Genomes and Genes
Summary: Stable phosphorus atoms that have the same atomic number as the element phosphorus, but differ in atomic weight. P-31 is a stable phosphorus isotope.
Publications189 found, 100 shown here
- Skeletal muscle energetics with PNMR: personal views and historic perspectivesBritton Chance
Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
NMR Biomed 19:904-26. 2006..Some of the research has been introduced in exercise physiology. Future directions of NMR on bioenergetics, as a part of system biological approaches, are indicated...
- Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxiaChristian Wolf
Department of Radiology I, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
Mol Imaging Biol 10:24-9. 2008..The purpose of this study was to investigate cardiac function and high-energy phosphate metabolism in FRDA patients with late disease onset...
- Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurementsIan R Lanza
Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
J Magn Reson Imaging 34:1143-50. 2011..To cross-validate skeletal muscle oxidative capacity measured by (31)P-MR spectroscopy with in vitro measurements of oxidative capacity in mitochondria isolated from muscle biopsies of the same muscle group in 18 healthy adults...
- Assessment of (31)P relaxation times in the human calf muscle: a comparison between 3 T and 7 T in vivoW Bogner
Department of Radiology, Medical University Vienna, Vienna, Austria
Magn Reson Med 62:574-82. 2009..2 Hz to 11.2 +/- 1.9 Hz or +72%. At 7 T (31)P-MRS in the human calf muscle offers more than twice as much SNR per unit time in reduced measurement time compared to 3 T. This will facilitate in vivo (31)P-MRS of the human muscle at 7 T...
- Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux ratesNicole M A van den Broek
Biomedical NMR, Dept of Biomedical Engineering, Eindhoven University of Technology, N laag b1 08, PO Box 513, 5600 MB Eindhoven, The Netherlands
Am J Physiol Cell Physiol 293:C228-37. 2007..Our study implies that simply correcting tau(PCr) for end-exercise pH is not adequate, in particular when comparing patients and control subjects, because certain disorders are characterized by altered proton efflux from muscle fibers...
- 31P saturation transfer spectroscopy predicts differential intracellular macromolecular association of ATP and ADP in skeletal muscleChristine Nabuurs
Department of Radiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
J Biol Chem 285:39588-96. 2010..We present a model, matching the experimental result, for ADP ↔ ATP exchange, in which ADP is only transiently present in the cytosol...
- Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopyDouglas E Befroy
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
Methods Enzymol 457:373-93. 2009..We will also examine applications of the techniques to investigate how these parameters of muscle mitochondrial metabolism are modulated in insulin resistant and endurance trained individuals...
- 31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathyTina Dysgaard Jeppesen
Neuromuscular Research Unit, Section 7611, National University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
J Neurol 254:29-37. 2007..Thus, (31)P-MRS should not be a routine test for MM, but may be an important research tool...
- Soil and litter phosphorus-31 nuclear magnetic resonance spectroscopy: extractants, metals, and phosphorus relaxation timesB J Cade-Menun
Dep of Environmental Sciences, Policy and Management, Univ of California at Berkeley, USA
J Environ Qual 31:457-65. 2002....
- Dynamic MRS and MRI of skeletal muscle function and biomechanicsJeanine J Prompers
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
NMR Biomed 19:927-53. 2006....
- Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunctionH M De Feyter
Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
Eur J Endocrinol 158:643-53. 2008....
- Comparison of measuring energy metabolism by different (31) P-magnetic resonance spectroscopy techniques in resting, ischemic, and exercising muscleAlbrecht I Schmid
MR Center of Excellence, Medical University of Vienna, Vienna, Austria
Magn Reson Med 67:898-905. 2012..Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc...
- 31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptakeD E Larson-Meyer
Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, Birmingham, AL 35205, USA
NMR Biomed 13:14-27. 2000..41-0.72; p < 0.05). These results suggest that measurements of TC(PCr), TC(ADP) and OxPhos yield reproducible results that correlate with whole-body VO(2max) and that vary in force-level sensitivity...
- Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjectsV B Schrauwen-Hinderling
Department of Radiology, University Hospital Maastricht, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
Diabetologia 50:113-20. 2007..As obesity is an independent determinant of IMCL content, we examined mitochondrial function and IMCL content in overweight type 2 diabetes patients and BMI-matched normoglycaemic controls...
- Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetesMichaela Scheuermann-Freestone
Department of Biochemistry, University of Oxford, Oxford OX1 3PT, England
Circulation 107:3040-6. 2003..It is well known that patients with type 2 diabetes have increased risk of cardiovascular disease, but it is not known whether they have underlying abnormalities in cardiac or skeletal muscle high-energy phosphate metabolism...
- Phosphocreatine recovery kinetics following low- and high-intensity exercise in human triceps surae and rat posterior hindlimb musclesSean C Forbes
Dept of Physiology 2201 BPS Bldg, Michigan State Univ, East Lansing, MI 48824, USA
Am J Physiol Regul Integr Comp Physiol 296:R161-70. 2009..In addition, the observation of a fast component following high-intensity exercise is consistent with the notion that glycolytic ATP production contributes to PCr resynthesis during the initial stage of recovery...
- Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedbackFan Wu
Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
Am J Physiol Cell Physiol 292:C115-24. 2007....
- Tightly coupled brain activity and cerebral ATP metabolic rateFei Du
Department of Radiology, Center for Magnetic Resonance Research and Department of Biomedical Engineering, University of Minnesota Medical School, Minneapolis, MN 55455, USA
Proc Natl Acad Sci U S A 105:6409-14. 2008....
- Defective brain and muscle energy metabolism shown by in vivo 31P magnetic resonance spectroscopy in nonaffected carriers of 11778 mtDNA mutationB Barbiroli
Cattedra di Biochimica Clinica, , Italy
Neurology 45:1364-9. 1995..All subjects without mutation had normal brain and muscle MRS. 31P-MRS disclosed defective bioenergetics in the brain or muscle or both of all asymptomatic carriers studied from our pedigree...
- Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experimentA I Schmid
Karl Landsteiner Institute of Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria
NMR Biomed 21:437-43. 2008..In conclusion, 31P MRS at 3 T provides sufficient sensitivity to detect magnetization transfer effects and can therefore be used to assess ATP synthesis in human liver...
- 31P MR spectroscopy and in vitro markers of oxidative capacity in type 2 diabetes patientsS F E Praet
Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200, MD, Maastricht, The Netherlands
MAGMA 19:321-31. 2006..However, microvascular co-morbidity in long-standing T2D can interfere with the (31)P MRS methodology...
- Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burnA Aria Tzika
Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Mol Med 21:201-8. 2008..That PGC-1beta is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1beta...
- Reproducibility assessment of metabolic variables characterizing muscle energetics in vivo: A 31P-MRS studyGwenael Layec
Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine de Marseille, Marseille, France
Magn Reson Med 62:840-54. 2009..In addition, the corresponding metabolic measurements can reliably be used for longitudinal studies performed even over a long period of time...
- Three-dimensional high-resolution magnetic resonance spectroscopic imaging for absolute quantification of 31P metabolites in human liverM Chmelik
Karl Landsteiner Institute for Endocrinology and Metabolism, Vienna, Austria
Magn Reson Med 60:796-802. 2008..This method allows for examination of regional deviations of energy metabolism in human liver diseases...
- BII nucleotides in the B and C forms of natural-sequence polymeric DNA: A new model for the C form of DNAL van Dam
Department of Physical Chemistry Arrhenius Laboratory, Stockholm University, Stockholm, S 106 91, Sweden
J Mol Biol 304:541-61. 2000..This work shows that the B to C transition in fibers corresponds to BI to BII conformational changes of the individual nucleotides...
- Butyrate impairs energy metabolism in isolated perfused liver of fed ratsM C Beauvieux
Service de Nutrition et Diabétologie, Hopital Haut Leveque, F 33600 Pessac France
J Nutr 131:1986-92. 2001..In conclusion, the difference in the hepatic oxidation pathways of two products of intestinal fermentation (acetate and butyrate) explains their different actions on energy metabolism...
- MR spectroscopy in heart failureCameron Holloway
Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
Front Biosci (Schol Ed) 3:331-40. 2011..MRS signals from 31P, 1H, 23Na and 13C, including novel hyperpolarization techniques, have provided considerable insight into the understanding of energy metabolism in the healthy and diseased heart...
- Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopyEe Lin Lim
Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
NMR Biomed 23:952-7. 2010..03 vs baseline). The in vivo time course of insulin stimulation of skeletal muscle ATP turnover rate is not consistent with a rate limiting effect upon the initiation of insulin-stimulated glycogen synthesis...
- Measurement of intracellular (compartmental) pH by 31P NMR in Aspergillus nigerS J Hesse
Department of Molecular Physics, Wageningen Agricultural University, The Netherlands
J Biotechnol 77:5-15. 2000..6 and 1.4, respectively)...
- Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brainFei Du
Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
Magn Reson Med 57:103-14. 2007..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases...
- P-31 magnetic resonance spectroscopy. A tool for diagnostic purposes and pathophysiological insights in muscle diseasesJ P Mattei
Centre de Resonance Magnetique Biologique et Medicale, CRMBM, UMR CNRS 6612, Faculte de Medecine, Marseille, France
Reumatismo 56:9-14. 2004..Finally, the contribution of 31P MRS to our understanding of the physiopathology of several other diseases is highlighted...
- Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivityRuth C R Meex
Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
Diabetes 59:572-9. 2010..We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes...
- Abnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivoGraham J Kemp
Department of Musculoskeletal Science, University of Liverpool, Liverpool L69 3GA, UK
Nephrol Dial Transplant 19:1520-7. 2004....
- Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitroZ M Bhujwalla
Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
Magn Reson Med 41:897-903. 1999..These results suggest that nm23 genes may affect suppression of metastasis through phospholipid-mediated signaling and cellular pH regulation...
- Noninvasive measurements of cardiac high-energy phosphate metabolites in dilated cardiomyopathy by using 31P spectroscopic chemical shift imagingA Hansch
Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
Eur Radiol 15:319-23. 2005..In addition to reduced PCr/ATP ratios observed in patients suffering from DCM, significantly-increased PDE/ATP ratios were found in patients with severe DCM...
- [Non-invasive investigation of muscle function using 31P magnetic resonance spectroscopy and 1H MR imaging]D Bendahan
Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS No 6612, Faculte de Medecine de Marseille
Rev Neurol (Paris) 162:467-84. 2006..As a research tool, it will keep bringing new information on the physiopathology of muscle diseases in animal models and in humans and should play a role in the metabolic characterization of gene and cell therapy...
- Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic studyB N Gangadhar
Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, 560 029 Bangalore, India
Am J Psychiatry 161:1304-6. 2004..This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia...
- Variations due to analysis technique in intracellular pH measurements in simulated and in vivo 31P MR spectra of the human brainGavin Hamilton
Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom
J Magn Reson Imaging 23:459-64. 2006..Three different methods were used to measure the chemical shift of inorganic phosphate (Pi) relative to phosphocreatine (PCr)...
- 31P MRS of heart grafts provides metabolic markers of early dysfunctionThierry Caus
Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Fac Med, 27 Bd Jean Moulin, 13005 Marseille, France
Eur J Cardiothorac Surg 28:576-80. 2005..We tested whether selected metabolic markers, including high-energy phosphate concentrations measured ex vivo in pre-transplant heart grafts by (31)P magnetic resonance spectroscopy (MRS) are related with early post-transplant outcome...
- Non-invasive diagnostic of cardiac allograft vasculopathy by 31P magnetic resonance chemical shift imagingThierry Caus
Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Faculte de Medecine, 27 Bd Jean Moulin, 13005 Marseille, France
Eur J Cardiothorac Surg 29:45-9. 2006..In this study, we assessed whether 31P magnetic resonance chemical shift imaging can diagnose CAV by studying variations in cardiac high-energy phosphates in a population of adult heart transplant recipients...
- New experimental setup for studying strictly noninvasively skeletal muscle function in rat using 1H-magnetic resonance (MR) imaging and 31P-MR spectroscopyBenoit Giannesini
Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Faculte de Medecine de Marseille, Marseille, France
Magn Reson Med 54:1058-64. 2005..This opens up new perspectives in various research areas including pharmaceutical research...
- Direct action of T3 on phosphorylation potential in the sheep heart in vivoMichael A Portman
Division of Cardiology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Wahington 98105, USA
Am J Physiol Heart Circ Physiol 288:H2484-90. 2005..These T3-induced effects are not due to changes in ADP/ATP exchange efficiency through action at the adenine nucleotide translocator but may be due to T3 mediation of substrate utilization, confirmed in other models...
- Detection of myocardial infarctions by acquisition-weighted 31P-MR spectroscopy in humansMeinrad Beer
Institut für Röntgendiagnostik, Universitat Wurzburg, Wurzburg, Germany
J Magn Reson Imaging 20:798-802. 2004..To determine whether the recently applied technique of acquisition-weighted 31P-MR spectroscopy (AW-MRS) allows for the detection of depressed energy metabolism in patients with inferior wall myocardial infarctions...
- A technique for the measurement of renal ATP in a large animal model of septic shockC May
Howard Florey Institute, University of Melbourne, Parkville, Australia
Int J Artif Organs 28:16-21. 2005..The mechanisms responsible for acute renal failure in sepsis are not understood. Measurement of tissue ATP might help to understand this process but, in the large animal, it is hampered by major technical difficulties...
- Brain energetics and tolerance to anoxia in deep hypothermiaRadoslav K Andjus
University of Belgrade, Yugoslavia
Ann N Y Acad Sci 1048:10-35. 2005..The results contribute to the understanding of the role of brain energetics in tolerance to oxygen deprivation...
- The influence of tissue blood flow volume on energy metabolism in masseter musclesKazuki Okada
Dept of Gnathofunctional Medicine, Graduate School of Dental Medicine, Hokkaido University, West 7 North 13, Kita ku, Sapporo 060 8586, Japan
Cranio 23:166-73. 2005....
- Metabolism of perfused pig intercostal muscles evaluated by 31P-magnetic resonance spectroscopyBrian Lindegaard Pedersen
Nuclear Magnetic Resonance Centre, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark
Exp Physiol 91:755-63. 2006..The preparation can also be applied to human intercostal muscles, as demonstrated in one preliminary experiment. The results demonstrate a stable and functional in vitro preparation of intact perfused intercostal muscles in the pig...
- Heart slice NMRTadayuki Uetani
Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
Am J Physiol Heart Circ Physiol 292:H1181-6. 2007..Heart slice preparation could also be used to evaluate the potency of cardiac drugs, regardless of their possible effects on coronary microcirculation...
- In vivo modular control analysis of energy metabolism in contracting skeletal muscleLaurent M Arsac
Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS Centre National de la Recherche Scientifique, Universite Bordeaux 2, Bordeaux, France
Biochem J 414:391-7. 2008....
- Impaired resting muscle energetics studied by (31)P-NMR in diet-induced obese ratsEmilie Chanseaume
INRA, UMR1019, Clermont Ferrand, France
Obesity (Silver Spring) 16:572-7. 2008..For that purpose, we used in vivo (31)P-nuclear magnetic resonance ((31)P-NMR) in male sedentary Wistar rats fed with obesogenic diets known to induce alterations in muscle mitochondrial activity...
- Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementationJeffrey J Brault
Dept of Physiology, Michigan State University, East Lansing, MI 48824, USA
Int J Sport Nutr Exerc Metab 17:624-34. 2007..TCr (14.9% +/- 4.1%) at any time point. The results indicate that creatine supplementation does not alter the PCr:TCr ratio, and hence the cytoplasmic Gibbs free energy of ATP hydrolysis, in human skeletal muscle at rest...
- Evidence of brain mitochondrial activities after oxygen inhalation by 31P magnetic resonance spectroscopy at 3TRen Hua Wu
Department of Medical Imaging, Shantou University Medical College, China
Conf Proc IEEE Eng Med Biol Soc 2007:2899-902. 2007..75% to 15.97% (5.94+/-6.10); alphaATP from 1.21% to 16.05% (7.04+/-6.14); betaATP from 1.01% to 7.12% (3.08+/-2.30). Brain mitochondrial activities were increased and more ATPs were produced after oxygen inhalation in healthy volunteers...
- Abnormal cardiac high-energy phosphate metabolism in a patient with type 2 diabetes mellitusMichaela Scheuermann-Freestone
Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, England
J Cardiometab Syndr 1:366-8. 2006
- Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stressIvan Luptak
Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Circulation 116:901-9. 2007..A shift of substrate preference toward glucose in the heart is considered a reversion to fetal metabolic profile, but its role in the pathogenesis of cardiac diseases is incompletely understood...
- Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained menThomas B Walker
Biosciences and Protection Division, Air Force Research Laboratory, Brooks City Base, TX 78235, USA
Metabolism 56:1111-7. 2007..In summary, there were no significant differences between groups for any of theparameters measured. Based on these results, we conclude that R rosea ingestion does not improve ATP turnover during or immediately after exercise...
- Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trialYuen Li Chung
King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
Arthritis Rheum 57:694-702. 2007....
- Prior exercise delays the onset of acidosis during incremental exerciseGraydon H Raymer
School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
J Appl Physiol 102:1799-805. 2007..5% PPO (SD 12.0) vs. Ramp 45.1% PPO (SD 9.1)]. In conclusion, prior heavy-intensity exercise delayed the onset of intracellular acidosis and enhanced exercise performance during a subsequent incremental exercise test...
- Investigations of back muscle fatigue by simultaneous 31P MRS and surface EMG measurementsReinhard Rzanny
AG Medizinische Physik, Institut für Diagnostische und Interventionelle Radiologie, Jena, Germany
Biomed Tech (Berl) 51:305-13. 2006..The results shed light on the interrelation of electrophysiological and metabolic changes during fatigue of the back muscle while performing an exercise...
- Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 TeslaJoseph Lee
Department of Medicine, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
J Magn Reson Imaging 24:1269-76. 2006..To develop a rapid, robust, and accurate method for assessing myocardial energetics in mice and demonstrate its applicability to mouse models of acquired and genetic heart disease...
- 31P NMR study of polyphosphate levels during different growth phases of Phycomyces blakesleeanusMiroslav Zivić
Institute of General and Physical Chemistry, Studentski trg 12 16, 11000 Belgrade, Serbia and Montenegro
Antonie Van Leeuwenhoek 91:169-77. 2007..Analysis of core polyphosphates, intracellular inorganic phosphate and beta-ATP signal intensities suggest the role of polyphosphates as an energy and/or a phosphate reserves during Phycomyces development...
- Non-invasive assessment of oxidative capacity in young Indian men and women: a 31P magnetic resonance spectroscopy studyPoonam Rana
NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences INMAS, Defence R and D Organisation, Brig S K Mazumdar Marg, Timarpur, Delhi 110054, India
Indian J Biochem Biophys 45:263-8. 2008..The results showed no gender effect on skeletal muscle oxidative metabolism. The study demonstrated the usefulness of such non-invasive method to indirectly measure the oxidative capacity of the muscle based on PCr recovery...
- A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRIF Vial
Laboratoire de Resonance Magnetique Nucleaire, INSERM U136, Faculte de Medecine de Tours, 2bis Boulevard Tonnellé, 37032 Tours Cedex, France
Magn Reson Imaging 22:457-65. 2004..9 (+/-10.1) at T+7 days (p < 0.01)]. This newborn piglet model of moderate HI brain injury with reproducible cerebral damage could be use as reference for the study of neuroprotective strategy for a period of 7 days...
- Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: implications for brain oedema in vivoJ H Bothwell
MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, Oxford, UK
J Neurochem 77:1632-40. 2001..In addition, the acidification of an intracellular compartment was observed during hypo-osmotic superfusion. Our results suggest a link between brain energy reserve and brain osmoregulation...
- Reduced oxidative phosphorylation and proton efflux suggest reduced capillary blood supply in skeletal muscle of patients with dermatomyositis and polymyositis: a quantitative 31P-magnetic resonance spectroscopy and MRI studyGabriel Cea
MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, Radcliffe Infirmary, University of Oxford, UK
Brain 125:1635-45. 2002..Our results suggest that the abnormal mitochondria seen in some muscle biopsies are unlikely to be the primary cause of the oxidative insufficiency in these patients...
- Age-dependent response of energy metabolism of human skin to UVA exposure: an in vivo study by 31P nuclear magnetic resonance spectroscopyLieve Declercq
Estée Lauder Coordination Center, Belgium
Skin Res Technol 8:125-32. 2002..The aim of our study was to evaluate the in vivo energy metabolism of human skin as a function of age, in conditions of rest and after a mild stress caused by a suberythemal UVA irradiation...
- Cardiac transplant patients response to the (31)P MRS stress testWilliam T Evanochko
Center for NMR Research and Development and the Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
J Heart Lung Transplant 21:522-9. 2002..If transient ischemia is invoked through the (31)P magnetic resonance spectroscopy (MRS) stress test, monitoring of such an event should be achievable and thus implicating possible ischemic involvement...
- Sublethal actions of copper in abalone (Haliotis rufescens) as characterized by in vivo 31P NMRMark R Viant
Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
Aquat Toxicol 57:139-51. 2002..In conclusion, abalone acutely exposed to copper pollution may develop asphyxial hypoxia. Since their survival is dependent on adherence to rock surfaces, such a reduction of muscle function could ultimately prove fatal...
- Oxygen supply and oxidative phosphorylation limitation in rat myocardium in situU Kreutzer
Department of Biological Chemistry, University of California, Davis, California 95616-8635, USA
Am J Physiol Heart Circ Physiol 280:H2030-7. 2001..Intracellular O2 supply does not limit MVO2, and the role of ADP in regulating respiration in rat myocardium in vivo remains an open question...
- Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanismR A Forbes
Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
Circ Res 88:802-9. 2001..These data suggest that the cardioprotective actions of diazoxide are mediated by generation of a pro-oxidant environment...
- Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscleAivaras Ratkevicius
NMR Center, Department of Medical Biochemistry and Genetics A, Panum Institute, University of Copenhagen, Blegdamsveg 3, DK 2200 Copenhagen N, Denmark
Muscle Nerve 25:419-26. 2002....
- High-energy phosphate metabolism in the exercising muscle of patients with peripheral arterial diseaseM Schocke
Department of Radiology, Innsbruck Medical University, Innsbruck, Austria michael
Vasa 37:199-210. 2008..This review summarizes the results of 31p MRS studies investigating the high-energy phosphate metabolism during ischemic exercise in healthy humans and during ramp or incremental exercise in PAD patients...
- Phosphorous metabolites and steady-state energetics of transformed fibroblasts during three-dimensional growthLeoni A Kunz-Schughart
Langham Resource, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
Am J Physiol Cell Physiol 283:C1287-97. 2002....
- Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopyMeinrad Beer
Institut für Röntgendiagnostik, Wurzburg, Germany
J Am Coll Cardiol 40:1267-74. 2002..The purpose of the present study was to measure absolute concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP) in normal, hypertrophied, and failing human heart...
- Dynamics of intramuscular 31P-MRS P(i) peak splitting and the slow components of PCr and O2 uptake during exerciseH B Rossiter
Department of Physiology, St George s Hospital Medical School, Tooting, London SW17 0RE, United Kingdom
J Appl Physiol 93:2059-69. 2002....
- Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivoDavid J Marcinek
Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195 7115, USA
Am J Physiol Heart Circ Physiol 285:H1900-8. 2003..Therefore, we reject a regulatory role for oxygen in cellular respiration and conclude that oxygen acts as a simple substrate for respiration under physiological conditions...
- 31P-MRS characterization of sprint and endurance trained athletesL Johansen
Team Danmark Testcenter, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Main Campus Odense University, Campusvej 55, 5230 Odense M, Denmark
Int J Sports Med 24:183-9. 2003....
- Decreasing ratios of phosphocreatine to beta-ATP correlates to progressive acute rejection in a concordant mouse heart to rat xenotransplantation modelD J Lukes
Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, , Sweden
Scand J Immunol 53:171-5. 2001..01). Further studies are indicated to establish the potential of (31)P MRS in immunosuppressed recipients of vascularized xenotransplants with prolonged graft survival...
- Preservation of rat skeletal muscle energy metabolism by illuminationAnn Lindgård
Department of Surgery and Plastic Surgery, Bioenergetics Group, Wallenberg Laboratory, Sahlgrenska University Hospital, Götenborg University, S 143 45 Götenborg, Sweden
Life Sci 72:2649-58. 2003..Illumination with SOE at 634 nm improved the preservation potential, in terms of a positive effect on the energy status of the muscle cell...
- A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophinM A Cole
MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
Neuromuscul Disord 12:247-57. 2002..The data indicate that the severe abnormalities which are present in the absence of utrophin and dystrophin leave basic muscle energetics intact and appear confined to processes involving the sarcolemma...
- Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo 31P NMR spectroscopyA V Naumova
Department of Radiology, Magnetic Resonance Research Division, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
Am J Physiol Heart Circ Physiol 285:H1976-9. 2003....
- Decreased high-energy phosphate ratios in the myocardium of men with diabetes mellitus type IBernhard Metzler
Division of Cardiology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
J Cardiovasc Magn Reson 4:493-502. 2002..Myocardial high-energy phosphates have been shown to be reduced by ischemia, and alterations of the cardiac metabolism are the primary consequence of myocardial ischemia...
- Relationship between cerebral interstitial levels of amino acids and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn pigletsTakashi Kusaka
Maternal and Perinatal Center, Kagawa Medical University, Mikicho 1750 1, Kitagun, Kagawa 761 0793, Japan
Pediatr Res 55:273-9. 2004..The cerebral energy state depended on the time course of changes in excitatory amino acids, suggesting that amino acids play distinct roles during the early and delayed phases of injury...
- Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophreniaStefan Smesny
Department of Psychiatry, Friedrich Schiller University Jena, Philosophenweg 3, D 07743 Jena, Germany
Neuroimage 35:729-37. 2007..Results support the notion of disturbed phospholipid turnover in schizophrenia, probably unrelated to prior pharmacological treatment, and associated with increased energy demand...
- Tannin structural elucidation and quantitative ³¹P NMR analysis. 1. Model compoundsFederica Melone
Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
J Agric Food Chem 61:9307-15. 2013....
- Determination of glucan phosphorylation using heteronuclear 1H, 13C double and 1H, 13C, 31P triple-resonance NMR spectraPeter Schmieder
Leibniz Institut fur Molekulare Pharmakologie FMP, Robert Rossle Str 10, D 13125, Berlin, Germany
Magn Reson Chem 51:655-61. 2013....
- Altered relative concentrations of high-energy phosphates in patients with uraemic cardiomyopathy measured by magnetic resonance spectroscopyRajan K Patel
Renal Research Group, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
Nephrol Dial Transplant 27:2446-51. 2012..We also assessed associations of HEP levels with abnormalities of uraemic cardiomyopathy...
- Improve the selectively refocused INEPT pulse sequence for detecting phosphomonoesters and phosphodiestersXi an Mao
Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
Magn Reson Med 68:332-8. 2012....
- Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferasesNicholas M Kanaan
Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
J Neurosci 31:9858-68. 2011..Results from these studies reveal a novel role for tau in modulating axonal phosphotransferases and provide a molecular basis for a toxic gain-of-function associated with pathogenic forms of tau...
- ³¹P-MRS studies of melanoma xenografts with different metastatic potentialLin Z Li
Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
Adv Exp Med Biol 701:69-73. 2011..The phosphomonoester (PME)/βNTP was higher in the more metastatic C8161 tumors (n=4) than in the less metastatic A375P tumors (n=4) (p < 0.1). No significant difference between the pHi of C8161 and A375P was observed...
- Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormonesJ G Pierce
Endocrinology 89:1331-44. 1971
- 31P NMR of phospholipid metabolites in prostate cancer and benign prostatic hyperplasiaRichard A Komoroski
Center for Imaging Research and Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0583, USA
Magn Reson Med 65:911-3. 2011..The high level of phosphoethanolamine+glycerophosphoethanolamine relative to phosphocholine+glycerophosphocholine suggests that the former may be significant contributors to the "total choline" resonance observed by (1)H MRSI in vivo...
- The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5A de Waard
Proc Natl Acad Sci U S A 54:1241-8. 1965
- RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysisJörg Rinnenthal
Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, Max von Laue Strasse 7, Frankfurt Main, Germany
J Biomol NMR 45:143-55. 2009..Nucleic Acids Res 36:1928-1940, 2008). Furthermore, the dynamics of the individual phosphate groups seem to be correlated to the 5' neighbouring nucleobases...
- Genotoxicity of environmentally relevant concentrations of water-soluble oil components in cod (Gadus morhua)Tor F Holth
Norwegian Institute for Water Research NIVA, CIENS, Gaustadalleen 21, NO 0349 Oslo, Norway
Environ Sci Technol 43:3329-34. 2009..The quantification of PAH metabolites in bile and hepatic DNA adduct formation appear to be suitable for environmental monitoring of chronic oil pollution...
- High-energy phosphates in the frontal lobe correlate with Wisconsin Card Sort Test performance in controls, not in schizophrenics: a 31phosphorus magnetic resonance spectroscopic and neuropsychological investigationH P Volz
Department of Psychiatry, University of Jena, Germany
Schizophr Res 31:37-47. 1998..This association was not found in schizophrenics, possibly due to the influence of neuroleptic medication or the disease process per se...
- Influence of the mode of insertion of SIV peptides into membranes on the structure of model membrane as studied by 31P NMRA Schanck
Unité de Chimie Physique Moléculaire et de Cristallographie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
Biochem Biophys Res Commun 250:12-4. 1998..This study reinforces the correlation between fusogenic activity, induction of structures not organized in extended bilayers, and calculated mode of insertion of peptides into lipid layers...
- Evaluation of the effects of photodynamic therapy with phosphorus 31 magnetic resonance spectroscopyM Nishiwaki
Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Handa cho Hamamatsu, Japan
Br J Cancer 80:133-41. 1999..0 when macroscopic recurrence occurred, while it stayed under 1.0 in complete response. This finding suggests that the recurrence of HeLa cell tumours can be detected by the PME/Pi ratio...
- Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscleA Heerschap
Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
Proc Nutr Soc 58:861-70. 1999....
- Investigation of hepatic gluconeogenesis pathway in non-diabetic Asian Indians with non-alcoholic fatty liver disease using in vivo ((31)P) phosphorus magnetic resonance spectroscopyRajeev Sharma
Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India
Atherosclerosis 203:291-7. 2009....
- (31)P solid-state MAS-NMR spectroscopy of the compounds that form in phosphate-bonded dental casting investment materials during settingSheelagh N Scrimgeour
Dental School, University of Dundee, Dundee, UK
Dent Mater 23:934-43. 2007..To determine whether they differ in material originating at the center of the mix from material that adheres to the mixing bowl wall...
- Synthesis of retinal ganglion cell phospholipids is under control of an endogenous circadian clock: daily variations in phospholipid-synthesizing enzyme activitiesE Garbarino-Pico
CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
J Neurosci Res 76:642-52. 2004..The results demonstrate that chicken RGCs contain circadian oscillators capable of generating metabolic oscillations in the biosynthesis of phospholipids autonomously...
- Phosphorus MRI of the Lower Extremeties in DiabeticsROBERT GREENMAN; Fiscal Year: 2003..abstract_text> ..
- The Effect of a Probiotic on Hepatic SteatosisSteven Solga; Fiscal Year: 2004..If the efficacy of probiotics is established one type of chronic liver disease, the possibility that similar biological therapies might benefit other chronic inflammatory states would merit further evaluation. ..
- Metabolic MRI of Diabetic Lower Extremity DiseaseRobert L Greenman; Fiscal Year: 2010....
- BRAINS Morphology and Image AnalysisVincent Magnotta; Fiscal Year: 2009....
- Feasibility of Rehabilitation Robots and fMRI in StrokeA Tzika; Fiscal Year: 2006..unreadable] [unreadable] [unreadable]..
- Restriction Endonuclease Structure and FunctionCYNTHIA DUPUREUR; Fiscal Year: 2005....
- Regulation of Neuronal Nicotinic ReceptorsLynn Wecker; Fiscal Year: 2005....
- FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)Britton Chance; Fiscal Year: 2005..These projects represent logical continuations of current activities into new and related researches. ..
- High-Res Multishot DTI by Real-Time NavigationEun Kee Jeong; Fiscal Year: 2006..abstract_text> ..
- 13th International Congress of Radiation ResearchMark Dewhirst; Fiscal Year: 2007..unreadable] [unreadable] [unreadable] [unreadable]..
- IMP Dehydrogenase and the Hydra of Cancer ChemotherapyGEORGE MARKHAM; Fiscal Year: 2008..These results will reveal the inner working of an essential enzyme and whether there is promise for enhancing clinical efficacy through combinations of known drugs or the discovery of novel subdomain ligands. ..
- Image-Guided Pro-Drug/Enzyme TherapyZaver Bhujwalla; Fiscal Year: 2008..unreadable] [unreadable] [unreadable]..
- Applications of Field-Cycling NMR to Studies of BiomoleculesAlfred Redfield; Fiscal Year: 2008..We will obtain new information about physical arrangements in these systems, and especially about dynamics of small molecules (substrates and inhibitors) weakly bound to enzymes. ..
- High Resolution DTI Using 3D Single-Shot AcquisitionEun Kee Jeong; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Brain Phospholipid Composition in SchizophreniaRichard Komoroski; Fiscal Year: 2004..It will also potentially provide support and clarification for several aspects of the membrane hypothesis of schizophrenia. ..
- BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDEBritton Chance; Fiscal Year: 2002..If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified. ..
- PURCHASE OF A MALDI-TOF MASS SPECTROMETERChristine Chow; Fiscal Year: 2002..The CIF provides Ph.D.-level expertise in mass spectral techniques, and several in-house experts on mass spectrometry and MALDI-TOF will play key advisory roles. ..
- DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRSWei Chen; Fiscal Year: 2002..abstract_text> ..
- SOLID STATE NMR STUDIES OF DNA AND RNA DYNAMICSGary Drobny; Fiscal Year: 2002..6 Tesla by completing construction of a multi-resonant CPMAS probe, thus aiding in the completion of specific goals 1-4; 5) Synthesize all isotopically labeled DNA and RNA phosphoramidites required to achieve specific goals 1-4. ..
- MULTIDICIPLINARY FUNCTIONAL IMAGING OF CANCERZaver Bhujwalla; Fiscal Year: 2002..abstract_text> ..
- INTERFACIAL ACTIVATION OF WATER SOLUBLE PHOSPHOLIPASESMary Roberts; Fiscal Year: 2003..abstract_text> ..
- A Study of Site-Specifically Modified RNAsChristine Chow; Fiscal Year: 2006..abstract_text> ..
- Sleep, Circadian Rhythms and Dementing IllnessesDavid Harper; Fiscal Year: 2007..abstract_text> ..
- RESPIRATION AND GLYCOLYSIS--INTEGRATION IN ACTIVE MUSCLEKevin Conley; Fiscal Year: 2002..g., diabetes. An understanding of the integration of metabolism in healthy tissue is the first step to understanding how failure of integration limits function in diseased muscle. ..
- FcR Mutations in Kawasaki DiseaseMichael Portman; Fiscal Year: 2008....
- UW Stipends for Training Aspiring Researchers (STAR)Michael Portman; Fiscal Year: 2008..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..
- ENZYMATIC MECHANISMS OF SULFUR NUCLEOSIDE METABOLISMGEORGE MARKHAM; Fiscal Year: 2008..These studies will unmask why nature conserves use of a pyruvoyl cofactor for this metabolic function instead of adopting the common pyridoxal cofactor. ..
- COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICALBritton Chance; Fiscal Year: 2002..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
- Mitochondrial Dysfunction in Aged MuscleDavid J Marcinek; Fiscal Year: 2010..2) Our long-term goal is the development of non- invasive methods to diagnose mitochondrial dysfunction and follow the progress of interventions meant to reverse disability in the elderly. ..
- A Non-invasive Single-trial In-vivo Neuroimaging SystemPaul Sajda; Fiscal Year: 2007..3.Demonstrate that stEEG/tMRI activations maps yield new information for discriminating young and old adult populations, as compared to traditional efMRI and P3 and ERN ERP analysis. ..
- Depression and Brain MetabolismDan Iosifescu; Fiscal Year: 2007..The development of a larger scale R01 project investigating the role of brain energy metabolism in a population of treatment-resistant subjects with MDD will be started during the last two years of the award period. ..
- FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKSWei Chen; Fiscal Year: 2003..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
- Images of Quantified Hypoxic Stress in MuscleBritton Chance; Fiscal Year: 2005..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
- PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRIWei Chen; Fiscal Year: 2005....
- Imaging Lymphatic Clearance in Tumor MetastasisZaver Bhujwalla; Fiscal Year: 2003..abstract_text> ..
- Myoglobin as an indicator of hpoxia toleranceSTEPHEN KINSEY; Fiscal Year: 2006..unreadable] [unreadable] [unreadable] [unreadable]..
- Triostat in Children During CPBMichael Portman; Fiscal Year: 2007..unreadable]..
- DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRSWei Chen; Fiscal Year: 2003..abstract_text> ..
- 2 & 3D Imaging of Contrast Agents in Animal ModelsBritton Chance; Fiscal Year: 2004..abstract_text> ..
- COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICALBritton Chance; Fiscal Year: 2003..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
- Novel RF Coils for In Vivo MR Applications at High FieldWei Chen; Fiscal Year: 2007..abstract_text> ..