Summary: Electropositive chemical elements characterized by ductility, malleability, luster, and conductance of heat and electricity. They can replace the hydrogen of an acid and form bases with hydroxyl radicals. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. ncbi Metals, oxidative stress and neurodegenerative disorders
    Klaudia Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, SK 949 74, Nitra, Slovakia
    Mol Cell Biochem 345:91-104. 2010
  2. pmc Nutritional immunity: transition metals at the pathogen-host interface
    M Indriati Hood
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, A5102 MCN, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Rev Microbiol 10:525-37. 2012
  3. ncbi Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
    Michael Joner
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 48:193-202. 2006
  4. ncbi Metalloproteins and metal sensing
    Kevin J Waldron
    Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK
    Nature 460:823-30. 2009
  5. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
  6. ncbi Transition metal speciation in the cell: insights from the chemistry of metal ion receptors
    Lydia A Finney
    Department of Chemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Il 60208 3113, USA
    Science 300:931-6. 2003
  7. ncbi Self-assembled monolayers of thiolates on metals as a form of nanotechnology
    J Christopher Love
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1103-69. 2005
  8. ncbi Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
    Jean Marc Moulis
    Laboratoire de Chimie et Biologie des Metaux, CEA Grenoble, DSV, iRTSV, 17 rue des Martyrs, Grenoble Cedex 9, France
    Biometals 23:877-96. 2010
  9. ncbi Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:251-8. 1998
  10. ncbi Ultrasmooth patterned metals for plasmonics and metamaterials
    Prashant Nagpal
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
    Science 325:594-7. 2009

Detail Information

Publications375 found, 100 shown here

  1. ncbi Metals, oxidative stress and neurodegenerative disorders
    Klaudia Jomova
    Department of Chemistry, Faculty of Natural Sciences, Constantine the Philosopher University, SK 949 74, Nitra, Slovakia
    Mol Cell Biochem 345:91-104. 2010
    ..The aim of this review is to discuss the role of redox metals Fe and Cu and non-redox metal zinc (Zn) in oxidative stress-related etiology of AD and PD...
  2. pmc Nutritional immunity: transition metals at the pathogen-host interface
    M Indriati Hood
    Department of Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, A5102 MCN, 1161 21st Avenue South, Nashville, Tennessee 37232, USA
    Nat Rev Microbiol 10:525-37. 2012
    Transition metals occupy an essential niche in biological systems. Their electrostatic properties stabilize substrates or reaction intermediates in the active sites of enzymes, and their heightened reactivity is harnessed for catalysis...
  3. ncbi Pathology of drug-eluting stents in humans: delayed healing and late thrombotic risk
    Michael Joner
    CVPath, International Registry of Pathology, Gaithersburg, Maryland 20878, USA
    J Am Coll Cardiol 48:193-202. 2006
    ..This study examined human drug-eluting stents (DES) to determine the long-term effects of these stents on coronary arterial healing and identified mechanisms underlying late stent thrombosis (LST)...
  4. ncbi Metalloproteins and metal sensing
    Kevin J Waldron
    Cell and Molecular Biosciences, Medical School, Newcastle University, Newcastle NE2 4HH, UK
    Nature 460:823-30. 2009
    ..Such homeostasis needs metal sensors, and there is an ongoing search to discover the metal-sensing mechanisms. For metalloproteins to acquire the right metals, metal sensors must correctly distinguish between the inorganic elements.
  5. ncbi Metal ions in biological catalysis: from enzyme databases to general principles
    Claudia Andreini
    Magnetic Resonance Center CERM, University of Florence, Via L Sacconi 6, 50019, Sesto Fiorentino, Italy
    J Biol Inorg Chem 13:1205-18. 2008
    ..We used Metal-MACiE to assess the functions performed by metals in biological catalysis and the relative frequencies of different metals in different roles, which can be related ..
  6. ncbi Transition metal speciation in the cell: insights from the chemistry of metal ion receptors
    Lydia A Finney
    Department of Chemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Il 60208 3113, USA
    Science 300:931-6. 2003
    ..The different coordination numbers, types of coordinating residues, and solvent accessibilities of these sites are providing insight into the inorganic chemistry of the cytoplasm...
  7. ncbi Self-assembled monolayers of thiolates on metals as a form of nanotechnology
    J Christopher Love
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    Chem Rev 105:1103-69. 2005
  8. ncbi Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
    Jean Marc Moulis
    Laboratoire de Chimie et Biologie des Metaux, CEA Grenoble, DSV, iRTSV, 17 rue des Martyrs, Grenoble Cedex 9, France
    Biometals 23:877-96. 2010
    ..biologically relevant cadmium concentrations on different cell types, improved knowledge of the homeostasis of essential metals, and use of these data in a theoretical framework integrating all cellular aspects of cadmium effects.
  9. ncbi Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nature 391:251-8. 1998
    ..The structure illustrates how nucleotides are selected in a template-directed manner, and provides a structural basis for a metal-assisted mechanism of phosphoryl transfer by a large group of related polymerases...
  10. ncbi Ultrasmooth patterned metals for plasmonics and metamaterials
    Prashant Nagpal
    Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA
    Science 325:594-7. 2009 real plasmonic devices, simple high-throughput methods are needed to fabricate high-quality patterned metals. We combined template stripping with precisely patterned silicon substrates to obtain ultrasmooth pure metal films ..
  11. ncbi How do bacterial cells ensure that metalloproteins get the correct metal?
    Kevin J Waldron
    Institute for Cell and Molecular Biosciences, Medical School, University of Newcastle, UK
    Nat Rev Microbiol 7:25-35. 2009
    ..richly varied and exquisitely attuned to their inorganic partners, yet many metalloproteins still select the wrong metals when presented with mixtures of elements...
  12. ncbi Molecular basis of metal-ion selectivity and zeptomolar sensitivity by CueR
    Anita Changela
    Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, 2205Tech Drive, Evanston, IL 60208, USA
    Science 301:1383-7. 2003
    ..This binding mode is rare among metalloproteins but well suited for an ultrasensitive genetic switch...
  13. doi Metals in neurobiology: probing their chemistry and biology with molecular imaging
    Emily L Que
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Chem Rev 108:1517-49. 2008
  14. ncbi How Saccharomyces cerevisiae copes with toxic metals and metalloids
    Robert Wysocki
    Institute of Genetics and Microbiology, University of Wroclaw, Wroclaw, Poland
    FEMS Microbiol Rev 34:925-51. 2010
    Toxic metals and metalloids are widespread in nature and can locally reach fairly high concentrations. To ensure cellular protection and survival in such environments, all organisms possess systems to evade toxicity and acquire tolerance...
  15. pmc Molecular and ionic mimicry and the transport of toxic metals
    Christy C Bridges
    Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA 31207, USA
    Toxicol Appl Pharmacol 204:274-308. 2005
    ..Surprisingly, little is understood about the mechanisms by which certain metals and metal-containing species gain entry into target cells...
  16. ncbi Noble metals on the nanoscale: optical and photothermal properties and some applications in imaging, sensing, biology, and medicine
    Prashant K Jain
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332, USA
    Acc Chem Res 41:1578-86. 2008
  17. ncbi Nucleases: diversity of structure, function and mechanism
    Wei Yang
    Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, 9000 Rockville Pike, Bldg 5, Rm B1 03, Bethesda, MD 20892, USA
    Q Rev Biophys 44:1-93. 2011
    ..I also find several previously unnoted relationships between different nucleases and shared catalytic configurations...
  18. ncbi Functional specialization within the Fur family of metalloregulators
    Jin Won Lee
    Department of Microbiology, Cornell University, Wing Hall, Ithaca, NY 14853 8101, USA
    Biometals 20:485-99. 2007
    ..Despite numerous studies, the mechanism of metal ion sensing by Fur family proteins is still controversial. Other family members use metal catalyzed oxidation reactions to sense peroxide-stress (PerR) or the availability of heme (Irr)...
  19. ncbi Metals, minerals and microbes: geomicrobiology and bioremediation
    Geoffrey Michael Gadd
    Division of Molecular Microbiology, College of Life Sciences, University of Dundee, Dundee DD1 5EH, UK
    Microbiology 156:609-43. 2010
    ..actively to geological phenomena, and central to many such geomicrobial processes are transformations of metals and minerals...
  20. pmc Structure of a complete integrin ectodomain in a physiologic resting state and activation and deactivation by applied forces
    Jianghai Zhu
    The Immune Disease Institute and Department of Pathology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Mol Cell 32:849-61. 2008
    ..This mechanism propagates allostery over long distances and couples cytoskeleton attachment of integrins to their high-affinity state...
  21. pmc A retrospective comparative study of mortality and causes of death among patients with metal-on-metal and metal-on-polyethylene total hip prostheses in primary osteoarthritis after a long-term follow-up
    Tuomo Visuri
    Research Institute of Military Medicine, Helsinki, Finland
    BMC Musculoskelet Disord 11:78. 2010
    ..We analyzed the causes of total and site-specific mortality among a cohort of patients with MM and with metal-on-polyethylene (MP) THA after a long follow-up time...
  22. ncbi Pseudotumours associated with metal-on-metal hip resurfacings
    H Pandit
    Nuffield Orthopaedic Centre, Oxford, England
    J Bone Joint Surg Br 90:847-51. 2008
    ..We are concerned that with time the incidence of these pseudotumours may increase. Further investigation is required to define their cause...
  23. ncbi Increased osteoblast adhesion on nanophase metals: Ti, Ti6Al4V, and CoCrMo
    Thomas J Webster
    Department of Biomedical Engineering, Purdue University, 1296Patter Building, West Lafayette, IN 47905, USA
    Biomaterials 25:4731-9. 2004
    ..However, to date, interactions of osteoblasts on nanophase compared to conventional metals remain to be elucidated...
  24. ncbi Some precautions in using chelators to buffer metals in biological solutions
    Chris Patton
    Hopkins Marine Station, Stanford University, Pacific Grove, CA 93950, USA
    Cell Calcium 35:427-31. 2004
    ..This communication discusses common misunderstandings and pitfalls in use of these buffers and provides information on choosing the best metal buffer for different experimental situations...
  25. ncbi Microbial metalloproteomes are largely uncharacterized
    Aleksandar Cvetkovic
    Department of Biochemistry and Molecular Biology, University of Georgia, Athens, Georgia 30602, USA
    Nature 466:779-82. 2010
    ..We present here a robust, metal-based approach to determine all metals an organism assimilates and identify its metalloproteins on a genome-wide scale...
  26. pmc Nanoscale surface modifications of medically relevant metals: state-of-the art and perspectives
    Fabio Variola
    Faculty of Engineering, Department of Mechanical Engineering, University of Ottawa, Ottawa, ON K1N 6N5, Canada
    Nanoscale 3:335-53. 2011
    ..and biological processes at the implant/tissue interface is fostering a new trend in designing implantable metals. Cutting-edge expertise and techniques drawn from widely separated fields, such as nanotechnology, materials ..
  27. ncbi Metal-on-metal bearings: the evidence so far
    F S Haddad
    Department of Orthopaedics, University College Hospital, 235 Euston Road, London NW1 2BU, UK
    J Bone Joint Surg Br 93:572-9. 2011
    ..This review examines the literature and contemporary presentations on current clinical dilemmas in metal-on-metal hip replacement...
  28. ncbi Antimicrobial activity of metals: mechanisms, molecular targets and applications
    Joseph A Lemire
    Department of Biological Sciences, University of Calgary, 2500 University Drive NW, Calgary, Alberta T2N 1N4, Canada
    Nat Rev Microbiol 11:371-84. 2013
    b>Metals have been used as antimicrobial agents since antiquity, but throughout most of history their modes of action have remained unclear...
  29. ncbi Patterns of levels of biological metals in CSF differ among neurodegenerative diseases
    Isao Hozumi
    Department of Neurology and Geriatrics, Gifu University, Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    J Neurol Sci 303:95-9. 2011
    We measured the levels of some biological metals: copper (Cu), iron (Fe), magnesium (Mg), manganese (Mn), and zinc (Zn) in the cerebrospinal fluid (CSF) in patients with neurodegenerative diseases (52 patients with amyotrophic lateral ..
  30. ncbi Hydrogen, metals, bifurcating electrons, and proton gradients: the early evolution of biological energy conservation
    William F Martin
    Institute of Molecular Evolution, University of Dusseldorf, 40225 Dusseldorf, Germany
    FEBS Lett 586:485-93. 2012
    ..Electron bifurcation likely figures into the early evolution of biological energy conservation...
  31. ncbi Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals
    J Alam
    Department of Molecular Genetics, Alton Ochsner Medical Foundation, New Orleans, Louisiana 70121
    J Biol Chem 269:1001-9. 1994
    ..Heavy metals activate HO-1 gene transcription and the rat gene contains a putative metal regulatory element (Müller, R. M...
  32. pmc Bio-metals imaging and speciation in cells using proton and synchrotron radiation X-ray microspectroscopy
    Richard Ortega
    Cellular Chemical Imaging and Speciation Group, CNAB, CNRS UMR 5084, University of Bordeaux, 33175 Gradignan, France
    J R Soc Interface 6:S649-58. 2009
    The direct detection of biologically relevant metals in single cells and of their speciation is a challenging task that requires sophisticated analytical developments...
  33. ncbi Untangling amyloid-β, tau, and metals in Alzheimer's disease
    Masha G Savelieff
    Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA
    ACS Chem Biol 8:856-65. 2013
    ..Herein, we present current understanding on the roles of Aβ, tau, and metal ions, placing equal emphasis on each of these proposed features, as well as their inter-relationships in AD pathogenesis...
  34. pmc Risk of cancer with metal-on-metal hip replacements: population based study
    Keijo T Mäkelä
    Department of Orthopaedics and Traumatology, Surgical Hospital, Turku University Hospital, FI 20701 Turku, Finland
    BMJ 345:e4646. 2012
    ..To assess the risk of cancer associated with modern primary metal-on-metal hip replacements...
  35. pmc Risk of cancer in first seven years after metal-on-metal hip replacement compared with other bearings and general population: linkage study between the National Joint Registry of England and Wales and hospital episode statistics
    Alison J Smith
    Musculosketal Research Unit, School of Clinical Sciences, University of Bristol, Avon Orthopaedic Centre, Bristol BS10 5NB, UK
    BMJ 344:e2383. 2012
  36. ncbi Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants
    S Clemens
    Leibniz Institut für Pflanzenbiochemie, Weinberg 3, 06120 Halle Saale, Germany
    Biochimie 88:1707-19. 2006
    Over the past 200 years emissions of toxic heavy metals have risen tremendously and significantly exceed those from natural sources for practically all metals...
  37. ncbi Early failure of metal-on-metal bearings in hip resurfacing and large-diameter total hip replacement: A consequence of excess wear
    D J Langton
    North Tees and Hartlepool NHS Trust, Stockton on Tees and Centre for Rehabilitation, Newcastle University, Newcastle upon Tyne, England
    J Bone Joint Surg Br 92:38-46. 2010
    ..Surgeons must consider implant design, expected component size and acetabular component positioning in order to reduce early failures when performing large-bearing metal-on-metal hip resurfacing and replacement...
  38. ncbi Deformation-mechanism map for nanocrystalline metals by molecular-dynamics simulation
    V Yamakov
    Materials Science Division, Argonne National Laboratory, Argonne, Illinois 60439, USA
    Nat Mater 3:43-7. 2004
    ..c.c. metals. This transition in the deformation mechanism results in a maximum yield strength at a grain size (the 'strongest ..
  39. ncbi Nationwide study of cancer risk among hip replacement patients in Sweden
    L B Signorello
    International Epidemiology Institute, Rockville, MD 20850, USA
    J Natl Cancer Inst 93:1405-10. 2001
  40. pmc Nickel, cobalt, chromium, palladium and gold induce a mixed Th1- and Th2-type cytokine response in vitro in subjects with contact allergy to the respective metals
    J T Minang
    Department of Immunology, Stockholm University, Stockholm, Sweden
    Clin Exp Immunol 146:417-26. 2006
    Nickel (Ni), the main cause of contact allergy to metals, induces in vitro production of both Th1- and Th2-type cytokines in peripheral blood mononuclear cells (PBMC) from allergic subjects...
  41. pmc Metal oxide gas sensors: sensitivity and influencing factors
    Chengxiang Wang
    Key Laboratory for Liquid Solid Structural Evolution and Processing of Materials, Ministry of Education, Shandong University, Jinan, 250061, China
    Sensors (Basel) 10:2088-106. 2010
    ..In this brief review, attention will be focused on changes of sensitivity of conductometric semiconducting metal oxide gas sensors due to the five factors mentioned above...
  42. ncbi Microbes and metals: interactions in the environment
    Götz Haferburg
    Institute of Microbiology, Friedrich Schiller University, Jena, Germany
    J Basic Microbiol 47:453-67. 2007
    ..The strongly interdisciplinary field of bio-geo-interactions spanning from the microorganism to the mineral holds much promise for future developments in both basic research as well as applied sciences...
  43. pmc Cancer risk is not increased after conventional hip arthroplasty
    Tuomo Visuri
    Research Department, Centre for Military Medicine, Finland
    Acta Orthop 81:77-81. 2010
    ..A long latent period is required for solid tumors. We therefore re-analyzed a large THA cohort for cancer...
  44. ncbi Wear mechanisms in metal-on-metal bearings: the importance of tribochemical reaction layers
    Markus A Wimmer
    Department of Orthopedic Surgery, Rush University Medical Center, 1653 West Congress Parkway, Chicago, Illinois 60612, USA
    J Orthop Res 28:436-43. 2010
    ..This novel finding of a mechanically mixed zone of nanocrystalline metal and organic constituents provides the basis for understanding particle release and may help in identifying new strategies to reduce MoM wear...
  45. ncbi Metals and apoptosis: recent developments
    Suresh Vir Singh Rana
    Toxicology Laboratory, Department of Zoology, Ch Charan Singh University, Meerut, India
    J Trace Elem Med Biol 22:262-84. 2008
    ..A variety of toxins can induce apoptosis. Carcinogenic transition metals, viz...
  46. ncbi Dietary exposure to metals and other elements in the 2006 UK Total Diet Study and some trends over the last 30 years
    M Rose
    The Food and Environment Research Agency, Sand Hutton, York YO41 1LZ, UK
    Food Addit Contam Part A Chem Anal Control Expo Risk Assess 27:1380-404. 2010
    Concentrations of 24 elements including metals in the 2006 UK Total Diet Study (TDS) were measured and dietary exposures estimated. Composite samples for the 20 TDS food groups (bread, fish, fruit, etc...
  47. ncbi Melanin as a target for melanoma chemotherapy: pro-oxidant effect of oxygen and metals on melanoma viability
    Patrick J Farmer
    Department of Chemistry, University of California, Irvine, CA 92697 2025, USA
    Pigment Cell Res 16:273-9. 2003
    ..The antimelanoma effect of metal- and oxygen-induced stress appears additive rather than synergistic; both treatments are shown to be significantly less toxic to melanocytes...
  48. ncbi Metals affect soil bacterial and fungal functional diversity differently
    Anna M Stefanowicz
    Institute of Environmental Sciences, Jagiellonian University, Krakow, Poland
    Environ Toxicol Chem 27:591-8. 2008
    Heavy metals can cause a decrease in the taxonomic diversity of soil communities...
  49. pmc SMF-1, SMF-2 and SMF-3 DMT1 orthologues regulate and are regulated differentially by manganese levels in C. elegans
    Catherine Au
    Department of Pediatrics, Vanderbilt University, Nashville, Tennessee, USA
    PLoS ONE 4:e7792. 2009
    ..smf-1 and smf-3 but not in smf-2 mutants, increased Mn exposure led to decreased Fe levels, suggesting that both metals compete for transport by SMF-2...
  50. ncbi Fabrication methods of porous metals for use in orthopaedic applications
    Garrett Ryan
    National University of Ireland, Department of Mechanical and Biomedical Engineering, Nun s Island, Galway, Ireland
    Biomaterials 27:2651-70. 2006
    ..Depending on the porosity, moduli can even be tailored to match the modulus of bone closer than solid metals can, thus reducing the problems associated with stress shielding...
  51. ncbi The PerR transcription factor senses H2O2 by metal-catalysed histidine oxidation
    Jin Won Lee
    Department of Microbiology, Cornell University, Ithaca, New York 14853, USA
    Nature 440:363-7. 2006
  52. ncbi New developments in the understanding of the cation diffusion facilitator family
    Christopher J Haney
    Department of Soil, Water, and Environmental Science, University of Arizona, Shantz Bld number 38 Rm 424, Tucson, AZ 85721, USA
    J Ind Microbiol Biotechnol 32:215-26. 2005
    ..This review seeks to give an overview of the data prompting these conclusions, while presenting additional data whose interpretation is still contentious...
  53. ncbi Metals in cigarette smoke
    David Bernhard
    Vascular Biology Group, Division of Experimental Pathophysiology and Immunology, Innsbruck Medical University, Austria
    IUBMB Life 57:805-9. 2005
    b>Metals are vital for a huge number of physiological processes in the human body, but can also destroy health when the concentration is not within the physiologically favourable range...
  54. pmc Expression of the IRT1 metal transporter is controlled by metals at the levels of transcript and protein accumulation
    Erin L Connolly
    Department of Biological Sciences, Gilman 6044, Dartmouth College, Hanover, NH 03755, USA
    Plant Cell 14:1347-57. 2002
    ..levels of cadmium and zinc than wild-type plants, indicating that IRT1 is responsible for the uptake of these metals and that IRT1 protein levels are indeed increased in these plants...
  55. ncbi Some interesting properties of metals confined in time and nanometer space of different shapes
    M A El-Sayed
    Laser Dynamics Laboratory, School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA 30332 0400, USA
    Acc Chem Res 34:257-64. 2001
  56. ncbi Selenium and 17 other largely essential and toxic metals in muscle and organ meats of Red Deer (Cervus elaphus)--consequences to human health
    Grazyna Jarzynska
    Research Group of Environmental Chemistry, Ecotoxicology and Food Toxicology, Institute of Environmental Sciences and Public Health, University of Gdansk, Poland
    Environ Int 37:882-8. 2011
    ..and deficit to Deer as well as the benefits and risk to humans associated with the essential and toxic metals intake resulting from consumption of Deer meat and products...
  57. ncbi Complexation between Hg(II) and biofilm extracellular polymeric substances: an application of fluorescence spectroscopy
    Daoyong Zhang
    State Key Laboratory of Enviromental Geochemistry, Institute of Geochemistry Chinese Academy of Sciences, Guiyang, 550002, China
    J Hazard Mater 175:359-65. 2010
    ..suggest that EPS from biofilm is a class of important organic ligands for complexation with Hg(II) and may significantly affect the chemical forms, mobility, bioavailability and ecotoxicity of heavy metals in the aquatic environment.
  58. ncbi Cytotoxicity of dental alloys, metals, and ceramics assessed by millipore filter, agar overlay, and MTT tests
    G Sjögren
    NIOM Scandinavian Institute of Dental Materials, Haslum, Norway
    J Prosthet Dent 84:229-36. 2000
    ..Biocompatibility of dental materials is dependent on the release of elements from the materials. In addition, the composition, pretreatment, and handling of the materials influence the element release...
  59. ncbi Novel regulation targets of the metal-response BasS-BasR two-component system of Escherichia coli
    Hiroshi Ogasawara
    Department of Frontier Bioscience, Hosei University, Koganei, Tokyo, Japan
    Microbiology 158:1482-92. 2012
  60. ncbi Type II restriction endonucleases: structure and mechanism
    A Pingoud
    Institut fur Biochemie, Justus Liebig Universitat, Heinrich Buff Ring 58, 35392, Giessen, Germany
    Cell Mol Life Sci 62:685-707. 2005
    ..A major emphasis of this review will be on target site location and the mechanism of catalysis, two problems currently being addressed in the literature...
  61. ncbi Metal ion homeostasis in Bacillus subtilis
    Charles M Moore
    Department of Microbiology, Cornell University, Ithaca, New York 14853 8101, USA
    Curr Opin Microbiol 8:188-95. 2005
    ..A Fur homolog, PerR, functions as an Fe(II)-dependent peroxide stress sensor and regulates putative metal transport and storage functions...
  62. ncbi The biogeochemical cycles of trace metals in the oceans
    F M M Morel
    Department of Geosciences, Princeton University, Princeton, NJ 08544, USA
    Science 300:944-7. 2003
    Planktonic uptake of some essential metals results in extraordinarily low concentrations in surface seawater...
  63. ncbi Trace metal imbalance associated with oxidative stress and inflammatory status in anti-hepatitis C virus antibody positive subjects
    Chih Hung Guo
    Institute of Biomedical Nutrition, Hung Kuang University, Taichung 433, Taiwan, ROC
    Environ Toxicol Pharmacol 33:288-96. 2012
    Toxic and essential trace metals, oxidative stress, and inflammatory status were evaluated in anti-hepatitis C virus (HCV) antibody-positive subjects...
  64. pmc Insights from Caenorhabditis elegans on the role of metals in neurodegenerative diseases
    Ebany J Martinez-Finley
    Division of Clinical Pharmacology and Pediatric Toxicology, Vanderbilt University Medical Center, 11425 MRB IV, 2215 B Garland Ave, Nashville, TN 37232 0414, USA
    Metallomics 3:271-9. 2011
    ..b>Metals are essential for many life processes, but they are also culpable for several neurodegenerative mechanisms...
  65. ncbi Metals and women's health
    M Vahter
    Institute of Environmental Medicine, Karolinska Institutet, Sweden
    Environ Res 88:145-55. 2002
    ..Obviously, gender-related differences in exposure and health effects caused by metals are highly neglected research areas, which need considerable focus in the future.
  66. pmc Corrosion at the cone/taper interface leads to failure of large-diameter metal-on-metal total hip arthroplasties
    Heiko Meyer
    Department of Orthopaedics, Otto von Guericke University, Leipziger Str 44, 39108 Magdeburg, Germany
    Clin Orthop Relat Res 470:3101-8. 2012
    ..Metal-on-metal (MoM) THAs have reduced wear rates compared with metal-on-polyethylene. However, elevated serum metal ion levels and pseudotumors have been reported in large MoM articulations...
  67. ncbi Metallurgical recovery of metals from electronic waste: a review
    Jirang Cui
    Department of Materials Science and Engineering, Norwegian University of Science and Technology NTNU, Alfred Getz vei 2, N 7491 Trondheim, Norway
    J Hazard Mater 158:228-56. 2008
    ..It is showed that the major economic driver for recycling of electronic waste is from the recovery of precious metals. The state of the art in recovery of precious metals from electronic waste by pyrometallurgical processing, ..
  68. ncbi Distribution, correlation and risk assessment of selected metals in urban soils from Islamabad, Pakistan
    Javed Iqbal
    Department of Chemistry, Quaid i Azam University, Islamabad 45320, Pakistan
    J Hazard Mater 192:887-98. 2011
    ..Multivariate statistical approach was used to study the apportionment of selected metals in the soil samples during summer and winter...
  69. ncbi Metal allergy--a review on exposures, penetration, genetics, prevalence, and clinical implications
    Jacob P Thyssen
    National Allergy Research Centre and Department of Dermato Allergology, Gentofte Hospital, University of Copenhagen, Niels Andersens Vej 65, 2900 Hellerup, Denmark
    Chem Res Toxicol 23:309-18. 2010
    ..remains present and should always be taken into consideration when one interprets allergic patch test reactions to metals. Traditionally, nickel, cobalt, and chromium have been the most important contact allergens...
  70. ncbi Mapping metals in Parkinson's and normal brain using rapid-scanning x-ray fluorescence
    Bogdan F Gh Popescu
    Department of Anatomy and Cell Biology, College of Medicine, University of Saskatchewan SK Canada
    Phys Med Biol 54:651-63. 2009
    Rapid-scanning x-ray fluorescence (RS-XRF) is a synchrotron technology that maps multiple metals in tissues by employing unique hardware and software to increase scanning speed...
  71. ncbi Persistence of deposited metals in the lungs after stainless steel and mild steel welding fume inhalation in rats
    James M Antonini
    Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, WV 26505, USA
    Arch Toxicol 85:487-98. 2011
    ..The objectives of this study were to compare the persistence of deposited metals and the inflammatory potential of stainless and mild steel welding fumes, the two most common fumes used in US ..
  72. ncbi The immobilization of recombinant human tropoelastin on metals using a plasma-activated coating to improve the biocompatibility of coronary stents
    Anna Waterhouse
    School of Molecular Bioscience, University of Sydney, NSW 2006, Australia
    Biomaterials 31:8332-40. 2010
    ..We have demonstrated a coating for metal alloys with multifaceted biocompatibility that resists delamination and is non-thrombogenic, with implications for improving coronary stent efficacy...
  73. ncbi Exposure assessment of persistent organic pollutants and metals in Mexican children
    Antonio Trejo-Acevedo
    Departamento de Toxicologia Ambiental, Facultad de Medicina, Universidad Autonoma de San Luis Potosi, Avenida Venustiano Carranza 2405, 78210 San Luis Potosi, S L P, Mexico
    Chemosphere 74:974-80. 2009
    ..Mexico have contributed to the reduction in the production or use of some persistent organic pollutants (POPs) and metals. However, monitoring of POPs concentrations in humans living in hot spots is lacking...
  74. ncbi New roles for bacterial siderophores in metal transport and tolerance
    Isabelle J Schalk
    UMR7242, University of Strasbourg CNRS, ESBS, Blvd Sebastien Brant, F 67413 Illkirch, Strasbourg, France
    Environ Microbiol 13:2844-54. 2011
    ..Despite their preference for iron, they can also chelate numerous other metals with variable affinities...
  75. ncbi Retrieval analysis of 240 metal-on-metal hip components, comparing modular total hip replacement with hip resurfacing
    A Matthies
    Department of Musculoskeletal Surgery, Imperial College London, London, United Kingdom
    J Bone Joint Surg Br 93:307-14. 2011
    ..These findings show that failed metal-on-metal hip resurfacing and modular THRs have similar component wear rates and are both associated with raised pre-revision blood levels of metal ions...
  76. ncbi Long-term environmental monitoring of persistent organic pollutants and metals in a chemical/petrochemical area: human health risks
    Marti Nadal
    Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenc 21, 43201 Reus, Catalonia, Spain
    Environ Pollut 159:1769-77. 2011
    ..biphenyls (PCBs), polychlorinated naphthalenes (PCNs) and polycyclic aromatic hydrocarbons (PAHs), as well as some metals are periodically monitored in soil and vegetation samples collected in Tarragona County (Spain)...
  77. ncbi Metals on the move: zinc ions in cellular regulation and in the coordination dynamics of zinc proteins
    Wolfgang Maret
    King s College London, Diabetes and Nutritional Sciences Division, London, UK
    Biometals 24:411-8. 2011
    ..These new findings establish critically important functions of zinc ions and zinc metalloproteins in cellular control...
  78. ncbi Essential metals for nitrogen fixation in a free-living N₂-fixing bacterium: chelation, homeostasis and high use efficiency
    J P Bellenger
    Department of Geosciences, PEI, Guyot Hall, Princeton University, Princeton, NJ 08544, USA
    Environ Microbiol 13:1395-411. 2011
    ..In the growth medium of A. vinelandii, metals are bound to strong complexing agents (metallophores) excreted by the bacterium...
  79. ncbi Covered metal stents for the treatment of biliary complications after orthotopic liver transplantation
    F García-Pajares
    Gastroenterology Service, Liver Transplantation Unit, Rio Hortega Hospital, Valladolid, Spain
    Transplant Proc 42:2966-9. 2010
    ..Covered self-expandable metal stents (CSEMSs) may be an alternative to the current endoscopic standard treatment with periodic plastic stent replacement...
  80. pmc Direct writing of flexible electronics through room temperature liquid metal ink
    Yunxia Gao
    Key Laboratory of Cryogenics, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, China
    PLoS ONE 7:e45485. 2012
  81. ncbi Cementless Metasul metal-on-metal total hip arthroplasties at 13 years
    Filippo Randelli
    Divisione Ortopedia II, IRCCS Policlinico San Donato, 20097 San Donato Milanese, Milan, Italy
    J Arthroplasty 27:186-92. 2012
    ..Metal wear-related aseptic loosening was not the major reason for failure in our Metasul metal-on-metal THAs. Recurrent dislocation was the main reason for revision in our series...
  82. pmc Do ion levels in hip resurfacing differ from metal-on-metal THA at midterm?
    A Moroni
    Department II of Orthopaedics and Traumatology, Bologna University, Rizzoli Orthopaedic Institute, Via G C Pupilli 1, 40136 Bologna, Italy
    Clin Orthop Relat Res 469:180-7. 2011
    ..Metal-on-metal Birmingham hip resurfacing (MOM-BHR) is an alternative to metal-on-metal total hip arthroplasty (MOM-THA), especially for young and/or active patients. However, wear resulting in increased serum ion levels is a concern...
  83. pmc Surgical variables influence metal ion levels after hip resurfacing
    Nicholas M Desy
    Division of Orthopaedic Surgery, Montreal General Hospital, McGill University Health Centre, Montreal, QC, Canada
    Clin Orthop Relat Res 469:1635-41. 2011
    ..However, there exists some controversy regarding the effect of different surgical variables on the concentration of metal ions in whole blood of patients after hip resurfacing...
  84. ncbi The challenges of determining metal-protein affinities
    Zhiguang Xiao
    University of Melbourne, Parkville, Victoria, Australia
    Nat Prod Rep 27:768-89. 2010
    ..On the other hand, transport proteins responsible for 'chaperoning' essential metals to their cellular destinations appear to bind the metal ions selectively (KD < 10(-7) M, both for speciation ..
  85. pmc Crystal structure of the beta beta alpha-Me type II restriction endonuclease Hpy99I with target DNA
    Monika Sokolowska
    International Institute of Molecular and Cell Biology, Trojdena 4, 02 109 Warsaw, Poland
    Nucleic Acids Res 37:3799-810. 2009
    ..g. I-PpoI) and Holliday junction resolvases (e.g. T4 endonuclease VII)...
  86. pmc Histological features of pseudotumor-like tissues from metal-on-metal hips
    Pat Campbell
    J Vernon Luck Sr MD Orthopaedic Research Center, Orthopaedic Hospital UCLA, 2400 S Flower Street, Los Angeles, CA 90007, USA
    Clin Orthop Relat Res 468:2321-7. 2010
    ..The tissue features may help distinguish reactions to high wear from those with suspected metal hypersensitivity...
  87. ncbi Biological metals and Alzheimer's disease: implications for therapeutics and diagnostics
    James A Duce
    The Mental Health Research Institute, Parkville, Victoria 3052, Australia
    Prog Neurobiol 92:1-18. 2010
    ..of metal ions is critical for many physiological functions, particularly in the central nervous system, where metals are essential for development and maintenance of enzymatic activities, mitochondrial function, myelination, ..
  88. ncbi A randomized trial comparing uncovered and partially covered self-expandable metal stents in the palliation of distal malignant biliary obstruction
    Jennifer J Telford
    St Paul s Hospital, Vancouver, British Columbia, Canada
    Gastrointest Endosc 72:907-14. 2010
    ..The most common complication of uncovered biliary self-expandable metal stents (SEMSs) is tumor ingrowth. The addition of an impenetrable covering may prolong stent patency...
  89. ncbi Modeling of metal interaction geometries for protein-ligand docking
    Birte Seebeck
    University of Hamburg, Center for Bioinformatics, Bundesstrasse 43, 20146 Hamburg, Germany
    Proteins 71:1237-54. 2008
    ..Secondly, the new metal interaction model was tested in terms of predicting protein-ligand complexes. In the majority of test cases, the new interaction model resulted in an improved docking accuracy of the top ranking placements...
  90. ncbi Boon and bane of metal ions in medicine
    Katherine H Thompson
    Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada
    Science 300:936-9. 2003
    ..One of the challenges of designing metal-based drugs is to balance the potential toxicity of an active formulation with the substantial positive impact of these increasingly common therapeutic and diagnostic aids...
  91. ncbi Efficacy and safety of fully covered self-expandable metallic stents in biliary complications after liver transplantation: a preliminary study
    Mario Traina
    Mediterranean Institute for Transplantation and Advanced Specialized Therapies University of Pittsburgh Medical Center, Palermo, Italy
    Liver Transpl 15:1493-8. 2009
    ..A cost analysis should be performed in order to evaluate whether to treat transplanted patients suffering from biliary complications with covered self-expandable metallic stent placement as first-line therapy...
  92. ncbi Utility of removable esophageal covered self-expanding metal stents for leak and fistula management
    Shanda H Blackmon
    Department of Surgery, The Methodist Hospital, Houston, Texas 77030, USA
    Ann Thorac Surg 89:931-6; discussion 936-7. 2010
    ..The primary objective of this study was to determine the efficacy and safety of covered self-expanding metal stents when used to treat complicated leaks and fistulas...
  93. ncbi Blood and urine metal ion levels in young and active patients after Birmingham hip resurfacing arthroplasty: four-year results of a prospective longitudinal study
    J Daniel
    The McMinn Centre, 25 Highfield Road, Edgbaston, Birmingham B15 3DP, UK
    J Bone Joint Surg Br 89:169-73. 2007
    ..The levels in this study provide a baseline against which the in vivo wear performance of newer bearings can be compared...
  94. ncbi Controlling ribozyme activity by metal ions
    Joachim Schnabl
    Institute of Inorganic Chemistry, University of Zurich, Winterthurerstrasse 190, CH 8057 Zurich, Switzerland
    Curr Opin Chem Biol 14:269-75. 2010
    ..Comparison of the observed cleavage rates of hammerhead ribozymes with the metal ion affinities of different ligands reveals that these rates correlate perfectly with the intrinsic phosphate affinities of the metal ions involved...
  95. pmc Mithramycin forms a stable dimeric complex by chelating with Fe(II): DNA-interacting characteristics, cellular permeation and cytotoxicity
    Ming Hon Hou
    Institute of Biological Chemistry, Academia Sinica Taipei, 115 Taiwan
    Nucleic Acids Res 33:1352-61. 2005
    ..Evidences obtained in this study suggest that the biological effects caused by the [(Mith)2-Fe(II)] complex may be further explored in the future...
  96. ncbi DMT1: a mammalian transporter for multiple metals
    Michael D Garrick
    Department of Biochemistry, SUNY at Buffalo, Buffalo, NY 14214, USA
    Biometals 16:41-54. 2003
    DMT1 has four names, transports as many as eight metals, may have four or more isoforms and carries out its transport for multiple purposes. This review is a start at sorting out these multiplicities...
  97. ncbi Bioaccumulation of metals and effects of a landfill in small mammals Part III: Structural alterations
    Alejandro Sánchez-Chardi
    Servei de Microscopia, Facultat de Ciencies, Edifici C, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Environ Res 109:960-7. 2009
    ..Garraf landfill located in a protected site (NE Spain) contain several potentially toxic substances such as heavy metals. Here we report the histopathological alterations produced by this pollution in wild specimens of an omnivorous ..
  98. ncbi In-air micro-particle induced X-ray emission analysis of asbestos and metals in lung tissue
    Y Shimizu
    Department of Medicine and Molecular Science, Gunma University Graduate School of Medicine, Gunma, Japan
    Int J Immunopathol Pharmacol 21:567-76. 2008
    ..emission (in-air micro-PIXE) system for assessment of the spatial distribution and content of asbestos and other metals in lung tissue...
  99. ncbi Soluble metals as well as the insoluble particle fraction are involved in cellular DNA damage induced by particulate matter
    Ad M Knaapen
    Particle Research Core, Research Institute for Environmental Health IUF, Dusseldorf, Germany
    Mol Cell Biochem 234:317-26. 2002
    ..OH formation, implicating an important role of H2O2. Moreover, our data indicate that direct 'particle' effects contribute to the genotoxic hazard of ambient particulate matter in lung target cells...
  100. ncbi Do metals inhibit acetylcholinesterase (AChE)? Implementation of assay conditions for the use of AChE activity as a biomarker of metal toxicity
    M F Frasco
    IPBS UMR 5089, Institut de Pharmacologie et de Biologie Structurale, Group de Biophysique et de Biotechnologie des Protéines, Toulouse, France
    Biomarkers 10:360-75. 2005
    ..activity of acetylcholinesterase (AChE) has been shown to be altered by environmental contaminants such as metals. However, the available literature illustrates a background of contradictory results regarding these effects...
  101. ncbi Prediction of 3D metal binding sites from translated gene sequences based on remote-homology templates
    Ronen Levy
    Department of Plant Sciences, Weizmann Institute of Science, Rehovot, Israel
    Proteins 76:365-74. 2009
    ..A web server for prediction of metal binding sites from protein sequence is provided...

Research Grants72

  1. Metals in exhaled breath condensate as COPD biomarkers
    Antonio Mutti; Fiscal Year: 2005
    ..EBC levels of toxic metals and essential trace elements will be measured in COPD patients by electro-thermal atomic absorption spectroscopy (..
  2. Enhanced iron removal with peptide linked chelators targeted to ferritin
    Elizabeth C Theil; Fiscal Year: 2010
    ..used in the transfusions, that cannot be effectively eliminated from the body, a contrast with other required metals and vitamins. The protection against malaria conferred by SCD and THL mutations increases the numbers of carriers...
  3. Novel PET imaging agents for early diagnosis of plaque deposition in Alzheimer's
    Padmakar Kulkarni; Fiscal Year: 2010
    ..Elevated levels of metals (Cu, Zn and Fe) in amyloid plaque are targets for development of therapeutic and diagnostic agents...
  4. Analyzer for Monitoring Personal Environmental Exposure to Fluids and Materials
    MATTHEW CUSACK; Fiscal Year: 2010
    ..Abnormal levels of bio-essential metals (iron, copper, and zinc) as well as toxic trace elements (mercury, lead, cadmium, and arsenic) are known to be ..
    Alvaro Puga; Fiscal Year: 2013
    ..Frequently, these mixtures include a combination of carcinogenic metals and polycyclic aromatic hydrocarbons (PAH)...
  6. Dietary Lipids and Silica-Accelerated Autoimmunity
    James J Pestka; Fiscal Year: 2013
    ..applied to workers who are at increased risk of autoimmunity from exposures to toxicants such as asbestos, heavy metals, trichloroethylene, and pesticides...
  7. GI Endotoxin as an Environmental Trigger in an alpha-Synuclein Transgenic Mouse
    Robert L Nussbaum; Fiscal Year: 2012
    ..These include viral infection, heavy metals, bacterial toxins, microbe-induced inflammation, and chemical agents including pesticides...
  8. Expanded Testing Methods for Elements and Metals in Animal Diagnostic Specimens
    Timothy Baszler; Fiscal Year: 2013
    ..conducted in 2011-2012 revealed over 50 contamination events nationwide attributed to 8 trace elements and heavy metals such as copper, sulfur, lead, arsenic, zinc, selenium and 9 phosphorus...
  9. Human developmental toxicity of metal mixture exposure from e-waste recycling
    Aimin Chen; Fiscal Year: 2010
    ..E-waste contains high levels of several metals (lead [Pb], mercury [Hg], cadmium [Cd], chromium [Cr], manganese [Mn], etc...
  10. Role of Physico-chemical Properties in the Reprotoxicity of Inhaled Cd NP.
    JUDITH TERRY ZELIKOFF; Fiscal Year: 2010
    ..Most non-carbon NP contain one or more toxicologically-active metals, including cadmium (Cd)...
  11. Epidemiological Research on Autism in Jamaica
    Mohammad H Rahbar; Fiscal Year: 2010 glutathione-S-transferase genes (GSTM1, GSTT1, GSTP1), and their potential interactions with these heavy metals in relation to ASD...
  12. Metal Exposure and Children?s Preschool Neurodevelopment
    David C Bellinger; Fiscal Year: 2012
    ..The developing central nervous system is particularly vulnerable to environmental toxicants such as heavy metals. While lead (Pb) poisoning has been extensively studied, the neurotoxicities and dose-effect relationships ..
  13. DNA Repair of Endogenous Lesions in Carcinogenesis
    Rabindra Roy; Fiscal Year: 2010
    ..and/or activity, if any, of DNA glycosylase(s) and/or other rate-limiting BER enzymes by assessing the effects of metals (copper and iron), hydrogen peroxide, and enals in hepatocytes of LEA and LEG rats and comparing the effects with ..
  14. Dioxins and Male Pubertal Growth and Development
    Russ B Hauser; Fiscal Year: 2013
    ..polychlorinated dibenzo-p- dioxins, polychlorinated dibenzofurans and polychlorinated biphenyls (PCBs), and heavy metals, specifically lead...
  15. Continuation of FERN Activities at the Connecticut Agricultural Experiment Statio
    LAURIE J PETERSON-WRIGHT; Fiscal Year: 2013
    ..3) The use of Inductively Coupled Plasma - Mass Spectrometry (ICP-MS) for the identification of toxic metals in foods...
  16. The role of human DNA polymerase eta in the mutagenic response to oxidative stres
    SCOTT DAVID MCCULLOCH; Fiscal Year: 2013
    ..stress is caused by a number of environmental agents such as polycyclic aromatic hydrocarbons like dioxin, heavy metals, pesticides, and ultraviolet and ionizing radiation...
  17. Epidemiological Research on Autism in Jamaica - Phase II
    Mohammad H Rahbar; Fiscal Year: 2013
    ..West Indies (UWI) in Jamaica to investigate the role of the glutathione-S-transferase (GST) genes and five heavy metals (lead, mercury, arsenic, cadmium, manganese) in relation to ASD...
  18. Bangladesh Centre for Global Environmental and Occupational Health
    Dewan Shamsul Alam; Fiscal Year: 2013
    ..due to water arsenic contamination, millions of Bangladeshis may also be exposed to unsafe levels of other toxic metals including lead, nickel, manganese, uranium and chromium...
  19. Environment, Novel Aging Outcomes, and Genetics
    Sung Kyun Park; Fiscal Year: 2013
    ..The proposed career development plan includes working with established experts in metals and air pollution epidemiology, genetic epidemiology, gerontological epidemiology, neurotoxicology, ophthalmology ..
  20. North Carolina Birth Defects Study To Evaluate Pregnancy Exposures (NC BD-STEPS)
    Andrew Olshan; Fiscal Year: 2013
    ..methods for using dried blood spots to investigate potential risk factors for birth defects including toxic metals and other exposures;(6) Participate in collaborative activities and research initiatives with other CBDRP and the ..
  21. The role of trace metals and T-channels in pain
    Slobodan M Todorovic; Fiscal Year: 2013
    ..mutants, we hypothesize that "Substance T" is a low molecular weight peptide that can act as a chelator of trace metals that can increase cellular excitability of nociceptive DRG and DH neurons and consequently modulate pain sensation ..
  22. Transport ATPases: From Molecules to Maladies
    Rajini Rao; Fiscal Year: 2010
    ..Still others control the movement of trace metals, like copper into metalloenzymes...
  23. Histone modifications and respiratory effects of traffic particle exposure
    Lifang Hou; Fiscal Year: 2013
    ..We used personal air monitors and urine biomarkers to measure exposure to PM2.5, its toxic metals, and traffic exhausts on two independent work days with 1-2 week intervals...
  24. Role of ROS-Induced DNA Damage in Mitochondria-Regulated Apoptosis
    Anne Tann; Fiscal Year: 2012
    ..Environmental agents, such as heavy metals, and other genotoxicants also generate ROS due to mitochondrial dysfunction and various oxidases...
  25. Structure and Specificity in Metal Ion Homeostasis
    Amy C Rosenzweig; Fiscal Year: 2013
    ..b>Metals must be handled such that the correct ions are provided to essential enzymes and proteins, but do not accumulate ..
  26. Lead, Cadmium,Arsenic, and cardiovascular risk in children
    Eliseo Guallar; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The main objective of this project is to test the hypothesis that exposure to metals in children will affect their cardiovascular risk and may predispose them to cardiovascular disease...
  27. Elucidating the A. baumannii response to calprotectin-mediated zinc starvation
    BRITTANY MORTENSEN; Fiscal Year: 2013
    ..CP also exhibits antimicrobial activity through sequestration of the essential metals zinc (Zn) and manganese (Mn). CP- mediated Zn chelation inhibits A. baumannii growth, and during A...
  28. System for Decontaminating Well Water for Drinking
    GIRISH SRINIVAS; Fiscal Year: 2010
    ..Not only are dissolved metals a problem, but soluble anions such as perchlorate, nitrate and nitrite are hazardous at higher concentrations...
  29. International Training and Research in Environmental and Occupational Health
    NELSON K STEENLAND; Fiscal Year: 2012
    ..Water contamination by metals is an important problem in both Peru and Chile, where mining has increased and mine wastes have contaminated water ..
  30. Soft Metal, Disulfide, and Cysteine Stresses in Escherichia coli
    James A Imlay; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): The goals of this study are to investigate the mechanisms by which soft metals, cystine import, and cysteine accumulation can perturb the fitness of Escherichia coli...
  31. Training in Environmental Health to Reduce Chronic Disease in Latin America
    Philip J Landrigan; Fiscal Year: 2013
    ..3) exposure to lead and other heavy metals and neurotoxins such as pesticides continue in the developing world and contribute to neurobehavioral effects ..
  32. The Association of Chronic Exposure to Particulate Matter Air Pollutants, Inflamm
    RODRIGO XAVIER ARMIJOS; Fiscal Year: 2013
    ..To identify the elemental composition (e.g., hydrocarbons, quinines, light cations, heavy and transition metals) and sources of outdoor PM2...
  33. Toxic Metal Complexation by de Novo Designed Peptides
    Vincent L Pecoraro; Fiscal Year: 2013
    ..Understanding the interaction of heavy metals with proteins is essential for defining the mechanism of toxicity, developing ways to minimize human exposure and ..
  34. Sorbents for Toxic-Metal Removal in Pharmaceutical Development and Manufacture
    GIRISH SRINIVAS; Fiscal Year: 2013
    DESCRIPTION: The overall project goal is to develop sorbents that remove catalytic metals used in drug synthesis, which if not adequately removed between synthetic steps and from the final active pharmaceutical ingredients, can lead to ..
  35. Identification of Mammalian Genes Promoting Life Extension
    SIU HUNG CHICK; Fiscal Year: 2013
    ..Several long-lived mouse mutants are also resistant to multiple forms of stress, including oxidants, UV, and heavy metals. This relationship holds equally true for the exceptionally long-lived naked mole rat...
  36. Divalent metal-ion transporter DMT1 and its role in intestinal metal-ion uptake
    Bryan Mackenzie; Fiscal Year: 2012
    ..The second premise is that DMT1 serves absorption not only of iron but also of certain other essential metals such as Co and Mn (as well as trace metals such as Ni and V) but that this promiscuity also makes it a major route ..
    Donald A McClain; Fiscal Year: 2013
    ..increased oxidant stress resulting from a novel mechanism of iron interference with mitochondrial uptake of other metals, particularly Mn;(E) Near complete protection from obesity-associated diabetes in mice on a low iron diet;(F) ..
  38. Mycobacterium turberculosis metal transport P-type ATPases
    JOSE M ARGUELLO; Fiscal Year: 2010 overcome macrophage defenses. At the center of its pathogenic strategy is the handling of involved heavy metals (Cu+, Zn2+, Fe2+, Mn2+, etc.), protons and perhaps alkali metals such as K+ and Mg2+. M...
  39. Toxic metals and ion channels in cigarette-smoke induced COPD
    ESTELLE A CORMET BOYAKA; Fiscal Year: 2010 CFTR), and the pro- inflammatory cytokine IL-8 using quantitative RT-PCR, and (2) to measure the level of heavy metals using inductively coupled plasma mass spectroscopy (ICP-MS) in lungs samples from cigarette smokers that developed ..
  40. Healthy Worker Effect, Occupational Exposure to PM and Cardiopulmonary Mortality
    ELLEN AURA EISEN; Fiscal Year: 2013
    ..Oil-based MWF contain polyaromatic hydrocarbons and metals, constituents also present in the fine particulate mass (PM2...
  41. Strategies for Heavy Metal Detoxification
    Gerard Parkin; Fiscal Year: 2013
    ..The purpose of the proposed research is to develop new and innovative detoxification strategies for these metals. Organomercury compounds, in particular, are highly toxic as illustrated by the death of almost two thousand ..
  42. Long-Term Non-Enzymatic Glucose Sensors for an Artificial Pancreas
    NATALIE ANN WISNIEWSKI; Fiscal Year: 2013 the market and under development are either bulky percutaneous probes or implantable devices encased in hard metals or plastics that become surrounded by an avascular tissue capsule over time or are taken up by immune cells (if ..
  43. Black carbon exposure, DNA methylation, airway inflammation in pediatric asthma
    Rachel L Miller; Fiscal Year: 2013
    ..BC levels will be measured by personal monitoring over a 24 hour period repeated 5 days apart and 6 months later. Metals will be measured by residential monitoring over 5 days, repeated 6 months later...
  44. Individual Predoctoral Dental Scientist Fellowship
    MELISSA ANNE TALBERT; Fiscal Year: 2011
    ..Implanted metals are subject to wear and corrosion due to mechanical and environmental factors...
  45. Foundations of Pretargeted Radioimmunotherapy
    KARL D WITTRUP; Fiscal Year: 2013 termed "pretargeting", in which engineered proteins accumulate within tumors and subsequently capture radioactive metals administered later. Mathematical modeling and protein biotechnology are essential components of the project.
  46. Role of Mechanisms of Efflux in Manganese Homeostasis and Detoxification
    Somshuvra Mukhopadhyay; Fiscal Year: 2013
    ..of cytosolic Mn is understudied although efflux plays a significant role in maintaining homeostasis of other metals. We have now identified an important role for efflux of Mn via uptake into the Golgi apparatus followed by ..
  47. Environmentally Triggered Neurodevelopmental Disorders: Focus on Endocrine Disrup
    JOAN MARIE CRANMER; Fiscal Year: 2012
    ..An increasing number of persistent organic pollutants (POPs) and metals have been shown to alter endocrine signaling mediated by thyroid, estrogen and androgen hormones...
  48. EPR and Mossbauer Characterization of Mn and Fe Proteins, Models, Intermediates
    Michael P Hendrich; Fiscal Year: 2013
    ..provided by applicant): Life for all aerobic organisms, including humans, depends on the activation of O2 by metals to provide selective and rapid oxidation of biological molecules...
  49. HPLC-ICP-MS System
    PETER D CARAVAN; Fiscal Year: 2013
    ..REELEVANCE: Funds are requested for an elemental analyzer that will allow quantification and distribution of metals and metalloids in biological tissue...
  50. Field Validation of New XRF Analyzers: Assessing Personal Exposure to Metals
    PATRICK JEREMY PARSONS; Fiscal Year: 2012
    ..analyzer is designed to be used in the field by non-laboratory trained staff to assess human exposure to multiple metals in a variety of sample types (e.g., cosmetics, personal hygiene products) and matrices (e.g...
  51. Metal inhibition of the base excision repair enzymes
    Anton Guliaev; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Metals are known to cause cancer in humans and the general population is unavoidably exposed to various metals, such as Cd2+, Ni2+ and Pb2+...
  52. Developing fluorescent probes for the endogenous gaseous transmitters NO and H2S
    MICHAEL PLUTH; Fiscal Year: 2013
    ..The proposed family of fluorescent probes will use paramagnetic (S=1/2) metals serving the dual role as both fluorescence quencher and NO binding site...
  53. New Optics for Trace Level Detection of Toxins in Environmental and Biological Sa
    ZEWU CHEN; Fiscal Year: 2010
    ..Further, the in-vitro detection of these trace metals could be compared to existing data sets in wider exposure studies such as the Genes, Environment and Health ..
  54. Field-Deployable Monitor to Assess Personal Exposure to Multiple Heavy Metals
    BADAWI M DWEIK; Fiscal Year: 2010
    The toxicity of trace heavy metals found in drinking water, food, and the environment is an area of increasing national and international concern...
  55. Chronic Cadmium Exposure Promotes Breast Cancer Progression
    Maggie C Louie; Fiscal Year: 2012
    ..for the development of hormone refractory breast cancer may involve endocrine disruptors, including heavy metals such as cadmium. Cadmium is an environmental contaminant that enters the body through the diet or cigarette smoke...
  56. Training in Molecular and Mechanistic Toxicology
    Edson X Albuquerque; Fiscal Year: 2012
    ..for their common interest in basic, clinical and ecological research applied to such environmental toxicants as metals, phytoestrogens, dioxins, and insecticides, and interests span from basic to clinical and environmental research...
  57. Combinatorial Metal Oxide Substrates to Enhance Osteogenic Stem Cell Functions
    Jaime E Ramírez-Vick; Fiscal Year: 2012
    ..Specific Aim 1: Develop metal oxide substrates based on titanium that contain gradients of three other metals used as implant materials...
  58. Nanoparticle Brain Delivery of Iron Chelators for AD
    Gang Liu; Fiscal Year: 2010
    ..has shown that iron chelation therapy can benefit Alzheimer's disease (AD) patients by depleting excess metals from the body...
  59. Plk3 in lung cancer
    Dazhong Xu; Fiscal Year: 2012
    ..The study should also contribute to our understanding of the mechanisms underlying the environmental relevant metals such as nickel in lung cancers...
  60. Registry Study of Parkinsons Disease in Denmark
    Beate R Ritz; Fiscal Year: 2010
    ..with PD;specifically, we will evaluate farming and greenhouse occupations (pesticides), metal related industries (metals and solvents), and night shift work (melatonin levels);2) whether certain drugs and medical conditions are ..
  61. Metal Ion Homeostasis in Bacillus subtilis
    John D Helmann; Fiscal Year: 2012
    ..When cells are starved for essential metals, such as iron or zinc, they express complex adaptive responses...
  62. Metabolic Engineering Studies of Extreme Thermoacidophily
    Robert M Kelly; Fiscal Year: 2010 proton pumping for maintaining a near neutral cytosol, resistance to normally toxic levels of base and heavy metals, capacity to grow autotrophically by fixing CO2, heterotrophically on peptides, or mixotrophically by using both ..
    PAUL SALTMAN; Fiscal Year: 1993
    ..and prevention of pathologies associated with both deficiencies and toxicities related to these essential metals. Currently, our three principal research goals are to understand: 1) The mechanisms by which intracellular and ..
    Karl Kelsey; Fiscal Year: 2006
    ..These studies encompass specific exposures to metals and to organo-chlorine compounds...
  65. Carcinogenic Metals And Their Interactions With Other Toxicants
    Max Costa; Fiscal Year: 2010
    DESCRIPTION (provided by applicant) Most Super-fund sites are contaminated with metals mixtures and organic chemicals and a major concern for human exposure to Superfund sites is the possibility of disease, and in particular, cancer ..
  66. Environmental exposure to metal mixtures and kidney disease
    Mary Fox; Fiscal Year: 2009
    ..We propose to determine whether concurrent exposure to a mixture of nephrotoxic metals is associated with clinical measures of kidney disease...
  67. Novel Chelators for Highly Efficient Removal of Toxic Heavy Metals in Humans
    Charles Timchalk; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Exposure to toxic metals like cadmium (Cd), lead (Pb), mercury (Hg), chromate (CrO42-), arsenite (As) (III), and arsenate (AsO43-) are known to induce various diseases that are detrimental to human ..
    Vladimir Torchilin; Fiscal Year: 2006
    ..To attach metals serving as radioisotopes and paramagnetic moieties to an antibody, chelating groups are introduced into a protein ..
  69. PAH/Metal exposure and effects assessment in Chattanooga
    Sean Richards; Fiscal Year: 2004
    ..As a result of the dumping and deposition, polycyclic aromatic hydrocarbons (PAH) and heavy metals have permeated South Chattanooga soil...
    Alice Villalobos; Fiscal Year: 2002
    ..modulation of choroid plexus choline transport by zinc and cadmium as a means to predict the potential for heavy metals to alter choline availability in the brain...
  71. Divalent Metal Transporter: Role in Manganese Toxicity
    JEROME ROTH; Fiscal Year: 2004
    Chronic exposure to the divalent heavy metals, lead, manganese (Mn) and chromium, has all been linked to development of severe and irreversible neurological disorders as well as increased risk to develop Parkinson disease...