iodine isotopes

Summary

Summary: Stable iodine atoms that have the same atomic number as the element iodine, but differ in atomic weight. I-127 is the only naturally occurring stable iodine isotope.

Top Publications

  1. ncbi Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush
    Arianna Del Signore
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    J Neuropathol Exp Neurol 63:138-50. 2004
  2. ncbi Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors
    L M Marubio
    Dept Biotechnologies, Institut Pasteur, 75724 Paris Cedex 15, France
    Eur J Neurosci 17:1329-37. 2003
  3. ncbi Hemokinin-1 has Substance P-like function in U-251 MG astrocytoma cells: a pharmacological and functional study
    Alexandra Berger
    Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Department of Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Neuroimmunol 164:48-56. 2005
  4. ncbi Diazepam affects the nuclear thyroid hormone receptor density and their expression levels in adult rat brain
    Caterina Constantinou
    Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Patras 265 00, Greece
    Neurosci Res 52:269-75. 2005
  5. ncbi Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei
    M G Terenzi
    Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis SC 88040 900, Brazil
    Neuroscience 134:345-54. 2005
  6. ncbi Differential effects of two blockers of small conductance Ca2+-activated K+ channels, apamin and lei-Dab7, on learning and memory in rats
    Bedel Mpari
    Laboratoire de Neurobiologie Integrative et Adaptative, Neurobiologie des Processus Mnésiques, UMR 6149, CNRS Université de Provence, Marseille, France
    J Integr Neurosci 4:381-96. 2005
  7. ncbi Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue
    Ildiko Molnar
    Third Department of Internal Medicine, Kenézy County and Teaching Hospital, Bartók B str 2 26, H 4043, Debrecen, Hungary
    Immunol Lett 80:3-7. 2002
  8. ncbi Nicotinic cholinergic receptors in the rat cerebellum: multiple heteromeric subtypes
    Jill R Turner
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Neurosci 25:9258-65. 2005
  9. ncbi A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    Heather A Halem
    IPSEN Group, Milford, MA 01757, USA
    Neuroendocrinology 81:339-49. 2005
  10. ncbi Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766 1854, USA
    Biochemistry 42:7358-70. 2003

Detail Information

Publications195 found, 100 shown here

  1. ncbi Nicotinic acetylcholine receptor subtypes in the rat sympathetic ganglion: pharmacological characterization, subcellular distribution and effect of pre- and postganglionic nerve crush
    Arianna Del Signore
    Dipartimento di Biologia Cellulare e dello Sviluppo, Universita La Sapienza, Rome, Italy
    J Neuropathol Exp Neurol 63:138-50. 2004
    ..This observation and the lack of any effect of preganglionic nerve crush on the number of nicotinic receptors suggest that the peripheral targets affect the organization of intraganglionic synapses in adult SCG...
  2. ncbi Effects of nicotine in the dopaminergic system of mice lacking the alpha4 subunit of neuronal nicotinic acetylcholine receptors
    L M Marubio
    Dept Biotechnologies, Institut Pasteur, 75724 Paris Cedex 15, France
    Eur J Neurosci 17:1329-37. 2003
    ..Our results indicate that alpha4-containing nAChRs exert a tonic control on striatal basal dopamine release, which is mediated by a heterogeneous population of nAChRs...
  3. ncbi Hemokinin-1 has Substance P-like function in U-251 MG astrocytoma cells: a pharmacological and functional study
    Alexandra Berger
    Princess Margaret Hospital, Ontario Cancer Institute, University Health Network, Department of Immunology, University of Toronto, 610 University Avenue, Toronto, Ontario, Canada M5G 2M9
    J Neuroimmunol 164:48-56. 2005
    ..Moreover, we show TAC4 mRNA expression in gliomas, indicating a possible involvement of HK-1 in glioma biology...
  4. ncbi Diazepam affects the nuclear thyroid hormone receptor density and their expression levels in adult rat brain
    Caterina Constantinou
    Laboratory of Human and Animal Physiology, Department of Biology, University of Patras, Patras 265 00, Greece
    Neurosci Res 52:269-75. 2005
    ..The latest effect occurs in an isoform-specific manner involving specifically the TRalpha2 mRNA levels in adult rat brain...
  5. ncbi Oxytocin-induced excitation of neurones in the rat central and medial amygdaloid nuclei
    M G Terenzi
    Department of Physiological Sciences, Federal University of Santa Catarina, Florianopolis SC 88040 900, Brazil
    Neuroscience 134:345-54. 2005
    ..The relative shift in excitatory responses between these two nuclei may underlie some of the neuroendocrine, behavioral and anxiolytic effects which have been ascribed to oxytocin in the periparturient rat...
  6. ncbi Differential effects of two blockers of small conductance Ca2+-activated K+ channels, apamin and lei-Dab7, on learning and memory in rats
    Bedel Mpari
    Laboratoire de Neurobiologie Integrative et Adaptative, Neurobiologie des Processus Mnésiques, UMR 6149, CNRS Université de Provence, Marseille, France
    J Integr Neurosci 4:381-96. 2005
    ....
  7. ncbi Inhibition of type 2,5'-deiodinase by tumor necrosis factor alpha, interleukin-6 and interferon gamma in human thyroid tissue
    Ildiko Molnar
    Third Department of Internal Medicine, Kenézy County and Teaching Hospital, Bartók B str 2 26, H 4043, Debrecen, Hungary
    Immunol Lett 80:3-7. 2002
    ..It can be suggested that the increased level of these cytokines can be one of the reasons in the induction of the clinical symptoms in nonthyroidal illness associated with low levels of T(3)...
  8. ncbi Nicotinic cholinergic receptors in the rat cerebellum: multiple heteromeric subtypes
    Jill R Turner
    Department of Pharmacology, Georgetown University, Washington, DC 20057, USA
    J Neurosci 25:9258-65. 2005
    ..Among these were several subtypes that have not been encountered previously, including alpha3alpha4beta2 and alpha3alpha4beta4 nAChRs. This diversity suggests that nAChRs play multiple roles in cerebellar physiology...
  9. ncbi A novel growth hormone secretagogue-1a receptor antagonist that blocks ghrelin-induced growth hormone secretion but induces increased body weight gain
    Heather A Halem
    IPSEN Group, Milford, MA 01757, USA
    Neuroendocrinology 81:339-49. 2005
    ....
  10. ncbi Noncompetitive antagonist binding sites in the torpedo nicotinic acetylcholine receptor ion channel. Structure-activity relationship studies using adamantane derivatives
    Hugo R Arias
    Department of Pharmaceutical Sciences, College of Pharmacy, Western University of Health Sciences, Pomona, California 91766 1854, USA
    Biochemistry 42:7358-70. 2003
    ..A plausible location of neutral and charged adamantane derivatives is shown in a model of the resting ion channel...
  11. ncbi Exploring the site of anorectic action of peripherally administered synthetic melanocortin peptide MT-II in rats
    Prashant Trivedi
    Department of Obesity and Metabolic Research, Merck Research Laboratories, P O Box 2000, R80M 213, Rahway, NJ 07065, USA
    Brain Res 977:221-30. 2003
    ....
  12. ncbi Comparative distribution of nicotinic receptor subtypes during development, adulthood and aging: an autoradiographic study in the rat brain
    E Tribollet
    Department of Physiology, University Medical Center, 1, rue Michel Servet, CH 1211 Geneva 4, Switzerland
    Neuroscience 124:405-20. 2004
    ..c) The expression of neuronal nicotinic receptors is unaltered in middle aged animals, suggesting that in the rat these receptors do not play any major role in aging process...
  13. ncbi Dopamine transporter as a marker of neuroprotection in methamphetamine-lesioned mice treated acutely with estradiol
    Myreille D'Astous
    Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, CHUL, and Faculty of Pharmacy, Laval University, Quebec City, Que G1V 4G2, Canada
    Neuroendocrinology 79:296-304. 2004
    ....
  14. ncbi Opioid receptors in fast and slow skeletal muscles of normal and dystrophic mice
    Anthony A L Evans
    Department of Physiology, Medical School, University of Birmingham, Birmingham B15 2TT, UK
    Neurosci Lett 366:339-41. 2004
    ..In the soleus the density was approximately 6.4 times higher and the proportion of labelled fibres approximately 1.5 times higher in the dystrophic mice than the normal mice. The receptors were of the delta-opioid subtype...
  15. ncbi Cortical dopamine D2 receptors in type 1 and 2 alcoholics measured with human whole hemisphere autoradiography
    Erkki Tupala
    Department of Forensic Psychiatry, Niuvanniemi Hospital, University of Kuopio, FIN 70240 Kuopio, Finland
    Synapse 54:129-37. 2004
    ..However, these results especially regarding aging effect must be considered as preliminary due to the different age-range of type 2 alcoholics compared to two other groups...
  16. ncbi Altered depression-related behaviors and functional changes in the dorsal raphe nucleus of serotonin transporter-deficient mice
    Alena Lira
    Division of Developmental Psychobiology, Columbia University, New York, New York 10032, USA
    Biol Psychiatry 54:960-71. 2003
    ..Using mice lacking the SERT (SERT KO), we examined the role of SERT function in anxiety- and depression-related behaviors and serotonergic neuron function...
  17. ncbi Agonist-specific coupling of growth hormone secretagogue receptor type 1a to different intracellular signaling systems. Role of adenosine
    Marcos C Carreira
    Department of Medicine, Research Area, Molecular Endocrinology Laboratory, Complejo Hospitalario Universitario de Santiago CHUS and University of Santiago de Compostela, Santiago de Compostela, Spain
    Neuroendocrinology 79:13-25. 2004
    ..The regulation of the ghrelin-activated earliest signaling pathways by adenosine may have unexpected implications in the GHSR-1a actions...
  18. ncbi Expression and plasticity of galanin systems in cortical neurons, oligodendrocyte progenitors and proliferative zones in normal brain and after spreading depression
    Pei Juan Shen
    Howard Florey Institute of Experimental Physiology and Medicine, Austin and Repatriation Medical Centre, The University of Melbourne, Victoria 3010, Australia
    Eur J Neurosci 18:1362-76. 2003
    ....
  19. ncbi A chemically modified preparation of alpha2-macroglobulin binds beta-amyloid peptide with increased affinity and inhibits Abeta cytotoxicity
    Joseph M Mettenburg
    Department of Pathology, University of California, San Diego, La Jolla, California, USA
    J Neurochem 93:53-62. 2005
    ..We propose that alpha2M-cis-Pt/MA is a novel alternative to Abeta-specific antibodies, for studying the efficacy of Abeta-binding agents in vitro and in vivo...
  20. ncbi Serotonin transporter abnormality in the dorsal motor nucleus of the vagus in Rett syndrome: potential implications for clinical autonomic dysfunction
    David S Paterson
    Department of Pathology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Neuropathol Exp Neurol 64:1018-27. 2005
    ..These data suggest hypotheses concerning 5-HT modulation of vagal function for testing in MeCP2 knockout mice to understand mechanisms underlying autonomic dysfunction in patients with Rett syndrome...
  21. ncbi Cytoplasmic regions adjacent to the M3 and M4 transmembrane segments influence expression and function of alpha7 nicotinic acetylcholine receptors. A study with single amino acid mutants
    Francisco Castelán
    Instituto de Neurociencias de Alicante, Universidad Miguel Hernandez CSIC, Alicante, Spain
    J Neurochem 100:406-15. 2007
    ..These results suggest that the cytoplasmic regions close to M3 and M4 play important structural and functional roles...
  22. ncbi Expression of the alpha7, alpha4 and alpha3 nicotinic receptor subtype in the brain and adrenal medulla of transgenic mice carrying genes coding for human AChE and beta-amyloid
    Malahat Mousavi
    Karolinska Institute, Department of Neurotec, Division of Molecular Neuropharmacology, Karolinska University Hospital Huddinge, Novum 5th floor, S 14186 Stockholm, Sweden
    Int J Dev Neurosci 24:269-73. 2006
    ..The findings may have implications for a better understanding the underlying mechanism for AD-related pathogenesis...
  23. ncbi Identification of a novel non-AT1, non-AT2 angiotensin binding site in the rat brain
    Vardan T Karamyan
    Department of Pharmacology and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS 38677, USA
    Brain Res 1143:83-91. 2007
    ..4.24.15 and/or EC 3.4.24.16. However, some unique characteristics of this non-AT1, non-AT2 binding site suggest that it may be a novel angiotensin binding substance...
  24. ncbi Cocaine- and amphetamine-regulated transcript (CART) peptide specific binding in pheochromocytoma cells PC12
    Lenka Maletinska
    Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Prague, Czech Republic
    Eur J Pharmacol 559:109-14. 2007
    ..It decreased food intake in in vivo feeding experiment on fasted mice in a dose of 1 microg/mouse to the same extent as CART(61-102) in a dose of 0.5 microg/mouse...
  25. ncbi Oxytocin receptors in the nucleus accumbens facilitate "spontaneous" maternal behavior in adult female prairie voles
    D E Olazabal
    Department of Psychiatry and Behavioral Sciences, Center for Behavioral Neuroscience, Yerkes National Primate Research Center, Emory University, 954 Gatewood Road NE, Atlanta, GA 30322, USA
    Neuroscience 141:559-68. 2006
    ..This is the first study to show that the nucleus accumbens is involved in the regulation of "spontaneous" maternal behavior and that oxytocin receptor in this brain region facilitates maternal responses...
  26. ncbi Adolescent maturation of cocaine-sensitive neural mechanisms
    Junran Cao
    Department of Anatomy and Neurobiology, School of Medicine, University of California, Irvine, CA, USA
    Neuropsychopharmacology 32:2279-89. 2007
    ..These findings suggest that impulse activity in DA afferents to ventral CPu is immature in adolescents. In conclusion, the present study showed that cocaine-sensitive neuronal circuits continue to mature during adolescence...
  27. ncbi Unexpected sensitivity of the human alpha7 neuronal nicotinic acetylcholine receptor to aminoglycosides
    Jean Charles Hoda
    Department of Neuroscience, Faculty of Medicine, University of Geneva, Geneva, Switzerland
    Neuroreport 17:65-70. 2006
    ..These data suggest that some of their side effects may be attributable to their interactions with neuronal nicotinic acetylcholine receptors...
  28. ncbi Enhancement of insulin-induced PI3K/Akt/GSK-3beta and ERK signaling by neuronal nicotinic receptor/PKC-alpha/ERK pathway: up-regulation of IRS-1/-2 mRNA and protein in adrenal chromaffin cells
    Takashi Sugano
    Department of Pharmacology, Miyazaki Medical College, University of Miyazaki, Miyazaki, Japan
    J Neurochem 98:20-33. 2006
    ..Thus, stimulation of nAChRs up-regulated expression of IRS-1/IRS-2 via Ca(2+)-dependent sequential activation of cPKC-alpha and ERK, and enhanced insulin-induced PI3K/Akt/GSK-3beta and ERK signaling pathways...
  29. ncbi Synthesis of structurally identical fluorine-18 and iodine isotope labeling compounds for comparative imaging
    Zizhong Li
    Medical Department and Chemistry Department, Brookhaven National Laboratory, Upton, New York 11978, USA
    Bioconjug Chem 14:287-94. 2003
    ..Compounds 1 and 2 should allow us to label biomolecules with F-18 or iodine isotopes and gives structurally identical products, which are expected to have identical biological properties and ..
  30. ncbi Comparison of image quality of different iodine isotopes (I-123, I-124, and I-131)
    Erwann Rault
    MEDISIP, ELIS Department, Ghent University, Ghent, Belgium
    Cancer Biother Radiopharm 22:423-30. 2007
    ..This study aimed to compare the image quality that can be achieved by three iodine isotopes: I-131 and I-123 for single-photon emission computed tomography imaging, and I-124 for positron emission ..
  31. ncbi A physiological systems model for iodine for use in radiation protection
    R W Leggett
    Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, USA
    Radiat Res 174:496-516. 2010
    ..proposed model predicts higher absorbed doses to the thyroid per unit uptake to blood for very short-lived iodine isotopes, similar absorbed doses to thyroid for iodine isotopes with half-life of at least a few hours, and ..
  32. ncbi [Modifying influence of iodine deficiency on radiation damage to the fetus (review)]
    A M Liaginskaia
    State Research Centre Institute of Biophysics, Ministry of Health of Russia, Moscow, 123182 Russia
    Radiats Biol Radioecol 44:162-9. 2004
    It known an oppressing action of radiation, including radioactive iodine isotopes on the reproductive system and fetus development...
  33. ncbi Radiolabelled peptides and low molecular weight proteins in metabolic diseases
    C Aprile
    Occupational Health and Rehabilitation Clinic, S Maugeri Foundation, IRCCS, Nuclear Medicine Unit, 8 v Ferrata, 27100 Pavia, Italy
    Q J Nucl Med 47:321-36. 2003
    ..Many of these radiopharmaceuticals have been labelled with iodine isotopes, however their in vivo application suffer of severe limitations due to rapid release of iodine after ..
  34. ncbi Uncertainties on the committed equivalent dose to the thyroid as a function of age for different iodine isotopes
    P Fritsch
    Laboratoire de Radiotoxicologie, CEA DSV DRR SRCA, BP 12, 91680 Bruyères le Châtel, France
    Radiat Prot Dosimetry 105:247-50. 2003
    ..e. 20-30% at a relative epithelial concentration of 20% and 7-14% at a concentration of 3%. Small variations were observed depending on age...
  35. ncbi Radiotracer-based strategies to image angiogenesis
    R H Haubner
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universitat Munchen, Munich, Germany
    Q J Nucl Med 47:189-99. 2003
    ..Different compounds have been labelled with (18F), (111)In, (99m)Tc, (90)Y and several iodine isotopes. In in vitro assays most of them revealed high alpha(v)beta(3) affinity and selectivity...
  36. ncbi Some aspects of the fetal doses given in ICRP Publication 88
    A W Phipps
    National Radiological Protection Board, Chilton, Didcot, Oxon, OX11 0RQ, UK
    Radiat Prot Dosimetry 105:279-84. 2003
    ..early in pregnancy but important exceptions, for which doses are greatest for intakes later in pregnancy, are iodine isotopes and isotopes of the alkaline earth elements, including strontium...
  37. ncbi Competitive protein adsorption of albumin and immunoglobulin G from human serum onto polymer surfaces
    Maria Holmberg
    Department of Micro and Nanotechnology, Technical University of Denmark, Frederiksborgvej 399, DK 4000 Roskilde, Denmark
    Langmuir 26:938-42. 2010
    ..Albumin and immunoglobulin G (IgG) labeled with two different iodine isotopes have been added to human serum solutions of different concentrations, and adsorption has been performed using ..
  38. ncbi Ratio of complex double strand break damage induced by 125IUdR and 123IUdR correlates with experimental in vitro cell killing effectiveness
    E Pomplun
    Forschungszentrum Jülich GmbH Abteilung Sicherheit und Strahlenschutz D 52425 Jülich, Germany
    Radiat Prot Dosimetry 99:81-2. 2002
    ..The ratio of complex DSBs induced by both iodine isotopes correlates with the differences in cell killing effectiveness reported from in vitro survival experiments.
  39. ncbi [Iodine prophylaxis following nuclear accidents]
    Alicja Jaworska
    Statens strålevern, Postboks 55, 1332 Østerås
    Tidsskr Nor Laegeforen 127:28-30. 2007
    Radioactive iodine isotopes may be released to air to a varying degree during accidents with nuclear reactors...
  40. ncbi Characterization of [(3)H]CHIBA-1001 binding to alpha7 nicotinic acetylcholine receptors in the brain from rat, monkey, and human
    Yuko Tanibuchi
    Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba 260 8670, Japan
    Brain Res 1348:200-8. 2010
    ..In summary, [(3)H]CHIBA-1001 would be a useful radioligand for alpha7 nAChRs in the brains of rodents, non-human primates, and humans...
  41. ncbi Would children be adequately protected by existing intervention levels during a radionuclear emergency?
    Bliss L Tracy
    Radiation Protection Bureau, Health Canada, Ottawa, Canada
    Radiat Prot Dosimetry 142:40-5. 2010
    ..risks in children are to a large degree offset by lower breathing rates and it is only in the case of iodine isotopes that children are more at risk. Ingestion of contaminated food products is more complex...
  42. ncbi Neuronal protection from glucose deprivation via modulation of glucose transport and inhibition of apoptosis: a role for the insulin-like growth factor system
    V C Russo
    Centre for Hormone Research, Murdoch Childrens Research Institute, Royal Children s Hospital, Flemington Road, Parkville 3052, Victoria, Australia
    Brain Res 1009:40-53. 2004
    ..These studies also point to the potential use of IGF-I therapy in prevention or amelioration of hypoglycaemic brain injury...
  43. ncbi Renal metastases from thyroid cancer masquerading as renal angiomyolipoma on ultrasonography
    Mohammed Ahmed
    Department of Medicine, MBC 46, King Faisal Specialist Hospital and Research Center, Riyadh 11211, Saudi Arabia
    J Ultrasound Med 25:1459-64. 2006
  44. ncbi Radioactive iodine in thyroid medicine--how it started in Sweden and some of today's challenges
    Soren Mattsson
    Department of Radiation Physics, Lund University, Malmo University Hospital, SE 20502, Malmo, Sweden
    Acta Oncol 45:1031-6. 2006
    ..The paper describes the start of the clinical use of radioiodine, the various iodine isotopes available, measurement techniques and dosimetry...
  45. pmc Cocaine-mediated supersensitivity of 5-HT2A receptors in hypothalamic paraventricular nucleus is a withdrawal-induced phenomenon
    G A Carrasco
    Department of Pharmacology, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Neuroscience 143:7-13. 2006
    ....
  46. pmc Thyroid cancer in Ukraine after the Chernobyl accident (in the framework of the Ukraine-US Thyroid Project)
    Mykola Tronko
    State Institution V P Komisarenko Institute of Endocrinology and Metabolism, National Academy Medical Sciences Ukraine, Vyshgorodska 69, Kiev 04114, Ukraine
    J Radiol Prot 32:N65-9. 2012
    ..Power Plant, millions of residents of Belarus, Russia, and Ukraine were exposed to large doses of radioactive iodine isotopes, mainly I-131...
  47. ncbi A cohort study of thyroid cancer and other thyroid diseases after the chornobyl accident: thyroid cancer in Ukraine detected during first screening
    Mykola D Tronko
    Institute of Endocrinology and Metabolism, Kyiv, Ukraine
    J Natl Cancer Inst 98:897-903. 2006
    The Chornobyl accident in 1986 exposed thousands of people to radioactive iodine isotopes, particularly (131)I; this exposure was followed by a large increase in thyroid cancer among those exposed as children and adolescents, ..
  48. ncbi In vitro characterization of 6-[18F]fluoro-A-85380, a high-affinity ligand for alpha4beta2* nicotinic acetylcholine receptors
    Daniela Gündisch
    Neuroimaging Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, DHHS, Baltimore, Maryland 21224, USA
    Synapse 55:89-97. 2005
    ..These results suggest that 6-[18F]fluoro-A-85380 is a promising radioligand for in vivo imaging of brain alpha4beta2* nicotinic receptors...
  49. ncbi Speciation of 129I and 127I in seawater and implications for sources and transport pathways in the North Sea
    Xiaolin Hou
    Risø National Laboratory, NUK 202, Technical University of Denmark, DK 4000 Roskilde, Denmark
    Environ Sci Technol 41:5993-9. 2007
    ....
  50. ncbi Decreased dopamine transporter availability in male smokers -- a dual isotope SPECT study
    Yen Kuang Yang
    Department of Psychiatry, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan 70428, Taiwan
    Prog Neuropsychopharmacol Biol Psychiatry 32:274-9. 2008
    ..To delineate the role of tobacco addiction in central pre- and post-synaptic dopaminergic activities, we analyzed the central D2-family receptors, the dopamine transporters (DAT), and degrees of dependence in male smokers...
  51. ncbi Brain SPECT analysis by 3D-SSP and phenotype of Parkinson's disease
    Yasunori Mito
    Department of Neurology, Asahikawa Red Cross Hospital, 1 1, Akebono, Asahikawa, Hokkaido, 070 8530, Japan
    J Neurol Sci 241:67-72. 2006
    ..We therefore investigated the association of phenotypes in untreated PD with brain perfusion on SPECT using three-dimensional stereotactic surface projection (3D-SSP) technique...
  52. pmc Sustained treatment with a 5-HT(2A) receptor agonist causes functional desensitization and reductions in agonist-labeled 5-HT(2A) receptors despite increases in receptor protein levels in rats
    Ju Shi
    Department of Pharmacology and Experimental Therapeutics, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Neuropharmacology 55:687-92. 2008
    ....
  53. ncbi Receptor-mediated transport of LIF across blood-spinal cord barrier is upregulated after spinal cord injury
    Weihong Pan
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Neuroimmunol 174:119-25. 2006
    ..This enhanced transport correlated with increased expression of LIFRalpha shown by immunofluorescent staining and Western blot. Therefore, LIFR at the BBB provides an important target for therapeutic intervention...
  54. pmc Crucial role of alpha4 and alpha6 nicotinic acetylcholine receptor subunits from ventral tegmental area in systemic nicotine self-administration
    S Pons
    Unité Neurobiologie Intégrative des Systèmes Cholinergiques, Institut Pasteur, 75724 Paris Cedex 15, France
    J Neurosci 28:12318-27. 2008
    ....
  55. ncbi Pentylenetetrazole-induced convulsions affect cellular and molecular parameters of the mechanism of action of triiodothyronine in adult rat brain
    Stamatis Bolaris
    Department of Human Reproduction, Helena Venizelou Hospital, 2 Venizelou Sqr, 11521 Athens, Greece
    Neuropharmacology 48:894-902. 2005
    ....
  56. ncbi Morphine alters the selective association between mu-opioid receptors and specific RGS proteins in mouse periaqueductal gray matter
    Javier Garzón
    Neurofarmacologia, Instituto de Neurobiologia Santiago Ramon y Cajal, Consejo Superior de Investigaciones Cientificas, Doctor Arce 37, E 28002 Madrid, Spain
    Neuropharmacology 48:853-68. 2005
    ..The opioid produced no change in the membrane levels of RGS9-2, RGS14, RGSZ1 and RGSZ2. Thus, in PAG synaptosomal membranes, a dynamic and selective link exists between, mu-opioid receptors, Gi/o/z proteins and certain RGS proteins...
  57. ncbi Determination of (129)I and (127)I concentration in soil samples from the Chernobyl 30-km zone by AMS and ICP-MS
    Sarata Kumar Sahoo
    Research Centre for Radiation Protection, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 50:325-32. 2009
    ..These results suggest the obtained data of (129)I to be useful for the reconstruction of the (131)I deposition in the contaminated areas...
  58. ncbi Iodophenyl tagged sphingosine derivatives: synthesis and preliminary biological evaluation
    Wenchao Qu
    Department of Radiology, University of Pennsylvania, 3700 Market Street, Room 305, Philadelphia, PA 19104, United States
    Bioorg Med Chem Lett 19:3382-5. 2009
    ..In vitro enzyme assays indicated that the molecules, 5c-e, are potent inhibitors. Thus, they deserve further evaluation as potential radioactive probes for tumor imaging...
  59. ncbi Interaction of corticosterone and nicotine in regulation of prepulse inhibition in mice
    Nicola Ingram
    Behavioural Neuroscience Laboratory, Mental Health Research Institute, Parkville, Melbourne, Australia
    Neuropharmacology 48:80-92. 2005
    ..In situations of high circulating levels of corticosterone, nicotine may be beneficial to restore disruption of PPI...
  60. ncbi Human H9 cells proliferation is differently controlled by vasoactive intestinal peptide or peptide histidine methionine: implication of a GTP-insensitive form of VPAC1 receptor
    Stephanie Goursaud
    IPBC CNRS UMR 6187 Pôle Biologie Santé, 40 Avenue du Recteur Pineau, 86022 Poitiers, France
    J Neuroimmunol 158:94-105. 2005
    ..These data strongly suggested different mechanisms initiated by VIP and PHM and highlighted the key role of GTP-insensitive binding sites in the control of cell proliferation...
  61. ncbi The role of NGF uptake in selective vulnerability to cell death in ageing sympathetic neurons
    Kliment P Gatzinsky
    Department of Clinical Neuroscience, University of Goteborg, Sahlgrenska University Hospital, 413 45 Goteborg, Sweden
    Eur J Neurosci 20:2848-56. 2004
    ..We conclude that vulnerability to, or protection from, age-related neurodegeneration and neuronal cell death are associated with life-long low, or high, levels of NGF uptake, respectively...
  62. ncbi CART receptor binding in primary cell cultures of the rat nucleus accumbens
    Douglas C Jones
    Division of Neuroscience, Yerkes National Primate Research Center of Emory University, 954 Gatewood Rd NE, Atlanta, Georgia 30329, USA
    Synapse 62:122-7. 2008
    ..This is the first demonstration of CART peptide receptor binding in primary cell cultures of the rat brain...
  63. ncbi Linearity and reversibility of iodide adsorption on sediments from Hanford, Washington under water saturated conditions
    Wooyong Um
    Pacific Northwest National Laboratory, Applied Geology and Geochemistry, Richland, WA 99352, USA
    Water Res 38:2009-16. 2004
    ....
  64. pmc Competition for receptors for immunoglobulin on cytotoxic lymphocytes
    I C MacLennan
    Clin Exp Immunol 10:275-83. 1972
  65. pmc Dynamic analysis of amyloid β-protein in behaving mice reveals opposing changes in ISF versus parenchymal Aβ during age-related plaque formation
    Soyon Hong
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Neurosci 31:15861-9. 2011
    ....
  66. ncbi Nicotinic acetylcholine receptor distribution in Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, and vascular dementia: in vitro binding study using 5-[(125)i]-a-85380
    S L Pimlott
    West of Scotland Radionuclide Dispensary, North Glasgow University Hospitals NHS Trust, Western Infirmary, Glasgow, UK
    Neuropsychopharmacology 29:108-16. 2004
    ....
  67. pmc Serum triiodothyronine: measurements in human serum by radioimmunoassay with corroboration by gas-liquid chromatography
    T Mitsuma
    J Clin Invest 50:2679-88. 1971
    ..The radioimmunoassay for T(3) appears to be sufficiently sensitive, precise, and simple to permit its routine clinical application for this purpose...
  68. ncbi Biokinetics of iodide in man: refinement of current ICRP dosimetry models
    L Johansson
    Radiation Physics Department, Umea University Hospital, Umea, Sweden
    Cancer Biother Radiopharm 18:445-50. 2003
    ..The proposed model is applicable for dose estimations with different uptakes in the thyroid as well as for the situation when the thyroid is blocked, completely or incompletely...
  69. ncbi Speciation of iodine isotopes inside and outside of a contaminant plume at the Savannah River Site
    Kathleen A Schwehr
    Laboratory for Oceanographic and Environmental Research, Department of Marine Sciences, Texas A and M University, OCSB 3029, 200 Seawolf Parkway, Galveston, TX 77553, United States
    Sci Total Environ 497:671-8. 2014
    ..Furthermore, the results confirmed the existence of (129)I not only as I(-), but also as OI and IO3(-) species...
  70. ncbi Dopaminergic mechanisms of target detection - P300 event related potential and striatal dopamine
    Oliver Pogarell
    Department of Psychiatry, Ludwig Maximilian University of Munich, Germany
    Psychiatry Res 194:212-8. 2011
    ..This association might be of relevance for the interpretation of P300 studies in psychiatric disorders...
  71. ncbi The anabolic-androgenic steroid nandrolone induces alterations in the density of serotonergic 5HT1B and 5HT2 receptors in the male rat brain
    A M S Kindlundh
    Department of Pharmaceutical Biosciences, Division of Biological Research on Drug Dependence, Box 591, S 751 24 Uppsala, Sweden
    Neuroscience 119:113-20. 2003
    ..In conclusion, serotonergic 5HT(1B) or 5HT(2) receptors are likely to play important roles in mediating observed emotional states and behavioral changes among AAS abusers...
  72. ncbi Effects of endotoxemia on systemic plasma loss and hematocrit in rats
    A A Van Lambalgen
    Laboratory for Physiology, Free University Amsterdam, The Netherlands
    Microvasc Res 36:291-304. 1988
    ..We conclude that fluid extravasation during endotoxemia is temporary, mainly concerns plasma water, and is compensated by mechanisms like reabsorption and increased lymph flow, resulting in restoration of plasma volume...
  73. ncbi In vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression: early kinetics of radiolabelled FIAU
    R Haubner
    Department of Nuclear Medicine, Technische Universitat Munchen, Munich, Germany
    Eur J Nucl Med 27:283-91. 2000
    ..I*-FIAU, where the asterisk indicates that any of the various radioactive iodine isotopes can be used), can be used as a reporter gene for in vivo monitoring of gene transfer and expression...
  74. ncbi Factors controlling mobility of 127I and 129I species in an acidic groundwater plume at the Savannah River Site
    Shigeyoshi Otosaka
    Laboratory for Oceanographic and Environmental Research, Department of Marine Sciences, Texas A and M University, Building 3029, 200 Seawolf Parkway, Galveston, TX 77553, USA
    Sci Total Environ 409:3857-65. 2011
    ..We concluded that removal of iodine from the groundwater through the formation of high molecular weight organo-iodine species is complicated by the release of other more mobile organo-iodine species in the groundwater...
  75. ncbi Polyiodinated triglyceride lipid emulsions for use as hepatoselective contrast agents in CT: effects of physicochemical properties on biodistribution and imaging profiles
    D A Bakan
    Department of Radiology, University of Michigan, Ann Arbor, USA
    Invest Radiol 35:158-69. 2000
    ..This work assessed the effects of mean particle size, total administered dose, and formulation composition on the in vivo biodistribution and imaging profiles of the ITG-LE in rats...
  76. ncbi Selective capture of iodide from solutions by microrosette-like δ-Bi₂O₃
    Long Liu
    Collaborative Innovation Center for Marine Biomass Fibers, Materials and Textiles of Shandong Province, College of Chemistry, Chemical and Environmental Engineering, and Library of Qingdao University, Qingdao University, Qingdao 266071, China
    ACS Appl Mater Interfaces 6:16082-90. 2014
    Radioactive iodine isotopes that are produced in nuclear power plants and used in medical research institutes could be a serious threat to the health of many people if accidentally released to the environment because the thyroid gland ..
  77. pmc Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain
    Rashid Deane
    Frank P Smith Neurosurgical Research Laboratory, Department of Neurosurgery, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Neurochem 88:813-20. 2004
    ....
  78. ncbi Comparisons of a proposed five-seed assay method with the single-seed and batch assay methods for I-125 seeds in ultrasound-guided prostate implants
    P C Lee
    Alexian Brothers Cancer Care Center, Elk Grove Village, Illinois 60007, USA
    Radiat Oncol Investig 7:374-81. 1999
    ..It will facilitate the compliance of the "10%" recommendation from the AAPM TG40; it will make the "ideally 100%" statement from AAPM TG40 a more realistic and practical QA procedure in seed assaying...
  79. ncbi [Gadolinium in arteriography and interventional radiology: 39 patients]
    A Robert
    Service de Radiologie B, CHU J Minjoz, 25030 Besancon, Cedex, France
    J Radiol 83:1759-63. 2002
    ..To report the experience of using various Gadolinium chelates as contrast media in digital subtraction angiography in patients with relative or absolute contraindications for iodinated contrast agents...
  80. pmc Salivary peptide tyrosine-tyrosine 3-36 modulates ingestive behavior without inducing taste aversion
    Maria D Hurtado
    Departments of Pediatrics and Molecular Genetics and Microbiology, College of Medicine and Department of Neuroscience and Psychiatry, Center for Smell and Taste, University of Florida, Gainesville, Florida 32610, Department of Medical Biotechnology, Udmurt State University, 426034 Izhevsk, Russia, and Garvan Institute of Medical Research, Sydney, New South Wales 2010, Australia
    J Neurosci 33:18368-80. 2013
    ..The discovery of this alternative circuit that regulates ingestive behavior without inducing taste aversion may open the possibility of a therapeutic application of PYY for the treatment of obesity via direct oral application. ..
  81. ncbi [Immunoscintigraphy of anti-type IV collagenase monoclonal antibody in nude mice bearing human lung cancer xenograft]
    Yao Dai
    Institute of Medicinal Biotechnology, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, 100050, PR China
    Ai Zheng 22:1243-8. 2003
    ..The aim of this study was to evaluate the tumor-specific distribution of the anti-type IV collagenase monoclonal antibody (mAb) 3G11 by radioimaging in tumor-bearing nude mice...
  82. pmc Adsorption of heterologous gamma-globulins by chopped guinea-pig lung
    C A King
    Immunology 13:1-8. 1967
  83. pmc Effect of rheumatoid factor on complement-mediated phagocytosis
    F C McDuffie
    J Clin Invest 51:3007-14. 1972
    ..Although the results do not exclude the participation of an IgM RF of higher avidity, present only in the tissues in rheumatoid inflammation, circulating IgM RF probably does not play a potentiating role in rheumatoid inflammation...
  84. ncbi Distribution of dopamine D2-like receptors in the human thalamus: autoradiographic and PET studies
    Richard W Rieck
    Department of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA
    Neuropsychopharmacology 29:362-72. 2004
    ....
  85. ncbi Expression and functional properties of α7 acetylcholine nicotinic receptors are modified in the presence of other receptor subunits
    Manuel Criado
    Instituto de Neurociencias, Universidad Miguel Hernandez CSIC, Alicante, Spain
    J Neurochem 123:504-14. 2012
    ....
  86. ncbi Speciation and migration of (129)I in soil profiles
    Maoyi Luo
    School of Nuclear Science and Technology, Xi an Jiaotong University, Xi an 710049, China
    J Environ Radioact 118:30-9. 2013
    ..Similar partitioning of (129)I and (127)I was observed in the loess profiles, the distribution of iodine isotopes followed an order of organic > leachable > reducible > residue...
  87. ncbi Chronic infusion of amyloid-β peptide and sustained attention altered α7 nicotinic receptor density in the rat brain
    Tania Araujo Viel
    School of Arts, Sciences and Humanities, Universidade de Sao Paulo, Av Arlindo Bettio, 1000, Sao Paulo, SP, 03828 080, Brazil
    Curr Alzheimer Res 9:1210-20. 2012
    ..So, the increase in α7 density in brain areas related to memory might be related to a participation of this receptor in the long-lasting change in synaptic plasticity, which is important to improve and maintain memory consolidation...
  88. ncbi Imaging expression of adenoviral HSV1-tk suicide gene transfer using the nucleoside analogue FIRU
    Dharmin Nanda
    Department of Neurology, Daniel den Hoed Cancer Centre, University Hospital Rotterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 29:939-47. 2002
    ..fialuridine; I*-FIAU), where the asterisk denotes any of the radioactive iodine isotopes that can be used...
  89. ncbi Type I and II positive allosteric modulators differentially modulate agonist-induced up-regulation of α7 nicotinic acetylcholine receptors
    Morten S Thomsen
    Neurobiology Research Unit, University Hospital Copenhagen, Copenhagen, Denmark
    J Neurochem 123:73-83. 2012
    ..These results may have implications for the clinical development of α7 nAChR PAMs...
  90. ncbi Iodine isotopes in precipitation: temporal responses to (129)i emissions from the fukushima nuclear accident
    Sheng Xu
    Scottish Universities Environmental Research Center, East Kilbride, G75 0QF, U K
    Environ Sci Technol 47:10851-9. 2013
    ..129)I results from Denmark suggest an insignificant effect of (129)I released from Fukushima to the (129)I levels in Europe. ..
  91. pmc Α4β2 and α7 nicotinic acetylcholine receptor binding predicts choice preference in two cost benefit decision-making tasks
    I A Mendez
    Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
    Neuroscience 230:121-31. 2013
    ..These data suggest that nAChRs (particularly α4β2) play both unique and common roles in decisions that require consideration of different types of reward costs...
  92. pmc The reaction of glucagon with its receptor: evidence for discrete regions of activity and binding in the glucagon molecule
    M Rodbell
    Proc Natl Acad Sci U S A 68:909-13. 1971
    ....
  93. pmc General methods for the study of cells and serum during the immune response: the response to dinitrophenyl in mice
    N R Klinman
    Clin Exp Immunol 4:473-87. 1969
  94. ncbi Speciation of ¹²⁹I in sea, lake and rain waters
    Jukka Lehto
    Laboratory of Radiochemistry, Department of Chemistry, PO Box 55, FIN 00014 University of Helsinki, Finland
    Sci Total Environ 419:60-7. 2012
    ..In all studied water types the main chemical form of both iodine isotopes was iodide; in sea and lake waters by 92-96% and in rain water by 75-88%...
  95. pmc Role of lymphocyte activation products (LAP) in cell-mediated immunity. I. Preparation and partial purification of guinea-pig LAP
    D C Dumonde
    Clin Exp Immunol 10:25-47. 1972
  96. pmc Binding of rabbit gamma globulin by competent Bacillus subtilis cultures
    R J Erickson
    J Bacteriol 99:125-31. 1969
    ..These findings suggest that the DNA is complexed in a deoxyribonuclease-insensitive form to the surface of the cell and is converted to a single-stranded state prior to transport past the membrane and integration into the chromosome...
  97. pmc Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia
    Sébastien Talbot
    Department of Physiology, Faculty of Medicine, Universite de Montreal, C, P, 6128, Succursale Centre Ville, Montreal, H3C 3J7, Quebec, Canada
    J Neuroinflammation 9:16. 2012
    ..To examine the link between TRPV1 and B(1)R in inflammatory pain, this study aimed to determine the ability of TRPV1 to regulate microglial B(1)R expression in the spinal cord dorsal horn, and the underlying mechanism...
  98. pmc Antigen release from insoluble polymer complexes by lymphocyte cell suspensions
    J L Smith
    Clin Exp Immunol 9:869-77. 1971
  99. ncbi Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-β1-42 uptake into mouse brain
    Takahiro Sugihara
    Department of Biochemistry and Molecular Vascular Biology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Japan
    J Alzheimers Dis 28:709-20. 2012
    ..The results thus suggest the potential of esRAGE in protection against the development of Alzheimer's disease...
  100. pmc Cerebral vascular permeability and cellular infiltration in experimental allergic encephalomyelitis
    S Leibowitz
    Immunology 22:859-69. 1972
  101. pmc Tumor associated antigen with pulmonary neoplasms
    P Lo Gerfo
    Ann Surg 175:495-500. 1972

Research Grants30

  1. PET Radiotracers for Imaging Apoptosis
    Robert Mach; Fiscal Year: 2004
    ..If successful, the research described in this research proposal will provide a PET-based imaging procedure for measuring apoptosis that will be of tremendous value to the PET research community. ..
  2. Molecular Imaging of Responses to Cancer Therapy
    Michael Graham; Fiscal Year: 2003
    ..with the iodine symporter gene as a reporter gene and the possibility of imaging it with a wide variety of iodine isotopes and iodine analogs...
  3. Transport of neurotrophic cytokines after spinal cord injury
    Weihong Pan; Fiscal Year: 2007
    ..Understanding the mechanisms of cytokine transport at this regulatory interface would help in the design of new approaches to treat SCI. ..
  4. Transport of TNFalpha across the BBB
    Weihong Pan; Fiscal Year: 2008
    ..These transporters could be novel drug targets and therefore provide promising therapeutic potential. [unreadable] [unreadable]..
  5. Iron regulation at the CNS vascular barriers and aging
    Rashid Deane; Fiscal Year: 2006
    ..abstract_text> ..
  6. Radiolabeled Probes for Imaging Caspase 3 Activation
    Robert Mach; Fiscal Year: 2008
    ..abstract_text> ..
  7. Radioimmunotherapy of CD20+ Lymphomas & CD45+Leukemias
    JOHN PAGEL; Fiscal Year: 2008
    ..abstract_text> ..
  8. Mechanisms of HIV Transport Across the BBB
    William Banks; Fiscal Year: 2004
    ....
  9. MODULATION OF NEUROTRANSMITTER RELEASE BY CANNABINOIDS
    Andrew Gifford; Fiscal Year: 2002
    ..Furthermore, these experiments will give information on the mode of action of cannabinoid antagonists and could suggest novel therapeutic uses for this new class of compounds. ..
  10. Copper's Role in Brain LRP-mediated Abeta Efflux and Aging
    Rashid Deane; Fiscal Year: 2010
    ..These studies may provide new therapeutic insights on how to lower brain A[unreadable] by controlling its CNS barriers transport in Cu-potentiated neurodegenerative disorders. ..
  11. Neuroreceptor Imaging of Tobacco Smokers
    Julie Staley; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  12. Recombinant LRP fragments production for Alzheimer?s disease treatment
    Rashid Deane; Fiscal Year: 2008
    ..This proposal will evaluate the production process of LRP-II and LRP-IV and their potential as new therapies for AD. [unreadable] [unreadable] [unreadable]..
  13. Dopamine D2 Selective Imaging Agents
    Robert Mach; Fiscal Year: 2008
    ..A secondary goal of this project is to develop an iodine-125 labeled radiotracer for in vitro binding studies of the D2 receptor. ..
  14. Occupational exposures and brain cancer
    Elisabeth Cardis; Fiscal Year: 2010
    ..Further analyses of possible interactions between EMF and specific chemicals will also be conducted. ..
  15. Cognition, Tobacco Smoke and Nicotinic Receptor Occupancy
    Julie Staley; Fiscal Year: 2007
    ..In addition they will provide critical information about the interaction of nicotine with p2-nAChR and the relationship to improvements in cognitive performance. [unreadable] [unreadable] [unreadable]..
  16. Regulation of CART Expression in Rat Nucleus Accumbens
    Douglas Jones; Fiscal Year: 2007
    ..abstract_text> ..
  17. OUTER MEMBRANE CYTOCHROMES--TOPOLOGY AND FUNCTION
    Charles Myers; Fiscal Year: 2002
    ..They will also contribute to environmental health by expanding our knowledge on the mechanisms by which manganese, iron, and various heavy metals are mobilized into water supplies. ..
  18. PET Imaging of Breast Cancer via Sigma-2 Receptors
    Robert Mach; Fiscal Year: 2006
    ..abstract_text> ..
  19. PET AND SPECT IMAGING IN ALCOHOLIC SMOKERS
    Julie Staley; Fiscal Year: 2003
    ..abstract_text> ..
  20. DEVELOPMENT OF D3 ANTAGONISTS TO TREAT COCAINE ADDICTION
    Robert Mach; Fiscal Year: 2002
    ..In addition, this research will result in the development of radiolabeled probes for studying both the function of D3 receptors in the CNS and the alteration in D3 receptor density thatoccurs as a consequence of cocaine abuse. ..
  21. PTS1 Regulation of Brain Met Enk Levels in Alcoholism
    William Banks; Fiscal Year: 2004
    ..abstract_text> ..
  22. The Role of p75 Receptor in Tetanus Toxin Transport
    Rafal Butowt; Fiscal Year: 2005
    ..1992; Schneider et al., 2000; Schiavo et al., 2000; Bordet et al., 2001; Kissa et al., 2002). ..
  23. Analysis of Kinesins Mediating Neurotrophin Transport
    Rafal Butowt; Fiscal Year: 2006
    ..abstract_text> ..
  24. Dopamine D3 Receptor Imaging Agents for PET and SPECT
    Robert Mach; Fiscal Year: 2006
    ..A secondary goal of this project is to develop an iodine-125 labeled radiotracer for in vitro binding studies of the D3 receptor. ..
  25. Prion Transport Across the Blood-Brain Barrier
    William Banks; Fiscal Year: 2009
    ..To cause disease, prions must cross the blood-brain barrier to enter the brain. We will determine how prions cross the BBB. Knowing how prions enter the brain should lead to strategies on how to prevent prion diseases. ..
  26. Human Lung Chromium Toxicity: Role of cytochrome b5
    Charles Myers; Fiscal Year: 2007
    ..They will provide a deeper understanding of the mechanisms underlying Cr(VI) toxicity in human lung, and will lead to new insights on the role of b5 in toxicant activation [unreadable] [unreadable]..
  27. Animal model for inhalant abuse
    Andrew Gifford; Fiscal Year: 2004
    ..Additionally, an animal model for inhalant abuse will aid further exploration of the factors contributing to the predisposition, development and potential treatment of inhalant abuse. ..
  28. PET Studies of Alcohol Distribution and Metabolism
    Andrew Gifford; Fiscal Year: 2005
    ..abstract_text> ..
  29. Vascular and Metabolic Mechanisms in Alzheimer's Disease
    Robert Mach; Fiscal Year: 2009
    ..Through the use of the unique resources and personnel at Washington University Medical Center, we have the opportunity to provide answers to important clinical and mechanistic questions in AD. ..
  30. Opiate Addiction and HIV-1 Induced Release of Cytokines
    William Banks; Fiscal Year: 2006
    ....