silicon dioxide

Summary

Summary: Transparent, tasteless crystals found in nature as agate, amethyst, chalcedony, cristobalite, flint, sand, QUARTZ, and tridymite. The compound is insoluble in water or acids except hydrofluoric acid.

Top Publications

  1. ncbi Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs
    Jie Lu
    Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Small 3:1341-6. 2007
  2. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
  3. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
  4. ncbi Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    Igor I Slowing
    Department of Chemistry and US Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    Adv Drug Deliv Rev 60:1278-88. 2008
  5. ncbi In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility
    Tobias J Brunner
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Environ Sci Technol 40:4374-81. 2006
  6. ncbi Targeting of porous hybrid silica nanoparticles to cancer cells
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 2500 Turku, Finland
    ACS Nano 3:197-206. 2009
  7. ncbi Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells
    Yang Li
    Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China
    Toxicol In Vitro 25:1343-52. 2011
  8. ncbi Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles
    Tianlong Liu
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No 29, East Road, Zhongguancun, Beijing 100190, PR China
    Biomaterials 33:2399-407. 2012
  9. ncbi Mesoporous silica nanoparticles in biomedical applications
    Zongxi Li
    California NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, California 90095, USA
    Chem Soc Rev 41:2590-605. 2012
  10. ncbi Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions
    Laura K Adams
    Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, USA
    Water Res 40:3527-32. 2006

Detail Information

Publications394 found, 100 shown here

  1. ncbi Mesoporous silica nanoparticles as a delivery system for hydrophobic anticancer drugs
    Jie Lu
    Department of Microbiology, Immunology, and Molecular Genetics, California NanoSystems Institute, JCCC, University of California, Los Angeles, 609 Charles E Young Drive East, Los Angeles, CA 90095, USA
    Small 3:1341-6. 2007
  2. pmc The Nalp3 inflammasome is essential for the development of silicosis
    SUZANNE L CASSEL
    Division of Allergy and Immunology, Department of Internal Medicine, University of Iowa, Iowa City, IA 52242, USA
    Proc Natl Acad Sci U S A 105:9035-40. 2008
    ..This study demonstrates a key role for the Nalp3 inflammasome in the pathogenesis of pneumoconiosis...
  3. pmc Nanoparticles activate the NLR pyrin domain containing 3 (Nlrp3) inflammasome and cause pulmonary inflammation through release of IL-1α and IL-1β
    Amir S Yazdi
    Department of Biochemistry, University of Lausanne, CH 1066 Epalinges, Switzerland
    Proc Natl Acad Sci U S A 107:19449-54. 2010
    ..The current use of nano-TiO(2) may present a health hazard due to its capacity to induce IL-1R signaling, a situation reminiscent of inflammation provoked by asbestos exposure...
  4. ncbi Mesoporous silica nanoparticles as controlled release drug delivery and gene transfection carriers
    Igor I Slowing
    Department of Chemistry and US Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    Adv Drug Deliv Rev 60:1278-88. 2008
    ..We envision that these MSN-based systems have a great potential for a variety of drug delivery applications, such as the site-specific delivery and intracellular controlled release of drugs, genes, and other therapeutic agents...
  5. ncbi In vitro cytotoxicity of oxide nanoparticles: comparison to asbestos, silica, and the effect of particle solubility
    Tobias J Brunner
    Institute for Chemical and Bioengineering, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Environ Sci Technol 40:4374-81. 2006
    ..While in vitro experiments may never replace in vivo studies, the relatively simple cytotoxic tests provide a readily available pre-screening method...
  6. ncbi Targeting of porous hybrid silica nanoparticles to cancer cells
    Jessica M Rosenholm
    Center for Functional Materials, Department of Physical Chemistry, Abo Akademi University, Porthansgatan 3 5, FI 2500 Turku, Finland
    ACS Nano 3:197-206. 2009
    ..In addition, the biospecifically tagged hybrid PEI-silica particles were shown to be noncytotoxic and able to specifically target folate receptor-expressing cancer cells also under coculture conditions...
  7. ncbi Size-dependent cytotoxicity of amorphous silica nanoparticles in human hepatoma HepG2 cells
    Yang Li
    Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China
    Toxicol In Vitro 25:1343-52. 2011
    ....
  8. ncbi Pathological mechanisms of liver injury caused by continuous intraperitoneal injection of silica nanoparticles
    Tianlong Liu
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No 29, East Road, Zhongguancun, Beijing 100190, PR China
    Biomaterials 33:2399-407. 2012
    ..These suggest that the mechanism of liver damage caused by SNs is in consonance with the occurrence of silicosis. These findings may provide useful information for the further toxicity and bioapplication research of nanoparticles...
  9. ncbi Mesoporous silica nanoparticles in biomedical applications
    Zongxi Li
    California NanoSystems Institute and Department of Chemistry and Biochemistry, University of California, 607 Charles E Young Drive East, Los Angeles, California 90095, USA
    Chem Soc Rev 41:2590-605. 2012
    ....
  10. ncbi Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions
    Laura K Adams
    Department of Civil and Environmental Engineering, Rice University, Houston, TX 77005, USA
    Water Res 40:3527-32. 2006
    The potential eco-toxicity of nanosized titanium dioxide (TiO(2)), silicon dioxide (SiO(2)), and zinc oxide (ZnO) water suspensions was investigated using Gram-positive Bacillus subtilis and Gram-negative Escherichia coli as test ..
  11. pmc The nanosilica hazard: another variable entity
    Dorota Napierska
    Unit of Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Part Fibre Toxicol 7:39. 2010
    ....
  12. ncbi Silica and titanium dioxide nanoparticles cause pregnancy complications in mice
    Kohei Yamashita
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka 565 0871, Japan
    Nat Nanotechnol 6:321-8. 2011
    ..These detrimental effects are linked to structural and functional abnormalities in the placenta on the maternal side, and are abolished when the surfaces of the silica nanoparticles are modified with carboxyl and amine groups...
  13. pmc Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
    Miriam Benezra
    Department of Radiology, Sloan Kettering Institute for Cancer Research, New York, New York 10065, USA
    J Clin Invest 121:2768-80. 2011
    ....
  14. pmc Amorphous silica nanoparticles trigger nitric oxide/peroxynitrite imbalance in human endothelial cells: inflammatory and cytotoxic effects
    J Jose Corbalan
    School of Pharmacy and Pharmaceutical Sciences, Faculty of Health Sciences, Panoz Institute, Trinity College Dublin, Dublin, Ireland
    Int J Nanomedicine 6:2821-35. 2011
    ..The purpose of this study was to investigate the mechanism of noxious effects of amorphous silica nanoparticles on human endothelial cells...
  15. ncbi The comparative effects of mesoporous silica nanoparticles and colloidal silica on inflammation and apoptosis
    Soyoung Lee
    Laboratory of Immunotoxicology, Department of Pharmacology, School of Medicine, Kyungpook National University, 101 Dong In, Jung Gu, Daegu 700 422, Republic of Korea
    Biomaterials 32:9434-43. 2011
    ..The MPS nanoparticles exhibit better biocompatibility than colloidal silica and promise excellent potential usage in the field of biomedical and biotechnological applications...
  16. ncbi Cellular uptake, cytotoxicity, and innate immune response of silica-titania hollow nanoparticles based on size and surface functionality
    Wan Kyu Oh
    School of Chemical and Biological Engineering, Seoul National University, 599 Gwanangro, Gwanak Gu, Seoul 151 742, Korea
    ACS Nano 4:5301-13. 2010
    ..These findings provide size- and surface functionality-dependent nanotoxicity and uptake of HNPs, and lead to HNPs for bioapplications such as drug delivery and imaging probe...
  17. ncbi Activation of the inflammasome by amorphous silica and TiO2 nanoparticles in murine dendritic cells
    Meike Winter
    Molecular Immunology, Institut für Umweltmedizinische Forschung at the Heinrich Heine University, Dusseldorf, Germany
    Nanotoxicology 5:326-40. 2011
    ....
  18. ncbi Mesoporous silica nanoparticles for intracellular delivery of membrane-impermeable proteins
    Igor I Slowing
    Department of Chemistry, U S DOE Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    J Am Chem Soc 129:8845-9. 2007
    ....
  19. ncbi Mesoporous silica nanoparticles: synthesis, biocompatibility and drug delivery
    Fangqiong Tang
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    Adv Mater 24:1504-34. 2012
    ..We conclude with our personal perspectives on the directions in which future work in this field might be focused...
  20. pmc Inflammatory and cytotoxic responses of an alveolar-capillary coculture model to silica nanoparticles: comparison with conventional monocultures
    Jennifer Kasper
    University Medical Centre, Institute of Pathology, Mainz, Germany
    Part Fibre Toxicol 8:6. 2011
    ....
  21. ncbi Chemistry of aqueous silica nanoparticle surfaces and the mechanism of selective peptide adsorption
    Siddharth V Patwardhan
    Interdisciplinary Biomedical Research Centre, School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK
    J Am Chem Soc 134:6244-56. 2012
    ..Follow-on questions about the relation between peptide adsorption on silica nanoparticles and mineralization of silica from peptide-stabilized precursors are raised...
  22. pmc In vitro cytotoxicity and induction of apoptosis by silica nanoparticles in human HepG2 hepatoma cells
    Xun Lu
    Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai, People s Republic of China
    Int J Nanomedicine 6:1889-901. 2011
    ..Silica nanoparticles have been discovered to exert cytotoxicity and induce apoptosis in normal human cells. However, until now, few studies have investigated the cytotoxicity of silica nanoparticles in tumor cells...
  23. ncbi In vitro toxicity of silica nanoparticles in human lung cancer cells
    Weisheng Lin
    Department of Chemistry and Environmental Research Center, University of Missouri Rolla, Rolla, MO 65409, USA
    Toxicol Appl Pharmacol 217:252-9. 2006
    ..In summary, exposure to SiO(2) nanoparticles results in a dose-dependent cytotoxicity in cultural human bronchoalveolar carcinoma-derived cells that is closely correlated to increased oxidative stress...
  24. ncbi Apoptosis induction by silica nanoparticles mediated through reactive oxygen species in human liver cell line HepG2
    Javed Ahmad
    Department of Zoology, College of Science, King Saud University, Saudi Arabia
    Toxicol Appl Pharmacol 259:160-8. 2012
    ..This study suggests that toxicity mechanisms of silica nanoparticles should be further investigated at in vivo level...
  25. pmc Adverse effect of nano-silicon dioxide on lung function of rats with or without ovalbumin immunization
    Bing Han
    Laboratory of Environmental Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Huazhong Normal University, Wuhan, China
    PLoS ONE 6:e17236. 2011
    ..For the first time, this work investigates the relationship between allergic asthma and nanosized silicon dioxide (nano-SiO₂).
  26. ncbi The effect of surface modification of amorphous silica particles on NLRP3 inflammasome mediated IL-1beta production, ROS production and endosomal rupture
    Tomohiro Morishige
    Laboratory of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 31:6833-42. 2010
    ..Our results reveal a part of NLRP3 activation pathway and provide basic information that should help to create safe and effective forms of SPs...
  27. ncbi Biodistribution and toxicity of intravenously administered silica nanoparticles in mice
    Guangping Xie
    Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China
    Arch Toxicol 84:183-90. 2010
    ....
  28. ncbi Silica nanoparticles as promising drug/gene delivery carriers and fluorescent nano-probes: recent advances
    Yiyao Liu
    Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, Sichuan, P R China
    Curr Cancer Drug Targets 11:156-63. 2011
    ....
  29. ncbi Uptake and intracellular localization of submicron and nano-sized SiO₂ particles in HeLa cells
    Marco Al-Rawi
    Karlsruhe Institute of Technology, Institute of Toxicology and Genetics, Eggenstein Leopoldshafen, Germany
    Arch Toxicol 85:813-26. 2011
    ..No accumulation of SiO(2) particles in nuclei or mitochondria of HeLa cells could be observed. In contrast to SiO(2)-SMPs, SiO(2)-NPs are preferentially localized in lysosomes...
  30. pmc SiO2 nanoparticles induce cytotoxicity and protein expression alteration in HaCaT cells
    Xifei Yang
    Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Centre for Disease Control and Prevention, NO, 21, Road 1st Tianbei, Luohu District, Shenzhen, 518020, PR China
    Part Fibre Toxicol 7:1. 2010
    Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain ..
  31. pmc The targeted delivery of multicomponent cargos to cancer cells by nanoporous particle-supported lipid bilayers
    Carlee E Ashley
    Center for Micro Engineered Materials, University of New Mexico, Albuquerque, New Mexico 87131, USA
    Nat Mater 10:389-97. 2011
    ....
  32. ncbi Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles
    Christie M Sayes
    DuPont Haskell Laboratory for Health and Environmental Sciences, Newark, Delaware 19714, USA
    Toxicol Sci 97:163-80. 2007
    ..It seems clear that in vitro cellular systems will need to be further developed, standardized, and validated (relative to in vivo effects) in order to provide useful screening data on the relative toxicity of inhaled particle types...
  33. ncbi Oxidative stress and pro-inflammatory responses induced by silica nanoparticles in vivo and in vitro
    Eun Jung Park
    College of Pharmacy, Dongduk Women s University, 23 1 Wolgok Dong, Seongbuk gu, Seoul 136 714, Republic of Korea
    Toxicol Lett 184:18-25. 2009
    ..These results suggested that silica nanoparticles generate ROS and the generated ROS may trigger the pro-inflammatory responses both in vivo and in vitro...
  34. pmc Organically modified silica nanoparticles are biocompatible and can be targeted to neurons in vivo
    Farda Barandeh
    Department of Biological Sciences, The State University of New York at Buffalo, Buffalo, New York, United States of America
    PLoS ONE 7:e29424. 2012
    ..Our results in Drosophila indicate that these novel silica based nanoparticles are biocompatible and not toxic to whole organisms, and has potential for the development of long-term applications...
  35. ncbi Nuclear-targeted drug delivery of TAT peptide-conjugated monodisperse mesoporous silica nanoparticles
    Limin Pan
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding Xi Road, Shanghai 200050, China
    J Am Chem Soc 134:5722-5. 2012
    ..This study may provide an effective strategy for the design and development of cell-nuclear-targeted drug delivery...
  36. ncbi Interaction of mesoporous silica nanoparticles with human red blood cell membranes: size and surface effects
    Yannan Zhao
    Department of Chemistry, U S Department of Energy Ames Laboratory, Iowa State University, Ames, Iowa 50011 3111, USA
    ACS Nano 5:1366-75. 2011
    ....
  37. ncbi Toxicity of amorphous silica nanoparticles on eukaryotic cell model is determined by particle agglomeration and serum protein adsorption effects
    Daniela Drescher
    BAM Federal Institute for Materials Research and Testing, Richard Willstätter Str 11, 12489 Berlin, Germany
    Anal Bioanal Chem 400:1367-73. 2011
    ..This result has implications for the evaluation of the cytotoxic potential of silica nanoparticles and possibly also other nanomaterials in standard cell culture...
  38. pmc Aspect ratio determines the quantity of mesoporous silica nanoparticle uptake by a small GTPase-dependent macropinocytosis mechanism
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, United States
    ACS Nano 5:4434-47. 2011
    ....
  39. ncbi The effect of surface charge on the uptake and biological function of mesoporous silica nanoparticles in 3T3-L1 cells and human mesenchymal stem cells
    Tsai Hua Chung
    Stem Cell Research Center, National Health Research Institutes, Miaoli 350, Taiwan, ROC
    Biomaterials 28:2959-66. 2007
    ..Our results show that MSNs uptake by hMSCs can be regulated by a threshold of positive surface charge but also imply that the modulation of surface charge on MSNs uptake is specific to cell type...
  40. ncbi Cytotoxicity and mitochondrial damage caused by silica nanoparticles
    Lei Sun
    Department of Toxicology, School of Public Health, Jilin University, Changchun, Jilin 130021, PR China
    Toxicol In Vitro 25:1619-29. 2011
    ..Mitochondrial damage was related to the oxidative stress and the direct injurious effect of nanoparticles. It can be considered as the potential mechanism for the cytotoxic effects of amorphous silica nanoparticles...
  41. ncbi Highly specific dual enzyme-mediated payload release from peptide-coated silica particles
    Paul D Thornton
    School of Chemical Sciences, Dublin City University, Dublin 9, Ireland
    J Am Chem Soc 132:2024-8. 2010
    ..Specific enzymatic hydrolysis of the peptide shell removes the bulky peptide-terminated Fmoc groups, permitting the selective release of previously entrapped guest molecules...
  42. ncbi Size-dependent cytotoxicity of monodisperse silica nanoparticles in human endothelial cells
    Dorota Napierska
    Laboratory of Lung Toxicology, Katholieke Universiteit Leuven, Herestraat 49, 3000 Leuven, Belgium
    Small 5:846-53. 2009
    ..The surface area of the tested particles is an important parameter in determining the toxicity of monodisperse amorphous silica nanoparticles...
  43. ncbi Integrated metabonomics analysis of the size-response relationship of silica nanoparticles-induced toxicity in mice
    Xiaoyan Lu
    Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, People s Republic of China
    Nanotechnology 22:055101. 2011
    ..The results suggest that not only nano-sized but also submicro-sized SP can cause similar extents of liver injury, which is dependent on the exposure dose, and the mechanism of toxicity may be almost the same...
  44. ncbi Single and repeated dose toxicity of mesoporous hollow silica nanoparticles in intravenously exposed mice
    Tianlong Liu
    Laboratory of Controllable Preparation and Application of Nanomaterials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, No 2 Beiyitiao Zhongguancun, Beijing 100190, China
    Biomaterials 32:1657-68. 2011
    ..These findings would be useful for future development of nanotechnology-based drug delivery system and other biomedical applications...
  45. ncbi Polycationic peptides from diatom biosilica that direct silica nanosphere formation
    N Kroger
    Lehrstuhl Biochemie I, Universitat Regensburg, 93053 Regensburg, Germany
    Science 286:1129-32. 1999
    ..The second lysine was identified as epsilon-N,N-dimethyl-lysine. These modifications drastically influence the silica-precipitating activity of silaffins...
  46. pmc In vivo biodistribution and clearance studies using multimodal organically modified silica nanoparticles
    Rajiv Kumar
    Institute for Lasers, Photonics and Biophotonics, The State University of New York at Buffalo, Buffalo, NY 14260, USA
    ACS Nano 4:699-708. 2010
    ..The results demonstrate that these multimodal nanoparticles have potentially ideal attributes for use as biocompatible probes for in vivo imaging...
  47. ncbi Systemic distribution, nuclear entry and cytotoxicity of amorphous nanosilica following topical application
    Hiromi Nabeshi
    Department of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biomaterials 32:2713-24. 2011
    ..Our information indicated that further studies of relation between physicochemical properties and biological responses are needed for the development and the safer form of NMs...
  48. ncbi Nano-SiO2 induces apoptosis via activation of p53 and Bax mediated by oxidative stress in human hepatic cell line
    Yiyi Ye
    State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China
    Toxicol In Vitro 24:751-8. 2010
    ..In conclusion, ROS-mediated oxidative stress, the activation of p53 and up-regulation of Bax/Bcl-2 ratio are involved in mechanistic pathways of 21 nm SiO(2) induced apoptosis in L-02 cells...
  49. ncbi Neurotoxicity of silica nanoparticles: brain localization and dopaminergic neurons damage pathways
    Jie Wu
    Shanghai Biomaterials Research and Testing Center, Shanghai Key Laboratory of Stomatology, Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200023, China
    ACS Nano 5:4476-89. 2011
    ..There is potential concern with SiO(2)-NPs' neurotoxicity in biomedical applications and occupational exposure in large-scale production...
  50. ncbi The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles
    Minjung Cho
    Division of Toxicologic Pathology, National Institute of Toxicological Research, Korea Food and Drug Administration, 231 Jinhongno Enpyung ku, Seoul 122 704, Republic of Korea
    Toxicol Lett 189:177-83. 2009
    ..Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection...
  51. ncbi Biocompatibility of calcined mesoporous silica particles with cellular bioenergetics in murine tissues
    Mariam Al Shamsi
    Department of Immunology, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, Abu Dhabi, United Arab Emirates
    Chem Res Toxicol 23:1796-805. 2010
    ..Intracellular accumulation of the particles in the studied tissues was evident by electron microscopy. The results show reasonable in vitro biocompatibility of the mesoporous silicas with murine tissue bioenergetics...
  52. ncbi Oxidative stress contributes to silica nanoparticle-induced cytotoxicity in human embryonic kidney cells
    Fen Wang
    Department of Pharmaceutics, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China
    Toxicol In Vitro 23:808-15. 2009
    ..In summary, exposure to SiO(2) nanoparticles resulted in a dose-dependent cytotoxicity in cultured HEK293 cells that was associated with increased oxidative stress...
  53. pmc Organically modified silica nanoparticles: a nonviral vector for in vivo gene delivery and expression in the brain
    Dhruba J Bharali
    Institute for Lasers, Photonics, and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260, USA
    Proc Natl Acad Sci U S A 102:11539-44. 2005
    ....
  54. pmc Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    Veit Hornung
    Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 9:847-56. 2008
    ..Our results indicate that the NALP3 inflammasome senses lysosomal damage as an endogenous 'danger' signal...
  55. ncbi Bright and stable core-shell fluorescent silica nanoparticles
    Hooisweng Ow
    Department of Materials Science and Engineering, Cornell University, Ithaca, New York 14853, USA
    Nano Lett 5:113-7. 2005
    ..This raises the possibility of tuning nanoparticle structure toward enhanced radiative properties, making them an attractive material platform for a diverse range of applications...
  56. ncbi Bifunctional magnetic silica nanoparticles for highly efficient human stem cell labeling
    Chen Wen Lu
    Center for Nanomedicine Research and Stem Cell Research Center, National Health Research Institutes, Miaoli 350, Taiwan
    Nano Lett 7:149-54. 2007
    ..5-T MRI imager under low incubation concentration of iron oxide, short incubation time, and low detection cell numbers at the same time...
  57. ncbi Intracellular localization and cytotoxicity of spherical mesoporous silica nano- and microparticles
    Qianjun He
    State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, P R China
    Small 5:2722-9. 2009
    ....
  58. ncbi Airway exposure to silica-coated TiO2 nanoparticles induces pulmonary neutrophilia in mice
    Elina M Rossi
    Unit of Excellence for Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland
    Toxicol Sci 113:422-33. 2010
    ..Our findings emphasize that it is vitally important to take into account in the risk assessment that alterations of nanoparticles, e.g., by surface coating, may drastically change their toxicological potential...
  59. pmc Seed mucilage improves seedling emergence of a sand desert shrub
    Xuejun Yang
    State Key Laboratory of Vegetation and Environmental Change, Institute of Botany, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e34597. 2012
    ..sphaerocephala by improving seedling emergence and reducing seedling mortality in stressful habitats of the sandy desert environment...
  60. ncbi Cardiovascular toxicity evaluation of silica nanoparticles in endothelial cells and zebrafish model
    Junchao Duan
    School of Public Health, Capital Medical University, Beijing 100069, PR China
    Biomaterials 34:5853-62. 2013
    ..In summary, our results suggest that exposure to silica nanoparticles is a possible risk factor to cardiovascular system...
  61. ncbi Differential plasma protein binding to metal oxide nanoparticles
    Zhou J Deng
    School of Biomedical Sciences, University of Queensland, Brisbane, QLD 4072, Australia
    Nanotechnology 20:455101. 2009
    ..current study investigated the binding of human plasma proteins to commercially available titanium dioxide, silicon dioxide and zinc oxide nanoparticles...
  62. ncbi Silica-based nanoparticles for biomedical applications
    Ahmad Bitar
    Universite de Lyon, F 69622, Lyon, France
    Drug Discov Today 17:1147-54. 2012
    ..In addition, they are used as safety and biocompatible pharmaceutical additives. Here, we focus on novel techniques based on silica NPs for the most important biomedical applications...
  63. pmc The use of silica coated MnO nanoparticles to control MRI relaxivity in response to specific physiological changes
    Yi Cheng Lee
    Department of Materials Science and Engineering, University of Washington, Seattle, WA 98195, USA
    Biomaterials 33:3560-7. 2012
    ..The delayed enhancement may have benefits for targeting MRI contrast to specific cells and surface receptors that are known to be recycled by endocytosis...
  64. ncbi Nominal and effective dosimetry of silica nanoparticles in cytotoxicity assays
    Dominique Lison
    Industrial Toxicology and Occupational Medicine Unit, Universite Catholique de Louvain, Avenue E Mounier 53 02, 1200 Brussels, Belgium
    Toxicol Sci 104:155-62. 2008
    ..This observation has important bearings on the experimental design and the interpretation of in vitro toxicological studies with nanoparticles...
  65. pmc In Caenorhabditis elegans nanoparticle-bio-interactions become transparent: silica-nanoparticles induce reproductive senescence
    Adam Pluskota
    Institut für umweltmedizinische Forschung IUF at Heinrich Heine University Düsseldorf, Dusseldorf, Germany
    PLoS ONE 4:e6622. 2009
    ....
  66. ncbi Bio-silica and bio-polyphosphate: applications in biomedicine (bone formation)
    Xiaohong Wang
    ERC Advanced Grant Research Group at the Institute for Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, Duesbergweg 6, D 55128 Mainz, Germany
    Curr Opin Biotechnol 23:570-8. 2012
    ....
  67. ncbi The packaging of siRNA within the mesoporous structure of silica nanoparticles
    Xu Li
    Nano Biomedical Research Center, School of Biomedical Engineering and Med X Research Institute, Shanghai Jiao Tong University, Shanghai 200030, China
    Biomaterials 32:9546-56. 2011
    ..In summary, our siRNA packaging strategy extends the application potential of M-MSNs and the resulting siRNA delivery vehicles can be further tested for in vivo experiments...
  68. ncbi Oxygen-aided synthesis of polycrystalline graphene on silicon dioxide substrates
    Jianyi Chen
    Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China
    J Am Chem Soc 133:17548-51. 2011
    We report the metal-catalyst-free synthesis of high-quality polycrystalline graphene on dielectric substrates [silicon dioxide (SiO(2)) or quartz] using an oxygen-aided chemical vapor deposition (CVD) process...
  69. ncbi Formation of nucleoplasmic protein aggregates impairs nuclear function in response to SiO2 nanoparticles
    Min Chen
    Institut für umweltmedizinische Forschung IUF at Heinrich Heine University Düsseldorf, Auf m Hennekamp 50, D 40225 Dusseldorf, Germany
    Exp Cell Res 305:51-62. 2005
    ....
  70. ncbi Effect of zirconium-oxide ceramic surface treatments on the bond strength to adhesive resin
    Saadet Saglam Atsu
    Department of Prosthodontics, Kirikkale University, Faculty of Dental Medicine, Turkey
    J Prosthet Dent 95:430-6. 2006
    ..Surface treatment methods used for resin bonding to conventional silica-based dental ceramics are not reliable for zirconium-oxide ceramics...
  71. ncbi Position-specific chemical modification and quantitative proteomics disclose protein orientation adsorbed on silica nanoparticles
    Siddhartha Shrivastava
    Rensselaer Nanotechnology Center, Rensselaer Polytechnic Institute, Troy, New York 12180, USA
    Nano Lett 12:1583-7. 2012
    ..These results suggest that nanoparticle size and protein structure influence protein orientation on SNPs...
  72. ncbi Comparative cytological responses of lung epithelial and pleural mesothelial cells following in vitro exposure to nanoscale SiO2
    J Michael Berg
    Interdisciplinary Toxicology, MS 4466, Texas A and M University, College Station, TX 77843, United States
    Toxicol In Vitro 27:24-33. 2013
    ..Results indicated that, while both cell types exhibited susceptibility to H(2)O(2) and SiO(2)-induced oxidative stress and damage, the A549 cell line was relatively more resilient...
  73. pmc Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 3:3273-86. 2009
    ..This novel use of a cationic MSNP extends its therapeutic use potential...
  74. ncbi Controlled intracellular release of doxorubicin in multidrug-resistant cancer cells by tuning the shell-pore sizes of mesoporous silica nanoparticles
    Yu Gao
    Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Shanghai 201203, People s Republic of China
    ACS Nano 5:9788-98. 2011
    ..These results demonstrate that HMSNs could be a very promising drug delivery system for pore-size-controllable drug release and cancer MDR reversion...
  75. ncbi Uniform mesoporous dye-doped silica nanoparticles decorated with multiple magnetite nanocrystals for simultaneous enhanced magnetic resonance imaging, fluorescence imaging, and drug delivery
    Ji Eun Lee
    National Creative Research Initiative Center for Oxide Nanocrystalline Materials, and School of Chemical and Biological Engineering, Seoul National University, Seoul 151 744, Korea
    J Am Chem Soc 132:552-7. 2010
    ....
  76. ncbi Towards multifunctional, targeted drug delivery systems using mesoporous silica nanoparticles--opportunities & challenges
    Jessica M Rosenholm
    Department of Physical Chemistry, Abo Akademi University, Center for Functional Materials, Porthansgatan 3 5, FI 20500 Turku, Finland
    Nanoscale 2:1870-83. 2010
    ..Addressing these burning questions will facilitate the application of MSNs in nanomedicine...
  77. pmc Use of size and a copolymer design feature to improve the biodistribution and the enhanced permeability and retention effect of doxorubicin-loaded mesoporous silica nanoparticles in a murine xenograft tumor model
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California, United States
    ACS Nano 5:4131-44. 2011
    ..Further endowment of this multifunctional drug delivery platform with targeting ligands and nanovalves may further enhance cell-specific targeting and on-demand release...
  78. ncbi Mesoporous silica nanoparticles for intracellular controlled drug delivery
    Juan L Vivero-Escoto
    Department of Chemistry and U S Department of Energy, Ames Laboratory, Iowa State University, Ames, IA 50011 3111, USA
    Small 6:1952-67. 2010
    ..Finally, the latest breakthroughs for intracellular controlled drug release using stimuli-responsive mesoporous-silica-based systems are described...
  79. ncbi Synthesis of large-area MoS2 atomic layers with chemical vapor deposition
    Yi Hsien Lee
    Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan
    Adv Mater 24:2320-5. 2012
    ..Optical, microscopic and electrical measurements suggest that the synthetic process leads to the growth of MoS(2) monolayer. The TEM images verify that the synthesized MoS(2) sheets are highly crystalline...
  80. ncbi Amorphous nanosilicas induce consumptive coagulopathy after systemic exposure
    Hiromi Nabeshi
    Laboratory of Toxicology and Safety Science, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan
    Nanotechnology 23:045101. 2012
    ..These results would provide useful information for ensuring the safety of nanomaterials (NMs) and open new frontiers in biological fields by the use of NMs...
  81. ncbi Zwitteration as an alternative to PEGylation
    Zaki G Estephan
    Department of Chemistry and Biochemistry, Florida State University, Tallahassee, Florida 32306, United States
    Langmuir 27:6794-800. 2011
    ....
  82. ncbi Presence and risks of nanosilica in food products
    Susan Dekkers
    RIVM National Institute for Public Health and the Environment, Bilthoven
    Nanotoxicology 5:393-405. 2011
    ..For the second scenario there are too many uncertainties to allow proper risk assessment. Therefore, it is recommended to prioritize research on how nanosilica is absorbed from the gastrointestinal tract...
  83. ncbi Cellular uptake, evolution, and excretion of silica nanoparticles in human cells
    Zhiqin Chu
    Department of Physics, The Chinese University of Hong Kong, Shatin, New Territory, Hong Kong
    Nanoscale 3:3291-9. 2011
    ..These interaction characteristics determine the low cytotoxicity of SiO(2) NPs at low feeding concentration...
  84. pmc Nanopatterned protein microrings from a diatom that direct silica morphogenesis
    André Scheffel
    School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332, USA
    Proc Natl Acad Sci U S A 108:3175-80. 2011
    ....
  85. ncbi Comparison of exposure assessment methods for occupational carcinogens in a multi-centre lung cancer case-control study
    Susan Peters
    Institute for Risk Assessment Sciences, Environmental Epidemiology Division, Utrecht University, Utrecht, The Netherlands
    Occup Environ Med 68:148-53. 2011
    ..Different methods have been developed, including case-by-case expert assessment and job-exposure matrices (JEM). The present analyses compare exposure prevalence and risk estimates derived by different exposure assessment methods...
  86. ncbi Silica nanoparticle coated liposomes: a new type of hybrid nanocapsule for proteins
    Vellore J Mohanraj
    Ian Wark Research Institute, The ARC Special Research Centre for Particle and Material Interfaces, University of South Australia, Mawson Lakes, SA 5095, Australia
    Int J Pharm 392:285-93. 2010
    ..Silica nanoparticle-liposomes hybrid nanocapsules show promise as a delivery vehicle for proteins and peptides...
  87. pmc Mesoporous silica nanoparticles as drug delivery systems for targeted inhibition of Notch signaling in cancer
    Veronika Mamaeva
    Turku Centre for Biotechnology, University of Turku and Abo Akademi University, Turku, Finland
    Mol Ther 19:1538-46. 2011
    ..The data highlights MSNPs as an attractive platform for targeted drug delivery of anticancer drugs with otherwise restricted clinical application, and as interesting constituents in the quest for more refined Notch therapies...
  88. pmc Activation of stress-related signalling pathway in human cells upon SiO2 nanoparticles exposure as an early indicator of cytotoxicity
    Bashir Mustafa Mohamed
    Department of Clinical Medicine, Institute of Molecular Medicine, Trinity College Dublin, Dublin 8, Ireland
    J Nanobiotechnology 9:29. 2011
    ..Thus, a mechanistic and systematic evaluation of the potential biological and toxic effects of SiO2NP becomes crucial in order to assess their complete safe applicability limits...
  89. ncbi Cluster randomized controlled trial of the plastic BioSand Water filter in Cambodia
    C E Stauber
    Institute of Public Health, Georgia State University, P O Box 3995, Atlanta, Georgia 30302 3995, United States
    Environ Sci Technol 46:722-8. 2012
    ..The study suggests the plastic BSF may play an important role in scaling up the distribution/implementation of the BSF, potentially improving water quality and health in the region...
  90. ncbi Silica nanoparticles as hepatotoxicants
    Hikaru Nishimori
    Laboratory of Bio Functional Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Eur J Pharm Biopharm 72:496-501. 2009
    ..Taken together, nano-size materials may be hepatotoxic, and these findings will be useful for future development in nanotechnology-based drug delivery system...
  91. ncbi Mesoporous silica as a membrane for ultra-thin implantable direct glucose fuel cells
    Tushar Sharma
    Department of Biomedical Engineering, University of Texas at Austin, Austin, TX 78712, USA
    Lab Chip 11:2460-5. 2011
    ..We demonstrate that a mesoporous silica thin film (270 nm) is capable of replacing the conventional polymer based membranes with an improvement in the power generated over conventional direct glucose fuel cells...
  92. pmc Silica binding and toxicity in alveolar macrophages
    Raymond F Hamilton
    Department of Biomedical and Pharmaceutical Sciences, Center for Environmental Health Sciences, University of Montana, 32 Campus Drive, SB 154, Missoula, MT 59812, USA
    Free Radic Biol Med 44:1246-58. 2008
    ..Current research ideas on silica toxicity and binding in the alveolar macrophage are reviewed and discussed...
  93. ncbi Reproducible comet assay of amorphous silica nanoparticles detects no genotoxicity
    Clifford A Barnes
    University of Ulster, Coleraine, United Kingdom
    Nano Lett 8:3069-74. 2008
    ....
  94. ncbi Efficient internalization of silica-coated iron oxide nanoparticles of different sizes by primary human macrophages and dendritic cells
    Andrea Kunzmann
    Division of Molecular Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Toxicol Appl Pharmacol 253:81-93. 2011
    ..We conclude that these novel silica-coated iron oxide nanoparticles are promising materials for medical imaging, cell tracking and other biomedical applications...
  95. pmc Controlling the response: predictive modeling of a highly central, pathogen-targeted core response module in macrophage activation
    Jason E McDermott
    Computational Biology and Bioinformatics, Pacific Northwest National Laboratory, Richland, Washington, United States of America
    PLoS ONE 6:e14673. 2011
    ..We speculate that this module may be an early checkpoint for progression to apoptosis and/or inflammation during macrophage activation...
  96. ncbi A mesoporous silica nanosphere-based carrier system with chemically removable CdS nanoparticle caps for stimuli-responsive controlled release of neurotransmitters and drug molecules
    Cheng Yu Lai
    Department of Chemistry, Iowa State University, Ames, IA 50011 3111, USA
    J Am Chem Soc 125:4451-9. 2003
    ..We envision that this new MSN system could play a significant role in developing new generations of site-selective, controlled-release delivery nanodevices...
  97. pmc Engineered design of mesoporous silica nanoparticles to deliver doxorubicin and P-glycoprotein siRNA to overcome drug resistance in a cancer cell line
    Huan Meng
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 4:4539-50. 2010
    ..These results demonstrate that it is possible to use the MSNP platform to effectively deliver a siRNA that knocks down gene expression of a drug exporter that can be used to improve drug sensitivity to a chemotherapeutic agent...
  98. pmc Macrophage responses to silica nanoparticles are highly conserved across particle sizes
    Katrina M Waters
    Environmental Biomarkers Program, Pacific Northwest National Laboratory, Richland, Washington 99352, USA
    Toxicol Sci 107:553-69. 2009
    ..However, our results suggest that on an equivalent nominal surface area basis, common biological modes of action are expected for nano- and supranano-sized silica particles...
  99. ncbi Functional and multifunctional nanoparticles for bioimaging and biosensing
    Subramanian Tamil Selvan
    Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602
    Langmuir 26:11631-41. 2010
    ..Using silica coated NPs, various NPs that are functionalized with antibody, oligonucleotide, biotin and dextran are efficiently used for protein detection...
  100. ncbi Silica-coated nanocomposites of magnetic nanoparticles and quantum dots
    Dong Kee Yi
    Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore 138669
    J Am Chem Soc 127:4990-1. 2005
    ..The resulting SiO2/MP-QD nanocomposite particles present a unique combination of magnetic and optical properties. Their nonporous silica shell allows them to be surface modified for bioconjugation in various biomedical applications...
  101. ncbi Optimal enhancement configuration of silica nanoparticles for ultrasound imaging and automatic detection at conventional diagnostic frequencies
    Sergio Casciaro
    Biomedical Engineering Science and Technology Division, Institute of Clinical Physiology, National Research Council, Lecce, Italy
    Invest Radiol 45:715-24. 2010
    ..We also assessed the effectiveness of a novel method for automatic detection of targeted silica nanoparticles for future tissue typing applications...

Research Grants63

  1. Optimized Growth Media to Detect Intracellular Bacteria Implicated in Chronic Dis
    PATRICIA MASCARELLI; Fiscal Year: 2011
    ..abstract_text> ..
  2. DRUG RESISTANCE AND PTERIDINE METABOLISM IN LEISHMANIA
    Stephen M Beverley; Fiscal Year: 2010
    ..These studies have yielded new opportunities for chemotherapeutic attack and new directions for future study of pteridine metabolism and biology. [unreadable] ..
  3. Role of surface proteins in sand fly colonization by Bartonella bacilliformis
    Michael F Minnick; Fiscal Year: 2013
    ..The results of the study are expected to provide a solid foundation for eventually developing control strategies designed to interrupt the sand fly-Bb association. ..
  4. P. papatasi midgut molecules: gene function and assessing TBV candidates
    JOSE MARCELO contact RAMALHO ORTIGAO; Fiscal Year: 2010
    ....
  5. GLYCOSYLATION MUTANTS OF LEISHMANIA
    Salvatore J Turco; Fiscal Year: 2012
    ..Our ultimate goal is a comprehensive understanding of the genes and gene products responsible for synthesizing Leishmania surface and secreted molecules, and their individual and specific roles in parasite virulence. ..
  6. Impact of Microparticles on Oral TSE Infections
    Joel A Pedersen; Fiscal Year: 2012
    ..We have recently demonstrated that prions bind to soil, clay minerals and silicon dioxide (Johnson et al., 2007)...
  7. Development of novel therapeutics for a neglected tropical disease leishmaniasis
    ABHAY R contact SATOSKAR; Fiscal Year: 2010
    ..The overall goal of this project is to discover novel antileishmanial drugs from the plant Pentalinon andreuxii for treating different forms of leishmaniasis. ..
  8. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2009
    ..Keywords lung burden, fibrosis, toxicity and carcinogenicity, metal working fluids, abrasive blasting agents, fullerenes, nanomaterials, artificial butter flavorings, antimony trioxide, ortho-phthalaldehyde ..
  9. ETIOLOGY AND PATHOGENESIS OF PEMPHIGUS
    Luis A Diaz; Fiscal Year: 2013
    ..In parallel, new epitope-specific immunoassays and potential novel therapeutic interventions may evolve from these studies. ..
  10. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2011
    ..Keywords lung burden, fibrosis, toxicity and carcinogenicity, metal working fluids, abrasive blasting agents, artificial butter flavorings, antimony trioxide, ortho-phthalaldehyde ..
  11. Fifth World Congress of Leishmaniasis 2013
    Lynn Soong; Fiscal Year: 2013
    ..This congress and its training opportunities will have a significant impact on the control of infectious diseases and the improvement of global health. ..
  12. Studies to Evaluate the Toxic Carcinogenic Potential of Test Agents
    JEFFERY DILL; Fiscal Year: 2010
    ..Keywords lung burden, fibrosis, toxicity and carcinogenicity, metal working fluids, abrasive blasting agents, artificial butter flavorings, antimony trioxide, ortho-phthalaldehyde ..
  13. Nucleoside hydrolase Inhibitors from natural products for Leishmania
    ESTEBAN EDWARD MENA; Fiscal Year: 2010
    ..Also, there is a concern that leishmaniasis could become more widespread in the United States. Our goal is to identify compounds that can be developed for the effective treatment of Leishmaniasis. ..
  14. Cutaneous Leishmaniasis in West Africa: the Parasite, Vector and Disease
    Seydou Doumbia; Fiscal Year: 2013
    ..Understanding of these relationship is important for vaccine development and field trials of control strategies. ..
  15. Regulation of Leishmania-Associated Macrophage Activities by MicroRNAs
    Joel W Graff; Fiscal Year: 2013
    ..The long-term goal of this project is to develop novel RNA-based therapeutics that promotes leishmanicidal activity in macrophages. ..
  16. Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
    Wally R Smith; Fiscal Year: 2013
    ....
  17. Pre-mRNA Interference of VEGF Pathways in Ocular Angiogenesis
    Balamurali K Ambati; Fiscal Year: 2013
    ..It may eventually be of relevance in helping treatment of cancer &diabetic retinopathy. ..
  18. Growth Hormone & IGF-1 in CNS and Cerebrovascular Aging
    William Edmund Sonntag; Fiscal Year: 2010
    ....
  19. ProstaFluor FDA Trial for Real-Time Margin Detection During Prostatectomy
    David A Benaron; Fiscal Year: 2013
    ..We expect that the market for such a device in cancer could reasonably be in the hundreds of millions of dollars/year. Form SF-424 Abstract ..
  20. L. major infection: Natural history and determinants of resistance
    Afif Ben Salah; Fiscal Year: 2011
    ..3. To develop and validate scales for severity of cutaneous lesions and quality of resulting scars. The scale items include size of the ulcer, color (hypopigmentation, hyperpigmentation, normal skin) and height. ..
  21. Study of cutaneous leishmaniasis in Sri Lanka caused by L.donovani
    NADIRA DHARSHANI KARUNAWEERA; Fiscal Year: 2013
    ..donovani, which in the long term would help reduce the global disease burden contributing positively towards the disease elimination efforts in the Indian subcontinent. ..
  22. Scalable Software for Reverse Engineering Neural Circuits from Histology
    CHRISTOPHER CHARLES LAW; Fiscal Year: 2013
    ..We will also implement fusion methods that will take as input the segmentation results from different algorithms and that will generate the tracings of neural processes by linking segmentation results from one section to the next. ..
  23. The role of sand fly saliva in visceralization of Leishmania parasites
    Gregory Lanzaro; Fiscal Year: 2009
    ..Finally, in Aim #3, we will evaluate the immunomodulatory properties of maxadilan variants found in natural populations of Lu. longipalpis from Brazil and Costa Rica. ..
  24. Visceral Leishmaniasis in Bihar State, India
    Shyam Sundar; Fiscal Year: 2013
    ....
  25. Nanostructured Cancer Vaccines
    T Andrew Taton; Fiscal Year: 2010
    ..We propose to fabricate Au-ringed silicon dioxide disks that will allow us to spatially arrange different APC receptors in the way they would be in a mature ..
  26. Development of Stable Isotope Based Methods to Predict Bioavailability of Hydroph
    Jay Gan; Fiscal Year: 2013
    ..abstract_text> ..
  27. Leishmania major nucleoside hydrolase inhibitors
    Claude Selitrennikoff; Fiscal Year: 2007
    ..We expect that our work will lead to new compounds with a specific and known mechanism of action that will be useful for the treatment of human leishmaniasis. [unreadable] [unreadable] [unreadable]..
  28. Biodegradable Field-Effect Transitors for Electronically Active Scaffolds
    CHRISTOPHER JOHN BETTINGER; Fiscal Year: 2010
    ..for biomedical applications have been fabricated using traditional inorganic materials such as silicon and silicon dioxide. Non-degradable polymers such as polyethylene, silicone, and polytetrafluoroethylene have also been used...
  29. Midwest Emerging Technologies Public Health and Safety Training Program
    Peter C Raynor; Fiscal Year: 2013
    ..The modules will be freely available to any instructor who wishes to use them, thus having a regional, national, and global reach. ..
  30. Biofilm Population Structure in the Gangetic Delta
    Gary Schoolnik; Fiscal Year: 2006
    ..unreadable] [unreadable]..
  31. A novel vaccine against Leishmania
    Claude Selitrennikoff; Fiscal Year: 2005
    ..We believe that this work will lead to the development of prophylactic and therapeutic vaccines against Leishmania ..
  32. New drugs for the treatment of leishmaniasis
    Claude Selitrennikoff; Fiscal Year: 2004
    ..Ultimately, this work will lead to the identification of a lead compound for human clinical trials for the treatment of leishmaniasis. ..
  33. GENETICS AND BIOGEOGRAPHY OF SANDFLY DISEASE VECTORS
    Leonard Munstermann; Fiscal Year: 2000
    ..S. and Latin America, particularly in Brazil, Colombia, Panama and Costa Rica will assist in the collection of flies and field data. ..
  34. Molecular mechanisms underlying parallel Agouti adaptation in Peromyscus
    CATHERINE LINNEN; Fiscal Year: 2009
    ..Relevance: This research is of direct relevance to the mission of NIH because it will identify and molecularly characterize Agouti mutations, which will inform current models of mammalian pigmentation and human obesity. ..
  35. Arthropod vector-based vaccines for leishmaniasis
    Richard Titus; Fiscal Year: 2009
    ..There are currently no effective ways to control these diseases. New and effective methods (especially novel vaccine approaches such as the one described here) are sorely needed. ..
  36. Phylogeography of Verrucarum sand fly disease vectors
    Leonard Munstermann; Fiscal Year: 2006
    ..abstract_text> ..
  37. MAXADILAN, A CUTANEOUS VASODILATOR FROM SAND FLIES
    Ethan Lerner; Fiscal Year: 2002
    ..Such proteins and genes will provide new tools with which to study hematologic and cardiovascular pharmacology and will lead to new therapeutic agents. ..
  38. Sorbents for Removal of Arsenic and Heavy Metals
    JOHN LOVELL; Fiscal Year: 2003
    ..abstract_text> ..
  39. Number Words and Number Concepts
    BARBARA SARNECKA; Fiscal Year: 2009
    ..Study 5 will tell us when children learn that number words refer to a property of sets rather than a property of individuals. For example, green is a property of an individual turtle, but five is a property of a set of turtles. ..
  40. Conference and Participant Support for Mtg: Statistical Analysis of Neuronal Data
    Robert E Kass; Fiscal Year: 2012
    ..The Statistical Analysis of Neural Data (SAND) meetings will continue to push neuroscience forward by encouraging young computationally-oriented researchers and by improving communication and dissemination of relevant results. ..
  41. SCORE Program at the University of the Incarnate Word
    Sara Kerr; Fiscal Year: 2004
    ..McHugh will investigate the influence of abiotic factors on population fluctuations of vectors. (4) Dr. Kerr, Dr. McHugh and Dr. Curry will develop a stochastic model that predicts temporal peaks of sand fly emergence. ..
  42. VACCINATION OF DOGS TO REDUCE TRANSMISSION OF LEISHMANIA
    Peter Melby; Fiscal Year: 2003
    ..Successful vaccination of dogs in an endemic could reduce both enzootic (among the canine reservoir) and zoonotic (from the canine reservoir to humans) transmission. ..
  43. SAND FLY AND TICK SALIVA AND DISEASE
    Richard Titus; Fiscal Year: 2002
    ....
  44. PATTERNED NEURONAL NETWORKS
    Bruce Wheeler; Fiscal Year: 1991
    ..polyimide insulation with a neural substrate of polylysine selectively ablated by laser; 2. silicon dioxide insulation with patterns of covalently bonded areas of high (diamines) and low (alkanes) adhesion...
  45. GENETIC SUSCEPTIBILITY TO VISCERAL LEISHMANIASIS
    Mary Wilson; Fiscal Year: 2002
    ..Familial aggregation, association studies, and model-free linkage studies will be conducted to determine whether genetic factors influence L. chagasi infection. ..
  46. IMPROVING HEALTH OUTCOMES IN UNPARTNERED CARDIAC ELDERS
    Sally Rankin; Fiscal Year: 2003
    ..Social support and self-efficacy are mediating variable sand will be measured by the MOS Social Support Scale and the Jenkins Self-Efficacy Expectation scales for Walking and General Activity. ..
  47. Mussel-Inspired Protective Coatings
    JOHN WAITE; Fiscal Year: 2006
    ..All films will be evaluated by macro- and nanomechanical tests, and their resistance to a diverse range of biochemical, thermal, and mechanical insults will be examined. ..
  48. EPIDEMIOLOGY AND CONTROL OF VISCERAL LEISHMANIASIS
    Robert Tesh; Fiscal Year: 1992
    ..chagasi in the endemic area. The proposed project is of four years duration and involves the fields of parasitology, medical entomology, epidemiology and public health...
  49. BioMEMS Materials for Renal Tissue Engineering
    WILLIAM FISSELL; Fiscal Year: 2004
    ..Specific Aim 1: Demonstrate attachment of porcine and human RPTCs to mono- and poly-crystalline silicon, silicon dioxide, silicon nitride, and polydimethoxysilane ("MEMS materials"), with and without extracellular matrix proteins...
  50. MULTICENTER TRIAL OF SYNSORB PK IN E COLI RELATED HUS
    Howard Trachtman; Fiscal Year: 2003
    ..SYNSORB Pk is an adsorbent agent composed of a platform molecule, diatomaceous silicon dioxide, which is covalently linked to a unique oligosaccharide chain...
  51. PREVENTIVE CARDIOLOGY ACADEMIC AWARD
    John Farquhar; Fiscal Year: 1993
    ..Lastly, a well defined on-going faculty training program will assist in the institutionalization of the preventive cardiology curriculum at Stanford...
  52. INTERPLAY OF BIOLOGICAL AND PHYSICAL PROCESSES IN OTOCONIAL MORPHOGENESIS
    Ruediger Thalmann; Fiscal Year: 2009
    ..Information gained should ultimately provide means to slow down the deleterious effects of aging on otoconia, in a manner similar to our ability to prevent and/or ameliorate dental caries or osteoporosis. ..
  53. Conference on Regulatory Myeloid Cells in Health and Diseases
    Dmitry Gabrilovich; Fiscal Year: 2009
    ..The conference will be held from March 12 through March 15 2009 at Sheraton Sand Key Resort, 1160 Gulf Bulevard, Clearwater Beach, FL 33767 located on the Pinellas Suncoast, just 21 miles west of the Tampa International Airport. ..
  54. ULTRASTRUCTURAL STUDIES--LEISHMANIA-SANDFLY INTERACTION
    LAUREL WALTERS; Fiscal Year: 1992
    ..Methodology to be used in this research project includes experimental infection of sand flies, histology and histochemistry, light and transmission electron microscopy, electron microscopic cytochemistry, and biological assays...
  55. Regulation and Development of the Prefrontal Cortex
    Suzanne Haber; Fiscal Year: 2005
    ..A specific emphasis is on recruiting young scientists to the field. Therefore each workshop will engage at least one young scientist in a leadership role, (as facilitator, scribe, or presenter). ..
  56. Conference on immune suppression in cancer
    Dmitry Gabrilovich; Fiscal Year: 2007
    ..tumor escape of immune system control; [unreadable] Review and discuss how our knowledge of new mechanisms of tumor associated immune suppression can be translated into new therapeutics [unreadable] [unreadable] [unreadable] [unreadable]..
  57. A NOVEL TARGET-BASED DRUG DEVELOPMENT PROGRAM
    Min Yang; Fiscal Year: 1999
    ..Cubist Pharmaceuticals has taken a target-based approach to the discovery of novel antibiotics. In this proposal we outline a research project that will allow us to identify inhibitors ..
  58. MEASUREMENT OF SURFACE CHARACTERISTICS FOR ACCESSIBILITY
    PETER AXELSON; Fiscal Year: 1993
    ..People with mobility limitations, designers and planners will use this information to determine the degree of accessibility of indoor and outdoor environments...
  59. MULTISPECTRAL FUNDUS IMAGING SYSTEM
    Peter Soliz; Fiscal Year: 2000
    ..As a quantitative tool for determining the efficacy of new procedures for treating ARMD, the Stereoscopic Grading System for ARMD will be offered to pharmaceuticals and researchers. ..
  60. STEREOSCOPIC GRADING SYSTEM--AGE RELATED MACULOPATHY
    Peter Soliz; Fiscal Year: 1999
    ..As a quantitative tool for determining the efficacy of new procedures for treating ARMD, the Stereoscopic Grading System for ARMD will be offered to pharmaceuticals and researchers. ..
  61. AGE RELATED CARDIAC SENSITIVITY TO VOLATILE ANESTHETICS
    Y S Prakash; Fiscal Year: 2001
    ....
  62. SAND Workshop
    Robert Kass; Fiscal Year: 2008
    ..abstract_text> ..
  63. Does ArsenicMitigation in BangladeshRaiseExposure to Bacterial and ViralPathogens
    ALEXANDER FRANS VAN GEEN; Fiscal Year: 2010
    ....