radioisotopes

Summary

Summary: Isotopes that exhibit radioactivity and undergo radioactive decay. (From Grant & Hackh's Chemical Dictionary, 5th ed & McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Top Publications

  1. ncbi Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancer
    E C Dijkers
    Department of Hospital and Clinical Pharmacy, University of Groningen, Groningen, The Netherlands
    Clin Pharmacol Ther 87:586-92. 2010
  2. ncbi An overview of targeted alpha therapy
    Young Seung Kim
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892 1002, USA
    Tumour Biol 33:573-90. 2012
  3. pmc Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 10:177-86, 1-3. 2011
  4. pmc Positive progress in immunoPET--not just a coincidence
    Katelyn E McCabe
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Cancer Biother Radiopharm 25:253-61. 2010
  5. ncbi Development and characterization of clinical-grade 89Zr-trastuzumab for HER2/neu immunoPET imaging
    Eli C F Dijkers
    Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 50:974-81. 2009
  6. pmc Cerenkov luminescence imaging of medical isotopes
    Alessandro Ruggiero
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1123-30. 2010
  7. pmc Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6
    Michael R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Nucl Med 49:30-8. 2008
  8. ncbi Geomycology: biogeochemical transformations of rocks, minerals, metals and radionuclides by fungi, bioweathering and bioremediation
    Geoffrey M Gadd
    Division of Environmental and Applied Biology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Mycol Res 111:3-49. 2007
  9. ncbi Pharmacokinetics, micro-SPECT/CT imaging and therapeutic efficacy of (188)Re-DXR-liposome in C26 colon carcinoma ascites mice model
    Liang Cheng Chen
    Institute of Nuclear Energy Research, Taoyuan, Taiwan
    Nucl Med Biol 35:883-93. 2008
  10. pmc Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
    Ekaterina Dadachova
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Med 3:e427. 2006

Detail Information

Publications299 found, 100 shown here

  1. ncbi Biodistribution of 89Zr-trastuzumab and PET imaging of HER2-positive lesions in patients with metastatic breast cancer
    E C Dijkers
    Department of Hospital and Clinical Pharmacy, University of Groningen, Groningen, The Netherlands
    Clin Pharmacol Ther 87:586-92. 2010
    ..PET scanning after administration of (89)Zr-trastuzumab at appropriate doses allows visualization and quantification of uptake in HER2-positive lesions in patients with metastatic breast cancer...
  2. ncbi An overview of targeted alpha therapy
    Young Seung Kim
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, NCI, NIH, 10 Center Drive, Building 10, Rm B3B69, Bethesda, MD 20892 1002, USA
    Tumour Biol 33:573-90. 2012
    ..Furthermore, better chelation and labeling methods with the improvements of isotope delivery, targeting vehicles, molecular targets, and identification of appropriate clinical applications are still required...
  3. pmc Intraoperative imaging of positron emission tomographic radiotracers using Cerenkov luminescence emissions
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 10:177-86, 1-3. 2011
    ..Overall, these results strongly support the continued development of CLI as a preclinical and possible clinical tool for use in molecular imaging and surgical procedures for accurately defining tumor margins...
  4. pmc Positive progress in immunoPET--not just a coincidence
    Katelyn E McCabe
    David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Cancer Biother Radiopharm 25:253-61. 2010
    ..Antibody-based PET probes constitute a valuable class of molecular imaging agents, and the progress made preclinically should expedite the transition of these targeted diagnostics to clinical applications...
  5. ncbi Development and characterization of clinical-grade 89Zr-trastuzumab for HER2/neu immunoPET imaging
    Eli C F Dijkers
    Department of Hospital and Clinical Pharmacy, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Nucl Med 50:974-81. 2009
    ..The PET radiopharmaceutical (89)Zr-trastuzumab was compared with the SPECT tracer (111)In-trastuzumab, which we have tested in the clinic already...
  6. pmc Cerenkov luminescence imaging of medical isotopes
    Alessandro Ruggiero
    Nuclear Medicine Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    J Nucl Med 51:1123-30. 2010
    ..Here, we report the use of the inherent optical emissions from the decay of radiopharmaceuticals for Cerenkov luminescence imaging (CLI) of tumors in vivo and correlate the results with those obtained from concordant immuno-PET studies...
  7. pmc Clinical experience with alpha-particle emitting 211At: treatment of recurrent brain tumor patients with 211At-labeled chimeric antitenascin monoclonal antibody 81C6
    Michael R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Nucl Med 49:30-8. 2008
    ..The main goal of this study was to investigate the feasibility and safety of this approach in patients with recurrent malignant brain tumors...
  8. ncbi Geomycology: biogeochemical transformations of rocks, minerals, metals and radionuclides by fungi, bioweathering and bioremediation
    Geoffrey M Gadd
    Division of Environmental and Applied Biology, College of Life Sciences, University of Dundee, Dundee DD1 4HN, UK
    Mycol Res 111:3-49. 2007
    ....
  9. ncbi Pharmacokinetics, micro-SPECT/CT imaging and therapeutic efficacy of (188)Re-DXR-liposome in C26 colon carcinoma ascites mice model
    Liang Cheng Chen
    Institute of Nuclear Energy Research, Taoyuan, Taiwan
    Nucl Med Biol 35:883-93. 2008
    ..Therefore, intraperitoneal administration of novel (188)Re-DXR-liposome could provide a benefit and promising strategy for delivery of passive nanotargeted bimodality radiochemotherapeutics in oncology applications...
  10. pmc Targeted killing of virally infected cells by radiolabeled antibodies to viral proteins
    Ekaterina Dadachova
    Albert Einstein College of Medicine, Bronx, New York, United States of America
    PLoS Med 3:e427. 2006
    ..The aim of this proof-of-principle study was to demonstrate the efficacy of a therapeutic strategy of targeting and eliminating HIV-1-infected cells with radiolabeled antibodies specific to viral proteins in vitro and in vivo...
  11. ncbi Early radiation survey of Iitate village, which was heavily contaminated by the Fukushima Daiichi accident, conducted on 28 and 29 March 2011
    Tetsuji Imanaka
    Research Reactor Institute, Kyoto University, Kumatori cho, Osaka, Japan
    Health Phys 102:680-6. 2012
    ..At this location, the cumulative exposure would reach 50 mGy in the middle of May 2011...
  12. ncbi Radiation dose estimation by tooth enamel EPR dosimetry for residents of Dolon and Bodene
    Kassym Zhumadilov
    Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
    J Radiat Res 47:A47-53. 2006
    ..1+/-45.5 mGy before 1949 while the younger population received up to about 100 mGy with an average value of 11.5+/-37.7 mGy...
  13. ncbi Production of 177Lu at the new research reactor FRM-II: Irradiation yield of 176Lu(n,gamma)177Lu
    Z Dvorakova
    Institut für Radiochemie der Technischen Universität München, D 85748 Garching, Germany
    Appl Radiat Isot 66:147-51. 2008
    ..The comparison of theoretically calculated and experimentally determined yield for Lu176(n,gamma)Lu177 reaction is presented...
  14. ncbi Radioactivity from Fukushima Dai-ichi in air over Europe; part 2: what can it tell us about the accident?
    G Kirchner
    German Federal Office for Radiation Protection, Kopenicker Allee 120 130, 10318 Berlin, Germany
    J Environ Radioact 114:35-40. 2012
    ..The caesium activity ratios indicate emissions from the core of unit 4 which had been unloaded into the fuel storage pool prior to the accident...
  15. ncbi Development and characterization of 89Zr-labeled panitumumab for immuno-positron emission tomographic imaging of the epidermal growth factor receptor
    Albert J Chang
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 12:17-27. 2013
    ..Biodistribution studies confirmed the results from the imaging studies. (89)Zr-panitumumab imaging of EGFR-positive tumors demonstrated levels of radiotracer uptake associated with EGFR expression...
  16. ncbi Evaluation of beta-absorbed fractions in a mouse model for 90Y, 188Re, 166Ho, 149Pm, 64Cu, and 177Lu radionuclides
    William H Miller
    Nuclear Science and Engineering Institute, University of Missouri, Columbia, MO 65211, USA
    Cancer Biother Radiopharm 20:436-49. 2005
    ....
  17. pmc Sequential cytarabine and alpha-particle immunotherapy with bismuth-213-lintuzumab (HuM195) for acute myeloid leukemia
    Todd L Rosenblat
    Department of Medicine and the Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Clin Cancer Res 16:5303-11. 2010
    ..This phase I/II trial was conducted to determine the maximum tolerated dose (MTD) and antileukemic effects of (213)Bi-lintuzumab, the first targeted α-emitter, after partially cytoreductive chemotherapy...
  18. pmc Quantitative modeling of Cerenkov light production efficiency from medical radionuclides
    Bradley J Beattie
    Medical Physics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America
    PLoS ONE 7:e31402. 2012
    ..We also propose a simple means of using this information to calibrate high sensitivity luminescence imaging systems and show evidence suggesting that this calibration may be more accurate than methods in routine current use...
  19. ncbi Intravesical alpha-radioimmunotherapy with 213Bi-anti-EGFR-mAb defeats human bladder carcinoma in xenografted nude mice
    Birgit Pfost
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    J Nucl Med 50:1700-8. 2009
    ....
  20. ncbi Mechanisms of cell sensitization to alpha radioimmunotherapy by doxorubicin or paclitaxel in multiple myeloma cell lines
    Stephane Supiot
    Institut National de la Sante et de la Recherche Medicale U601, Moncousu, Nantes, France
    Clin Cancer Res 11:7047s-7052s. 2005
    ....
  21. pmc Clinical effects of transcatheter hepatic arterial embolization with holmium-166 poly(L-lactic acid) microspheres in healthy pigs
    M A D Vente
    Department of Nuclear Medicine, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Eur J Nucl Med Mol Imaging 35:1259-71. 2008
    ..The aim of this study is to evaluate the toxicity of holmium-166 poly(L-lactic acid) microspheres administered into the hepatic artery in pigs...
  22. ncbi An alumina ceramic target vessel for the remote production of metallic radionuclides by in situ target dissolution
    Kotaro Nagatsu
    Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage, Chiba 263 8555, Japan
    Nucl Med Biol 39:1281-5. 2012
    ..In this study, we demonstrated an in situ target processing concept for automated metallic radionuclide production without the use of any robotic device...
  23. pmc PET and MRI of metastatic peritoneal and pulmonary colorectal cancer in mice with human epidermal growth factor receptor 1-targeted 89Zr-labeled panitumumab
    Tapan K Nayak
    Radioimmune and Inorganic Chemistry Section, Radiation Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    J Nucl Med 53:113-20. 2012
    ..The utility of PET and MRI using (89)Zr-panitumumab to assess the status of HER1 in distant metastases with different metastasis models is presented in this study...
  24. pmc Standardized methods for the production of high specific-activity zirconium-89
    Jason P Holland
    Memorial Sloan Kettering Cancer Center, Department of Radiology, New York, NY 10065, USA
    Nucl Med Biol 36:729-39. 2009
    ..The detailed methods described can be easily translated to other radiochemistry facilities and will facilitate the use of (89)Zr in both basic science and clinical investigations...
  25. ncbi Site-specifically 89Zr-labeled monoclonal antibodies for ImmunoPET
    Jeff N Tinianow
    Genentech Research and Early Development, Genentech Inc, South San Francisco, CA 94080, USA
    Nucl Med Biol 37:289-97. 2010
    ..The in vitro stability and in vivo imaging properties of site-specifically radiolabeled (89)Zr-Df-thio-trastuzumab conjugates were investigated...
  26. ncbi Arrival time and magnitude of airborne fission products from the Fukushima, Japan, reactor incident as measured in Seattle, WA, USA
    J Diaz Leon
    Department of Physics and Center for Experimental Nuclear Physics and Astrophysics, University of Washington, Seattle, WA 98195, USA
    J Environ Radioact 102:1032-8. 2011
    ..The highest detected activity from radionuclides attached to particulate matter amounted to 4.4 ± 1.3 mBq m(-3) of (131)I on 19-20 March...
  27. ncbi Tumour anti-vascular alpha therapy: a mechanism for the regression of solid tumours in metastatic cancer
    Barry J Allen
    Phys Med Biol 52:L15-9. 2007
    ..This effect depends on the expression of targeted receptors by capillary pericytes and contiguous cancer cells, and on the short-range and high-energy transfer of alpha radiation...
  28. ncbi In vivo biodistribution and accumulation of 89Zr in mice
    Diane S Abou
    Department of Radiology, Radiochemistry Service, Memorial Sloan Kettering Cancer Center, Box 16, New York, NY 10065, USA
    Nucl Med Biol 38:675-81. 2011
    ..A special focus is also given regarding the quality of (89)Zr bone accumulation...
  29. ncbi Air radioactivity levels following the Fukushima reactor accident measured at the Laboratoire Souterrain de Modane, France
    P Loaiza
    Laboratoire Souterrain de Modane, CNRS CEA, 1125 route de Bardonnèche, 73500 Modane, France
    J Environ Radioact 114:66-70. 2012
    ..The results of the radioactivity concentration levels in grass and mushrooms exposed to the air in the Modane region were also measured. Activity concentrations of (131)I of about 100 mBq/m(2) were found in grass...
  30. pmc Neoadjuvant peptide receptor radionuclide therapy for an inoperable neuroendocrine pancreatic tumor
    Daniel Kaemmerer
    Department of General and Visceral Surgery, Zentralklinik Bad Berka, 99437 Bad Berka, Germany
    World J Gastroenterol 15:5867-70. 2009
    ..Follow-up for eighteen months revealed a complete remission. This is the first report on neoadjuvant PRRT in a neuroendocrine neoplasm with subsequent successful complete resection...
  31. ncbi (89)Zr as a PET surrogate radioisotope for scouting biodistribution of the therapeutic radiometals (90)Y and (177)Lu in tumor-bearing nude mice after coupling to the internalizing antibody cetuximab
    Lars R Perk
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 46:1898-906. 2005
    ..Cetuximab was selected as a model mAb because it abundantly internalizes after binding to the epidermal growth factor receptor...
  32. ncbi Implementation of 89Zr production and in vivo imaging of B-cells in mice with 89Zr-labeled anti-B-cell antibodies by small animal PET/CT
    Martin Walther
    Institute of Radiopharmacy, Helmholtz Zentrum Dresden Rossendorf, Germany
    Appl Radiat Isot 69:852-7. 2011
    ..PET measurements showed binding of (89)Zr-labeled anti-B cell antibodies in tissues with high frequencies of B cells, i.e. in spleen and lymph nodes...
  33. pmc Radionuclide carriers for targeting of cancer
    Stavroula Sofou
    Laboratory for Drug Delivery Systems, Othmer Jacobs Department of Chemical and Biological Engineering, Polytechnic University, Brooklyn, NY 11201, USA
    Int J Nanomedicine 3:181-99. 2008
    ..It is expected that the current emphasis on multidisciplinary approaches for exploring such therapeutic directions should enable internal radiotherapy to reach its full potential...
  34. ncbi Auger radiation targeted into DNA: a therapy perspective
    Franz Buchegger
    Service of Nuclear Medicine, University Hospital of Lausanne CHUV, Rue du Bugnon 46, 1011 Lausanne, Switzerland
    Eur J Nucl Med Mol Imaging 33:1352-63. 2006
    ..The latter include hormones, peptides, halogenated nucleotides, oligonucleotides and internalising antibodies...
  35. ncbi Decay data for internal and external dose assessment
    Michael G Stabin
    Department of Radiology and Radiological Sciences, Vanderbilt University, Nashville, TN 37232 2675, USA
    Health Phys 83:471-5. 2002
    ..These recently extracted data provide an update on previously published decay data values in a form readily accessible by many users worldwide...
  36. ncbi High-linear energy transfer (LET) alpha versus low-LET beta emitters in radioimmunotherapy of solid tumors: therapeutic efficacy and dose-limiting toxicity of 213Bi- versus 90Y-labeled CO17-1A Fab' fragments in a human colonic cancer model
    T M Behr
    Department of Nuclear Medicine, Georg August University, Gottingen, Germany
    Cancer Res 59:2635-43. 1999
    ..Due to its short physical half-life, 213Bi appears to be especially suitable for use in conjunction with fast-clearing fragments...
  37. ncbi Radioembolization with yttrium-90 microspheres: a state-of-the-art brachytherapy treatment for primary and secondary liver malignancies: part 3: comprehensive literature review and future direction
    Riad Salem
    Department of Radiology, Robert H Lurie Comprehensive Cancer Center, 676 North St Clair, Suite 800, Chicago, IL 60611, USA
    J Vasc Interv Radiol 17:1571-93. 2006
    ..A comprehensive review of the entire available literature dating from the early 1960s is presented, as is a discussion of the possibilities for future research with use of radioembolization as a platform...
  38. ncbi Therapy of metastatic bone pain
    A N Serafini
    Division of Nuclear Medicine, Department of Radiology, University of Miami/Sylvester Comprehensive Cancer Center/Jackson Memorial Medical Center, Miami, Florida 33101, USA
    J Nucl Med 42:895-906. 2001
    ....
  39. pmc p-Isothiocyanatobenzyl-desferrioxamine: a new bifunctional chelate for facile radiolabeling of monoclonal antibodies with zirconium-89 for immuno-PET imaging
    Lars R Perk
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 37:250-9. 2010
    ..To enable widespread use of (89)Zr-immuno-PET, we now introduce the novel BFC p-isothiocyanatobenzyl-desferrioxamine B (Df-Bz-NCS) and compare its performance in (89)Zr-immuno-PET with the reference BFC TFP-N-sucDf...
  40. ncbi MIRD Pamphlet No. 22 (abridged): radiobiology and dosimetry of alpha-particle emitters for targeted radionuclide therapy
    George Sgouros
    Department of Radiology and Radiological Science, School of Medicine, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 51:311-28. 2010
    ..The objective of this work is to review those aspects of the field that are pertinent to targeted alpha-particle emitter therapy and to provide guidance and recommendations for human alpha-particle emitter dosimetry...
  41. ncbi Bone marrow dosimetry using blood-based models for radiolabeled antibody therapy: a multiinstitutional comparison
    Barry W Wessels
    Department of Radiation Oncology, Case Western Reserve University, Cleveland, Ohio
    J Nucl Med 45:1725-33. 2004
    ..Differences in dose estimates associated with starting assumptions and the exact implementation of the AAPM/Sgouros calculation methodology used by the source institutions and the central facility were quantified and compared...
  42. ncbi Unconventional nuclides for radiopharmaceuticals
    Jason P Holland
    Radiochemistry Service, Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Mol Imaging 9:1-20. 2010
    ..In particular, the properties and safety considerations associated with the increasingly prevalent PET nuclides 64Cu, 68Ga, 86Y, 89Zr, and 124I are discussed...
  43. ncbi Molecular imaging in living subjects: seeing fundamental biological processes in a new light
    Tarik F Massoud
    The Crump Institute for Molecular Imaging, David Geffen School of Medicine at University of California at Los Angeles, Los Angeles, California 90095, USA
    Genes Dev 17:545-80. 2003
  44. ncbi Targeted alpha particle immunotherapy for myeloid leukemia
    Joseph G Jurcic
    Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Medical College of Cornell University, New York, NY 10021, USA
    Blood 100:1233-9. 2002
    ..This study demonstrates the safety, feasibility, and antileukemic effects of (213)Bi-HuM195, and it is the first proof-of-concept for systemic targeted alpha particle immunotherapy in humans...
  45. ncbi Disparity between in vivo EGFR expression and 89Zr-labeled cetuximab uptake assessed with PET
    Hugo J W L Aerts
    Department of Radiation Oncology MAASTRO, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    J Nucl Med 50:123-31. 2009
    ..To this end, we have developed and validated a novel probe using cetuximab labeled with the long-lived positron emitter 89Zr for PET imaging...
  46. ncbi Radiation dosimetry of 89Zr-labeled chimeric monoclonal antibody U36 as used for immuno-PET in head and neck cancer patients
    Pontus K E Börjesson
    Department of Otolaryngology Head and Neck Surgery, VU University Medical Center, Amsterdam, The Netherlands
    J Nucl Med 50:1828-36. 2009
    ..In addition, the performance of immuno-PET for detecting lymph node metastases was evaluated, as described previously...
  47. ncbi Relevance of external beam dose-response relationships to kidney toxicity associated with radionuclide therapy
    JOSEPH O'DONOGHUE
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA
    Cancer Biother Radiopharm 19:378-87. 2004
    ..Animal studies have also clarified the dose-dependency of the time to expression of radiation nephropathy and have indicated that radiation nephropathy may be alleviated by pharmacological means...
  48. pmc Therapeutic radionuclides: biophysical and radiobiologic principles
    Amin I Kassis
    Department of Radiology, Harvard Medical School, Boston, MA 02115, USA
    Semin Nucl Med 38:358-66. 2008
    ..It also highlights what has been learned when these radionuclides and radiotargeting pharmaceuticals are used to treat cancers...
  49. ncbi [177Lu-DOTAOTyr3]octreotate: comparison with [111In-DTPAo]octreotide in patients
    D J Kwekkeboom
    Department of Nuclear Medicine, University Hospital Rotterdam, The Netherlands
    Eur J Nucl Med 28:1319-25. 2001
    ....
  50. ncbi Biodistribution and dosimetry of 177Lu-labeled [DOTA0,Tyr3]octreotate in male nude mice with human small cell lung cancer
    Anneli Schmitt
    Department of Radiation Physics, Lundberg Laboratory for Cancer Research, Goteborg University, Sahlgrenska University Hospital, Goteborg, Sweden
    Cancer Biother Radiopharm 18:593-9. 2003
    ..In this study the biodistribution of a somatostatin analogue, (177)Lu-[DOTA(0),Tyr(3)]octreotate, was investigated in an animal model, as a possible therapeutic radiopharmaceutical...
  51. ncbi [177Lu-DOTA(0),Tyr3] octreotate for somatostatin receptor-targeted radionuclide therapy
    M De Jong
    Department of Nuclear Medicine, University Hospital and Erasmus University Rotterdam, 3015 GD Rotterdam, The Netherlands
    Int J Cancer 92:628-33. 2001
    ..This candidate molecule shows great promise for radionuclide therapy in patients with sst(2)-expressing tumors...
  52. ncbi Bioremediation of radionuclides: emerging technologies
    Raj Kumar
    Division of Radiation Biology and Radiation Protection, Institute of Nuclear Medicine and Allied Sciences, New Delhi 100 054, India
    OMICS 11:295-304. 2007
    ..transcriptomics and proteomics. Studies combining functional transcriptomics and proteomics would create a system-wide approach studying the microbial metabolism in radionuclides detoxification...
  53. ncbi Organ doses from environmental exposures calculated using voxel phantoms of adults and children
    Nina Petoussi-Henss
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health GmbH, Research Unit Medical Radiation Physics and Diagnostics, Ingolstaedter Landstr 1, 85764 Neuherberg, Germany
    Phys Med Biol 57:5679-713. 2012
    ....
  54. ncbi Monte Carlo simulation of DNA damage induction by x-rays and selected radioisotopes
    Y Hsiao
    Department of Physics, Purdue University, West Lafayette, IN 47907 2036, USA
    Phys Med Biol 53:233-44. 2008
    To better assess the potential biological consequences of diagnostic x-rays and selected gamma-emitting radioisotopes used in brachytherapy, we used the PENELOPE Monte Carlo radiation transport code to estimate the spectrum of initial ..
  55. ncbi Dual-isotope PET using positron-gamma emitters
    A Andreyev
    Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada
    Phys Med Biol 56:4539-56. 2011
    ....
  56. ncbi Positron follow-up in liquid water: II. Spatial and energetic study for the most important radioisotopes used in PET
    C Champion
    Laboratoire de Physique Moléculaire et des Collisions, ICPMB FR 2843, Institut de Physique, Universite Paul Verlaine Metz, 1 Boulevard Arago, 57078 Metz Cedex 3, France
    Phys Med Biol 52:6605-25. 2007
    ..Quantitative information about positron penetrations, Positronium formation, annihilation event distributions, energy deposit patterns and dose profiles is then accessible and compared to published measurements and/or calculations...
  57. ncbi Measurement of airborne fission products in Chapel Hill, NC, USA from the Fukushima Dai-ichi reactor accident
    S Macmullin
    Department of Physics and Astronomy, University of North Carolina, Chapel Hill, NC 27599, USA
    J Environ Radioact 112:165-70. 2012
    ..42 ± 0.07 mBq/m(3) respectively. Additional activity from (131,132)I, (134,136,137)Cs and (132)Te were measured in the same air filters using a low-background HPGe detector at the Kimballton Underground Research Facility (KURF)...
  58. ncbi Microbial transformations of radionuclides: fundamental mechanisms and biogeochemical implications
    Jon R Lloyd
    School of Earth, Atmospheric and Environmental Sciences and The Williamson Research Centre for Molecular Environmental Sciences, The University of Manchester, Manchester M13 9PL, UK
    Met Ions Biol Syst 44:205-40. 2005
  59. pmc Radioimmunoimaging with longer-lived positron-emitting radionuclides: potentials and challenges
    Tapan K Nayak
    Radiation Oncology Branch, National Cancer Institute, National Institute of Health, Bethesda, MD 20892, USA
    Bioconjug Chem 20:825-41. 2009
    ....
  60. pmc Hormonal crises following receptor radionuclide therapy with the radiolabeled somatostatin analogue [177Lu-DOTA0,Tyr3]octreotate
    Bart de Keizer
    Department of Nuclear Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 35:749-55. 2008
    ..The aim of this study was to investigate the incidence of hormonal crises after therapy with the radiolabeled somatostatin analogue [(177)Lu-DOTA(0),Tyr(3)]octreotate ((177)Lu-octreotate)...
  61. ncbi Importance of receptor density in alpha radioimmunotherapy in B cell malignancies: an in-vitro study
    Katia Vandenbulcke
    Department of Radiopharmacy, Ghent University, Belgium
    Nucl Med Commun 25:1131-6. 2004
    ..The development of RIT with alpha emitters is attractive because of the high linear energy transfer (LET) and short path length, allowing higher tumour cell kill and lower toxicity to healthy tissues...
  62. ncbi Accumulation and soil-to-plant transfer of radionuclides in the Nile Delta coastal black sand habitats
    A K Hegazy
    Botany Department, Faculty of Science, Cairo University, Giza, Egypt
    Int J Phytoremediation 13:140-55. 2011
    ..The potentiality of S. glaucus as phytoremediator of radionuclides polluted soils is greater than R. pictus which in turn outweigh C. maritima...
  63. ncbi Prophylactic versus therapeutic alpha-blockers after permanent prostate brachytherapy
    Gregory S Merrick
    Schiffler Cancer Center, Wheeling Hospital, Wheeling, West Virginia 26003 6300, USA
    Urology 60:650-5. 2002
    ..Multiple clinical and treatment parameters were evaluated to identify the factors associated with acute urinary morbidity...
  64. ncbi Current concentration of artificial radionuclides and estimated radiation doses from 137Cs around the Chernobyl Nuclear Power Plant, the Semipalatinsk Nuclear Testing Site, and in Nagasaki
    Yasuyuki Taira
    Department of Radiation Epidemiology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Radiat Res 52:88-95. 2011
    ....
  65. ncbi In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage
    Katia Vandenbulcke
    Department of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Gent, Belgium
    Eur J Nucl Med Mol Imaging 30:1357-64. 2003
    ..Long-term toxicity on healthy B and T lymphocytes was systematically higher for the alpha emitter (RBE=5 to 2)...
  66. ncbi Kinetic modeling in positron emission tomography
    K C Schmidt
    Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892 4030, USA
    Q J Nucl Med 46:70-85. 2002
    ....
  67. ncbi Imaging reporter genes for cell tracking with PET and SPECT
    P D Acton
    Department of Radiology, Thomas Jefferson University, 796 G Main Building, 132 South 10th Street, Philadelphia, PA 19107, USA
    Q J Nucl Med Mol Imaging 49:349-60. 2005
    ..This review describes several reporter genes for PET and SPECT, and compares them against other techniques and imaging modalities...
  68. ncbi Radionuclide arthrogram with SPECT/CT for the evaluation of mechanical loosening of hip and knee prostheses
    Chong Ghee Chew
    Radiology SA, PO Box 1072, North Adelaide, SA, 5006, Australia
    Ann Nucl Med 24:735-43. 2010
    ..To evaluate the value of SPECT/CT in radionuclide arthrogram (RNA) for the assessment of mechanical loosening of hip and knee prostheses...
  69. pmc Direct imaging of radionuclide-produced electrons and positrons with an ultrathin phosphor
    Liying Chen
    Department of Radiology, University of Arizona, Tucson, Arizona 85724, USA
    J Nucl Med 49:1141-5. 2008
    ..This study was aimed at developing a sensitive high-resolution system capable of detecting electron-emitting isotopes in vivo...
  70. ncbi Bismuth-213 and actinium-225 -- generator performance and evolving therapeutic applications of two generator-derived alpha-emitting radioisotopes
    Alfred Morgenstern
    European Commission, Joint Research Centre, Institute for Transuranium Elements, 76125 Karlsruhe, Germany
    Curr Radiopharm 5:221-7. 2012
    ..Selected preclinical studies are highlighted and the current clinical experience with (225)Ac and (213)Bi is summarized...
  71. pmc Renal uptake of bismuth-213 and its contribution to kidney radiation dose following administration of actinium-225-labeled antibody
    J Schwartz
    Department of Medical Physics, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Phys Med Biol 56:721-33. 2011
    ..Methods to reduce renal accumulation of radioactive progeny appear to be necessary for the success of (225)Ac radioimmunotherapy...
  72. ncbi Modeling the long-term transport and accumulation of radionuclides in the landscape for derivation of dose conversion factors
    Rodolfo Moreno Avila
    Facilia AB, Bromma, Sweden
    Ambio 35:513-23. 2006
    ..The article also outlines an approach for estimating the exposure of man resulting from all possible reasonable uses of a potentially contaminated landscape, which was used for derivation of Landscape Dose Factors...
  73. ncbi Advances in SPECT imaging with respect to radionuclide therapy
    Y D'Asseler
    Department of Nuclear Medicine, MEDISIP, Medical Imaging and Signal Processing, Ghent University, Ghent, Belgium
    Q J Nucl Med Mol Imaging 53:343-7. 2009
    ..Novel detector technologies such as solid-state detectors may also prove to have significant advantages in this field...
  74. ncbi Transport and fate of radionuclides in aquatic environments--the use of ecosystem modelling for exposure assessments of nuclear facilities
    L Kumblad
    Department of Systems Ecology, Stockholm University, SE 106 91 Stockholm, Sweden
    J Environ Radioact 87:107-29. 2006
    ..Verification of the model suggests that this model produces analogous results to empirically derived data for more than 20 different radionuclides...
  75. ncbi Radioimmunotherapy with alpha-particle emitting radionuclides
    M R Zalutsky
    Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA
    Q J Nucl Med Mol Imaging 48:289-96. 2004
    ..The current status of preclinical and clinical research with antibodies labeled with 3 promising alpha-particle emitting radionuclides - (213)Bi, (225)Ac, and (211)At - also will be summarized...
  76. ncbi 177Lu-AMBA: Synthesis and characterization of a selective 177Lu-labeled GRP-R agonist for systemic radiotherapy of prostate cancer
    Laura E Lantry
    Ernst Felder Laboratories, Bracco Research USA Inc, Princeton, New Jersey 08540 6608, USA
    J Nucl Med 47:1144-52. 2006
    ..We describe a new radiolabeled bombesin (BBN) analog for imaging and systemic radiotherapy that has improved pharmacokinetics (PK) and better retention of radioactivity in the tumor...
  77. ncbi Comparative cellular catabolism and retention of astatine-, bismuth-, and lead-radiolabeled internalizing monoclonal antibody
    Z Yao
    Department of Nuclear Medicine, Warren G. Magnuson Clinical Center, National Institutes of Health, 10 Center Dr, Bethesda, MD 20892-1180, USA
    J Nucl Med 42:1538-44. 2001
    ..These catabolism differences may be important in the selection of alpha-radionuclides for radioimmunotherapy...
  78. ncbi Reliability of a new biokinetic model of zirconium in internal dosimetry: part I, parameter uncertainty analysis
    Wei Bo Li
    Research Unit Medical Radiation Physics and Diagnostics, Helmholtz Zentrum Munchen German Research Center for Environmental Health GmbH, D 85764 Neuherberg, Germany
    Health Phys 101:660-76. 2011
    ..The uncertainty information on the model parameters analyzed in this study was used in the second part of the paper regarding a sensitivity analysis of the Zr biokinetic models...
  79. ncbi An experimental comparison of the K- and L-Auger electron spectra generated in the decays of 140Nd and 111In
    E A Yakushev
    Joint Institute for Nuclear Research, Dubna RUS 141980, Russian Federation
    Appl Radiat Isot 62:451-6. 2005
    ....
  80. ncbi Radiopharmaceutical tracking of particles injected into tumors: a model to study clearance kinetics
    Wolfgang Luboldt
    Clinic and Policlinic of Nuclear Medicine, University Hospital Dresden, Fetscherstr 74, 01307 Dresden, Germany
    Curr Drug Deliv 6:255-60. 2009
    ..The purpose of this study was to establish a model for investigating the depot time of particles injected into tumors in relation to tumor vascularization and particle size...
  81. pmc Solid-tumor radionuclide therapy dosimetry: new paradigms in view of tumor microenvironment and angiogenesis
    Xuping Zhu
    Department of Radiology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    Med Phys 37:2974-84. 2010
    ....
  82. pmc Bifunctional coupling agents for radiolabeling of biomolecules and target-specific delivery of metallic radionuclides
    Shuang Liu
    School of Health Sciences, Purdue University, West Lafayette, USA
    Adv Drug Deliv Rev 60:1347-70. 2008
    ..This review will focus on the design of BFCs and their coordination chemistry with technetium, copper, gallium, indium, yttrium and lanthanide radiometals...
  83. ncbi Anti-tumor effect and increased survival after treatment with [177Lu-DOTA0,Tyr3]octreotate in a rat liver micrometastases model
    Wouter A P Breeman
    Department of Nuclear Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
    Int J Cancer 104:376-9. 2003
    ..177)Lu-DOTA-tate showed anti-tumoral effects in both cases and significant survival in the PRRT-treated rats. (177)Lu-DOTA-tate is a very promising new treatment modality for SSR-positive tumors, including disseminated disease...
  84. ncbi Human biokinetic data and a new compartmental model of zirconium--a tracer study with enriched stable isotopes
    Matthias B Greiter
    Helmholtz Zentrum Munchen, German Research Center for Environmental Health, Department of Medical Radiation Physics and Diagnostics, Ingolstädter Landstraße 1, 85764 Neuherberg, Germany
    Sci Total Environ 409:3701-10. 2011
    ..The proposed systemic model improves the existing ICRP model, yet is based on the same principles and fits well into the ICRP radiation protection approach...
  85. ncbi Detailed calculation of K- and L-Auger electron emission intensities following radioactive disintegration
    Marie Martine Bé
    LNE LNHB, Laboratoire National Henri Becquerel CEA Saclay, 91191 Gif sur Yvette Cedex, France
    Appl Radiat Isot 64:1435-9. 2006
    ..Good agreement was found between the values. Some of the results are given as examples...
  86. ncbi Monte Carlo-simulated Auger electron spectra for nuclides of radiobiological and medical interest - a validation with noble gas ionization data
    Ekkehard Pomplun
    Department of Safety and Radiation Protection, Forschungszentrum Julich, D 52425 Julich, Germany
    Int J Radiat Biol 88:108-14. 2012
    ..In particular, the need for an appropriate kinetic energy determination of the Auger electrons emitted from multiple-ionized atoms as well as the consideration of shake-off electrons would be investigated implicitly...
  87. ncbi Current status of therapy of solid tumors: brain tumor therapy
    Michael R Zalutsky
    Department of Radiology and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
    J Nucl Med 46:151S-6S. 2005
    ..The current status of these trials will be discussed with regard to efficacy, toxicity, and future directions...
  88. ncbi The addition of DTPA to [177Lu-DOTA0,Tyr3]octreotate prior to administration reduces rat skeleton uptake of radioactivity
    Wouter A P Breeman
    Department of Nuclear Medicine, Erasmus University Medical Center, Dr Molewaterplein 40, 3015 GD Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 30:312-5. 2003
    ..After labelling [DOTA(0),Tyr(3)]octreotate with (177)Lu the addition of DTPA prior to intravenous administration of [(177)Lu-DOTA(0),Tyr(3)]octreotate is strongly recommended...
  89. pmc Report on short-term side effects of treatments with 177Lu-octreotate in combination with capecitabine in seven patients with gastroenteropancreatic neuroendocrine tumours
    Martijn van Essen
    Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 35:743-8. 2008
    ..Adding capecitabine to (177)Lu-octreotate, as a radio-sensitiser, may enhance these anti-tumour effects. We now present the short-term toxicity profile of this novel combination...
  90. ncbi Territory contamination with the radionuclides representing the fuel component of Chernobyl fallout
    V A Kashparov
    Ukrainian Institute of Agricultural Radiology UIAR, Mashinobudivnykiv str 7, Chabany, Kyiv Svjatoshin Distr, Kyiv Reg 08162, Ukraine
    Sci Total Environ 317:105-19. 2003
    ..It amounts to 1.5+/-0.5% of these radionuclides in the reactor, which is 2 times lower than the previous estimates. Two-thirds of the radionuclides release in the FP was deposited on the territory of Ukraine...
  91. ncbi Movement of radionuclides in terrestrial ecosystems by physical processes
    Lynn R Anspaugh
    Department of Radiology, University of Utah, Salt Lake City 84108, USA
    Health Phys 82:669-79. 2002
    ..Chernobyl-related results on the movement of radionuclides into the soil column are presented, as is a revised model for this process based upon recent results from Ukraine...
  92. ncbi The potential for induction peptide receptor chemoradionuclide therapy to render inoperable pancreatic and duodenal neuroendocrine tumours resectable
    T W Barber
    Centre for Cancer Imaging, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002, Australia
    Eur J Surg Oncol 38:64-71. 2012
    ....
  93. ncbi Assessments for high dose radionuclide therapy treatment planning
    D R Fisher
    Pacific Northwest National Laboratory, 902 Battelle Boulevard, Richland, WA 99352, USA
    Radiat Prot Dosimetry 105:581-6. 2003
    ..Despite the general availability of software, internal dosimetry methods often seem to be inconsistent from one clinical centre to another...
  94. ncbi Differential bioaccumulation behaviour of Ag and Cd during the early development of the cuttlefish Sepia officinalis
    T Lacoue-Labarthe
    Littoral Environnement et Sociétés, UMR 6250, CNRS Université de La Rochelle, 2 rue Olympe de Gouges, F 17042 La Rochelle Cedex 01, France
    Aquat Toxicol 86:437-46. 2008
    ..Exposure to stable metals confirmed the saturation capacities of the eggshell for Cd and the Ag penetration properties...
  95. ncbi An analytic dosimetry study for the use of radionuclide-liposome conjugates in internal radiotherapy
    D Emfietzoglou
    Department of Medical Physics, University of Ioannina Medical School, Ioannina, Greece
    J Nucl Med 42:499-504. 2001
    ..Although much further work must be undertaken before any clinical application is considered, these results suggest that radionuclide targeting using liposomes is feasible and may have the advantage of reduced red marrow absorbed dose...
  96. ncbi Biodistribution, pharmacokinetics and microSPECT/CT imaging of 188Re-bMEDA-liposome in a C26 murine colon carcinoma solid tumor animal model
    Ya Jen Chang
    Institute of Nuclear Energy Research, Taoyuan, Taiwan, ROC
    Anticancer Res 27:2217-25. 2007
    ..7-fold higher than that of unencapsulated 188Re-BMEDA. These results suggested the potential benefit and advantage of 188Re-labeled nanoliposomes for imaging and treatment of malignant diseases...
  97. ncbi Synthesis of target-specific radiolabeled peptides for diagnostic imaging
    Jakub Fichna
    Department of Medicinal Chemistry, Medical University of Lodz, Lindleya 6, 90 131 Lodz, Poland
    Bioconjug Chem 14:3-17. 2003
  98. ncbi Labeling and biodistribution of different particle materials for radioembolization therapy with 188Re
    Gerd Wunderlich
    Department of Nuclear Medicine, University Hospital, Fetscherstr 74, D 01307 Dresden, Germany
    Appl Radiat Isot 62:745-50. 2005
    ..v. injection in Wistar rats revealed excellent in vivo stability with low uptake in the non-target tissues over 48 h for some polymeric particles and especially for biodegradable human serum albumin microspheres...
  99. ncbi Availability of rhenium-188 from the alumina-based tungsten-188/rhenium-188 generator for preparation of rhenium-188-labeled radiopharmaceuticals for cancer treatment
    F F Knapp
    Nuclear Medicine Program, Oak Ridge National Laboratory ORNL, TN, USA
    Anticancer Res 17:1783-95. 1997
    ....
  100. ncbi Tyr3-octreotide and Tyr3-octreotate radiolabeled with 177Lu or 90Y: peptide receptor radionuclide therapy results in vitro
    Astrid Capello
    Department of Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands
    Cancer Biother Radiopharm 18:761-8. 2003
    ..In conclusion, tyr3-octreotate labeled with 177Lu or 90Y is the most promising analog for PRRT...
  101. ncbi 99mTc/188Re-labelled lipid nanocapsules as promising radiotracers for imaging and therapy: formulation and biodistribution
    Sandrine Ballot
    Ecole Nationale Supérieure de Chimie de Rennes UMR CNRS 6052 Synthèses et Activations de Biomolécules, Institut de Chimie de Rennes, Avenue du General Leclerc, 35700, Rennes Beaulieu, France
    Eur J Nucl Med Mol Imaging 33:602-7. 2006
    ..To assess their potential for clinical use, we labelled nanocapsules with (99m)Tc and (188)Re and analysed some kinetic biodistribution parameters after intravenous injection in rats...

Research Grants63

  1. RADIATION-INDUCED THYROID CANCER
    Heinz Ulrich G Weier; Fiscal Year: 2011
    ..In 1986, an accident at the nuclear power plant in Chernobyl, USSR, led to the release of high levels of radioisotopes. Ten years later, the incidence of childhood papillary thyroid cancer (chPTC) near Chernobyl had risen by 2 ..
  2. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    Positron emission tomography (PET) radioisotopes, such as carbon-11 (11C) and fluorine-18 (18F), will be incorporated into current antibiotics, such as the tuberculosis drugs isoniazid and rifampicin, in order to directly identify the ..
  3. Fluorescein for Sentinel Lymph Node Detection
    James M McGreevy; Fiscal Year: 2012
    ..improve surgical outcomes worldwide, including rural and community hospitals where the access to short-lived radioisotopes for intraoperative use may not exist...
  4. CD45 Pretargeted Radioimmunotherapy for AML
    Oliver W Press; Fiscal Year: 2013
    ..3 we will compare the therapeutic efficacy of pretargeted ??emitting radionuclides with pretargeted ? emitting radioisotopes (213Bi 211At, 225Ac) in the 4 mouse models described in Aim 2...
  5. Transcriptional role of TLE3 in brown adipose tissue development and metabolism
    Claudio J Villanueva; Fiscal Year: 2013
    ..at UCLA and attending conferences, I will take courses that will enhance technical training in the use of radioisotopes for the study of metabolic pathways, protein purification and characterization, and next generation sequencing ..
  6. Post-Irradiation Intervention to Mitigate and Treat Non Hematological Radiation
    JOHN MOULDER; Fiscal Year: 2009
    ..But for partial-body exposure or for internally-deposited radioisotopes (where radiation doses may be high but some bone marrow may be spared), or if the bone marrow damage can be ..
  7. A rapid, sensitive assay for quantitation of human prorenin in biological samples
    DUANE ELLINGTON DAY; Fiscal Year: 2010
    ..Currently, assays to detect prorenin levels are plagued by extremely lengthy procedures, use of radioisotopes, and inaccuracy related to the variable activation state of prorenin...
  8. University of New Mexico Cancer Center Support
    Cheryl L Willman; Fiscal Year: 2013
    ..and disparity;the integration of regional scientific strengths in engineering, biotechnology, nanotechnology, radioisotopes, drug discovery, imaging, and high performance computing into its Research Programs and Shared Resources;and ..
  9. Quantitative Measurement of Isotope Ratios by TOF-SIMS MS
    Marvin L Vestal; Fiscal Year: 2012
    ..Accelerator mass spectrometry has demonstrated the utility of long-lived radioisotopes as biological tracers, but applications have been limited by the relatively hig cost and inaccessibility of ..
  10. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    ..Due to the short half-lives of these radioisotopes, the synthesis and purification of 18F- and especially 11C-tracers must be performed with extreme rapidity if ..
  11. A Mini-Cyclotron Facility to Support Cancer Research at the BIDMC/HMS
    John V Frangioni; Fiscal Year: 2010
    ..Fortunately, a new trend in the production of PET radioisotopes is to utilize a turnkey "mini-cyclotron," in conjunction with an integrated microfluidics chemistry system, to ..
  12. Biomimetic Actinide Decorporation: Characterization and Preclinical Development
    David K Shuh; Fiscal Year: 2010
    ..terrorism have become more plausible, and the risk of environmental contamination and human exposure to radioisotopes consequently increased...
  13. PET Enabled Microspheres for Radioembolization of Liver Tumors
    YONGREN BENJAMIN PENG; Fiscal Year: 2012
    ..microspheres (Therasphere(R) or SIR-Spheres(R)) for optimal dose and treatment planning and perfect surrogates to the next generation Y-90 microspheres, which will include companion PET radioisotopes for quantitative imaging.
  14. Targeted Molecular Nano-Irradiation Against a Malignant Glioma Biomarker
    Akiva Mintz; Fiscal Year: 2010
    ..In contrast, Auger emitting radioisotopes only have nanometer reach and therefore can only kill cells if they can access the nucleus and intimately ..
  15. Multi-Layered Valency: A Novel Design of Peptidic Imaging Agents for ??v??6
    Xiankai Sun; Fiscal Year: 2013
    ..Synthetic peptides have attracted attention as targeting molecules to deliver radioisotopes to in vivo targets for imaging...
  16. Development of Novel Immunoconjugates for Application in Cancer Therapeutics
    DOUGLAS DEAN YOUNG; Fiscal Year: 2010
    ..These antibodies can be coupled to a variety of therapeutic agents such as toxins, radioisotopes, or other biomacromolecules...
  17. Radioactive Stents for Brachytherapy of Esophageal Cancers
    YONGREN BENJAMIN PENG; Fiscal Year: 2013
    ..The Phase I research focuses on the therapeutic energy of radioisotopes and the integration of radioisotope sources with popular stents...
  18. Multifunctional Photosensitizers for Image-guided PDT of Brain Tumors
    Ravindra K Pandey; Fiscal Year: 2012
    ..addition, our approach can be extended to multi- modality interventions: The conjugate can deliver therapeutic radioisotopes, and PDT can super-additively potentiate radiotherapy...
  19. Pediatric template of brain perfusion
    DANNY JIONG JIONG WANG; Fiscal Year: 2013
    ..safety concerns and technical difficulties associated with existing methods to measure perfusion that rely on radioisotopes and contrast agents...
  20. F-18 Labeled Peptides for Pretargeted PET Imaging of Pancreatic Cancer
    WILLIAM JOHN MCBRIDE; Fiscal Year: 2010
    ..Using this system, radiolabeled peptides can be prepared with a variety of radioisotopes for use in imaging and therapy...
  21. The roles of TfRs and HSPA5 in Pu uptake
    Gayle E Woloschak; Fiscal Year: 2013
    ..Many Pu radioisotopes have very long half-lives and their extended storage leads to risks of eventual contamination that can affect ..
  22. Self-contained X-ray Blood Irradiator
    BABU CHALAMALA; Fiscal Year: 2010
    ..These two isotopes constitute the most dangerous and most prevalent of all radioisotopes in the NRC inventory...
  23. INORGANIC ION EXCHANGERS FOR 213BI GENERATORS
    Paul Sylvester; Fiscal Year: 1999
    ..Ion exchange kinetics will also be evaluated and suitable eluants identified. Phase II will use radioisotopes at Argonne National Laboratory to optimize the 213Bi/225Ac separation, further materials will be synthesized ..
  24. PERINATAL METABOLIC STRESS AND BRAIN GLUCOSE TRANSPORT
    SUSAN VANNUCCI; Fiscal Year: 1999
    ..transport capacity) and cerebral glucose utilization will be determined in vivo in same aged animal with radioisotopes; 2) the determination of the temporal and regional patterns of the levels of GLUT1, 3 & 5 following ..
  25. BILIARY ATRESIA IN THE INV MOUSE
    David Perlmutter; Fiscal Year: 2000
    ..for staining biliary epithelial cells in serial sections and methods for analyzing biliary excretion of radioisotopes were developed...
  26. ANTIBODY-TARGETED POLYMERIC SYSTEMS FOR TUMOR IMAGING
    Vladimir Torchilin; Fiscal Year: 2006
    ..To attach metals serving as radioisotopes and paramagnetic moieties to an antibody, chelating groups are introduced into a protein molecule...
  27. DEVELOPMENT OF RADIATION SYNOVECTOMY IN ARTHRITIS
    Clement Sledge; Fiscal Year: 1992
    ..ablation of inflamed synovium following intra-articular administration of short-range, beta-emitting radioisotopes. The isotope is complexed to a particulate carrier in order to delay and decrease leakage rom the joint, ..
  28. ACS-TR19 CYCLOTRON
    Robert C McKinstry; Fiscal Year: 2012
    ..By significantly enhancing our reliability to produce radioisotopes, PET research can continue without concern of complications due to frequent and severe maintenance issues ..
  29. TARGETED METAL CHELATORS FOR DIAGNOSTIC IMAGING
    Michael Welch; Fiscal Year: 2001
    Metal radionuclides are widely used in diagnostic imaging. Radioisotopes of gallium, indium, technetium and copper are used in nuclear medicine studies while gadolinium chelates act as paramagnetic contrast agents in conjunction with ..
  30. PET/SPECT/CT Camera for Small Animal Imaging at UMMS
    Donald Hnatowich; Fiscal Year: 2007
    ..higher intrinsic resolution, 99mTc, the most useful radionuclide in diagnostic nuclear medicine, and iodine radioisotopes (125I and 123I) critical for emerging in vivo proteomics research...
  31. Contrast-Enhanced Ultrasound Detection of Secondary Lymph Nodes
    Barry B Goldberg; Fiscal Year: 2010
    ..Two methods are currently used to identify SLNs;peritumoral injection of radioisotopes followed by either scintigraphy or gamma probe evaluation and injection of dye with detection of dye-stained ..
  32. BIOLUMINESCENT PROTEINS AS LABELS IN DIAGNOSTIC ASSAYS
    MILTON CORMIER; Fiscal Year: 1992
    ..Typical biochemical detection methods, such as radioimmunoassays and enzyme-linked immunosorbant assays, use radioisotopes and enzymes, respectively, as labels...
  33. MECHANISMS BY WHICH CHLOROPHENOLS ACT AS CYTOTOXINS
    E Bittar; Fiscal Year: 1991
    ..As for the technical aspects of the proposed work, multidisciplinary techniques, involving radioisotopes, photoproteins, microelectrodes, assays, gel electrophoresis and so on, are available in this laboratory...
  34. Processing Ac-227 sources for lead-212 and radium-223 required by cancer research
    CHUCK SODERQUIST; Fiscal Year: 2007
    ..This Phase I grant application and a follow-on Phase II application proposes to increase the amount of radioisotopes required to support later stage research and anticipated approved drug products in therapies that are showing ..
  35. Separation of Sr-90 and Ca2+ in Environmental Samples
    TERESIA MOLLER; Fiscal Year: 2004
    ..This need has been revealed by the constant need faced by DOE to treat groundwater contaminated by radioisotopes in efforts to prevent further contamination of ddnking water and eventually the food chain to humans, and the ..
  36. Atoms for Peace and Health: Radioisotopes in Postwar Biomedicine
    ANGELA CREAGER; Fiscal Year: 2009
    ..Even as the atomic bomb became the currency of the Cold War, radioisotopes represented the government's efforts to harness the power of the atom for peace-advancing medicine, ..
  37. Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)
    Kenneth W Turteltaub; Fiscal Year: 2011
    ..AMS) was established in 1999 to enable biomedical researchers to accurately quantify very low levels of radioisotopes while exploring fundamental issues in biology...
  38. N-PINHOLE GAMMA-EMISSION COMPUTED TOMOGRAPHY
    KENNETH KORAL; Fiscal Year: 1980
    ..The above tomographies assume radioisotopes which emit a single gamma of interest per decay...
  39. Production of Y-90 Microspheres for Radiation Therapy
    YONGREN PENG; Fiscal Year: 2002
    ..process will be optimized with regard to minimized personnel radiation exposure, maximized use of source radioisotopes, much shortened overall process time to preserve radioactivity, and above all, much reduced cost...
  40. FLOW/SURFACE EFFECTS ON PLATELET GPIIB-IIIA
    Steven Slack; Fiscal Year: 1992
    ..Platelet adhesion to protein-coated materials will be measured with radioisotopes and an Enzyme- Linked ImmunoSorbent Assay (ELISA) technique; GP IIb-IIIa binding will be quantified with ELISA ..
  41. Novel glutamate conjugates for radiotargeting PSMA
    John Babich; Fiscal Year: 2004
    ..chemistry knowledge base of inhibitors of PSMA, so as to allow subsequent labeling with 99mTc or 186/1888Re radioisotopes for imaging or therapeutic applications, respectively...
  42. REVERSIBLE GELS FOR DELIVERY OF MEDICAL RADIOISOTOPES
    Anna Gutowska; Fiscal Year: 2000
    ..abstract_text> ..
  43. TIMED-BIORESORBABLE RADIOSEEDS FOR PROSTATE CANCER
    YONGREN PENG; Fiscal Year: 2001
    b>Radioisotopes used for prostate cancer treatment are predominately photon/gamma-emitters (I-125, Pd-103, Ir-192). Both temporary and permanent gamma-emitting radioseeds have gained acceptance for interstitial implantation in the prostate...
  44. Radioactive Nanoparticle Immunoconjugates for the Treatment of Solid Tumors
    Gregory Adams; Fiscal Year: 2009
    ..known as Radioimmunotherapy (RAIT) entails employing anti-tumor antibodies to deliver cytotoxic agents such as radioisotopes. While RAIT has been effective in the treatment of hematological malignancies, its utility against solid ..
  45. TIMED BIORESORBABLE Y 90 MICROSPHERES FOR RADIOTHERAPY
    YONGREN PENG; Fiscal Year: 2000
    Timed-bioresorbable microspheres are being investigated as a vehicle for delivery of radioisotopes, particularly, Y-90 for localized radiotherapy...
  46. HYPOTHERMIC CARDIAC ARREST AND PERINATAL BRAIN DAMAGE
    ROBERT VANNUCCI; Fiscal Year: 1992
    ..recovery from hypothermic circulatory arrest, using iodo-(14C)-anti-pyrine and 2-deoxy-(14C)-glucose as the radioisotopes. Regional oxidative and energy metabolism will be determined also during the following hypothermic circulatory ..
  47. STABLE ISOTOPE LABELED PROTEINS AND DRUG DISPOSITION
    Fred Abramson; Fiscal Year: 2002
    ..Yet, suitable methods for studying protein drug disposition do not exist. Radioisotopes, bioassays, and immunoassays all present problems...
  48. Targeting alpha particle-emitting radionuclides to the nuclei of cancer cells
    Thomas Quinn; Fiscal Year: 2007
    ..of radiolabeled alpha-melanocyte stimulating hormone (a-MSH) peptide analogs that target a-particle emitting radioisotopes to the nuclei of melanoma cells...
  49. MENTORED PATIENT ORIENTED RESEARCH CAREER DEVELOPMENT AW
    John Sampson; Fiscal Year: 2004
    ..through the use of human chimeric MAbs with increased biostability and the use of high linear energy transfer radioisotopes, such as (211)At, with greater relative biological effectiveness...
  50. LUMINESCENCE DETECTION REAGENTS FOR FOOD PATHOGENS
    David Smith; Fiscal Year: 1992
    ..is more rapid and 3 to 6 orders of magnitude more sensitive than existing techniques and that does not utilize radioisotopes. This new technology exploits the remarkable sensitivity of the recombinant, bioluminescent protein, aequorin, ..
  51. ABI 3700 DNA ANALYZER
    David Ledbetter; Fiscal Year: 2001
    ..Early human studies of mineral metabolism relied on the use of mineral radioisotopes. These studies are no longer ethical in all population groups and the difficulties and costs associated with ..
  52. RADIOPHARMACEUTICALS TARGETED TO TUMOR FOLATE RECEPTORS
    Mark Green; Fiscal Year: 2003
    ..The specific aims of the project involve the synthesis of folate-conjugates designed for labeling with radioisotopes of In, Cu and Y, followed by characterization of their ability to selectively target tumor cells in vitro and ..
  53. A Multi-Function Surgical Probe
    TUMAY TUMER; Fiscal Year: 2004
    ..Probes must detect a range of radiopharmaceuticals that utilize different radioisotopes. The proposed intra-operative surgical probe with enhanced performance aims to improve localization of ..
  54. Cancer Therapy with Targeted Radioactive Nanoparticles
    Brian Smith; Fiscal Year: 2006
    ..the Candidate proposes to increase the efficacy of RAIT in the setting of malignant solid tumors by packaging radioisotopes in the form of nanoparticles (NPs). This project is a unique collaboration between Candidate Dr...
  55. Pediatric template of brain perfusion
    Jiongjiong Wang; Fiscal Year: 2006
    ..safety concerns and technical difficulties associated with existing methods to measure perfusion that rely on radioisotopes and contrast agents...
  56. PHOTOPRODUCTION OF MEDICAL RADIOISOTOPES
    Edward Knapp; Fiscal Year: 1999
    We propose to investigate producing medical radioisotopes with photons generated by an electron beam...
  57. X-SPECTTM for Functional & Anatomic Imaging In Vivo
    Sissy Jhiang; Fiscal Year: 2006
    ..The X-SPECT(tm) imaging system is capable of imaging large number of single photon emitting radioisotopes that are readily available, such as 1-125 (30 keV), TI-201 (75 keV), 1-123 (159 keV), ln-111 (171, 250 keV) ..
  58. Intracerebral Infusion of Radiolabeled Specific Antibody
    John Sampson; Fiscal Year: 2006
    ..through the use of human chimeric MAbs with increased biostability and the use of high linear energy transfer radioisotopes, such as 211-At, with greater relative biological effectiveness...
  59. AN INTRAVASCULAR X-RAY SOURCE FOR RESTENOSIS TREATMENT
    RUTH SHEFER; Fiscal Year: 2002
    ..Ongoing clinical trials of intravascular brachytherapy for restenosis use gamma or beta-emitting radioisotopes delivered to the angioplasty site via a guide catheter and withdrawn when sufficient dose has been delivered ..
  60. Resource for the Development of Biomedical Accelerator Mass Spectrometry (AMS)
    Kenneth W Turteltaub; Fiscal Year: 2013
    ..AMS) was established in 1999 to enable biomedical researchers to accurately quantify very low levels of radioisotopes while exploring fundamental issues in biology...
  61. Myocardial perfusion imaging & dedicated cardiac camera
    Gina Caravaglia; Fiscal Year: 2005
    ..At present, perfusion studies are preformed on conventional large field of view gamma cameras. Multiple radioisotopes are utilized with a multitude of imagining protocols...
  62. Novel agents for mitigation of radiation-induced pulmonary injury
    KATHRYN HELD; Fiscal Year: 2009
    ..individuals will receive substantial radiation exposure to the lungs either from external radiation or inhaled radioisotopes, and the pulmonary injury could be lethal or life threatening...
  63. Hemodynamic neuroimaging of pediatric stroke
    Jiongjiong Wang; Fiscal Year: 2006
    ..CBF) measurements in adults cannot be easily applied on children due to safety concerns related to the use of radioisotopes and the logistical difficulties in rapidly injecting contrast agents in pediatric patients...