lithium carbonate

Summary

Summary: A lithium salt, classified as a mood-stabilizing agent. Lithium ion alters the metabolism of BIOGENIC MONOAMINES in the CENTRAL NERVOUS SYSTEM, and affects multiple neurotransmission systems.

Top Publications

  1. ncbi A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder
    Andrew McQuillin
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    Pharmacogenet Genomics 17:605-17. 2007
  2. ncbi Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
    Chiara Pizzasegola
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Amyotroph Lateral Scler 10:221-8. 2009
  3. ncbi Therapeutic effects of valproate combined with lithium carbonate on MPTP-induced parkinsonism in mice: possible mediation through enhanced autophagy
    Xue Zhong Li
    Department of Neurology, Jiangsu University Affiliated People s Hospital, Jiangsu, China
    Int J Neurosci 123:73-9. 2013
  4. ncbi Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, Detroit, MI 48201, USA
    Bipolar Disord 2:217-36. 2000
  5. ncbi A clinician's guide to monitoring kidney function in lithium-treated patients
    James W Jefferson
    Department of Psychiatry, Healthcare Technology Systems, Inc, 7617 Mineral Point Rd, Ste 300, Madison, WI 53717, USA
    J Clin Psychiatry 71:1153-7. 2010
  6. ncbi Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review
    Ross J Baldessarini
    International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:625-39. 2006
  7. ncbi Formulation of sustained - release lithium carbonate matrix tablets: influence of hydrophilic materials on the release rate and in vitro-in vivo evaluation
    Jaber Emami
    Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    J Pharm Pharm Sci 7:338-44. 2004
  8. ncbi Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trial
    Sidney H Kennedy
    University of Toronto, The University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 64:439-44. 2003
  9. ncbi Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder
    Sara Campos-de-Sousa
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Biol Rhythms 25:132-7. 2010
  10. ncbi Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis
    Jin Hee Shin
    Department of Pharmacology, Ajou University School of Medicine, Sawon, Korea 442 749
    Mol Pharmacol 71:965-75. 2007

Detail Information

Publications236 found, 100 shown here

  1. ncbi A microarray gene expression study of the molecular pharmacology of lithium carbonate on mouse brain mRNA to understand the neurobiology of mood stabilization and treatment of bipolar affective disorder
    Andrew McQuillin
    Molecular Psychiatry Laboratory, Department of Mental Health Sciences, Windeyer Institute of Medical Sciences, Royal Free and University College Medical School, London, UK
    Pharmacogenet Genomics 17:605-17. 2007
    ..To understand how lithium produces changes in the brain, we studied brain mRNA from 10 mice after treatment with lithium and compared them with 10 untreated controls...
  2. ncbi Treatment with lithium carbonate does not improve disease progression in two different strains of SOD1 mutant mice
    Chiara Pizzasegola
    Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy
    Amyotroph Lateral Scler 10:221-8. 2009
    It has been shown that chronic treatment with lithium carbonate (Li(2)CO(3)) in presymptomatic SOD1G93A transgenic male mice, a model of ALS, was able to remarkably increase their lifespan through the activation of autophagy and the ..
  3. ncbi Therapeutic effects of valproate combined with lithium carbonate on MPTP-induced parkinsonism in mice: possible mediation through enhanced autophagy
    Xue Zhong Li
    Department of Neurology, Jiangsu University Affiliated People s Hospital, Jiangsu, China
    Int J Neurosci 123:73-9. 2013
    In order to investigate the mechanisms and therapeutic effects of valproate combined with lithium carbonate on mouse model of Parkinson's disease (PD), male C57BL/6 mice were injected into intraperitoneal with valproate (20 μg/ml) ..
  4. ncbi Lithium regulates PKC-mediated intracellular cross-talk and gene expression in the CNS in vivo
    G Chen
    Department of Psychiatry and Behavioral Neurosciences, WSU School of Medicine, Detroit, MI 48201, USA
    Bipolar Disord 2:217-36. 2000
    ..Together, these results suggest that the PKC signaling pathway and PKC-mediated gene expression may be important mediators of lithium's long-term therapeutic effects in a disorder as complex as BD...
  5. ncbi A clinician's guide to monitoring kidney function in lithium-treated patients
    James W Jefferson
    Department of Psychiatry, Healthcare Technology Systems, Inc, 7617 Mineral Point Rd, Ste 300, Madison, WI 53717, USA
    J Clin Psychiatry 71:1153-7. 2010
    ..This overview clarifies those practical aspects of monitoring that are often overlooked or misunderstood...
  6. ncbi Decreased risk of suicides and attempts during long-term lithium treatment: a meta-analytic review
    Ross J Baldessarini
    International Consortium for Research on Bipolar Disorders, Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Bipolar Disord 8:625-39. 2006
    ..To update and extend comparisons of rates of suicides and suicide attempts among patients with major affective disorders with versus without long-term lithium treatment...
  7. ncbi Formulation of sustained - release lithium carbonate matrix tablets: influence of hydrophilic materials on the release rate and in vitro-in vivo evaluation
    Jaber Emami
    Department of Pharmaceutics, Faculty of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran
    J Pharm Pharm Sci 7:338-44. 2004
    Conventional lithium carbonate (LC) tablets not only produce rapid and relatively high peak blood levels resulting in adverse effects but also should be administered 3 to 4 times daily...
  8. ncbi Lithium carbonate versus cognitive therapy as sequential combination treatment strategies in partial responders to antidepressant medication: an exploratory trial
    Sidney H Kennedy
    University of Toronto, The University Health Network, Toronto, Ontario, Canada
    J Clin Psychiatry 64:439-44. 2003
    ..Despite increasing evidence that full symptomatic remission is the optimal goal of antidepressant therapy, there have been few comparisons between disparate treatment approaches to achieve this goal...
  9. ncbi Nuclear receptor rev-erb-{alpha} circadian gene variants and lithium carbonate prophylaxis in bipolar affective disorder
    Sara Campos-de-Sousa
    MRC Social Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, King s College London, UK
    J Biol Rhythms 25:132-7. 2010
    ..investigated whether polymorphisms in the Rev-erb- alpha gene are associated with the long-term efficacy of lithium carbonate therapy in bipolar affective disorder...
  10. ncbi Concurrent administration of Neu2000 and lithium produces marked improvement of motor neuron survival, motor function, and mortality in a mouse model of amyotrophic lateral sclerosis
    Jin Hee Shin
    Department of Pharmacology, Ajou University School of Medicine, Sawon, Korea 442 749
    Mol Pharmacol 71:965-75. 2007
    ..Administration of lithium carbonate (Li(+)), a mood stabilizer that prevents apoptosis, blocked the apoptosis machinery without preventing ..
  11. ncbi Lithium carbonate in amyotrophic lateral sclerosis: lack of efficacy in a dose-finding trial
    A Chio
    Department of Neuroscience, Via Cherasco 15, 10126 Torino, Italy
    Neurology 75:619-25. 2010
    ..We performed a multicenter trial with lithium carbonate to assess its tolerability, safety, and efficacy in patients with ALS, comparing 2 different target blood ..
  12. ncbi Depressive relapse during lithium treatment associated with increased serum thyroid-stimulating hormone: results from two placebo-controlled bipolar I maintenance studies
    M A Frye
    Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA
    Acta Psychiatr Scand 120:10-3. 2009
    ..To assess the relationship between depressive relapse and change in thyroid function in an exploratory post hoc analysis from a controlled maintenance evaluation of bipolar I disorder...
  13. ncbi Adherence to lithium in naturalistic settings: results from a nationwide pharmacoepidemiological study
    Lars Vedel Kessing
    Department of Psychiatry, University Hospital of Copenhagen, Rigshospitalet, University of Copenhagen, Denmark
    Bipolar Disord 9:730-6. 2007
    ..To estimate adherence to lithium in a nationwide sample of all patients treated with lithium and to characterize adherence according to gender and age...
  14. ncbi Two peptidase activities decrease in treated bipolar disorder not schizophrenic patients
    Gerome Breen
    Section of Molecular Genetics, Division of Psychological Medicine, Institute of Psychiatry, Kings College London, London, UK
    Bipolar Disord 6:156-61. 2004
    ..However, this association is complicated by the discovery in bovine plasma of a Z-Pro-prolinal-insensitive peptidase (ZIP), a novel enzyme that cleaves the same substrate as PO...
  15. pmc No association between the PREP gene and lithium responsive bipolar disorder
    Firoza Mamdani
    Douglas Hospital Research Centre, McGill University, Montreal, Quebec, Canada
    BMC Psychiatry 7:9. 2007
    ....
  16. ncbi The use of lithium carbonate in the preparation for definitive therapy in hyperthyroid patients
    Fulya Akin
    Department of Endocrinology and Metabolic Diseases, School of Medicine, Pamukkale University, Denizli, Turkey
    Med Princ Pract 17:167-70. 2008
    The aim of this study was to elucidate the effectiveness of lithium carbonate prior to thyroidectomy or radioiodide therapy in patients with thyrotoxicosis.
  17. pmc Glycogen synthase kinase-3beta, mood stabilizers, and neuroprotection
    Xiaohua Li
    Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, 35294 0017, USA
    Bipolar Disord 4:137-44. 2002
    ....
  18. ncbi Association between consistent purchase of anticonvulsants or lithium and suicide risk: a longitudinal cohort study from Denmark, 1995-2001
    Eric G Smith
    Center for Psychopharmacologic Research and Treatment, Department of Psychiatry, University of Massachusetts Medical School, Worcester, MA 01605, USA 610041
    J Affect Disord 117:162-7. 2009
    ..Prior studies suggest anticonvulsants purchasers may be at greater risk of suicide than lithium purchasers...
  19. ncbi Lithium plus valproate combination therapy versus monotherapy for relapse prevention in bipolar I disorder (BALANCE): a randomised open-label trial
    John R Geddes
    Oxford Clinical Trials Unit for Mental Illness, Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford OX3 7JX, UK
    Lancet 375:385-95. 2010
    b>Lithium carbonate and valproate semisodium are both recommended as monotherapy for prevention of relapse in bipolar disorder, but are not individually fully effective in many patients...
  20. pmc Adjunctive use of lithium carbonate for the management of neutropenia in clozapine-treated children
    Anand Mattai
    Child Psychiatry Branch, NIMH, NIH, MD 20892 1600, USA
    Hum Psychopharmacol 24:584-9. 2009
    ..In children, the rate of neutropenia is higher when compared to adults. We decided to explore the use of lithium to manage neutropenia in childhood-onset schizophrenia (COS) through a systematic audit of COS cases...
  21. ncbi The Bipolar Comprehensive Outcomes Study (BCOS): baseline findings of an Australian cohort study
    Jayashri Kulkarni
    Alfred Psychiatry Research Centre, The Alfred and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Commercial Road, Melbourne VIC 3004, Australia
    J Affect Disord 107:135-44. 2008
    ..The Bipolar Comprehensive Outcomes Study (BCOS) is a 2-year, observational study of participants with bipolar I or schizoaffective disorder examining clinical, functional, and economic outcomes associated with naturalistic treatment...
  22. ncbi A lithium clinic for bipolar patients: 2-year outcome of the first 148 patients
    R W Licht
    Mood Disorders Research Unit, Aarhus University Psychiatric Hospital, Skovagervej 2, DK-8240 Risskov, Denmark
    Acta Psychiatr Scand 104:387-90. 2001
    ..Better long-term treatment results for bipolar patients depend on both the development of more effective mood stabilizing drugs or drug combinations and the improvement of patients' adherence to treatment...
  23. ncbi Effects of lithium carbonate (Li2CO3) on in-vitro-cultured normal human skin explants
    R Wolf
    The Macabbi Health Care Outpatient Clinic, and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    J Eur Acad Dermatol Venereol 14:97-9. 2000
    The early morphological changes induced by lithium carbonate, a well-known psoriasis-provoking drug, were studied on cultured skin...
  24. pmc Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis: examining a more efficient trial design
    R G Miller
    California Pacific Medical Center, San Francisco, CA, USA
    Neurology 77:973-9. 2011
    To use a historical placebo control design to determine whether lithium carbonate slows progression of amyotrophic lateral sclerosis (ALS).
  25. ncbi [Development of sustained vasodilatory shock and permanent loss of hearing after severe lithium carbonate poisoning]
    Ulla Plenge
    Burmeistersgade 21, 3 tv, DK 1429 København K
    Ugeskr Laeger 170:354. 2008
    A case of severe lithium carbonate self-poisoning is described, presenting with sustained vasodilatory shock, DIC and neurologic manifestations...
  26. ncbi Lithium in mood disorders: increasing evidence base, declining use?
    Allan H Young
    Institute of Mental Health, University of British Columbia, University Boulevard, Vancouver, British Columbia, Canada V6T 1Z3
    Br J Psychiatry 191:474-6. 2007
    ..Recent meta-analyses confirm the benefits of maintenance lithium treatment and show that it reduces suicide and suicidality. Psychiatrists should continue to utilise this efficacious treatment for bipolar disorder...
  27. ncbi Neuroprotective effects of lithium in cultured cells and animal models of diseases
    De Maw Chuang
    Section on Molecular Neurobiology, Mood and Anxiety Disorder Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1363, USA
    Bipolar Disord 4:129-36. 2002
    ..Our results suggest that lithium might have utility in the treatment of neurodegenerative disorders in addition to its common use for the treatment of bipolar depressive patients...
  28. ncbi Non-adherence with long-term prophylaxis: a 6-year naturalistic follow-up study of affectively ill patients
    C Schumann
    Department of Psychiatry, University of Vienna, Austria
    Psychiatry Res 89:247-57. 1999
    ..Our findings confirmed non-adherence as a major problem in the effectiveness of lithium prophylaxis. The authors recommend prospective investigations of attitudes and the impact of psychoeducation on long-term adherence...
  29. ncbi Case-control analyses of the impact of pharmacotherapy on prospectively observed suicide attempts and completed suicides in bipolar disorder: findings from STEP-BD
    Lauren B Marangell
    Mood Disorders Center, Menninger Department of Psychiatry, Baylor College of Medicine and South Central Mental Illness Research and Education Core, Department of Veterans Affairs, Houston, Tex, USA
    J Clin Psychiatry 69:916-22. 2008
    ....
  30. pmc Lithium therapy improves neurological function and hippocampal dendritic arborization in a spinocerebellar ataxia type 1 mouse model
    Kei Watase
    21st Century COE program on Brain Integration and Its Disorders, Tokyo Medical and Dental University, Tokyo, Japan
    PLoS Med 4:e182. 2007
    ....
  31. ncbi Mood-stabilizers: the archeology of the concept
    Margaret Harris
    North Wales Department of Psychological Medicine, Hergest Unit, Bangor, UK
    Bipolar Disord 5:446-52. 2003
    ..To review the history of 'mood-stabilizing' treatments...
  32. ncbi Antidepressants in bipolar disorder: the case for caution
    S Nassir Ghaemi
    Bipolar Disorder Research Program, Cambridge Hospital, Cambridge, MA and Harvard Medical School, Boston, MA 02139, USA
    Bipolar Disord 5:421-33. 2003
    ....
  33. ncbi A placebo-controlled 18-month trial of lamotrigine and lithium maintenance treatment in recently depressed patients with bipolar I disorder
    Joseph R Calabrese
    University Hospitals of Cleveland Case Western Reserve School of Medicine, Department of Psychiatry, 11400 Euclid Ave, Ste 200, Cleveland, OH 44106, USA
    J Clin Psychiatry 64:1013-24. 2003
    ..This study assessed the efficacy and tolerability of lamotrigine and lithium compared with placebo for the prevention of mood episodes in bipolar disorder...
  34. ncbi Efficacy of olanzapine combined with valproate or lithium in the treatment of dysphoric mania
    Robert W Baker
    Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, IN 46285, USA
    Br J Psychiatry 185:472-8. 2004
    ..Few controlled studies examine the treatment of depressive features in mania...
  35. ncbi Treatment considerations for patients experiencing rapid-cycling bipolar disorder
    Deborah Antai-Otong
    Perspect Psychiatr Care 42:55-8. 2006
  36. ncbi Alternatives to lithium and divalproex in the maintenance treatment of bipolar disorder
    Mukund Gnanadesikan
    Department of Psychiatry, University of Arizona, Tuscon 85724, USA
    Bipolar Disord 5:203-16. 2003
    The role of lithium carbonate in the maintenance treatment of bipolar disorder is well established. Unfortunately, many patients fail to respond adequately to this agent or are unable to tolerate its adverse effects...
  37. ncbi A retrospective analysis of changing from alternative agents to carbamazepine extended-release capsules in bipolar disorder
    Lawrence D Ginsberg
    Red Oak Psychiatry Associates, Houston, TX 77090, USA
    Ann Clin Psychiatry 18:31-4. 2006
    ..Patients with bipolar disorder do not respond to the same therapy in the same way. This potentially necessitates the trial of various treatment modalities in a patient until the illness can be successfully controlled...
  38. ncbi Combination lithium and divalproex sodium in pediatric bipolarity
    Robert L Findling
    Department of Psychiatry, Case Western Reserve University School of Medicine, USA
    J Am Acad Child Adolesc Psychiatry 42:895-901. 2003
    b>Lithium carbonate (Li) or divalproex sodium (DVPX) may be effective for some juveniles with bipolar disorder. Many youths with bipolar disorder do not respond to DVPX or Li monotherapy...
  39. ncbi Challenges in the diagnosis & treatment of bipolar depression--part 2: treatment options
    Robert H Howland
    University of Pittsburgh School of Medicine, Western Psychiatric Institute and Clinic, Pennsylvania 15213, USA
    J Psychosoc Nurs Ment Health Serv 44:9-12. 2006
  40. ncbi The role of the extracellular signal-regulated kinase signaling pathway in mood modulation
    Haim Einat
    Laboratory of Molecular Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892 4405, USA
    J Neurosci 23:7311-6. 2003
    ..These data suggest that the ERK pathway may mediate the antimanic effects of mood stabilizers...
  41. ncbi Quetiapine for mania with Wilson's disease
    Isin Baral Kulaksizoglu
    Psychosomatics 44:438-9. 2003
  42. ncbi [Prophylaxis of bipolar disorder]
    Andrea Sterr
    Psychiatrische Universitätsklinik der LMU München
    Psychiatr Prax 33:S47-54. 2006
    ..This article summarises the current state of knowledge on treatment options for maintenance therapy...
  43. ncbi [Differential diagnosis and pharmacotherapy of juvenile mania -- a review]
    Hellmuth Braun-Scharm
    Klinik fur Kinder und Jugendpsychiatrie und psychotherapie, Vivantes Humboldt Klinikum, Berlin
    Psychiatr Prax 33:S40-6. 2006
    ..Adequate medication and psychotherapy in the early phases of these chronic disorders ameliorate the overall prognosis. Special attention should be drawn to hypomanic phases and phenomena as rapid cycling...
  44. ncbi Priapism associated with oxcarbazepine, aripiprazole, and lithium
    Brett Negin
    J Am Acad Child Adolesc Psychiatry 44:1223-4. 2005
  45. ncbi Separate and concomitant use of lamotrigine, lithium, and divalproex in bipolar disorders
    Daniel Z Lieberman
    Department of Psychiatry and Behavioral Sciences, George Washington University, 2150 Pennsylvania Ave, NW, Washington, DC 20037, USA
    Curr Psychiatry Rep 6:459-65. 2004
    ..Because no agent is universally effective in all phases of the illness, combination therapy with two or more agents often is the best option...
  46. ncbi Effect of risperidone on prolactinoma--a case report
    D N Mendhekar
    Pharmacopsychiatry 37:41-2. 2004
    ..Further study is recommended to find out relationship between the growth of prolactinoma and risperidone...
  47. ncbi Outcome measurement, outcome management and monitoring
    Gavin Andrews
    School of Psychiatry, University of New South Wales at St Vincent s Hospital, Sydney, Australia
    Aust N Z J Psychiatry 39:649-51. 2005
  48. ncbi Do recent efficacy data on the drug treatment of acute bipolar depression support the position that drugs other than antidepressants are the treatment of choice? A conceptual review
    Hans Jurgen Moller
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    Eur Arch Psychiatry Clin Neurosci 256:1-16. 2006
    ..In addition the regulatory requirements for licensing a drug for the indication "short-term treatment of bipolar depression" are described...
  49. ncbi Rethinking the treatment paradigm for bipolar depression: the importance of long-term management
    Claudia F Baldassano
    Department of Psychiatry, University of Pennsylvania Medical Center, Philadelphia, PA 19104, USA
    CNS Spectr 9:11-8. 2004
    ..To date, three agents--lithium, lamotrigine, and olanzapine--have been shown to have prophylactic benefits in treating this highly recurrent disorder...
  50. ncbi Management of bipolar disorder during pregnancy and the postpartum period
    Kimberly A Yonkers
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Psychiatry 161:608-20. 2004
    ..The authors summarize knowledge regarding the management of bipolar disorder during pregnancy and the postpartum period, with a focus on managing mania, hypomania, and the psychotic components of the illness...
  51. ncbi Longitudinal evaluation of reproductive function in women treated for bipolar disorder
    Natalie L Rasgon
    Department of Psychiatry and Behavioral Sciences, Stanford School of Medicine, Stanford University, 401 Quarry Road, Palo Alto, Ca 94305 5723 Stanford, California, United States
    J Affect Disord 89:217-25. 2005
    ..We assessed reproductive endocrine and metabolic markers in women treated for bipolar disorder over a 2-year time period, controlling for valproate use...
  52. ncbi [Bipolar disorders--how to recognize and treat them]
    H Grunze
    Klinik und Poliklinik fur Psychiatrie, LMU Munchen
    MMW Fortschr Med 146:4-6, 8. 2004
    ..The subsequent relapse prophylaxis depends on effectiveness, tolerability, comorbidity, suicidal risk and compliance. Pharmacotherapy is supplemented by psychotherapy and psycho-education...
  53. ncbi Initial symptoms of manic relapse in manic or mixed-manic bipolar disorder: post hoc analysis of patients treated with olanzapine or lithium
    John P Houston
    Lilly Corporate Center, Lilly Research Laboratories, Drop Code 4133, Indianapolis, IN 46285, United States
    J Psychiatr Res 41:616-21. 2007
    ....
  54. ncbi Mood stabilizer augmentation in apparently "unipolar" MDD: predictors of response in the naturalistic French national EPIDEP study
    Elie G Hantouche
    Department of Psychiatry, Adult Psychiatry, Mood Center, Consultation de l Humeur, Pitie Salpetriere Hospital, 47 bd de l Hopital, 75013 Paris, France
    J Affect Disord 84:243-9. 2005
    ....
  55. ncbi Oxcarbazepine as add-on treatment in patients with bipolar manic, mixed or depressive episode
    Alessandra Benedetti
    Department of Psychiatry, Neurobiology, Pharmacology and Biotechnology, University of Pisa, Pisa, Italy
    J Affect Disord 79:273-7. 2004
    ..The aim of this preliminary open-label trial was to evaluate the efficacy and safety of oxcarbazepine (OXC) as adjunctive therapy in 18 patients with bipolar disorder who did not respond satisfactorily to lithium...
  56. ncbi Pharmacological management of new-onset bipolar disorder
    Christopher J Kratochvil
    Department of Psychiatry, University of Nebraska Medical Center, Omaha, NE 68198 5581, USA
    J Am Acad Child Adolesc Psychiatry 44:1198-200. 2005
  57. ncbi Subjective life satisfaction and objective functional outcome in bipolar and unipolar mood disorders: a longitudinal analysis
    Joseph F Goldberg
    Affective Disorders Program, Silver Hill Hospital, New Canaan, CT 06840, USA
    J Affect Disord 89:79-89. 2005
    ..The goal of the present study was to examine the longitudinal associations between subjective life satisfaction and objective functional outcome among individuals with bipolar and unipolar mood disorders...
  58. ncbi Mania during treatment of chronic hepatitis C with pegylated interferon and ribavirin
    Chiadi U Onyike
    Department of Psychiatry and Behavioral Sciences, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA
    Am J Psychiatry 161:429-35. 2004
  59. ncbi [Efficacy of depakine chrono and lithium combination in the treatment of manic states]
    N A Aliev
    Zh Nevrol Psikhiatr Im S S Korsakova 103:49-50. 2003
  60. ncbi Treatment of bipolar depression
    Steven L Dubovsky
    Department of Psychiatry, State University of New York at Buffalo, 462 Grider Street, Buffalo, NY 14215, USA
    Psychiatr Clin North Am 28:349-70, vii. 2005
    ..Considering the limitations of current knowledge is an essential component of the scientific practice of psychiatry...
  61. ncbi Preliminary study of relationships among measures of depressive symptoms in adolescents with bipolar disorder
    Nick C Patel
    College of Pharmacy, Department of Psychiatry, University of Cincinnati College of Medicine, 3225 Eden Avenue, Cincinnati, OH 45267, USA
    J Child Adolesc Psychopharmacol 16:327-35. 2006
    ..We hypothesized that CDRS-R and HAM-D scores would be significantly correlated and both scales would be sensitive to change resulting from treatment...
  62. ncbi Olanzapine monotherapy and olanzapine combination therapy in the treatment of mania: 12-week results from the European Mania in Bipolar Longitudinal Evaluation of Medication (EMBLEM) observational study
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona IDIBAPS, Barcelona, Spain
    J Affect Disord 106:63-72. 2008
    ....
  63. ncbi Efficacy of olanzapine in combination with valproate or lithium in the treatment of mania in patients partially nonresponsive to valproate or lithium monotherapy
    Mauricio Tohen
    Lilly Research Laboratories, Eli Lilly and Co, Indianapolis, IN 46285, USA
    Arch Gen Psychiatry 59:62-9. 2002
    ....
  64. ncbi Bipolar pharmacotherapy and suicidal behavior Part 3: impact of antipsychotics
    Boghos I Yerevanian
    Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles 10111 Plummer Street, North Hills, CA 91343, United States
    J Affect Disord 103:23-8. 2007
    ..Antipsychotics, particularly second generation agents, are widely used in bipolar disorder, but their effect on suicidal behavior in this population has not been systematically studied...
  65. ncbi Long-term naturalistic treatment of depressive symptoms in bipolar illness with divalproex vs. lithium in the setting of minimal antidepressant use
    S N Ghaemi
    Psychopharmacology Program, Cambridge Hospital, Consolidated Department of Psychiatry, Harvard Medical School, Cambridge, MA, USA
    J Affect Disord 65:281-7. 2001
    ..Both agents, but particularly divalproex, demonstrated long-term antidepressant effects, with limited adjunctive standard antidepressant use...
  66. ncbi [Hypernatremia as a rare complication in change from lithium to valproate]
    K Berendes
    Westliche 301, 75172 Pforzheim
    Nervenarzt 72:555-7. 2001
    ..This hypernatremia was due to renal diabetes insipidus stemming from the decades of lithium therapy, with accompanying polydipsia and polyuria, and also to the failure to give enough fluid to the somnolent patient...
  67. ncbi Clinical inquiries. What's the best strategy for bipolar disorder during pregnancy?
    Genevieve Minick
    Guthrie Family Medicine Residency, Sayre, PA, USA
    J Fam Pract 56:665-8. 2007
  68. ncbi Treatments in child and adolescent bipolar disorders
    Angèle Consoli
    Department of Child and Adolescent Psychiatry, Universite Pierre et Marie Curie, Hopital Pitie Salpetriere, AP HP, 47 Boulevard de l Hopital, 75013, Paris, France
    Eur Child Adolesc Psychiatry 16:187-98. 2007
    ....
  69. ncbi Bipolar II disorder: arguments for and against a distinct diagnostic entity
    Eduard Vieta
    Bipolar Disorders Program, Hospital Clinic, University of Barcelona, IDIBAPS, CIBER SAM, Barcelona, Spain
    Bipolar Disord 10:163-78. 2008
    ..As a commitment to the International Society for Bipolar Disorders (ISBD), a Task Force was developed to investigate the diagnostic value of bipolar II disorder...
  70. ncbi Quetiapine and classical mood stabilizers in the long-term treatment of Bipolar Disorder: a 4-year follow-up naturalistic study
    A C Altamura
    Department of Psychiatry, University of Milan, IRCCS Fondazione Ospedale Maggiore Policlinico Mangiagalli e Regina Elena, Milan, Italy
    J Affect Disord 110:135-41. 2008
    ..The aim of this naturalistic study was to compare the effectiveness of quetiapine and classical mood stabilizers, as mono- or combination therapy, in the long-term treatment of Bipolar Disorder (BD)...
  71. doi Deconstructing a medication regimen
    Sheldon H Preskorn
    Department of Psychiatry, University of Kansas School of Medicine Wichita, USA
    J Psychiatr Pract 14:114-8. 2008
  72. ncbi Health-related quality of life in Thai bipolar disorder
    Ronnachai Kongsakon
    Department of Psychiatry, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand
    J Med Assoc Thai 91:913-8. 2008
    ..Bipolar disorder (BPD) affects both patients 'functioning and well-being. Quality of life (QoL) has gained increasing attention as an important functional outcome in BPD. The present study was conducted to assess QoL of Thai BPD patients...
  73. ncbi Prophylactic treatment response in bipolar disorder: results of a naturalistic observation study
    Julie Garnham
    Department of Psychiatry, Capital District Health Authority, Halifax, Canada
    J Affect Disord 104:185-90. 2007
    ..The objective of this study was to evaluate effectiveness of commonly used prophylactic treatments for bipolar disorder in a naturalistic setting and to explore factors associated with treatment response...
  74. ncbi Long-term pharmacological treatment of bipolar disorders
    Janusz Rybakowski
    Department of Adult Psychiatry, Poznan University of Medical Sciences, ul Szpitalna 27 33, 60 572 Poznan, Poland
    Neuro Endocrinol Lett 28:71-93. 2007
    ..Some issues connected with polypharmacy targeting optimal maintenance results are discussed. In addition, the long-term management and the role of antidepressants in treatment of non-bipolar I illness is also briefly described...
  75. ncbi Managing the ups and downs of bipolar disorder
    Kathryn Murphy
    Muskegon Community College, Muskegon, MI, USA
    Nursing 36:58-63; quiz 63-4. 2006
  76. ncbi Obesity as a correlate of outcome in patients with bipolar I disorder
    Andrea Fagiolini
    Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O Hara St, Pittsburgh, PA 15213, USA
    Am J Psychiatry 160:112-7. 2003
    ....
  77. ncbi Valproate or olanzapine add-on to lithium: an 8-week, randomized, open-label study in Italian patients with a manic relapse
    Giuseppe Maina
    Department of Neuroscience, Mood and Anxiety Disorders Unit, University of Turin, Italy
    J Affect Disord 99:247-51. 2007
    ..In our study we compared the efficacy and safety of valproate and olanzapine added to lithium in the treatment of patients experiencing breakthrough manic episodes while on lithium monotherapy...
  78. ncbi Gabapentin augmentation therapy in bipolar depression
    Po W Wang
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA 94305 5723, USA
    Bipolar Disord 4:296-301. 2002
    ..Gabapentin (GBP) may be useful in bipolar disorders, including as adjunctive therapy for bipolar depression, although controlled studies suggest inefficacy as primary treatment for mania or treatment-resistant rapid cycling...
  79. ncbi World Federation of Societies of Biological Psychiatry (WFSBP) guidelines for biological treatment of bipolar disorders. Part I: Treatment of bipolar depression
    Heinz Grunze
    Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
    World J Biol Psychiatry 3:115-24. 2002
    ..As these guidelines are intended for clinical use, the scientific evidence was not only graded, but also commented on by the experts of the task force to ensure practicability...
  80. ncbi [Monitoring mood regulating drugs in bipolar disorder]
    B Millet
    Service hospitalo universitaire de psychiatrie adulte, Centre Hospitalier Guillaume Regnier, Universite Rennes 1, France
    Encephale 32:S536-41. 2006
  81. ncbi Self-reported adherence to treatment with mood stabilizers, plasma levels, and psychiatric hospitalization
    Jan Scott
    Psychological Treatment Research, Division of Psychological Medicine, Institute of Psychiatry, DeCrespigny Park, London UK
    Am J Psychiatry 159:1927-9. 2002
    ..The authors explored the relationship of adherence to treatment with mood stabilizers (lithium, carbamazepine, and sodium valproate) and plasma levels of these drugs to future psychiatric hospitalizations...
  82. pmc Decreased protein kinase C (PKC) in platelets of pediatric bipolar patients: effect of treatment with mood stabilizing drugs
    Ghanshyam N Pandey
    University of Illinois at Chicago, Department of Psychiatry, 1601 West Taylor Street, Chicago, IL 60612, USA
    J Psychiatr Res 42:106-16. 2008
    ....
  83. ncbi Pharmacological treatment of acute mania in psychiatric in-patients between 1994 and 2004
    Marcus Wolfsperger
    Psychiatrische Privatklinik Sanatorium Kilchberg, Alte Landstrasse 70 84, 8802 Kilchberg, Switzerland
    J Affect Disord 99:9-17. 2007
    ..In a cross-section approach we investigated prescription practice in acute mania in 63 German, Swiss and Austrian hospitals between 1994 and 2004...
  84. ncbi Maintenance treatment of bipolar disorder: Applying research to clinical practice
    James C Y Chou
    Mt Sinai School of Medicine, New York, NY, USA
    J Psychiatr Pract 12:283-99. 2006
    ..Directions for future research are suggested...
  85. ncbi Current treatments and novel pharmacologic treatments for hyponatremia in congestive heart failure
    Steven R Goldsmith
    University of Minnesota Medical School, Minneapolis, Minnesota 55415, USA
    Am J Cardiol 95:14B-23B. 2005
    ..saline solution, loop diuretics, fluid restriction, and other pharmacologic agents, such as demeclocycline, lithium carbonate, and urea...
  86. ncbi Acute and preventive treatment of cluster headache and other trigeminal autonomic cephalgias
    Gennaro Bussone
    Clinical Neurosciences Department, C Besta National Neurological Institute, Milan, Italy
    Handb Clin Neurol 97:431-42. 2010
    ..Other frequently used preventives for cluster include lithium carbonate, methysergide where available, methylergonovine, clonidine, melatonin, valproate, gabapentin, topiramate, ..
  87. ncbi Monitoring of drugs with a narrow therapeutic range in ambulatory care
    Marsha A Raebel
    Clinical Research Unit, Kaiser Permanente of Colorado, PO Box 378066, Denver, CO 80237 8066, USA
    Am J Manag Care 12:268-74. 2006
    ....
  88. ncbi Precise and traceable (13)C/(12)C isotope amount ratios by multicollector ICPMS
    Rebeca Santamaria-Fernandez
    LGC, Queens Road, Teddington, Middlesex, TW11 0LY, UK
    Anal Chem 80:5963-9. 2008
    ..Corrected (13)C/(12)C ratios for NIST RM8545 (Lithium Carbonate LSVEC), NIST RM8573 (L-Glutamic Acid USGS40), NIST RM8542 (IAEA-CH6 Sucrose) and NIST RM8574 (L-Glutamic ..
  89. ncbi Effect of over-the-counter dosages of naproxen sodium and acetaminophen on plasma lithium concentrations in normal volunteers
    G M Levin
    Albany College of Pharmacy, New York 12208, USA
    J Clin Psychopharmacol 18:237-40. 1998
    ..The 3-phase study comprised the following: phase 1, lithium carbonate (300 mg every 12 hours) alone for 7 days; phase 2, lithium and either naproxen sodium (220 mg every 8 hours) ..
  90. ncbi Lithium's effects on rat liver glucose metabolism in vivo
    J E Rodriguez-Gil
    Unit of Reproduction, Autonomous University of Barcelona, Bellaterra, E 08193, Spain
    Arch Biochem Biophys 375:377-84. 2000
    Oral administration of lithium carbonate to fed-healthy rats strongly decreased liver glycogen content, despite the simultaneous activation of glycogen synthase and the inactivation of glycogen phosphorylase...
  91. ncbi Zinc improves antioxidative enzymes in red blood cells and hematology in lithium-treated rats
    Anshoo Malhotra
    Department of Biophysics, Panjab University, Chandigarh 160014, India
    Nutr Res 28:43-50. 2008
    ..Female Wistar rats received lithium in the form of lithium carbonate in diet at a dose level of 1...
  92. ncbi Baclofen in cluster headache
    R Hering-Hanit
    Department of Neurology, Meir General Hospital, Kfar Saba, and the Sackler Faculty of Medicine, Tel Aviv University, Israel
    Headache 40:48-51. 2000
    ..They are difficult to treat, and reported prophylactic therapies include ergotamine, steroids, methysergide, lithium carbonate, verapamil, valproate, capsaicin, leuprolide, clonidine, methylergonovine maleate, and melatonin...
  93. ncbi Effects of lithium carbonate on carboplatin-induced thrombocytopenia in dogs
    Amelie Leclerc
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada
    Am J Vet Res 71:555-63. 2010
    To describe the effects of lithium carbonate on thrombopoiesis in clinically normal dogs and in dogs treated with carboplatin.
  94. ncbi New agents for managing hyponatremia in hospitalized patients
    Mark A Munger
    College of Pharmacy, University of Utah, 30 South 2000 East, Room 201, Salt Lake City, UT 84112 5820, USA
    Am J Health Syst Pharm 64:253-65. 2007
    ..An overview of hyponatremia is provided, including its pathophysiology, clinical manifestations, signs and symptoms, and treatment, particularly with arginine vasopressin (AVP)-receptor antagonists...
  95. ncbi Nephrogenic diabetes insipidus persisting 57 months after cessation of lithium carbonate therapy: report of a case and review of the literature
    A F Guirguis
    Division of Endocrinology, Fairview General Hospital, Cleveland Clinic Health System, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
    Endocr Pract 6:324-8. 2000
    To illuminate the natural history of prolonged nephrogenic diabetes insipidus after discontinuation of lithium carbonate treatment and to assess the response to therapy with desmopressin acetate and triamterene-hydrochlorothiazide.
  96. ncbi Pharmacoeconomic and health outcome comparison of lithium and divalproex in a VA geriatric nursing home population: influence of drug-related morbidity on total cost of treatment
    J Conney
    University of California Los Angeles, Neuropsychiatric Institute, USA
    Am J Manag Care 5:197-204. 1999
    ..Total costs of treatment were assessed for a subset of geriatric patients receiving either lithium carbonate or divalproex sodium for agitation.
  97. ncbi Lithium and valproate treatment of pathological gambling: a randomized single-blind study
    Stefano Pallanti
    Mount Sinai School of Medicine, New York, NY, USA
    J Clin Psychiatry 63:559-64. 2002
    ..The aim of the present study was to evaluate the efficacy and safety of lithium and valproate in nonbipolar pathological gamblers...
  98. ncbi Effects of lithium on the beta-adrenergic receptor-adenylate cyclase system in rat cerebral cortical membranes
    Y Odagaki
    Department of Psychiatry and Neurology, Hokkaido University School of Medicine, Sapporo, Japan
    Jpn J Pharmacol 55:407-14. 1991
    ..Administration of lithium carbonate for 21 days decreased the maximum number of [3H]dihydroalprenolol binding sites without changing the ..
  99. ncbi Calcium channel blocker, nimodipine, for the treatment of bipolar disorder during pregnancy
    Dale R Yingling
    Department of Obstetrics and Gynecology, St John Hospital and Medical Center, Detroit, Mich 48236, USA
    Am J Obstet Gynecol 187:1711-2. 2002
    ..She also had hypothyroidism and bipolar disorder, which were treated with levothyroxine and lithium carbonate, respectively...
  100. ncbi Lithium for schizophrenia revisited: a systematic review and meta-analysis of randomized controlled trials
    Stefan Leucht
    Zucker Hillside Hospital, Glen Oaks, N Y, USA
    J Clin Psychiatry 65:177-86. 2004
    ..Clinicians frequently use lithium to augment antipsychotic medication in schizophrenia. Therefore, we undertook a systematic review and meta-analysis of the use of lithium in the treatment of schizophrenia...
  101. ncbi Efficacy of valproate maintenance in patients with bipolar disorder and alcoholism: a double-blind placebo-controlled study
    Ihsan M Salloum
    Western Psychiatric Institute and Clinic of the University of Pittsburgh Medical Center and School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15213, USA
    Arch Gen Psychiatry 62:37-45. 2005
    ..Patients with comorbid substance abuse disorders often are excluded from clinical trials. Thus, treatments targeting this high-risk clinical population are lacking...

Research Grants62

  1. Metabolic regulators in the mechanisms of caloric restriction
    Rozalyn M Anderson; Fiscal Year: 2013
    ..We will determine the extent to which GSK32 inhibition (lithium carbonate), SIRT1 activation (resveratrol) or PGC-11 activation (bezafibrate) can mimic the effect of CR on i) WAT ..
  2. Home-Based Lithium Level Testing for Bipolar Patients
    KUMAR SUBRAMANIAN; Fiscal Year: 2009
    ..whose proprietary names include Eskalith, Lithane, Lithonate, Lithobid and others, is administered as lithium carbonate and used for treatment of the bipolar disorders (BD), mania, and manic-depressive illness...
  3. Affective Neuroscience of Pediatric Bipolar Disorder
    Mani N Pavuluri; Fiscal Year: 2013
    ..1) At baseline in manic state, and (2) After 8 weeks of treatment with the prototypic mood stabilizer lithium carbonate in medicated euthymic responders and non-responders...
  4. Electrochemical Home Monitoring System for Lithium Blood Level
    LINDA A TEMPELMAN; Fiscal Year: 2012
    ..SUMMARY/ABSTRACT Electrochemical Home Monitoring System for Lithium Blood Level Lithium in the form of lithium carbonate is an important pharmacological treatment option in bipolar disorder (BD) and other conditions...
  5. PHENCYCLIDINE: A BEHAVIORAL AND NEUROCHEMICAL STUDY
    Herbert Meltzer; Fiscal Year: 1980
    ..Naloxone had no effect on PCP behaviors while lithium carbonate potentiated PCP stereotypies and ataxia...
  6. Brain Ion Homeostasis, Lithium and Bipolar Disorder.
    Fernando E Boada; Fiscal Year: 2013
    ..Among the mood stabilizing drugs used to treat BPD, Lithium Carbonate is an established treatment of first choice for different stages of the disease...
  7. Improving Gastrointestinal Recovery after Radiation
    George Georges; Fiscal Year: 2007
    ..The drugs are: keratinocyte growth factor (KGF), lithium carbonate (Li2CO3), and a GI-specific formulation of beclomethasone dipropionate (BDP) to be given alone or in ..
  8. Electrochemical Home Monitoring System for Lithium Blood Level
    LINDA A TEMPELMAN; Fiscal Year: 2010
    ..by applicant): Electrochemical Home Monitoring System for Lithium Blood Level Lithium in the form of lithium carbonate is an important pharmacological treatment option in bipolar disorder and other conditions...
  9. LITHIUM IN AGGRESSIVE CHILDREN WITH CONDUCT DISORDER
    Magda Campbell; Fiscal Year: 1993
    ..We have replicated our earlier findings on the efficacy and safety of lithium carbonate in this type of child: lithium is statistically and clinically superior to placebo in reducing these target ..
  10. COGNITIVE THERAPY AND PHARMACOTHERAPY FOR DEPRESSION
    STEVEN HOLLON; Fiscal Year: 2000
    ..The PT condition entails the use of paroxetine, augmented by lithium carbonate after eight weeks for those patients who do not respond to desipramine by that time...
  11. COGNITIVE THERAPY AND PHARMACOTHERAPY FOR DEPRESSION
    ROBERT DERUBEIS; Fiscal Year: 2000
    ..The PT condition entails the use of paroxetine, augmented by lithium carbonate after eight weeks for those patients who do not respond to desipramine by that time...
  12. MAINTENANCE THERAPIES IN BIPOLAR DISORDERS
    Ellen Frank; Fiscal Year: 2002
    ..psychotherapy based on interpersonal and social rhythm principles in bipolar I patients maintained on lithium carbonate. An adaptation of maintenance interpersonal psychotherapy, this intervention takes into account the specific ..
  13. CONTINUATION PHARMACOTHERAPY FOLLOWING ECT
    Roger Haskett; Fiscal Year: 1999
    ..will be used to establish the relative efficacies of placebo, nortriptyline, and combination nortriptyline-lithium carbonate continuation therapies in the prevention of relapse in unipolar patients following response to ECT...
  14. 3 DIMENSIONAL QUANTITATIVE LITHIUM MRI IN HUMAN BRAIN
    Fernando Boada; Fiscal Year: 1999
    b>Lithium carbonate is used for the treatment and prophylaxis of affective illnesses. The established practice is to design a treatment regime aimed at achieving a serum lithium concentration (SLC) in the range of 0.6 to 1.0 mmol/liter...
  15. EFFICACY OF VALPROATE MAINTENANCE IN BIPOLAR ALCOHOLICS
    Ihsan Salloum; Fiscal Year: 2000
    ..aims: 1) Examine the efficacy of sodium valproate plus a procedurally specified Treatment-As-Usual (TAU = lithium carbonate + counseling) condition compared to a placebo plus TAU in the stabilization of acute manic episodes in ..
  16. CONTINUATION PHARMACOTHERAPY FOLLOWING ECT
    Harold Sackeim; Fiscal Year: 1999
    ..design is used to test the relative efficacies of placebo, nortriptyline, and combination nortriptyline-lithium carbonate treatments in preventing relapse following ECT response in primary unipolar patients...
  17. CONTINUATION OF PHARMACOTHERAPY FOLLOWING ECT
    Raymond Crowe; Fiscal Year: 1999
    ..design is used to test the relative efficacies of placebo, nortriptyline, and combination nortriptyline-lithium carbonate treatments in preventing relapse following ECT response in primary unipolar patients...
  18. LIPOPHILIC LI+ ION FLUOROPHORES
    MARGARET LANGMUIR; Fiscal Year: 1992
    ..samples could easily be performed in the psychiatrist's office to determine patient compliance with his/her lithium carbonate therapy...
  19. Bipolar Statistical Summit:Methodologies to Advance Long Term Intervention Trials
    Charles Bowden; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  20. Antidepressant discontinuation effects
    Ross Baldessarini; Fiscal Year: 2007
    ..bipolar depressive subjects separately. The findings expected should contribute to improved safety of antidepressant treatment and reduced morbid and mortal risks following its discontinuation. [unreadable] [unreadable]..
  21. Course and Morbidity in Bipolar I Disorder
    Ross Baldessarini; Fiscal Year: 2006
    ..Anticipated findings should contribute important new information to guide effective interventions and allocation of increasingly limited treatment resources for BPD patients. ..
  22. TREATMENT OF EARLY ONSET SCHIZOPHRENIA SPECTRUM (TEOSS)
    Robert Findling; Fiscal Year: 2005
    ..This study will provide information about the comparative effectiveness of the most commonly used and representative antipsychotic drugs in youth with schizophrenia spectrum disorders. ..
  23. S-Adenosyl Methionine(SAMe)Augmentation of SSRIs in MDD
    George Papakostas; Fiscal Year: 2008
    ..It is hoped that this project award will provide the critical fund of basic knowledge and practical experience necessary to aid the candidate in becoming an independent investigator in this area. ..
  24. Pharmacotherapy for Minor Depression
    Robert Howland; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  25. Pharmacotherapy for Minor Depression
    Andrew Nierenberg; Fiscal Year: 2004
    ..The results of this study will have profound public health implications by improving our understanding of the efficacy of SJW and standard antidepressants for the treatment of MinorD. ..
  26. Pramipexole in Treatment-Resistant Depression
    Roy Perlis; Fiscal Year: 2007
    ..The proposed investigation and training program will provide critical skills, experience and data to aid the candidate in writing an R01 and becoming an independent investigator. ..
  27. Aging, White Matter Changes, Executive Dysfunction and Depression
    Robert Young; Fiscal Year: 2007
    ..The clinical significance of the proposed study is that it can guide research leading to physiologically meaningful, novel antidepressant therapies aimed at aging-related frontal system dysfunction. [unreadable] [unreadable]..
  28. Black cohosh therapy for menopause-related anxiety
    Jay Amsterdam; Fiscal Year: 2006
    ..We hypothesize that Black Cohosh will result in superior QOL measures compared to placebo. ..
  29. PROPHYLACTIC COGNITIVE THERAPY FOR DEPRESSION
    Michael E Thase; Fiscal Year: 2010
    ....
  30. SPECT Brain Imaging as a Biomarker of Major Depression
    Jay Amsterdam; Fiscal Year: 2007
    ..We will compare these results to measurements of striatal DAT levels in 22 non-depressed, healthy subjects studied under similar conditions with [99mTc]TRODAT-1 SPECT on two separate occasions 8 weeks apart. ..
  31. Chamomile therapy for generalized anxiety disorder
    Jay Amsterdam; Fiscal Year: 2006
    ....
  32. Comparative Effectiveness Study for Bipolar Disorder
    Andrew A Nierenberg; Fiscal Year: 2010
    ..The two treatments will be the second generation antipsychotic mood stabilizer quetiapine and the classic mood stabilizer lithium. In addition to quetiapine or lithium, participants can be treated with other medications as needed. ..
  33. Treating PMS/PMDD--Research versus Clinical Reality
    Kimberly Yonkers; Fiscal Year: 2003
    ....
  34. ERT, DEPRESSION AND COGNITION IN POSTMENOPAUSAL WOMEN
    Natalie Rasgon; Fiscal Year: 2002
    ..antidepressant alone. This research will be the foundation for a future investigation of pathophysiology of reproductive-related mood disorders. ..
  35. Reducing Barriers to Pediatric Asthma Treatment Adheren*
    Dennis Drotar; Fiscal Year: 2004
    ....
  36. PHARMACOTHERAPY OF ADOLESCENT BODY DYSMORPHIC DISORDER
    Eric Hollander; Fiscal Year: 2002
    ..When untreated, adolescent-onset BDD appears to often interfere with the developmental tasks of adolescence, to persist, and to cause substantial morbidity through out the life span. ..
  37. Combination Therapy in Bipolar Rapid Cycling
    Joseph Calabrese; Fiscal Year: 2004
    ....
  38. Estrogen Use in Protection from Cognitive Decline
    Natalie L Rasgon; Fiscal Year: 2010
    ..abstract_text> ..
  39. Diabetes and Drug-Associated Hyperkalemia: Effect of Laboratory Monitoring
    Marsha Raebel; Fiscal Year: 2008
    ..The findings will also assist in developing a framework for future studies to evaluate the effects and costs of medication-laboratory monitoring among patients with diabetes. [unreadable] [unreadable] [unreadable] [unreadable]..
  40. Glycine Transport Inhibition for Nicotine Dependence in Schizophrenia
    A Evins; Fiscal Year: 2009
    ....
  41. Training in Psychopharmacology and Outcomes Research
    Eric Hollander; Fiscal Year: 2008
    ..of Medicine of Medicine of Medicine of Medicine of Medicine of Medicine format shown below. Role on ..
  42. Course and Outcome for Bipolar Disorder in Youth
    Michael A Strober; Fiscal Year: 2010
    ....
  43. Family-Focused Treatment for Bipolar Adolescents
    DAVID JAY MIKLOWITZ; Fiscal Year: 2010
    ..At the study's completion, we will have obtained a knowledge base to help develop a best practice model of treatment for BP adolescents that integrates family-focused problem-solving with psychopharmacology. ..
  44. COLLABORATIVE DEPRESSION STUDY
    William Coryell; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  45. Treating Depressed Mothers in a Community Clinic
    Holly Swartz; Fiscal Year: 2006
    ..The skills, training, and pilot data obtained from this award will subsequently support the Candidate's development of an R01 application in Years 03-05 of the award period. ..
  46. Divalproex Sodium/Placebo In Child/Adolesent Autism
    Eric Hollander; Fiscal Year: 2003
    ....
  47. Continuation ECT vs Pharmacotherapy: Efficacy and Safety
    Charles Kellner; Fiscal Year: 2003
    ..When completed, this project will provide the first and definitive data on the role of C-ECT in the treatment of serious affective illness. ..
  48. PEDIATRIC BIPOLAR COLLABORATIVE MOOD STABILZER TRAIL
    Robert Findling; Fiscal Year: 2003
    ..Lastly, this trial will provide descriptive information on the stability of acute phase response to monotherapy over a 16 week continuation phase. ..
  49. FAMILY PSYCHOPATHOLOGY IN CHILD BIPOLARITY
    Barbara Geller; Fiscal Year: 2004
    ..Establishing high familial aggregation of bipolar disorders in relatives of PEA-BP probands will provide the basis for future genetic and genetic-environment interaction studies. ..
  50. Cardiac-Related Mortality with Atypical Antipsychotics
    DEANNA KELLY; Fiscal Year: 2005
    ..This study is important as data on long-term health outcomes with atypical antipsychotics is lacking from the literature. ..
  51. EXTRAMURAL RESEARCH FACILITIES IMPROVEMENT
    Russell Joffe; Fiscal Year: 2004
    ..No funds are sought for basic science research laboratories or any clinical areas in the Cancer Center. ..
  52. OPTIMIZATION OF ELECTROCONVULSIVE THERAPY
    Harold Sackeim; Fiscal Year: 2005
    ....
  53. NICOTINE AND SMOKING CESSATION IN SCHIZOPHRENIA
    A Evins; Fiscal Year: 2005
    ....
  54. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Keith Rasmussen; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  55. COMPARING THREE ELECTRODE PLACEMENTS TO OPTIMIZE ECT
    Charles Kellner; Fiscal Year: 2005
    ..The results of this study will promote more effective and safer treatment of the most severely ill depressed patients. ..
  56. REGIONAL BIOCONTAINMENT LABORATORY (RBL) NEWARK CENTER
    Russell Joffe; Fiscal Year: 2005
    ..When the RBL is operational, it will create a critical mass of biodefense scientists in Newark and serve as a specialized laboratory for emerging regional and national biodefense needs. ..
  57. Long-term antidepressant outcome in bipolar depression
    NASSIR GHAEMI; Fiscal Year: 2005
    ..In this process, the applicant will develop competence to lead independent studies of the long-term treatment of bipolar disorder as a principal investigator. ..
  58. Magnetic Resonance Spectroscopy in Affective Illness
    CONSTANCE MOORE; Fiscal Year: 2005
    ..Decreased caudate nucleus beta-NTP will be associated with depression. An increase in caudate nucleus PME will occur as a result of lithium treatment. ..
  59. Divalproex sodium and Risperidone in Pediatric Bipolar Disorder
    Mani Pavuluri; Fiscal Year: 2007
    ..During five years, 40 outpatient subjects with PBD manic or mixed episodes, ages 8-17 years, referred to the UI Pediatric Mood Disorder Clinic will be recruited. ..