fluorine radioisotopes

Summary

Summary: Unstable isotopes of fluorine that decay or disintegrate emitting radiation. F atoms with atomic weights 17, 18, and 20-22 are radioactive fluorine isotopes.

Top Publications

  1. ncbi Imaging proliferation in vivo with [F-18]FLT and positron emission tomography
    A F Shields
    Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit Medical Center, MI 48301, USA
    Nat Med 4:1334-6. 1998
  2. ncbi Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells
    Janet S Rasey
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Nucl Med 43:1210-7. 2002
  3. ncbi A novel method of 18F radiolabeling for PET
    William J McBride
    Immunomedics, Inc, 300 American Way, Morris Plains, NJ 07950, USA
    J Nucl Med 50:991-8. 2009
  4. ncbi Skeletal PET with 18F-fluoride: applying new technology to an old tracer
    Frederick D Grant
    Division of Nuclear Medicine PET, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Nucl Med 49:68-78. 2008
  5. ncbi 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
    Henryk Barthel
    Cancer Research United Kingdom PET Oncology Group, Department of Cancer Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London W12 0NN, United Kingdom
    Cancer Res 63:3791-8. 2003
  6. pmc Molecular mechanisms of bone 18F-NaF deposition
    Johannes Czernin
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1782, USA
    J Nucl Med 51:1826-9. 2010
  7. pmc New lyophilized kit for rapid radiofluorination of peptides
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey, USA
    Bioconjug Chem 23:538-47. 2012
  8. ncbi Quantification of skeletal kinetic indices in Paget's disease using dynamic 18F-fluoride positron emission tomography
    G J R Cook
    Department of Nuclear Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    J Bone Miner Res 17:854-9. 2002
  9. pmc A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 334:639-42. 2011
  10. ncbi Inorganic approaches for radiolabelling biomolecules with fluorine-18 for imaging with positron emission tomography
    Gareth E Smith
    King s College London, Division of Imaging Sciences, St Thomas Hospital, 4th Floor Lambeth Wing, London, UK SE1 7EH
    Dalton Trans 40:6196-205. 2011

Research Grants

  1. PET Imaging of the Pancreas in Murine Models of Diabetes
    Paige Clark; Fiscal Year: 2005
  2. F-18 FDG Peptides for Pretargeted PET Imaging of Pancrea
    William McBride; Fiscal Year: 2005
  3. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2006
  4. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
  5. Small Animal PET (microPET)
    JOGESH MUKHERJEE; Fiscal Year: 2007
  6. Radiolabeled Probes for Imaging Caspase 3 Activation
    Robert Mach; Fiscal Year: 2008
  7. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
  8. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
  9. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
  10. PET IMAGING OF DRUG KINETICS AND PATHWAYS
    Anthony Shields; Fiscal Year: 2002

Detail Information

Publications261 found, 100 shown here

  1. ncbi Imaging proliferation in vivo with [F-18]FLT and positron emission tomography
    A F Shields
    Karmanos Cancer Institute, Department of Medicine, Wayne State University, Detroit Medical Center, MI 48301, USA
    Nat Med 4:1334-6. 1998
    ....
  2. ncbi Validation of FLT uptake as a measure of thymidine kinase-1 activity in A549 carcinoma cells
    Janet S Rasey
    Department of Radiation Oncology, University of Washington School of Medicine, Seattle, Washington 98195, USA
    J Nucl Med 43:1210-7. 2002
    ..We tested the accuracy with which FLT uptake predicted the activity of cytosolic thymidine kinase-1 (TK(1)), an enzyme that is upregulated before and during DNA synthesis...
  3. ncbi A novel method of 18F radiolabeling for PET
    William J McBride
    Immunomedics, Inc, 300 American Way, Morris Plains, NJ 07950, USA
    J Nucl Med 50:991-8. 2009
    ..We report a facile method wherein (18)F is first attached to aluminum as Al(18)F, which is then bound to a chelate attached to a peptide, forming a stable Al(18)F-chelate-peptide complex in an efficient 1-pot process...
  4. ncbi Skeletal PET with 18F-fluoride: applying new technology to an old tracer
    Frederick D Grant
    Division of Nuclear Medicine PET, Children s Hospital Boston, Boston, Massachusetts 02115, USA
    J Nucl Med 49:68-78. 2008
    ..The favorable imaging performance and the clinical utility of (18)F-fluoride PET, compared with (99m)Tc-diphosphonate scintigraphy, support the reconsideration of (18)F-fluoride as a routine bone-imaging agent...
  5. ncbi 3'-deoxy-3'-[18F]fluorothymidine as a new marker for monitoring tumor response to antiproliferative therapy in vivo with positron emission tomography
    Henryk Barthel
    Cancer Research United Kingdom PET Oncology Group, Department of Cancer Medicine, Faculty of Medicine, Imperial College of Science, Technology and Medicine, Hammersmith Hospital Campus, London W12 0NN, United Kingdom
    Cancer Res 63:3791-8. 2003
    ..The decrease in [(18)F]FLT uptake after 5-FU was more pronounced than that of [(18)F]FDG. [(18)F]FLT is, therefore, a promising marker for monitoring antiproliferative drug activity in oncology that warrants additional testing...
  6. pmc Molecular mechanisms of bone 18F-NaF deposition
    Johannes Czernin
    Ahmanson Biological Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1782, USA
    J Nucl Med 51:1826-9. 2010
    ....
  7. pmc New lyophilized kit for rapid radiofluorination of peptides
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey, USA
    Bioconjug Chem 23:538-47. 2012
    ....
  8. ncbi Quantification of skeletal kinetic indices in Paget's disease using dynamic 18F-fluoride positron emission tomography
    G J R Cook
    Department of Nuclear Medicine, Royal Marsden Hospital, Sutton, Surrey, United Kingdom
    J Bone Miner Res 17:854-9. 2002
    ....
  9. pmc A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA
    Science 334:639-42. 2011
    ..Late-stage fluorination enables the synthesis of conventionally unavailable positron emission tomography (PET) tracers for anticipated applications in pharmaceutical development as well as preclinical and clinical PET imaging...
  10. ncbi Inorganic approaches for radiolabelling biomolecules with fluorine-18 for imaging with positron emission tomography
    Gareth E Smith
    King s College London, Division of Imaging Sciences, St Thomas Hospital, 4th Floor Lambeth Wing, London, UK SE1 7EH
    Dalton Trans 40:6196-205. 2011
    ..The promise already shown by these early studies heralds a new branch of bioconjugate radiochemistry involving a wider range of "fluoridephilic" elements for synthesis of PET molecular imaging agents...
  11. ncbi Reduced PBR/TSPO expression after minocycline treatment in a rat model of focal cerebral ischemia: a PET study using [(18)F]DPA-714
    Abraham Martin
    CEA, DSV, I BM, SHFJ, Laboratoire Imagerie Moléculaire Expérimentale, INSERM U803, 4 Place Géneral Leclerc, 91406 Orsay Cedex, France
    Mol Imaging Biol 13:10-5. 2011
    ..This overexpression can be imaged with positron emission tomography (PET) using PBR/TSPO-selective radioligands such as [(18)F]DPA-714...
  12. ncbi 18F-FEAC and 18F-FEDAC: PET of the monkey brain and imaging of translocator protein (18 kDa) in the infarcted rat brain
    Joji Yui
    Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    J Nucl Med 51:1301-9. 2010
    ....
  13. pmc Fast 18F labeling of a near-infrared fluorophore enables positron emission tomography and optical imaging of sentinel lymph nodes
    Richard Ting
    Department of Pharmacology, University of California, San Diego, La Jolla, California 92093, USA
    Bioconjug Chem 21:1811-9. 2010
    ..Facile incorporation of (18)F into a NIRF probe should promote many synergistic PET and NIRF combinations...
  14. ncbi In vivo imaging of neuroinflammation: a comparative study between [(18)F]PBR111, [ (11)C]CLINME and [ (11)C]PK11195 in an acute rodent model
    Nadja Van Camp
    CEA, I2BM, SHFJ, Laboratoire d Imagerie Moléculaire Expérimentale LIME, 4 place Leclerc, 91400 Orsay, France
    Eur J Nucl Med Mol Imaging 37:962-72. 2010
    ....
  15. ncbi The predictive value of preoperative fluorine-18-L-3,4-dihydroxyphenylalanine positron emission tomography-computed tomography scans in children with congenital hyperinsulinism of infancy
    Augusto Zani
    Department of Paediatric Surgery, Institute of Child Health and Great Ormond Street Hospital for Children, Great Ormond Street, London, United Kingdom
    J Pediatr Surg 46:204-8. 2011
    ..The aim of this study was to evaluate the accuracy of this technique in discriminating between diffuse and focal CHI and the anatomical localization of focal lesions...
  16. ncbi Evaluation of [18F]-tetrafluoroborate as a potential PET imaging agent for the human sodium/iodide symporter in a new colon carcinoma cell line, HCT116, expressing hNIS
    Amanda J Weeks
    Division of Imaging Sciences, King s College London, St Thomas Hospital, London, UK
    Nucl Med Commun 32:98-105. 2011
    ..There is no readily available positron emission tomography (PET) tracer for hNIS. Our aim was to develop a colon carcinoma cell line stably expressing hNIS, and use it to evaluate a novel hNIS PET tracer, [18F]-tetrafluoroborate...
  17. ncbi Synthesis, 18F-labeling, and in vitro and in vivo studies of bombesin peptides modified with silicon-based building blocks
    Aileen Höhne
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, Department of Chemistry and Applied Biosciences, ETH Zurich, CH 8093 Zurich, Switzerland
    Bioconjug Chem 19:1871-9. 2008
    ..c. a. radiolabeling method for the synthesis of new 18F-labeled bombesin derivatives. This innovative approach represents a general, straightforward access to radiolabeled peptides as PET imaging probes...
  18. ncbi Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer
    David T Price
    Department of Radiology, Duke University Medical Center, Durham, North Carolina, USA
    J Urol 168:273-80. 2002
    ..We evaluated the novel choline analog [18F]fluorocholine (FCH) for detecting androgen dependent and androgen independent prostate cancer, and its metastases...
  19. ncbi Noninvasive diagnosis of focal hyperinsulinism of infancy with [18F]-DOPA positron emission tomography
    Timo Otonkoski
    Hospital for Children and Adolescents, and Program of Developmental and Reproductive Biology, Biomedicum Helsinki, Room C503b, PO Box 63, FIN 00014 University of Helsinki, Helsinki, Finland
    Diabetes 55:13-8. 2006
    ..In conclusion, [(18)F]-DOPA PET is a promising noninvasive method for the identification and localization of the focal form of CHI...
  20. pmc Evaluation of the PBR/TSPO radioligand [(18)F]DPA-714 in a rat model of focal cerebral ischemia
    Abraham Martin
    INSERM U803, Orsay, France
    J Cereb Blood Flow Metab 30:230-41. 2010
    ..These results show that [(18)F]DPA-714 provides accurate quantitative information of the time course of PBR/TSPO expression in experimental stroke...
  21. ncbi The detection of bone metastases in patients with high-risk prostate cancer: 99mTc-MDP Planar bone scintigraphy, single- and multi-field-of-view SPECT, 18F-fluoride PET, and 18F-fluoride PET/CT
    Einat Even-Sapir
    Department of Nuclear Medicine, Tel Aviv Sourasky Medical Center, Tel Aviv, Israel
    J Nucl Med 47:287-97. 2006
    ..The aim of this study was to compare the detection of bone metastases by 99mTc-methylene diphosphonate (99mTc-MDP) planar bone scintigraphy (BS), SPECT, 18F-Fluoride PET, and 18F-Fluoride PET/CT in patients with high-risk prostate cancer...
  22. ncbi Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation
    Fabien Chauveau
    CEA, DSV, I2BM, LIME, Orsay, France
    J Nucl Med 50:468-76. 2009
    ....
  23. pmc A novel facile method of labeling octreotide with (18)F-fluorine
    Peter Laverman
    Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Nucl Med 51:454-61. 2010
    ..The method is characterized by the labeling of NOTA-octreotide (NOTA-d-Phe-cyclo[Cys-Phe-d-Trp-Lys-Thr-Cys]-Throl (MH(+) 1305) [IMP466]) with (18)F...
  24. ncbi DPA-714, a new translocator protein-specific ligand: synthesis, radiofluorination, and pharmacologic characterization
    Michelle L James
    Department of Pharmacology, University of Sydney, Sydney, New South Wales, Australia
    J Nucl Med 49:814-22. 2008
    ..Radioligands for the TSPO can therefore measure active disease in the brain. This article details the synthesis, radiofluorination, and pharmacologic evaluation of a new TSPO-specific pyrazolopyrimidine, DPA-714...
  25. pmc [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Mol Imaging Biol 11:386-98. 2009
    ..In this study, we evaluated the PET tracers [(11)C]-DPA-713 and [(18)F]-DPA-714 as agents for imaging of activated microglia in a rat model of herpes encephalitis...
  26. ncbi [18F]Fluorothymidine positron emission tomography before and 7 days after gefitinib treatment predicts response in patients with advanced adenocarcinoma of the lung
    Hee Jung Sohn
    Division of Oncology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea
    Clin Cancer Res 14:7423-9. 2008
    ..To evaluate the usefulness of 3'-deoxy-3'-[18F]fluorothymidine (FLT)-positron emission tomography (PET) for predicting response and patient outcome of gefitinib therapy in patients with adenocarcinoma of the lung...
  27. pmc Improved 18F labeling of peptides with a fluoride-aluminum-chelate complex
    William J McBride
    Immunomedics, Inc, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 21:1331-40. 2010
    ..The IMP467 peptide could be labeled up to 115 GBq/micromol (3100 Ci/mmol), with a total reaction and purification time of 30 min without chromatographic purification...
  28. pmc Fast and high-yield microreactor syntheses of ortho-substituted [(18)F]fluoroarenes from reactions of [(18)F]fluoride ion with diaryliodonium salts
    Joong Hyun Chun
    PET Radiopharmaceutical Sciences Section, Molecular Imaging Branch, National Institute of Mental Health, Rm B3 C346A, Building 10, 10 Center Drive, Bethesda, Maryland 20892 1003, USA
    J Org Chem 75:3332-8. 2010
    ..These results will aid in the design of diaryliodonium salt precursors to (18)F-labeled tracers for molecular imaging...
  29. ncbi Differential effects of teriparatide on regional bone formation using (18)F-fluoride positron emission tomography
    Michelle L Frost
    Osteoporosis Research Unit, Division of Imaging Sciences, King s College London, Guy s Campus, London, UK
    J Bone Miner Res 26:1002-11. 2011
    ..We conclude that the changes in bone formation rate during teriparatide treatment as measured by (18)F(-) PET differ at different skeletal sites, with larger increases in cortical bone than at trabecular sites...
  30. ncbi Congenital hyperinsulinism: pancreatic [18F]fluoro-L-dihydroxyphenylalanine (DOPA) positron emission tomography and immunohistochemistry study of DOPA decarboxylase and insulin secretion
    Pascale de Lonlay
    Departement de Pediatrie, Hopital Necker Enfants Malades, Universite Paris Descartes, Faculte de Medecine, 149 rue de Sevres, 75743 Paris Cedex 15, France
    J Clin Endocrinol Metab 91:933-40. 2006
    ..Preoperative differential diagnosis was based on pancreatic venous sampling, a technically demanding technique...
  31. ncbi Effects of alendronate on bone metabolism in glucocorticoid-induced osteoporosis measured by 18F-fluoride PET: a prospective study
    Kenzo Uchida
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan
    J Nucl Med 50:1808-14. 2009
    ....
  32. ncbi Whole-body 18F dopa PET for detection of gastrointestinal carcinoid tumors
    S Hoegerle
    Department of Radiology, Division of Nuclear Medicine, Albert-Ludwigs University, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Radiology 220:373-80. 2001
    ..CONCLUSION: 18F dopa PET is a promising procedure and useful supplement to morphologic methods in diagnostic imaging of gastrointestinal carcinoid tumors...
  33. ncbi Protein labeling with the labeling precursor [(18)F]SiFA-SH for positron emission tomography
    Björn Wängler
    Molecular Imaging and Radiochemistry, Medical Faculty Mannheim, Department of Clinical Radiology and Nuclear Medicine, Heidelberg University, Mannheim, Germany
    Nat Protoc 7:1964-9. 2012
    ..Not more than two maleimide groups are introduced using sulfo-SMCC, thereby keeping the modification of the protein low and preserving its biological activity...
  34. pmc The translocator protein ligand [¹⁸F]DPA-714 images glioma and activated microglia in vivo
    Alexandra Winkeler
    INSERM, U1023, Laboratoire d Imagerie Moleculaire Experimentale, Universite Paris Sud, Orsay, France
    Eur J Nucl Med Mol Imaging 39:811-23. 2012
    ..Here we investigated the use of [(18)F]DPA-714, a new TSPO positron emission tomography (PET) radioligand to image glioma in vivo...
  35. pmc In vivo positron emission tomography (PET) imaging with an alphavbeta6 specific peptide radiolabeled using 18F-"click" chemistry: evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F]fluoropropionyl-peptides
    Sven H Hausner
    Department of Biomedical Engineering, University of California Davis, Davis, California 95616, USA
    J Med Chem 51:5901-4. 2008
    ..Here we compare the three different radiolabeling approaches and report the effects on PET imaging and pharmacokinetics. The prosthetic groups did have an effect; metabolites with significantly different polarities were observed...
  36. ncbi Imaging microglial/macrophage activation in spinal cords of experimental autoimmune encephalomyelitis rats by positron emission tomography using the mitochondrial 18 kDa translocator protein radioligand [¹⁸F]DPA-714
    Galith Abourbeh
    INSERM, Unité 1023, Universite Paris Sud, 91400 Orsay, France
    J Neurosci 32:5728-36. 2012
    ..In addition to current MRI protocols, this approach could provide molecular images of neuroinflammation for detection, monitoring, and research in MS...
  37. ncbi The precision and sensitivity of (18)F-fluoride PET for measuring regional bone metabolism: a comparison of quantification methods
    Musib Siddique
    King s College London, Osteoporosis Screening and Research Unit, Guy s Hospital, London, UK
    J Nucl Med 52:1748-55. 2011
    ....
  38. ncbi Chelator-accelerated one-pot 'click' labeling of small molecule tracers with 2-[¹⁸F]fluoroethyl azide
    Eva Galante
    Department of Chemistry and Institute of Nuclear Medicine, University College London, 235 Euston Road, T 5, London NW1 2BU, UK
    Molecules 18:5335-47. 2013
    ..The method was demonstrated by reacting [¹⁸F]FEA with a series of alkyne-functionalized 6-halopurines to give the corresponding triazoles in 55-76% analytical radiochemical yield...
  39. ncbi Synthesis of 6-[¹⁸F]fluoro-PBR28, a novel radiotracer for imaging the TSPO 18 kDa with PET
    Annelaure Damont
    CEA, I BM, Service Hospitalier Frederic Joliot, Orsay, France
    Bioorg Med Chem Lett 21:4819-22. 2011
    ....
  40. ncbi Brain imaging of 18F-fallypride in normal volunteers: blood analysis, distribution, test-retest studies, and preliminary assessment of sensitivity to aging effects on dopamine D-2/D-3 receptors
    Jogeshwar Mukherjee
    Department of Nuclear Medicine PET, Kettering Medical Center, Dayton, Ohio 45429, USA
    Synapse 46:170-88. 2002
    ..PET studies with 18F-fallypride are thus suitable to study changes in D2/D3 receptors in striatal and extrastriatal brain regions...
  41. ncbi Radiosynthesis and initial evaluation of [18F]-FEPPA for PET imaging of peripheral benzodiazepine receptors
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada M5T 1R8
    Nucl Med Biol 35:305-14. 2008
    ..A novel [18F]-radiolabelled phenoxyanilide, [18F]-FEPPA, has been synthesized and evaluated, in vitro and ex vivo, as a potential positron emission tomography imaging agent for the peripheral benzodiazepine receptor (PBR)...
  42. ncbi Transport of 3-fluoro-L-α-methyl-tyrosine by tumor-upregulated L-type amino acid transporter 1: a cause of the tumor uptake in PET
    Pattama Wiriyasermkul
    Division of Bio system Pharmacology, Department of Pharmacology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    J Nucl Med 53:1253-61. 2012
    ..In this study, we examined the interaction of 3-fluoro-l-α-methyl-tyrosine (FAMT) with amino acid transporters to assess the mechanisms of (18)F-FAMT uptake in PET...
  43. ncbi Labeling strategies of peptides with ¹⁸F for positron emission tomography
    D E Olberg
    University of Tromsø, Institute of Pharmacy, Department of Pharmaceutics and Biopharmaceutics, Tromsø, Norway
    Curr Top Med Chem 10:1669-79. 2010
    ..In this review, the aim is to provide an overview and discuss the strategies currently used for labeling of peptides with ¹⁸F for PET...
  44. ncbi Radio fluorination and positron emission tomography (PET) as a new approach to study the in vivo distribution and elimination of the advanced glycation endproducts N epsilon-carboxymethyllysine (CML) and N epsilon-carboxyethyllysine (CEL)
    R Bergmann
    Research Centre Rossendorf, Institute of Bioinorganic and Radiopharmaceutical Chemistry, Rossendorf
    Nahrung 45:182-8. 2001
    ..PET based on 18F-labelled AGEs proved to be a promising tool to elucidate the physiological fate of post-translationally modified amino acids and to clarify the role of AGEs as possible "glycotoxins"...
  45. pmc High-yielding aqueous 18F-labeling of peptides via Al18F chelation
    Christopher A D'Souza
    Immunomedics Inc, 300 American Road, Morris Plains, New Jersey 07950, USA
    Bioconjug Chem 22:1793-803. 2011
    ..These results demonstrate the facile application of Al(18)F chelation using BFC 1 as a versatile labeling method for radiofluorinating other heat-stable peptides for positron emission imaging...
  46. ncbi Two-step methodology for high-yield routine radiohalogenation of peptides: (18)F-labeled RGD and octreotide analogs
    Thorsten Poethko
    Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universitat Munchen, Munchen, Germany
    J Nucl Med 45:892-902. 2004
    ....
  47. ncbi Cancer imaging with fluorine-18-labeled choline derivatives
    Sandi A Kwee
    University of Hawaii John A Burns School of Medicine, Honolulu, HI 96813, USA
    Semin Nucl Med 37:420-8. 2007
    ..These features, along with the possibility of imaging malignancies that have proved elusive with the use of (18)F-fluorodeoxyglucose positron emission tomography support further clinical investigations of (18)F-labeled choline tracers...
  48. ncbi Detection of bone metastases in patients with lung cancer: 99mTc-MDP planar bone scintigraphy, 18F-fluoride PET or 18F-FDG PET/CT
    Stefan Kruger
    Medical Clinic II, University Hospital, Ulm, Germany
    Eur J Nucl Med Mol Imaging 36:1807-12. 2009
    ....
  49. ncbi Novel matrix metalloproteinase inhibitor [18F]marimastat-aryltrifluoroborate as a probe for in vivo positron emission tomography imaging in cancer
    Ulrich auf dem Keller
    UBC Centre for Blood Research, Department of Oral Biological and Medical Sciences, University of British Columbia, Vancouver, British Columbia, Canada
    Cancer Res 70:7562-9. 2010
    ..The labeled drug cleared primarily via the hepatobiliary and gastrointestinal tract, with multiple animals imaged in independent experiments, confirming the ease of this new labeling strategy...
  50. pmc Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride
    Eunsung Lee
    Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA
    J Am Chem Soc 134:17456-8. 2012
    ....
  51. ncbi (18)F-fluoride PET for monitoring therapeutic response in Paget's disease of bone
    Johanne Installé
    Department of Molecular Imaging and Experimental Radiotherapy, Catholic University of Louvain, Brussels, Belgium
    J Nucl Med 46:1650-8. 2005
    ..A prospective study was undertaken to evaluate PET with (18)F-fluoride for monitoring the response to bisphosphonates in Paget's disease of bones...
  52. pmc Small-animal PET imaging of human epidermal growth factor receptor type 2 expression with site-specific 18F-labeled protein scaffold molecules
    Zhen Cheng
    Molecular Imaging Program at Stanford, Department of Radiology, Bio X Program, Stanford University, Stanford, California 94305, USA
    J Nucl Med 49:804-13. 2008
    ....
  53. ncbi Comparison of [18F]-tracers in various experimental tumor models by PET imaging and identification of an early response biomarker for the novel microtubule stabilizer patupilone
    T Ebenhan
    Global Imaging Group, Novartis Institute of Biomedical Research, 4002 Basel, Switzerland
    Mol Imaging Biol 11:308-21. 2009
    ..The suitability of [18F]FDG, [18F]FLT, [18F]FET, and [18F]FCH as non-invasive positron emission tomography (PET) biomarkers for monitoring response to chemotherapy was analyzed in various experimental tumor models...
  54. ncbi In vivo measurement of vesicular monoamine transporter type 2 density in Parkinson disease with (18)F-AV-133
    Nobuyuki Okamura
    Department of Nuclear Medicine and Centre for PET, Austin Health, Victoria, Australia
    J Nucl Med 51:223-8. 2010
    ..PET provides a noninvasive means to evaluate the functional integrity of the presynaptic monoaminergic system in the living human brain...
  55. ncbi Arylfluoroborates and alkylfluorosilicates as potential PET imaging agents: high-yielding aqueous biomolecular 18F-labeling
    Richard Ting
    Chemistry Department, University of British Columbia, Vancouver, Canada
    J Am Chem Soc 127:13094-5. 2005
    ..With the stability of both compounds ascertained, this work describes a novel and robust radiolabeling method that may find use in the development of positron emission tomography radiopharmaceuticals...
  56. ncbi Prospective evaluation of the clinical value of planar bone scans, SPECT, and (18)F-labeled NaF PET in newly diagnosed lung cancer
    H Schirrmeister
    Department of Nuclear Medicine, University of Ulm, Ulm, Germany
    J Nucl Med 42:1800-4. 2001
    ..Routinely performed SPECT imaging is practicable, is cost-effective, and improves the accuracy of BS...
  57. ncbi Quantitative studies of bone with the use of 18F-fluoride and 99mTc-methylene diphosphonate
    G M Blake
    Department of Nuclear Medicine, Guy's Hospital, London, England
    Semin Nucl Med 31:28-49. 2001
    ..However, comparable data could probably be obtained by using 99mTc-MDP if methods for single photon emission computed tomography (SPECT) quantitation were improved...
  58. ncbi PET quantitation and imaging of the non-pure positron-emitting iodine isotope 124I
    H Herzog
    Institute of Medicine, Forschungszentrum Jülich GmhH, Germany
    Appl Radiat Isot 56:673-9. 2002
    ..We conclude that quantitation of a radiopharmaceutical labelled with 124I is feasible and may be improved by the development of specific corrections...
  59. ncbi Synthesis and evaluation of (18)F-labeled choline analogs as oncologic PET tracers
    T R DeGrado
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Nucl Med 42:1805-14. 2001
    ..Preliminary PET studies on patients with prostate cancer and with breast cancer and brain tumor support further studies to evaluate the usefulness of FCH as an oncologic probe...
  60. ncbi Early detection of tumor response to chemotherapy by 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography: the effect of cisplatin on a fibrosarcoma tumor model in vivo
    Julius Leyton
    Molecular Therapy Group, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Cancer Res 65:4202-10. 2005
    ..This work supports the further development of [18F]FLT-PET as a generic pharmacodynamic readout for early quantitative imaging of drug-induced changes in cell proliferation in vivo...
  61. pmc Quantitative, preclinical PET of translocator protein expression in glioma using 18F-N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline
    Jason R Buck
    Vanderbilt University Institute of Imaging Science, Department of Radiologyh and Radiological Science, Vanderbilt University Medical Center, Nashville, Tennessee 37232 2310, USA
    J Nucl Med 52:107-14. 2011
    ....
  62. ncbi Evaluation of [18F]fluoro-L-DOPA positron emission tomography-computed tomography for surgery in focal congenital hyperinsulinism
    Winfried Barthlen
    Clinic for Pediatric Surgery, Institute for Pathology, Charite University Medicine Berlin, Campus Virchow Klinikum, Augustenburger Platz 1, Mittelallee 8, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 93:869-75. 2008
    ..In congenital hyperinsulinism (CHI), the identification and precise localization of a focal lesion is essential for successful surgery...
  63. ncbi Preparation of F-18 labeled annexin V: a potential PET radiopharmaceutical for imaging cell death
    J Toretsky
    Georgetown University, Washington, DC 20007, USA
    Nucl Med Biol 31:747-52. 2004
    ..We conclude that [18F] labeled annexin V can be readily prepared by the conjugation of annexin V with [18F]SFB and that the positron-emitting compound is biologically active in detecting apoptosis...
  64. ncbi Preparation of 18F-labeled peptides using the copper(I)-catalyzed azide-alkyne 1,3-dipolar cycloaddition
    Herman S Gill
    Department of Biomedical Imaging, Genentech Research and Early Development, Genentech Inc, South San Francisco, California, USA
    Nat Protoc 6:1718-25. 2011
    ..After an HPLC purification, (18)F-labeled peptide can be obtained with a 31 ± 6% radiochemical yield (n = 4, decay-corrected from (18)F-fluoride elution) and a specific activity of 39.0 ± 12.4 Ci μmol(-1) within 77 ± 4 min...
  65. ncbi Initial evaluation in healthy humans of [18F]DPA-714, a potential PET biomarker for neuroinflammation
    Nicolas Arlicot
    Universite Francois Rabelais de Tours, UMR S930 and CNRS ERL 3106, Tours, France
    Nucl Med Biol 39:570-8. 2012
    ..We aimed to estimate the radiation dosimetry of the positron emission tomography (PET) TSPO radioligand [(18)F]DPA-714, and we evaluated in healthy volunteers its whole-body uptake and cerebral kinetics...
  66. pmc Efficient 18F labeling of cysteine-containing peptides and proteins using tetrazine-trans-cyclooctene ligation
    Shuanglong Liu
    Department of Radiology, Keck School of Medicine, Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Mol Imaging 12:121-8. 2013
    ..The special characteristics of the tetrazine-trans-cyclooctene ligation provide unprecedented opportunities to synthesize 18F-labeled probes with high specific activity for PET applications...
  67. ncbi 18F-labelled annexin V: a PET tracer for apoptosis imaging
    Yoshihiro Murakami
    The Medical and Pharmacological Research Center Foundation, Wo32, 925 0613, Inoyama, Hakui, Ishikawa, Japan
    Eur J Nucl Med Mol Imaging 31:469-74. 2004
    ..The low uptake of [18F]annexin V in these organs might represent an advantage over [(99m)Tc]annexin V...
  68. ncbi Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models
    Smith Apisarnthanarax
    Department of Radiation Oncology, The University of Texas M D Anderson Cancer Center, Houston, 77030, USA
    Clin Cancer Res 12:4590-7. 2006
    ..We assessed the ability of 3'-deoxy-3'-(18)F-fluorothymidine positron emission tomography (FLT-PET) to detect early changes in tumor proliferation after chemoradiotherapy in experimental models of esophageal carcinoma...
  69. ncbi Monitoring of herpes simplex virus thymidine kinase enzyme activity using positron emission tomography
    G A Hospers
    Department of Medical Oncology, Groningen University Hospital, The Netherlands
    Cancer Res 60:1488-91. 2000
    ..In conclusion, we have demonstrated that [18F]FHPG is a promising tracer for monitoring HSV-tk enzyme activity in vivo with PET...
  70. ncbi 18F-labeled proteins
    Zhanhong Wu
    Department of Diabetes, Endocrinology and Metabolism, Beckman Research Institute of the City of Hope, 1500 East Duarte Road, Duarte, CA 91010, USA
    Curr Pharm Biotechnol 11:572-80. 2010
    ....
  71. ncbi O-(2-[18F]fluoroethyl)-L-tyrosine and L-[methyl-11C]methionine uptake in brain tumours: initial results of a comparative study
    W A Weber
    Department of Nuclear Medicine, Technische Universitat Munchen, Germany
    Eur J Nucl Med 27:542-9. 2000
    ..The specificity of FET for tumour tissue is promising but has to be addressed in a larger series of patients with non-neoplastic lesions...
  72. pmc Direct site-specific radiolabeling of an Affibody protein with 4-[18F]fluorobenzaldehyde via oxime chemistry
    Mohammad Namavari
    Molecular Imaging Program at Stanford, Department of Radiology and Bioengineering, Bio X Program, Stanford University, 318 Campus Dr, Clark Center, E 150, Stanford, CA 94305, USA
    Mol Imaging Biol 10:177-81. 2008
    ..In this study, we introduce a methodology for preparing 18F-labeled Affibody protein, specifically 18F-Anti-HER2 dimeric Affibody (14 kDa), for in vivo imaging of HER2neu with positron emission tomography (PET)...
  73. ncbi Toward [18F]-labeled aryltrifluoroborate radiotracers: in vivo positron emission tomography imaging of stable aryltrifluoroborate clearance in mice
    Richard Ting
    Chemistry Department, University of British Columbia, 2036 Main Mall, Vancouver, B C V6T 1Z1, Canada
    J Am Chem Soc 130:12045-55. 2008
    ..This work validates initial claims that boronic esters are potentially useful as readily labeled precursors to [(18)F]-PET reagents...
  74. ncbi Chemoselective hydrazone formation between HYNIC-functionalized peptides and (18)F-fluorinated aldehydes
    Kjerstin Bruus-Jensen
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, D 81675 Munich, Germany
    Nucl Med Biol 33:173-83. 2006
    ....
  75. doi Silicon-based building blocks for one-step 18F-radiolabeling of peptides for PET imaging
    Linjing Mu
    Center for Radiopharmaceutical Science of ETH, PSI and USZ, ETH Honggerberg, D CHAB IPW HCI H427, Wolfgang Pauli Strasse 10, 8093 Zurich, Switzerland
    Angew Chem Int Ed Engl 47:4922-5. 2008
  76. pmc Bone metabolic activity in hyperostosis cranialis interna measured with 18F-fluoride PET
    Jérôme J Waterval
    Department of Otorhinolaryngology and Head and Neck Surgery, Maastricht University Medical Center, PO 5800, 6202 AZ Maastricht, The Netherlands
    Eur J Nucl Med Mol Imaging 38:884-93. 2011
    ..The aim of this study is to compare standardised uptake values (SUVs) at different sites in order to quantify bone metabolism in the affected anatomical regions in HCI patients...
  77. ncbi Biodistribution and catabolism of 18F-labeled N-epsilon-fructoselysine as a model of Amadori products
    Christina Hultsch
    Institute of Radiopharmacy, Research Center Rossendorf, P O Box 51 01 19, D 01314 Dresden, Germany
    Nucl Med Biol 33:865-73. 2006
    ..Therefore, it was concluded that the predominant part of peptide-bound lysine that was fructosylated during food processing is not available for nutrition...
  78. ncbi Synthesis of N-succinimidyl 4-[18F]fluorobenzoate, an agent for labeling proteins and peptides with 18F
    Ganesan Vaidyanathan
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    Nat Protoc 1:1655-61. 2006
    ..18F]SFB remains an optimal reagent for labeling proteins and peptides with 18F because of good conjugation yields and metabolic stability...
  79. pmc Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET
    Emmanuelle Briard
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 52:688-99. 2009
    ..In rat, a low level radiometabolite of intermediate lipophilicity was identified as [18F]2-fluoro-N-(2-phenoxyphenyl)acetamide ([18F]11). [18F]9 is a promising radioligand for future imaging of PBR in living human brain...
  80. ncbi [18F]FEAC and [18F]FEDAC: Two novel positron emission tomography ligands for peripheral-type benzodiazepine receptor in the brain
    Kazuhiko Yanamoto
    Department of Molecular Probes, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, Chiba 263 8555, Japan
    Bioorg Med Chem Lett 19:1707-10. 2009
    ..Small-animal PET scan for a neuroinflammatory rat model showed that the two radioligands had high uptakes of radioactivity in the kainic acid-infused striatum, a brain region where PBR density was increased...
  81. pmc Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor
    Shui Yu Lu
    PET Radiopharmaceutical Sciences, Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892 1003, USA
    Lab Chip 4:523-5. 2004
    ....
  82. ncbi Diagnostic accuracy of [¹⁸F]-fluoro-L-dihydroxyphenylalanine positron emission tomography scan for persistent congenital hyperinsulinism in Japan
    Michiya Masue
    Department of Pediatrics, Kizawa Memorial Hospital, Chubu Medical Center for Prolonged Traumatic Brain Dysfunction, Gifu, Japan
    Clin Endocrinol (Oxf) 75:342-6. 2011
    ..Although [(18)F]DOPA PET is reported to be useful for precisely localizing the focal form of congenital hyperinsulinism, previous reports are mostly from European and North American centres...
  83. ncbi Bone metabolism of residual ridge beneath the denture base of an RPD observed using NaF-PET/CT
    Hanako Suenaga
    Division of Advanced Prosthetic Dentistry, Tohoku University Graduate School of Dentistry, 4 1 Seiryo machi, Aoba ku, Sendai, 980 8575, Japan
    J Prosthodont Res 56:42-6. 2012
    ..However, CT images showed no obvious changes in the bone shape and structure beneath RPD, and CT values both on the control and test sides did not change either...
  84. ncbi The value of [18F]fluoro-2-deoxy-D-glucose positron emission tomography in the selection of patients with stage IIIA-N2 non-small cell lung cancer for combined modality treatment
    C J Hoekstra
    Clinical PET Centre, VU University Medical Centre, PO Box 7057, 1007 MB, Amsterdam, The Netherlands
    Lung Cancer 39:151-7. 2003
    ..These results show that using the conventional staging algorithm a substantial group of patients was understaged. FDG PET improves the selection of patients suitable for CMT...
  85. ncbi In vivo imaging and quantitative analysis of TSPO in rat peripheral tissues using small-animal PET with [18F]FEDAC
    Kazuhiko Yanamoto
    Molecular Imaging Center, National Institute of Radiological Sciences, Inage Ku, Chiba, Japan
    Nucl Med Biol 37:853-60. 2010
    ..Here, using small-animal PET with [(18)F]FEDAC, we performed TSPO imaging and quantitative analysis of TSPO binding in rat peripheral tissues...
  86. pmc Assessment of successful incorporation of cages after cervical or lumbar intercorporal fusion with [(18)F]fluoride positron-emission tomography/computed tomography
    Dorothee R Fischer
    Department of Nuclear Medicine, University Hospital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Eur Spine J 20:640-8. 2011
    ....
  87. ncbi The diagnostic and prognostic effectiveness of F-18 sodium fluoride PET-CT in detecting bone metastases for hepatocellular carcinoma patients
    Ruoh Fang Yen
    Department of Nuclear Medicine, National Taiwan University College of Medicine, National Taiwan University Hospital, Taipei, Taiwan
    Nucl Med Commun 31:637-45. 2010
    ....
  88. ncbi Femoral head viability following resurfacing arthroplasty. A clinical positron emission tomography study
    Gösta Ullmark
    Department of Orthopedics Gävle hospital and Centre for Research and Development Uppsala University County Council of Gävleborg, Sweden
    Hip Int 21:66-70. 2011
    ..This was seen following both posterior and antero lateral approaches. Fluoride PET is a sensitive and useful method for evaluating bone metabolism following HR...
  89. ncbi Synthesis and in vitro evaluation of [18F]fluoroethyl triazole labelled [Tyr3]octreotate analogues using click chemistry
    Lisa Iddon
    GE Healthcare, MDx Discovery, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK
    Bioorg Med Chem Lett 21:3122-7. 2011
    ..As well as ease of synthesis, in vitro binding to the pancreatic tumour AR42J cells showed that both FET-G-TOCA and FET-βAG-TOCA have high affinity for the somatostatin receptor with IC(50) of 4.0±1.4, and 1.6±0.2 nM, respectively...
  90. pmc Biodistribution, pharmacokinetics and metabolism of interleukin-1 receptor antagonist (IL-1RA) using [¹⁸F]-IL1RA and PET imaging in rats
    C Cawthorne
    Wolfson Molecular Imaging Centre, University of Manchester, Manchester, UK
    Br J Pharmacol 162:659-72. 2011
    ..Here we illustrate the potential of PET imaging in a preclinical study of the biodistribution and metabolism of ¹⁸F-labelled IL-1 receptor antagonist ([¹⁸F]IL-1RA) using a novel [¹⁸F]-radiolabelling technique...
  91. ncbi Microfluidic approach for fast labeling optimization and dose-on-demand implementation
    Giancarlo Pascali
    Radiopharmacy Department, Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy
    Nucl Med Biol 37:547-55. 2010
    ..Microfluidic represents an innovative approach, owing to its potential to increase radiochemical productivity in terms of yields, time reduction, precursor consumption and flexible experimental planning...
  92. ncbi Radionuclide studies of bone metabolism: do bone uptake and bone plasma clearance provide equivalent measurements of bone turnover?
    Glen M Blake
    Division of Imaging Sciences, King s College London, Guy s Campus, London, UK
    Bone 49:537-42. 2011
    ..Similar effects may occur with other therapies that have a large enough effect on bone metabolism. In these circumstances changes in bone plasma clearance give a truer impression of response to treatment than those in SUV or uptake...
  93. ncbi The diagnosis of ectopic focal hyperinsulinism of infancy with [18F]-dopa positron emission tomography
    Khalid Hussain
    London Center for Pediatric Endocrinology and Metabolism, Hospital for Children National Health Service Trust, London WC1N 3JH, United Kingdom
    J Clin Endocrinol Metab 91:2839-42. 2006
    ..The focal form of the disease can be cured if the focal lesion can be localized accurately and completely resected with surgery...
  94. ncbi Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease
    Kim Serdons
    Faculty of Pharmaceutical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    J Med Chem 52:1428-37. 2009
    ..The preliminary results strongly suggest that this new fluorinated compound is a promising candidate as an Abeta plaque imaging agent for the study of patients with AD...
  95. ncbi Rapid aqueous [18F]-labeling of a bodipy dye for positron emission tomography/fluorescence dual modality imaging
    Zibo Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Chem Commun (Camb) 47:9324-6. 2011
    ..This radiolabeled dye, whose biodistribution and clearance has been studied in mice, is stable in vivo and can be used as a positron emission tomography/fluorescence dual modality imaging agent...
  96. ncbi Labeling strategies with F-18 for positron emission tomography imaging
    Yonghong Gu
    Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, P R China
    Med Chem 7:334-44. 2011
    ..This review summarizes the strategies and recent developments in the fluorine-18 labeling of probes for PET imaging. Problems and issues relating to the practical production of fluorine-18 currently in widespread use are also discussed...
  97. ncbi Localization of trapping of 6-[(18)F]fluoro-L-m-tyrosine, an aromatic L-amino acid decarboxylase tracer for PET
    W D Brown
    Department of Radiology, University of Wisconsin Madison, USA
    Synapse 34:111-23. 1999
    ..This may be especially important in diseases or experimental states in which dopaminergic neurons are selectively reduced, and may allow for the study of nondopaminergic neuronal systems in vivo with this tracer...
  98. ncbi 6-fluoroDOPA metabolism in rat striatum: time course of extracellular metabolites
    O T DeJesus
    Department of Medical Physics, University of Wisconsin Medical School, 1530 Medical Sciences Center, 1300 University Avenue, Madison, WI 53706, USA
    Brain Res 877:31-6. 2000
    ..These metabolic steps and their role in tracer kinetics are, thus, important factors to consider in ascribing physiologic significance to PET-derived measures...
  99. ncbi Comparison of two methods for the analysis of [18F]6-fluoro-L-m-tyrosine PET data
    Jamie L Eberling
    Center for Functional Imaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
    Neuroimage 23:358-63. 2004
    ..These findings suggest that a simple ratio approach to analyzing FMT PET data may be a useful alternative to a kinetic approach especially for clinical applications...
  100. ncbi 11C/ 18F-choline PET or 11C/18F-acetate PET in prostate cancer: may a choice be recommended?
    Cristina Nanni
    Eur J Nucl Med Mol Imaging 34:1704-5. 2007
  101. pmc Molecular imaging: what can be used today
    P L Jager
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center, Groningen, The Netherlands
    Cancer Imaging 5:S27-32. 2005
    ..As an example, molecular imaging methods that target the HER2 receptor and somatostatin receptor are described...

Research Grants66

  1. PET Imaging of the Pancreas in Murine Models of Diabetes
    Paige Clark; Fiscal Year: 2005
    ..The method could also be useful in evaluating the function of pancreatic transplants and successful engraftment of transplanted progenitor or beta cells. ..
  2. F-18 FDG Peptides for Pretargeted PET Imaging of Pancrea
    William McBride; Fiscal Year: 2005
    ..It would also support the preclinical targeting, synthesis of new peptide derivatives to optimize excretion, serum stablity and safety studies in animals that would be needed before this agent goes into the clinic. ..
  3. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2006
    ..abstract_text> ..
  4. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  5. Small Animal PET (microPET)
    JOGESH MUKHERJEE; Fiscal Year: 2007
    ..abstract_text> ..
  6. Radiolabeled Probes for Imaging Caspase 3 Activation
    Robert Mach; Fiscal Year: 2008
    ..abstract_text> ..
  7. PET Imaging of Hypoxia with EF5
    Cameron Koch; Fiscal Year: 2009
    ..In summary, the aims of this grant will extend and advance our overall laboratory interest in quantifying the degree and extent of clinically relevant hypoxia in the tumor microenvironment. ..
  8. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  9. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
    ....
  10. PET IMAGING OF DRUG KINETICS AND PATHWAYS
    Anthony Shields; Fiscal Year: 2002
    ..Our proposed study of [F-18]FAU with PET will provide information on the biodistribution of this new therapeutic agent and may provide a way to image tumor TS activity and proliferation. ..
  11. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  12. IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVING
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
  13. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  14. Positron Emission Tomography in Prostate Cancer
    Farrokh Dehdashti; Fiscal Year: 2008
    ..PET may also contribute significant prognostic information that may affect the decision to administer early adjuvant therapy to delay or prevent recurrence. [unreadable] [unreadable]..
  15. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  16. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  17. DEVELOPMENT OF D3 ANTAGONISTS TO TREAT COCAINE ADDICTION
    Robert Mach; Fiscal Year: 2002
    ..In addition, this research will result in the development of radiolabeled probes for studying both the function of D3 receptors in the CNS and the alteration in D3 receptor density thatoccurs as a consequence of cocaine abuse. ..
  18. Early Prediction of Pathological Response of Chemoradiotherapy with FLT PET
    KS CLIFFORD CHAO; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  19. Predicting Radiation Response by Tumor pO2
    Cameron Koch; Fiscal Year: 2006
    ..DDFP may thus be the first PFC emulsion practical and safe for use in multifraction clinical regimens. ..
  20. Labeled Thymidine -- Development as A PET Imaging Agent
    Anthony Shields; Fiscal Year: 2008
    ..Our ultimate goal is to demonstrate that this approach is useful in evaluating both experimental and routine clinical treatment. ..
  21. PET Imaging of Breast Cancer via Sigma-2 Receptors
    Robert Mach; Fiscal Year: 2006
    ..abstract_text> ..
  22. Vascular and Metabolic Mechanisms in Alzheimer's Disease
    Robert Mach; Fiscal Year: 2009
    ..Through the use of the unique resources and personnel at Washington University Medical Center, we have the opportunity to provide answers to important clinical and mechanistic questions in AD. ..
  23. HYPOXIC IMAGING GUIDED INTENSITY MODULATED RADIOTHERAPY
    KS CLIFFORD CHAO; Fiscal Year: 2003
    ..They will test the hypothesis by performing multiple Cu-60 ATSM PET scans during the course of irradiation to understand the spatial evolution of hypoxic tumor. ..
  24. Dopamine D2 Selective Imaging Agents
    Robert Mach; Fiscal Year: 2008
    ..A secondary goal of this project is to develop an iodine-125 labeled radiotracer for in vitro binding studies of the D2 receptor. ..
  25. Dopamine D3 Receptor Imaging Agents for PET and SPECT
    Robert Mach; Fiscal Year: 2006
    ..A secondary goal of this project is to develop an iodine-125 labeled radiotracer for in vitro binding studies of the D3 receptor. ..
  26. PET Radiotracers for Imaging Apoptosis
    Robert Mach; Fiscal Year: 2004
    ..If successful, the research described in this research proposal will provide a PET-based imaging procedure for measuring apoptosis that will be of tremendous value to the PET research community. ..
  27. Oxidative Damage to DNA Repair Pathways
    Cameron Koch; Fiscal Year: 2006
    ..Specific Aim 3 will investigate other aspects of DNA repair and DNA structural organization to determine their sensitivity to redox regulation. ..
  28. Mechanisms of Axonal Sprouting After Stroke
    STANLEY CARMICHAEL; Fiscal Year: 2007
    ..These experiments will identify neuronal growth programs after stroke, and Iocal inhibitory molecules, and provide an understanding of the mechanisms of regeneration in the adult brain. ..
  29. PET Amyloid Plaque Imaging in Late Life Depression
    Yvette Sheline; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  30. Research Training in Nuclear Molecular Imaging
    Alan Fischman; Fiscal Year: 2007
    ..abstract_text> ..
  31. Phosphoinositide and Inositol Polyphosphate Probes
    Glenn Prestwich; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  32. Dopamine D2/D3 Receptor Agonists for PET Imaging
    JOGESH MUKHERJEE; Fiscal Year: 2010
    ..Finally PET studies will be carried out in monkeys with these agents to demonstrate HA-state binding and receptor subtype selectivity. ..
  33. New PET radioligand for the serotonin transporter
    Yiyun Huang; Fiscal Year: 2007
    ..Introduction of [18F]AFM would constitute the first PET tracer for the SERT that can be prepared in a central facility and distributed to various sites for clinical imaging purposes. ..
  34. Vascular Depression: Longitudinal Followup
    Yvette I Sheline; Fiscal Year: 2010
    ..The proposal will provide important new data on neuroradiologic and neuropsychological factors contributing to recurrent or chronic depression in older individuals. ..
  35. Lung Cancer Prognosis: FLT PET and DNA Hypermethylation
    Hubert Vesselle; Fiscal Year: 2009
    ..This prognostic information will permit individualization and optimization of therapy for the 41,000 early stage NSCLC patients undergoing surgical resection each year in the United States. ..
  36. FLT PET to Plan the Best Therapy for Lung Cancer
    Hubert Vesselle; Fiscal Year: 2008
    ..At the conclusion of this study, the insight gained in the response of stage III NSCLCs will allow clinicians to plan the best therapy for these patients. [unreadable] [unreadable]..
  37. Utility of [F-18] fluoroDOPA for neonatal hyperinsulism: A Phase II
    Chaitanya Divgi; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  38. Signaling Pathways that Determine Ewings Sarcoma Outcome
    Jeffrey Toretsky; Fiscal Year: 2008
    ..Clearly, if PTPL1 is validated as a supportive oncoprotein and the pathways modulated by PTPL1 are identified, patients with many other tumors that rely on IGF-IR signaling including breast carcinoma could benefit from our findings. ..
  39. Guanfacine Treatment for Prefrontal Cognitive Dysfunction in Elderly Subjects
    Christopher H van Dyck; Fiscal Year: 2010
    ..This Pilot Clinical Trial will provide essential preliminary data for a subsequent full-scale trial of guanfacine for prefrontally-mediated cognitive dysfunction in elderly subjects. ..
  40. NOVEL MARKERS FOR IMAGING GENE EXPRESSION IN VIVO USING MRI
    ERIC AHRENS; Fiscal Year: 2008
    ..Towards this goal, our project will develop new technologies to visualize gene expression in vivo using conventional magnetic resonance imaging (MRI) scanners. ..
  41. Simultaneous PET imaging of rCBF and dopamine release
    ALEXANDER CONVERSE; Fiscal Year: 2006
    ....
  42. Blood-brain barrier gene delivery in knock-out mice.
    EAIN CORNFORD; Fiscal Year: 2005
    ..abstract_text> ..
  43. MicroPET and NIR Fluorescence Imaging Tumor Angiogenesis
    Xiaoyuan Chen; Fiscal Year: 2004
    ..All the results obtained here will be used for future application of a R01 type grant. ..
  44. DOPAMINE AND GABA IMAGING IN SCHIZOPHRENIA
    Lawrence Kegeles; Fiscal Year: 2004
    ..abstract_text> ..
  45. Evaluation of Presynaptic Calcium Channels In Vivo
    Daniel Silverman; Fiscal Year: 2003
    ..A possible peripheral benefit of this work lies in its potential to bring us closer to an effective CNS delivery system for calcium channel antagonists which are under clinical development as therapeutic agents. ..
  46. DEVELOPMENT OF A PET RADIOTRACER FOR SIGMA-1 RECEPTOR
    Rikki Waterhouse; Fiscal Year: 2002
    ....
  47. SQUALENE AND OXIDOSQUALENE CYCLASES
    Glenn Prestwich; Fiscal Year: 2002
    ....
  48. ESTROGENIC SUBSTANCE DETECTION BY A MODIFIED NANOBALANCE
    LINDA LUCK; Fiscal Year: 2002
    ..This application offers the development of a new biological analytic technique that could monitor estrogenic substances both in the environment and in food products. ..
  49. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2001
    ..Finally, [11C]- and [18F]-labeled polar derivatives of the psychostimulant methcathinone will be synthesized as potential NET markers and their in vitro NET affinities determined as the cloned human NET transporter. ..
  50. Thiol-Reactive Crosslinkers for Biomaterials
    Glenn Prestwich; Fiscal Year: 2004
    ..Fourth, these new materials will be evaluated for cytocompatibility and cell growth in vitro with murine fibroblasts. Finally, selected materials will be seeded with fibroblasts and injected into nude mice for in vivo tissue generation. ..
  51. Akt Inhibitors to Treat Ewing's Sarcoma
    Jeffrey Toretsky; Fiscal Year: 2005
    ..Our findings from this Phase I Sun will hopefully lead to a key compound that can be further developed in a Phase II STTR ultimately leading to clinical trials in patients with ESFT. ..
  52. Imaging of O6-Alkylguanine-DNA Alkyltransferase
    Ganesan Vaidyanathan; Fiscal Year: 2005
    ..In summary, this proposal seeks to determine whether the development of a suitable agent for the imaging of tumor AGT will facilitate chemotherapy planning, thereby improving the outcome of alkylator chemotherapy. ..
  53. Development and Applications of Novel SERT PET Ligands
    Mark Goodman; Fiscal Year: 2006
    ..Once SERT binding is determined in depressed patients, we will be able to assess the relationship of SERT binding and treatment response to SSRIs. ..
  54. Biacore T100
    Jeffrey Toretsky; Fiscal Year: 2006
    ..These enhanced capabilities of the T100 will allow projects investigating many types of biologic processes to advance. ..
  55. Conference on the Diagnosis of Multiple System Atrophy
    Sid Gilman; Fiscal Year: 2006
    ..This conference will assist with early diagnosis by developing new guidelines for diagnosis using newly available imaging and neuropathological criteria. [unreadable] [unreadable] [unreadable]..
  56. COGNITION AND ESTROGEN IN MIDDLE-AGED FEMALE MONKEYS
    Mary Lou Voytko; Fiscal Year: 2003
    ..The findings from these novel experiments in middle-aged monkeys will significantly advance our understanding of the effects of different ovarian hormone therapies on cognitive and neurobiological profiles of primates. ..
  57. PET, APOE & The Preclinical Course of Alzheimer Disease
    Eric Reiman; Fiscal Year: 2006
    ..abstract_text> ..
  58. Neuroimaging in Depression Treatment Studies
    Yvette Sheline; Fiscal Year: 2006
    ..abstract_text> ..
  59. PREDICTING TUMOR RESPONSE TO FLUOROURACIL WITH PET
    James Bading; Fiscal Year: 2002
    ..Multiple regression analysis will be used to evaluate combination of parameters derived from PET and ex vivo TS assays as predictors of tumor response. ..
  60. Optical Resources for Molecular Imaging Center
    James Bading; Fiscal Year: 2003
    ..PET techniques developed in preclinical studies with the support of optical imaging should translate more or less directly into clinical applications. ..
  61. Androgen Receptor Mediated Detection of Cancer Using PET
    Pradeep Garg; Fiscal Year: 2007
    ..This technique would also aid clinicians in planning and selecting the appropriate treatment regimen. ..
  62. Diagnosis of IM Nodal Metastases in Breast Cancer
    David Mankoff; Fiscal Year: 2004
    ..This diagnostic study will provide important data to direct future internal mammary radiotherapy trials. ..
  63. IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCER
    David Mankoff; Fiscal Year: 2006
    ..In this amended application, we focus on recent progress that has strengthened our preliminary data and further supports our proposed investigations of the biology of advanced breast cancer and its relationship to therapeutic response. ..
  64. Development of PET radioligands for cerebral cannabinoid receptor (CB1)
    ANDREW HORTI; Fiscal Year: 2008
    ....
  65. Cytochrome Oxidase Polymorphisms in Aging
    Russell Swerdlow; Fiscal Year: 2007
    ..This work could help explain why complex genetic diseases are sometimes associated with mitochondrial dysfunction. ..