lithium chloride

Summary

Summary: A salt of lithium that has been used experimentally as an immunomodulator.

Top Publications

  1. ncbi Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells
    Qi Cao
    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
    Cell Res 16:671-7. 2006
  2. ncbi The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
    S Yasuda
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Mol Psychiatry 14:51-9. 2009
  3. ncbi Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    V Stambolic
    Ontario Cancer Institute, Toronto, Canada
    Curr Biol 6:1664-8. 1996
  4. pmc Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    Philippe Clément-Lacroix
    Prostrakan Pharmaceuticals, 102 route de Noisy, 93230 Romainville, France
    Proc Natl Acad Sci U S A 102:17406-11. 2005
  5. ncbi Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 301:C995-C1007. 2011
  6. pmc Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α
    Zhuyao Wang
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China
    PLoS ONE 8:e55471. 2013
  7. ncbi Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice
    Mehdi Ghasemi
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Epilepsy Behav 18:171-8. 2010
  8. pmc Slowing down DNA translocation through a nanopore in lithium chloride
    Stefan W Kowalczyk
    Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
    Nano Lett 12:1038-44. 2012
  9. ncbi Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice
    Sung E Choi
    Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Kyunggi do 442 749, Republic of Korea
    Vascul Pharmacol 53:264-72. 2010
  10. ncbi Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    Robert F Schwabe
    Department of Medicine, Biochemistry, and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Gastrointest Liver Physiol 283:G204-11. 2002

Detail Information

Publications256 found, 100 shown here

  1. ncbi Glycogen synthase kinase-3beta positively regulates the proliferation of human ovarian cancer cells
    Qi Cao
    Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China
    Cell Res 16:671-7. 2006
    ..Our findings thus suggest that GSK-3beta activity is important for the proliferation of ovarian cancer cells, implicating this kinase as a potential therapeutic target in ovarian cancer...
  2. ncbi The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons
    S Yasuda
    Molecular Neurobiology Section, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Mol Psychiatry 14:51-9. 2009
    ..Our results have strong implications for the therapeutic actions of these two mood stabilizers...
  3. ncbi Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells
    V Stambolic
    Ontario Cancer Institute, Toronto, Canada
    Curr Biol 6:1664-8. 1996
    ..In higher eukaryotes, GSK-3 has been implicated in signal transduction pathways downstream of phosphoinositide 3-kinase and mitogen-activated protein kinases...
  4. pmc Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in mice
    Philippe Clément-Lacroix
    Prostrakan Pharmaceuticals, 102 route de Noisy, 93230 Romainville, France
    Proc Natl Acad Sci U S A 102:17406-11. 2005
    ..We gavage-fed lithium chloride to 8-week-old mice from three different strains (Lrp5(-/-), SAMP6, and C57BL/6) and assessed the effect on ..
  5. ncbi Glycogen synthase kinase-3β is required for the induction of skeletal muscle atrophy
    Koen J P Verhees
    Department of Respiratory Medicine, School for Nutrition, Toxicology and Metabolism NUTRIM, Maastricht University Medical Centre MUMC, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 301:C995-C1007. 2011
    ....
  6. pmc Lithium chloride inhibits vascular smooth muscle cell proliferation and migration and alleviates injury-induced neointimal hyperplasia via induction of PGC-1α
    Zhuyao Wang
    Jiangsu Key Laboratory for Molecular and Medical Biotechnology and College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, China
    PLoS ONE 8:e55471. 2013
    ..Therefore, the purpose of the present study is to determine if lithium chloride (LiCl) retards VSMC proliferation and migration and if PGC-1α mediates the effects of lithium on VSMCs...
  7. ncbi Voltage-dependent calcium channel and NMDA receptor antagonists augment anticonvulsant effects of lithium chloride on pentylenetetrazole-induced clonic seizures in mice
    Mehdi Ghasemi
    Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, P O Box 13145 784, Tehran, Iran
    Epilepsy Behav 18:171-8. 2010
    ....
  8. pmc Slowing down DNA translocation through a nanopore in lithium chloride
    Stefan W Kowalczyk
    Kavli Institute of Nanoscience, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands
    Nano Lett 12:1038-44. 2012
    ..These fundamental insights into the counterion binding to DNA also provide a practical method for achieving at least 10-fold enhanced resolution in nanopore applications...
  9. ncbi Atherosclerosis induced by a high-fat diet is alleviated by lithium chloride via reduction of VCAM expression in ApoE-deficient mice
    Sung E Choi
    Department of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, Kyunggi do 442 749, Republic of Korea
    Vascul Pharmacol 53:264-72. 2010
    ..Here we investigated whether lithium chloride (LiCl), an inhibitor of glycogen synthase kinase-3β (GSK-3β), could counteract atherosclerosis induced by a ..
  10. ncbi Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes
    Robert F Schwabe
    Department of Medicine, Biochemistry, and Biophysics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Am J Physiol Gastrointest Liver Physiol 283:G204-11. 2002
    ..These results indicate that GSK-3 protects hepatocytes from TNF-alpha-induced apoptosis through p65 phosphorylation and upregulation of NF-kappaB transactivation...
  11. ncbi Inhibition of glycogen synthase kinase-3beta activity is sufficient to stimulate myogenic differentiation
    Jos L J Van Der Velden
    Department of Respiratory Medicine, Maastricht University, Maastricht, The Netherlands
    Am J Physiol Cell Physiol 290:C453-62. 2006
    ..We assessed whether pharmacological inhibition of GSK-3beta with lithium chloride (LiCl) was sufficient to stimulate myogenesis...
  12. ncbi Lithium stimulates proliferation in cultured thyrocytes by activating Wnt/beta-catenin signalling
    A S Rao
    Department of Gastroenterology, Hepatology and Endocrinology, Medical School Hannover, Carl Neuberg Strasse 1, D 30625 Hannover, Germany
    Eur J Endocrinol 153:929-38. 2005
    ..Here we investigated the potential modulation of Wnt/beta-catenin signalling under lithium treatment in primary and neoplastic human thyrocytes...
  13. pmc Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway
    Amanda K Silva
    Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Mol Vis 16:36-45. 2010
    ..In this study, we investigated whether the Wnt pathway activator lithium chloride (LiCl) regulates proliferation of retinoblastoma cancer stem-like cells.
  14. ncbi The mood stabilizer valproic acid stimulates GABA neurogenesis from rat forebrain stem cells
    Pascal Laeng
    Gene Discovery, Psychiatric Genomics, Inc, Gaithersburg, Maryland 20878, USA
    J Neurochem 91:238-51. 2004
    ....
  15. pmc Insulin and wnt1 pathways cooperate to induce reserve cell activation in differentiation and myotube hypertrophy
    Anne Rochat
    Institut de Genetique Humaine, Centre National de la Recherche Scientifique, UPR 1142, 34396 Montpellier Cedex 5, France
    Mol Biol Cell 15:4544-55. 2004
    ..These data reveal insulin and Wnt/beta-catenin pathways cooperate in muscle cell differentiation through activation and recruitment of satellite cell-like reserve myoblasts...
  16. ncbi Chronic lithium chloride administration attenuates brain NMDA receptor-initiated signaling via arachidonic acid in unanesthetized rats
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Neuropsychopharmacology 31:1659-74. 2006
    ..The results show that it is possible to image NMDA signaling via PLA2 activation and AA release in vivo, and that chronic lithium blocks this signaling, consistent with its suggested mechanism of action in BD...
  17. pmc Glycogen synthase kinase-3beta (GSK3beta) inhibition suppresses the inflammatory response to Francisella infection and protects against tularemia in mice
    Ping Zhang
    Department of Pediatric Dentistry, University of Alabama at Birmingham, Birmingham, AL 35294, United States
    Mol Immunol 46:677-87. 2009
    ..tularensis LVS infection, and suggest that inhibition of GSK3beta may represent a novel therapeutic approach in the treatment of tularemia...
  18. ncbi Lithium increases PGC-1alpha expression and mitochondrial biogenesis in primary bovine aortic endothelial cells
    Ian T Struewing
    Graduate Center for Nutritional Sciences, University of Kentucky, 900 Limestone Street, Lexington, KY 40536, USA
    FEBS J 274:2749-65. 2007
    ....
  19. ncbi A functional role for central glucagon-like peptide-1 receptors in lithium chloride-induced anorexia
    L Rinaman
    Department of Neuroscience, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA
    Am J Physiol 277:R1537-40. 1999
    ..peptide-1 (GLP-1)-receptor signalling contributes to the anorexigenic effects of systemically administered lithium chloride (LiCl)...
  20. ncbi The yeast HAL2 nucleotidase is an in vivo target of salt toxicity
    J R Murguia
    Instituto de Biologia Molecular y Celular de Plantas, Universidad Politecnica de Valencia Consejo Superior de Investigaciones Cientificas, Valencia, Spain
    J Biol Chem 271:29029-33. 1996
    ..In addition to blocking sulfate assimilation by product inhibition of PAPS reductase, PAP accumulation may have other unidentified toxic effects...
  21. pmc Lithium chloride attenuates cell death in oculopharyngeal muscular dystrophy by perturbing Wnt/β-catenin pathway
    A Abu-Baker
    The Montreal Neurological Institute and Hospital, Department of Medicine, McGill University, Montreal, Quebec H3A2B4, Canada
    Cell Death Dis 4:e821. 2013
    ..Here, we explored a pharmacological manipulation of a Wnt signaling pathway using lithium chloride (LiCl), a GSK-3β inhibitor, and observed the enhanced expression of β-catenin protein as well as the ..
  22. ncbi Roles of phospho-GSK-3β in myocardial protection afforded by activation of the mitochondrial K ATP channel
    Yoshiaki Terashima
    Division of Cardiology, Second Department of Internal Medicine, Sapporo Medical University School of Medicine, South 1 West 16, Chuo Ku, Sapporo 060 8543, Japan
    J Mol Cell Cardiol 49:762-70. 2010
    ..Inhibition of CypD-ANT interaction may contribute to mK(ATP)-induced myocardial protection, though it is not the sole mechanism of phospho-GSK-3β-mediated cytoprotection...
  23. ncbi GSK3b-inhibitor lithium chloride enhances activation of Wnt canonical signaling and osteoblast differentiation on hydrophilic titanium surfaces
    C Galli
    Sez Odontostomatologia, University of Parma, Parma, Italy
    Clin Oral Implants Res 24:921-7. 2013
    ..This study investigated whether stimulation of Wnt signaling by GSK3b inhibitor lithium chloride (LiCl) could affect the response of mesenchymal or osteoblastic cells growing on titanium surfaces with ..
  24. ncbi Early gene response in lithium chloride induced apoptosis
    W V Zhang
    Division of Surgery, Faculty of Medicine and Health Science, University of Auckland, Grafton, Auckland, New Zealand
    Apoptosis 10:75-90. 2005
    Depending on the cellular context, lithium chloride can lead to enhanced proliferation, cell cycle arrest or apoptosis in mammalian cells...
  25. ncbi Experimental dissociation of neural circuits underlying conditioned avoidance and hypophagic responses to lithium chloride
    Linda Rinaman
    Department of Neuroscience, Univ of Pittsburgh, A210 Langley Hall, Pittsburgh, PA 15260, USA
    Am J Physiol Regul Integr Comp Physiol 293:R1495-503. 2007
    ..To determine whether NST NA neurons also are necessary for lithium chloride (LiCl) to inhibit food intake and/or to support conditioned avoidance behavior, saporin toxin conjugated to ..
  26. pmc Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques
    Inge De Meyer
    Division of Pharmacology, University of Antwerp, Antwerp, Belgium
    Br J Pharmacol 162:1410-23. 2011
    b>Lithium chloride (LiCl) inhibits inositol monophosphatase (IMPase) at therapeutic concentrations...
  27. ncbi Lithium sensitizes tumor cells in an NF-kappa B-independent way to caspase activation and apoptosis induced by tumor necrosis factor (TNF). Evidence for a role of the TNF receptor-associated death domain protein
    P Schotte
    Department of Molecular Biology, Unit for Molecular Signal Transduction in Inflammation, Flanders Interuniversity Institute for Biotechnology and Ghent University, 9000 Ghent, Belgium
    J Biol Chem 276:25939-45. 2001
    ..Here we show that the TNF-sensitizing effect of lithium chloride (LiCl) is independent of the type of cell death, either necrosis or apoptosis...
  28. ncbi Modulation of the development of human monocyte-derived dendritic cells by lithium chloride
    Ko Jiunn Liu
    National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan
    J Cell Physiol 226:424-33. 2011
    ..cells (DC) play a central role in regulating immune responses, this study investigated the influence of lithium chloride (LiCl) on the development and function of DC...
  29. pmc C-fos expression in the rat brain following lithium chloride-induced illness
    Justin St Andre
    Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA
    Brain Res 1135:122-8. 2007
    The present study examined c-Fos expression in selected brain areas consequent to administration of lithium chloride, the typical illness-inducing agent used in laboratory studies of conditioned taste aversion...
  30. ncbi Glycogen synthase kinase 3-β: a master regulator of toll-like receptor-mediated chronic intestinal inflammation
    Claudia Hofmann
    Department of Internal Medicine I, Regensburg University Medical Center, Germany
    Inflamm Bowel Dis 16:1850-8. 2010
    ..The aim of this study was to assess the role of GSK3-β activity in chronic intestinal inflammation...
  31. ncbi Enhancement of vinorelbine-induced cytotoxicity and apoptosis by clomipramine and lithium chloride in human neuroblastoma cancer cell line SH-SY5Y
    Ayhan Bilir
    Department of Histology and Embryology, Faculty of Medicine, Istanbul University, Istanbul, Turkey
    J Neurooncol 100:385-95. 2010
    The aim of this work is to investigate whether clomipramine (CIM) and lithium chloride (LiCl) potentiate the cytotoxicity of vinorelbine (VNR) on SH-SY5Y human neuroblastoma cells in vitro and whether midkine (MK) can be a resistance ..
  32. ncbi Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo
    Qing Zhu
    Department of Medical Oncology, The First Affiliated Hospital, College of Medicine, Xi an Jiaotong University, Xi an, China
    Prostate 71:835-45. 2011
    ..We previously reported that suppression of GSK-3 activity with lithium chloride (LiCl) or small chemical inhibitors impaired cellular DNA synthesis and reduced cell proliferation in ..
  33. ncbi Differential patterns of neuronal activation in the brainstem and hypothalamus following peripheral injection of GLP-1, oxyntomodulin and lithium chloride in mice detected by manganese-enhanced magnetic resonance imaging (MEMRI)
    James R C Parkinson
    Department of Investigative Medicine, Hammersmith Hospital, Imperial College London, UK
    Neuroimage 44:1022-31. 2009
    ..to peripheral injection of the anorexigenic agents glucagon-like peptide-1 (GLP-1), oxyntomodulin (OXM) and lithium chloride. Administration of both GLP-1 and OXM resulted in a significant increase in signal intensity (SI) in the area ..
  34. pmc In AbetaPP-overexpressing cultured human muscle fibers proteasome inhibition enhances phosphorylation of AbetaPP751 and GSK3beta activation: effects mitigated by lithium and apparently relevant to sporadic inclusion-body myositis
    Chiara Terracciano
    Department of Neurology, USC Neuromuscular Center, University of Southern California Keck, School of Medicine, Good Samaritan Hospital, Los Angeles, California 90017, USA
    J Neurochem 112:389-96. 2010
    ..2) In biopsied s-IBM muscle fibers, GSK3beta is significantly activated and AbetaPP is phosphorylated on Thr724. Accordingly, treatment with lithium, or other GSK3beta inhibitors, might benefit s-IBM patients...
  35. pmc Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors
    Joel T Adler
    Department of Surgery, University of Wisconsin, Clinical Science Center, Madison, 53792, USA
    Ann Surg Oncol 16:481-6. 2009
    ..We hypothesized that lower-dose combination therapy of HDAC inhibitors and lithium chloride could achieve similar growth inhibition to that of the drugs alone...
  36. ncbi Lithium chloride preconditioning optimizes skeletal myoblast functions for cellular cardiomyoplasty in vitro via glycogen synthase kinase-3beta/beta-catenin signaling
    W J Du
    Department of Cardiology, Second Clinical College, Harbin Medical University, Harbin, China
    Cells Tissues Organs 190:11-9. 2009
    ..These findings suggest that LiCl preconditioning may be a novel strategy to optimize SkM function for cellular cardiomyoplasty in vitro...
  37. ncbi Lithium chloride attenuates BMP-2 signaling and inhibits osteogenic differentiation through a novel WNT/GSK3- independent mechanism
    Jingjing Li
    Department of Medicine, McGill University, Montreal, QC, Canada
    Bone 48:321-31. 2011
    ..Our work suggests the presence of a novel GSK3/WNT-independent mechanism of lithium action during the early stages of osteogenic differentiation...
  38. pmc Salt tolerance and methionine biosynthesis in Saccharomyces cerevisiae involve a putative phosphatase gene
    H U Gläser
    European Molecular Biology Laboratory, Heidelberg, Germany
    EMBO J 12:3105-10. 1993
    ..Accordingly, methionine supplementation improves the tolerance of yeast to NaCl and LiCl. These results demonstrate an unsuspected interplay between methionine biosynthesis and salt tolerance...
  39. ncbi Lithium reduces tumorigenic potential in response to EGF signaling in human colorectal cancer cells
    Flavia Vidal
    Divisao de Biologia Celular, Centro de Pesquisas, Instituto Nacional do Cancer, Rua André Cavalcanti 37, 5 andar, Rio de Janeiro CEP 20230 051, Brazil
    Int J Oncol 38:1365-73. 2011
    ..We used Caco-2 cells, a well-established model used to study CRC, and treatments with lithium chloride, as a modulator of the Wnt/β-catenin pathway, and with EGF as an inducer of EGFR signaling...
  40. ncbi Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus
    Xiuwen Sui
    Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northeast Agricultural University, 59 Mucai Street, Xiangfang District, 150030 Harbin, China
    Antiviral Res 85:346-53. 2010
    ..In parallel, lithium chloride (LiCl), a chemical reagent with potential antiviral activity was compared with DG for their inhibitory ..
  41. ncbi Phosphorylation of tau by glycogen synthase kinase 3beta in intact mammalian cells influences the stability of microtubules
    H Sang
    Department of Cell Biology and Genetics, College of Life Science, Peking University, Beijing 100871, China
    Neurosci Lett 312:141-4. 2001
    ..The bundles induced by GSK-3beta phosphorylated tau were sensitive to colchicine, and could be reversed by the addition of LiCl, an inhibitor of GSK-3beta...
  42. ncbi Flavor aversion learning induced by lithium chloride in reptiles but not in amphibians
    Sebastien Paradis
    Department of Physiology, Faculty of Medicine, Centre de recherche sur le métabolisme énergétique CREME, Laval University, Laval, Que G1K 7P4, Canada
    Behav Processes 67:11-8. 2004
    ..After intake of the novel food, the animals received i.p. injection of either lithium chloride (LiCl), an effective illness inducer, or a saline solution...
  43. ncbi Lithium chloride protects retinal neurocytes from nutrient deprivation by promoting DNA non-homologous end-joining
    Jing Zhuang
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, 54 S Xianlie Road, Guangzhou, Guangdong 510060, China
    Biochem Biophys Res Commun 380:650-4. 2009
    b>Lithium chloride is a therapeutic agent for treatment of bipolar affective disorders. Increasing numbers of studies have indicated that lithium has neuroprotective effects...
  44. pmc Estradiol and lithium chloride specifically alter NMDA receptor subunit NR1 mRNA and excitotoxicity in primary cultures
    James J Valdes
    Florida International University, Department of Biological Sciences, 229 Health and Life Sciences Building, 11200 SW 8th St, Miami, FL 33199, USA
    Brain Res 1268:1-12. 2009
    ..using primary cell cultures from the cortex and hippocampus of C57BL/6J fetal mice pretreated with E2, lithium chloride (LiCl) and combined E2/LiCl for 12, 24 or 48 h...
  45. pmc Glycogen synthase kinase 3 has a limited role in cell cycle regulation of cyclin D1 levels
    Ke Yang
    Department of Molecular Genetics, The Lerner Research Institute, The Cleveland Clinic Foundation, 9500 Euclid Avenue, Cleveland OH, USA
    BMC Cell Biol 7:33. 2006
    ....
  46. ncbi Chronic lithium chloride administration to rats decreases brain protein level of epsilon (epsilon) subunit of eukaryotic initiation factor-2B
    Francesca Bosetti
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, 9000 Rockville Pike, Building 10, Room 6N202, Bethesda, MD 20892, USA
    Neurosci Lett 327:71-3. 2002
    ..to quantify the protein level of the catalytic epsilon (epsilon) subunit of eIF-2B in brains of rats fed lithium chloride (LiCl) for 6 weeks so as to produce a brain lithium concentration that is therapeutically effective in ..
  47. ncbi Lithium enhances the neuronal differentiation of neural progenitor cells in vitro and after transplantation into the avulsed ventral horn of adult rats through the secretion of brain-derived neurotrophic factor
    Huanxing Su
    Department of Anatomy, Development and Growth, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China
    J Neurochem 108:1385-98. 2009
    ....
  48. ncbi Inactivation of glycogen synthase kinase-3beta, a downstream target of the raf-1 pathway, is associated with growth suppression in medullary thyroid cancer cells
    Muthusamy Kunnimalaiyaan
    University of Wisconsin, H4 750 Clinical Science Center, 600 Highland Avenue, Madison, WI 53792, USA
    Mol Cancer Ther 6:1151-8. 2007
    ..Inactivation of GSK-3beta in TT cells with well-known GSK-3beta inhibitors such as lithium chloride (LiCl) and SB216763 is associated with both growth suppression and a significant decrease in neuroendocrine ..
  49. ncbi Differential effects of the selective orexin-1 receptor antagonist SB-334867 and lithium chloride on the behavioural satiety sequence in rats
    Y Ishii
    Behavioural Pharmacology Laboratory, School of Psychology, University of Leeds, Leeds LS2 9JT, UK
    Physiol Behav 81:129-40. 2004
    ..In this context, Experiment 1 confirmed a significant anorectic effect of 90 (but not 60) mg/kg lithium chloride (LiCl) in male rats presented with palatable mash in the home-cage environment...
  50. ncbi Taste aversion in rats induced by forced swimming, voluntary running, forced running, and lithium chloride injection treatments
    Takahisa Masaki
    Psychology Section, Department of Integrated Psychological Science, Kwansei Gakuin University, Nishinomiya, Hyogo 662 8501, Japan
    Physiol Behav 88:411-6. 2006
    ..8 m/min), optional running in the apparatus consisting of an activity wheel and a side room (120 min), and a lithium chloride (LiCl, 0.15 M LiCl at 2% of body weight) injection...
  51. ncbi Lateral hypothalamic lesions impair flavour-nutrient and flavour-toxin trace learning in rats
    Khalid Touzani
    Department of Psychology, Brooklyn College and the Graduate School, The City University of New York, Brooklyn, NY 11210, USA
    Eur J Neurosci 16:2425-33. 2002
    ..The same rats learned to avoid flavours paired with i.g. lactose or lithium chloride over short delays (15-30 min), but were impaired, relative to controls, at a long conditioned-unconditioned ..
  52. ncbi Differentiating human NT2/D1 neurospheres as a versatile in vitro 3D model system for developmental neurotoxicity testing
    E J Hill
    School of Life and Health Sciences, Aston University, Aston Triangle, Birmingham, UK
    Toxicology 249:243-50. 2008
    ..Acrylamide reduced neurosphere viability but did not affect neuronal protein marker expression. Overall, this NT2/D1-based neurosphere model of neurogenesis, may provide the basis for a model of developmental neurotoxicity in vitro...
  53. ncbi [Effects of lithium chloride on the proliferation and apoptosis of K562 leukemia cells]
    Hua Rong Tang
    Department of Blood Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, China
    Hunan Yi Ke Da Xue Xue Bao 28:357-60. 2003
    To investigate the effects of lithium chloride on the proliferation and apoptosis of human leukemia cell line (K562).
  54. ncbi Biphasic dose-dependent effect of lithium chloride on survival of human hormone-dependent breast cancer cells (MCF-7)
    Muralidharan Suganthi
    Department of Endocrinology, Dr ALM Post Graduate Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, 600 113, India
    Biol Trace Elem Res 150:477-86. 2012
    Lithium, the first element of Group I in the periodic system, is used to treat bipolar psychiatric disorders. Lithium chloride (LiCl) is a selective inhibitor of glycogen synthase kinase-3β (GSK-3β), a serine/threonine kinase that ..
  55. ncbi Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) receptor antagonist attenuates lithium chloride-induced c-Fos induction in rat brainstem
    T E Thiele
    Department of Psychology, University of Washington, Box 351525, Seattle, WA, USA
    Brain Res 801:164-70. 1998
    Central infusion of glucagon-like peptide-1-(7-36) amide (GLP-1) and intraperitoneal (i.p.) injection of lithium chloride (LiCl) produce similar patterns of c-Fos induction in the rat brain...
  56. ncbi Dendritic cells from the elderly display an intrinsic defect in the production of IL-10 in response to lithium chloride
    Sudhanshu Agrawal
    Division of Basic and Clinical Immunology, Department of Medicine, University of California, Irvine, CA 92697, USA
    Exp Gerontol 48:1285-92. 2013
    ..The effect of Lithium Chloride (LiCl) was compared on the response of TLR4 agonist, LPS and TLR2 agonist, PAM3CSK4 stimulated aged and young ..
  57. pmc Tol1, a fission yeast phosphomonoesterase, is an in vivo target of lithium, and its deletion leads to sulfite auxotrophy
    R Miyamoto
    Department of Pharmacology, Kobe University School of Medicine, Kobe 650 0017, Japan
    J Bacteriol 182:3619-25. 2000
    ....
  58. ncbi Lithium-induced changes in gravicurvature, statocyte ultrastructure and calcium balance of pea roots
    N A Belyavskaya
    Institute of Botany, Kiev, Ukraine
    Adv Space Res 27:961-6. 2001
    ..The work demonstrates the key role played by second messengers (Ca2+ and IP3) in a gravity perception and response...
  59. ncbi Neurite outgrowth and differentiation of rat cortex progenitor cells are sensitive to lithium chloride at non-cytotoxic exposures
    Kavita M Jeerage
    Materials Reliability Division, National Institute of Standards and Technology, Boulder, CO 80305, USA
    Neurotoxicology 33:1170-9. 2012
    ..Cultures exposed to 30 mmol/L or 10 mmol/L lithium chloride (LiCl) had significantly lower metabolic activity than control cultures, as reported by adenosine ..
  60. ncbi Lithium chloride alleviates neurodegeneration partly by inhibiting activity of GSK3β in a SCA3 Drosophila model
    Dan dan Jia
    Department of Neurology, Xiangya Hospital, Central South University, Changsha, China
    Cerebellum 12:892-901. 2013
    ..We showed that chronic treatment with lithium chloride at specific doses notably prevented eye depigmentation, alleviated locomotor disability, and extended the ..
  61. pmc Lithium chloride promotes host resistance against Pseudomonas aeruginosa keratitis
    Kang Chen
    Department of Immunology, Institute of Human Virology, Zhongshan School of Medicine, Sun Yat Sen University, Guangzhou, China
    Mol Vis 19:1502-14. 2013
    To explore the role of lithium chloride (LiCl) in Pseudomonas aeruginosa (PA) keratitis.
  62. ncbi Chemical modification of silk sericin in lithium chloride/dimethyl sulfoxide solvent with 4-cyanophenyl isocyanate
    Hidetoshi Teramoto
    New Silk Materials Laboratory, Insect Biotechnology and Sericology Department, National Institute of Agrobiological Sciences, 1 4 8 Gohda, Okaya, Nagano 394 0021, Japan
    Biomacromolecules 5:1392-8. 2004
    ..These results demonstrate that chemical modification of sericin using LiCl/DMSO solvent markedly alters its characteristics...
  63. pmc Effect of lithium chloride and antineoplastic drugs on survival and cell cycle of androgen-dependent prostate cancer LNCap cells
    Vajihe Azimian-Zavareh
    Department of Animal Biology, Developmental Biology Lab, School of Biology, University College of Science, University of Tehran, Tehran, Iran
    Indian J Pharmacol 44:714-21. 2012
    ..This study sought to determine the usefulness of lithium chloride (LiCl) as a highly selective inhibitor of GSK-3β to increase the sensitivity of LNCap cells to doxorubicin (..
  64. pmc Mitogen-activated protein kinase in the amygdala plays a critical role in lithium chloride-induced taste aversion learning
    Bumsup Kwon
    Department of Biological Science, Program in Neuroscience, Florida State University, Tallahassee, FL 32306 4295, USA
    Neurobiol Learn Mem 97:132-9. 2012
    ..However, the functional role of MAPK activation in the amygdala during lithium chloride (LiCl)-induced CTA learning has not been established...
  65. ncbi Pharmacokinetics and toxic effects of lithium chloride after intravenous adminstration in conscious horses
    C L Hatfield
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Canada
    Am J Vet Res 62:1387-92. 2001
    OBJECTIVE: To determine the pharmacokinetics and toxic effects associated with IV administration of lithium chloride (LiCl) to conscious healthy horses. ANIMALS: 6 healthy Standardbred horses. PROCEDURE: Twenty 3-mmol boluses of LiCl (0...
  66. ncbi Flavour exposures after conditioned aversion or preference trigger different brain processes in anaesthetised pigs
    A Gaultier
    INRA, UMR1079 SENAH, 35590 Saint Gilles, France
    Eur J Neurosci 34:1500-11. 2011
    ..This study reveals the unconscious cognitive dimension evoked by food flavours according to the individual experience, and highlights the importance of the food sensory image on hedonism and anticipatory eating behaviour...
  67. pmc Genetic analysis of salt tolerance in arabidopsis. Evidence for a critical role of potassium nutrition
    J K Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Plant Cell 10:1181-91. 1998
    ....
  68. ncbi Chronic lithium chloride administration to rats elevates glucose metabolism in wide areas of brain, while potentiating negative effects on metabolism of dopamine D2-like receptor stimulation
    Mireille Basselin
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bldg 9, Room 1S126, 9 Memorial Drive, Bethesda, MD 20892 0947, USA
    Psychopharmacology (Berl) 187:303-11. 2006
    ..Knowing these effects may elucidate and localize the therapeutic action of lithium in bipolar disorder...
  69. ncbi Lateral parabrachial lesions impair lithium chloride-induced aversive responses but not saccharin-induced flavor preference
    Montserrat Navarro
    Departamento de Neurociencia y Ciencias de la Salud, Universidad de Almeria, 04120 Almeria, Spain
    Brain Res 990:195-202. 2003
    ..The main objective in the present study was to further evaluate the functional role of the lPB in lithium chloride-induced behavioral/physiological responses...
  70. pmc Lithium chloride and inhibition of glycogen synthase kinase 3β as a potential therapy for serous ovarian cancer
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Int J Gynecol Cancer 23:361-6. 2013
    b>Lithium chloride (LiCl) has been shown to demonstrate anticancer properties at supratherapeutic doses...
  71. ncbi The role of contextual conditioning in the effect of reinforcer devaluation on instrumental performance by rats
    Sietse Jonkman
    Behavioural and Clinical Neuroscience Institute and Department of Experimental Psychology, University of Cambridge, Downing Site, Cambridge, United Kingdom
    Behav Processes 83:276-81. 2010
    ....
  72. ncbi Lithium chloride inhibits development along the animal vegetal axis and anterior midline of the squid embryo
    K Crawford
    St Mary s College of Maryland, MD, USA
    Biol Bull 205:181-2. 2003
  73. ncbi Glycogen synthase kinase 3 has a proapoptotic function in Hydra gametogenesis
    Fabian Rentzsch
    Institute of Zoology, University of Darmstadt, Germany
    Dev Biol 278:1-12. 2005
    ..Our experiments show that main functions of GSK3 are evolutionarily conserved and unique to multicellular animals, a conclusion which is additionally supported by the presence of specific regulatory domains in the HyGSK3 protein...
  74. ncbi Inhibition of 20 S and 26 S proteasome activity by lithium chloride: impact on the differentiation of leukemia cells by all-trans retinoic acid
    A M Rice
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 276:42722-7. 2001
    ....
  75. ncbi Lithium chloride and staurosporine potentiate the accumulation of phosphorylated glycogen synthase kinase 3β/Tyr216, resulting in glycogen synthase kinase 3β activation in SH-SY5Y human neuroblastoma cell lines
    Anastasia Noël
    GReViC EA3808, PBS, bat IBMIG, Poitiers, France
    J Neurosci Res 89:755-63. 2011
    ..b>Lithium chloride (LiCl) is usually described to increase pGSK3βSer9 through the PI3K/Akt pathway, resulting in GSK3β ..
  76. ncbi Combination of all-trans retinoic acid and lithium chloride surmounts a retinoid differentiation block induced by expression of Scl and Rbtn2 transcription factors in myeloid leukemia cells
    Anna M Rice
    Department of Pharmacology and Developmental Therapeutics Program, Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Leuk Res 28:399-403. 2004
    ..These findings suggest that if Scl and/or Rbtn2 are involved in the non-responsiveness of AML patients to ATRA-induced differentiation, addition of LiCl may reverse insensitivity...
  77. pmc Impaired conditioned taste aversion learning in spinophilin knockout mice
    C A Stafstrom-Davis
    Program in Neuroscience, Florida State University, Tallahassee, Florida 32306 4340 USA
    Learn Mem 8:272-8. 2001
    ..g., a sucrose solution paired with a malaise-inducing injection of lithium chloride)...
  78. pmc Lithium inhibits invasion of glioma cells; possible involvement of glycogen synthase kinase-3
    Michal O Nowicki
    Dardinger Laboratory for Neuro oncology and Neurosciences, Department of Neurological Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA
    Neuro Oncol 10:690-9. 2008
    ..These data outline previously unidentified pathways and inhibitors that may be useful for the development of novel anti-invasive therapeutics for the treatment of brain tumors...
  79. ncbi Lithium chloride, administered chronically to rats, does not affect the fractional phosphorylation of brain cytosolic phospholipase A2, while reducing its net protein level
    Gayani R Weerasinghe
    Brain Physiology and Metabolism Section, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA
    Brain Res Bull 59:303-6. 2003
    ..Male Fischer-344 rats were fed lithium chloride for 6 weeks, so as to produce a therapeutically equivalent brain lithium concentration; control rats were fed ..
  80. pmc Abstinence-dependent transfer of lithium chloride-induced sucrose aversion to a sucrose-paired cue in rats
    John H Harkness
    Department of Psychology and Program in Behavioral Neuroscience, Western Washington University, 516 High Street, Bellingham, WA 98225 9172, USA
    Psychopharmacology (Berl) 208:521-30. 2010
    ..If the incentive value of a cue depends on the incentive value of the primary reward, devaluing the primary reward should reduce cue reactivity...
  81. pmc Deregulation of Tpl2 and NF-kappaB signaling and induction of macrophage apoptosis by the anti-depressant drug lithium
    Minying Zhang
    Department of Immunology, The University of Texas MD Anderson Cancer Center, 7455 Fannin Street, BOX 902, Houston TX 77030, United States
    Cell Signal 21:559-66. 2009
    ..Consequently, lithium both attenuates LPS-mediated pro-inflammatory gene induction and induces apoptosis in macrophages. These results provide novel insight into the anti-inflammatory function of lithium...
  82. ncbi Additive anticonvulsant effects of agmatine and lithium chloride on pentylenetetrazole-induced clonic seizure in mice: involvement of α₂-adrenoceptor
    Arash Bahremand
    Tehran University of Medical Sciences, School of Medicine, Department of Pharmacology, Iran
    Eur J Pharmacol 666:93-9. 2011
    ..In our study, acute administration of a single effective dose of lithium chloride (30 mg/kg, i.p.) increased the seizure threshold...
  83. ncbi Inhibition of protein phosphatase 2A overrides tau protein kinase I/glycogen synthase kinase 3 beta and cyclin-dependent kinase 5 inhibition and results in tau hyperphosphorylation in the hippocampus of starved mouse
    E Planel
    Mitsubishi Kasei Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194-8511, Japan
    J Biol Chem 276:34298-306. 2001
    ....
  84. ncbi Involvement of nitric oxide-cGMP pathway in the anticonvulsant effects of lithium chloride on PTZ-induced seizure in mice
    Arash Bahremand
    Department of Pharmacology, School of Medicine, Medical Sciences University of Tehran, P O Box 13145 784, Tehran, Iran
    Epilepsy Res 89:295-302. 2010
    ..Injection of a single effective dose of lithium chloride (25 mg/kg) intraperitoneally (i.p.) increased significantly the seizure threshold (P<0.01)...
  85. ncbi Comparative analysis of the effect of glycyrrhizin diammonium and lithium chloride on infectious bronchitis virus infection in vitro
    Jing Li
    College of Veterinary Medicine, Northeast Agricultural University, Harbin, China
    Avian Pathol 38:215-21. 2009
    The effects of glycyrrhizin diammonium (GD) and lithium chloride (LiCl) on cell infection by avian infectious bronchitis virus (IBV) were investigated using cytopathic effect observation, plaque-reduction assay and reverse transcriptase-..
  86. pmc Action mechanisms of lithium chloride on cell infection by transmissible gastroenteritis coronavirus
    Xiaofeng Ren
    College of Veterinary Medicine, Northeast Agricultural University, Harbin, China
    PLoS ONE 6:e18669. 2011
    Transmissible gastroenteritis virus (TGEV) is a porcine coronavirus. Lithium chloride (LiCl) has been found to be effective against several DNA viruses, such as Herpes simplex virus and vaccinia virus...
  87. ncbi c-Fos induction in the rat nucleus of the solitary tract by intraoral quinine infusion depends on prior contingent pairing of quinine and lithium chloride
    T A Houpt
    E W Bourne Behavioral Research Laboratory, Department of Psychiatry, Cornell University Medical College, White Plains, NY 10605, USA
    Physiol Behav 60:1535-41. 1996
    ..prior to conditioning, 2. after 3 noncontingent (unpaired) infusions of quinine and toxic lithium chloride (LiCl) injections, 3. after conditioning with 3 contingent pairings of quinine and LiCl, and 4...
  88. ncbi Accumulation of β-catenin by lithium chloride in porcine myoblast cultures accelerates cell differentiation
    Yingjuan Yang
    Department of Animal Science and Technology, Laboratory of Animal Fat Deposition and Muscle Development, College of Animal Science and Technology, Northwest A and F University, 22 Xinong Road, Yangling, Shaanxi Province 712100, People s Republic of China
    Mol Biol Rep 38:2043-9. 2011
    ..b>Lithium chloride (LiCl) is known to activate canonical Wnt signaling by inhibiting glycogen synthetase kinase-3β and ..
  89. ncbi Lithium chloride regulates connexin43 in skeletal myoblasts in vitro: possible involvement in Wnt/beta-catenin signaling
    W J Du
    Department of Cardiology, The Second Clinical College of Harbin Medical University, Harbin, China
    Cell Commun Adhes 15:261-71. 2008
    ..Here, the aim was to study whether lithium chloride (LiCl) could regulate Cx43 expression and gap junction channel function by mimicking the Wnt/beta-catenin ..
  90. pmc IGF-I activates the mouse type IIb myosin heavy chain gene
    R Andrew Shanely
    Department of Biomedical Sciences, University of Missouri Columbia, Columbia, Missouri 65211, USA
    Am J Physiol Cell Physiol 297:C1019-27. 2009
    ..In summary, IGF-I stimulation of C2C12 myotubes increases mouse type IIb MyHC promoter activity, likely through signaling of PI3K, GSK-3beta, beta-catenin, and a Tcf/Lef binding site at -1,206 to -1,201 bp in the promoter...
  91. ncbi Strain differences in lithium attenuation of d-amphetamine-induced hyperlocomotion: a mouse model for the genetics of clinical response to lithium
    Todd D Gould
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, HHS, Bethesda, MD 20892 3711, USA
    Neuropsychopharmacology 32:1321-33. 2007
    ....
  92. ncbi Glycogen synthase kinase-3beta inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
    Jenny Carmichael
    Department of Medical Genetics, Cambridge Institute for Medical Research, Wellcome Trust Medical Research Council Building, Addenbrooke s Hospital, Hills Road, Cambridge CB2 2XY, UK
    J Biol Chem 277:33791-8. 2002
    ..Since LiCl can protect against polyglutamine toxicity in cell lines, it is an excellent candidate for further in vivo therapeutic trials...
  93. ncbi Nuclear beta-catenin is required to specify vegetal cell fates in the sea urchin embryo
    C Y Logan
    Developmental, Cellular and Molecular Biology Group and the Department of Zoology, Duke University, Durham, NC 27708, USA
    Development 126:345-57. 1999
    ....
  94. pmc Oligoribonuclease is a common downstream target of lithium-induced pAp accumulation in Escherichia coli and human cells
    Undine Mechold
    Institut Pasteur, URA 2171, Unité de Génétique des Génomes Bactériens, 75724 Paris Cedex 15, France
    Nucleic Acids Res 34:2364-73. 2006
    ..Our findings point to remarkable conservation of the connection between sulfur- and RNA metabolism between E.coli and humans...
  95. ncbi CCR7-dependent stimulation of survival in dendritic cells involves inhibition of GSK3beta
    Cristina Escribano
    Department of Immunology, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 183:6282-95. 2009
    ..They also suggest that upon stimulation of CCR7, Akt-mediated phosphorylation/inhibition of GSK3beta may be required to allow complete translocations of FOXO and NF-kappaB that confer DCs an extended survival...
  96. ncbi Functional interaction between beta-catenin and FOXO in oxidative stress signaling
    Marieke A G Essers
    Department of Physiological Chemistry and Center for Biomedical Genetics, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, Netherlands
    Science 308:1181-4. 2005
    ..These results demonstrate a role for beta-catenin in regulating FOXO function that is particularly important under conditions of oxidative stress...
  97. ncbi Lithium chloride reinforces the regeneration-promoting effect of chondroitinase ABC on rubrospinal neurons after spinal cord injury
    Leung Wah Yick
    Department of Anatomy, Faculty of Medicine, The University of Hong Kong, Hong Kong
    J Neurotrauma 21:932-43. 2004
    ..The effect of a GSK-3beta inhibitor, lithium chloride (LiCl), on the regeneration of axotomized RST neurons was also assessed...
  98. ncbi In vitro effects of lithium chloride on TNF alpha and IL-6 production by monocytes from breast cancer patients
    A Arena
    Institute of Medical Microbiology, University of Messina, Italy
    J Chemother 9:219-26. 1997
    It is well known that lithium chloride (LiCl) is able to trigger human monocytes to release tumor necrosis factor alpha (TNF alpha)...
  99. ncbi Lithium induces mortality in medulloblastoma cell lines
    Alice Ronchi
    Clinical Department of Radiological and Histopathological Sciences, University of Bologna Alma Mater Studiorum, Via Massarenti 9, 40138 Bologna, Italy
    Int J Oncol 37:745-52. 2010
    ..In conclusion, lithium could be a promising drug in MB, but an accurate molecular profile predictive of drug response still needs to be clarified...
  100. pmc Inhibition of growth in medullary thyroid cancer cells with histone deacetylase inhibitors and lithium chloride
    Joel T Adler
    Endocrine Surgery Research Laboratories, Department of Surgery, University of Wisconsin, Madison, Wisconsin 53792, USA
    J Surg Res 159:640-4. 2010
    ..valproic acid (VPA) and suberoyl bis-hydroxamic acid (SBHA) activate the Notch1 signaling pathway, while lithium chloride inhibits the glycogen synthase kinase-3ss (GSK-3ss) pathway...
  101. ncbi Lithium chloride inhibits the coronavirus infectious bronchitis virus in cell culture
    Sally M Harrison
    Institute of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK
    Avian Pathol 36:109-14. 2007
    ..Effective antiviral agents may therefore be advantageous in the treatment of IBV. Lithium chloride (LiCl) is a potent inhibitor of the DNA virus herpes simplex virus but not RNA viruses...

Research Grants63

  1. Neural basis of learned food aversion and nausea
    CHARLES HORN; Fiscal Year: 2009
    ..this issue experiments will be conducted to examine the effects of cisplatin (a chemotherapy agent) and lithium chloride (LiCI) (treatments that produce nausea in humans) on visceral afferent nerve activity and brain and spinal ..
  2. GSK3-beta Signaling in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2013
    ..an increase in phosphorylated, inactive GSK3B, and that treatment of MTC cells with GSK3B inhibitors, such as lithium chloride and SB216763, can recapitulate the effects of raf-1...
  3. Central Viscerosensory Circuits - Structure and Function
    LINDA M RINAMAN; Fiscal Year: 2013
    ..examine NA axonal collateralization and ascending pathway recruitment by a malaise- inducing agent, lithium chloride (LiCl)...
  4. Importance of Beta-Catenin Signaling in Osteocytes Associated with Anabolic Load
    Shiva P Kotha; Fiscal Year: 2012
    ..In this application, we evaluate the dosage of a pharmacological agent (lithium chloride) that can synergize with mechanical loading to activate a powerful pathway (the Wnt/b-catenin signaling) in ..
  5. Molecular Mechanisms Mediating Recovery after SCI-Induced Hemidiaphragmatic Paral
    KWAKU DANIEL NANTWI; Fiscal Year: 2010
    ..trigger (primo movens) for functional recovery in the HC2 model and (2) that inhibition of GSK-3b with lithium chloride, an antidepressant medication can induce functional recovery in the HC2 model via BDNF expression and feed-..
  6. Neural Mechanisms fo Extinction and Spontaneous Recovery
    G Mickley; Fiscal Year: 2009
    ..p. injection of Lithium Chloride (LiCI;US) and then administer EXT trials using 2 different methods...
  7. CENTRAL HYPERALGESIA SYSTEMS AND ANALGESIC EFFICACY
    ERIC WIERTELAK; Fiscal Year: 1999
    ..An aversive internal state is produced through intraperitoneal (IP) injection of lithium chloride (LiCl) or lipopolysaccharides (Endotoxin), which induce a potent cutaneous hyperalgesia as measured by the ..
  8. Drugs of Abuse, Gender Differences, and Protection by Sweets
    Angie Cason; Fiscal Year: 2010
    ..drugs of abuse were producing a conditioned taste aversion, similar to that induced by the aversive agent, lithium chloride. More recent evidence, however, suggests that the supressive effects of drugs of abuse are caused by ..
  9. Neural Substrates of Drug-Induced Reward Devaluation
    ANNE BALDWIN; Fiscal Year: 2005
    ..believed that drugs of abuse were actually producing a conditioned taste aversion, similar to that induced by lithium chloride. However there is substantial evidence to suggest that the suppressive effects of drugs of abuse are actually ..
  10. GUSTATORY AVERSIONS AND THE PARABRACHIAL NUCLEUS
    STEPHEN REILLY; Fiscal Year: 1999
    ..He has also provided data that PBNx rats can discriminate tastants, and that they experience the acute toxic effects of lithium chloride.
  11. INFORMATIONAL FACTORS IN LEARNING ABOUT EDIBLES
    Michael Best; Fiscal Year: 1980
    ..One focuses on the deleterious effects on taste-aversion learning of presenting the aversion-inducing agent (lithium chloride in most of the experiments) shortly (30-90 min.) before a taste-toxicosis conditioning trial...
  12. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    Patricia Sue Grigson; Fiscal Year: 2010
    ..e., cocaine and heroin);and (c) Reveal that the nucleus accumbens depends upon an intact thalamocoritical loop to track cocaine's devaluation of a sweet. ..
  13. The Delayed Effects of Phencyclidine: Mechanisms
    Sarah Turgeon; Fiscal Year: 2002
    ..These experiments will begin to identify the mechanisms by which PCP produces schizophrenia-like behaviors in animals, providing insight into potential pathophysiologies underlying schizophrenia in humans. ..
  14. BRAIN GALANIN RECEPTORS AND EPILEPSY
    Andrey Mazarati; Fiscal Year: 2006
    ..abstract_text> ..
  15. Physiology and genetics of food procurement in rodents
    Neil Rowland; Fiscal Year: 2008
    ..The proposed studies will be the first to address the issue of behavioral change induced by anorectics under such conditions of simulated economic costs. [unreadable] [unreadable] [unreadable]..
  16. Cue dependency with intravenous nutrients and nicotine
    Neil Rowland; Fiscal Year: 2007
    ..These studies may help to develop ways in conditioned preferences can be manipulated to prevent or treat certain addictive disorders, including overeating. [unreadable] [unreadable] [unreadable]..
  17. GUSTATORY THALAMUS AND TASTE GUIDED BEHAVIOR
    STEPHEN REILLY; Fiscal Year: 2004
    ..The results of the research proposed in this application will significantly enhance our understanding of the information processing role(s) of the thalamic taste area of the rat. ..
  18. PERIPHERAL GUSTATORY PROCESSING
    MARION ELIZABETH FRANK; Fiscal Year: 2010
    ..Also, elimination of taste disorders would improve the quality of life that depends on enjoyment of food and drink, a universal human need contributing much to human sociality. ..
  19. Human Salty and Bitter Taste Mechanisms
    MARION FRANK; Fiscal Year: 2007
    ..Greater understanding of gustatory perceptual processing in humans may lead to better management of taste disorders such as distressful salty-bitter dysgeusias and excessive salt intake. ..
  20. Brain Fatty Acid Composition and PKC Activity
    Robert McNamara; Fiscal Year: 2007
    ..The proposed experiments are innovative and exploratory in that the effect of altered DHA concentrations on PKC and dopamine D2 receptor expression have not been systematically examined in brain. [unreadable] [unreadable] [unreadable]..
  21. Taste Quality Coding Of Salts
    STEVEN ST JOHN; Fiscal Year: 2004
    ....
  22. Controlled Study of SAMe vs.Escitalopram in Major Depressive Disorder
    Maurizio Fava; Fiscal Year: 2008
    ..Secondary aims are to assess the acute effects of SAMe or escitalopram vs. placebo on remission rates, quality of life, and psychosocial functioning. ..
  23. Omega-3 Fatty Acid Deficient Rat Model of Schizophrenia
    Robert McNamara; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  24. Role of Cyclooxygenase stimulated Neovascularization in Diabetic Nephropathy
    Chuan Ming Hao; Fiscal Year: 2008
    ..Pozzi's expertise in angiogenesis and Dr. Breyer's expertise in mouse models of diabetic nephropathy, and draws on their common interest in the prostanoid pathway in cell differentiation and survival. ..
  25. Rapid DA-Acb signaling in ingestive behaviors
    MITCHELL ROITMAN; Fiscal Year: 2008
    ..These studies will establish the range of natural stimuli that promote rapid DA-Acb signaling - setting the foundation for examining aberrant signaling underlying drug addiction. [unreadable] [unreadable] [unreadable] [unreadable]..
  26. Renal Medullary COX2 in Blood Pressure Regulation
    Chuan Ming Hao; Fiscal Year: 2009
    ..Specific Aim III: To define the down-stream target of activated renal medullary COX2 expression. ..
  27. Neuroscience Center for Biomedical Research Excellence
    Francis W Flynn; Fiscal Year: 2010
    ....
  28. tPA plus MMP inhibition for combination stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..abstract_text> ..
  29. LIPID METABOLISM IN FAT CELLS
    Wen Guo; Fiscal Year: 2010
    ..Together, these studies will provide new insights into the stress-induced regulation of lipogenesis in adipocytes, a potentially important avenue for modulating energy balance. ..
  30. CD47 as a neurovascular target for stroke therapy
    Eng H Lo; Fiscal Year: 2010
    ..Proof-of-concept data collected here may lead to the development of CD47 as a novel neurovascular target for stroke therapy. ..
  31. Neuropharmacology of Learned Food Preferences
    Anthony Sclafani; Fiscal Year: 2009
    ..It will advance our understanding of the basic mechanisms involved in the development of food preferences and may provide insights into the clinical treatment of overeating and obesity. ..
  32. BIPOLAR DISORDER IN LATE LIFE
    John Beyer; Fiscal Year: 2009
    ..This research is unique and is likely to enhance our understanding of the phenomenology, course, outcome and relationship of MRI changes to the pathophysiology of bipolar disorder in late life. ..
  33. Is ethanol rewarding or aversive?
    Chuang Liu; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  34. Glucogen Synthase Kinase 3beta and Bipolar Disorder
    Xiaohua Li; Fiscal Year: 2007
    ....
  35. MOLECULAR PHARMACOLOGY OF VOLTAGE SENSITIVE NA CHANNELS
    Edward Moczydlowski; Fiscal Year: 2001
    ..These biophysical studies will allow us deduce the functional contribution of key residues that determine ionic selectivity and unitary conductance of the NaV channel pore. ..
  36. White Matter Abnormalities in Bipolar Adolescents
    Vivian Kafantaris; Fiscal Year: 2005
    ..Recruitment for this proposed study will be facilitated by the PI's ongoing NIMH-funded longitudinal treatment study of bipolar adolescents. ..
  37. Interstitial Cell COXs in Renal Development and Disease
    Chuan Ming Hao; Fiscal Year: 2004
    ....
  38. TRANSCRIPTIONAL REGULATORS OF CHONDROINDUCTION BY DBP
    Karen Yates; Fiscal Year: 2004
    ..We will determine which DBP-regulated transcription factors are necessary and/or sufficient for postnatal chondrogenesis. This proposed work would have a high impact of design of strategies for repair and/or regeneration of cartilage. ..
  39. Murine Model of Marijuana-Induced Executive Dysfunction
    RUTH COLWILL; Fiscal Year: 2003
    ..Changes in endocannabinoid levels: -Measurements of anandamide and 2-arachidonylglycerol in dissected brain regions using liquid chromatography/mass spectrometry (LC/MS). ..
  40. SEX STEROID REGULATION OF IGF-I EXPRESSION IN BONE
    Thomas McCarthy; Fiscal Year: 2003
    ..Bone mass studies will be conducted using peripheral quantitative computer tomography, and will be correlated with basal and activated skeletal IGF-I expression. ..
  41. BUPROPION AS AN ADJUNCT TO THE NICOTINE PATCH PLUS CBT
    Maurizio Fava; Fiscal Year: 2003
    ....
  42. ECT IN CLOZAPINE REFRACTORY SCHIZOPHRENIA
    Georgios Petrides; Fiscal Year: 2003
    ..The results of the study will guide clinicians faced with the problem of how to treat patients who have not been helped by standard antipsychotic medications and do not show an adequate response to clozapine. ..
  43. EXTINCTION AND RECOVERY OF CONDITIONED AVERSIONS
    Todd Schachtman; Fiscal Year: 2001
    ....
  44. Regulation of GSK3beta by Mood Stabilizers
    Xiaohua Li; Fiscal Year: 2005
    ..The data obtained from this proposal will be used to support a future R01 grant application to achieve our long-term goal of understanding the pathophysiology and improving the treatment of bipolar disorder. ..
  45. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Georgios Petrides; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  46. MECHANISMS OF HEMORRHAGE AND EDEMA IN TPA STROKE THERAPY
    ENG LO; Fiscal Year: 2006
    ..This proposal should fit the goals of the Stroke PRG because it examines novel mechanisms that link tPA, cell signaling, MMPs, and hemorrhagic transformation in the neurovascular unit. ..
  47. Society for the Stimulus Properties of Drugs Satellite
    Ellen Walker; Fiscal Year: 2005
    ..The SSPD Satellite to the EBPS 2005 Conference promises to coordinate, exchange, and disseminate information to further our understanding of drug abuse. ..
  48. Stepped Pharmacotherapy for Aggressive Youth with ADHD
    JOSEPH BLADER; Fiscal Year: 2006
    ..The proposed program will therefore culminate in the awardee's competence as a well-rounded clinical scientist focused on the complex treatment needs of youth with severe behavior disorders. ..
  49. SCHIFF BASE SYNTHONS IN AMINO ACID CHEMISTRY
    MARTIN O DONNELL; Fiscal Year: 2006
    ..A key point of focus in this research will be to continue to develop practical and easy-to-use methods that can lead to potential drugs. ..
  50. NEUROPEPTIDES AND SALT APPETITE
    FRANCIS FLYNN; Fiscal Year: 2007
    ..Successful completion of the proposed work will expand the knowledge base on brain mechanisms controlling bodily fluid homeostasis. ..
  51. WNT PROTEINS IN ADULT, AGED AND OSTEOARTHRITIC CARTILAGE
    Karen Yates; Fiscal Year: 2005
    ..This work will also provide a solid foundation for future research on Wnts in cartilage biology. ..
  52. Role of amygdala systems in associative learning
    Peter Holland; Fiscal Year: 2005
    ..abstract_text> ..
  53. Associatively-activated event representations
    Peter Holland; Fiscal Year: 2006
    ..The proposed research provides a basis for the understanding of basic processing of imaginal events in associative learning. ..
  54. BRAIN CELL APOPTOSIS AFTER INTRACEREBRAL HEMORRHAGE
    ENG LO; Fiscal Year: 2003
    ..Results may be used to improve the clinical management and treatment of intracerebral hemorrhage. ..
  55. Development of viscerosensory neural inputs in rat brain
    Thomas Koehnle; Fiscal Year: 2006
    ..The experimental outcomes will significantly enhance our understanding of how these pathways mature, and how they operate in health and disease. [unreadable] [unreadable] [unreadable]..
  56. MOLECULAR MECHANISMS OF CONDITIONED TASTE AVERSION
    THOMAS HOUPT; Fiscal Year: 2004
    ..correlate of the expression of a CTA previously acquired by pairing intraoral infusions of sucrose with lithium chloride. We hypothesize that cFos expression reveals functionally important brain sites mediating CTA, and that the ..
  57. Matrix metalloproteinase-9 mediated cell death in stroke
    ENG LO; Fiscal Year: 2009
    ..Our lab and others have established MMP-9 as a key extracellular protease that modifies neurovascular homeostasis. These proposed studies should help reveal the mechanisms of MMP-9 mediated cell death in stroke. ..
  58. Reward comparison, drugs of abuse & the gustatory cortex
    RASTAFA GEDDES; Fiscal Year: 2004
    ..Finally, Specific Aim III will determine whether an intact gustatory cortex is essential for retention of a preoperatively acquired association between the saccharin CS and the drug. ..
  59. MATRIX METALLOPROTEINASE AND APOPTOSIS IN BRAIN TRAUMA
    ENG LO; Fiscal Year: 2004
    ..To date, there are not effective treatments for traumatic brain injury. Results from these proposed experiments will help identify MMP and upstream MAP kinase pathways as viable therapeutic targets for this devastating condition. ..
  60. US Specific and General Processes in Pavlovian Learning
    ANDREW DELAMATER; Fiscal Year: 2006
    ..More globally, it is hoped that these studies will provide a much firmer basis upon which to think about the cognitive and motivational foundations of learning. ..
  61. GSK3: Neural Modulators and Mood Disorders
    Xiaohua Li; Fiscal Year: 2009
    ..This research is expected to provide significant new insight into the pathophysiology and the treatment of mood disorders. ..
  62. Epileptogenicity in the Developing Brain
    Raman Sankar; Fiscal Year: 2007
    ..Our findings will provide the basis for future neuroprotective interventions targeting the developing brain at different stages of status epilepticus in order to interrupt the course of the epileptogenic process. ..