selenium

Summary

Summary: An element with the atomic symbol Se, atomic number 34, and atomic weight 78.96. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.

Top Publications

  1. ncbi Selenium and human health
    Margaret P Rayman
    Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
    Lancet 379:1256-68. 2012
  2. ncbi Characterization of mammalian selenoproteomes
    Gregory V Kryukov
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
    Science 300:1439-43. 2003
  3. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
  4. pmc Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
  5. pmc The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities
    Zhi Huang
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Antioxid Redox Signal 16:705-43. 2012
  6. ncbi Glutathione peroxidase activity in selenium-deficient rat liver
    R A Lawrence
    Biochem Biophys Res Commun 71:952-8. 1976
  7. ncbi Selenium and the course of mild Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    N Engl J Med 364:1920-31. 2011
  8. ncbi Selenium in cancer prevention: a review of the evidence and mechanism of action
    Margaret P Rayman
    Division of Nutrition, Dietetics and Food, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Proc Nutr Soc 64:527-42. 2005
  9. ncbi Selenium in human health and disease
    Susan J Fairweather-Tait
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, United Kingdom
    Antioxid Redox Signal 14:1337-83. 2011
  10. ncbi Food-chain selenium and human health: emphasis on intake
    Margaret P Rayman
    Nutritional Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Br J Nutr 100:254-68. 2008

Detail Information

Publications338 found, 100 shown here

  1. ncbi Selenium and human health
    Margaret P Rayman
    Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK
    Lancet 379:1256-68. 2012
    b>Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone...
  2. ncbi Characterization of mammalian selenoproteomes
    Gregory V Kryukov
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588 0664, USA
    Science 300:1439-43. 2003
    ..The human selenoproteome consists of 25 selenoproteins...
  3. pmc Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Scott M Lippman
    Division of Cancer Medicine, University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    JAMA 301:39-51. 2009
    Secondary analyses of 2 randomized controlled trials and supportive epidemiologic and preclinical data indicated the potential of selenium and vitamin E for preventing prostate cancer.
  4. pmc Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT)
    Eric A Klein
    Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, Ohio 44195, USA
    JAMA 306:1549-56. 2011
    The initial report of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) found no reduction in risk of prostate cancer with either selenium or vitamin E supplements but a statistically nonsignificant increase in prostate cancer ..
  5. pmc The role of selenium in inflammation and immunity: from molecular mechanisms to therapeutic opportunities
    Zhi Huang
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, USA
    Antioxid Redox Signal 16:705-43. 2012
    Dietary selenium (]Se), mainly through its incorporation into selenoproteins, plays an important role in inflammation and immunity...
  6. ncbi Glutathione peroxidase activity in selenium-deficient rat liver
    R A Lawrence
    Biochem Biophys Res Commun 71:952-8. 1976
  7. ncbi Selenium and the course of mild Graves' orbitopathy
    Claudio Marcocci
    Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy
    N Engl J Med 364:1920-31. 2011
    ..Oxygen free radicals and cytokines play a pathogenic role in Graves' orbitopathy...
  8. ncbi Selenium in cancer prevention: a review of the evidence and mechanism of action
    Margaret P Rayman
    Division of Nutrition, Dietetics and Food, School of Biomedical and Molecular Sciences, University of Surrey, Guildford, UK
    Proc Nutr Soc 64:527-42. 2005
    ..Current primary and secondary prevention trials of Se are underway in the USA, including the Selenium and Vitamin E Cancer Prevention Trial (SELECT) relating to prostate cancer, although a large European trial is ..
  9. ncbi Selenium in human health and disease
    Susan J Fairweather-Tait
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, Norfolk, United Kingdom
    Antioxid Redox Signal 14:1337-83. 2011
    This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system...
  10. ncbi Food-chain selenium and human health: emphasis on intake
    Margaret P Rayman
    Nutritional Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Br J Nutr 100:254-68. 2008
    ..The difficulties of balancing the risks and benefits in relation to Se intake are highlighted...
  11. ncbi Elemental selenium at nano size (Nano-Se) as a potential chemopreventive agent with reduced risk of selenium toxicity: comparison with se-methylselenocysteine in mice
    Jinsong Zhang
    University of Science and Technology of China, Hefei 230052, Anhui, P R China
    Toxicol Sci 101:22-31. 2008
    b>Selenium (Se) is an essential trace element with a narrow margin between beneficial and toxic effects...
  12. ncbi Selenium: a double-edged sword for defense and offence in cancer
    Jela Brozmanová
    Laboratory of Molecular Genetics, Cancer Research Institute, Vlarska 7, 833 91, Bratislava, Slovak Republic
    Arch Toxicol 84:919-38. 2010
    b>Selenium (Se) is an essential dietary component for animals including humans and is regarded as a protective agent against cancer...
  13. pmc Selenium induces cholinergic motor neuron degeneration in Caenorhabditis elegans
    Annette O Estevez
    Department of Neurology, University of Arizona, Tucson, AZ 85724 5023, USA
    Neurotoxicology 33:1021-32. 2012
    b>Selenium is an essential micronutrient required for cellular antioxidant systems, yet at higher doses it induces oxidative stress...
  14. ncbi Selenium in reproductive health
    Hiten D Mistry
    Maternal and Fetal Research Unit, Division of Women s Health, King s College London, United Kingdom
    Am J Obstet Gynecol 206:21-30. 2012
    b>Selenium is an essential trace element of importance to human biology and health...
  15. ncbi From selenium to selenoproteins: synthesis, identity, and their role in human health
    Laura Vanda Papp
    Queensland Institute of Medical Research, Cancer and Cell Biology Division, Herston, QLD, Australia
    Antioxid Redox Signal 9:775-806. 2007
    The requirement of the trace element selenium for life and its beneficial role in human health has been known for several decades...
  16. ncbi Role of selenium on calcium signaling and oxidative stress-induced molecular pathways in epilepsy
    Mustafa Naziroglu
    Department of Biophysics, Medical Faculty, Suleyman Demirel University, Morfoloji Binasi, Cunur, 32260 Isparta, Turkey
    Neurochem Res 34:2181-91. 2009
    ..Although recent years have seen tremendous progress in the molecular biology and metabolism of selenium, we still know little about the cell type-specific and temporal pattern of selenium and its derivatives in the ..
  17. pmc Transcript analysis of the selenoproteome indicates that dietary selenium requirements of rats based on selenium-regulated selenoprotein mRNA levels are uniformly less than those based on glutathione peroxidase activity
    Kimberly M Barnes
    Department of Nutritional Sciences, University of Wisconsin, Madison, WI 53706, USA
    J Nutr 139:199-206. 2009
    Dietary selenium (Se) requirements in rats have been based largely upon glutathione peroxidase-1 (Gpx1) enzyme activity and Gpx1 mRNA levels can also be used to determine Se requirements...
  18. ncbi Selenium supplementation, baseline plasma selenium status and incidence of prostate cancer: an analysis of the complete treatment period of the Nutritional Prevention of Cancer Trial
    A J Duffield-Lillico
    Arizona Cancer Center, Tucson, USA
    BJU Int 91:608-12. 2003
    ..1996, the end of blinded treatment) of the Nutritional Prevention of Cancer (NPC) Trial, a randomized trial of selenium (200 micro g daily) designed to test the hypothesis that selenium supplementation (SS) could reduce the risk of ..
  19. ncbi Selenium supplementation ameliorates static magnetic field-induced disorders in antioxidant status in rat tissues
    Soumaya Ghodbane
    Laboratoire de Physiologie Integree, Faculte des Sciences de Bizerte, Jarzouna, Tunisia
    Environ Toxicol Pharmacol 31:100-6. 2011
    The aim of this study was to investigate the effect of selenium supplementation on the antioxidant enzymatic system (such as GPx, GR and SOD), GSH and selenium level in liver, kidney, muscle and brain of static magnetic field (SMF) ..
  20. ncbi The glutathione peroxidases
    J R Arthur
    Rowett Research Institute, Aberdeen, Scotland, United Kingdom
    Cell Mol Life Sci 57:1825-35. 2000
    ..These proteins include four selenium-containing glutathione peroxidases that are found in different cell fractions and tissues of the body...
  21. ncbi Selenium nanoparticles as a carrier of 5-fluorouracil to achieve anticancer synergism
    Wen Liu
    Department of Chemistry, Jinan University, Guangzhou 510632, China
    ACS Nano 6:6578-91. 2012
    A simple method for preparing 5-fluorouracil surface-functionalized selenium nanoparticles (5FU-SeNPs) with enhanced anticancer activity has been demonstrated in the present study...
  22. ncbi Focus on mammalian thioredoxin reductases--important selenoproteins with versatile functions
    Elias S J Arner
    Division of Biochemistry, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77 Stockholm, Sweden
    Biochim Biophys Acta 1790:495-526. 2009
    ..Mammalian thioredoxin reductases are selenium-containing flavoprotein oxidoreductases, dependent upon a selenocysteine residue for reduction of the active site ..
  23. ncbi Environmental selenium research: from microscopic processes to global understanding
    Lenny H E Winkel
    Eawag, Swiss Federal Institute of Aquatic Science and Technology, Ueberlandstrasse 133, P O Box 611, 8600 Duebendorf, Switzerland
    Environ Sci Technol 46:571-9. 2012
    b>Selenium is a natural trace element that is of fundamental importance to human health...
  24. pmc Selenium and vitamin E for prostate cancer: post-SELECT (Selenium and Vitamin E Cancer Prevention Trial) status
    Mark C Ledesma
    Department of Dermatology, University of Wisconsin, Madison, Wisconsin, USA
    Mol Med 17:134-43. 2011
    Various formulations of selenium and vitamin E, both essential human dietary components, have been shown to possess a therapeutic and preventive effect against prostate cancer...
  25. ncbi Effect of micronutrient supplementation on mood in nursing home residents
    M A Gosney
    Institute of Health Sciences, University of Reading, Reading, UK ac uk
    Gerontology 54:292-9. 2008
    ..In younger people, deficiencies in selenium, vitamin C and folate are associated with depression...
  26. ncbi Effect of supplementation with selenium on postpartum depression: a randomized double-blind placebo-controlled trial
    Naghmeh Mokhber
    Department of Psychiatry, Ibn Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
    J Matern Fetal Neonatal Med 24:104-8. 2011
    ..The present randomized, double-blind, placebo-controlled trial was conducted to examine the effect of prenatal selenium supplementation on the postpartum depression level in Iranian women.
  27. ncbi Selenoproteins and cancer prevention
    Cindy D Davis
    Nutritional Science Research Group, National Cancer Institute, Rockville, Maryland 20892, USA
    Annu Rev Nutr 32:73-95. 2012
    ..Human variation in the response to selenium likely reflects significant interactions between the type and amounts of selenium consumed with the genome and a ..
  28. ncbi Selenium and selenoproteins in the brain and brain diseases
    Jun Chen
    Department of Cell and Molecular Biology, University of Hawaii at Manoa, Honolulu 96866, USA
    J Neurochem 86:1-12. 2003
    Over the past three decades, selenium has been intensively investigated as an antioxidant trace element...
  29. ncbi Biomethylation of selenium and tellurium: microorganisms and plants
    Thomas G Chasteen
    Department of Chemistry, Sam Houston State University, Huntsville, Texas 77341, USA
    Chem Rev 103:1-25. 2003
  30. pmc Selenium nanoparticles inhibit Staphylococcus aureus growth
    Phong A Tran
    Physics Department, Brown University, Providence, RI, USA
    Int J Nanomedicine 6:1553-8. 2011
    ..While selenium has been used for a wide range of applications including anticancer applications, the effects of selenium ..
  31. ncbi Selenocysteine lyase, a novel enzyme that specifically acts on selenocysteine. Mammalian distribution and purification and properties of pig liver enzyme
    N Esaki
    J Biol Chem 257:4386-91. 1982
    ..L-Cysteine (Ki, 1.0 mM) competes with L-selenocysteine (Km, 0.83 mM) to inhibit the enzyme reaction. The enzyme is the first proven enzyme that specifically acts on selenium compounds.
  32. ncbi Protection against reactive oxygen species by selenoproteins
    Holger Steinbrenner
    Institute for Biochemistry and Molecular Biology I, Heinrich Heine University, Dusseldorf, Germany
    Biochim Biophys Acta 1790:1478-85. 2009
    ..The essential trace element selenium exerts its antioxidant function mainly in the form of selenocysteine residues as an integral constituent of ROS-..
  33. pmc Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration
    Eva K Wirth
    Institute for Experimental Endocrinology, Charite Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    FASEB J 24:844-52. 2010
    Cerebral selenium (Se) deficiency is associated with neurological phenotypes including seizures and ataxia...
  34. ncbi Arsenic and selenium in microbial metabolism
    John F Stolz
    Department of Biological Sciences, Duquesne University, Pittsburgh, Pennsylvania 15282, USA
    Annu Rev Microbiol 60:107-30. 2006
    Arsenic and selenium are readily metabolized by prokaryotes, participating in a full range of metabolic functions including assimilation, methylation, detoxification, and anaerobic respiration...
  35. ncbi In vitro and in vivo studies of methylseleninic acid: evidence that a monomethylated selenium metabolite is critical for cancer chemoprevention
    C Ip
    Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Cancer Res 60:2882-6. 2000
    Previous research suggested that the beta-lyase-mediated production of a monomethylated selenium metabolite from Se-methylselenocysteine is a key step in cancer chemoprevention by this agent...
  36. ncbi Effects of long-term selenium supplementation on the incidence of type 2 diabetes: a randomized trial
    Saverio Stranges
    State University of New York at Buffalo and Cancer Prevention and Population Sciences, Roswell Park Cancer Institute, Buffalo, New York, USA
    Ann Intern Med 147:217-23. 2007
    Findings from animal models suggest that selenium supplementation improves glucose metabolism.
  37. ncbi Both selenoproteins and low molecular weight selenocompounds reduce colon cancer risk in mice with genetically impaired selenoprotein expression
    Robert Irons
    Nutritional Science Research Group, National Cancer Institute, Rockville, MD 20852, USA
    J Nutr 136:1311-7. 2006
    b>Selenium has cancer protective effects in a variety of experimental systems. Currently, it is not known whether selenoproteins or low molecular weight selenocompounds are responsible for this activity...
  38. ncbi Trace elements and cancer risk: a review of the epidemiologic evidence
    Stephanie A Navarro Silvera
    Department of Epidemiology and Population Health, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Room 1301a, New York, NY 10461, USA
    Cancer Causes Control 18:7-27. 2007
    ..Trace elements, such as selenium, zinc, arsenic, cadmium, and nickel, are found naturally in the environment, and human exposure derives from a ..
  39. ncbi Evaluating selenium poisoning
    Kern L Nuttall
    Laboratory Medicine, Bellingham, WA 98229, USA
    Ann Clin Lab Sci 36:409-20. 2006
    b>Selenium poisoning in humans is reviewed from the perspective of the clinical laboratory...
  40. ncbi Plasma selenium over time and cognitive decline in the elderly
    Tasnime N Akbaraly
    Inserm E361 Université Montpellier1, Montpellier, France
    Epidemiology 18:52-8. 2007
    Because brain oxidative stress is a cause of cognitive impairment, selenium, which is an antioxidant, may protect against cognitive decline...
  41. ncbi Positive surface charge enhances selective cellular uptake and anticancer efficacy of selenium nanoparticles
    Bo Yu
    Department of Chemistry, Jinan University, Guangzhou 510632, China
    Inorg Chem 51:8956-63. 2012
    Surface charge plays a key role in cellular uptake and biological actions of nanomaterials. Selenium nanoparticles (SeNPs) are novel Se species with potent anticancer activity and low toxicity...
  42. pmc Determinants of selenium status in healthy adults
    Gerald F Combs
    Grand Forks Human Nutrition Research Center, USDA ARS, Grand Forks, ND, USA
    Nutr J 10:75. 2011
    b>Selenium (Se) status in non-deficient subjects is typically assessed by the Se contents of plasma/serum...
  43. pmc Selenium and lung cancer: a systematic review and meta analysis
    Heidi Fritz
    Department of Research and Epidemiology, The Canadian College of Naturopathic Medicine, Toronto, Ontario, Canada
    PLoS ONE 6:e26259. 2011
    b>Selenium is a natural health product widely used in the treatment and prevention of lung cancers, but large chemoprevention trials have yielded conflicting results...
  44. ncbi Selenium and selenoproteins in mammals: extraordinary, essential, enigmatic
    L Schomburg
    Institut für Experimentelle Endokrinologie, Charite Universitatsmedizin Berlin, Schumannstrasse 20 21, 10117, Berlin, Germany
    Cell Mol Life Sci 61:1988-95. 2004
    b>Selenium (Se), once known only for its potential toxicity, is now well established as an essential trace element for mammals. Insufficient Se intake predisposes to and manifests in a variety of diseases...
  45. ncbi Dietary selenium and major depression: a nested case-control study
    Julie A Pasco
    School of Medicine, Deakin University, Geelong, Victoria 3220, Australia
    Complement Ther Med 20:119-23. 2012
    ..biology are established in depression; however, there are no prospective epidemiological data on redox-active selenium in depression...
  46. pmc The human selenoproteome: recent insights into functions and regulation
    M A Reeves
    Department of Cell and Molecular Biology, John A Burns School of Medicine, University of Hawaii, 651 Ilalo Street, Honolulu, HI 96813, USA
    Cell Mol Life Sci 66:2457-78. 2009
    b>Selenium (Se) is a nutritional trace mineral essential for various aspects of human health that exerts its effects mainly through its incorporation into selenoproteins as the amino acid, selenocysteine...
  47. ncbi Association between GPx1 Pro198Leu polymorphism, GPx1 activity and plasma selenium concentration in humans
    E Jablonska
    Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lodz, Poland
    Eur J Nutr 48:383-6. 2009
    ..Its activity depends on the concentration of selenium (Se) which is present in the active centre of the enzyme...
  48. pmc How selenium has altered our understanding of the genetic code
    Dolph L Hatfield
    Molecular Biology of Selenium Section, Basic Research Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Mol Cell Biol 22:3565-76. 2002
  49. ncbi Methods of assessment of selenium status in humans: a systematic review
    Kate Ashton
    School of Medicine, Health Policy and Practice, The University of East Anglia, Norwich, United Kingdom
    Am J Clin Nutr 89:2025S-2039S. 2009
    To understand the effect of selenium intake on health, it is important to identify sensitive and population-specific biomarkers of selenium status.
  50. ncbi Differential responses to selenomethionine supplementation by sex and genotype in healthy adults
    Gerald F Combs
    Grand Forks Human Nutrition Research Center, USDA ARS, 2420 2nd Avenue North, Stop 9034, Grand Forks, ND 58202 9034, USA
    Br J Nutr 107:1514-25. 2012
    ..In a cohort of relatively high Se status, the Se intake (as SeMet) required to support plasma Se concentration at a target level (Se(pl-target)) is: Se(in) = [(Se(pl - target) - Se(pl))/(18.2ng d kg⁰.⁷⁵/ml per mu g)] ...
  51. pmc Selenium effectively inhibits 1,2-dihydroxynaphthalene-induced apoptosis in human lens epithelial cells through activation of PI3-K/Akt pathway
    Xiangjia Zhu
    Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, P R China
    Mol Vis 17:2019-27. 2011
    ..whether activation of the phosphatidylinositol 3-kinase (PI3-K)/protein kinase B (Akt) pathway was necessary for selenium in protecting human lens epithelial cells (hLECs) from 1,2-dihydroxynaphthalene (1,2-DHN)-induced apoptosis...
  52. pmc Both maximal expression of selenoproteins and selenoprotein deficiency can promote development of type 2 diabetes-like phenotype in mice
    Vyacheslav M Labunskyy
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, 77 Ave Louis Pasteur, Boston, MA 02115, USA
    Antioxid Redox Signal 14:2327-36. 2011
    b>Selenium (Se) is an essential trace element in mammals that has been shown to exert its function through selenoproteins...
  53. ncbi Selenium metabolism, selenoproteins and mechanisms of cancer prevention: complexities with thioredoxin reductase
    H E Ganther
    Department of Nutritional Sciences, University of Wisconsin, 1415 Linden Drive, Madison, WI 53706, USA
    Carcinogenesis 20:1657-66. 1999
    ..b>Selenium may facilitate reactions of protein cysteine residues by the transient formation of more reactive S-Se ..
  54. pmc Selenium toxicity but not deficient or super-nutritional selenium status vastly alters the transcriptome in rodents
    Anna M Raines
    Department of Nutritional Sciences, University of Wisconsin, 1415 Linden Drive, Madison, WI 53706, USA
    BMC Genomics 12:26. 2011
    ..levels for several selenoproteins, such as glutathione peroxidase-1 (Gpx1), are down-regulated dramatically by selenium (Se) deficiency...
  55. ncbi Selenium
    D G Barceloux
    J Toxicol Clin Toxicol 37:145-72. 1999
    The 4 natural oxidation states of selenium are elemental selenium (0), selenide (-2), selenite (+4), and selenate (+6)...
  56. ncbi Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds
    Cristina W Nogueira
    Laboratorio de Sintese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciencias Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil
    Arch Toxicol 85:1313-59. 2011
    The advance in the area of synthesis and reactivity of organoselenium, as well as the discovery that selenium was the cause of severe intoxication episodes of livestock in the 1930s and the subsequent determination that selenium was an ..
  57. ncbi Reduction of selenite to elemental red selenium by Rhizobium sp. strain B1
    William J Hunter
    USDA ARS, Fort Collins, CO 80526 8119, USA
    Curr Microbiol 55:344-9. 2007
    A bacterium that reduces the soluble and toxic selenite anion to insoluble elemental red selenium (Se(0)) was isolated from a laboratory bioreactor...
  58. pmc The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation
    Jun Panee
    Department of Cell and Molecular Biology, John A Burns Medical School, University of Hawaii, Honolulu, HI 96813, USA
    Int J Biol Sci 3:335-41. 2007
    ..of gene expression of antioxidant enzymes and phase II enzymes, also evaluated potential protective effect of selenium (Se) supplementation to the cells under this oxidative stress...
  59. ncbi Neurological dysfunction occurs in mice with targeted deletion of the selenoprotein P gene
    Kristina E Hill
    Division of Gastroenterology and Clinical Nutrition Research Unit, Vanderbilt University School of Medicine, Nashville, TN 37232, USA
    J Nutr 134:157-61. 2004
    Brain function and selenium concentration are well maintained in rodents under conditions of selenium deficiency...
  60. ncbi Elemental selenium at nano size possesses lower toxicity without compromising the fundamental effect on selenoenzymes: comparison with selenomethionine in mice
    Huali Wang
    University of Science and Technology of China, Hefei 230052, People s Republic of China
    Free Radic Biol Med 42:1524-33. 2007
    Glutathione peroxidase and thioredoxin reductase are major selenoenzymes through which selenium exerts powerful antioxidant effects. Selenium also elicits pro-oxidant effects at toxic levels...
  61. pmc Selenoprotein gene expression in thyroid and pituitary of young pigs is not affected by dietary selenium deficiency or excess
    Ji Chang Zhou
    International Center of Future Agriculture for Human Health, Sichuan Agricultural University, Chengdu, Sichuan 611134, China
    J Nutr 139:1061-6. 2009
    ..2 experiments: 1) we cloned 5 novel porcine selenoprotein genes; and 2) we compared the effects of dietary selenium (Se) on mRNA levels of 12 selenoproteins, activities of 4 antioxidant enzymes, and Se concentrations in testis, ..
  62. pmc Reduced reliance on the trace element selenium during evolution of mammals
    Alexey V Lobanov
    Department of Biochemistry, University of Nebraska, Lincoln, NE 68588, USA
    Genome Biol 9:R62. 2008
    b>Selenium (Se) is an essential trace element that occurs in proteins in the form of selenocysteine (Sec)...
  63. ncbi Selenium nanoparticles fabricated in Undaria pinnatifida polysaccharide solutions induce mitochondria-mediated apoptosis in A375 human melanoma cells
    Tianfeng Chen
    Department of Biology, The Chinese University of Hong Kong, Hong Kong SAR, China
    Colloids Surf B Biointerfaces 67:26-31. 2008
    b>Selenium nanoparticle (Nano-Se) is a novel Se species with novel biological activities and low toxicity...
  64. ncbi Epithelium-specific glutathione peroxidase, Gpx2, is involved in the prevention of intestinal inflammation in selenium-deficient mice
    R Steven Esworthy
    Department of Medical Oncology and Therapeutics Research, City of Hope Comprehensive Cancer Center, Duarte, CA 91010 3000, USA
    J Nutr 135:740-5. 2005
    Mice deficient in 2 intracellular selenium (Se)-dependent glutathione peroxidases (Gpx1 and Gpx2), by genetically disrupting both alleles of the Gpx1 and Gpx2 genes (Gpx1(-/-)Gpx2(-/-)), develop ileocolitis around weaning...
  65. ncbi Antioxidant and anticancer properties and mechanisms of inorganic selenium, oxo-sulfur, and oxo-selenium compounds
    Ria R Ramoutar
    Chemistry Department, Clemson University, Clemson, SC 29634, USA
    Cell Biochem Biophys 58:1-23. 2010
    Inorganic selenium and oxo-sulfur compounds are widely available in dietary supplements and have been extensively studied for their antioxidant and anticancer properties...
  66. ncbi Comparison of short-term toxicity between Nano-Se and selenite in mice
    Jinsong Zhang
    University of Science and Technology of China, Hefei, 230052 P R China
    Life Sci 76:1099-109. 2005
    We previously reported that, as compared with selenite, nano red elemental selenium (Nano-Se) had lower acute toxicity in mice and similar bioavailability in terms of up-regulating seleno-enzymes...
  67. ncbi Reduction of selenite to red elemental selenium by moderately halotolerant Bacillus megaterium strains isolated from Bhitarkanika mangrove soil and characterization of reduced product
    Rashmi Ranjan Mishra
    Department of Biotechnology, North Orissa University, Takatapur, Baripada 757 003, Orissa, India
    Chemosphere 84:1231-7. 2011
    ..SEM with energy dispersive X-ray and TEM analyses revealed the formation of nano size spherical selenium particles in and around the bacterial cells which were also supported by the confocal micrograph study...
  68. pmc Glutathione peroxidase-2 and selenium decreased inflammation and tumors in a mouse model of inflammation-associated carcinogenesis whereas sulforaphane effects differed with selenium supply
    Susanne Krehl
    Department of Biochemistry of Micronutrients, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Carcinogenesis 33:620-8. 2012
    Chronic inflammation and selenium deficiency are considered as risk factors for colon cancer. The protective effect of selenium might be mediated by specific selenoproteins, such as glutathione peroxidases (GPx)...
  69. ncbi Level of trace elements (copper, zinc, magnesium and selenium) and toxic elements (lead and mercury) in the hair and nail of children with autism
    Malarveni Damodaran Lakshmi Priya
    Department of Biochemistry, Bharathi Women s College, Chennai, 600 108 Tamil Nadu, India
    Biol Trace Elem Res 142:148-58. 2011
    ..of the present study was to assess the levels of trace elements like copper (Cu), zinc (Zn), magnesium (Mg), and selenium (Se) and toxic elements like mercury (Hg), and lead (Pb) in the hair and nail samples of autistic children and to ..
  70. ncbi Methylselenol, a selenium metabolite, induces cell cycle arrest in G1 phase and apoptosis via the extracellular-regulated kinase 1/2 pathway and other cancer signaling genes
    Huawei Zeng
    USDA, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, ND 58202 9034, USA
    J Nutr 139:1613-8. 2009
    Methylselenol has been hypothesized to be a critical selenium (Se) metabolite for anticancer activity in vivo, and our previous study demonstrated that submicromolar methylselenol generated by incubating methionase with seleno-l-..
  71. ncbi Selenium or no selenium--that is the question in tumor patients: a new controversy
    Ralph Muecke
    Lippe Hospital, Lemgo, Germany
    Integr Cancer Ther 9:136-41. 2010
    The essential trace element selenium, which is a crucial cofactor in the most important endogenous antioxidative systems of the human body, is attracting more attention from both laypersons and expert groups...
  72. pmc Selenium status highly regulates selenoprotein mRNA levels for only a subset of the selenoproteins in the selenoproteome
    Roger A Sunde
    Department of Nutritional Sciences, University of Wisconsin Madison, Madison, WI 53706, USA
    Biosci Rep 29:329-38. 2009
    Gpx (glutathione peroxidase)-1 enzyme activity and mRNA levels decrease dramatically in Se (selenium) deficiency, whereas other selenoproteins are less affected by Se deficiency...
  73. ncbi Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study
    Mohammad Reza Safarinejad
    Urology and Nephrology Research Center, Shahid Beheshti University, MC, Tehran, Islamic Republic of Iran
    J Urol 181:741-51. 2009
    We explored the efficacy of selenium and/or or N-acetyl-cysteine for improving semen parameters in infertile men, and the associations among semen quality and the concentrations of selenium and N-acetyl-cysteine in seminal plasma.
  74. ncbi Selenium in human and animal nutrition: resolved and unresolved issues. A partly historical treatise in commemoration of the fiftieth anniversary of the discovery of the biological essentiality of selenium, dedicated to the memory of Klaus Schwarz (1914-1
    Gerhard N Schrauzer
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA
    Crit Rev Biotechnol 29:2-9. 2009
    b>Selenium (Se) is an essential trace element unevenly distributed on the Earth's crust with low selenium regions predominating...
  75. ncbi Selenium, selenoproteins and human health: a review
    K M Brown
    University of Aberdeen, Scotland
    Public Health Nutr 4:593-9. 2001
    b>Selenium is of fundamental importance to human health. It is an essential component of several major metabolic pathways, including thyroid hormone metabolism, antioxidant defence systems, and immune function...
  76. ncbi Serum selenium and diabetes in U.S. adults
    Joachim Bleys
    Department of Epidemiology, The Welch Center for Prevention, Epidemiology, and Clinical Research, Baltimore, Maryland 21205, USA
    Diabetes Care 30:829-34. 2007
    The purpose of this study was to examine the relationship between serum selenium levels and the prevalence of diabetes among U.S. adults.
  77. ncbi Genetic polymorphisms in the human selenoprotein P gene determine the response of selenoprotein markers to selenium supplementation in a gender-specific manner (the SELGEN study)
    Catherine Méplan
    Institute for Cell and Molecular Biosciences and Human Nutrition Research Centre, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH UK
    FASEB J 21:3063-74. 2007
    b>Selenium (Se), a micronutrient essential for human health, is incorporated into at least 25 selenoproteins including selenoprotein P (SePP), which transports Se within the body...
  78. pmc Establishing optimal selenium status: results of a randomized, double-blind, placebo-controlled trial
    Rachel Hurst
    School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK
    Am J Clin Nutr 91:923-31. 2010
    Dietary recommendations for selenium differ between countries, mainly because of uncertainties over the definition of optimal selenium status.
  79. ncbi Mammalian selenium-containing proteins
    D Behne
    Department Molecular Trace Element Research in the Life Sciences, Hahn Meitner Institut Berlin, Glienicker Strasse 100, D 14109 Berlin, Germany
    Annu Rev Nutr 21:453-73. 2001
    Mammalian selenium-containing proteins can be divided into three groups: proteins containing nonspecifically incorporated selenium, specific selenium-binding proteins, and specific selenocysteine-containing selenoproteins...
  80. ncbi Selenium sensitizes MCF-7 breast cancer cells to doxorubicin-induced apoptosis through modulation of phospho-Akt and its downstream substrates
    Song Li
    Department of Cancer Chemoprevention, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA
    Mol Cancer Ther 6:1031-8. 2007
    ..By combining doxorubicin with selenium, we were successful in producing a brisk enhancement of apoptosis...
  81. ncbi Selenium in global food systems
    G F Combs
    Department of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
    Br J Nutr 85:517-47. 2001
    ..Accordingly, low Se status is likely to contribute to morbidity and mortality due to infectious as well as chronic diseases, and increasing Se intakes in all parts of the world can be expected to reduce cancer rates...
  82. ncbi Baseline characteristics and the effect of selenium supplementation on cancer incidence in a randomized clinical trial: a summary report of the Nutritional Prevention of Cancer Trial
    Anna J Duffield-Lillico
    Arizona Cancer Center, Tucson, Arizona 85724 5024, USA
    Cancer Epidemiol Biomarkers Prev 11:630-9. 2002
    The Nutritional Prevention of Cancer Trial was a randomized, clinical trial designed to evaluate the efficacy of selenium as selenized yeast (200 microg daily) in preventing the recurrence of nonmelanoma skin cancer among 1312 residents ..
  83. ncbi Selenium as an anticancer nutrient: roles in cell proliferation and tumor cell invasion
    Huawei Zeng
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, P O Box 9034, Grand Forks, ND 58202 9034, USA
    J Nutr Biochem 19:1-7. 2008
    b>Selenium is an essential dietary component for animals including humans, and there is increasing evidence for the efficacy of certain forms of selenium as cancer-chemopreventive compounds...
  84. ncbi Free radical scavenging efficiency of Nano-Se in vitro
    Bo Huang
    Center for Molecular Biology, Institute of Biophysics, Chinese Academy of Sciences, Beijing, P R China
    Free Radic Biol Med 35:805-13. 2003
    ..Although in this study we regarded Nano-Se as a whole without considering interactions between BSA and the red selenium nano-particles, there is the possibility that the apparent free radical scavenging effects may be partially ..
  85. ncbi Effectiveness of selenium supplements in a low-selenium area of China
    Yiming Xia
    Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing, China
    Am J Clin Nutr 81:829-34. 2005
    b>Selenium is an essential micronutrient with a recommended dietary allowance for adults of 55 mug/d. It functions as an essential constituent of selenoproteins...
  86. ncbi Assessment of requirements for selenium and adequacy of selenium status: a review
    C D Thomson
    Department of Human Nutrition, University of Otago, Dunedin, New Zealand
    Eur J Clin Nutr 58:391-402. 2004
    The intent of this review is to evaluate the scientific evidence for the assessment of adequacy of selenium status and of the requirements for selenium...
  87. ncbi Selenium and prostate cancer: systematic review and meta-analysis
    Rachel Hurst
    Department of Nutrition, Norwich Medical School, University of East Anglia, Norwich, Norfolk, United Kingdom
    Am J Clin Nutr 96:111-22. 2012
    Prostate cancer is a growing public health problem. Several human studies have shown a potentially protective effect of selenium, but the conclusions from published reports are inconsistent.
  88. pmc Selenoprotein P-expression, functions, and roles in mammals
    Raymond F Burk
    Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, 1030C Medical Research Building IV, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 0252, USA
    Biochim Biophys Acta 1790:1441-7. 2009
    ..Hepatic synthesis of Sepp1 affects whole-body selenium content and the liver is the source of most plasma Sepp1...
  89. ncbi The use of high-selenium yeast to raise selenium status: how does it measure up?
    Margaret P Rayman
    Centre for Nutrition and Food Safety, School of Biomedical and Molecular Sciences, University of Surrey, UK
    Br J Nutr 92:557-73. 2004
    b>Selenium-enriched yeast (Se-yeast) is a common form of Se used to supplement the dietary intake of this important trace mineral...
  90. ncbi Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations
    Roland Gärtner
    Department of Endocrinology, Medizinische Klinik Innenstadt, University of Munich, D 80336 Munich, Germany
    J Clin Endocrinol Metab 87:1687-91. 2002
    In areas with severe selenium deficiency there is a higher incidence of thyroiditis due to a decreased activity of selenium-dependent glutathione peroxidase activity within thyroid cells...
  91. ncbi Food-chain selenium and human health: spotlight on speciation
    Margaret P Rayman
    Nutritional Sciences Division, Faculty of Health and Medical Sciences, University of Surrey, Guildford, Surrey GU2 7XH, UK
    Br J Nutr 100:238-53. 2008
    ..There remain considerable gaps in our knowledge of the forms of Se that naturally occur in foods. Without adequate knowledge of Se speciation, false conclusions may be drawn when assessing Se requirements for optimal health...
  92. ncbi Selenium deficiency and viral infection
    Melinda A Beck
    Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    J Nutr 133:1463S-7S. 2003
    ..disease likely has a dual etiology that involves both a nutritional deficiency of the essential trace mineral selenium (Se) as well as an infection with an enterovirus provided the impetus for additional studies of relationships ..
  93. ncbi The anti-inflammatory effects of selenium are mediated through 15-deoxy-Delta12,14-prostaglandin J2 in macrophages
    Hema Vunta
    Department of Veterinary and Biomedical Sciences, Centers for Molecular Toxicology and Carcinogenesis, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 282:17964-73. 2007
    b>Selenium is an essential micronutrient that suppresses the redox-sensitive transcription factor NF-kappaB-dependent pro-inflammatory gene expression...
  94. ncbi Cruciferous vegetables: cancer protective mechanisms of glucosinolate hydrolysis products and selenium
    Anna Sigrid Keck
    United States Department of Agriculture, Agricultural Research Service, Grand Forks Human Nutrition Research Center, Grand Forks, North Dakota 58202 9034, USA
    Integr Cancer Ther 3:5-12. 2004
    ..This review describes the anticarcinogenic bioactivities of glucosinolate hydrolysis products, the mineral selenium derived from crucifers, and the mechanisms by which they protect against cancer...
  95. ncbi Selenoprotein P: an extracellular protein with unique physical characteristics and a role in selenium homeostasis
    Raymond F Burk
    Division of Gastroenterology, Department of Medicine and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA
    Annu Rev Nutr 25:215-35. 2005
    ..It has two domains with respect to selenium content. The N-terminal domain of the rat protein contains one selenocysteine residue in a UxxC redox motif...
  96. ncbi Selenium, the thyroid, and the endocrine system
    J Kohrle
    Institut für Experimentelle Endokrinologie, Charite, Humboldt Universitat zu Berlin, Schumannstrasse 20 21, D 10098 Berlin, Germany
    Endocr Rev 26:944-84. 2005
    ..of new selenocysteine-containing proteins has revealed relationships between the two trace elements selenium (Se) and iodine and the hormone network...
  97. ncbi Dietary selenium's protective effects against methylmercury toxicity
    Nicholas V C Ralston
    Energy and Environmental Research Center, University of North Dakota, 15 North 23rd Street, Grand Forks, ND 58202, USA
    Toxicology 278:112-23. 2010
    Dietary selenium (Se) status is inversely related to vulnerability to methylmercury (MeHg) toxicity...
  98. ncbi Selenium and brain function: a poorly recognized liaison
    Ulrich Schweizer
    Neurobiology of Selenium, Neuroscience Research Center, Charite, University Medical School, Berlin, Germany
    Brain Res Brain Res Rev 45:164-78. 2004
    Molecular biology has recently contributed significantly to the recognition of selenium (Se)2 and Se-dependent enzymes as modulators of brain function...
  99. ncbi Hierarchical regulation of selenoprotein expression and sex-specific effects of selenium
    Lutz Schomburg
    Institute for Experimental Endocrinology, Südring 10, CVK, Charite Universitatsmedizin Berlin, 13353 Berlin, Germany
    Biochim Biophys Acta 1790:1453-62. 2009
    ..g. in cancer, inflammation or neurodegeneration. Likewise, important health issues related to the selenium status show unexpected sexual dimorphisms...
  100. ncbi Selenium and the selenoprotein thioredoxin reductase in the prevention, treatment and diagnostics of cancer
    Markus Selenius
    Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, Stockholm, Sweden
    Antioxid Redox Signal 12:867-80. 2010
    b>Selenium is an essential element that is specifically incorporated as selenocystein into selenoproteins. It is a potent modulator of eukaryotic cell growth with strictly concentration-dependant effects...
  101. ncbi Selenoproteins and human health: insights from epidemiological data
    Margaret P Rayman
    Division of Nutritional Sciences, Faculty of Health and Medical Sciences, University of Surrey, Guildford, GU2 7XH, UK
    Biochim Biophys Acta 1790:1533-40. 2009
    Knowledge of the plasma selenium levels associated with optimised concentration or activity of specific selenoproteins can provide considerable insights from epidemiological data on the possible involvement of those selenoproteins in ..

Research Grants75

  1. FOLLOW UP OF THE ALPHA-TOCOPHEROL, BETA-CAROTENE CANCER PREVENTION (ATBC) STUDY
    Jarmo Virtamo; Fiscal Year: 2010
    ..We have pursued and completed investigations of vitamin E and selenium status;carotenoids and other antioxidants;one-carbon metabolism;energy balance, insulin, and growth factors;sex ..
  2. METABOLISM, MICRONUTRIENTS, AND ANTIRETROVIRAL THERAPY OUTCOMES IN ZAMBIA
    DOUGLAS CORBETT HEIMBURGER; Fiscal Year: 2010
    ..and creatinine), selected micronutrients (ferritin for iron status, folic acid, vitamins A, B12, and E, and selenium), and inflammatory markers (C-reactive protein and 1-1-acid glycoprotein) before and during ART...
  3. Biomarkers to Assess Selenium Chemoprevention for NSCLC
    Steven A Belinsky; Fiscal Year: 2012
    ..In 1996, Dr. Larry Clark reported that the rate of expected lung cancer in a population taking selenium decreased by approximately 50%...
  4. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
  5. The influence of selenium on biomarkers of prostate cancer risk
    KARAM E EL-BAYOUMY; Fiscal Year: 2012
    ..Older people develop trace element deficiencies (e.g., selenium);recently, we showed that older rats also develop selenium deficiency...
  6. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..5 years of age. At that time, Mn and Pb will be measured in blood;Mn, As, and selenium (Se) in hair;and As and Se in nails...
  7. Prostate cancer prevention by selenium supplementation
    Rayudu Gopalakrishna; Fiscal Year: 2012
    b>Selenium prevents cancer in some cases and fails to prevent it in other cases. Furthermore, in some cases, it may cause toxicity to the host...
  8. Alcohol &Antiretrovirals in HIV Infection, Oxidative Stress and Liver Disease
    Marianna K Baum; Fiscal Year: 2012
    ..Plasma antioxidants (glutathione, vitamins A and E, 1 and 2-carotenes, zinc and selenium) will also be determined...
  9. Timing of Exposure to Selenium and Isoflavones and Prostate Cancer Prevention
    EDWIN DOUGLAS LEPHART; Fiscal Year: 2010
    ..Recent data demonstrate that high selenium (Se) intake or status and high intake of phytoestrogens (isoflavones) each provide a protective effect against ..
  10. Characterizing Mitochondrial DNA Susceptibility to Breast, Colorectal, and Prosta
    Iona Cheng; Fiscal Year: 2012
    ..related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C, vitamin E, iron, lycopene and selenium) and susceptibility loci for breast, colorectal and/or prostate cancer identified by genome-wide association ..
  11. Selenoprotein K modulates calcium-dependent signaling in immune cells
    PETER R HOFFMAN; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium (Se) is an essential micronutrient important for many aspects of human health, including optimal immune responses...
  12. Methylmercury exposure, mercury metabolism genotypes, and risk of adult glioma
    Kathleen M Egan; Fiscal Year: 2013
    ..antioxidant effects of glutathione and selenoproteins, enzymes which mediate most of the antioxidant functions of selenium. The project will be based on a multicenter NCI-funded (R01 CA116174) case-control study exploring genetic and ..
  13. Pilot-Scale Heterocyclic and Carbocyclic Libraries for High Throughout Screening
    RICHARD LAROCK; Fiscal Year: 2009
    ..2) The cyclization of readily available, functionally-substituted alkynes by halogen, sulfur, selenium and organopalladium electrophiles will be utilized to prepare libraries of medicinally interesting indoles, ..
  14. Preventive of Bile Acid-Induced Colonic Oxidative DNA Damage
    Claire Margaret Payne; Fiscal Year: 2010
    ..agents that interfere with the deleterious effects of DOC and include parthenolide, an NF-=B inhibitor, organic selenium compounds, chlorogenic acid and novel antioxidants that target mitochondria (e.g. MitoQ-ubiquinol)...
  15. UNC-CH Nutrition Obesity Research Center
    Steven H Zeisel; Fiscal Year: 2013
    ..metabolism, the effects of obesity on immune responses to viruses, and the mechanisms whereby antioxidants and selenium modulate viral mutation and pathogenesis...
  16. Selenium, other risk factors and cognitive decline in rural elderly Chinese
    Sujuan Gao; Fiscal Year: 2013
    ..b>Selenium is a trace element that is considered a defensive agent against free radicals through the maintenance of better ..
  17. Antioxidative role of GPX1 in transgenic mice.
    XINGEN LEI; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Cellular glutathione peroxidase-1 (GPX1) is the first identified selenium-dependent protein and a major intracellular antioxidant enzyme in mammals...
  18. The Biological and Chemical Function of Selenium in Enzymes
    Robert J Hondal; Fiscal Year: 2013
    ..given reasons for the use of Sec is that it is a type of "super-Cys" residue that can "speed reactions" due to selenium's superior chemical reactivity relative to sulfur...
  19. Prostate cancer prevention by tocopherols
    Ah Ng Tony Kong; Fiscal Year: 2013
    ..Significance of the Proposed Research: Selenium and Vitamin E Cancer Prevention Trial (SELECT), a clinical trial to determine if one or both of these cancer ..
  20. ISU Vet-LIRN Collaborative Validation of Testing Methods on Animal Diagnostic Spe
    WILSON KIIZA RUMBEIHA; Fiscal Year: 2013
    ..unique expertise in including aflatoxins, Ractopamine, ionophores, ergot alkaloids, bromethalin, Cholecalciferol, selenium, coumesterol, zearalenone and cyanotoxins...
  21. Mechanism of selenoprotein synthesis
    Marla Berry; Fiscal Year: 2009
    Project Summary/Abstract Selenium is an essential trace element long known for its antioxidant properties, most or all of which are attributable to selenoproteins...
  22. Atlanta Regional Community Clinical Oncology Program (ARCCOP)
    Thomas E Seay; Fiscal Year: 2012
    ..The ARCCOP is a clinical site for the Study of Tamoxifen and Raloxefene (STAR) and the Selenium and Vitamin E Cancer Prevention Trial (SELECT) for breast and prostate cancer prevention respectively...
  23. SOUTHWEST ONCOLOGY GROUP
    Gary E Goodman; Fiscal Year: 2013
    ..The Selenium and Vitamin E Trial has accrued 960 patients, the SELECT Ancillary Study accrued 191 patients, and the UCOP ..
  24. Mitochondrial Genetic Susceptibility to Breast and Prostate Cancers
    Iona Cheng; Fiscal Year: 2013
    ..related to mitochondrial activity (smoking, BMI, fat, carotenoids, vitamin C, vitamin E, iron, lycopene and selenium) and susceptibility loci for breast and prostate cancer identified by genome-wide association studies...
  25. Selenium Colorectal Cancer Chemoprevention Trials
    PATRICIA ANN THOMPSON; Fiscal Year: 2013
    ..When given as a supplement, selenium (Se), a trace dietary mineral that is incorporated into specialized selenoproteins was previously shown to ..
  26. Studies of Transfer RNA
    Dieter Soll; Fiscal Year: 2013
    ..II) Selenium, in the form of selenocysteine (Sec), is an essential trace element for human health, and selenoprotein mutations ..
  27. Redox Mechanisms of Chemoprevention in Lung by Selenium Supplementation
    ROBYN POERSCHKE; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Cancer prevention by selenium (Se) has been shown to be compound and model dependent, but the mechanisms are not well understood...
  28. Colorectal Neoplasia in SELECT Participants
    M PETER LANCE; Fiscal Year: 2011
    ..Considerable indirect evidence supports a chemopreventive role for selenium against CRC...
  29. Translational Recoding of UGA as Selenocysteine in Selenoprotein Synthesis
    Donna M Driscoll; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium is an essential micronutrient that exerts many important health benefits...
  30. Methionine sulfoxide reduction, selenium and aging
    Vadim N Gladyshev; Fiscal Year: 2012
    ..MsrB, MsrB1, is a selenocysteine-containing protein, whose expression and activity can be regulated by dietary selenium. Little is known about Met oxidation and repair in vivo and about identities of molecular targets of methionine ..
  31. Factors Modifying the Toxicity of Methylmercury in a Fish-Eating Population
    Philip W Davidson; Fiscal Year: 2013
    ..that the apparent effect modification seen in their earlier study may have been due to anti- oxidants (selenium and vitamin E) in the maternal diet, as well as the anti-inflammatory effects of n-3 PUFA from fish consumption...
  32. Selenium as an adjuvant to imatinib therapy
    Alan Diamond; Fiscal Year: 2010
    ..Recently, it has been shown that imatinab also inhibits the activating phosphorylation of the selenium-dependent enzyme glutathione peroxidase (GPx-1)...
  33. Dietary Supplement Selenium and HIF-1alpha Regulation in Cancer
    Sreenivasulu Chintala; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): The chemopreventive effects of the essential dietary trace element Selenium (Se) is known to impact cancer incidence and mortality, however its antiangiogenic role makes it a possible novel and ideal ..
  34. Targeting Leukemia Stem Cells with Dietary Selenium
    KUMBLE SANDEEP PRABHU; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium (Se) is incorporated into selenoproteins as selenocysteine to impart anti-cancer, antioxidant, and anti-inflammatory functions...
  35. The mechanism of selenium incorporation into selenocysteine in humans.
    Miljan Simonovic; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium, the only genetically encoded dietary micronutrient, is essential for human health and survival...
  36. Chemoprevention of arsenic-induced skin cancer
    Habibul Ahsan; Fiscal Year: 2013
    ..To identify an effective preventive approach for this increased risk we established the Bangladesh vitamin E and selenium Trial (BEST)-a 2W2 factorial randomized chemoprevention trial (RCT) for evaluating whether long- term vitamin E ..
  37. Colloidal Quantum Dot/Well Near-Infrared NanoLabels
    Hua Mao; Fiscal Year: 2010
    ..regulation environment in advanced countries, human body can tolerate a small amount of indium, arsenic and selenium. During the Phase I program, this SBIR team finally overcame the main scientific hurdles for realizing such a ..
  38. PDEF and survivin: cancer prognosis, initiation, progression and metastasis
    Fengzhi Li; Fiscal Year: 2010
    ..Accordingly, many natural dietary components, including resveratrol, silibinin, sulindac, retinoid, selenium and vitamin D compounds that have cancer-preventive and therapeutic effects, downregulate survivin expression...
  39. GPx-3 and Peroxide Flux in the Endothelial Cell
    Joseph Loscalzo; Fiscal Year: 2013
    ..First, we will examine the effect of hypoxia on GPx-3 expression, selenium uptake, and the selenoprotein synthesis hierarchy (in renal tubular cells, the primary source of plasma GPx-3 in ..
  40. Peroxiredoxin 6 as an Anti-oxidant Enzyme
    Aron B Fisher; Fiscal Year: 2013
    ..This recently described protein called peroxiredoxin 6 (Prdx6 or 1-cys Peroxiredoxin) represents the only non-selenium glutathione peroxidase of relatively high specific activity...
  41. Selenium and Selenoprotein P Modify Colorectal Tumorigenesis
    Caitlyn W Barrett; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium is a necessary trace element that is incorporated as selenocysteine into selenoproteins via the co-translational modification of transfer RNA-bound serine...
  42. ISC-4 as a Novel Lung Cancer Chemopreventive Agent
    Arun K Sharma; Fiscal Year: 2010
    ..study involving naturally occurring and synthetic isothiocyanates and corresponding newly developed selenium analogs, the isoselenocyanates, have identified phenylbutyl isoselenocyanate (ISC-4;Ph-(CH2)4-N=C=Se) as the most ..
  43. Prevention of PTEN deletion driven prostate cancer by selenium
    Junxuan Lu; Fiscal Year: 2012
    ..Previous studies have suggested that supplementation of selenium (Se) may prevent or delay human PCa...
  44. Expanding The Genetic Code In Yeast
    Paul R Copeland; Fiscal Year: 2013
    ..g. fluorescent) amino acids. In addition to the major impact on selenium biology, this project will also provide valuable resources for scientific disciplines that require the analysis ..
  45. An unexpected role for elF4a3 in regulating GPx1 selenoprotein expression
    MICHAEL EVEREST BUDIMAN; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): Selenium deficiency, which ultimately leads to the reduction of selenoprotein expression, has been associated with many diseases, including but not limited to viral infection, reproductive dysfunction,..
  46. PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research
    Ian M Thompson; Fiscal Year: 2013
    ..Center in Seattle served as the coordinating center for two large prostate cancer prevention trials, the Selenium and Vitamin E Cancer Prevention Trial (SELECT) and the Prostate Cancer Prevention Trial (PCPT)...
  47. Gpx3 Targeting and Extracellular Oxidative Stress
    Raymond F Burk; Fiscal Year: 2012
    ..We have also shown that Gpx3 is not involved in the regulated transport of selenium. We hypothesize that Gpx3 protects basement membranes and their associated epithelial cells in kidney and ..
  48. Oxidative Stress, Antioxidants and Racial Disparities in Prostate Cancer
    Cathryn H Bock; Fiscal Year: 2011
    ..variation in these genes modifies prostate cancer risk associated with intake of the antioxidants vitamin E, selenium and lycopene...
  49. Functions of thioredoxin reductases and their targets
    Vadim N Gladyshev; Fiscal Year: 2013
    ..selenocysteine in the C-terminal region and, therefore, the mammalian Trx system is dependent on dietary selenium. In addition, each TR has several isoforms that differ by their N-terminal sequences...
  50. Influence of Dietary Fish and mercury Exposure on Brain health and Dementia
    Martha Clare Morris; Fiscal Year: 2013
    ..study, the Memory and Aging Project (MAP) to examine whether brain levels of mercury (Hg) and selenium (Se) are related to brain neuropathology (A[unreadable], neurofibrillary tangles, cerebral infarcts, Lewy bodies),..
  51. Identity and Function of Selenoprotein Genes
    Vadim N Gladyshev; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium is an essential trace element that has roles in cancer prevention, the immune system, brain function, and male reproduction...
  52. Inhibition of Biofilms on Tympanostomy Tubes
    Ted W Reid; Fiscal Year: 2010
    ..Recently we showed that the covalent attachment of micrograms of organo-selenium to the surface of an orthodontic device will inhibit the formation of a biofilm without harmful side-effects...
  53. Regulation of Selenoprotein Synthesis by SECIS-binding Proteins
    Donna M Driscoll; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium is an essential micronutrient that exerts many important health benefits. The element is incorporated into selenoproteins as selenocysteine (Sec)...
  54. Functional analysis of SBP2 and selenocysteine incorporation
    Paul R Copeland; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium is an essential component of the human diet because it is incorporated into at least 25 human proteins whose functions are required for key elements in human health, including the regulation ..
  55. NUTRITIONAL AND METABOLIC SIGNIFICANCE OF SELENIUM
    Raymond F Burk; Fiscal Year: 2013
    The nutritional effects of selenium depend on selenoproteins. Selenoprotein P (Se-P) is an extracellular selenoprotein that has been postulated to transport the element from the liver to other tissues...
  56. Trace element levels and risk of stroke
    Leslie Ain McClure; Fiscal Year: 2013
    ..The proposed study will focus on arsenic, cadmium, mercury, magnesium and selenium. Specifically, we will characterize the distribution of trace element levels measured in urine or serum according ..
  57. Viral Adaptation to Host Selenium Status
    Melinda A Beck; Fiscal Year: 2012
    ..Previous work in our laboratory has demonstrated that a human isolate of coxsackievirus B3 replicating in a selenium deficient animal develops specific viral mutations...
  58. Mechanisms by which selenium influences T helper cells during immune responses
    Peter R Hoffmann; Fiscal Year: 2010
    The immune-enhancing effects of selenium (Se) supplementation make it a promising complementary and alternative medicine (CAM) modality for boosting immunity against common colds, influenza, and vaccinations...
  59. Functions of Mammalian thioredoxin reductases
    VADIM GLADYSHEV; Fiscal Year: 2009
    ..is dependent on a selenocysteine residue, whose biosynthesis in turn is affected by the availability of dietary selenium. Mammals contain three selenoprotein thioredoxin reductase isozymes, TR1, TR3 and TGR, which occur in multiple ..
  60. ANDROGEN RECEPTOR SIGNALING IN SELENIUM CHEMOPREVENTION
    Yan Dong; Fiscal Year: 2009
    ..This project will focus on the investigation of molecular mechanism of selenium chemoprevention of prostate cancer...
  61. FASEB SRC 2012 on Trace Elements in Biology and Medicine
    Dennis R Winge; Fiscal Year: 2012
    ..research findings from cutting-edge investigations related to metabolism of iron (Fe), zinc (Zn), copper (Cu) and selenium (Se) and their role in human health and disease...
  62. Selenium Coated Dialysis Catheters for Reduced Biofilm Formation
    Eric Tobin; Fiscal Year: 2009
    ..This grant is evaluating the hypothesis that a covalently attached selenium coating can reduce bacterial colonization and biofilm formation on the surface of dialysis catheters, thereby ..
  63. Selenoproteins as Targets for Cancer Prevention
    Vadim N Gladyshev; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Selenium (Se) is an essential trace element in human nutrition due to its presence, in the form of selenocysteine residue, in 25 selenoproteins...
  64. Supplemental Se and Vitamin E and Pulmonary Function
    PATRICIA CASSANO; Fiscal Year: 2007
    This proposed project is a randomized clinical trial testing whether supplementation with selenium and/or vitamin E affects pulmonary function...
  65. CANCER PREVENTION BY SELENIUM-ENRICHED ALLIUM VEGETABLES
    Clement Ip; Fiscal Year: 2003
    This project is focused on the mammary cancer preventive activity of a high-selenium garlic (abbreviated to Se-garlic)...
  66. GLUTATHIONE PEROXIDASE ACTION AND INHIBITION
    PETER GETTINS; Fiscal Year: 1990
    b>Selenium is an essential nutrient for man, in large part through the crucial part it plays in the mechanism of action of glutathione peroxidase...
  67. Oxidative Stress in Alcoholic Cardiomyopathy
    Charles Lui; Fiscal Year: 2004
    ..Since selenium and vitamin deficiencies are common among alcoholics, possibly as a result of malnutrition and/or malabsorption, ..
  68. Selenium, Glutathione Peroxidase-1, and Homocysteine-induced Cardiac Remodeling
    Jacob Joseph; Fiscal Year: 2009
    ..Dietary selenium is a potential major modulator of Hhe-induced myocardial fibrosis, since a major cellular defense against oxidant ..
  69. Impact of Arsenicals on Selenoprotein Synthesis
    William Self; Fiscal Year: 2006
    ..b>Selenium, a required micronutrient for mammalian cell growth and survival, is a component of several critical enzymes (..
  70. Selenium against arsenic toxicity and skin lesions
    JULIAN SPALLHOLZ; Fiscal Year: 2005
    ..double-blinded, placebo-controlled Phase III clinical intervention trial to assess the efficacy of dietary selenium supplements in reducing arsenic body load and in arresting the growth of cancer-associated skin lesions...
  71. Selenium and colorectal adenomas and adenocarcinomas
    Alexandra Connelly; Fiscal Year: 2003
    ..b>Selenium, an essential trace element found in cereals, wheat, dairy products, meat and fish, may prevent carcinogenesis ..
  72. Efficient Synthesis of Se-DNAs and Se-RNAs for Structure and Function Studies
    Zhen Huang; Fiscal Year: 2010
    ..and successfully demonstrated a novel derivatization strategy via replacement of oxygen of nucleic acids with selenium. Their research is based on their central hypothesis that since oxygen and selenium are in the same elemental ..
  73. Development of Novel Methods to Reduce Ghosting and Lag in a-Se X-ray Detectors
    DENNY LEE; Fiscal Year: 2009
    ..Technology (DXT) was formed in April of 2006, with a goal to introduce advanced technology developments for selenium detectors in x-ray imaging...
  74. SELENIUM AND LUNG CANCER RISK
    Henry Thompson; Fiscal Year: 2004
    ..placebo-controlled clinical intervention study, the goal of which is to evaluate the chemopreventive activity of selenium against lung cancer in a population of asbestos exposed individuals...
  75. DETERMINATION OF SELENIUM IN CARDIAC BIOPSY SAMPLES
    James Williams; Fiscal Year: 1990
    ..to develop an analytical method which is sufficiently sensitive and accurate to support a study of the role of selenium in dilated cardiomyopathy, and to conduct the actual analyses of heart biopsy samples collected by Dr...