- Metals, oxidative stress and neurodegenerative disorders
Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, SK 949 74, Nitra, Slovakia
Mol Cell Biochem 345:91-104. 2010
..The aim of this review is to discuss the role of redox metals Fe and Cu and non-redox metal zinc (Zn) in oxidative stress-related etiology of AD and PD...
- Nutritional immunity: transition metals at the pathogen-host interface
M Indriati Hood
Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, A5102 MCN, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
Nat Rev Microbiol 10:525-37. 2012
Transition metals occupy an essential niche in biological systems. Their electrostatic properties stabilize substrates or reaction intermediates in the active sites of enzymes, and their heightened reactivity is harnessed for catalysis...
- Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
J Am Coll Cardiol 48:193-202. 2006
..This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST)...
- Metalloproteins and metal sensing
Kevin J Waldron
Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK
Nature 460:823-30. 2009
..Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.
- Metal ions in biological catalysis: from enzyme databases to general principles
Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
J Biol Inorg Chem 13:1205-18. 2008
..We used Metal-MACiE to assess the functions performed by metals in biological catalysis and the relative frequencies of different metals in different roles, which can be related ..
- Transition metal speciation in the cell: insights from the chemistry of metal ion receptors
Lydia A Finney
Department of Chemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Il 60208 3113, USA
Science 300:931-6. 2003
..The different coordination numbers, types of coordinating residues, and solvent accessibilities of these sites are providing insight into the inorganic chemistry of the cytoplasm...
- Self-assembled monolayers of thiolates on metals as a form of nanotechnology
J Christopher Love
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
Chem Rev 105:1103-69. 2005
- Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
Jean Marc Moulis
Laboratoire de Chimie et Biologie des Metaux, CEA Grenoble, DSV, iRTSV, 17 rue des Martyrs, Grenoble Cedex 9, France
Biometals 23:877-96. 2010
..biologically relevant cadmium concentrations on different cell types, improved knowledge of the homeostasis of essential metals, and use of these data in a theoretical framework integrating all cellular aspects of cadmium effects.
- Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
Nature 391:251-8. 1998
..The structure illustrates how nucleotides are selected in a template-directed manner, and provides a structural basis for a metal-assisted mechanism of phosphoryl transfer by a large group of related polymerases...
- Ultrasmooth patterned metals for plasmonics and metamaterials
Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
Science 325:594-7. 2009
..in real plasmonic devices, simple high-throughput methods are needed to fabricate high-quality patterned metals. We combined template stripping with precisely patterned silicon substrates to obtain ultrasmooth pure metal films ..
- How do bacterial cells ensure that metalloproteins get the correct metal?
Kevin J Waldron
Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, UK
Nat Rev Microbiol 7:25-35. 2009
..richly varied and exquisitely attuned to their inorganic partners, yet many metalloproteins still select the wrong metals when presented with mixtures of elements...
- Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR
Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205Tech Drive, Evanston, IL 60208, USA
Science 301:1383-7. 2003
..This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch...
- Metals in neurobiology: probing their chemistry and biology with molecular imaging
Emily L Que
Department of Chemistry, University of California, Berkeley, California 94720, USA
Chem Rev 108:1517-49. 2008
- How Saccharomyces cerevisiae copes with toxic metals and metalloids
Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland
FEMS Microbiol Rev 34:925-51. 2010
Toxic metals and metalloids are widespread in nature and can locally reach fairly high concentrations. To ensure cellular protection and survival in such environments, all organisms possess systems to evade toxicity and acquire tolerance...
- Molecular and ionic mimicry and the transport of toxic metals
Christy C Bridges
Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
Toxicol Appl Pharmacol 204:274-308. 2005
..Surprisingly, little is understood about the mechanisms by which certain metals and metal-containing species gain entry into target cells...
- Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine
Prashant K Jain
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
Acc Chem Res 41:1578-86. 2008
- Nucleases: diversity of structure, function and mechanism
Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 5, Rm B1 03, Bethesda, MD 20892, USA
Q Rev Biophys 44:1-93. 2011
..I also find several previously unnoted relationships between different nucleases and shared catalytic configurations...
- Functional specialization within the Fur family of metalloregulators
Jin Won Lee
Department of Microbiology, Cornell University, Wing Hall, Ithaca, NY 14853 8101, USA
Biometals 20:485-99. 2007
..Despite numerous studies, the mechanism of metal ion sensing by Fur family proteins is still controversial. Other family members use metal catalyzed oxidation reactions to sense peroxide-stress (PerR) or the availability of heme (Irr)...
- Metals, minerals and microbes: geomicrobiology and bioremediation
Geoffrey Michael Gadd
Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
Microbiology 156:609-43. 2010
..actively to geological phenomena, and central to many such geomicrobial processes are transformations of metals and minerals...
- Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces
The Immune Disease Institute and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Mol Cell 32:849-61. 2008
..This mechanism propagates allostery over long distances and couples cytoskeleton attachment of integrins to their high-affinity state...
- A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up
Research Institute of Military Medicine, Helsinki, Finland
BMC Musculoskelet Disord 11:78. 2010
..We analyzed the causes of total and site-specific mortality among a cohort of patients with MM and with metal-on-polyethylene (MP) THA after a long follow-up time...
- Pseudotumours associated with metal-on-metal hip resurfacings
Nuffield Orthopaedic Centre, Oxford, England
J Bone Joint Surg Br 90:847-51. 2008
..We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause...
- Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo
Thomas J Webster
Department of Biomedical Engineering, Purdue University, 1296Patter Building, West Lafayette, IN 47905, USA
Biomaterials 25:4731-9. 2004
..However, to date, interactions of osteoblasts on nanophase compared to conventional metals remain to be elucidated...
- Some precautions in using chelators to buffer metals in biological solutions
Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
Cell Calcium 35:427-31. 2004
..This communication discusses common misunderstandings and pitfalls in use of these buffers and provides information on choosing the best metal buffer for different experimental situations...
- Microbial metalloproteomes are largely uncharacterized
Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
Nature 466:779-82. 2010
..We present here a robust, metal-based approach to determine all metals an organism assimilates and identify its metalloproteins on a genome-wide scale...
- Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives
Faculty of Engineering, Department of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada
Nanoscale 3:335-53. 2011
..and biological processes at the implant/tissue interface is fostering a new trend in designing implantable metals. Cutting-edge expertise and techniques drawn from widely separated fields, such as nanotechnology, materials ..
- Metal-on-metal bearings: the evidence so far
F S Haddad
Department of Orthopaedics, University College Hospital, 235 Euston Road, London NW1 2BU, UK
J Bone Joint Surg Br 93:572-9. 2011
..This review examines the literature and contemporary presentations on current clinical dilemmas in metal-on-metal hip replacement...
- Antimicrobial activity of metals: mechanisms, molecular targets and applications
Joseph A Lemire
Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada
Nat Rev Microbiol 11:371-84. 2013
b>Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear...
- Patterns of levels of biological metals in CSF differ among neurodegenerative diseases
Department of Neurology and Geriatrics, Gifu University, Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
J Neurol Sci 303:95-9. 2011
We measured the levels of some biological metals: copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), and zinc (Zn) in the cerebrospinal fluid (CSF) in patients with neurodegenerative diseases (52 patients with amyotrophic lateral ..
- Hydrogen, metals, bifurcating electrons, and proton gradients: the early evolution of biological energy conservation
William F Martin
Institute of Molecular Evolution, University of Dusseldorf, 40225 Dusseldorf, Germany
FEBS Lett 586:485-93. 2012
..Electron bifurcation likely figures into the early evolution of biological energy conservation...
- Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals
Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121
J Biol Chem 269:1001-9. 1994
..Heavy metals activate HO-1 gene transcription and the rat gene contains a putative metal regulatory element (Müller, R. M...
- Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray microspectroscopy
Cellular Chemical Imaging and Speciation Group, CNAB, CNRS UMR 5084, University of Bordeaux, 33175 Gradignan, France
J R Soc Interface 6:S649-58. 2009
The direct detection of biologically relevant metals in single cells and of their speciation is a challenging task that requires sophisticated analytical developments...
- Untangling amyloid-β, tau, and metals in Alzheimer's disease
Masha G Savelieff
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
ACS Chem Biol 8:856-65. 2013
..Herein, we present current understanding on the roles of Aβ, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis...
- Risk of cancer with metal-on-metal hip replacements: population based study
Keijo T Mäkelä
Department of Orthopaedics and Traumatology, Surgical Hospital, Turku University Hospital, FI 20701 Turku, Finland
BMJ 345:e4646. 2012
..To assess the risk of cancer associated with modern primary metal-on-metal hip replacements...
- Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statistics
Alison J Smith
Musculosketal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Bristol BS10 5NB, UK
BMJ 344:e2383. 2012
- Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants
Leibniz Institut für Pflanzenbiochemie, Weinberg 3, 06120 Halle Saale, Germany
Biochimie 88:1707-19. 2006
Over the past 200 years emissions of toxic heavy metals have risen tremendously and significantly exceed those from natural sources for practically all metals...
- Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear
D J Langton
North Tees and Hartlepool NHS Trust, Stockton on Tees and Centre for Rehabilitation, Newcastle University, Newcastle upon Tyne, England
J Bone Joint Surg Br 92:38-46. 2010
..Surgeons must consider implant design, expected component size and acetabular component positioning in order to reduce early failures when performing large-bearing metal-on-metal hip resurfacing and replacement...
- Deformation-mechanism map for nanocrystalline metals by molecular-dynamics simulation
Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
Nat Mater 3:43-7. 2004
..c.c. metals. This transition in the deformation mechanism results in a maximum yield strength at a grain size (the 'strongest ..
- Nationwide study of cancer risk among hip replacement patients in Sweden
L B Signorello
International Epidemiology Institute, Rockville, MD 20850, USA
J Natl Cancer Inst 93:1405-10. 2001
- Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals
J T Minang
Department of Immunology, Stockholm University, Stockholm, Sweden
Clin Exp Immunol 146:417-26. 2006
Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects...
- Metal oxide gas sensors: sensitivity and influencing factors
Key Laboratory for Liquid Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan, 250061, China
Sensors (Basel) 10:2088-106. 2010
..In this brief review, attention will be focused on changes of sensitivity of conductometric semiconducting metal oxide gas sensors due to the five factors mentioned above...
- Microbes and metals: interactions in the environment
Institute of Microbiology, Friedrich Schiller University, Jena, Germany
J Basic Microbiol 47:453-67. 2007
..The strongly interdisciplinary field of bio-geo-interactions spanning from the microorganism to the mineral holds much promise for future developments in both basic research as well as applied sciences...
- Cancer risk is not increased after conventional hip arthroplasty
Research Department, Centre for Military Medicine, Finland
Acta Orthop 81:77-81. 2010
..A long latent period is required for solid tumors. We therefore re-analyzed a large THA cohort for cancer...
- Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers
Markus A Wimmer
Department of Orthopedic Surgery, Rush University Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
J Orthop Res 28:436-43. 2010
..This novel finding of a mechanically mixed zone of nanocrystalline metal and organic constituents provides the basis for understanding particle release and may help in identifying new strategies to reduce MoM wear...
- Metals and apoptosis: recent developments
Suresh Vir Singh Rana
Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut, India
J Trace Elem Med Biol 22:262-84. 2008
..A variety of toxins can induce apoptosis. Carcinogenic transition metals, viz...
- Dietary exposure to metals and other elements in the 2006 UK Total Diet Study and some trends over the last 30 years
The Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, UK
Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1380-404. 2010
Concentrations of 24 elements including metals in the 2006 UK Total Diet Study (TDS) were measured and dietary exposures estimated. Composite samples for the 20 TDS food groups (bread, fish, fruit, etc...
- Melanin as a target for melanoma chemotherapy: pro-oxidant effect of oxygen and metals on melanoma viability
Patrick J Farmer
Department of Chemistry, University of California, Irvine, CA 92697 2025, USA
Pigment Cell Res 16:273-9. 2003
..The antimelanoma effect of metal- and oxygen-induced stress appears additive rather than synergistic; both treatments are shown to be significantly less toxic to melanocytes...
- Metals affect soil bacterial and fungal functional diversity differently
Anna M Stefanowicz
Institute of Environmental Sciences, Jagiellonian University, Krakow, Poland
Environ Toxicol Chem 27:591-8. 2008
Heavy metals can cause a decrease in the taxonomic diversity of soil communities...
- SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans
Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
PLoS ONE 4:e7792. 2009
..smf-1 and smf-3 but not in smf-2 mutants, increased Mn exposure led to decreased Fe levels, suggesting that both metals compete for transport by SMF-2...
- Fabrication methods of porous metals for use in orthopaedic applications
National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
Biomaterials 27:2651-70. 2006
..Depending on the porosity, moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the problems associated with stress shielding...
- The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation
Jin Won Lee
Department of Microbiology, Cornell University, Ithaca, New York 14853, USA
Nature 440:363-7. 2006
- New developments in the understanding of the cation diffusion facilitator family
Christopher J Haney
Department of Soil, Water, and Environmental Science, University of Arizona, Shantz Bld number 38 Rm 424, Tucson, AZ 85721, USA
J Ind Microbiol Biotechnol 32:215-26. 2005
..This review seeks to give an overview of the data prompting these conclusions, while presenting additional data whose interpretation is still contentious...
- Metals in cigarette smoke
Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Innsbruck Medical University, Austria
IUBMB Life 57:805-9. 2005
b>Metals are vital for a huge number of physiological processes in the human body, but can also destroy health when the concentration is not within the physiologically favourable range...
- Expression of the IRT1 metal transporter is controlled by metals at the levels of transcript and protein accumulation
Erin L Connolly
Department of Biological Sciences, Gilman 6044, Dartmouth College, Hanover, NH 03755, USA
Plant Cell 14:1347-57. 2002
..levels of cadmium and zinc than wild-type plants, indicating that IRT1 is responsible for the uptake of these metals and that IRT1 protein levels are indeed increased in these plants...
- Some interesting properties of metals confined in time and nanometer space of different shapes
M A El-Sayed
Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
Acc Chem Res 34:257-64. 2001
- Selenium and 17 other largely essential and toxic metals in muscle and organ meats of Red Deer (Cervus elaphus)--consequences to human health
Research Group of Environmental Chemistry, Ecotoxicology and Food Toxicology, Institute of Environmental Sciences and Public Health, University of Gdansk, Poland
Environ Int 37:882-8. 2011
..and deficit to Deer as well as the benefits and risk to humans associated with the essential and toxic metals intake resulting from consumption of Deer meat and products...
- Complexation between Hg(II) and biofilm extracellular polymeric substances: an application of fluorescence spectroscopy
State Key Laboratory of Enviromental Geochemistry, Institute of Geochemistry Chinese Academy of Sciences, Guiyang, 550002, China
J Hazard Mater 175:359-65. 2010
..suggest that EPS from biofilm is a class of important organic ligands for complexation with Hg(II) and may significantly affect the chemical forms, mobility, bioavailability and ecotoxicity of heavy metals in the aquatic environment.
- Cytotoxicity of dental alloys, metals, and ceramics assessed by millipore filter, agar overlay, and MTT tests
NIOM Scandinavian Institute of Dental Materials, Haslum, Norway
J Prosthet Dent 84:229-36. 2000
..Biocompatibility of dental materials is dependent on the release of elements from the materials. In addition, the composition, pretreatment, and handling of the materials influence the element release...
- Novel regulation targets of the metal-response BasS-BasR two-component system of Escherichia coli
Department of Frontier Bioscience, Hosei University, Koganei, Tokyo, Japan
Microbiology 158:1482-92. 2012
- Type II restriction endonucleases: structure and mechanism
Institut fur Biochemie, Justus Liebig Universitat, Heinrich Buff Ring 58, 35392, Giessen, Germany
Cell Mol Life Sci 62:685-707. 2005
..A major emphasis of this review will be on target site location and the mechanism of catalysis, two problems currently being addressed in the literature...
- Metal ion homeostasis in Bacillus subtilis
Charles M Moore
Department of Microbiology, Cornell University, Ithaca, New York 14853 8101, USA
Curr Opin Microbiol 8:188-95. 2005
..A Fur homolog, PerR, functions as an Fe(II)-dependent peroxide stress sensor and regulates putative metal transport and storage functions...
- The biogeochemical cycles of trace metals in the oceans
F M M Morel
Department of Geosciences, Princeton University, Princeton, NJ 08544, USA
Science 300:944-7. 2003
Planktonic uptake of some essential metals results in extraordinarily low concentrations in surface seawater...
- Trace metal imbalance associated with oxidative stress and inflammatory status in anti-hepatitis C virus antibody positive subjects
Chih Hung Guo
Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC
Environ Toxicol Pharmacol 33:288-96. 2012
Toxic and essential trace metals, oxidative stress, and inflammatory status were evaluated in anti-hepatitis C virus (HCV) antibody-positive subjects...
- Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases
Ebany J Martinez-Finley
Division of Clinical Pharmacology and Pediatric Toxicology, Vanderbilt University Medical Center, 11425 MRB IV, 2215 B Garland Ave, Nashville, TN 37232 0414, USA
Metallomics 3:271-9. 2011
..b>Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms...
- Metals and women's health
Institute of Environmental Medicine, Karolinska Institutet, Sweden
Environ Res 88:145-55. 2002
..Obviously, gender-related differences in exposure and health effects caused by metals are highly neglected research areas, which need considerable focus in the future.
- Corrosion at the cone/taper interface leads to failure of large-diameter metal-on-metal total hip arthroplasties
Department of Orthopaedics, Otto von Guericke University, Leipziger Str 44, 39108 Magdeburg, Germany
Clin Orthop Relat Res 470:3101-8. 2012
..Metal-on-metal (MoM) THAs have reduced wear rates compared with metal-on-polyethylene. However, elevated serum metal ion levels and pseudotumors have been reported in large MoM articulations...
- Metallurgical recovery of metals from electronic waste: a review
Department of Materials Science and Engineering, Norwegian University of Science and Technology NTNU, Alfred Getz vei 2, N 7491 Trondheim, Norway
J Hazard Mater 158:228-56. 2008
..It is showed that the major economic driver for recycling of electronic waste is from the recovery of precious metals. The state of the art in recovery of precious metals from electronic waste by pyrometallurgical processing, ..
- Distribution, correlation and risk assessment of selected metals in urban soils from Islamabad, Pakistan
Department of Chemistry, Quaid i Azam University, Islamabad 45320, Pakistan
J Hazard Mater 192:887-98. 2011
..Multivariate statistical approach was used to study the apportionment of selected metals in the soil samples during summer and winter...
- Metal allergy--a review on exposures, penetration, genetics, prevalence, and clinical implications
Jacob P Thyssen
National Allergy Research Centre and Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
Chem Res Toxicol 23:309-18. 2010
..remains present and should always be taken into consideration when one interprets allergic patch test reactions to metals. Traditionally, nickel, cobalt, and chromium have been the most important contact allergens...
- Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence
Bogdan F Gh Popescu
Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan SK Canada
Phys Med Biol 54:651-63. 2009
Rapid-scanning x-ray fluorescence (RS-XRF) is a synchrotron technology that maps multiple metals in tissues by employing unique hardware and software to increase scanning speed...
- Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats
James M Antonini
Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
Arch Toxicol 85:487-98. 2011
..The objectives of this study were to compare the persistence of deposited metals and the inflammatory potential of stainless and mild steel welding fumes, the two most common fumes used in US ..
- The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents
School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
Biomaterials 31:8332-40. 2010
..We have demonstrated a coating for metal alloys with multifaceted biocompatibility that resists delamination and is non-thrombogenic, with implications for improving coronary stent efficacy...
- Exposure assessment of persistent organic pollutants and metals in Mexican children
Departamento de Toxicologia Ambiental, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Avenida Venustiano Carranza 2405, 78210 San Luis Potosi, S L P, Mexico
Chemosphere 74:974-80. 2009
..Mexico have contributed to the reduction in the production or use of some persistent organic pollutants (POPs) and metals. However, monitoring of POPs concentrations in humans living in hot spots is lacking...
- New roles for bacterial siderophores in metal transport and tolerance
Isabelle J Schalk
UMR7242, University of Strasbourg CNRS, ESBS, Blvd Sebastien Brant, F 67413 Illkirch, Strasbourg, France
Environ Microbiol 13:2844-54. 2011
..Despite their preference for iron, they can also chelate numerous other metals with variable affinities...
- Retrieval analysis of 240 metal-on-metal hip components, comparing modular total hip replacement with hip resurfacing
Department of Musculoskeletal Surgery, Imperial College London, London, United Kingdom
J Bone Joint Surg Br 93:307-14. 2011
..These findings show that failed metal-on-metal hip resurfacing and modular THRs have similar component wear rates and are both associated with raised pre-revision blood levels of metal ions...
- Long-term environmental monitoring of persistent organic pollutants and metals in a chemical/petrochemical area: human health risks
Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenc 21, 43201 Reus, Catalonia, Spain
Environ Pollut 159:1769-77. 2011
..biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polycyclic aromatic hydrocarbons (PAHs), as well as some metals are periodically monitored in soil and vegetation samples collected in Tarragona County (Spain)...
- Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins
King s College London, Diabetes and Nutritional Sciences Division, London, UK
Biometals 24:411-8. 2011
..These new findings establish critically important functions of zinc ions and zinc metalloproteins in cellular control...
- Essential metals for nitrogen fixation in a free-living N₂-fixing bacterium: chelation, homeostasis and high use efficiency
J P Bellenger
Department of Geosciences, PEI, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
Environ Microbiol 13:1395-411. 2011
..In the growth medium of A. vinelandii, metals are bound to strong complexing agents (metallophores) excreted by the bacterium...
- Covered metal stents for the treatment of biliary complications after orthotopic liver transplantation
Gastroenterology Service, Liver Transplantation Unit, Rio Hortega Hospital, Valladolid, Spain
Transplant Proc 42:2966-9. 2010
..Covered self-expandable metal stents (CSEMSs) may be an alternative to the current endoscopic standard treatment with periodic plastic stent replacement...
- Direct writing of flexible electronics through room temperature liquid metal ink
Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
PLoS ONE 7:e45485. 2012
- Cementless Metasul metal-on-metal total hip arthroplasties at 13 years
Divisione Ortopedia II, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Milan, Italy
J Arthroplasty 27:186-92. 2012
..Metal wear-related aseptic loosening was not the major reason for failure in our Metasul metal-on-metal THAs. Recurrent dislocation was the main reason for revision in our series...
- Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm?
Department II of Orthopaedics and Traumatology, Bologna University, Rizzoli Orthopaedic Institute, Via G C Pupilli 1, 40136 Bologna, Italy
Clin Orthop Relat Res 469:180-7. 2011
..Metal-on-metal Birmingham hip resurfacing (MOM-BHR) is an alternative to metal-on-metal total hip arthroplasty (MOM-THA), especially for young and/or active patients. However, wear resulting in increased serum ion levels is a concern...
- Surgical variables influence metal ion levels after hip resurfacing
Nicholas M Desy
Division of Orthopaedic Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, QC, Canada
Clin Orthop Relat Res 469:1635-41. 2011
..However, there exists some controversy regarding the effect of different surgical variables on the concentration of metal ions in whole blood of patients after hip resurfacing...
- The challenges of determining metal-protein affinities
University of Melbourne, Parkville, Victoria, Australia
Nat Prod Rep 27:768-89. 2010
..On the other hand, transport proteins responsible for 'chaperoning' essential metals to their cellular destinations appear to bind the metal ions selectively (KD < 10(-7) M, both for speciation ..
- Crystal structure of the beta beta alpha-Me type II restriction endonuclease Hpy99I with target DNA
International Institute of Molecular and Cell Biology, Trojdena 4, 02 109 Warsaw, Poland
Nucleic Acids Res 37:3799-810. 2009
..g. I-PpoI) and Holliday junction resolvases (e.g. T4 endonuclease VII)...
- Histological features of pseudotumor-like tissues from metal-on-metal hips
J Vernon Luck Sr MD Orthopaedic Research Center, Orthopaedic Hospital UCLA, 2400 S Flower Street, Los Angeles, CA 90007, USA
Clin Orthop Relat Res 468:2321-7. 2010
..The tissue features may help distinguish reactions to high wear from those with suspected metal hypersensitivity...
- Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics
James A Duce
The Mental Health Research Institute, Parkville, Victoria 3052, Australia
Prog Neurobiol 92:1-18. 2010
..of metal ions is critical for many physiological functions, particularly in the central nervous system, where metals are essential for development and maintenance of enzymatic activities, mitochondrial function, myelination, ..
- A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction
Jennifer J Telford
St Paul s Hospital, Vancouver, British Columbia, Canada
Gastrointest Endosc 72:907-14. 2010
..The most common complication of uncovered biliary self-expandable metal stents (SEMSs) is tumor ingrowth. The addition of an impenetrable covering may prolong stent patency...
- Modeling of metal interaction geometries for protein-ligand docking
University of Hamburg, Center for Bioinformatics, Bundesstrasse 43, 20146 Hamburg, Germany
Proteins 71:1237-54. 2008
..Secondly, the new metal interaction model was tested in terms of predicting protein-ligand complexes. In the majority of test cases, the new interaction model resulted in an improved docking accuracy of the top ranking placements...
- Boon and bane of metal ions in medicine
Katherine H Thompson
Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
Science 300:936-9. 2003
..One of the challenges of designing metal-based drugs is to balance the potential toxicity of an active formulation with the substantial positive impact of these increasingly common therapeutic and diagnostic aids...
- Efficacy and safety of fully covered self-expandable metallic stents in biliary complications after liver transplantation: a preliminary study
Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center, Palermo, Italy
Liver Transpl 15:1493-8. 2009
..A cost analysis should be performed in order to evaluate whether to treat transplanted patients suffering from biliary complications with covered self-expandable metallic stent placement as first-line therapy...
- Utility of removable esophageal covered self-expanding metal stents for leak and fistula management
Shanda H Blackmon
Department of Surgery, The Methodist Hospital, Houston, Texas 77030, USA
Ann Thorac Surg 89:931-6; discussion 936-7. 2010
..The primary objective of this study was to determine the efficacy and safety of covered self-expanding metal stents when used to treat complicated leaks and fistulas...
- Blood and urine metal ion levels in young and active patients after Birmingham hip resurfacing arthroplasty: four-year results of a prospective longitudinal study
The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
J Bone Joint Surg Br 89:169-73. 2007
..The levels in this study provide a baseline against which the in vivo wear performance of newer bearings can be compared...
- Controlling ribozyme activity by metal ions
Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
Curr Opin Chem Biol 14:269-75. 2010
..Comparison of the observed cleavage rates of hammerhead ribozymes with the metal ion affinities of different ligands reveals that these rates correlate perfectly with the intrinsic phosphate affinities of the metal ions involved...
- Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicity
Ming Hon Hou
Institute of Biological Chemistry, Academia Sinica Taipei, 115 Taiwan
Nucleic Acids Res 33:1352-61. 2005
..Evidences obtained in this study suggest that the biological effects caused by the [(Mith)2-Fe(II)] complex may be further explored in the future...
- DMT1: a mammalian transporter for multiple metals
Michael D Garrick
Department of Biochemistry, SUNY at Buffalo, Buffalo, NY 14214, USA
Biometals 16:41-54. 2003
DMT1 has four names, transports as many as eight metals, may have four or more isoforms and carries out its transport for multiple purposes. This review is a start at sorting out these multiplicities...
- Bioaccumulation of metals and effects of a landfill in small mammals Part III: Structural alterations
Servei de Microscopia, Facultat de Ciencies, Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
Environ Res 109:960-7. 2009
..Garraf landfill located in a protected site (NE Spain) contain several potentially toxic substances such as heavy metals. Here we report the histopathological alterations produced by this pollution in wild specimens of an omnivorous ..
- In-air micro-particle induced X-ray emission analysis of asbestos and metals in lung tissue
Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
Int J Immunopathol Pharmacol 21:567-76. 2008
..emission (in-air micro-PIXE) system for assessment of the spatial distribution and content of asbestos and other metals in lung tissue...
- Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter
Ad M Knaapen
Particle Research Core, Research Institute for Environmental Health IUF, Dusseldorf, Germany
Mol Cell Biochem 234:317-26. 2002
..OH formation, implicating an important role of H2O2. Moreover, our data indicate that direct 'particle' effects contribute to the genotoxic hazard of ambient particulate matter in lung target cells...
- Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity
M F Frasco
IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
Biomarkers 10:360-75. 2005
..activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
- Prediction of 3D metal binding sites from translated gene sequences based on remote-homology templates
Department of Plant Sciences, Weizmann Institute of Science, Rehovot, Israel
Proteins 76:365-74. 2009
..A web server for prediction of metal binding sites from protein sequence is provided...