cyanides

Summary

Summary: Inorganic salts of HYDROGEN CYANIDE containing the -CN radical. The concept also includes isocyanides. It is distinguished from NITRILES, which denotes organic compounds containing the -CN radical.

Top Publications

  1. ncbi A radical solution for the biosynthesis of the H-cluster of hydrogenase
    John W Peters
    Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA
    FEBS Lett 580:363-7. 2006
  2. ncbi Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning?
    Alan H Hall
    Toxicology Consulting and Medical Translating Services, Inc, Elk Mountain, WY 82324, USA
    Ann Emerg Med 49:806-13. 2007
  3. ncbi Purification and characterization of chlorite dismutase: a novel oxygen-generating enzyme
    C G van Ginkel
    Akzo Nobel Central Research, Analytical and Environmental Chemistry Department, Velperweg 76, 6800 SB Arnhem, The Netherlands
    Arch Microbiol 166:321-6. 1996
  4. pmc The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors
    Mark Watson
    Gemin X Pharmaceuticals Canada Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, Canada
    Mol Cell Biol 29:5872-88. 2009
  5. ncbi Methods for assaying cyanide in bacterial culture supernatant
    J E A Zlosnik
    Department of Biological Sciences, Imperial College London, London, UK
    Lett Appl Microbiol 38:360-5. 2004
  6. ncbi Identification of Chromobacterium violaceum genes with potential biotechnological application in environmental detoxification
    Marta S P Carepo
    Departamento de Genética Laboratório de Polimorfismo de DNA, Universidade Federal do Para, Campus Universitario do Guama, Rua Augusto Correa, 01, 66075 970 Belém, PA, Brasil
    Genet Mol Res 3:181-94. 2004
  7. pmc Involvement of Pseudomonas aeruginosa rhodanese in protection from cyanide toxicity
    Rita Cipollone
    Dipartimento di Biologia, Universita Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    Appl Environ Microbiol 73:390-8. 2007
  8. ncbi Neurological disorders associated with cassava diet: a review of putative etiological mechanisms
    Bola Adamolekun
    Department of Neurology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Metab Brain Dis 26:79-85. 2011
  9. pmc Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner
    William L Cody
    University of Colorado Denver, School of Medicine, Department of Microbiology, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Bacteriol 191:2993-3002. 2009
  10. ncbi Taming of a poison: biosynthesis of the NiFe-hydrogenase cyanide ligands
    Stefanie Reissmann
    Department Biologie I, Mikrobiologie, University of Munich, Maria Ward Strasse 1a, D 80638 Munich, Germany
    Science 299:1067-70. 2003

Research Grants

Detail Information

Publications208 found, 100 shown here

  1. ncbi A radical solution for the biosynthesis of the H-cluster of hydrogenase
    John W Peters
    Department of Chemistry and Biochemistry, Montana State University, Bozeman, MT 59717, USA
    FEBS Lett 580:363-7. 2006
    ..The ideas presented have broader implications in the context of the prebiotic origin of amino acids...
  2. ncbi Sodium thiosulfate or hydroxocobalamin for the empiric treatment of cyanide poisoning?
    Alan H Hall
    Toxicology Consulting and Medical Translating Services, Inc, Elk Mountain, WY 82324, USA
    Ann Emerg Med 49:806-13. 2007
    ..Hydroxocobalamin is being developed for potential introduction in the United States and may represent a new option for emergency personnel in cases of suspected or confirmed cyanide poisoning in the out-of-hospital setting...
  3. ncbi Purification and characterization of chlorite dismutase: a novel oxygen-generating enzyme
    C G van Ginkel
    Akzo Nobel Central Research, Analytical and Environmental Chemistry Department, Velperweg 76, 6800 SB Arnhem, The Netherlands
    Arch Microbiol 166:321-6. 1996
    ..The enzyme was red-colored and had a Soret peak at 392 nm. Per subunit, it contained 0.9 molecule of protoheme IX and 0.7 molecule of iron. Chlorite dismutase displayed maxima for activity at pH 6.0 and 30 degrees C...
  4. pmc The small molecule GMX1778 is a potent inhibitor of NAD+ biosynthesis: strategy for enhanced therapy in nicotinic acid phosphoribosyltransferase 1-deficient tumors
    Mark Watson
    Gemin X Pharmaceuticals Canada Inc, 3576 Avenue du Parc, Suite 4310, Montreal, Quebec, Canada
    Mol Cell Biol 29:5872-88. 2009
    ..This provides the rationale for a novel therapeutic approach for the use of GMX1777 in the treatment of human cancers...
  5. ncbi Methods for assaying cyanide in bacterial culture supernatant
    J E A Zlosnik
    Department of Biological Sciences, Imperial College London, London, UK
    Lett Appl Microbiol 38:360-5. 2004
    ..To find an easy, rapid and direct method for the quantitation of cyanide in a moderate number of bacterial culture supernatants...
  6. ncbi Identification of Chromobacterium violaceum genes with potential biotechnological application in environmental detoxification
    Marta S P Carepo
    Departamento de Genética Laboratório de Polimorfismo de DNA, Universidade Federal do Para, Campus Universitario do Guama, Rua Augusto Correa, 01, 66075 970 Belém, PA, Brasil
    Genet Mol Res 3:181-94. 2004
    ..Probable catalytic mechanisms for the enzymes were determined, based on amino acid sequence comparisons and on published structural information for these types of proteins...
  7. pmc Involvement of Pseudomonas aeruginosa rhodanese in protection from cyanide toxicity
    Rita Cipollone
    Dipartimento di Biologia, Universita Roma Tre, Viale G Marconi 446, 00146 Rome, Italy
    Appl Environ Microbiol 73:390-8. 2007
    ..aeruginosa intrinsic resistance to cyanide, insofar as it provides the bacterium with a defense mechanism against endogenous cyanide toxicity, in addition to cyanide-resistant respiration...
  8. ncbi Neurological disorders associated with cassava diet: a review of putative etiological mechanisms
    Bola Adamolekun
    Department of Neurology, University of Tennessee Health Science Center, 855 Monroe Avenue, Memphis, TN 38163, USA
    Metab Brain Dis 26:79-85. 2011
    ..It is concluded that urgent research is needed to evaluate thiamine status and implement a therapeutic trial of thiamine in these debilitating neurological disorders...
  9. pmc Pseudomonas aeruginosa AlgR controls cyanide production in an AlgZ-dependent manner
    William L Cody
    University of Colorado Denver, School of Medicine, Department of Microbiology, 12800 E 19th Avenue, Aurora, CO 80045, USA
    J Bacteriol 191:2993-3002. 2009
    ..aeruginosa hcnA promoter contains three transcriptional start sites and that HCN production is regulated by AlgZ and AlgR and is maximal under microaerobic conditions when the organism is surface attached...
  10. ncbi Taming of a poison: biosynthesis of the NiFe-hydrogenase cyanide ligands
    Stefanie Reissmann
    Department Biologie I, Mikrobiologie, University of Munich, Maria Ward Strasse 1a, D 80638 Munich, Germany
    Science 299:1067-70. 2003
    ..This finding underscores a striking parallel between biochemistry and organometallic chemistry in the formation of an iron-cyano complex...
  11. ncbi Redox thermodynamics of the Fe(3+)/Fe(2+) couple in horseradish peroxidase and its cyanide complex
    Gianantonio Battistuzzi
    Department of Chemistry, University of Modena and Reggio Emilia, Via Campi 183, 41100 Modena, Italy
    J Am Chem Soc 124:26-7. 2002
    ..The decrease in E degrees ' of the Fe3+/Fe2+ couple on cyanide binding turns out to be a fully entropic effect, unequivocally demonstrating the importance of entropic effects in determining the E degrees ' values of redox metal centers...
  12. ncbi Effects of cyanide and dissolved oxygen concentration on biological Au recovery
    Yoshito Kita
    Graduate School of Engineering, Osaka University, Japan
    J Biotechnol 124:545-51. 2006
    ..25 mmol/l. Therefore, it was clarified that dissolved oxygen concentration is the main factor affecting the efficiency of cyanide leaching of gold by using bacteria...
  13. ncbi Biogenic production of cyanide and its application to gold recovery
    S C Campbell
    The Center for Biofilm Engineering and Microbiology Department, Montana State University, Bozeman 59717, USA
    J Ind Microbiol Biotechnol 26:134-9. 2001
    ..This indicates that biogenesis of cyanide may be supported in remote areas using locally produced and inexpensive agricultural feedstocks in place of commercial media...
  14. ncbi Exposure to cyanide following a meal of cassava food
    O S A Oluwole
    Department of Medicine, Neurology Unit, College of Medicine, University of Ibadan, Ibadan, Nigeria
    Toxicol Lett 135:19-23. 2002
    ..The long transit time of absorbed cyanide in the plasma suggests that frequent intake of gari could cause cyanide to accumulate in the plasma...
  15. ncbi Low prevalence of ataxic polyneuropathy in a community with high exposure to cyanide from cassava foods
    O S A Oluwole
    Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Nigeria
    J Neurol 249:1034-40. 2002
    ..Both communities have been shown to have high exposure to cyanide from cassava foods...
  16. ncbi Toxicology in the ICU: Part 2: specific toxins
    Daniel E Brooks
    Department of Medical Toxicology, Banner Good Samaritan Medical Center, Phoenix, AZ 85006, USA
    Chest 140:1072-85. 2011
    ..The first article discussed the general approach to the toxicology patient, including laboratory testing; the third article will cover natural toxins...
  17. ncbi Solution 1H NMR study of the active site structure for the double mutant H64Q/V68F cyanide complex from mouse neuroglobin
    Guowei Yin
    Department of Chemistry, Renmin University of China, Beijing 100872, China
    Biophys Chem 136:115-23. 2008
    ....
  18. ncbi Simultaneous effect of temperature, cyanide and ammonia-oxidizing bacteria concentrations on ammonia oxidation
    Hyojin Do
    School of Environmental Science and Engineering, Pohang University of Science and Technology POSTECH, San 31, Hyoja Dong, Nam Gu, Pohang, Gyungbuk, 790 784, South Korea
    J Ind Microbiol Biotechnol 35:1331-8. 2008
    ..The statistical method used in this study can be extended to estimate the quantitative effects of other environmental factors that can change simultaneously...
  19. ncbi Automatic biodetector of water toxicity (ABTOW) as a tool for examination of phenol and cyanide contaminated water
    Andrzej Woznica
    Department of Biochemistry, Faculty of Biology and Environmental Protection, University of Silesia, 40 032 Katowice, Poland
    Chemosphere 81:767-72. 2010
    ..One may conclude that the presented biodetector provides a good sensitivity for continuous on-line monitoring of toxicity in water...
  20. ncbi Crystal structures of unligated and CN-ligated Glycera dibranchiata monomer ferric hemoglobin components III and IV
    Ha Jeung Park
    School of Molecular Biosciences, Washington State University, Pullman, Washington 99164 4660, USA
    Proteins 49:49-60. 2002
    ....
  21. pmc Recent developments in cyanide detection: a review
    Jian Ma
    Department of Chemistry and Biochemistry, University of Texas, 700 Planetarium Place, Arlington, TX 76019 0065, United States
    Anal Chim Acta 673:117-25. 2010
    ....
  22. ncbi Cyanide fishing and cyanide detection in coral reef fish using chemical tests and biosensors
    Karen K W Mak
    Department of Chemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
    Biosens Bioelectron 20:2581-93. 2005
    ..A novel approach to detect cyanide in marine fish tissues is briefly discussed...
  23. pmc Incidence of endemic ataxic polyneuropathy and its relation to exposure to cyanide in a Nigerian community
    O S A Oluwole
    Neurology Unit, Department of Medicine, College of Medicine, University of Ibadan, Ibadan, Nigeria
    J Neurol Neurosurg Psychiatry 74:1417-22. 2003
    ..However, it has been shown that the prevalence of ataxic polyneuropathy is not high in several communities in the tropics where exposure to cyanide from cassava foods is high...
  24. pmc Evolution of heteromeric nitrilase complexes in Poaceae with new functions in nitrile metabolism
    Roland Jenrich
    Department of Plant Physiology, Ruhr Universitat Bochum, 44801 Bochum, Germany
    Proc Natl Acad Sci U S A 104:18848-53. 2007
    ..Through combinatorial biochemistry and neofunctionalizations, the small family of nitrilases has gained diverse biological functions in nitrile metabolism...
  25. ncbi A glycyl free radical as the precursor in the synthesis of carbon monoxide and cyanide by the [FeFe]-hydrogenase maturase HydG
    Yvain Nicolet
    Laboratoire de Cristallographie et de Cristallogenese des Proteines, Institut de Biologie Structurale Jean Pierre Ebel, CEA, CNRS, Universite Joseph Fourier, Grenoble, France
    FEBS Lett 584:4197-202. 2010
    ..We postulate that CN(-)/CO synthesis is initiated by H(2)N-*CH-CO(2)(-). Fragmentation of this radical into H(2)N-*CH(2) and CO(2) or H(2)C=NH and *CO(2)(-) provides plausible precursors for CN(-)/CO synthesis...
  26. ncbi Leaching of cyanogenic glucosides and cyanide from white clover green manure
    Nanna Bjarnholt
    Plant Biochemistry Laboratory, Department of Plant Biology and Biotechnology, University of Copenhagen, 40 Thorvaldsensvej, DK 1871 Frederiksberg C, Copenhagen, Denmark
    Chemosphere 72:897-904. 2008
    ....
  27. ncbi A highly sensitive and selective chemosensor for cyanide
    Jiaqiang Ren
    Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, PR China
    Talanta 75:760-4. 2008
    ..The cyanide detection method should have potential application in a variety of settings requiring rapid and accurate analysis of cyanide anion for drinking and fresh water...
  28. ncbi Sensors for the optical detection of cyanide ion
    Zhaochao Xu
    Department of Chemistry and Nano Science, Ewha Womans University, Seoul 120 750, Korea
    Chem Soc Rev 39:127-37. 2010
    ....
  29. ncbi Enhancement of cyanide-induced mitochondrial dysfunction and cortical cell necrosis by uncoupling protein-2
    L Li
    Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, Indiana 47907 1333, USA
    Toxicol Sci 86:116-24. 2005
    ..It is concluded that UCP-2 levels influence cellular responses to cyanide-induced mitochondrial dysfunction...
  30. ncbi Stability of cyanogen chloride in the presence of free chlorine and monochloramine
    Chongzheng Na
    Environmental and Water Resource Engineering, Department of Civil and Environmental Engineering, University of Michigan, Ann Arbor, Michigan 48109 2125, USA
    Environ Sci Technol 38:6037-43. 2004
    ..The results of this study demonstrate that the observed association of CNCl with chloramination systems can in part be explained by the differences in its stability with chlorine and chloramines...
  31. ncbi The soluble [NiFe]-hydrogenase from Ralstonia eutropha contains four cyanides in its active site, one of which is responsible for the insensitivity towards oxygen
    Eddy van der Linden
    Swammerdam Institute for Life Sciences, Biochemistry, University of Amsterdam, Plantage Muidergracht 12, 1018 TV Amsterdam, The Netherlands
    J Biol Inorg Chem 9:616-26. 2004
    ..The Ni-Fe active site was EPR undetectable under all conditions tested. It is concluded that the Ni-bound cyanide group is responsible for the oxygen insensitivity of the enzyme...
  32. pmc CynD, the cyanide dihydratase from Bacillus pumilus: gene cloning and structural studies
    Dakshina Jandhyala
    Department of Biology and Biochemistry University of Houston, Houston, Texas 77204, USA
    Appl Environ Microbiol 69:4794-805. 2003
    ..pumilus (strain 8A3) was cloned and expressed. This suggests that cynD, the gene coding for the cyanide dihydratase, is not unique to the C1 strain of B. pumilus and is not a reflection of its origin at a mining waste site...
  33. ncbi Volatile disinfection by-product analysis from chlorinated indoor swimming pools
    William A Weaver
    School of Civil Engineering, Purdue University, 550 Stadium Mall Drive, West Lafayette, IN 47907 2051, USA
    Water Res 43:3308-18. 2009
    ..Pairwise correlations among the measured volatile DBPs allowed identification of dichloromethylamine and dichloroacetonitrile as potential swimming pool water quality indicator compounds...
  34. ncbi Hyperthermal stability of neuroglobin and cytoglobin
    Djemel Hamdane
    INSERM U473, Le Kremlin Bicetre, France
    FEBS J 272:2076-84. 2005
    ....
  35. ncbi Fluorescent chemodosimeter for selective detection of cyanide in water
    Kyung Sik Lee
    Department of Chemistry, College of Natural Sciences, Seoul National University, Seoul 151 747, Korea
    Org Lett 10:49-51. 2008
    ..A coumarin-based fluorescent chemodosimeter with a salicylaldehyde functionality as a binding site has been developed for selective detection of cyanide anions over other anions in water at biological pH...
  36. ncbi Focus on smoke inhalation--the most common cause of acute cyanide poisoning
    Marc Eckstein
    Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Prehosp Disaster Med 21:s49-55. 2006
    ....
  37. ncbi Resonance Raman spectroscopic study of nitrophorin 1, a nitric oxide-binding heme protein from Rhodnius prolixus, and its nitrosyl and cyano adducts
    E M Maes
    Department of Chemistry, University of Houston, Houston, Texas 77204, USA
    J Am Chem Soc 123:11664-72. 2001
    ..We also find that the observed frequencies are consistent with the presence of a nearly linear Fe(III)CN(-) linkage (173 degrees ) coexisting with a population with a bent structure (155 degrees )...
  38. ncbi Development and characterization of two human tumor sublines expressing high-grade resistance to the cyanoguanidine CHS 828
    Joachim Gullbo
    Department of Medical Sciences, Division of Clinical Pharmacology, University Hospital, Uppsala, Sweden
    Anticancer Drugs 15:45-54. 2004
    ..The findings presented here indicate that development of specific cellular alterations is responsible for the gained CHS 828 resistance...
  39. ncbi Cytotoxic effect in vivo and in vitro of CHS 828 on human myeloma cell lines
    Peter Hovstadius
    Department of Medical Sciences, Division of Clinical Pharmacology, Uppsala University, Uppsala, Sweden
    Anticancer Drugs 15:63-70. 2004
    ..The results indicate a high cytotoxic activity of CHS 828. Overall, the results show a high cytotoxic activity of CHS 828 in the myeloma models, which might warrant its further development against myeloma...
  40. ncbi Expression of MdCAS1 and MdCAS2, encoding apple beta-cyanoalanine synthase homologs, is concomitantly induced during ripening and implicates MdCASs in the possible role of the cyanide detoxification in Fuji apple (Malus domestica Borkh.) fruits
    Sang Eun Han
    Department of Biology, College of Science, Yonsei University, Seoul 120 749, South Korea
    Plant Cell Rep 26:1321-31. 2007
    ..Overall, these results suggest that MdCAS may play a role in cyanide detoxification in ripening apple fruits...
  41. ncbi Pediatric cyanide poisoning: causes, manifestations, management, and unmet needs
    Robert J Geller
    Department of Pediatrics and the Medical Toxicology Fellowship Program, Emory University School of Medicine, Atlanta, Georgia, USA
    Pediatrics 118:2146-58. 2006
    ..In this article we review the available data on the sources, manifestations, and treatment of acute cyanide poisoning in children and discuss unmet needs in the management of pediatric cyanide poisoning...
  42. ncbi Antitumoural effects of the pyridyl cyanoguanidine CHS 828 on three different types of neuroendocrine tumours xenografted to nude mice
    Viktor Johanson
    The Lundberg Laboratory for Cancer Research, Sahlgrenska University Hospital, Goteborg, Sweden
    Neuroendocrinology 82:171-6. 2005
    ..Our results indicate that CHS 828 can be a candidate drug for treatment of neuroendocrine tumours...
  43. ncbi Anticancer agent CHS 828 suppresses nuclear factor-kappa B activity in cancer cells through downregulation of IKK activity
    Lone Stengelshøj Olsen
    LEO Pharma, Ballerup, Denmark
    Int J Cancer 111:198-205. 2004
    ..Therefore, we hypothesize that the anticancer activity of CHS 828 is due to inhibition of the IKK activity by which the antiapoptotic protection of NF-kappa B is removed, leading to the promotion of apoptosis...
  44. ncbi Assignment of the ferriheme resonances of high- and low-spin forms of the symmetrical hemin-reconstituted nitrophorins 1-4 by 1H and 13C NMR spectroscopy: the dynamics of heme ruffling deformations
    Tatiana K Shokhireva
    Department of Chemistry, The University of Arizona, Tucson, AZ 85721 0041, USA
    J Biol Inorg Chem 13:941-59. 2008
    ..Two other types of dynamics, i.e., changes in heme seating and NMeIm rotation, are also observed. The highly distorted heme and the dynamics it causes are unique to the NPs and a few other heme proteins with highly distorted macrocycles...
  45. ncbi Anticancer agent CHS-828 inhibits cellular synthesis of NAD
    Uffe Høgh Olesen
    Experimental Pathology Unit, National University Hospital, Biocentre, Building 2, 3rd Floor, Ole Maaloes Vej 5, 2200 Copenhagen, Denmark
    Biochem Biophys Res Commun 367:799-804. 2008
    ..Finally, we observed that treatment with CHS-828 depletes cellular NAD levels in sensitive cancer cells. In conclusion, these results strongly suggest that, like FK866, CHS-828 kills cancer cells by depleting NAD...
  46. pmc Geometries and electronic structures of cyanide adducts of the non-heme iron active site of superoxide reductases: vibrational and ENDOR studies
    Michael D Clay
    Department of Chemistry, University of Georgia, Athens, Georgia 30602, USA
    Biochemistry 45:427-38. 2006
    ..The implications of these results for understanding the mechanism of SOR are discussed...
  47. pmc Assignment of the ferriheme resonances of the low-spin complexes of nitrophorins 1 and 4 by (1)H and (13)C NMR spectroscopy: comparison to structural data obtained from X-ray crystallography
    Tatiana Kh Shokhireva
    Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, USA
    Inorg Chem 46:2041-56. 2007
    ..The A:B ratio can be much more accurately measured by NMR spectroscopy than by X-ray crystallography...
  48. ncbi Temporal effects of the novel antitumour pyridyl cyanoguanidine (CHS 828) on human lymphoma cells
    P Martinsson
    Division of Clinical Pharmacology, University Hospital, Uppsala University, S 751 85, Uppsala, Sweden
    Eur J Cancer 37:260-7. 2001
    ..The results indicate that CHS 828 induced active and delayed cell death with a non-apoptotic morphology...
  49. ncbi Potential for error when assessing blood cyanide concentrations in fire victims
    F Moriya
    Department of Legal Medicine, Kochi Medical School, Nankoku City, Japan
    J Forensic Sci 46:1421-5. 2001
    ..The present results and those published in the literature demonstrate that the toxic effects of cyanide on fire victims should not be evaluated based solely on the concentration in blood...
  50. ncbi X-ray crystallographic study of cyanide binding provides insights into the structure-function relationship for cytochrome cd1 nitrite reductase from Paracoccus pantotrophus
    A Jafferji
    Laboratory of Molecular Biophysics, Department of Biochemistry, University of Oxford, United Kingdom
    J Biol Chem 275:25089-94. 2000
    ....
  51. ncbi CHS 828 inhibits neuroblastoma growth in mice alone and in combination with antiangiogenic drugs
    Asa Svensson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Pediatr Res 51:607-11. 2002
    ..Furthermore, they imply efficiency of daily administration of nontoxic doses of chemotherapy, and a possible additive effect when chemotherapy is combined with angiogenesis inhibitors...
  52. ncbi Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution
    M Blair-Johnson
    Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, Miami, Florida 33101, USA
    Biochemistry 40:13990-7. 2001
    ..These results support a model for a single common binding site for halides and thiocyanate as substrates or as inhibitors near the delta-meso carbon of the porphyrin ring in myeloperoxidase...
  53. ncbi Activity of CHS 828 in primary cultures of human hematological and solid tumors in vitro
    A Aleskog
    Department of Internal Medicine, University Hospital, 751 85 Uppsala, Sweden
    Anticancer Drugs 12:821-7. 2001
    ..The results show that CHS 828 has potent antitumor activity against primary cultures of human tumor cells from patients and might have a unique mechanism of action...
  54. ncbi In vitro activity of the novel cytotoxic agent CHS 828 in childhood acute leukemia
    B M Frost
    Department of Women s and Children s Health, University Hospital, Uppsala, Sweden
    Anticancer Drugs 13:735-42. 2002
    ..In most ALL samples subadditive effects were found. Further exploration of CHS 828 in childhood leukemia is warranted, especially in AML...
  55. ncbi Hydrogen-bonding interactions in the active sites of cytochrome P450cam and its site-directed mutants
    T Deng
    Department of Chemistry, Marquette University, Wehr Chemistry Building, P.O. Box1881 (535 North 14th Street, 53233, Milwaukee, Wisconsin 53201-1881, USA
    J Am Chem Soc 123:269-78. 2001
    ....
  56. ncbi CHS 828, a novel pyridyl cyanoguanidine with potent antitumor activity in vitro and in vivo
    P J Hjarnaa
    Leo Pharmaceutical Products, Ballerup, Denmark
    Cancer Res 59:5751-7. 1999
    ..CHS 828 is presently being tested in Phase I clinical trials in collaboration with the European Organization for Research and Treatment of Cancer...
  57. pmc Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study
    M Bolognesi
    Dipartimento di Fisica INFM, Universita di Genova, and Centro Biotecnologie Avanzate IST, I 16132 Genova, Italy
    Biophys J 77:1093-9. 1999
    ..The unusual cyanide distal site orientation observed in L. pectinata HbI, at room temperature, may reflect reduction of the heme Fe(III) atom induced by free radical species during x-ray data collection using Cu Kalpha radiation...
  58. ncbi Model for time dependency of cytotoxic effect of CHS 828 in vitro suggests two different mechanisms of action
    S B Hassan
    Division of Clinical Pharmacology, University Hospital, Uppsala University, Uppsala, Sweden
    J Pharmacol Exp Ther 299:1140-7. 2001
    ..This could indicate two distinct mechanisms of induction of cell death...
  59. ncbi Cell death with atypical features induced by the novel antitumoral drug CHS 828, in human U-937 GTB cells
    P Martinsson
    Department of Medical Sciences, Clinical Pharmacology, University Hospital, Uppsala University, SE 751 85 Uppsala, Sweden
    Eur J Pharmacol 417:181-7. 2001
    ..Thus, CHS 828 induces several unexpected features in this system, suggesting a potentially novel mechanism of action...
  60. pmc Linamarase expression in cassava cultivars with roots of low- and high-cyanide content
    Maria Angélica Santana
    Departmento de Biologia Celular, División de Ciencias Biológicas, Universidad Simon Bolivar, Caracas, Venezuela
    Plant Physiol 129:1686-94. 2002
    ..Reverse transcriptase-PCR on cassava tissues showed no expression of linamarase in cassava roots, thus, the transport of linamarase from shoots to roots through laticifers is proposed...
  61. ncbi Metal solubilization from metal-containing solid materials by cyanogenic Chromobacterium violaceum
    Mohammad A Faramarzi
    Institute of Environmental Sciences, University of Zurich, Winterthurerstrasse 190, CH 8057, Switzerland
    J Biotechnol 113:321-6. 2004
    ..All microorganisms were able to form water-soluble metal cyanides, however, with different efficiencies. C...
  62. ncbi Phase I study and pharmacokinetic of CHS-828, a guanidino-containing compound, administered orally as a single dose every 3 weeks in solid tumours: an ECSG/EORTC study
    Alain Ravaud
    Department of Medicine, Institut Bergonie, Bordeaux, France
    Eur J Cancer 41:702-7. 2005
    ..The pharmacokinetics of CHS 828 showed large variations both between and within patients. No objective responses were seen. A dose of 420 mg of CHS 828 administered every 3 weeks is the recommended dose, while 500 mg is the MTD...
  63. ncbi Cyanides
    Anthony P Morocco
    Guam Memorial Hospital, Department of Emergency Medicine, 850 Gov Carlos Camacho Road, Oka, Tamuning, Guam
    Crit Care Clin 21:691-705, vi. 2005
    ..Survivors of significant poisonings can have long-term neurologic dysfunction...
  64. ncbi Accumulation of cyanide and thiocyanate in haemodialysis patients
    Yukiko Hasuike
    Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine, Japan
    Nephrol Dial Transplant 19:1474-9. 2004
    ..However, inaccuracies in conventional assays for cyanide and thiocyanate have limited the understanding of their metabolism in haemodialysis (HD) patients...
  65. ncbi Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study
    Wolfgang Uhl
    Merck KGaA, Darmstadt, Germany
    Clin Toxicol (Phila) 44:17-28. 2006
    ..This randomized, double-blind, placebo-controlled, ascending-dose study was conducted in healthy volunteers to evaluate the safety of the investigational cyanide antidote hydroxocobalamin...
  66. ncbi Hydroxocobalamin as a cyanide antidote
    Carol Ann DesLauriers
    Illinois Poison Center, Chicago, Illinois 60606, USA
    Am J Ther 13:161-5. 2006
  67. ncbi Which cyanide antidote?
    Alan H Hall
    Toxicology Consulting and Medical Translating Services, Inc, Laramie, WY 82072, USA
    Crit Rev Toxicol 39:541-52. 2009
    ....
  68. ncbi Pharmacokinetic-pharmacodynamic modelling of the schedule-dependent effect of the anti-cancer agent CHS 828 in a rat hollow fibre model
    Lena E Friberg
    Division of Pharmacokinetics and Drug Therapy, Uppsala University, Uppsala, Sweden
    Eur J Pharm Sci 25:163-73. 2005
    ..The prolonged schedules of CHS 828 were therefore associated with greater antitumour effects than single doses of the same total exposure...
  69. ncbi A Phase I study of CHS 828 in patients with solid tumor malignancy
    Peter Hovstadius
    Department of Clinical Pharmacology, Uppsala University, S 751 85 Uppsala, Sweden
    Clin Cancer Res 8:2843-50. 2002
    ..There was an apparent inverse relationship between systemic exposure of CHS 828, and thrombocyte and lymphocyte nadir levels. No objective tumor responses were observed, and 7 patients showed stable disease after two courses of therapy...
  70. ncbi Contribution of heme-propionate side chains to structure and function of myoglobin: chemical approach by artificially created prosthetic groups
    Takashi Hayashi
    Department of Chemistry and Biochemistry, Graduate School of Engineering, Kyushu University, Fukuoka 812 8581, Japan
    J Inorg Biochem 91:94-100. 2002
    ..Thus, it is found that the 7-propionate regulates the hydrogen-bonding network and His93-heme iron coordination in the proximal site...
  71. pmc Sulfur K-edge X-ray absorption spectroscopy and density functional theory calculations on superoxide reductase: role of the axial thiolate in reactivity
    Abhishek Dey
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 129:12418-31. 2007
    ..However, in contrast to FeSOD, the 5C FeIII site of SOR, which is more positively charged, is calculated to have a high affinity for binding a sixth anionic ligand, which would inhibit its SOD activity...
  72. ncbi Chemical shift-based constraints for solution structure determination of paramagnetic low-spin heme proteins with bis-His and His-CN axial ligands: the cases of oxidized cytochrome b(5) and Met80Ala cyano-cytochrome c
    Lucia Banci
    Magnetic Resonance Center CERM and Department of Chemistry, University of Florence, Via Luigi Sacconi 6, 50019 Sesto Fiorentino, Florence, Italy
    J Biol Inorg Chem 7:416-26. 2002
    ..In the case of scarcity of NOEs for the axial ligands, owing to the presence of the paramagnetic center, the above structural constraints are shown to be quite precious. The newly refined structures are deposited in the PDB...
  73. ncbi Unusual cytochrome a592 with low PO2 affinity correlates as putative oxygen sensor with rat carotid body chemoreceptor discharge
    Tino Streller
    Institut für Physiologie der Universität Rostock, 18057 Rostock, Germany
    FASEB J 16:1277-9. 2002
    ....
  74. ncbi Electron-rich diferrous-phosphane-thiolates relevant to Fe-only hydrogenase: is cyanide "nature's trimethylphosphane"?
    Jarl Ivar van der Vlugt
    Department of Chemistry, University of Illinois at Urbana Champaign, 505 S Mathews St, Urbana, IL 61801, USA
    Chemistry 12:90-8. 2005
    ..Relevant to the H(red) state of the active site of Fe-only hydrogenases, the unsymmetrical derivatives 5 and 6 feature a semibridging CO ligand trans to a labile coordination site...
  75. ncbi Electronic structure of mononuclear bis(1,2-diaryl-1,2-ethylenedithiolato)iron complexes containing a fifth cyanide or phosphite ligand: a combined experimental and computational study
    Apurba K Patra
    Max Planck Institut fur Bioanorganische Chemie, Stiftstrasse 34 36, D 45470 Mulheim an der Ruhr, Germany
    Inorg Chem 45:7877-90. 2006
    ..The electronic structures of 1 and 1(ox) have been established by density functional theoretical calculations: [Fe(II)(1L*)2(CN)]1- (SFe = 0, St = 0) and [Fe(III)(1L*)2(CN)]0 (SFe = 3/2, St = 1/2)...
  76. ncbi A comparative study of O2, CO and CN binding to heme IX protein models
    Francisco Torrens
    Institut Universitari de Ciència Molecular, Universitat de Valencia, Dr Moliner 50, E 46100 Burjassot Valencia, Spain
    Molecules 9:632-49. 2004
    ..Axial ligands are practically free-rotating. A small modification of the model in both crystal and protein matrix affects the orientation of the ligands in experimental systems...
  77. ncbi Ring-opening and meso substitution from the reaction of cyanide ion with zinc verdohemes
    J A Johnson
    Department of Chemistry, University of California, Davis, California 95616, USA
    Inorg Chem 40:5585-95. 2001
    ....
  78. ncbi Roles of the heme distal residues of FixL in O2 sensing: a single convergent structure of the heme moiety is relevant to the downregulation of kinase activity
    Atsunari Tanaka
    Yokohama City University International Graduate School of Arts and Sciences, Suehiro, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Biochemistry 45:2515-23. 2006
    ....
  79. ncbi Resolving complexity in the interactions of redox enzymes and their inhibitors: contrasting mechanisms for the inhibition of a cytochrome c nitrite reductase revealed by protein film voltammetry
    James D Gwyer
    Centre for Metalloprotein Spectroscopy and Biology, School of Chemical Sciences and Pharmacy, University of East Anglia, Norwich, UK
    Biochemistry 43:15086-94. 2004
    ..These studies demonstrate the complexity that can be associated with inhibitor binding to redox enzymes and illustrate how PFV readily captures and deconvolves this complexity through its impact on the catalytic properties of the enzyme...
  80. ncbi Probing the catalytic mechanism of sulfite reductase by X-ray crystallography: structures of the Escherichia coli hemoprotein in complex with substrates, inhibitors, intermediates, and products
    B R Crane
    Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA
    Biochemistry 36:12120-37. 1997
    ..From the structures reported here, we propose a series of key structural states of ligated SiRHP in the catalytic reduction of sulfite to sulfide...
  81. ncbi Crystal structures of ferrous and CO-, CN(-)-, and NO-bound forms of rat heme oxygenase-1 (HO-1) in complex with heme: structural implications for discrimination between CO and O2 in HO-1
    Masakazu Sugishima
    Department of Biology, Graduate School of Science, Osaka University, Toyonaka, Osaka 560 0043, Japan
    Biochemistry 42:9898-905. 2003
    ..Zhou, H., and Yoshida, T. (1998) J. Biol. Chem. 273, 945-949] is explained by hydrogen bonding and polar interactions that are favorable for O(2) binding, as well as by characteristic structural changes in the CO-bound form...
  82. ncbi Reversal of cyanide inhibition of cytochrome c oxidase by the auxiliary substrate nitric oxide: an endogenous antidote to cyanide poisoning?
    Linda L Pearce
    University of Pittsburgh, Pittsburgh, Pennyslvania 15260, USA
    J Biol Chem 278:52139-45. 2003
    ....
  83. ncbi Development of QSARs for predicting the joint effects between cyanogenic toxicants and aldehydes
    Zhifen Lin
    Key Laboratory of Tropical Marine Environmental Dynamics, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, People s Republic of China
    Chem Res Toxicol 16:1365-71. 2003
    ..By using the charge of carbon atom (C) in the carbochain of cyanogenic toxicants, another QSAR model is proposed to describe the relationship between the joint effects and the chemical structures of cyanogenic toxicants...
  84. ncbi Redox-dependent open and closed forms of the active site of the bacterial respiratory nitric-oxide reductase revealed by cyanide binding studies
    Karin L C Grönberg
    School of Biological Sciences and School of Chemical Sciences and Pharmacy, Centre for Metalloprotein Spectroscopy and Biology, University of East Anglia, Norwich, NR4 7TJ, United Kingdom
    J Biol Chem 279:17120-5. 2004
    ..Our observations suggest that the micro-oxo-bridged [heme Fe(III)-O-Fe(III)] active site represents a closed or resting state of NOR that can be opened by reduction of the non-heme iron...
  85. ncbi The role of serine 167 in human indoleamine 2,3-dioxygenase: a comparison with tryptophan 2,3-dioxygenase
    Nishma Chauhan
    Department of Biochemistry, Henry Wellcome Building, University of Leicester, University Road, Leicester, England
    Biochemistry 47:4761-9. 2008
    ..The data reveal significant differences between the IDO and TDO enzymes, and the implications of these results are discussed in terms of our current understanding of IDO and TDO catalysis...
  86. ncbi Spectroscopic and kinetic characterization of active site mutants of Desulfovibrio fructosovoransNi-Fe hydrogenase
    Antonio L DeLacey
    Instituto de Catalisis, CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    J Biol Inorg Chem 8:129-34. 2003
    ..However, kinetic analysis of the mutants indicates that none of the replaced residues have an important role in the catalytic mechanism of the hydrogenase...
  87. ncbi Resonance Raman detection of the Fe2+-C-N modes in heme-copper oxidases: a probe of the active site
    Eftychia Pinakoulaki
    Department of Chemistry, University of Crete, 71409 Heraklion, Crete, Greece
    Inorg Chem 43:4907-10. 2004
    ....
  88. ncbi Oxidative verdoheme formation and stabilization by axial isocyanide ligation
    Sankar Prasad Rath
    Department of Chemistry, University of California at Davis, One Shields Avenue, Davis, California 95616, USA
    Inorg Chem 43:7648-55. 2004
    ..No resonances due to paramagnetic products could be detected, the reactions appear to result only in the formation of the diamagnetic verdohemes, and the products are not susceptible to further oxidation...
  89. ncbi Structure-based mechanism of O2 sensing and ligand discrimination by the FixL heme domain of Bradyrhizobium japonicum
    Bing Hao
    Department of Biochemistry, and The Ohio State Biophysics Program, The Ohio State University, 484 West 12th Avenue, Columbus, Ohio 43210, USA
    Biochemistry 41:12952-8. 2002
    ..In the revised structure, Arg 220 was found to move into the heme pocket to form a hydrogen bond to the bound cyanide ligand. The implications of these results on FixL's sensing mechanism are discussed...
  90. ncbi Distal Cu ion protects synthetic heme/Cu analogues of cytochrome oxidase against inhibition by CO and cyanide
    James P Collman
    Department of Chemistry, Stanford University, Stanford, CA 94305, USA
    Angew Chem Int Ed Engl 41:4139-42. 2002
  91. ncbi alpha-Hydroxy and alpha-amino acids under possible Hadean, volcanic origin-of-life conditions
    Claudia Huber
    Department of Organic Chemistry and Biochemistry, Technische Universitat Munchen, Lichtenbergstrasse 4, D 85747 Garching, Germany
    Science 314:630-2. 2006
    ..Calcium or magnesium hydroxide was added as a pH buffer. The results narrow the gap between biochemistry and volcanic geochemistry and open a new gateway for the exploration of a volcanic, hydrothermal origin of life...
  92. ncbi Water splitting goes au naturel
    Joe Alper
    Science 299:1686-7. 2003
  93. ncbi The crystal structure of [Fe]-hydrogenase reveals the geometry of the active site
    Seigo Shima
    Max Planck Institut für Terrestrische Mikrobiologie and Laboratorium für Mikrobiologie, Fachbereich Biologie, Philipps Universitat Marburg, Karl von Frisch Strasse, D 35043 Marburg, Germany
    Science 321:572-5. 2008
    ..This finding may stimulate the ongoing synthesis of catalysts that could substitute for platinum in applications such as fuel cells...
  94. ncbi Cooperativity of cytochrome P450 1A2: interactions of 1,4-phenylene diisocyanide and 1-isopropoxy-4-nitrobenzene
    Emre M Isin
    Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232 0146, USA
    Arch Biochem Biophys 473:69-75. 2008
    ..Consistent with this view, Ph(NC)2 inhibited the oxidation of 1-isopropoxy-4-nitrobenzene and other substrates...
  95. ncbi Distal heme pocket regulation of ligand binding and stability in soybean leghemoglobin
    Suman Kundu
    Department of Biochemistry, Biophysics, and Molecular Biology, Iowa State University, Ames, Iowa 50011, USA
    Proteins 50:239-48. 2003
    ..Thus, the leghemoglobin distal heme pocket provides a much lower barrier to oxygen association than occurs in myoglobin and oxygen dissociation is regulated from the proximal heme pocket...
  96. ncbi Ethylene biosynthesis by 1-aminocyclopropane-1-carboxylic acid oxidase: a DFT study
    Arianna Bassan
    Department of Physics, Stockholm Center for Physics, Astronomy and Biotechnology, Stockholm University, 10691 Stockholm, Sweden
    Chemistry 12:8835-46. 2006
    ..The reaction is assisted by bicarbonate located in the second coordination sphere of the metal...
  97. ncbi Structural bases for heme binding and diatomic ligand recognition in truncated hemoglobins
    Mario Milani
    Institute Giannina Gaslini, Largo Giannina Gaslini 5, 16147 Genova, Italy
    J Inorg Biochem 99:97-109. 2005
    ..e., O2, CO, NO, and cyanide), albeit with varying thermodynamic and kinetic parameters. Here, structural bases for heme binding and diatomic ligand recognition by trHbs are reviewed...
  98. ncbi cis-Dicyanoosmium(II) diimine complexes bearing phosphine or sulfoxide ligands: spectroscopic and luminescent studies
    Siu Wai Lai
    Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Hong Kong SAR, China
    Inorg Chem 46:11003-16. 2007
    ..The crystallographic and spectroscopic evidence suggests that 2c undergoes binding of Zn2+ ions via the cyano moieties...
  99. ncbi Nitrite controls the release of nitric oxide in Pseudomonas aeruginosa cd1 nitrite reductase
    Serena Rinaldo
    Dipartimento di Scienze Biochimiche A Rossi Fanelli, Sapienza Universita di Roma, p le A Moro, 5 00185 Rome, Italy
    Biochem Biophys Res Commun 363:662-6. 2007
    ..Thus we suggest that also in vivo the activity of cd1NIR is controlled by nitrite...
  100. ncbi Transient-state reduction and steady-state kinetic studies of menaquinol oxidase from Bacillus subtilis, cytochrome aa3-600 nm. Spectroscopic characterization of the steady-state species
    N R Mattatall
    Department of Biochemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada
    Biochemistry 40:13331-41. 2001
    ....
  101. ncbi Inversion of axial coordination in myoglobin to create a "proximal" ligand binding pocket
    Tadayuki Uno
    Graduate School of Pharmaceutical Sciences, Kumamoto University, Oehonmachi, Kumamoto 862 0973, Japan
    Biochemistry 42:10191-9. 2003
    ..The quadruple mutants open up new approaches for developing heme chemistry on the myoglobin scaffold...

Research Grants24

  1. Oligopyrrole-based Anion Binding Agents
    Jonathan L Sessler; Fiscal Year: 2010
    ..abstract_text> ..
  2. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  3. Tandem Cycloaddition Chemistry of 2-Azoniaheterodienes
    SCOTT DENMARK; Fiscal Year: 2007
    ..abstract_text> ..
  4. The Role of MgATP in Nitrogenase Catalysis
    John Peters; Fiscal Year: 2007
    ..abstract_text> ..
  5. Oral Yeast Carriage and Salivary Antifungal Activity
    EVA HELMERHORST; Fiscal Year: 2008
    ..The experiments outlined here will provide the basis for a better understanding of antifungal mechanisms exerted by saliva in the oral cavity. [unreadable] [unreadable] [unreadable]..
  6. Bilirubin oxidation and intracerebral hemorrhage
    Joseph Clark; Fiscal Year: 2009
    ..These studies are important because we believe that strategies designed to prevent BOXes production in the hematoma should provide a novel and beneficial therapeutic option for patients who have suffered an ICH. ..
  7. Cross-Coupling Reactions of Organosilanols
    SCOTT DENMARK; Fiscal Year: 2009
    ..Synthetic approaches to isodomoic acid H, hepatitis C viral inihibiting indole alkaloids, the salicylihalimide macrolactone oximidine II, and polyene antiviral antibiotic viridenomycin are detailed. ..
  8. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  9. Inhibitors of Hedgehog Signaling For Brain Cancer Chemotherapy
    JEFFREY D contact WINKLER; Fiscal Year: 2010
    ..The studies outlined herein therefore hold the promise of developing important new tools in cancer biology and new drug candidates for the treatment of brain cancers. ..
  10. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  11. Creatine Transport Across the Blood Brain Barrier
    Joseph Clark; Fiscal Year: 2006
    ..The goal for Hypothesis 2 is to develop methods and drugs to improve brain energy metabolism by getting creatine into the brain. ..
  12. Generation and Repair of an Unusual UV Photoproduct
    Joan Broderick; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  13. Biochemical Mechanisms of Vasospasms
    Joseph Clark; Fiscal Year: 2003
    ..The ultimate long-term goal for this project is to define the molecular causes of vasospasm in order to develop effective diagnostic, therapeutic and preventative approaches for this cerebral vascular disease. ..
  14. Vinylogous Amide Photochemistry in Organic Synthesis
    Jeffrey Winkler; Fiscal Year: 2005
    ..abstract_text> ..
  15. Regulation of Myeloperoxidase Catalysis by Nitric Oxide
    HUSAM ABU SOUD; Fiscal Year: 2004
    ..Studies of MPO catalytic mechanisms and function are essential to a more fundamental understanding of the factors which govern MPO-dependent processes in human health and disease. ..
  16. STRUCTURAL AND DYNAMIC STUDY OF MODEL HEME COMPLEXES
    GERD LA MAR; Fiscal Year: 2004
    ..abstract_text> ..
  17. BIOCHEMICAL MODEL REACTIONS
    Ronald Breslow; Fiscal Year: 2007
    ..In addition, both parts of the project will help us understand natural enzymes. [unreadable] [unreadable]..
  18. Synthesis of Bioactive Substances
    Jeffrey Winkler; Fiscal Year: 2003
    ..abstract_text> ..
  19. Medicinal Inorganic Chemistry ACS Symposium F-2003
    Jonathan Sessler; Fiscal Year: 2003
    ..It is thus expected that the present MIC-ACS symposium will afford a unique opportunity to develop further growth in a field of study that is rich in opportunity and central to the NIH mission. ..
  20. Electronic/Molecular Structure of Enzyme Heme Pockets
    GERD LA MAR; Fiscal Year: 2009
    ..The elucidation of the similarities and differences between bacterial and mammalian heme oxygenase will improve prospects for the design of selective inhibitors for the enzyme in pathogenic bacteria. ..
  21. Biochemical Mechanisms of Cerebral Vasospasm
    Joseph Clark; Fiscal Year: 2005
    ....
  22. Developing antibodies to diagnose cerebral vasospasm
    Joseph Clark; Fiscal Year: 2003
    ..These data will provide proof of concept that antibodies against BOXes can be used to diagnose and predict vasospasm in SAH patients. ..
  23. Functional active-site models of cytochrome c oxidase
    JAMES COLLMAN; Fiscal Year: 2009
    ..The role that the copper ion (CuB) and a phenolic group, in the amino acid tyrosine (Tyr244) play in the catalytic function of CcO are of particular interest. ..
  24. Biomimetic Studies of NO-binding Respiratory Chain Hemes
    JAMES COLLMAN; Fiscal Year: 2008
    ..An emphasis will be placed on kinetic and mechanistic studies to elucidate the putitive reaction pathways of CcO and NOR. ..