phosphorus isotopes

Summary

Summary: Stable phosphorus atoms that have the same atomic number as the element phosphorus, but differ in atomic weight. P-31 is a stable phosphorus isotope.

Top Publications

  1. ncbi Skeletal muscle energetics with PNMR: personal views and historic perspectives
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    NMR Biomed 19:904-26. 2006
  2. ncbi Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxia
    Christian Wolf
    Department of Radiology I, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Mol Imaging Biol 10:24-9. 2008
  3. pmc Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements
    Ian R Lanza
    Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 34:1143-50. 2011
  4. ncbi Assessment of (31)P relaxation times in the human calf muscle: a comparison between 3 T and 7 T in vivo
    W Bogner
    Department of Radiology, Medical University Vienna, Vienna, Austria
    Magn Reson Med 62:574-82. 2009
  5. ncbi Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates
    Nicole M A van den Broek
    Biomedical NMR, Dept of Biomedical Engineering, Eindhoven University of Technology, N laag b1 08, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Am J Physiol Cell Physiol 293:C228-37. 2007
  6. pmc 31P saturation transfer spectroscopy predicts differential intracellular macromolecular association of ATP and ADP in skeletal muscle
    Christine Nabuurs
    Department of Radiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 285:39588-96. 2010
  7. pmc Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy
    Douglas E Befroy
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Methods Enzymol 457:373-93. 2009
  8. ncbi 31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy
    Tina Dysgaard Jeppesen
    Neuromuscular Research Unit, Section 7611, National University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    J Neurol 254:29-37. 2007
  9. ncbi Soil and litter phosphorus-31 nuclear magnetic resonance spectroscopy: extractants, metals, and phosphorus relaxation times
    B J Cade-Menun
    Dep of Environmental Sciences, Policy and Management, Univ of California at Berkeley, USA
    J Environ Qual 31:457-65. 2002
  10. ncbi Dynamic MRS and MRI of skeletal muscle function and biomechanics
    Jeanine J Prompers
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    NMR Biomed 19:927-53. 2006

Research Grants

  1. Phosphorus MRI of the Lower Extremeties in Diabetics
    ROBERT GREENMAN; Fiscal Year: 2003
  2. The Effect of a Probiotic on Hepatic Steatosis
    Steven Solga; Fiscal Year: 2004
  3. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
  4. BRAINS Morphology and Image Analysis
    Vincent Magnotta; Fiscal Year: 2009
  5. Feasibility of Rehabilitation Robots and fMRI in Stroke
    A Tzika; Fiscal Year: 2006
  6. Restriction Endonuclease Structure and Function
    CYNTHIA DUPUREUR; Fiscal Year: 2005
  7. Regulation of Neuronal Nicotinic Receptors
    Lynn Wecker; Fiscal Year: 2005
  8. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2005
  9. High-Res Multishot DTI by Real-Time Navigation
    Eun Kee Jeong; Fiscal Year: 2006
  10. 13th International Congress of Radiation Research
    Mark Dewhirst; Fiscal Year: 2007

Detail Information

Publications189 found, 100 shown here

  1. ncbi Skeletal muscle energetics with PNMR: personal views and historic perspectives
    Britton Chance
    Department of Biochemistry and Biophysics, University of Pennsylvania, Philadelphia, PA 19104 6059, USA
    NMR Biomed 19:904-26. 2006
    ..Some of the research has been introduced in exercise physiology. Future directions of NMR on bioenergetics, as a part of system biological approaches, are indicated...
  2. ncbi Phosphorus-31 two-dimensional chemical shift imaging in the myocardium of patients with late onset of Friedreich ataxia
    Christian Wolf
    Department of Radiology I, Innsbruck Medical University, Anichstrasse 35, 6020 Innsbruck, Austria
    Mol Imaging Biol 10:24-9. 2008
    ..The purpose of this study was to investigate cardiac function and high-energy phosphate metabolism in FRDA patients with late disease onset...
  3. pmc Measurement of human skeletal muscle oxidative capacity by 31P-MR spectroscopy: a cross-validation with in vitro measurements
    Ian R Lanza
    Division of Endocrinology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Magn Reson Imaging 34:1143-50. 2011
    ..To cross-validate skeletal muscle oxidative capacity measured by (31)P-MR spectroscopy with in vitro measurements of oxidative capacity in mitochondria isolated from muscle biopsies of the same muscle group in 18 healthy adults...
  4. ncbi Assessment of (31)P relaxation times in the human calf muscle: a comparison between 3 T and 7 T in vivo
    W Bogner
    Department of Radiology, Medical University Vienna, Vienna, Austria
    Magn Reson Med 62:574-82. 2009
    ..2 Hz to 11.2 +/- 1.9 Hz or +72%. At 7 T (31)P-MRS in the human calf muscle offers more than twice as much SNR per unit time in reduced measurement time compared to 3 T. This will facilitate in vivo (31)P-MRS of the human muscle at 7 T...
  5. ncbi Intersubject differences in the effect of acidosis on phosphocreatine recovery kinetics in muscle after exercise are due to differences in proton efflux rates
    Nicole M A van den Broek
    Biomedical NMR, Dept of Biomedical Engineering, Eindhoven University of Technology, N laag b1 08, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Am J Physiol Cell Physiol 293:C228-37. 2007
    ..Our study implies that simply correcting tau(PCr) for end-exercise pH is not adequate, in particular when comparing patients and control subjects, because certain disorders are characterized by altered proton efflux from muscle fibers...
  6. pmc 31P saturation transfer spectroscopy predicts differential intracellular macromolecular association of ATP and ADP in skeletal muscle
    Christine Nabuurs
    Department of Radiology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Biol Chem 285:39588-96. 2010
    ..We present a model, matching the experimental result, for ADP ↔ ATP exchange, in which ADP is only transiently present in the cytosol...
  7. pmc Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy
    Douglas E Befroy
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Methods Enzymol 457:373-93. 2009
    ..We will also examine applications of the techniques to investigate how these parameters of muscle mitochondrial metabolism are modulated in insulin resistant and endurance trained individuals...
  8. ncbi 31P-MRS of skeletal muscle is not a sensitive diagnostic test for mitochondrial myopathy
    Tina Dysgaard Jeppesen
    Neuromuscular Research Unit, Section 7611, National University Hospital, Rigshospitalet, Blegdamsvej 9, 2100, Copenhagen, Denmark
    J Neurol 254:29-37. 2007
    ..Thus, (31)P-MRS should not be a routine test for MM, but may be an important research tool...
  9. ncbi Soil and litter phosphorus-31 nuclear magnetic resonance spectroscopy: extractants, metals, and phosphorus relaxation times
    B J Cade-Menun
    Dep of Environmental Sciences, Policy and Management, Univ of California at Berkeley, USA
    J Environ Qual 31:457-65. 2002
    ....
  10. ncbi Dynamic MRS and MRI of skeletal muscle function and biomechanics
    Jeanine J Prompers
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, The Netherlands
    NMR Biomed 19:927-53. 2006
    ....
  11. ncbi Early or advanced stage type 2 diabetes is not accompanied by in vivo skeletal muscle mitochondrial dysfunction
    H M De Feyter
    Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, PO Box 513, 5600 MB Eindhoven, The Netherlands
    Eur J Endocrinol 158:643-53. 2008
    ....
  12. ncbi Comparison of measuring energy metabolism by different (31) P-magnetic resonance spectroscopy techniques in resting, ischemic, and exercising muscle
    Albrecht I Schmid
    MR Center of Excellence, Medical University of Vienna, Vienna, Austria
    Magn Reson Med 67:898-905. 2012
    ..Magn Reson Med, 2011. © 2011 Wiley-Liss, Inc...
  13. ncbi 31P MRS measurement of mitochondrial function in skeletal muscle: reliability, force-level sensitivity and relation to whole body maximal oxygen uptake
    D E Larson-Meyer
    Department of Nutrition Sciences, Division of Physiology and Metabolism, The University of Alabama at Birmingham, Birmingham, AL 35205, USA
    NMR Biomed 13:14-27. 2000
    ..41-0.72; p < 0.05). These results suggest that measurements of TC(PCr), TC(ADP) and OxPhos yield reproducible results that correlate with whole-body VO(2max) and that vary in force-level sensitivity...
  14. ncbi Impaired in vivo mitochondrial function but similar intramyocellular lipid content in patients with type 2 diabetes mellitus and BMI-matched control subjects
    V B Schrauwen-Hinderling
    Department of Radiology, University Hospital Maastricht, P O Box 5800, 6202 AZ, Maastricht, The Netherlands
    Diabetologia 50:113-20. 2007
    ..As obesity is an independent determinant of IMCL content, we examined mitochondrial function and IMCL content in overweight type 2 diabetes patients and BMI-matched normoglycaemic controls...
  15. ncbi Abnormal cardiac and skeletal muscle energy metabolism in patients with type 2 diabetes
    Michaela Scheuermann-Freestone
    Department of Biochemistry, University of Oxford, Oxford OX1 3PT, England
    Circulation 107:3040-6. 2003
    ..It is well known that patients with type 2 diabetes have increased risk of cardiovascular disease, but it is not known whether they have underlying abnormalities in cardiac or skeletal muscle high-energy phosphate metabolism...
  16. pmc Phosphocreatine recovery kinetics following low- and high-intensity exercise in human triceps surae and rat posterior hindlimb muscles
    Sean C Forbes
    Dept of Physiology 2201 BPS Bldg, Michigan State Univ, East Lansing, MI 48824, USA
    Am J Physiol Regul Integr Comp Physiol 296:R161-70. 2009
    ..In addition, the observation of a fast component following high-intensity exercise is consistent with the notion that glycolytic ATP production contributes to PCr resynthesis during the initial stage of recovery...
  17. ncbi Oxidative ATP synthesis in skeletal muscle is controlled by substrate feedback
    Fan Wu
    Department of Physiology, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, USA
    Am J Physiol Cell Physiol 292:C115-24. 2007
    ....
  18. pmc Tightly coupled brain activity and cerebral ATP metabolic rate
    Fei Du
    Department of Radiology, Center for Magnetic Resonance Research and Department of Biomedical Engineering, University of Minnesota Medical School, Minneapolis, MN 55455, USA
    Proc Natl Acad Sci U S A 105:6409-14. 2008
    ....
  19. ncbi Defective brain and muscle energy metabolism shown by in vivo 31P magnetic resonance spectroscopy in nonaffected carriers of 11778 mtDNA mutation
    B Barbiroli
    Cattedra di Biochimica Clinica, , Italy
    Neurology 45:1364-9. 1995
    ..All subjects without mutation had normal brain and muscle MRS. 31P-MRS disclosed defective bioenergetics in the brain or muscle or both of all asymptomatic carriers studied from our pedigree...
  20. ncbi Quantitative ATP synthesis in human liver measured by localized 31P spectroscopy using the magnetization transfer experiment
    A I Schmid
    Karl Landsteiner Institute of Endocrinology and Metabolism, Hanusch Hospital, Vienna, Austria
    NMR Biomed 21:437-43. 2008
    ..In conclusion, 31P MRS at 3 T provides sufficient sensitivity to detect magnetization transfer effects and can therefore be used to assess ATP synthesis in human liver...
  21. ncbi 31P MR spectroscopy and in vitro markers of oxidative capacity in type 2 diabetes patients
    S F E Praet
    Department of Movement Sciences, Nutrition and Toxicology Research Institute Maastricht, Maastricht University, 6200, MD, Maastricht, The Netherlands
    MAGMA 19:321-31. 2006
    ..However, microvascular co-morbidity in long-standing T2D can interfere with the (31)P MRS methodology...
  22. ncbi Reduced rate of adenosine triphosphate synthesis by in vivo 31P nuclear magnetic resonance spectroscopy and downregulation of PGC-1beta in distal skeletal muscle following burn
    A Aria Tzika
    Department of Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Mol Med 21:201-8. 2008
    ..That PGC-1beta is a highly inducible factor in most tissues and responds to common calcium and cyclic adenosine monophosphate (cAMP) signaling pathways strongly suggests that it may be possible to develop drugs that can induce PGC-1beta...
  23. ncbi Reproducibility assessment of metabolic variables characterizing muscle energetics in vivo: A 31P-MRS study
    Gwenael Layec
    Centre de Resonance Magnetique Biologique et Medicale, UMR CNRS 6612, Faculte de Medecine de Marseille, Marseille, France
    Magn Reson Med 62:840-54. 2009
    ..In addition, the corresponding metabolic measurements can reliably be used for longitudinal studies performed even over a long period of time...
  24. ncbi Three-dimensional high-resolution magnetic resonance spectroscopic imaging for absolute quantification of 31P metabolites in human liver
    M Chmelik
    Karl Landsteiner Institute for Endocrinology and Metabolism, Vienna, Austria
    Magn Reson Med 60:796-802. 2008
    ..This method allows for examination of regional deviations of energy metabolism in human liver diseases...
  25. ncbi BII nucleotides in the B and C forms of natural-sequence polymeric DNA: A new model for the C form of DNA
    L van Dam
    Department of Physical Chemistry Arrhenius Laboratory, Stockholm University, Stockholm, S 106 91, Sweden
    J Mol Biol 304:541-61. 2000
    ..This work shows that the B to C transition in fibers corresponds to BI to BII conformational changes of the individual nucleotides...
  26. ncbi Butyrate impairs energy metabolism in isolated perfused liver of fed rats
    M C Beauvieux
    Service de Nutrition et Diabétologie, Hopital Haut Leveque, F 33600 Pessac France
    J Nutr 131:1986-92. 2001
    ..In conclusion, the difference in the hepatic oxidation pathways of two products of intestinal fermentation (acetate and butyrate) explains their different actions on energy metabolism...
  27. ncbi MR spectroscopy in heart failure
    Cameron Holloway
    Department of Physiology, Anatomy and Genetics, University of Oxford, United Kingdom
    Front Biosci (Schol Ed) 3:331-40. 2011
    ..MRS signals from 31P, 1H, 23Na and 13C, including novel hyperpolarization techniques, have provided considerable insight into the understanding of energy metabolism in the healthy and diseased heart...
  28. pmc Measuring the acute effect of insulin infusion on ATP turnover rate in human skeletal muscle using phosphorus-31 magnetic resonance saturation transfer spectroscopy
    Ee Lin Lim
    Institute of Cellular Medicine, Newcastle Magnetic Resonance Centre, Newcastle University, Newcastle upon Tyne, UK
    NMR Biomed 23:952-7. 2010
    ..03 vs baseline). The in vivo time course of insulin stimulation of skeletal muscle ATP turnover rate is not consistent with a rate limiting effect upon the initiation of insulin-stimulated glycogen synthesis...
  29. ncbi Measurement of intracellular (compartmental) pH by 31P NMR in Aspergillus niger
    S J Hesse
    Department of Molecular Physics, Wageningen Agricultural University, The Netherlands
    J Biotechnol 77:5-15. 2000
    ..6 and 1.4, respectively)...
  30. ncbi Efficient in vivo 31P magnetization transfer approach for noninvasively determining multiple kinetic parameters and metabolic fluxes of ATP metabolism in the human brain
    Fei Du
    Center for Magnetic Resonance Research, Department of Radiology, University of Minnesota, Minneapolis, Minnesota 55455, USA
    Magn Reson Med 57:103-14. 2007
    ..The MSS MT approach should provide an important modality for noninvasively studying the essential roles of ATP metabolism in brain bioenergetics, function, and diseases...
  31. ncbi P-31 magnetic resonance spectroscopy. A tool for diagnostic purposes and pathophysiological insights in muscle diseases
    J P Mattei
    Centre de Resonance Magnetique Biologique et Medicale, CRMBM, UMR CNRS 6612, Faculte de Medecine, Marseille, France
    Reumatismo 56:9-14. 2004
    ..Finally, the contribution of 31P MRS to our understanding of the physiopathology of several other diseases is highlighted...
  32. pmc Restoration of muscle mitochondrial function and metabolic flexibility in type 2 diabetes by exercise training is paralleled by increased myocellular fat storage and improved insulin sensitivity
    Ruth C R Meex
    Department of Human Movement Sciences, NUTRIM School for Nutrition, Toxicology and Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands
    Diabetes 59:572-9. 2010
    ..We examined whether exercise training could restore mitochondrial function and insulin sensitivity in patients with type 2 diabetes...
  33. ncbi Abnormal mitochondrial function and muscle wasting, but normal contractile efficiency, in haemodialysed patients studied non-invasively in vivo
    Graham J Kemp
    Department of Musculoskeletal Science, University of Liverpool, Liverpool L69 3GA, UK
    Nephrol Dial Transplant 19:1520-7. 2004
    ....
  34. ncbi Nm23-transfected MDA-MB-435 human breast carcinoma cells form tumors with altered phospholipid metabolism and pH: a 31P nuclear magnetic resonance study in vivo and in vitro
    Z M Bhujwalla
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 41:897-903. 1999
    ..These results suggest that nm23 genes may affect suppression of metastasis through phospholipid-mediated signaling and cellular pH regulation...
  35. ncbi Noninvasive measurements of cardiac high-energy phosphate metabolites in dilated cardiomyopathy by using 31P spectroscopic chemical shift imaging
    A Hansch
    Institute of Diagnostic and Interventional Radiology, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany
    Eur Radiol 15:319-23. 2005
    ..In addition to reduced PCr/ATP ratios observed in patients suffering from DCM, significantly-increased PDE/ATP ratios were found in patients with severe DCM...
  36. ncbi [Non-invasive investigation of muscle function using 31P magnetic resonance spectroscopy and 1H MR imaging]
    D Bendahan
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS No 6612, Faculte de Medecine de Marseille
    Rev Neurol (Paris) 162:467-84. 2006
    ..As a research tool, it will keep bringing new information on the physiopathology of muscle diseases in animal models and in humans and should play a role in the metabolic characterization of gene and cell therapy...
  37. ncbi Basal ganglia high-energy phosphate metabolism in neuroleptic-naive patients with schizophrenia: a 31-phosphorus magnetic resonance spectroscopic study
    B N Gangadhar
    Department of Neuroimaging and Interventional Radiology, National Institute of Mental Health and Neurosciences, Hosur Road, 560 029 Bangalore, India
    Am J Psychiatry 161:1304-6. 2004
    ..This study used 31-phosphorus magnetic resonance spectroscopy ((31)P MRS) to investigate basal ganglia abnormalities in neuroleptic-naive patients with schizophrenia...
  38. ncbi Variations due to analysis technique in intracellular pH measurements in simulated and in vivo 31P MR spectra of the human brain
    Gavin Hamilton
    Robert Steiner MR Unit, Imaging Sciences Department, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College London, London, United Kingdom
    J Magn Reson Imaging 23:459-64. 2006
    ..Three different methods were used to measure the chemical shift of inorganic phosphate (Pi) relative to phosphocreatine (PCr)...
  39. ncbi 31P MRS of heart grafts provides metabolic markers of early dysfunction
    Thierry Caus
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Fac Med, 27 Bd Jean Moulin, 13005 Marseille, France
    Eur J Cardiothorac Surg 28:576-80. 2005
    ..We tested whether selected metabolic markers, including high-energy phosphate concentrations measured ex vivo in pre-transplant heart grafts by (31)P magnetic resonance spectroscopy (MRS) are related with early post-transplant outcome...
  40. ncbi Non-invasive diagnostic of cardiac allograft vasculopathy by 31P magnetic resonance chemical shift imaging
    Thierry Caus
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Faculte de Medecine, 27 Bd Jean Moulin, 13005 Marseille, France
    Eur J Cardiothorac Surg 29:45-9. 2006
    ..In this study, we assessed whether 31P magnetic resonance chemical shift imaging can diagnose CAV by studying variations in cardiac high-energy phosphates in a population of adult heart transplant recipients...
  41. ncbi New experimental setup for studying strictly noninvasively skeletal muscle function in rat using 1H-magnetic resonance (MR) imaging and 31P-MR spectroscopy
    Benoit Giannesini
    Centre de Résonance Magnétique Biologique et Médicale CRMBM, UMR CNRS 6612, Faculte de Medecine de Marseille, Marseille, France
    Magn Reson Med 54:1058-64. 2005
    ..This opens up new perspectives in various research areas including pharmaceutical research...
  42. ncbi Direct action of T3 on phosphorylation potential in the sheep heart in vivo
    Michael A Portman
    Division of Cardiology, Department of Pediatrics, University of Washington School of Medicine, Seattle, Wahington 98105, USA
    Am J Physiol Heart Circ Physiol 288:H2484-90. 2005
    ..These T3-induced effects are not due to changes in ADP/ATP exchange efficiency through action at the adenine nucleotide translocator but may be due to T3 mediation of substrate utilization, confirmed in other models...
  43. ncbi Detection of myocardial infarctions by acquisition-weighted 31P-MR spectroscopy in humans
    Meinrad Beer
    Institut für Röntgendiagnostik, Universitat Wurzburg, Wurzburg, Germany
    J Magn Reson Imaging 20:798-802. 2004
    ..To determine whether the recently applied technique of acquisition-weighted 31P-MR spectroscopy (AW-MRS) allows for the detection of depressed energy metabolism in patients with inferior wall myocardial infarctions...
  44. ncbi A technique for the measurement of renal ATP in a large animal model of septic shock
    C May
    Howard Florey Institute, University of Melbourne, Parkville, Australia
    Int J Artif Organs 28:16-21. 2005
    ..The mechanisms responsible for acute renal failure in sepsis are not understood. Measurement of tissue ATP might help to understand this process but, in the large animal, it is hampered by major technical difficulties...
  45. ncbi Brain energetics and tolerance to anoxia in deep hypothermia
    Radoslav K Andjus
    University of Belgrade, Yugoslavia
    Ann N Y Acad Sci 1048:10-35. 2005
    ..The results contribute to the understanding of the role of brain energetics in tolerance to oxygen deprivation...
  46. ncbi The influence of tissue blood flow volume on energy metabolism in masseter muscles
    Kazuki Okada
    Dept of Gnathofunctional Medicine, Graduate School of Dental Medicine, Hokkaido University, West 7 North 13, Kita ku, Sapporo 060 8586, Japan
    Cranio 23:166-73. 2005
    ....
  47. ncbi Metabolism of perfused pig intercostal muscles evaluated by 31P-magnetic resonance spectroscopy
    Brian Lindegaard Pedersen
    Nuclear Magnetic Resonance Centre, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3, 2200 Copenhagen N, Denmark
    Exp Physiol 91:755-63. 2006
    ..The preparation can also be applied to human intercostal muscles, as demonstrated in one preliminary experiment. The results demonstrate a stable and functional in vitro preparation of intact perfused intercostal muscles in the pig...
  48. ncbi Heart slice NMR
    Tadayuki Uetani
    Department of Cell Physiology, Nagoya University Graduate School of Medicine, Nagoya 466 8550, Japan
    Am J Physiol Heart Circ Physiol 292:H1181-6. 2007
    ..Heart slice preparation could also be used to evaluate the potency of cardiac drugs, regardless of their possible effects on coronary microcirculation...
  49. ncbi In vivo modular control analysis of energy metabolism in contracting skeletal muscle
    Laurent M Arsac
    Résonance Magnétique des Systèmes Biologiques, UMR 5536 CNRS Centre National de la Recherche Scientifique, Universite Bordeaux 2, Bordeaux, France
    Biochem J 414:391-7. 2008
    ....
  50. ncbi Impaired resting muscle energetics studied by (31)P-NMR in diet-induced obese rats
    Emilie Chanseaume
    INRA, UMR1019, Clermont Ferrand, France
    Obesity (Silver Spring) 16:572-7. 2008
    ..For that purpose, we used in vivo (31)P-nuclear magnetic resonance ((31)P-NMR) in male sedentary Wistar rats fed with obesogenic diets known to induce alterations in muscle mitochondrial activity...
  51. ncbi Parallel increases in phosphocreatine and total creatine in human vastus lateralis muscle during creatine supplementation
    Jeffrey J Brault
    Dept of Physiology, Michigan State University, East Lansing, MI 48824, USA
    Int J Sport Nutr Exerc Metab 17:624-34. 2007
    ..TCr (14.9% +/- 4.1%) at any time point. The results indicate that creatine supplementation does not alter the PCr:TCr ratio, and hence the cytoplasmic Gibbs free energy of ATP hydrolysis, in human skeletal muscle at rest...
  52. ncbi Evidence of brain mitochondrial activities after oxygen inhalation by 31P magnetic resonance spectroscopy at 3T
    Ren Hua Wu
    Department of Medical Imaging, Shantou University Medical College, China
    Conf Proc IEEE Eng Med Biol Soc 2007:2899-902. 2007
    ..75% to 15.97% (5.94+/-6.10); alphaATP from 1.21% to 16.05% (7.04+/-6.14); betaATP from 1.01% to 7.12% (3.08+/-2.30). Brain mitochondrial activities were increased and more ATPs were produced after oxygen inhalation in healthy volunteers...
  53. ncbi Abnormal cardiac high-energy phosphate metabolism in a patient with type 2 diabetes mellitus
    Michaela Scheuermann-Freestone
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, England
    J Cardiometab Syndr 1:366-8. 2006
  54. ncbi Long-term effects of increased glucose entry on mouse hearts during normal aging and ischemic stress
    Ivan Luptak
    Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 116:901-9. 2007
    ..A shift of substrate preference toward glucose in the heart is considered a reversion to fetal metabolic profile, but its role in the pathogenesis of cardiac diseases is incompletely understood...
  55. ncbi Failure of Rhodiola rosea to alter skeletal muscle phosphate kinetics in trained men
    Thomas B Walker
    Biosciences and Protection Division, Air Force Research Laboratory, Brooks City Base, TX 78235, USA
    Metabolism 56:1111-7. 2007
    ..In summary, there were no significant differences between groups for any of theparameters measured. Based on these results, we conclude that R rosea ingestion does not improve ATP turnover during or immediately after exercise...
  56. ncbi Creatine supplements in patients with idiopathic inflammatory myopathies who are clinically weak after conventional pharmacologic treatment: Six-month, double-blind, randomized, placebo-controlled trial
    Yuen Li Chung
    King s College London School of Medicine, and the MRC Clinical Science Centre, Hammersmith Hospital, Imperial College School of Medicine, London, UK
    Arthritis Rheum 57:694-702. 2007
    ....
  57. ncbi Prior exercise delays the onset of acidosis during incremental exercise
    Graydon H Raymer
    School of Kinesiology, The University of Western Ontario, London, Ontario, Canada N6A 3K7
    J Appl Physiol 102:1799-805. 2007
    ..5% PPO (SD 12.0) vs. Ramp 45.1% PPO (SD 9.1)]. In conclusion, prior heavy-intensity exercise delayed the onset of intracellular acidosis and enhanced exercise performance during a subsequent incremental exercise test...
  58. ncbi Investigations of back muscle fatigue by simultaneous 31P MRS and surface EMG measurements
    Reinhard Rzanny
    AG Medizinische Physik, Institut für Diagnostische und Interventionelle Radiologie, Jena, Germany
    Biomed Tech (Berl) 51:305-13. 2006
    ..The results shed light on the interrelation of electrophysiological and metabolic changes during fatigue of the back muscle while performing an exercise...
  59. ncbi Open-chest 31P magnetic resonance spectroscopy of mouse heart at 4.7 Tesla
    Joseph Lee
    Department of Medicine, University of Minnesota Academic Health Center, Minneapolis, Minnesota 55455, USA
    J Magn Reson Imaging 24:1269-76. 2006
    ..To develop a rapid, robust, and accurate method for assessing myocardial energetics in mice and demonstrate its applicability to mouse models of acquired and genetic heart disease...
  60. ncbi 31P NMR study of polyphosphate levels during different growth phases of Phycomyces blakesleeanus
    Miroslav Zivić
    Institute of General and Physical Chemistry, Studentski trg 12 16, 11000 Belgrade, Serbia and Montenegro
    Antonie Van Leeuwenhoek 91:169-77. 2007
    ..Analysis of core polyphosphates, intracellular inorganic phosphate and beta-ATP signal intensities suggest the role of polyphosphates as an energy and/or a phosphate reserves during Phycomyces development...
  61. ncbi Non-invasive assessment of oxidative capacity in young Indian men and women: a 31P magnetic resonance spectroscopy study
    Poonam Rana
    NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences INMAS, Defence R and D Organisation, Brig S K Mazumdar Marg, Timarpur, Delhi 110054, India
    Indian J Biochem Biophys 45:263-8. 2008
    ..The results showed no gender effect on skeletal muscle oxidative metabolism. The study demonstrated the usefulness of such non-invasive method to indirectly measure the oxidative capacity of the muscle based on PCr recovery...
  62. ncbi A newborn piglet study of moderate hypoxic-ischemic brain injury by 1H-MRS and MRI
    F Vial
    Laboratoire de Resonance Magnetique Nucleaire, INSERM U136, Faculte de Medecine de Tours, 2bis Boulevard Tonnellé, 37032 Tours Cedex, France
    Magn Reson Imaging 22:457-65. 2004
    ..9 (+/-10.1) at T+7 days (p < 0.01)]. This newborn piglet model of moderate HI brain injury with reproducible cerebral damage could be use as reference for the study of neuroprotective strategy for a period of 7 days...
  63. ncbi Hypo-osmotic swelling-activated release of organic osmolytes in brain slices: implications for brain oedema in vivo
    J H Bothwell
    MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, University of Oxford, Oxford, UK
    J Neurochem 77:1632-40. 2001
    ..In addition, the acidification of an intracellular compartment was observed during hypo-osmotic superfusion. Our results suggest a link between brain energy reserve and brain osmoregulation...
  64. ncbi Reduced oxidative phosphorylation and proton efflux suggest reduced capillary blood supply in skeletal muscle of patients with dermatomyositis and polymyositis: a quantitative 31P-magnetic resonance spectroscopy and MRI study
    Gabriel Cea
    MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, Radcliffe Infirmary, University of Oxford, UK
    Brain 125:1635-45. 2002
    ..Our results suggest that the abnormal mitochondria seen in some muscle biopsies are unlikely to be the primary cause of the oxidative insufficiency in these patients...
  65. ncbi Age-dependent response of energy metabolism of human skin to UVA exposure: an in vivo study by 31P nuclear magnetic resonance spectroscopy
    Lieve Declercq
    Estée Lauder Coordination Center, Belgium
    Skin Res Technol 8:125-32. 2002
    ..The aim of our study was to evaluate the in vivo energy metabolism of human skin as a function of age, in conditions of rest and after a mild stress caused by a suberythemal UVA irradiation...
  66. ncbi Cardiac transplant patients response to the (31)P MRS stress test
    William T Evanochko
    Center for NMR Research and Development and the Department of Medicine, Division of Cardiovascular Disease, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Heart Lung Transplant 21:522-9. 2002
    ..If transient ischemia is invoked through the (31)P magnetic resonance spectroscopy (MRS) stress test, monitoring of such an event should be achievable and thus implicating possible ischemic involvement...
  67. ncbi Sublethal actions of copper in abalone (Haliotis rufescens) as characterized by in vivo 31P NMR
    Mark R Viant
    Department of Environmental Toxicology, University of California, Davis, CA 95616, USA
    Aquat Toxicol 57:139-51. 2002
    ..In conclusion, abalone acutely exposed to copper pollution may develop asphyxial hypoxia. Since their survival is dependent on adherence to rock surfaces, such a reduction of muscle function could ultimately prove fatal...
  68. ncbi Oxygen supply and oxidative phosphorylation limitation in rat myocardium in situ
    U Kreutzer
    Department of Biological Chemistry, University of California, Davis, California 95616-8635, USA
    Am J Physiol Heart Circ Physiol 280:H2030-7. 2001
    ..Intracellular O2 supply does not limit MVO2, and the role of ADP in regulating respiration in rat myocardium in vivo remains an open question...
  69. ncbi Diazoxide-induced cardioprotection requires signaling through a redox-sensitive mechanism
    R A Forbes
    Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC, USA
    Circ Res 88:802-9. 2001
    ..These data suggest that the cardioprotective actions of diazoxide are mediated by generation of a pro-oxidant environment...
  70. ncbi Metabolic costs of force generation for constant-frequency and catchlike-inducing electrical stimulation in human tibialis anterior muscle
    Aivaras Ratkevicius
    NMR Center, Department of Medical Biochemistry and Genetics A, Panum Institute, University of Copenhagen, Blegdamsveg 3, DK 2200 Copenhagen N, Denmark
    Muscle Nerve 25:419-26. 2002
    ....
  71. ncbi High-energy phosphate metabolism in the exercising muscle of patients with peripheral arterial disease
    M Schocke
    Department of Radiology, Innsbruck Medical University, Innsbruck, Austria michael
    Vasa 37:199-210. 2008
    ..This review summarizes the results of 31p MRS studies investigating the high-energy phosphate metabolism during ischemic exercise in healthy humans and during ramp or incremental exercise in PAD patients...
  72. ncbi Phosphorous metabolites and steady-state energetics of transformed fibroblasts during three-dimensional growth
    Leoni A Kunz-Schughart
    Langham Resource, Bioscience Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA
    Am J Physiol Cell Physiol 283:C1287-97. 2002
    ....
  73. ncbi Absolute concentrations of high-energy phosphate metabolites in normal, hypertrophied, and failing human myocardium measured noninvasively with (31)P-SLOOP magnetic resonance spectroscopy
    Meinrad Beer
    Institut für Röntgendiagnostik, Wurzburg, Germany
    J Am Coll Cardiol 40:1267-74. 2002
    ..The purpose of the present study was to measure absolute concentrations of phosphocreatine (PCr) and adenosine triphosphate (ATP) in normal, hypertrophied, and failing human heart...
  74. ncbi Dynamics of intramuscular 31P-MRS P(i) peak splitting and the slow components of PCr and O2 uptake during exercise
    H B Rossiter
    Department of Physiology, St George s Hospital Medical School, Tooting, London SW17 0RE, United Kingdom
    J Appl Physiol 93:2059-69. 2002
    ....
  75. ncbi Oxygen regulation and limitation to cellular respiration in mouse skeletal muscle in vivo
    David J Marcinek
    Department of Radiology, Box 357115, University of Washington, 1959 NE Pacific Avenue, Seattle, WA 98195 7115, USA
    Am J Physiol Heart Circ Physiol 285:H1900-8. 2003
    ..Therefore, we reject a regulatory role for oxygen in cellular respiration and conclude that oxygen acts as a simple substrate for respiration under physiological conditions...
  76. ncbi 31P-MRS characterization of sprint and endurance trained athletes
    L Johansen
    Team Danmark Testcenter, Institute of Sports Science and Clinical Biomechanics, University of Southern Denmark, Main Campus Odense University, Campusvej 55, 5230 Odense M, Denmark
    Int J Sports Med 24:183-9. 2003
    ....
  77. ncbi Decreasing ratios of phosphocreatine to beta-ATP correlates to progressive acute rejection in a concordant mouse heart to rat xenotransplantation model
    D J Lukes
    Department of Transplantation and Liver Surgery, Sahlgrenska University Hospital, , Sweden
    Scand J Immunol 53:171-5. 2001
    ..01). Further studies are indicated to establish the potential of (31)P MRS in immunosuppressed recipients of vascularized xenotransplants with prolonged graft survival...
  78. ncbi Preservation of rat skeletal muscle energy metabolism by illumination
    Ann Lindgård
    Department of Surgery and Plastic Surgery, Bioenergetics Group, Wallenberg Laboratory, Sahlgrenska University Hospital, Götenborg University, S 143 45 Götenborg, Sweden
    Life Sci 72:2649-58. 2003
    ..Illumination with SOE at 634 nm improved the preservation potential, in terms of a positive effect on the energy status of the muscle cell...
  79. ncbi A quantitative study of bioenergetics in skeletal muscle lacking utrophin and dystrophin
    M A Cole
    MRC Biochemical and Clinical Magnetic Resonance Unit, Department of Biochemistry, South Parks Road, Oxford OX1 3QU, UK
    Neuromuscul Disord 12:247-57. 2002
    ..The data indicate that the severe abnormalities which are present in the absence of utrophin and dystrophin leave basic muscle energetics intact and appear confined to processes involving the sarcolemma...
  80. ncbi Regulation of murine myocardial energy metabolism during adrenergic stress studied by in vivo 31P NMR spectroscopy
    A V Naumova
    Department of Radiology, Magnetic Resonance Research Division, The Johns Hopkins University School of Medicine, 217 Traylor Building, 720 Rutland Avenue, Baltimore, MD 21205, USA
    Am J Physiol Heart Circ Physiol 285:H1976-9. 2003
    ....
  81. ncbi Decreased high-energy phosphate ratios in the myocardium of men with diabetes mellitus type I
    Bernhard Metzler
    Division of Cardiology, University Hospital Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
    J Cardiovasc Magn Reson 4:493-502. 2002
    ..Myocardial high-energy phosphates have been shown to be reduced by ischemia, and alterations of the cardiac metabolism are the primary consequence of myocardial ischemia...
  82. ncbi Relationship between cerebral interstitial levels of amino acids and phosphorylation potential during secondary energy failure in hypoxic-ischemic newborn piglets
    Takashi Kusaka
    Maternal and Perinatal Center, Kagawa Medical University, Mikicho 1750 1, Kitagun, Kagawa 761 0793, Japan
    Pediatr Res 55:273-9. 2004
    ..The cerebral energy state depended on the time course of changes in excitatory amino acids, suggesting that amino acids play distinct roles during the early and delayed phases of injury...
  83. ncbi Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia
    Stefan Smesny
    Department of Psychiatry, Friedrich Schiller University Jena, Philosophenweg 3, D 07743 Jena, Germany
    Neuroimage 35:729-37. 2007
    ..Results support the notion of disturbed phospholipid turnover in schizophrenia, probably unrelated to prior pharmacological treatment, and associated with increased energy demand...
  84. ncbi Tannin structural elucidation and quantitative ³¹P NMR analysis. 1. Model compounds
    Federica Melone
    Department of Chemical Sciences and Technologies, University of Rome Tor Vergata, Via della Ricerca Scientifica, 00133 Rome, Italy
    J Agric Food Chem 61:9307-15. 2013
    ....
  85. ncbi Determination of glucan phosphorylation using heteronuclear 1H, 13C double and 1H, 13C, 31P triple-resonance NMR spectra
    Peter Schmieder
    Leibniz Institut fur Molekulare Pharmakologie FMP, Robert Rossle Str 10, D 13125, Berlin, Germany
    Magn Reson Chem 51:655-61. 2013
    ....
  86. ncbi Altered relative concentrations of high-energy phosphates in patients with uraemic cardiomyopathy measured by magnetic resonance spectroscopy
    Rajan K Patel
    Renal Research Group, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK
    Nephrol Dial Transplant 27:2446-51. 2012
    ..We also assessed associations of HEP levels with abnormalities of uraemic cardiomyopathy...
  87. ncbi Improve the selectively refocused INEPT pulse sequence for detecting phosphomonoesters and phosphodiesters
    Xi an Mao
    Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA
    Magn Reson Med 68:332-8. 2012
    ....
  88. pmc Pathogenic forms of tau inhibit kinesin-dependent axonal transport through a mechanism involving activation of axonal phosphotransferases
    Nicholas M Kanaan
    Department of Cell and Molecular Biology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Neurosci 31:9858-68. 2011
    ..Results from these studies reveal a novel role for tau in modulating axonal phosphotransferases and provide a molecular basis for a toxic gain-of-function associated with pathogenic forms of tau...
  89. ncbi ³¹P-MRS studies of melanoma xenografts with different metastatic potential
    Lin Z Li
    Department of Radiology, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA
    Adv Exp Med Biol 701:69-73. 2011
    ..The phosphomonoester (PME)/βNTP was higher in the more metastatic C8161 tumors (n=4) than in the less metastatic A375P tumors (n=4) (p < 0.1). No significant difference between the pHi of C8161 and A375P was observed...
  90. ncbi Eli Lilly lecture. The subunits of pituitary thyrotropin--their relationship to other glycoprotein hormones
    J G Pierce
    Endocrinology 89:1331-44. 1971
  91. ncbi 31P NMR of phospholipid metabolites in prostate cancer and benign prostatic hyperplasia
    Richard A Komoroski
    Center for Imaging Research and Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45267 0583, USA
    Magn Reson Med 65:911-3. 2011
    ..The high level of phosphoethanolamine+glycerophosphoethanolamine relative to phosphocholine+glycerophosphocholine suggests that the former may be significant contributors to the "total choline" resonance observed by (1)H MRSI in vivo...
  92. pmc The structural gene for deoxyribonucleic acid polymerase in bacteriophages T4 and T5
    A de Waard
    Proc Natl Acad Sci U S A 54:1241-8. 1965
  93. ncbi RNA phosphodiester backbone dynamics of a perdeuterated cUUCGg tetraloop RNA from phosphorus-31 NMR relaxation analysis
    Jörg Rinnenthal
    Institute for Organic Chemistry and Chemical Biology, Center for Biomolecular Magnetic Resonance, Johann Wolfgang Goethe University, Max von Laue Strasse 7, Frankfurt Main, Germany
    J Biomol NMR 45:143-55. 2009
    ..Nucleic Acids Res 36:1928-1940, 2008). Furthermore, the dynamics of the individual phosphate groups seem to be correlated to the 5' neighbouring nucleobases...
  94. ncbi Genotoxicity of environmentally relevant concentrations of water-soluble oil components in cod (Gadus morhua)
    Tor F Holth
    Norwegian Institute for Water Research NIVA, CIENS, Gaustadalleen 21, NO 0349 Oslo, Norway
    Environ Sci Technol 43:3329-34. 2009
    ..The quantification of PAH metabolites in bile and hepatic DNA adduct formation appear to be suitable for environmental monitoring of chronic oil pollution...
  95. ncbi High-energy phosphates in the frontal lobe correlate with Wisconsin Card Sort Test performance in controls, not in schizophrenics: a 31phosphorus magnetic resonance spectroscopic and neuropsychological investigation
    H P Volz
    Department of Psychiatry, University of Jena, Germany
    Schizophr Res 31:37-47. 1998
    ..This association was not found in schizophrenics, possibly due to the influence of neuroleptic medication or the disease process per se...
  96. ncbi Influence of the mode of insertion of SIV peptides into membranes on the structure of model membrane as studied by 31P NMR
    A Schanck
    Unité de Chimie Physique Moléculaire et de Cristallographie, Universite Catholique de Louvain, Louvain la Neuve, Belgium
    Biochem Biophys Res Commun 250:12-4. 1998
    ..This study reinforces the correlation between fusogenic activity, induction of structures not organized in extended bilayers, and calculated mode of insertion of peptides into lipid layers...
  97. pmc Evaluation of the effects of photodynamic therapy with phosphorus 31 magnetic resonance spectroscopy
    M Nishiwaki
    Department of Microbiology and Immunology, Hamamatsu University School of Medicine, Handa cho Hamamatsu, Japan
    Br J Cancer 80:133-41. 1999
    ..0 when macroscopic recurrence occurred, while it stayed under 1.0 in complete response. This finding suggests that the recurrence of HeLa cell tumours can be detected by the PME/Pi ratio...
  98. ncbi Introduction to in vivo 31P magnetic resonance spectroscopy of (human) skeletal muscle
    A Heerschap
    Department of Radiology, Faculty of Medical Sciences, University of Nijmegen, The Netherlands
    Proc Nutr Soc 58:861-70. 1999
    ....
  99. ncbi Investigation of hepatic gluconeogenesis pathway in non-diabetic Asian Indians with non-alcoholic fatty liver disease using in vivo ((31)P) phosphorus magnetic resonance spectroscopy
    Rajeev Sharma
    Department of Internal Medicine, All India Institute of Medical Sciences, New Delhi, India
    Atherosclerosis 203:291-7. 2009
    ....
  100. ncbi (31)P solid-state MAS-NMR spectroscopy of the compounds that form in phosphate-bonded dental casting investment materials during setting
    Sheelagh N Scrimgeour
    Dental School, University of Dundee, Dundee, UK
    Dent Mater 23:934-43. 2007
    ..To determine whether they differ in material originating at the center of the mix from material that adheres to the mixing bowl wall...
  101. ncbi Synthesis of retinal ganglion cell phospholipids is under control of an endogenous circadian clock: daily variations in phospholipid-synthesizing enzyme activities
    E Garbarino-Pico
    CIQUIBIC CONICET Departamento de Química Biológica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Cordoba, Argentina
    J Neurosci Res 76:642-52. 2004
    ..The results demonstrate that chicken RGCs contain circadian oscillators capable of generating metabolic oscillations in the biosynthesis of phospholipids autonomously...

Research Grants42

  1. Phosphorus MRI of the Lower Extremeties in Diabetics
    ROBERT GREENMAN; Fiscal Year: 2003
    ..abstract_text> ..
  2. The Effect of a Probiotic on Hepatic Steatosis
    Steven Solga; Fiscal Year: 2004
    ..If the efficacy of probiotics is established one type of chronic liver disease, the possibility that similar biological therapies might benefit other chronic inflammatory states would merit further evaluation. ..
  3. Metabolic MRI of Diabetic Lower Extremity Disease
    Robert L Greenman; Fiscal Year: 2010
    ....
  4. BRAINS Morphology and Image Analysis
    Vincent Magnotta; Fiscal Year: 2009
    ....
  5. Feasibility of Rehabilitation Robots and fMRI in Stroke
    A Tzika; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  6. Restriction Endonuclease Structure and Function
    CYNTHIA DUPUREUR; Fiscal Year: 2005
    ....
  7. Regulation of Neuronal Nicotinic Receptors
    Lynn Wecker; Fiscal Year: 2005
    ....
  8. FUNCTIONAL OPTICAL IMAGING OF BRAIN INJURY (fNIRI)
    Britton Chance; Fiscal Year: 2005
    ..These projects represent logical continuations of current activities into new and related researches. ..
  9. High-Res Multishot DTI by Real-Time Navigation
    Eun Kee Jeong; Fiscal Year: 2006
    ..abstract_text> ..
  10. 13th International Congress of Radiation Research
    Mark Dewhirst; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  11. IMP Dehydrogenase and the Hydra of Cancer Chemotherapy
    GEORGE MARKHAM; Fiscal Year: 2008
    ..These results will reveal the inner working of an essential enzyme and whether there is promise for enhancing clinical efficacy through combinations of known drugs or the discovery of novel subdomain ligands. ..
  12. Image-Guided Pro-Drug/Enzyme Therapy
    Zaver Bhujwalla; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  13. Applications of Field-Cycling NMR to Studies of Biomolecules
    Alfred Redfield; Fiscal Year: 2008
    ..We will obtain new information about physical arrangements in these systems, and especially about dynamics of small molecules (substrates and inhibitors) weakly bound to enzymes. ..
  14. High Resolution DTI Using 3D Single-Shot Acquisition
    Eun Kee Jeong; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  15. Brain Phospholipid Composition in Schizophrenia
    Richard Komoroski; Fiscal Year: 2004
    ..It will also potentially provide support and clarification for several aspects of the membrane hypothesis of schizophrenia. ..
  16. BREAST CANCER HYPOXIA ASSESSED BY NITRIC OXIDE
    Britton Chance; Fiscal Year: 2002
    ..If ourintended goals of demonstrating feasibility are achieved, then application for support through regular RO1channels would appear to be justified. ..
  17. PURCHASE OF A MALDI-TOF MASS SPECTROMETER
    Christine Chow; Fiscal Year: 2002
    ..The CIF provides Ph.D.-level expertise in mass spectral techniques, and several in-house experts on mass spectrometry and MALDI-TOF will play key advisory roles. ..
  18. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2002
    ..abstract_text> ..
  19. SOLID STATE NMR STUDIES OF DNA AND RNA DYNAMICS
    Gary Drobny; Fiscal Year: 2002
    ..6 Tesla by completing construction of a multi-resonant CPMAS probe, thus aiding in the completion of specific goals 1-4; 5) Synthesize all isotopically labeled DNA and RNA phosphoramidites required to achieve specific goals 1-4. ..
  20. MULTIDICIPLINARY FUNCTIONAL IMAGING OF CANCER
    Zaver Bhujwalla; Fiscal Year: 2002
    ..abstract_text> ..
  21. INTERFACIAL ACTIVATION OF WATER SOLUBLE PHOSPHOLIPASES
    Mary Roberts; Fiscal Year: 2003
    ..abstract_text> ..
  22. A Study of Site-Specifically Modified RNAs
    Christine Chow; Fiscal Year: 2006
    ..abstract_text> ..
  23. Sleep, Circadian Rhythms and Dementing Illnesses
    David Harper; Fiscal Year: 2007
    ..abstract_text> ..
  24. RESPIRATION AND GLYCOLYSIS--INTEGRATION IN ACTIVE MUSCLE
    Kevin Conley; Fiscal Year: 2002
    ..g., diabetes. An understanding of the integration of metabolism in healthy tissue is the first step to understanding how failure of integration limits function in diseased muscle. ..
  25. FcR Mutations in Kawasaki Disease
    Michael Portman; Fiscal Year: 2008
    ....
  26. UW Stipends for Training Aspiring Researchers (STAR)
    Michael Portman; Fiscal Year: 2008
    ..increasing the numbers of underrepresented minority investigators involved in heart, lung, blood, and sleep disorder research. ..
  27. ENZYMATIC MECHANISMS OF SULFUR NUCLEOSIDE METABOLISM
    GEORGE MARKHAM; Fiscal Year: 2008
    ..These studies will unmask why nature conserves use of a pyruvoyl cofactor for this metabolic function instead of adopting the common pyridoxal cofactor. ..
  28. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2002
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  29. Mitochondrial Dysfunction in Aged Muscle
    David J Marcinek; Fiscal Year: 2010
    ..2) Our long-term goal is the development of non- invasive methods to diagnose mitochondrial dysfunction and follow the progress of interventions meant to reverse disability in the elderly. ..
  30. A Non-invasive Single-trial In-vivo Neuroimaging System
    Paul Sajda; Fiscal Year: 2007
    ..3.Demonstrate that stEEG/tMRI activations maps yield new information for discriminating young and old adult populations, as compared to traditional efMRI and P3 and ERN ERP analysis. ..
  31. Depression and Brain Metabolism
    Dan Iosifescu; Fiscal Year: 2007
    ..The development of a larger scale R01 project investigating the role of brain energy metabolism in a population of treatment-resistant subjects with MDD will be started during the last two years of the award period. ..
  32. FUNCTIONAL MRI MAPPING OF HUMAN THALAMOCORTICAL NETWORKS
    Wei Chen; Fiscal Year: 2003
    ..This is vital to the understanding of human brain functions involving both sensory perception and higher cognitive processes at physiological and pathological conditions. ..
  33. Images of Quantified Hypoxic Stress in Muscle
    Britton Chance; Fiscal Year: 2005
    ..Our especial goals are improving geriatric performance and detecting mitochondrial disease. See Appendix A for Glossary. ..
  34. PROBING FAST NEURONAL INTERACTION USING FUNCTIONAL MRI
    Wei Chen; Fiscal Year: 2005
    ....
  35. Imaging Lymphatic Clearance in Tumor Metastasis
    Zaver Bhujwalla; Fiscal Year: 2003
    ..abstract_text> ..
  36. Myoglobin as an indicator of hpoxia tolerance
    STEPHEN KINSEY; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable] [unreadable]..
  37. Triostat in Children During CPB
    Michael Portman; Fiscal Year: 2007
    ..unreadable]..
  38. DYNAMIC STUDY OF HUMAN BRAIN ACTIVITY WITH FMRI AND FMRS
    Wei Chen; Fiscal Year: 2003
    ..abstract_text> ..
  39. 2 & 3D Imaging of Contrast Agents in Animal Models
    Britton Chance; Fiscal Year: 2004
    ..abstract_text> ..
  40. COREGISTERED IMAGES OF BREAST TUMORS BY MRI AND OPTICAL
    Britton Chance; Fiscal Year: 2003
    ..Large scale tests are available under other support where a direct comparison with not only MRI but also digital mammography, ultrasound and PET will secure the validation studies. ..
  41. Novel RF Coils for In Vivo MR Applications at High Field
    Wei Chen; Fiscal Year: 2007
    ..abstract_text> ..