitrogen species
    Partha Mukhopadhyay
    Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Proc Natl Acad Sci U S A 101:745-50. 2004
    ..eutrophus, and Fur, the global repressor of ferric ion uptake, are major regulators of the response to reactive nitrogen species. In contrast, SoxR and OxyR, regulators of the E...
  48. ncbi Involvement of reactive oxygen species and reactive nitrogen species in the wound response of Dasycladus vermicularis
    Cliff Ross
    Smithsonian Marine Station at Fort Pierce, 701 Seaway Drive, Fort Pierce, Florida 34949, USA
    Chem Biol 13:353-64. 2006
    ..Based on the use of selected pharmacological probes, our results indicate that H2O2 production involves the upstream activation of signaling events similar to those observed in the physiology of higher plants...
  49. ncbi Reactive nitrogen species: molecular mechanisms and potential significance in health and disease
    M Carmen Martinez
    INSERM, U771, CNRS UMR, 6214, and Université d Angers, Angers, France
    Antioxid Redox Signal 11:669-702. 2009
    b>Reactive nitrogen species (RNS) are various nitric oxide-derived compounds, including nitroxyl anion, nitrosonium cation, higher oxides of nitrogen, S-nitrosothiols, and dinitrosyl iron complexes...
  50. ncbi Reactive nitrogen species augment fibroblast-mediated collagen gel contraction, mediator production, and chemotaxis
    Hisatoshi Sugiura
    University of Nebraska Medical Center, 985885 Nebraska Medical Center, Omaha, NE 68198 5885, USA
    Am J Respir Cell Mol Biol 34:592-9. 2006
    b>Reactive nitrogen species (RNS) such as peroxynitrite cause cellular injury and tissue inflammation...
  51. ncbi Reactive nitrogen species switch on early extracellular matrix remodeling via induction of MMP1 and TNFalpha
    Raquel Urtasun
    Department of Medicine, Division of Liver Diseases, Mount Sinai School of Medicine, New York, New York 10029, USA
    Gastroenterology 136:1410-22, e1-4. 2009
    ..Liver injury leads to generation of reactive oxygen and nitrogen species, which can react to produce peroxynitrite (ONOO-). We investigated whether ONOO- and its metabolites modulate extracellular matrix remodeling...
  52. pmc Regulation of Ras proteins by reactive nitrogen species
    Michael F Davis
    Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
    Free Radic Biol Med 51:565-75. 2011
    ..Since the mid-1990s, however, evidence has accumulated that small molecule reactive nitrogen species (RNS) can also influence Ras guanine nucleotide cycling...
  53. ncbi Hyperglycemia induces apoptosis of pancreatic islet endothelial cells via reactive nitrogen species-mediated Jun N-terminal kinase activation
    Lei Gong
    Department of Endocrinology, Shandong University, Jinan, Shandong, People s Republic of China
    Biochim Biophys Acta 1813:1211-9. 2011
    ..Moreover, induced reactive nitrogen species (RNS) significantly increased the expression of bax, cleaved caspase-3 and poly adenosine diphosphate (..
  54. ncbi Aging and the role of reactive nitrogen species
    Barry Drew
    Biochemistry of Aging Laboratory, Box 118206, College of Health and Human Performance, College of Medicine, Center for Exercise Science, University of Florida, Gainesville, Florida 32611, USA
    Ann N Y Acad Sci 959:66-81. 2002
    ..More recently, the role of reactive nitrogen species, such as nitric oxide and its by-products--nitrate (NO3-), nitrite (NO2-), peroxynitrite (ONOO-), and 3-..
  55. ncbi 8-nitroguanine, a product of nitrative DNA damage caused by reactive nitrogen species: formation, occurrence, and implications in inflammation and carcinogenesis
    Hiroshi Ohshima
    International Agency for Research on Cancer, Lyon, France
    Antioxid Redox Signal 8:1033-45. 2006
    ..formed by reactions of guanine, guanosine, and 2 - deoxyguanosine, either free or in DNA or RNAwith reactive nitrogen species (RNS) generated from peroxynitrite, the myeloperoxidase-H(2)O(2)-nitrite system, and others...
  56. ncbi Role of antioxidants in redox regulation of diabetic cardiovascular complications
    Belma Turan
    Department of Biophysics, Faculty of Medicine, Ankara University, Ankara, Turkey
    Curr Pharm Biotechnol 11:819-36. 2010
    ..In addition, we discuss studies identify redox-sensitive cardiac proteins, as well as those assessing redox signalling in cardiovascular disease...
  57. ncbi The role of oxidative stress in carcinogenesis
    James E Klaunig
    Department of Pharmacology and Toxicology, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Annu Rev Pharmacol Toxicol 44:239-67. 2004
    ..This review examines the evidence of cellular oxidants' involvement in the carcinogenesis process, and focuses on the mechanisms for production, cellular damage produced, and the role of signaling cascades by reactive oxygen species...
  58. pmc Kinetic analysis of intracellular concentrations of reactive nitrogen species
    Chang Hoon Lim
    Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
    Chem Res Toxicol 21:2134-47. 2008
    b>Reactive nitrogen species derived from NO have been implicated in cancer and other diseases, but their intracellular concentrations are largely unknown...
  59. ncbi Epr analysis reveals three tissues responding to endotoxin by increased formation of reactive oxygen and nitrogen species
    Andrey V Kozlov
    Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria
    Free Radic Biol Med 34:1555-62. 2003
    ..In summary, low-temperature EPR combined with CP-H infusion allowed detection of local RONS formation in tissues. Increased formation of RONS in response to endotoxin challenge is organ specific...
  60. ncbi Acetoaminophen-induced accumulation of 8-oxodeoxyguanosine through reduction of Ogg1 DNA repair enzyme in C6 glioma cells
    Jie Wan
    Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism NIH, 12420 Parklawn Drive, Rockville, MD 20852, USA
    Exp Mol Med 36:71-7. 2004
    ..These results indicate that APAP in large doses can increase the 8-oxodG level partly through significant reduction of Ogg1 DNA repair enzyme...
  61. pmc Chloroplasts as a nitric oxide cellular source. Effect of reactive nitrogen species on chloroplastic lipids and proteins
    Sebastián Jasid
    Physical Chemistry PRALIB, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Plant Physiol 142:1246-55. 2006
    ..Data reported here suggest that NO is an endogenous metabolite in soybean chloroplasts and that reactive nitrogen species could exert either antioxidant or prooxidant effects on chloroplast macromolecules.
  62. ncbi Chronic inflammation and oxidative stress in human carcinogenesis
    Alessandro Federico
    Division of Gastroenterology, F Magrassi and A Lanzara Medical Surgical Department, Second University of Naples, Naples, Italy
    Int J Cancer 121:2381-6. 2007
    ..This review focalizes some of these intricate events by discussing the relationships occurring among oxidative/nitrosative/metabolic stress, inflammation and cancer...
  63. ncbi Development of enzymatic probes of oxidative and nitrosative DNA damage caused by reactive nitrogen species
    Min Dong
    Biological Engineering Division NE47 277, Massachusetts Institute of Technology, Cambridge, MA 02139, USA
    Mutat Res 594:120-34. 2006
    ....
  64. pmc Targeting reactive nitrogen species: a promising therapeutic strategy for cerebral ischemia-reperfusion injury
    Xing miao Chen
    School of Chinese Medicine, Research Centre of Heart, Brain, Hormone and Healthy Aging, The University of Hong Kong, Hong Kong SAR, China
    Acta Pharmacol Sin 34:67-77. 2013
    ..As an important component of free radicals, reactive nitrogen species (RNS), including nitric oxide (NO) and peroxynitrite (ONOO(-)), play important roles in the process of ..
  65. ncbi Reactive nitrogen species mediate DNA damage in Helicobacter pylori-infected gastric mucosa
    Masaki Katsurahara
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biochemical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Helicobacter 14:552-8. 2009
    Reactive oxygen species (ROS) and reactive nitrogen species (RNS) can play an important role in cellular injury and carcinogenesis of gastric epithelial cells infected with Helicobacter pylori...
  66. ncbi Interaction of dicaffeoylquinic derivatives with peroxynitrite and other reactive nitrogen species
    Ana Olmos
    Departament de Farmacologia, Facultat de Farmacia, Universitat de Valencia, Av Vicent Andres Estelles s n, 46100 Burjassot, Spain
    Arch Biochem Biophys 475:66-71. 2008
    ..among them catechins and hydroxycinnamoyl conjugates, constitute a well defined class of inhibitors of reactive nitrogen species (RNS)...
  67. ncbi Xanthine oxidase inhibition reduces reactive nitrogen species production in COPD airways
    M Ichinose
    Third Dept of Internal Medicine, Wakayama Medical University, Wakayama, Japan
    Eur Respir J 22:457-61. 2003
    b>Reactive nitrogen species (RNS) have been reported to be involved in the inflammatory process in chronic obstructive pulmonary disease (COPD). However, there are no studies on the modulation of RNS in COPD...
  68. ncbi Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression
    Ning Ma
    Department of Anatomy, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Int J Cancer 122:2517-25. 2008
    ..These data suggest that nuclear accumulation of EGFR and STAT3 activation by IL-6 play the key role in iNOS expression and resultant DNA damage, leading to EBV-mediated NPC...
  69. ncbi Anti-inflammatory activities of cucurbitacin E isolated from Citrullus lanatus var. citroides: role of reactive nitrogen species and cyclooxygenase enzyme inhibition
    Siddig Ibrahim Abdelwahab
    Department of Pharmacy, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia
    Fitoterapia 82:1190-7. 2011
    ..ORAC and FRAP assays showed that CE is not a potent ROS scavenger. It could be concluded that CE is potentially useful in treating inflammation through the inhibition of COX and RNS but not ROS...
  70. ncbi Critical role of reactive nitrogen species in lung ischemia-reperfusion injury
    Babu V Naidu
    Department of Surgery, University of Washington, Seattle, Washington 98195, USA
    J Heart Lung Transplant 22:784-93. 2003
    ..The purpose of the study was to examine the role of this reactive nitrogen species in lung ischemia-reperfusion injury.
  71. ncbi Reactive nitrogen species induce nuclear factor-kappaB-mediated protein degradation in skeletal muscle cells
    Marina Bar-Shai
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, P O Box 9649, Haifa 31096, Israel
    Free Radic Biol Med 40:2112-25. 2006
    ..Recently, a role for NF-kappaB in upregulation of proteolytic systems and protein degradation has emerged. Reactive nitrogen species (RNS) have been demonstrated to induce NF-kappaB activation...
  72. pmc Cross-linking of serine racemase dimer by reactive oxygen species and reactive nitrogen species
    Wei Wang
    Department of Geriatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    J Neurosci Res 90:1218-29. 2012
    ..These findings suggest a compensatory feedback in which the consequences of neuroinflammation might dampen D-serine production to limit excitotoxic stimulation of NMDA receptors...
  73. ncbi Nitric oxide, reactive nitrogen species and associated enzymes during plant senescence
    Dagmar Prochazkova
    Institute of Experimental Botany, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Nitric Oxide 24:61-5. 2011
    ..However, very little is known about other radicals: gaseous free radical nitric oxide and related molecules--reactive nitrogen species. This review brings a short survey of the questions.
  74. ncbi Free radicals, mitochondria, and oxidized lipids: the emerging role in signal transduction in vascular cells
    Jessica Gutierrez
    Department of Physiology and Biophysics, Center for Free Radical Biology, University of Alabama at Birmingham, USA
    Circ Res 99:924-32. 2006
    ..In this review, we describe recent evidence that supports the hypothesis that mitochondria have an important role in cell signaling, and so contribute to both the adaptation to oxidative stress and the development of vascular diseases...
  75. ncbi High concentrations and dry deposition of reactive nitrogen species at two sites in the North China Plain
    J L Shen
    College of Resources and Environmental Sciences, Key Lab of Plant Soil Interactions MOE, China Agricultural University, Beijing, China
    Environ Pollut 157:3106-13. 2009
    ..Such high concentrations and deposition rates of N(r) species in the NCP indicate very serious air pollution from anthropogenic sources and significant atmospheric N input to crops...
  76. ncbi Kinetics and mechanistic studies of the reactions of metleghemoglobin, ferrylleghemoglobin, and nitrosylleghemoglobin with reactive nitrogen species
    Susanna Herold
    Laboratorium für Anorganische Chemie, Eidgenossische Technische Hochschule, ETH Honggerberg, 8093, Zurich, Switzerland
    J Biol Inorg Chem 10:946-57. 2005
    ..but also with so-called reactive nitrogen species derived from it, among others peroxynitrite and nitrite...
  77. ncbi Reactive nitrogen species induced by hyperglycemia suppresses Akt signaling and triggers apoptosis by upregulating phosphatase PTEN (phosphatase and tensin homologue deleted on chromosome 10) in an LKB1-dependent manner
    Ping Song
    Section of Endocrinology and Diabetes, Department of Medicine, University of Oklahoma Health Science Center, Oklahoma City, OK 73104, USA
    Circulation 116:1585-95. 2007
    ..Oxidative stress plays a causal role in vascular injury in diabetes mellitus, but the mechanisms and targets remain poorly understood...
  78. ncbi Modification of tryptophan and tryptophan residues in proteins by reactive nitrogen species
    Fumiyuki Yamakura
    Department of Chemistry, Juntendo University School of Medicine, 1 1 Hiragagakuendai, Inba, Chiba 270 1606, Japan
    Nitric Oxide 14:152-61. 2006
    Formation of 3-nitrotyrosine by the reaction between reactive nitrogen species (RNS) and tyrosine residues in proteins has been analyzed extensively and it is used widely as a biomarker of pathophysiological and physiological conditions ..
  79. ncbi Microcapsules containing antioxidant molecules as scavengers of reactive oxygen and nitrogen species
    Eliseu Rodrigues
    Department of Food Science, School of Food Engineering, University of Campinas UNICAMP, Rua Monteiro Lobato, 80, 13083 862 Campinas, Brazil
    Food Chem 134:704-11. 2012
    ....
  80. ncbi Glycated high-density lipoprotein regulates reactive oxygen species and reactive nitrogen species in endothelial cells
    Toshiyuki Matsunaga
    Department of Biochemistry, Saitama Medical School, Moroyama, Saitama, Japan
    Metabolism 52:42-9. 2003
    ..Taking all of the above findings together, gly-ox-HDL may lead to the deterioration of vascular function through altered production of reactive oxygen species and reactive nitrogen species in endothelial cells.
  81. ncbi Nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species
    Phillip J White
    The Quebec Heart and Lung Institute, Hopital Laval, Quebec, Canada G1V 4G5
    Am J Physiol Endocrinol Metab 299:E868-78. 2010
    ..present review on the effects of nitrosative modifications of protein and lipid signaling molecules by reactive nitrogen species. The aim of this Perspectives review is to highlight the significant role that reactive nitrogen species ..
  82. ncbi Inhibition of apoptosis in human retinal pigment epithelial cells treated with benzo(e)pyrene, a toxic component of cigarette smoke
    Saffar Mansoor
    Department of Ophthalmology, School of Medicine, University of California, Irvine, CA 92868, USA
    Invest Ophthalmol Vis Sci 51:2601-7. 2010
    ..To study the inhibitory effects of some agents or drugs (inhibitors) on benzo(e)pyrene (B(e)P)-induced cell death and apoptosis on human retinal pigment epithelial (ARPE-19) cells in vitro...
  83. ncbi Lutein, zeaxanthin and astaxanthin protect against DNA damage in SK-N-SH human neuroblastoma cells induced by reactive nitrogen species
    Marcello Santocono
    Medical Department, SIFI SpA, Via E Patti 36, Lavinaio CT, Italy
    J Photochem Photobiol B 88:1-10. 2007
    ..The data from this study provides additional information on the activities of the macular pigment carotenoids of the human retina...
  84. ncbi Role of reactive nitrogen species in blood platelet functions
    Beata Olas
    Department of General Biochemistry, Institute of Biochemistry, University of Łódź, Banacha 12 16, 90 237 Łódź, Poland
    Platelets 18:555-65. 2007
    ..This review describes the chemical structure and biological activities of reactive nitrogen species, mainly nitric oxide ((*)NO) and peroxynitrite (ONOO(-)) and their effects on blood platelet functions, ..
  85. pmc Differential sensitivity of oligodendrocytes and motor neurons to reactive nitrogen species: implications for multiple sclerosis
    Amy Bishop
    Department of Biological Sciences, University of Alabama in Huntsville, Huntsville, Alabama 35899, USA
    J Neurochem 109:93-104. 2009
    ..Preliminary studies suggest oligodendrocytes release a soluble factor that protects motor neurons. Our findings challenge the current paradigm that oligodendrocytes are the exclusive target of multiple sclerosis pathology...
  86. ncbi S-thiolation of tyrosine hydroxylase by reactive nitrogen species in the presence of cysteine or glutathione
    Mahdieh Sadidi
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Antioxid Redox Signal 7:863-9. 2005
    ..which are known to S-thiolate proteins, can be formed in the reaction of cysteine or glutathione with reactive nitrogen species. Therefore, S-nitrosoglutathione (GSNO) was tested for its ability to modify TH...
  87. ncbi Reactive nitrogen species derived activation of rat liver microsomal glutathione S-transferase
    Naoki Imaizumi
    Laboratory of Functional and Molecular Pharmacology, Graduate School of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903 0215, Japan
    Life Sci 78:2998-3006. 2006
    The effect of reactive nitrogen species on rat liver microsomal glutathione S-transferase (MGST1) was investigated using microsomes and purified MGST1...
  88. ncbi Release of nitrite from the antitubercular nitroimidazole drug PA-824 and analogues upon one-electron reduction in protic, non-aqueous solvent
    Andrej Maroz
    Department of Chemistry, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
    Org Biomol Chem 8:413-8. 2010
    ..The release of cytotoxic reactive nitrogen species through a one-electron pathway, by as yet unidentified proteins, may play a role in the activity of this ..
  89. ncbi Role of iNOS-derived reactive nitrogen species and resultant nitrative stress in leukocytes-induced cardiomyocyte apoptosis after myocardial ischemia/reperfusion
    Xiao liang Wang
    Department of Physiology, Shanxi Medical University, 56 South Xinjian Road, Taiyuan, Shanxi, 030001, P R China
    Apoptosis 12:1209-17. 2007
    ..studies have demonstrated that PMNs express inducible nitric oxide synthase (iNOS) and produce toxic reactive nitrogen species (RNS)...
  90. pmc deltaPKC inhibition or varepsilonPKC activation repairs endothelial vascular dysfunction by regulating eNOS post-translational modification
    Martina Monti
    Department of Molecular Biology, University of Siena, Via Aldo Moro, 2, 53100, Siena, Italy
    J Mol Cell Cardiol 48:746-56. 2010
    ..Together our data demonstrate that (1) in endothelial dysfunction, ROS and reactive nitrogen species (RNS) formation result from uncontrolled eNOS activity mediated by activation of deltaPKC or inhibition ..
  91. ncbi Effects of cigarette smoke borne reactive nitrogen species on salivary alpha-amylase activity and protein modifications
    D Weiner
    Department of Anatomy and Cell Biology, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel
    J Physiol Pharmacol 60:127-32. 2009
    ..All salivary reactive nitrogen species (RNS) analyzed from OSCC patients are significantly higher in comparison with healthy subjects...
  92. ncbi The oxidative response in the chronic constriction injury model of neuropathic pain
    Edward C T H Tan
    Department of General Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Surg Res 152:84-8. 2009
    ..We, therefore, investigated the level of oxidative stress and antioxidant enzymes in skeletal muscle tissue of the rat hind paw and (jugular vein) plasma at d 7 after nerve injury...
  93. ncbi Mechanisms underlying cigarette smoke-induced NF-kappaB activation in human lymphocytes: the role of reactive nitrogen species
    E Hasnis
    Department of Anatomy and Cell Biology, Rappaport Faculty of Medicine, Technion Israel Institute of Technology, Haifa, Israel
    J Physiol Pharmacol 58:275-87. 2007
    Cigarette smoke (CS) is an important source of reactive nitrogen species (RNS). It has been demonstrated that CS constitutes the highest source of exogenous nitric oxide and peroxynitrite to which humans are exposed...
  94. ncbi [Role of free radicals and reactive nitrogen species in the late complications of diabetes mellitus in rats]
    Krisztian Stadler
    Magyar Tudományos Akadémia Kémiai Kutatóközpont Kémiai Intézet, Biooxidációs csoport, Budapest
    Orv Hetil 145:1135-40. 2004
    ....
  95. ncbi The role of the flavodiiron proteins in microbial nitric oxide detoxification
    Lígia M Saraiva
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Apartado 127 Avenida da República EAN, 2781 901 Oeiras, Portugal
    Adv Microb Physiol 49:77-129. 2004
    ....
  96. ncbi Reactive nitrogen species contribute to blood-labyrinth barrier disruption in suppurative labyrinthitis complicating experimental pneumococcal meningitis in the rat
    S Kastenbauer
    Department of Neurology, Klinikum Grossetahadern, Ludwig-Maximilians University, Munich, Germany
    Brain Res 904:208-17. 2001
    ..There is a substantial body of evidence that oxidants, such as reactive nitrogen species (RNS), are central mediators of brain damage in experimental bacterial meningitis...
  97. ncbi Bilirubin: an endogenous scavenger of nitric oxide and reactive nitrogen species
    Cesare Mancuso
    Institute of Pharmacology, Catholic University School of Medicine, Rome, Italy
    Redox Rep 11:207-13. 2006
    ..compelling evidence has shown that BR can serve as an endogenous scavenger of both nitric oxide and reactive nitrogen species, thus widening the protective role of bilirubin to other reactive species originating within the ..
  98. ncbi Production of reactive oxygen species and reactive nitrogen species by angiosperm stigmas and pollen: potential signalling crosstalk?
    Stephanie M McInnis
    School of Biological Sciences, University of Bristol, Woodland Road, Bristol BS8 1UG, UK
    New Phytol 172:221-8. 2006
    ..Constitutive accumulation of ROS/H2O2 appears to be a feature of angiosperm stigmas. This novel finding is discussed in terms of a possible role for stigmatic ROS/H2O2 and pollen-derived NO in pollen-stigma interactions and defence...
  99. pmc Identification of Histoplasma capsulatum transcripts induced in response to reactive nitrogen species
    M Paige Nittler
    Department of Microbiology and Immunology, University of California San Francisco, San Francisco, CA 94143 0414, USA
    Mol Biol Cell 16:4792-813. 2005
    ..can establish persistent infections, indicating that it survives in the host despite exposure to reactive nitrogen species (RNS). To understand how H. capsulatum responds to RNS, we determined the transcriptional profile of H...
  100. pmc Induction of oxidative stress as a mechanism of action of chemopreventive agents against cancer
    B Rigas
    Division of Cancer Prevention, Department of Medicine, Stony Brook University, Stony Brook, NY 11794 5200, USA
    Br J Cancer 98:1157-60. 2008
    ..We conclude that modulation of redox biochemistry represents a fruitful approach to cancer prevention...
  101. ncbi All stressed out. Salmonella pathogenesis and reactive nitrogen species
    K Prior
    School of Biological Sciences, University of East Anglia, Norwich, UK
    Adv Microb Physiol 56:1-28. 2009
    ..and the host during the infection process, with particular emphasis on the complex bacterial response to reactive nitrogen species produced by the host...

Research Grants64

  1. Analysis of gene regulation of Vibrio cholerae during infection
    Jun Zhu; Fiscal Year: 2013
    ..Next we will examine how AphB is modified by reactive nitrogen species (RNS), such as nitric oxide (NO), and oxidative stress from reactive oxygen species (ROS) generated in ..
  2. Ionic currents in gastrointestinal smooth muscle
    Hamid I Akbarali; Fiscal Year: 2013
    ..In this proposal, we will test the hypothesis that reactive nitrogen species produced during colonic inflammation cause nitration of the tyrosine residues within the c-terminus of ..
  3. Novel Therapeutic Targets in Necrotizing Enterocolitis
    Peter J Giannone; Fiscal Year: 2012
    ..NO dysregulation can lead to reactive nitrogen species, leading to cellular protein oxidation and DNA damage...
  4. Dietary Scavenging of Reactive Species in Lung Injury: Role of Macrophages
    THEA NOREEN GOLDEN; Fiscal Year: 2013
    ..activity of oxidant producing enzymes, leads to pathologic conversion of bioactive NO into oxidized reactive nitrogen species. Previous work has identified inhibition of iNOS as a potential target of therapy in several respiratory ..
  5. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK SARKAR; Fiscal Year: 2009
    ..To test this hypothesis we will determine whether highly reactive oxygen species and reactive nitrogen species generated extracellularly and intracellularly by various processes initiate and promote ethanol-induced ..
  6. ROLE OF OPIATES IN ALCOHOL-INDUCED NEUROTOXICITY
    DIPAK KUMAR SARKAR; Fiscal Year: 2013
    ..To test this hypothesis we will determine whether highly reactive oxygen species and reactive nitrogen species generated extracellularly and intracellularly by various processes initiate and promote ethanol-induced ..
  7. SPLENIC TOXICITY OF ANILINE
    M Firoze Khan; Fiscal Year: 2010
    ..Aim 3 will investigate the contribution of reactive nitrogen species to splenic damage by characterizing iNOS regulation and the formation of nitrated proteins, and by ..
  8. Regulations of DNA Alkylation/Deamination Damage Repair
    Rabindra Roy; Fiscal Year: 2013
    Abstract Reactive nitrogen species, alkylating agents and lipid peroxide radicals generated endogenously and exogenously induce a myriad of DNA lesions, which is thought to affect genomic stability, cellular viability and cause multiple ..
  9. Angiotensin-induced Oxidants and Vascular Cell Phenotype
    Richard Cohen; Fiscal Year: 2009
    ..A long-range goal of our group is to understand how reactive oxygen (ROS) and reactive nitrogen species (RNS) derived from NADPH oxidase and nitric oxide synthase(s) regulate the outcome of the vascular cell ..
  10. Protective Effects of Cannabinoids in HIV Neuropathogenesis
    ROBERT BRYAN ROCK; Fiscal Year: 2012
    ..When stimulated by interleukin (IL)-12, astrocytes produce neurotoxic reactive nitrogen species and chemokines, such as CCL2 and CX3CL1, which may recruit macrophages/microglia to the striatum...
  11. Gonococcal resistance to peroxynitrite
    Virginia L Clark; Fiscal Year: 2010
    ..We have determined that N. gonorrhoeae displays remarkable resistance to killing by reactive nitrogen species (RNS), especially peroxynitrite, and we propose that this characteristic allows this organism to escape ..
  12. Microanalytical methods for the detection of reactive nitrogen species
    Susan M Lunte; Fiscal Year: 2010
    ..that will enable researchers to obtain quantitative information regarding the concentration of reactive nitrogen species generated by the cells that make up the neurovascular space...
  13. Redox Determinants of Severe Asthma
    Serpil C Erzurum; Fiscal Year: 2010
    ..of nitric oxide (NO) metabolism with loss of beneficial S-nitrosothiols and formation of cytotoxic reactive nitrogen species. Here, we hypothesize that the pathophysiology of severe asthma is related to abnormalities of enzymes ..
  14. ASS, NOS2, AND ALCOHOLIC LIVER DISEASE
    Natalia Nieto; Fiscal Year: 2012
    ..nitric oxide synthase (NOS2) leading to excessive generation of reactive oxygen species (ROS) and reactive nitrogen species affecting cell survival...
  15. Oxidative Stress and Autoimmunity
    M Firoze Khan; Fiscal Year: 2013
    ..Our long-term goal is to elucidate the role of lipid peroxidation-derived aldehydes (LPDAs) and reactive nitrogen species (RNS) in the development of ADs induced and/or exacerbated by chemical exposure...
  16. Mitochondrial DNA Repair and Biogenesis
    Raquel R Bartz; Fiscal Year: 2013
    ..and for mitochondrial biogenesis given that sepsis leads to mtDNA damage by reactive oxygen species and reactive nitrogen species. If this mtDNA damage from sepsis exceeds the cell's ability to repair damaged mtDNA, fewer ..
  17. Oxidative stress in regional cerebral blood flow alterations after cardiac arrest
    Mioara D Manole; Fiscal Year: 2012
    ..neuropathological damage and (ii) quantify production of nitric oxide, reactive oxygen species and other reactive nitrogen species after two durations of asphyxial cardiac arrest (8.5 min and 12 min)...
  18. Mycobacterium turberculosis metal transport P-type ATPases
    JOSE M ARGUELLO; Fiscal Year: 2010
    ..Host defense includes reactive oxygen species, reactive nitrogen species, removal of metal micronutrients and lowered pH...
  19. BIOINORGANIC COPPER COORDINATION CHEMISTRY
    Kenneth D Karlin; Fiscal Year: 2013
    ..following a new paradigm concerning the possible role of copper ion in the biological formation of the reactive nitrogen species peroxynitrite (-OON=O)...
  20. Redox Regulation of p21ras in Angiogenesis
    Richard A Cohen; Fiscal Year: 2013
    ..Amongst other redox-sensitive proteins, we found that S-glutathiolation of p21ras cysteine-118 (C118) by reactive nitrogen species (RNS), including 7NO and low concentrations of peroxynitrite (OONO-), acutely increases its GTPase ..
  21. Mechanisms of Hypothermic Protection from Ischemia/Reperfusion Cardiac Injury
    Kimm J Hamann; Fiscal Year: 2010
    ..We hypothesize that intra-ischemic hypothermic protection involves the generation of an altered ROS and reactive nitrogen species (RNS) profile, allowing recovery of ischemia-reduced mitochondrial membrane potential and blocking the ..
  22. Role of peroxynitrite in morphine hyperalgesia and tolerance
    Daniela Salvemini; Fiscal Year: 2012
    ..and nitric oxide (.NO), is a potent pro-inflammatory and pro- apoptotic reactive nitrogen species now implicated in hyperalgesia...
  23. Radical Intermediates of Nitric Oxide Synthase &Myocardial Ischemia Reperfusion
    Ah Lim Tsai; Fiscal Year: 2013
    ..and cofactor binding could transform NO synthase to catalyst for the reactive oxygen species (ROS) or reactive nitrogen species (RNS) that are important intermediates for cardiac pathophysiology...
  24. Effect of sarcolemmal KATP channels on ROS/RNS generation and calcium handling
    Richard J Gumina; Fiscal Year: 2013
    ..examining specifically the effect on calcium handling and the generation of reactive oxygen species and reactive nitrogen species using physiological, biochemical, molecular and EPR techniques that are uniquely available within the ..
  25. Endothelial Myocyte Matrix in Cardiac Remodeling
    Suresh C Tyagi; Fiscal Year: 2013
    ..the oxidative and proteolytic stresses induce PAR-1, leading to generate mitochondrial (mt) ROS and reactive nitrogen species (RNS) and mitochondrial nitric oxide synthase (mtNOS), respectively, thus activating the latent resident ..
  26. Aminergic Function in Brain Aging and Alzheimer's Disease
    Paula C Bickford; Fiscal Year: 2010
    ..There are 2 major sources of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the brain and these are from the glia (primarily the microglia) and the mitochondrion...
  27. Targeted fluorescent indicators for endothelial physiology: Ca(II), ROS, NO
    Alan S Waggoner; Fiscal Year: 2013
    ..targeting, these new biosensors will allow detection of Ca(II), reactive oxygen species (ROS), and reactive nitrogen species (RNS) in specific cells, at specific subcellular locations...
  28. Etiology of microvascular changes in Gram-positive sepsis: mechanisms and therape
    Perenlei Enkhbaatar; Fiscal Year: 2013
    ..We propose to elucidate the downstream mechanisms, focusing on the interaction between V1aR, V2R, reactive nitrogen species (RNS), and potent angiogenic growth factors such as angiopoietin-2 (Ang-2) and vascular endothelial ..
  29. Perinatal white matter development and fetal hypoxia
    Sidhartha Tan; Fiscal Year: 2010
    ..We have previously shown that reactive oxygen (ROS) and reactive nitrogen species (RNS) are produced in fetal brain after H-l in this model, and administration of antioxidants to the ..
  30. Regulation of CYP proteins by reactive nitrogen species
    Edward T Morgan; Fiscal Year: 2012
    ..This project will help us to understand what causes this change, and so allow us to predict what patients will need to have their drug doses adjusted to avoid this problem. ..
  31. MCPIP, a novel transcription factor in the development of heart failure
    Pappachan Kolattukudy; Fiscal Year: 2009
    ..We postulate that MCPIP cause production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) that cause ER stress...
  32. Mouse Models for Alcohol Metabolism and Tissue Injury
    Vasilis Vasiliou; Fiscal Year: 2013
    ..Ethanol metabolism by microsomal and mitochondrial systems generates reactive oxygen species and reactive nitrogen species, and is associated with diminished glutathione (GSH) and antioxidant enzymatic activity...
  33. Preclinical evaluation of resveratrol in sepsis-induced renal injury
    JOSEPH HUNTER HOLTHOFF; Fiscal Year: 2013
    ..peritubular microenvironment, which favors the generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  34. Mechanistic targets for intervention in sepsis-induced renal injury
    Philip R Mayeux; Fiscal Year: 2012
    ..This unexpected and novel finding of a CLP-induced vascular defect mediated by reactive nitrogen species (RNS), caspases, and p53 is the basis of our central hypothesis that in sepsis, RNS-initiated activation ..
  35. GSTP1 PROMOTER HYPERMETHYLATION IN HUMAN PROSTATE CANCER
    WILLIAM GEORGE NELSON; Fiscal Year: 2012
    ..Provocative preliminary data hint that reactive nitrogen species, elaborated by inflammatory cells, may drive DNA methylation by a direct effect on DNA methyltransferase ..
  36. A Mechanistic Study of Methamphetamine Neurotoxicity: Involvement of HO-1 & MnSO
    MELINDA LEA ASBURY; Fiscal Year: 2010
    ..involved in MA-induced neurotoxicity, in particular the contribution of heme oxygenase-1 (HO-1), reactive nitrogen species (RNS) and manganese superoxide dismutase (MnSOD)...
  37. Prolonged Diabetic Damage to Cardiac Mitochondria
    Paul N Epstein; Fiscal Year: 2010
    ..to mitochondrial DNA caused by increased mitochondrial generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS)...
  38. Reactive nitrogen species and accelerated atherosclerosis in type I diabetes
    Ming Hui Zou; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): During last funding period, we have found that reactive nitrogen species such as peroxynitrite (ONOO-) uncouples endothelial nitric oxide synthase (eNOS) {generates superoxide anions (O2...
  39. Role of Nitric Oxide in Radiation-Induced Lung Injury
    Rama Malaviya; Fiscal Year: 2013
    ..is to elucidate inflammatory mechanisms mediating lung disease with a particular emphasis on the role of reactive nitrogen species (RONS) in disease pathogenesis...
  40. Sulfur stress in Salmonella enterica
    Lawrence J Reitzer; Fiscal Year: 2010
    ..Evidence will be sought for the possibility that RSS are synergistic with reactive nitrogen species, which could account for the virulence of some pathogens...
  41. Nitrosative Stress in Bacteria: Molecular Targets and Mechanisms of Resistance
    Jonathan S Stamler; Fiscal Year: 2011
    ..reactive oxygen species, such as H2O2 and O2 -, have been extensively studied, the mechanisms by which reactive nitrogen species (e.g. nitric oxide and S-nitrosothiols) kill microbes are relatively unexplored...
  42. Duox2 Modulation of Viral Infection in Airway Epithelium
    Richart W Harper; Fiscal Year: 2012
    ..tract epithelium: When activated by RV, DUOX2 produces hydrogen peroxide (H2O2), hypohalous acid, or reactive nitrogen species to (a) directly inactivate rhinovirus and (b) stimulate the expression of early antiviral genes, but (c) ..
  43. DRUG ABUSE AND REGULATORY ENZYMES OF BIOGENIC AMINES
    ANNETTE FLECKENSTEIN; Fiscal Year: 2010
    ..In particular, we will investigate the roles of reactive oxygen species, reactive nitrogen species, aberrant VMAT-2 function and newly synthesized DAT to complex formation. C...
  44. Regulation of the Tumor Microenvironment by KSHV
    Christopher H Parsons; Fiscal Year: 2013
    ..subunit, xCT, maintains intracellular glutathione stores to enhance the survival of cells producing reactive nitrogen species (RNS), and xCT was recently identified as a fusion-entry receptor for KSHV (Kaleeba and Berger, Science, ..
  45. Multi-Mechanism Inhibition of Lipid Peroxidation in TBI
    Edward D Hall; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): We have previously documented that generation of the potent reactive nitrogen species (RNS) peroxynitrite (PN) is responsible for oxidative damage by lipid peroxidation (LP) and protein modification (..
  46. Inhibition of Lipid Peroxidation in SCI
    Edward D Hall; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): We have previously shown that generation of the potent reactive nitrogen species (RNS) peroxynitrite (PN) is responsible for oxidative damage by lipid peroxidation (LP) and protein modification (..
  47. 2012 Oxygen Radicals Gordon Research Conference
    Neil Hogg; Fiscal Year: 2012
    ..Mass spectrometry: A new view of the redox universe, Mitochondria: A redox organelle, Heme proteins and reactive nitrogen species, Redox processes in Cancer biology...
  48. Analysis of interacellular host defenses in Salmonella pathogenesis
    Andres Vazquez-Torres; Fiscal Year: 2013
    ..that mediates global Salmonella pathogenicity island 2 (SPI2) transcription is an important target of reactive nitrogen species (RNS)...
  49. Biocatalytic Use of Cytochrome P450 Enzymes
    SHEEL DODANI; Fiscal Year: 2013
    ..The specific aims for this proposal are to: (1) Develop and evolve existing BM3 variants to utilize reactive nitrogen species to nitrate phenol, (2) Optimize the regioselectivity, product distribution, and substrate scope of BM3 ..
  50. LUNG SURFACE ANTIOXIDANT DEFENSES AGAINST AIR POLLUTANTS
    CARROLL CROSS; Fiscal Year: 2000
    ..with ozone may serve as a protective mechanism against ozone injury, but may result in formation of reactive nitrogen species (NO2 or ONOO-) that can contribute to ozone toxicity...
  51. Influence of Dietary Flavonoids on the Expression of At*
    Carl Keen; Fiscal Year: 2002
    ..by applicant) Oxidative stress is characterized by excessive concentrations of reactive oxygen and reactive nitrogen species (ROS and RNS)...
  52. Reactive nitrogen species in hypoxic fetal brain injury
    Sidhartha Tan; Fiscal Year: 2007
    ..baby brain injury from oxygen deficiency, such as production of a certain type of free radicals, called reactive nitrogen species. These are highly reactive chemicals originating from nitric oxide and superoxide...
  53. Campylobacter jejuni and Reactive Nitrogen Species
    Nicole Iovine; Fiscal Year: 2007
    ..an independent research career with an emphasis on understanding the relationship between host-derived reactive nitrogen species and the disease-causing potential of Campylobacter jejuni...
  54. MEMBERS OF THE YJGF SUPERFAMILY NEUTRALIZE ENDOGENOUS METABOLIC STRESSORS
    Diana M Downs; Fiscal Year: 2013
    ..on a bacterial protein (YjgF) that is a member of highly conserved protein family that neutralizes reactive nitrogen species (e.g. enamines)...
  55. Oxidative Stress and Nitric Oxide in Aged Myocardium
    ROBERT LASLEY; Fiscal Year: 2005
    ..that aging associated oxidative stress and mitochondrial dysfunction is due to increased formation of reactive nitrogen species. In Aim 1 studies adult (6 month) and aged (24 month) Fischer 344 x Brown Norway F1 hybrid (F344xBN) ..
  56. Xanthine DNA Glycosylase in Mammalian Systems
    Weiguo Cao; Fiscal Year: 2010
    ..of oxidative stress caused by exposure to nitric oxide and its derivatives, collectively known as reactive nitrogen species (RNS)...
  57. Biological Chemistry of Reactive Nitrogen Species Signaling in Cancer Etiology
    Jack R Lancaster; Fiscal Year: 2013
    ..Our experimental systems will span "test-tube" studies with small molecules to cells and proteins and finally to studies using a tumor model in mice. Insights we obtain may form the basis for the development of new therapies for cancer. ..
  58. OXIDANT MECHANISMS IN DRUG-INDUCED HEPATIC NECROSIS
    Charles Smith; Fiscal Year: 2006
    ..Recent preliminary data indicate that reactive nitrogen species may contribute significantly to the mechanisms of injury in the primary models we study, and the ..
  59. Atherogenic Effects of Tyrosine Oxidation in HDL
    John Oram; Fiscal Year: 2004
    ..stable products of protein oxidation generated by phagocyte-derived hypochlorous acid (HOCI) and reactive nitrogen species (RNS), have been detected in human atherosclerotic lesions...
  60. REGULATION OF RYANODINE RECEPTOR BY NITROGEN OXIDES
    Jerry Eu; Fiscal Year: 2003
    ..regulation of an intracellular calcium release channel (the ryanodine receptor) in skeletal muscle by reactive nitrogen species (RNS). All three isoforms of nitric oxide synthase (NOS) have been identified in skeletal muscle...
  61. MODULATION OF EGF-RECEPTOR SIGNALING
    Albert van Der Vliet; Fiscal Year: 2001
    ..Interactions between NO and inflammatory oxidants results in formation of more reactive nitrogen species, such as nitrogen dioxide (NO2), peroxynitrite (ONOO-) or nitryl halides, which are proposed to ..
  62. NITRIC OXIDE SIGNALING IN ALLERGIC AIRWAY DISEASE
    Albert van Der Vliet; Fiscal Year: 2007
    ..metabolism of NO" is likely to be altered because of oxidative conversion to potentially proinflammatory reactive nitrogen species (RNS), and bioactivity of NO" (through S-nitrosation) may be reduced...
  63. NO DAMAGE TO FOLATE CYCLE IN THE CENTRAL NERVOUS SYSTEM
    Kenneth Hensley; Fiscal Year: 2005
    ..We hypothesize that reactive nitrogen species (RNS) generated endogenously within the aging CNS damage key enzymes of the folate pathway, particularly ..
  64. Endothelial NAD[P]H oxidase in hyperoxic lung injury
    Viswanathan Natarajan; Fiscal Year: 2005
    ..lung injury are not well defined, however, elevated levels of reactive oxygen species (ROS) and reactive nitrogen species with decreased alveolar glutathione may account for the pulmonary toxicity, endothelial damage, and ..