durapatite

Summary

Summary: The mineral component of bones and teeth; it has been used therapeutically as a prosthetic aid and in the prevention and treatment of osteoporosis.

Top Publications

  1. ncbi Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Huanan Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
    Biomaterials 28:3338-48. 2007
  2. ncbi Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals
    Jason O'Young
    School of Dentistry, University of Western Ontario, London, Canada
    J Am Chem Soc 133:18406-12. 2011
  3. pmc Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures
    Wender Figved
    Orthopaedic Centre, Ulleval University Hospital, Oslo, Norway
    Clin Orthop Relat Res 467:2426-35. 2009
  4. ncbi Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells
    S P Bruder
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    J Orthop Res 16:155-62. 1998
  5. pmc Hip arthroplasty in patients younger than 30 years: excellent ten to 16-year follow-up results with a HA-coated stem
    H Wangen
    Department of Orthopaedics, Rikshospitalet Radiumhospitalet Medical Centre, 0027, Oslo, Norway
    Int Orthop 32:203-8. 2008
  6. ncbi Tissue engineering of bone: search for a better scaffold
    M Mastrogiacomo
    Dipartimento di Oncologia, Biologia e Genetica, Istituto Nazionale per la Ricerca sul Cancro, dell Universita di Genova, Italy
    Orthod Craniofac Res 8:277-84. 2005
  7. pmc Connective tissue mineralization in Abcc6-/- mice, a model for pseudoxanthoma elasticum
    N Beril Kavukcuoglu
    Department of Bioengineering, Temple University, Philadelphia, PA 19122, USA
    Matrix Biol 31:246-52. 2012
  8. ncbi Recent advances in research applications of nanophase hydroxyapatite
    Kate Fox
    School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia
    Chemphyschem 13:2495-506. 2012
  9. ncbi The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture
    Shinichi Maeno
    Department of Orthopaedic Surgery, Keio University Hospital, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    Biomaterials 26:4847-55. 2005
  10. ncbi On implant surfaces: a review of current knowledge and opinions
    Ann Wennerberg
    Department of Prosthodontics, Malmo University, Sweden
    Int J Oral Maxillofac Implants 25:63-74. 2010

Research Grants

Detail Information

Publications321 found, 100 shown here

  1. ncbi Biocompatibility and osteogenesis of biomimetic nano-hydroxyapatite/polyamide composite scaffolds for bone tissue engineering
    Huanan Wang
    Research Center for Nano Biomaterials, Analytical and Testing Center, Sichuan University, Chengdu, 610064, PR China
    Biomaterials 28:3338-48. 2007
    ..All these results indicate that the scaffolds fulfill the basic requirements of bone tissue engineering scaffold, and have the potential to be applied in orthopedic, reconstructive and maxillofacial surgery...
  2. ncbi Matrix Gla protein inhibits ectopic calcification by a direct interaction with hydroxyapatite crystals
    Jason O'Young
    School of Dentistry, University of Western Ontario, London, Canada
    J Am Chem Soc 133:18406-12. 2011
    ..The strong correlation between simulated adsorption and measured growth inhibition indicates that MD provides a powerful tool to predict the effects of proteins and peptides on crystal formation...
  3. pmc Cemented versus uncemented hemiarthroplasty for displaced femoral neck fractures
    Wender Figved
    Orthopaedic Centre, Ulleval University Hospital, Oslo, Norway
    Clin Orthop Relat Res 467:2426-35. 2009
    ..The rates of complications and mortality were similar between groups. Both arthroplasties may be used with good results after displaced femoral neck fractures...
  4. ncbi Bone regeneration by implantation of purified, culture-expanded human mesenchymal stem cells
    S P Bruder
    Osiris Therapeutics, Baltimore, Maryland 21231, USA
    J Orthop Res 16:155-62. 1998
    ..These studies demonstrate that human mesenchymal stem cells can regenerate bone in a clinically significant osseous defect and may therefore provide an alternative to autogenous bone grafts...
  5. pmc Hip arthroplasty in patients younger than 30 years: excellent ten to 16-year follow-up results with a HA-coated stem
    H Wangen
    Department of Orthopaedics, Rikshospitalet Radiumhospitalet Medical Centre, 0027, Oslo, Norway
    Int Orthop 32:203-8. 2008
    ..In conclusion, we found mechanical failures at the acetabular side, but excellent results with a fully HA-coated femoral stem, with no revisions after ten to 16 years...
  6. ncbi Tissue engineering of bone: search for a better scaffold
    M Mastrogiacomo
    Dipartimento di Oncologia, Biologia e Genetica, Istituto Nazionale per la Ricerca sul Cancro, dell Universita di Genova, Italy
    Orthod Craniofac Res 8:277-84. 2005
    ..Different sources of osteoprogenitor cells have been suggested, bone marrow stromal cells (BMSC) being in most cases the first choice...
  7. pmc Connective tissue mineralization in Abcc6-/- mice, a model for pseudoxanthoma elasticum
    N Beril Kavukcuoglu
    Department of Bioengineering, Temple University, Philadelphia, PA 19122, USA
    Matrix Biol 31:246-52. 2012
    ..These results provide critical information of the mechanisms of mineralization in PXE, with potential pharmacologic implications...
  8. ncbi Recent advances in research applications of nanophase hydroxyapatite
    Kate Fox
    School of Physics, University of Melbourne, Parkville, Victoria 3010, Australia
    Chemphyschem 13:2495-506. 2012
    ..Synthesis routes and a wide range of applications of hydroxyapatite nanoparticles will be discussed. The Minireview also addresses several challenges concerning the biosafety of the nanoparticles...
  9. ncbi The effect of calcium ion concentration on osteoblast viability, proliferation and differentiation in monolayer and 3D culture
    Shinichi Maeno
    Department of Orthopaedic Surgery, Keio University Hospital, 35 Shinanomachi, Shinjukuku, Tokyo 160 8582, Japan
    Biomaterials 26:4847-55. 2005
    ..Considering the viability of embedded cells, culturing scaffolds in media with Ca2+ concentrations around 5mM is useful for both HAp deposition and osteoblast behavior...
  10. ncbi On implant surfaces: a review of current knowledge and opinions
    Ann Wennerberg
    Department of Prosthodontics, Malmo University, Sweden
    Int J Oral Maxillofac Implants 25:63-74. 2010
    ....
  11. pmc Electrophoretic deposition of biomaterials
    A R Boccaccini
    Institute of Biomaterials, Department of Materials Science and Engineering, University of Erlangen Nuremberg, Erlangen, Germany
    J R Soc Interface 7:S581-613. 2010
    ....
  12. ncbi Orthopaedic applications of bone graft & graft substitutes: a review
    S K Nandi
    Department of Veterinary Surgery and Radiology, West Bengal University of Animal and Fishery Sciences, Kolkata, India
    Indian J Med Res 132:15-30. 2010
    ..We review the currently available bone graft and graft substitutes for the novel therapeutic approaches in clinical setting of orthopaedic surgery...
  13. ncbi Dose-dependent osteogenic effect of octacalcium phosphate on mouse bone marrow stromal cells
    Takahisa Anada
    Division of Craniofacial Function Engineering, Tohoku University Graduate School of Dentistry, Sendai, Japan
    Tissue Eng Part A 14:965-78. 2008
    ....
  14. pmc In vitro and in vivo evaluations of nano-hydroxyapatite/polyamide 66/glass fibre (n-HA/PA66/GF) as a novel bioactive bone screw
    Bao Su
    Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China
    PLoS ONE 8:e68342. 2013
    ..As shown by their good cytocompatibility, excellent biomechanical strength and fast formation and ingrowth of new bone, n-HA/PA66/GF screws are thus suitable for orthopaedic clinical applications. ..
  15. ncbi Integrated biomimetic carbon nanotube composites for in vivo systems
    Manoj Kumar Singh
    Nanotechnology Research Division, Center for Mechanical Technology and Automation, University of Aveiro, 3810 193, Aveiro, Portugal
    Nanoscale 2:2855-63. 2010
    ..We believe that these results will have applications in a diversity of areas including carbon nanotube, regeneration, chemistry, and engineering research...
  16. ncbi The effect of hydroxyapatite on the micromotion of total knee prostheses. A prospective, randomized, double-blind study
    R G Nelissen
    Department of Orthopaedic Surgery, Leiden University Medical Centre, The Netherlands
    J Bone Joint Surg Am 80:1665-72. 1998
    ..Therefore, hydroxyapatite, a biological mediator, may be necessary for the adequate fixation of tibial components when cement is not used...
  17. ncbi Intrinsic magnetism and hyperthermia in bioactive Fe-doped hydroxyapatite
    Anna Tampieri
    Institute of Science and Technology for Ceramics National Research Council, Faenza RA 48018, Italy
    Acta Biomater 8:843-51. 2012
    ..This result potentially opens new perspectives for biodevices aimed at bone regeneration and for anti-cancer therapies based on hyperthermia...
  18. ncbi The Otto Aufranc Award: bone augmentation around and within porous implants by local bisphosphonate elution
    Michael Tanzer
    Department of Surgery, McGill University, Montreal, Quebec, Canada
    Clin Orthop Relat Res 441:30-9. 2005
    ..The concept represents a potential tool for restoration of bone stock and enhancement of implant fixation in primary and revision cementless joint arthroplasty surgeries in the face of compromised or deficient bone...
  19. ncbi The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating
    Thomas Crouzier
    LMGP, UMR 5628 CNRS INPG, 3 parvis Louis Neel, 38016 Grenoble, France
    Biomaterials 32:7543-54. 2011
    ..This opens perspective for coating these bioactive PEM on other types of implantable materials, including metal alloy that do not exhibit any affinity for rhBMP-2...
  20. ncbi Hydroxyapatite-coated carboxymethyl chitosan scaffolds for promoting osteoblast and stem cell differentiation
    Rusdianto Budiraharjo
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore
    J Colloid Interface Sci 366:224-32. 2012
    ..On the other hand, high HAP coverage was beneficial in stimulating osteoblast attachment and proliferation. This study demonstrates the good potential of HAP-coated CMCS scaffolds as osteogenic scaffolds to stimulate bone healing...
  21. ncbi Long-term results of the ABG-1 hydroxyapatite coated total hip arthroplasty: analysis of 111 cases with a minimum follow-up of 10 years
    R Bidar
    Department of Orthopaedics and Traumatology, Carémeau Teaching Hospital Center, place du Pr Robert Debré, 30029 Nimes Cedex 9, France
    Orthop Traumatol Surg Res 95:579-87. 2009
    ....
  22. ncbi In vivo evaluation of resorbable bone graft substitutes in a rabbit tibial defect model
    D Stubbs
    Orthopaedic Research Laboratories, University of New South Wales, Division of Surgery, Prince of Wales Hospital, Sydney, High Street, Randwick, NSW 2031, Australia
    Biomaterials 25:5037-44. 2004
    ....
  23. ncbi 3D microenvironment as essential element for osteoinduction by biomaterials
    Pamela Habibovic
    Institute for Biomedical Technology, Twente University, Department Bilthoven, Professor Bronkhorstlaan 10 D, Bilthoven, 3723 MB, The Netherlands
    Biomaterials 26:3565-75. 2005
    ....
  24. pmc The effect of RGD peptides on osseointegration of hydroxyapatite biomaterials
    Kristin M Hennessy
    Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Biomaterials 29:3075-83. 2008
    ....
  25. ncbi Uncemented HA-coated implant is the optimum fixation for TKA in the young patient
    Kjell G Nilsson
    Department of Orthopaedics, Umea University Hospital, Sweden
    Clin Orthop Relat Res 448:129-39. 2006
    ..Uncemented fixation using hydroxyapatite-coated implants without screws seems to be the best solution for the younger patient...
  26. ncbi Osteoblast growth and function in porous poly epsilon -caprolactone matrices for bone repair: a preliminary study
    G Ciapetti
    Laboratorio di Fisiopatologia degli Impianti Ortopedici, Istituto Ortopedico Rizzoli, Via Di Barbiano 1 10, 40139, Bologna, Italy
    Biomaterials 24:3815-24. 2003
    ..It can be concluded that PCL is a promising material for three-dimensional scaffold for bone formation, and the presence of bone-like components improves osteoblast activity...
  27. ncbi Development of biomimetic nano-hydroxyapatite/poly(hexamethylene adipamide) composites
    Xuejiang Wang
    Institute of Materials Science and Technology, Sichuan University, 610064 Chengdu, China
    Biomaterials 23:4787-91. 2002
    ..Chemical binding between inorganic n-HA and polyamide was investigated and discussed. The mechanical properties of the composites were found to match well with those of natural bone...
  28. ncbi The fabrication of nano-hydroxyapatite on PLGA and PLGA/collagen nanofibrous composite scaffolds and their effects in osteoblastic behavior for bone tissue engineering
    Michelle Ngiam
    National University of Singapore Graduate School NGS for Integrative Sciences and Engineering, Centre for Life Sciences, Singapore
    Bone 45:4-16. 2009
    ..The amount of n-HA appeared to have a greater effect on the early stages of osteoblast behavior (cell attachment and proliferation) rather than the immediate/late stages (proliferation and differentiation)...
  29. ncbi Healing of intrabony peri-implantitis defects following application of a nanocrystalline hydroxyapatite (Ostim) or a bovine-derived xenograft (Bio-Oss) in combination with a collagen membrane (Bio-Gide). A case series
    F Schwarz
    Department of Oral Surgery, Heinrich Heine University, Dusseldorf, Germany
    J Clin Periodontol 33:491-9. 2006
    ....
  30. ncbi Cemented tibial component fixation performs better than cementless fixation: a randomized radiostereometric study comparing porous-coated, hydroxyapatite-coated and cemented tibial components over 5 years
    Ake Carlsson
    Department of Orthopedicsy, Malmo University Hospital, SE 205 02 Malmo, Sweden
    Acta Orthop 76:362-9. 2005
    ....
  31. pmc Importance of phosphorylation for osteopontin regulation of biomineralization
    A Gericke
    Department of Chemistry, Kent State University, Kent, OH, USA
    Calcif Tissue Int 77:45-54. 2005
    ..These data taken together suggest that the phosphorylation of OPN is an important factor in regulating the OPN-mediated mineralization process...
  32. ncbi Paramagnetic nanofibrous composite films enhance the osteogenic responses of pre-osteoblast cells
    Jie Meng
    Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Nanoscale 2:2565-9. 2010
    ....
  33. ncbi Biomedical applications of hydroxyapatite nanoparticles
    S C J Loo
    Department of Bioengineering, Rhodes Research Center, 203, Clemson University, Clemson, South Carolina 29634, USA
    Curr Pharm Biotechnol 11:333-42. 2010
    ....
  34. ncbi A preliminary study in osteoinduction by a nano-crystalline hydroxyapatite in the mini pig
    Werner Gotz
    Dept of Orthodontics, Oral Biology Laboratory, University of Bonn, Dental Hospital, Bonn, Germany
    Folia Histochem Cytobiol 48:589-96. 2010
    ..The results of this preliminary study indicate that this biomaterial has osteoinductive potential and induces the formation of bone structures, mainly in subcutaneous adipose tissue in the pig...
  35. ncbi Bioresorbable composite bone paste using polysaccharide based nano hydroxyapatite
    R Murugan
    Nanobioengineering Laboratory, Division of Bioengineering, Department of Mechanical Engineering, NUS Nanoscience and Nanotechnology Initiative, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore
    Biomaterials 25:3829-35. 2004
    ..These findings suggest that the HA/chitosan composites may have a great impact on human health care systems as bioresorbable bone substitute...
  36. pmc In vivo behaviour of low-temperature calcium-deficient hydroxyapatite: comparison with deproteinised bovine bone
    Pavel Sponer
    Department of Orthopaedic Surgery, Faculty of Medicine and University Hospital in Hradec Kralove, Charles University in Prague, Sokolska 581, 500 05, Hradec Kralove, Czech Republic
    Int Orthop 35:1553-60. 2011
    ..The favourable influence of a high specific surface area of a low-temperature calcium-deficient hydroxyapatite on in vivo bone formation was emphasized...
  37. ncbi Improvement on the performance of bone regeneration of calcium sulfate hemihydrate by adding mineralized collagen
    Huan Ye Liu
    Department of Prosthodontics, School of Stomatology, China Medical University, Shenyang, China
    Tissue Eng Part A 16:2075-84. 2010
    ..This result means that nHAC/CSH could cause an earlier accelerator and better osseointegration for bone repair than CSH only...
  38. pmc Preliminary biocompatible evaluation of nano-hydroxyapatite/polyamide 66 composite porous membrane
    Yili Qu
    State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610064, China
    Int J Nanomedicine 5:429-35. 2010
    ..In conclusion, the results of the in vitro and in vivo studies reveal that nHA/PA66 membrane has excellent biocompatibility and indicate its use in guided tissue regeneration (GTR) or GBR...
  39. ncbi Structure and properties of nano-hydroxyapatite/polymer composite scaffolds for bone tissue engineering
    Guobao Wei
    Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI 48109 2009, USA
    Biomaterials 25:4749-57. 2004
    ..The results suggest that the newly developed NHAP/polymer composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering...
  40. ncbi Effect of thin nano-hydroxyapatite coating on implant osseointegration in ovariectomized rats
    Zhipeng Cheng
    Department of Implantology, Stomatology Hospital, School of Medical, Zhejiang University, Yan An Road, Hangzhou, China
    Oral Surg Oral Med Oral Pathol Oral Radiol 113:e48-53. 2012
    ..The purpose of this study was to investigate the effect of the thin nano-hydroxyapatite (nano-HA) coating on implant osseointegration in an ovariectomized rat model...
  41. ncbi Prediction of mechanical properties of composites of HDPE/HA/EAA
    C Albano
    Universidad Central de Venezuela, Facultad de Ingenieria, Escuela de Ingeniería Química, Caracas, Venezuela
    J Mech Behav Biomed Mater 4:467-75. 2011
    ..In composites with 20 and 30 wt% of filler, this interaction does not improve the Young's modulus values, since the deviations of the Verbeek model are significant...
  42. ncbi Adsorption and spectroscopic characterization of lactoferrin on hydroxyapatite nanocrystals
    Michele Iafisco
    Dipartimento di Chimica G Ciamician, Alma Mater Studiorum Universita di Bologna, Via Selmi 2, 40126, Bologna, Italy
    Dalton Trans 40:820-7. 2011
    ..The bioactive surface of HA functionalized with LF could be utilized to improve the material performance towards the biological environment for biomedical applications...
  43. ncbi Stimulation of osteoblast responses to biomimetic nanocomposites of gelatin-hydroxyapatite for tissue engineering scaffolds
    Hae won Kim
    School of Materials Science and Engineering, Seoul National University, Seoul 151 742, Republic of Korea
    Biomaterials 26:5221-30. 2005
    ..Based on these findings, the biomimetically synthesized nanocomposite scaffolds are believed to be potentially useful in hard tissue regeneration and tissue engineering fields...
  44. ncbi Biomimetic hydroxyapatite-containing composite nanofibrous substrates for bone tissue engineering
    J Venugopal
    Nanoscience and Nanotechnology Initiative, Faculty of Engineering, National University of Singapore, Block E3 05 12, 2 Engineering Drive 3, Singapore 117576, Republic of Singapore
    Philos Trans A Math Phys Eng Sci 368:2065-81. 2010
    ..The present review is intended to direct the reader's attention to the important subjects of synthetic and natural polymers with HA for bone tissue engineering...
  45. ncbi A new uncemented hydroxyapatite-coated femoral component for the treatment of femoral neck fractures: two-year radiostereometric and bone densitometric evaluation in 50 hips
    O G Sköldenberg
    Department of Clinical Sciences, Division of Orthopaedics, Karolinska Institute at Danderyd Hospital, S 18288 Stockholm, Sweden
    J Bone Joint Surg Br 93:665-77. 2011
    ..The two-year results from this pilot study indicate that this new, uncemented femoral component can be used for elderly patients with osteoporotic fractures of the femoral neck...
  46. pmc Effects of hydroxyapatite coating on survival of an uncemented femoral stem. A Swedish Hip Arthroplasty Register study on 4,772 hips
    Stergios Lazarinis
    Department of Orthopaedics, Institute of Surgical Sciences, Uppsala University Hospital, Uppsala, Sweden
    Acta Orthop 82:399-404. 2011
    ..However, the evidence behind the use of HA coating on femoral stems is ambiguous. We investigated survival of an uncemented, tapered titanium femoral stem that was available either with or without HA coating (Bi-Metric)...
  47. ncbi The mechanical properties and osteoconductivity of hydroxyapatite bone scaffolds with multi-scale porosity
    Joseph R Woodard
    Department of Mechanical and Industrial Engineering, University of Illinois at Urbana Champaign, 1206 W Green St, Urbana, IL 61801, USA
    Biomaterials 28:45-54. 2007
    ..The change in mechanical behavior is discussed and the study demonstrates the importance of scaffold microporosity on bone ingrowth and on the mechanical behavior of HA implant materials...
  48. ncbi In vivo study on hydroxyapatite scaffolds with trabecular architecture for bone repair
    Mark R Appleford
    Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas 78249, USA
    J Biomed Mater Res A 89:1019-27. 2009
    ..This study demonstrated the potential of trabecular bone modeled, highly porous and interconnected, HA scaffolds for regenerative orthopedics...
  49. ncbi Synthesis and characterisation of nanohydroxyapatite using an ultrasound assisted method
    Gérard Eddy Poinern
    Murdoch Applied Nanotechnology Research Group, Department of Physics, Energy Studies and Nanoscience, School of Engineering and Energy, Murdoch University, Murdoch, Western Australia 6150, Australia
    Ultrason Sonochem 16:469-74. 2009
    ..The results showed that Nano-HAP can be obtained by this method and the particles were achieved to around 30 nm...
  50. ncbi Preparation and preliminary studies on 177Lu-labeled hydroxyapatite particles for possible use in the therapy of liver cancer
    Sudipta Chakraborty
    Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai, India
    Nucl Med Biol 35:589-97. 2008
    ..Hydroxyapatite (HA) particles of 20-60 microm size range are chosen as the particulate carrier due to its excellent biocompatibility and ease of labeling with lanthanides...
  51. ncbi Biocompatibility and osteogenicity of degradable Ca-deficient hydroxyapatite scaffolds from calcium phosphate cement for bone tissue engineering
    Han Guo
    Key Laboratory for Ultrafine Materials of Ministry of Education, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China
    Acta Biomater 5:268-78. 2009
    ..However, the CDHA scaffolds showed as good biocompatibility and osteogenicity as the hybrid ones at 8 weeks. These results indicate that the CDHA scaffolds fulfill the basic requirements of bone tissue engineering scaffold...
  52. ncbi Hydroxyapatite nanoparticles as vectors for gene delivery
    Thi Ngoc Tram Do
    Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia
    Ther Deliv 3:623-32. 2012
    ....
  53. ncbi Immunohistochemical characterization of nanocrystalline hydroxyapatite silica gel (NanoBone(r)) osteogenesis: a study on biopsies from human jaws
    Werner Gotz
    Department of Orthodontics, Oral Biology Laboratory, University of Bonn, Dental Hospital, Bonn, Germany
    Clin Oral Implants Res 19:1016-26. 2008
    ..5 and 12 months...
  54. pmc Nanocalcium-deficient hydroxyapatite-poly (e-caprolactone)-polyethylene glycol-poly (e-caprolactone) composite scaffolds
    Zhiwei Wang
    Department of Orthopedics, Shanghai Hospital, Second Military Medical University, Shanghai, People s Republic of China
    Int J Nanomedicine 7:3123-31. 2012
    ..The results suggested that the n-CDAP-based composite exhibits good biocompatibility, biodegradation, and osteogenesis in vivo...
  55. ncbi In vivo analysis of biocompatibility and vascularization of the synthetic bone grafting substitute NanoBone
    K Abshagen
    Institute for Experimental Surgery, University of Rostock, Rostock, Germany
    J Biomed Mater Res A 91:557-66. 2009
    ..Our results underline that, beside the composition and nanostructure, the macrostructure is also of importance for the incorporation of the biomaterial by the host tissue...
  56. pmc Electrospun hydroxyapatite-containing chitosan nanofibers crosslinked with genipin for bone tissue engineering
    Michael E Frohbergh
    Drexel University, School of Biomedical Engineering, Science and Health System, Philadelphia, PA, USA
    Biomaterials 33:9167-78. 2012
    ..Such scaffolds will facilitate the proliferation, differentiation and maturation of osteoblast-like cells. We propose that these scaffolds might be useful for the repair and regeneration of maxillofacial defects and injuries...
  57. ncbi Effect of combined local treatment with zoledronic acid and basic fibroblast growth factor on implant fixation in ovariectomized rats
    Ying Gao
    State Key Laboratory of Oral Diseases and Department of Oral and Maxillofacial Surgery, Sichuan University West China College of Stomatology, Chengdu, China
    Bone 44:225-32. 2009
    ....
  58. ncbi Nano-analytical electron microscopy reveals fundamental insights into human cardiovascular tissue calcification
    Sergio Bertazzo
    Department of Materials, Imperial College London, London, UK
    Nat Mater 12:576-83. 2013
    ..Indeed, applying materials science techniques to ectopic and orthotopic calcification has great potential to lend critical insights into pathophysiological processes underlying calcific cardiovascular disease...
  59. ncbi Mechanical properties and in vitro bioactivity of injectable and self-setting calcium sulfate/nano-HA/collagen bone graft substitute
    Ning Min Hu
    Department of Orthopaedic Surgerg, General Hospital, Ningxia Medical University, Yinchuan 750004, PR China
    J Mech Behav Biomed Mater 12:119-28. 2012
    ..In vitro cell behavior demonstrated that the composites could provide adequate environment for cell adhesion and proliferation. All these indicated that the nHAC/CSH composites were a potential scaffold for bone tissue engineering...
  60. pmc Degradable biocomposite of nano calcium-deficient hydroxyapatite-multi(amino acid) copolymer
    Hong Li
    School of Physical Science and Technology, Sichuan University, Chengdu, People s Republic of China
    Int J Nanomedicine 7:1287-95. 2012
    ..The composition, structure, and compressive strength of the composite was characterized, and the in vitro degradability in phosphate-buffered solution and preliminary cell responses to the composite were investigated...
  61. ncbi Osteotomy of distal radius fracture malunion using a fast remodeling bone substitute consisting of calcium sulphate and calcium phosphate
    Antonio Abramo
    Department of Orthopaedics, Clinical Sciences, Lund University, Lund, Sweden
    J Biomed Mater Res B Appl Biomater 92:281-6. 2010
    ..A more rigid fixation may improve the radiographic outcome with this kind of bone substitute...
  62. ncbi Amino acid synergetic effect on structure, morphology and surface properties of biomimetic apatite nanocrystals
    Barbara Palazzo
    Department of Chemistry G Ciamician, Alma Mater Studiorum, University of Bologna, Via Selmi 2, 40126 Bologna, Italy
    Acta Biomater 5:1241-52. 2009
    ....
  63. ncbi Fabrication and characterization of PLGA/HAp composite scaffolds for delivery of BMP-2 plasmid DNA
    Hemin Nie
    Department of Chemical and Biomolecular Engineering, National University of Singapore, Singapore, Singapore
    J Control Release 120:111-21. 2007
    ..The observations show that DNA/chitosan nanoparticles encapsulated PLGA/HAp composite scaffold is promising for use in bone regeneration...
  64. ncbi Superior in vitro biological response and mechanical properties of an implantable nanostructured biomaterial: Nanohydroxyapatite-silicone rubber composite
    W W Thein-Han
    Biomaterials and Biomedical Engineering Research Laboratory, Center for Structural and Functional Materials, University of Louisiana at Lafayette, P O Box 44130, Lafayette, LA 70504, USA
    Acta Biomater 5:2668-79. 2009
    ..The integration of cellular and molecular biology with materials science and engineering described herein provides a direction for the development of a new generation of nanostructured materials...
  65. ncbi Repair of rat cranial bone defects with nHAC/PLLA and BMP-2-related peptide or rhBMP-2
    Jingfeng Li
    Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, People s Republic of China
    J Orthop Res 29:1745-52. 2011
    ..The osteoinductive ability of 3 mg P24 was similar to that of 1 µg rhBMP-2. P24/nHAC/PLLA is a promising scaffold biomaterial for bone tissue regeneration...
  66. ncbi A hollow cylindrical nano-hydroxyapatite/polyamide composite strut for cervical reconstruction after cervical corpectomy
    Zenghui Zhao
    Department of Orthopedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Yuzhong District, Chongqing 400016, China
    J Clin Neurosci 19:536-40. 2012
    ..We conclude that the n-HA/PA composite strut is scientifically and technically sound for cervical reconstruction and interbody fusion after corpectomy with anterior plate fixation...
  67. ncbi Hydroxyapatite nano and microparticles: correlation of particle properties with cytotoxicity and biostability
    M Motskin
    Multi Imaging Centre, School of Biological Sciences, Department of Physiology, Development and Neuroscience, Anatomy Building, Downing Street, Cambridge CB2 3DY, United Kingdom
    Biomaterials 30:3307-17. 2009
    ..Some HA NPs eluded the phagocytic pathway and a few were even seen to enter the nuclei through nuclear pores...
  68. ncbi The nanocomposite scaffold of poly(lactide-co-glycolide) and hydroxyapatite surface-grafted with L-lactic acid oligomer for bone repair
    Yang Cui
    State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Graduate School of Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, People s Republic of China
    Acta Biomater 5:2680-92. 2009
    ..All the data extrapolated that the composite with 10 and 20wt.% op-HA exhibited better comprehensive properties and were the optimal composites for bone repairing...
  69. ncbi Nanostructured biocomposite substrates by electrospinning and electrospraying for the mineralization of osteoblasts
    Deepika Gupta
    Nanoscience and Nanotechnology Initiative, National University of Singapore, Singapore
    Biomaterials 30:2085-94. 2009
    ....
  70. pmc Influence of hydroxyapatite-coated and growth factor-releasing interference screws on tendon-bone healing in an ovine model
    Yan Lu
    University of Wisconsin Madison, Madison, Wisconsin, USA
    Arthroscopy 25:1427-34.e1. 2009
    ....
  71. pmc Enhancement of periprosthetic bone quality with topical hydroxyapatite-bisphosphonate composite
    Sanjeev J Suratwala
    Center for Orthopaedic Research, Department of Orthopaedic Surgery, Columbia University, New York, NY 10032, USA
    J Bone Joint Surg Am 90:2189-96. 2008
    ....
  72. ncbi Cementless hemispheric hydroxyapatite-coated sockets for acetabular revision
    Carel H Geerdink
    Department of Orthopaedic Surgery and Traumatology, Atrium Medical Centre, CX Heerlen, The Netherlands
    J Arthroplasty 22:369-76. 2007
    ..5%-100%) and 98.1% (confidence interval, 94.5%-100%) when aseptic loosening of the cup is the end point. We conclude that hydroxyapatite-coated cups for acetabular revision show promising results...
  73. ncbi Poly(lactide-co-glycolide)/hydroxyapatite composite scaffolds for bone tissue engineering
    Sang Soo Kim
    Department of Bioengineering, Hanyang University, Seoul 133 791, Republic of Korea
    Biomaterials 27:1399-409. 2006
    ..These results show that the biodegradable polymer/bioceramic composite scaffolds fabricated by the novel GF/PL method enhance bone regeneration compared with those fabricated by the conventional SC/PL method...
  74. ncbi Preparation and properties of poly(lactide-co-glycolide) (PLGA)/ nano-hydroxyapatite (NHA) scaffolds by thermally induced phase separation and rabbit MSCs culture on scaffolds
    Y X Huang
    Institute of Nano and Bio Polymeric Materials, Tongji University, Shanghai 200092, PR China
    J Biomater Appl 22:409-32. 2008
    ..NHA. The results suggest that the newly developed PLGA/NHA composite scaffolds may serve as an excellent 3D substrate for cell attachment and migration in bone tissue engineering...
  75. ncbi Hydroxyapatite nanoparticles as a controlled-release carrier of BMP-2: absorption and release kinetics in vitro
    Guangping Xie
    Shanghai Biomaterials Research and Testing Center, Shanghai Ninth People s Hospital, Shanghai Jiaotong University School of Medicine, 200011 Shanghai, China
    J Mater Sci Mater Med 21:1875-80. 2010
    ..Collectively, these results suggest that HANPs has the potential to function as a carrier for drug delivery systems and as a scaffold material in bone tissue engineering...
  76. ncbi The use of a bioresorbable nano-crystalline hydroxyapatite paste in acetabular bone impaction grafting
    J J Chris Arts
    Orthopaedic Research Laboratory, Department Orthopaedics, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Biomaterials 27:1110-8. 2006
    ..In conclusion, Ostim HA-paste could be a valuable addition when TCP-HA ceramic granules are being used for acetabular bone impaction grafting procedures...
  77. ncbi Nano-hydroxyapatite/poly(L-lactic acid) composite synthesized by a modified in situ precipitation: preparation and properties
    C Y Zhang
    Key Laboratory of Materials Physics, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei, 230031, People s Republic of China
    J Mater Sci Mater Med 21:3077-83. 2010
    ..This supports the potential of these composites for applications in bone tissue engineering and load bearing bone defects repair...
  78. ncbi Accelerated mineralization of dense collagen-nano bioactive glass hybrid gels increases scaffold stiffness and regulates osteoblastic function
    Benedetto Marelli
    Department of Mining and Materials Engineering, McGill University, Montreal, QC, Canada
    Biomaterials 32:8915-26. 2011
    ..The accelerated mineralization of rapidly produced DC-nBG hybrid gels indicates their potential suitability as osteoinductive cell delivery scaffolds for bone regenerative therapy...
  79. ncbi The sequestration of hydroxyapatite nanoparticles by human monocyte-macrophages in a compartment that allows free diffusion with the extracellular environment
    Michael Motskin
    Multi Imaging Centre, Dept of Physiology, Development and Neuroscience, Anatomy Building, Cambridge University, Cambridge CB2 3DY, UK
    Biomaterials 32:9470-82. 2011
    ..We propose that SCC formation may be a means to remove large amounts of foreign material from the extracellular space, followed by slow degradation, may be to avoid excessive damage to surrounding cells or tissues...
  80. ncbi In vitro assessment of the differentiation potential of bone marrow-derived mesenchymal stem cells on genipin-chitosan conjugation scaffold with surface hydroxyapatite nanostructure for bone tissue engineering
    Guancong Wang
    Center of Bio and Micro nano Functional Materials, State Key Laboratory of Crystal Materials, Shandong University, Jinan, PR China
    Tissue Eng Part A 17:1341-9. 2011
    ..These findings open a new research avenue to controlling stem cell lineage commitment and provide a promising scaffold for bone tissue engineering...
  81. pmc NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy
    Chengcheng Jin
    Department of Immunobiology, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 108:14867-72. 2011
    ..These results demonstrate that the NLRP3 inflammasome mediates the pathological effect of HA crystals in vitro and in vivo and suggest a critical role for the inflammasome in the pathogenesis of OA...
  82. ncbi Various preparation methods of highly porous hydroxyapatite/polymer nanoscale biocomposites for bone regeneration
    Fangfang Sun
    Department of Nanomedical Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Miryang 627 706, Republic of Korea
    Acta Biomater 7:3813-28. 2011
    ..Finally, we provide a summary and our own perspectives on this active area of research...
  83. ncbi Point: Hydroxyapatite crystal deposition is intimately involved in the pathogenesis and progression of human osteoarthritis
    Geraldine M McCarthy
    Department of Medicine, University College Dublin and Mater Misericordiae University Hospital, Eccles St, Dublin 7, Ireland
    Curr Rheumatol Rep 11:141-7. 2009
    ..Enhanced effort is needed to establish calcium-containing crystals as a therapeutic target in OA, as current data suggest an intimate association in its pathogenesis and progression...
  84. ncbi Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy
    Hao Wang
    Department of Materials Science and Engineering, Massachusetts Institute of Technology, 77 Massachusetts Ave, Cambridge, and Tissue Engineering, VA Boston Healthcare System, MA 02139, USA
    Biomaterials 27:4192-203. 2006
    ....
  85. ncbi The chemical composition of synthetic bone substitutes influences tissue reactions in vivo: histological and histomorphometrical analysis of the cellular inflammatory response to hydroxyapatite, beta-tricalcium phosphate and biphasic calcium phosphate cer
    Shahram Ghanaati
    Institute of Pathology, University Medical Center of the Johannes Gutenberg University Mainz, Germany
    Biomed Mater 7:015005. 2012
    ..Both of these factors are necessary for successful bone tissue regeneration...
  86. pmc Increasing the pore sizes of bone-mimetic electrospun scaffolds comprised of polycaprolactone, collagen I and hydroxyapatite to enhance cell infiltration
    Matthew C Phipps
    University of Alabama at Birmingham, Department of Physiology and Biophysics, United States
    Biomaterials 33:524-34. 2012
    ....
  87. pmc Modular peptides promote human mesenchymal stem cell differentiation on biomaterial surfaces
    Jae Sam Lee
    Department of Biomedical Engineering, University of Wisconsin Madison, Madison, WI 53706, USA
    Acta Biomater 6:21-8. 2010
    ..Our study indicates that the modular peptides described here are multifunctional, and the characteristics of this approach suggest that it can potentially be applied to a range of biomaterials for regenerative medicine applications...
  88. ncbi Development of an osteoconductive PCL-PDIPF-hydroxyapatite composite scaffold for bone tissue engineering
    Juan Manuel Fernandez
    Grupo de Investigación en Osteopatías y Metabolismo Mineral, Departamento de Ciencias Biologicas, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, 1900 La Plata, Argentina
    J Tissue Eng Regen Med 5:e126-35. 2011
    ..The development of HAP-Blend composite, with improved physical, mechanical and osteoinductive properties, may potentially be used in bone tissue-engineering applications...
  89. ncbi Nanoscale hydroxyapatite particles for bone tissue engineering
    Hongjian Zhou
    Department of Nanomedical Engineering, College of Nanoscience and Nanotechnology, Pusan National University, Miryang 627 706, Republic of Korea
    Acta Biomater 7:2769-81. 2011
    ..This feature article looks afresh at nano-HAp particles, highlighting the importance of size, crystal morphology control, and composites with other inorganic particles for biomedical material development...
  90. ncbi Biologically inspired rosette nanotubes and nanocrystalline hydroxyapatite hydrogel nanocomposites as improved bone substitutes
    Lijie Zhang
    Division of Engineering, Brown University, Providence, RI 02912, USA
    Nanotechnology 20:175101. 2009
    ..In summary, the presently observed excellent properties of the biomimetic nanocrystalline HA/HRN hydrogel composites make them promising candidates for further study for bone tissue engineering applications...
  91. ncbi The effect of surface immobilized bisphosphonates on the fixation of hydroxyapatite-coated titanium implants in ovariectomized rats
    Ying Gao
    Department of Oral and Maxillofacial Surgery, Sichuan University, Chendgu, China
    Biomaterials 30:1790-6. 2009
    ..These results provide new evidence that immobilized BPs have positive effects on implant fixation in osteoporotic bone, in addition to their well-documented potency to inhibit implant loosening in normal bone...
  92. ncbi Influence of crystallite size of nanophased hydroxyapatite on fibronectin and osteonectin adsorption and on MC3T3-E1 osteoblast adhesion and morphology
    N Ribeiro
    INEB Instituto de Engenharia Biomedica, Divisão de Biomateriais, Universidade do Porto, Rua do Campo Alegre, 823, 4150 180 Porto, Portugal
    J Colloid Interface Sci 351:398-406. 2010
    ..Therefore the osteoblast adhesion and metabolic activity seemed to be more sensitive to surfaces morphology and roughness than to the type of adsorbed proteins...
  93. ncbi Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells
    Zhongli Shi
    Department of Orthopaedic Surgery, The Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009, China
    Acta Biomater 5:338-45. 2009
    ..Np20 has the best effect on promotion of cell growth and inhibition of cell apoptosis. This work provides an interesting view of the role of nano-HAPs as ideal biomedical materials in future clinical applications...
  94. pmc Chitosan composites for bone tissue engineering--an overview
    Jayachandran Venkatesan
    Department of Chemistry, Pukyong National University, Busan 608 737, Korea
    Mar Drugs 8:2252-66. 2010
    ..Herein, the preparation, mechanical properties, chemical interactions and in vitro activity of chitosan composites for bone tissue engineering will be discussed...
  95. ncbi Beneficial effects of hydroxyapatite on enamel subjected to 30% hydrogen peroxide
    Tao Jiang
    Key Laboratory for Oral Biomedical Engineering, Ministry of Education, School and Hospital of Stomatology, Wuhan University, 237 Luoyu Road, Wuhan 430079, PR China
    J Dent 36:907-14. 2008
    ..To evaluate the effect of combination of hydroxyapatite (HA) and hydrogen peroxide (HP) on color, microhardness and morphology of human tooth enamel...
  96. pmc The role of collagen in bone apatite formation in the presence of hydroxyapatite nucleation inhibitors
    Fabio Nudelman
    Laboratory of Materials and Interface Chemistry and Soft Matter CryoTEM Unit, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Nat Mater 9:1004-9. 2010
    ..We developed a model describing the mechanisms through which the structure, supramolecular assembly and charge distribution of collagen can control mineralization in the presence of inhibitors of hydroxyapatite nucleation...
  97. ncbi Outcome of acetabular revision using an uncemented hydroxyapatite-coated component: two- to five-year results and review
    Armugam Dorairajan
    Department of Trauma and Orthopaedic Surgery, University Hospitals, Coventry and Warwickshire NHS Trust, Coventry, UK
    J Arthroplasty 20:209-18. 2005
    ..Our early results favor the use of this type of cup in acetabular revisions with moderate bone loss, but longer-term follow-up will be required. Key words: acetabulum, hydroxyapatite, revision, bone deficiency, complications...
  98. ncbi BMP-2 plasmid loaded PLGA/HAp composite scaffolds for treatment of bone defects in nude mice
    Hemin Nie
    Department of Chemical and Biomolecular Engineering, National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore
    Biomaterials 30:892-901. 2009
    ..These observations demonstrate that the in vivo performance of these newly developed DNA delivery devices correlates well with their in vitro release profiles...
  99. ncbi Structural evolution of sol-gel-derived hydroxyapatite
    Dean Mo Liu
    Department of Metals and Materials Engineering, University of British Columbia, Vancouver, Canada
    Biomaterials 23:1679-87. 2002
    ..Through an appropriate heat treatment between 300 and 400d degrees C. the apatite prepared using current process exhibits a nano-scale, low-crystallinity, carbonated apatitic structure, which closely resembles that of human bone apatite...
  100. ncbi Porous scaffolds of polycaprolactone reinforced with in situ generated hydroxyapatite for bone tissue engineering
    Paola Fabbri
    Department of Materials and Environmental Engineering, University of Modena and Reggio Emilia, Modena, Italy
    J Mater Sci Mater Med 21:343-51. 2010
    ..The possibility to employ the developed composites as scaffolds for bone tissue regeneration was assessed by cytotoxicity test of the PCL/HA composites extracts and cell adhesion and proliferation in vitro studies...
  101. ncbi Nanostructured calcium phosphates for biomedical applications: novel synthesis and characterization
    Prashant N Kumta
    Department of Materials Science and Engineering, Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA 15213, USA
    Acta Biomater 1:65-83. 2005
    ..The resultant nanocrystalline phosphates have been characterized for their structure, morphology, thermal stability, and composition. Results of the in vitro transfection are also described...

Research Grants52

  1. CELL AND GENE THERAPY IN A MOUSE MODEL OF HUMAN OSTEOGEN
    Christopher Niyibizi; Fiscal Year: 2000
    ..abstract_text> ..
  2. Oral Immunology/Microbiology Annual Meeting
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  3. Oral Immunology/Microbiology Research Group Annual Mtg
    Daniel Fine; Fiscal Year: 2003
    ..Perpetuation of the OIMRG and its annual meetings greatly enhances the spirit of collegial interaction/collaboration among investigators with expertise in immunology and microbial pathogenesis as related to oral health and disease. ..
  4. PREVENTION OF DENTAL CARIES
    Shozo Takagi; Fiscal Year: 2005
    ....
  5. Microbial Markers for Periodontal Disease in Children
    Daniel Fine; Fiscal Year: 2005
    ....
  6. Attachment of Oral Actinobacillus to Epithelium
    Daniel Fine; Fiscal Year: 2008
    ..The longterm goal of this application is to use this information to identify targets for therapeutic agents that can interfere with attachment of Aa to oral tissues and thus prevent colonization leading to LAP. [unreadable] [unreadable]..
  7. Staining Techniques for Micro-CT Imaging of Microdamage
    RYAN ROEDER; Fiscal Year: 2004
    ..4. Image the three-dimensional damage developed in cortical bone specimens following low cycle fatigue in four point bending. Differences in damage patterns due to pure bending and combined bending and shear loading will be identified. ..
  8. Helical Rosette Nanotubes for Treating Osteoporotic Bone
    Thomas Webster; Fiscal Year: 2008
    ..abstract_text> ..
  9. OSTEOPOROSIS, COLLAGEN CROSS-LINKS & BIOMECHANICS
    Adele Boskey; Fiscal Year: 2003
    ..The proposed studies will be based on histology, FTIR Imaging (FTIRI), biomechanical, and biochemical techniques and represent a novel approach to evaluating the organic matrix inosteoporosis. ..
  10. IN VITRO INITIATION OF BIOLOGICAL CALCIFICATION
    Adele Boskey; Fiscal Year: 2009
    ....
  11. Micro-computed tomography system (Micro-CT)
    Adele Boskey; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  12. MECHANISM OF HARD TISSUE MINERALIZATION
    Adele L Boskey; Fiscal Year: 2010
    ..Aim 3: To determine whether DSPP and BGN interact synergistically during the collagen-based in vitro mineralization process using in vitro and in situ analyses. ..
  13. Novel Biomaterials Guiding Supercrestal Bone Growth
    Mei Wei; Fiscal Year: 2008
    ..This will also improve the reliability of the surgery and reduce the risk, pain and disruption associated with bone augmentation [unreadable] [unreadable] [unreadable]..
  14. Regulation of Cranial Suture Development by TGF-Beta and Fibroblast Growth Factor
    Arun Gosain; Fiscal Year: 2007
    ..This proposal will provide mechanistic insights into the regulation of cranial suture development, and help to relate mouse and human models of craniosynostosis. ..
  15. DENTIN BIOMINERALIZATION
    Charles Sfeir; Fiscal Year: 2007
    ..This data will also provide basic knowledge for designing treatment of ectopic mineralization specifically in diseases as such kidney stones or failing heart valve prosthesis. ..
  16. SALIVARY MUCOUS CELL GENE EXPRESSION
    DAVID CULP; Fiscal Year: 2007
    ..Moreover, expression of a novel human gene expressing a salivary apomucin will be verified, and if expressed, would be the focus of future studies to determine mechanisms regulating its expression. [unreadable] [unreadable]..
  17. Matrix Protein Regulation of Enamel Mineral Formation
    HENRY MARGOLIS; Fiscal Year: 2009
    ..Long term, such information should provide new insights for the development of bio-inspired materials and novel approaches for mineralized tissue repair and regeneration. ..
  18. Interstitial Cystitis Clinical Research Network (ICCRN)
    Robert Mayer; Fiscal Year: 2007
    ..abstract_text> ..
  19. Glucose-dependent Insulinotropic Peptide & Bone Turnover
    Carlos Isales; Fiscal Year: 2006
    ..This in turn may signal GIP as a potential hormone target for pharmacologic intervention in bone pathologies such as osteoporosis. [unreadable] [unreadable]..
  20. Pyrophosphate in vascular calcification of renal failure
    W CHARLES O apos NEILL; Fiscal Year: 2010
    ..The results will establish a new paradigm for vascular calcification in renal failure and form the basis for important clinical trials in humans. ..
  21. Development of a calcium-phosphate nanocomplex fluoride-based mouthrinse
    Robert Karlinsey; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  22. Formation of the Enamel-Dentin Interface
    Elia Beniash; Fiscal Year: 2010
    ..abstract_text> ..
  23. Multiaxial Single-Cell Biomechanics for Mechanotransduction
    SEAN KOHLES; Fiscal Year: 2007
    ..contribute to the understanding of pathologic cell states and therapeutic approaches for load-bearing tissues, and guide the design of engineered biomaterials which control cellular function [unreadable] [unreadable] [unreadable]..
  24. Oral Infectious Disease: Virulence and Host Determinants
    DAVID CULP; Fiscal Year: 2009
    ..Future studies can then focus on molecular mechanisms of host-pathogen interactions. Results may indicate important therapeutic targets to treat patients at high risk for caries (i.e., patients with xerostomia). ..
  25. RESIN-BASED REMINERALIZING CEMENTS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2009
    ..Completion of this research will lead to Ca- PO4 cements and composites with improved adhesion to dentin and improved strength for ART and the treatment of root caries. ..
  26. Rabbit Model for In Vivo Monitoring of Bone Structure
    Michael Voor; Fiscal Year: 2003
    ..It will give investigators the opportunity to watch the specific trabecular surfaces that are affected by various treatments and to observe when these effects occur. ..
  27. Bioactive signal gradients to engineer TMJ condyle osteochondral constructs
    MICHAEL DETAMORE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  28. Regulation and Control of Mineralization in Teeth
    HENRY MARGOLIS; Fiscal Year: 2007
    ..abstract_text> ..
  29. Imaging/Mapping Fourier Transform Infrared Microscope
    Andrei Stanishevsky; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  30. MOLECULAR REGULATION OF ENDOTHELIAL NA K 2CL COTRANSPORT
    W O NEILL; Fiscal Year: 2002
    ..abstract_text> ..
  31. BAG-75: UNIQUE MARKER OF PRIMARY BONE FORMATION
    JEFFREY GORSKI; Fiscal Year: 2003
    ..Stimulation of appositional formation by lamellar bone would not be expected to have the same effect. These future functional studies require determination of the BAG-75 cDNA sequence. ..
  32. REGULATION OF GLANDULAR MUCOUS CELL SECRETION
    DAVID CULP; Fiscal Year: 2001
    ..Results will provide specific information for determination of the dose and temporal administration of agonist in future clinical trials to treat patients with salivary hypofunction. ..
  33. CARIOGENIC POTENTIAL OF DENTAL PLAQUE FLUID
    HENRY MARGOLIS; Fiscal Year: 2001
    ..The long-term goal is to provide a unified picture of the caries process to be used in the design of improved delivery mechanisms for mineral ions, the assessment of caries risk, and the development of relevant in vitro models. ..
  34. Composition/Functional Elasticity of Engineered Tissues
    SEAN KOHLES; Fiscal Year: 2003
    ..The results will be used to predict the time-dependent performance of cell-polymer constructs, and to gain insight into the mechanisms of scaffold degradation and ECM synthesis...
  35. Renal Volume Measurement to Detect Early Kidney Disease
    W O NEILL; Fiscal Year: 2004
    ..abstract_text> ..
  36. Composition, Properties and structure of Tooth Enamel
    HENRY MARGOLIS; Fiscal Year: 2005
    ..Specific efforts are proposed to promote the inclusion of new, minority and female investigators, as well as persons with disabilities. ..
  37. Novel Nano Calcium Phosphate for Pulp Gene Delivery
    Charles Sfeir; Fiscal Year: 2005
    ....
  38. Extracrevicular Invasion by Periodontal Pathogens
    JOEL RUDNEY; Fiscal Year: 2005
    ..abstract_text> ..
  39. IN VIVO STUDIES OF SALIVA ANTIMICROBIAL PROTEINS
    JOEL RUDNEY; Fiscal Year: 2001
    ..By focusing on redundancy and complexing, this project also addresses the question of whether individual proteins exert unique and specific effects in the mouth. ..
  40. Sensate Scaffolds for Orthopaedic Tissue Repair
    John Szivek; Fiscal Year: 2005
    ..A system of this type will provide a means of monitoring healing and rehabilitation in patients. ..
  41. TMJ Bioengineering Conference
    MICHAEL DETAMORE; Fiscal Year: 2006
    ..abstract_text> ..
  42. Laser Ablation of Dental Hard Tissues
    Daniel Fried; Fiscal Year: 2006
    ..Use of those laser systems is likely to lead to the practice of more conservative Dental procedures that will markedly reduce the amount of healthy tissue loss that is generally associated with conventional cavity preparations. ..
  43. IMPROVED PREVENTIVE/RESTORATIVE RESINS AND COMPOSITES
    SABINE DICKENS; Fiscal Year: 2006
    ..The data gathered in these experiments will serve to support a larger R01 grant application with the long-term objectives of developing improved durable materials for adhesives and adhesive composites. [unreadable] [unreadable]..
  44. Estrogen: Chrodroprotective or Destructive?
    Sally Frenkel; Fiscal Year: 2002
    ..The inconclusive and contradictory data from human and animal studies render the proposed studies highly significant. ..
  45. EPITOPE DISCOVERY--NEW ROUTE TO VACCINES
    George Smith; Fiscal Year: 2002
    ..abstract_text> ..
  46. MINERALIZATION OF PRIMARY BONE
    JEFFREY GORSKI; Fiscal Year: 2008
    ..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
  47. Risk for Renal Injury Caused by Shock Wave Lithotripsy
    Andrew Evan; Fiscal Year: 2008
    ..All of these proposed studies aim at understanding the adverse effects of shock waves and advancing the safety of all stone patients at a time when reports of adverse effects in SWL are on the rise. ..
  48. IKSI: 1st Annual International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  49. IKSI: 2nd International Urolithiasis Research Symposium
    Andrew Evan; Fiscal Year: 2008
    ..This assumption was supported by the great success of the 1st International Urolithiasis Research symposium and the high level of interest in the 2nd symposium date. [unreadable] [unreadable] [unreadable]..
  50. TEM with Digital and Cryopreparation Systems
    Andrew Evan; Fiscal Year: 2003
    ..Dr. Richard Gregory will employ immunohistochemistry to examine the role of a Streptococcus mutans 65 kDa fimbrial protein binding as a mechanism for the induction of dental carries. ..
  51. ESTROGEN STATUS AND THE FUNCTION OF CORONARY ARTERIES
    VIRGINIA MILLER; Fiscal Year: 2002
    ..The experiments of this proposal take such an approach using molecular to integrated whole animal physiology. ..