carbon radioisotopes

Summary

Summary: Unstable isotopes of carbon that decay or disintegrate emitting radiation. C atoms with atomic weights 10, 11, and 14-16 are radioactive carbon isotopes.

Top Publications

  1. ncbi Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques
    Daniela Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 104:338-44. 2005
  2. ncbi In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
    Alexander Gerhard
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurobiol Dis 21:404-12. 2006
  3. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
  4. ncbi Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
  5. ncbi [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease
    M A Mintun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 67:446-52. 2006
  6. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
  7. ncbi In-vivo measurement of activated microglia in dementia
    A Cagnin
    MRC Cyclotron Unit, Imperial College, Faculty of Medicine, Division of Neuroscience and Psychological Medicince, Hammersmith Hospital, London, UK
    Lancet 358:461-7. 2001
  8. ncbi Forensics: age written in teeth by nuclear tests
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Medical Nobel Institute, 17177 Stockholm, Sweden
    Nature 437:333-4. 2005
  9. ncbi Retrospective birth dating of cells in humans
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Cell 122:133-43. 2005
  10. ncbi Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study
    Alexander Gerhard
    MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK
    Neuroimage 24:591-5. 2005

Detail Information

Publications342 found, 100 shown here

  1. ncbi Therapy strategies for locally advanced adenoid cystic carcinomas using modern radiation therapy techniques
    Daniela Schulz-Ertner
    Department of Radiation Oncology, University of Heidelberg, Heidelberg, Germany
    Cancer 104:338-44. 2005
    ....
  2. ncbi In vivo imaging of microglial activation with [11C](R)-PK11195 PET in idiopathic Parkinson's disease
    Alexander Gerhard
    MRC Clinical Sciences Centre and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurobiol Dis 21:404-12. 2006
    ..The absence of significant longitudinal changes suggests that microglia are activated early in the disease process, and levels then remain relatively static, possibly driving the disease via cytokine release...
  3. pmc Post-mortem correlates of in vivo PiB-PET amyloid imaging in a typical case of Alzheimer's disease
    Milos D Ikonomovic
    Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    Brain 131:1630-45. 2008
    ..The strong direct correlation of in vivo PiB retention with region-matched quantitative analyses of Abeta plaques in the same subject supports the validity of PiB-PET imaging as a method for in vivo evaluation of Abeta plaque burden...
  4. ncbi Amphetamine-induced dopamine release: markedly blunted in cocaine dependence and predictive of the choice to self-administer cocaine
    Diana Martinez
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Am J Psychiatry 164:622-9. 2007
    ..Furthermore, the relationship between this dopamine response and the choice to self-administer cocaine in a laboratory model of relapse was investigated...
  5. ncbi [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease
    M A Mintun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 67:446-52. 2006
    ..The authors used this imaging technique to investigate whether abnormal binding occurs in clinically normal individuals, prior to the development of cognitive changes...
  6. ncbi Depressed dopamine activity in caudate and preliminary evidence of limbic involvement in adults with attention-deficit/hyperactivity disorder
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, Bethesda, MD 20892, USA
    Arch Gen Psychiatry 64:932-40. 2007
    ..There is considerable evidence that brain dopamine is involved in ADHD, but it is unclear whether dopamine activity is enhanced or depressed...
  7. ncbi In-vivo measurement of activated microglia in dementia
    A Cagnin
    MRC Cyclotron Unit, Imperial College, Faculty of Medicine, Division of Neuroscience and Psychological Medicince, Hammersmith Hospital, London, UK
    Lancet 358:461-7. 2001
    ..INTERPRETATION: In-vivo detection of increased [11C](R)-PK11195 binding in Alzheimer-type dementia, including mild and early forms, suggests that microglial activation is an early event in the pathogenesis of the disease...
  8. ncbi Forensics: age written in teeth by nuclear tests
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Medical Nobel Institute, 17177 Stockholm, Sweden
    Nature 437:333-4. 2005
    ..Age is determined to within 1.6 years, whereas the commonly used morphological evaluation of skeletal remains and tooth wear is sensitive to within 5-10 years in adults...
  9. ncbi Retrospective birth dating of cells in humans
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Medical Nobel Institute, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Cell 122:133-43. 2005
    ..Retrospective birth dating is a generally applicable strategy that can be used to measure cell turnover in man under physiological and pathological conditions...
  10. ncbi Evolution of microglial activation in patients after ischemic stroke: a [11C](R)-PK11195 PET study
    Alexander Gerhard
    MRC Clinical Sciences Centre and Department of Neuropathology, Faculty of Medicine, Imperial College, London, UK
    Neuroimage 24:591-5. 2005
    ..Our data suggest that [11C](R)-PK11195 PET can be used to investigate both the primary lesion and remote pathological changes following Wallerian degeneration...
  11. ncbi Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography
    Philip W Miller
    Department of Chemistry, Imperial College London, South Kensington, London, SW7 2AZ, UK
    Angew Chem Int Ed Engl 47:8998-9033. 2008
    ..This Review highlights key aspects of the synthesis of PET radiotracers with the short-lived positron-emitting radionuclides (11)C, (18)F, (15)O, and (13)N, with emphasis on the most recent strategies...
  12. pmc Radiocarbon dating of the human eye lens crystallines reveal proteins without carbon turnover throughout life
    Niels Lynnerup
    Department of Forensic Medicine, University of Copenhagen, Copenhagen, Denmark
    PLoS ONE 3:e1529. 2008
    ..Since the change in concentration is significant even on a yearly basis this allows very accurate dating...
  13. pmc Serotonin transporter binding as a possible predictor of one-year remission in major depressive disorder
    Jeffrey M Miller
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, 1051 Riverside Drive, Unit 42, New York, NY, United States
    J Psychiatr Res 42:1137-44. 2008
    ..We assessed baseline 5-HTT binding as a predictor of one-year remission from a MDE, examining binding in brain regions implicated in the pathophysiology of major depressive disorder (MDD)...
  14. ncbi Lower serotonin transporter binding potential in the human brain during major depressive episodes
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, USA
    Am J Psychiatry 163:52-8. 2006
    ..On the basis of postmortem and imaging studies, the authors hypothesized that subjects with major depressive disorder in a major depressive episode have fewer serotonin transporter sites, compared with healthy subjects...
  15. ncbi Radiolabeled amino acids: basic aspects and clinical applications in oncology
    P L Jager
    Department of Nuclear Medicine, PET Center, University Hospital Groningen, Groningen, The Netherlands
    J Nucl Med 42:432-45. 2001
    ..The general feasibility of amino acid imaging in other tumor types has sufficiently been shown, but more research is required in larger patient series and in well-defined clinical settings...
  16. ncbi Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans
    Martin Brunner
    Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Institute of Medical and Chemical Laboratory Diagnostics, Vienna, Austria
    Clin Pharmacol Ther 78:182-90. 2005
    ....
  17. ncbi Noninvasive imaging of macrophages in rheumatoid synovitis using 11C-(R)-PK11195 and positron emission tomography
    Conny J van der Laken
    VU University Medical Center, Amsterdam, The Netherlands
    Arthritis Rheum 58:3350-5. 2008
    ..We undertook this study to investigate whether rheumatoid synovitis can be visualized by PET using the tracer 11C-(R)-PK11195, which binds to peripheral benzodiazepine receptors (PBRs) on macrophages...
  18. pmc Evaluation of dopamine D₂/₃ specific binding in the cerebellum for the positron emission tomography radiotracer [¹¹C]FLB 457: implications for measuring cortical dopamine release
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:991-7. 2011
    ..Nevertheless, caution is advised when using reference tissue methods that rely solely on the cerebellum signal as an input function to quantify [¹¹C]FLB 457 BP(ND)...
  19. ncbi Use of [11C]choline PET-CT as a noninvasive method for detecting pelvic lymph node status from prostate cancer and relationship with choline kinase expression
    Kaiyumars Contractor
    Department of Surgery and Cancer, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, United Kingdom
    Clin Cancer Res 17:7673-83. 2011
    ..To evaluate the accuracy and biological basis for [(11)C]choline-PET-CT in the nodal staging of high risk localized prostate cancer patients...
  20. pmc Initial evaluation of 11C-DPA-713, a novel TSPO PET ligand, in humans
    Christopher J Endres
    Division of Neuroradiology, Johns Hopkins University, Baltimore, Maryland 21231, USA
    J Nucl Med 50:1276-82. 2009
    ..Here, we report the first examination of (11)C-DPA-713 in human subjects using PET...
  21. ncbi In vivo imaging of neuroinflammation in the rodent brain with [11C]SSR180575, a novel indoleacetamide radioligand of the translocator protein (18 kDa)
    Fabien Chauveau
    Service Hospitalier Frederic Joliot, CEA, DSV, I BM, Orsay, France
    Eur J Nucl Med Mol Imaging 38:509-14. 2011
    ..The indoleacetamide-derived 7-chloro-N,N,5-trimethyl-4-oxo-3-phenyl-3,5-dihydro-4H-pyridazino[4,5-b]indole-1-acetamide, SSR180575, is a selective high-affinity TSPO ligand in human and rodents with neuroprotective effects...
  22. ncbi [11C](R)-PK11195 PET imaging of microglial activation in multiple system atrophy
    A Gerhard
    MRC Clinical Sciences Center and Division of Neuroscience, Faculty of Medicine, Imperial College, London, UK
    Neurology 61:686-9. 2003
    ..Providing an indicator of disease activity, [11C](R)-PK11195 PET can thus be used to characterize the in vivo neuropathology of MSA...
  23. ncbi Significant dissociation of brain and plasma kinetics with antipsychotics
    Johannes Tauscher
    Schizophrenia PET program, Centre for Addiction and Mental Health, University of Toronto, Toronto, Ontario, Canada
    Mol Psychiatry 7:317-21. 2002
    ..Our results question the current reliance on plasma kinetics as the main basis for dosing regimens of antipsychotics. Studies of brain kinetics may provide a sounder basis for determining dosing schedules of psychotropic medications...
  24. ncbi 13C isotope-labeled metabolomes allowing for improved compound annotation and relative quantification in liquid chromatography-mass spectrometry-based metabolomic research
    Patrick Giavalisco
    Max Planck Institut fur Molekulare Pflanzenphysiologie, Am Muhlenberg 1, 14476 Potsdam Golm, Germany
    Anal Chem 81:6546-51. 2009
    ....
  25. ncbi Comparative evaluation of the translocator protein radioligands 11C-DPA-713, 18F-DPA-714, and 11C-PK11195 in a rat model of acute neuroinflammation
    Fabien Chauveau
    CEA, DSV, I2BM, LIME, Orsay, France
    J Nucl Med 50:468-76. 2009
    ....
  26. ncbi Effect of APOE genotype on amyloid plaque load and gray matter volume in Alzheimer disease
    A Drzezga
    Department of Nuclear Medicine, Klinikum rechts der Isar, Technischen Universitat Munchen, Ismaninger Str 22, D 81675 München Munich, Germany
    Neurology 72:1487-94. 2009
    ..To examine the influence of the APOE genotype on levels of beta-amyloid (Abeta) plaque load and atrophy in patients with Alzheimer disease (AD) in vivo...
  27. ncbi Positron emission tomography quantification of [(11)C]-DASB binding to the human serotonin transporter: modeling strategies
    N Ginovart
    PET Center, Center for Addiction and Mental Health, and University of Toronto, Toronto, Ontario, Canada
    J Cereb Blood Flow Metab 21:1342-53. 2001
    ....
  28. ncbi Staging of serotonergic dysfunction in Parkinson's disease: an in vivo 11C-DASB PET study
    Marios Politis
    MRC Clinical Sciences Centre and Centre for Neuroscience, Faculty of Medicine, Hammersmith Hospital, Imperial College London, UK
    Neurobiol Dis 40:216-21. 2010
    ..Our results suggest that progressive non-linear serotonergic dysfunction occurs in PD but it does not determine levels of disability. Additionally, chronic exposure to dopaminergic therapy does not appear to influence SERT binding...
  29. ncbi Novel reference region model reveals increased microglial and reduced vascular binding of 11C-(R)-PK11195 in patients with Alzheimer's disease
    Giampaolo Tomasi
    Department of Information Engineering, University of Padova, Padova, Italy
    J Nucl Med 49:1249-56. 2008
    ....
  30. ncbi Visualising microglial activation in vivo
    Richard B Banati
    Department of Neuropathology, Charing Cross Hospital, Imperial College School of Medicine, and MRC Clinical Sciences Centre PET Neurology, Hammersmith Hospital, London, United Kingdom
    Glia 40:206-17. 2002
    ....
  31. pmc [11C]-DPA-713 and [18F]-DPA-714 as new PET tracers for TSPO: a comparison with [11C]-(R)-PK11195 in a rat model of herpes encephalitis
    Janine Doorduin
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Mol Imaging Biol 11:386-98. 2009
    ..In this study, we evaluated the PET tracers [(11)C]-DPA-713 and [(18)F]-DPA-714 as agents for imaging of activated microglia in a rat model of herpes encephalitis...
  32. pmc Metabolic networks in motion: 13C-based flux analysis
    Uwe Sauer
    Institute of Molecular Systems Biology, ETH Zurich, Switzerland
    Mol Syst Biol 2:62. 2006
    ....
  33. ncbi Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain
    Masanori Ichise
    National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Cereb Blood Flow Metab 23:1096-112. 2003
    ..MRTM2 allowed rapid generation of parametric images with the noise reductions consistent with the simulations. Rapid parametric imaging by MRTM2 should be a useful method for human [11C]DASB positron emission tomography studies...
  34. ncbi Dynamics of fat cell turnover in humans
    Kirsty L Spalding
    Department of Cell and Molecular Biology, Karolinska Institute, SE 171 77 Stockholm, Sweden
    Nature 453:783-7. 2008
    ..The high turnover of adipocytes establishes a new therapeutic target for pharmacological intervention in obesity...
  35. pmc A pilot study to assess the efficacy of tariquidar to inhibit P-glycoprotein at the human blood-brain barrier with (R)-11C-verapamil and PET
    Claudia C Wagner
    Department of Clinical Pharmacology, Medical University of Vienna, Vienna, Austria
    J Nucl Med 50:1954-61. 2009
    ..The aim of this study was to measure P-gp function at the human blood-brain barrier (BBB) after tariquidar administration using PET and the model P-gp substrate (R)-(11)C-verapamil...
  36. pmc Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET
    Claudia Kuntner
    Molecular Medicine, AIT Austrian Institute of Technology GmbH, 2444 Seibersdorf, Austria
    Eur J Nucl Med Mol Imaging 37:942-53. 2010
    ....
  37. ncbi Tumor uptake of radiolabeled acetate reflects the expression of cytosolic acetyl-CoA synthetase: implications for the mechanism of acetate PET
    Yukie Yoshii
    Biomedical Imaging Research Center, University of Fukui, Eiheiji, Fukui 910 1193, Japan
    Nucl Med Biol 36:771-7. 2009
    ..In this study, to elucidate the basic mechanism of tumor acetate uptake, we focused on ACSS2 and investigated the role of ACSS2 in the uptake of radiolabeled acetate in tumor cells...
  38. pmc A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh Medical Center Presbyterian, PET Facility, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Pharmacol Exp Ther 333:533-9. 2010
    ..Nevertheless, these data add to the growing literature that suggests D(2/3) agonist radiotracers are more vulnerable to endogenous competition by dopamine than existing D(2/3) antagonist radiotracers...
  39. ncbi Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study
    Ramin V Parsey
    Department of Psychiatry, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Biol Psychiatry 59:106-13. 2006
    ..We measure 5-HT(1A) in MDD, assess the effects of antidepressant exposure (AE), and examine the role of the C(-1019)G polymorphism...
  40. ncbi Dead wood biomass and turnover time, measured by radiocarbon, along a subalpine elevation gradient
    Lara M Kueppers
    Department of Environmental Science, Policy and Management, Ecosystem Sciences Division, 151 Hilgard Hall, University of California, Berkeley, CA 94720, USA
    Oecologia 141:641-51. 2004
    ..Differences in biomass and decay rates along the elevation gradient suggest that climate warming will lead to a loss of dead wood carbon from subalpine forest...
  41. ncbi Characterization of acetate metabolism in tumor cells in relation to cell proliferation: acetate metabolism in tumor cells
    M Yoshimoto
    Biomedical Imaging Research Center, Fukui Medical University, 23 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui, 910-1193, Japan
    Nucl Med Biol 28:117-22. 2001
    ..This in vitro study suggests that [1-(11)C]acetate is appropriate for estimating the growth activity of tumor cells...
  42. ncbi Millennial-aged organic carbon subsidies to a modern river food web
    Nina Caraco
    Cary Institute of Ecosystem Studies, Millbrook, New York 12545 0129, USA
    Ecology 91:2385-93. 2010
    ..The magnitude of this aged carbon subsidy to river zooplankton suggests that modern river food webs may in some cases be buffered from the limitations set by present-day primary production...
  43. pmc Pharmacokinetics, metabolism and excretion of [(14)C]-lenalidomide following oral administration in healthy male subjects
    Nianhang Chen
    Clinical Pharmacology, Celgene Corporation, 86 Morris Avenue, Summit, NJ 07920, USA
    Cancer Chemother Pharmacol 69:789-97. 2012
    ..Assessment of the absorption, metabolism and excretion of [(14)C]-lenalidomide in healthy male subjects following a single oral dose...
  44. ncbi Noninvasive and quantitative assessment of the function of multidrug resistance-associated protein 1 in the living brain
    Toshimitsu Okamura
    Probe Research Section, Department of Molecular Probe, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba shi, Chiba, Japan
    J Cereb Blood Flow Metab 29:504-11. 2009
    ..Moreover, knockout of Mrp1 gene caused approximately a 90% reduction of the efflux rate, compared with wild-type mice. In conclusion, our method allows noninvasive and quantitative assessment for MRP1 function in the living brain...
  45. pmc Elevated [11C]-D-deprenyl uptake in chronic Whiplash Associated Disorder suggests persistent musculoskeletal inflammation
    Clas Linnman
    Department of Psychology, Uppsala University, Uppsala, Sweden
    PLoS ONE 6:e19182. 2011
    ..The present investigation demonstrates that painful processes in the periphery can be objectively visualized and quantified with PET and that (11)C-D-deprenyl is a promising tracer for these purposes...
  46. pmc Positron emission tomography imaging of dopamine D₂/₃ receptors in the human cortex with [¹¹C]FLB 457: reproducibility studies
    Rajesh Narendran
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Synapse 65:35-40. 2011
    ..These data support the further validation of [¹¹C]FLB 457 as a tool to measure amphetamine-induced dopamine release in the human cortex...
  47. ncbi In vitro and in vivo characterisation of [11C]-DASB: a probe for in vivo measurements of the serotonin transporter by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario M5T 1R8, Canada
    Nucl Med Biol 29:509-15. 2002
    ..Together with previous studies, the present findings indicate that [11C]-DASB is a very useful radiopharmaceutical for probing changes in SERT densities using PET imaging in the living human brain...
  48. ncbi Collagen turnover in the adult femoral mid-shaft: modeled from anthropogenic radiocarbon tracer measurements
    Robert E M Hedges
    Research Laboratory for Archaeology, University of Oxford, Oxford OX1 3QY, UK
    Am J Phys Anthropol 133:808-16. 2007
    ..4) Human femoral bone collagen isotopically reflects an individual's diet over a much longer period of time than 10 years, including a substantial portion of collagen synthesised during adolescence...
  49. ncbi In vivo imaging of peripheral benzodiazepine receptors in mouse lungs: a biomarker of inflammation
    Matthew J Hardwick
    Loyola College, Baltimore, MD, USA
    Mol Imaging 4:432-8. 2005
    ..This study suggests that measuring PBR expression using in vivo imaging techniques may be a useful biomarker to image lung inflammation...
  50. pmc Tariquidar-induced P-glycoprotein inhibition at the rat blood-brain barrier studied with (R)-11C-verapamil and PET
    Jens P Bankstahl
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine, Hannover, Germany
    J Nucl Med 49:1328-35. 2008
    ..To enable a comparison with human PET data, we performed kinetic modeling to estimate the rate constants of radiotracer transport across the rat BBB...
  51. ncbi Positron emission tomography quantification of [11C]-harmine binding to monoamine oxidase-A in the human brain
    Nathalie Ginovart
    PET Centre, Centre for Addiction and Mental Health, Toronto, Canada
    J Cereb Blood Flow Metab 26:330-44. 2006
    ..These results indicate the suitability of using [(11)C]-harmine for quantitative evaluation of MAO-A densities using PET and should enable further studies of potential MAO-A dysregulation in several psychiatric and neurologic illnesses...
  52. ncbi Positron emission tomography imaging of peripheral benzodiazepine receptor binding in human immunodeficiency virus-infected subjects with and without cognitive impairment
    Clayton A Wiley
    Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    J Neurovirol 12:262-71. 2006
    ....
  53. ncbi Mapping of central dopamine synthesis in man, using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Clinical Neuroimaging Team, Molecular Neuroimaging Group, Molecular Imaging Center, National Institute of Radiological Sciences, 4 9 1 Anagawa, Chiba 263 8555, Japan
    Ann Nucl Med 21:355-60. 2007
    ..In the present study, we developed a simple method for calculating an indicator of the dopamine synthesis rate with L-[beta-11C]DOPA on a voxel-by-voxel basis for parametric mapping...
  54. ncbi Frontal and temporal dopamine release during working memory and attention tasks in healthy humans: a positron emission tomography study using the high-affinity dopamine D2 receptor ligand [11C]FLB 457
    Sargo Aalto
    Turku PET Centre, University of Turku, FIN 20014 Turku, Finland
    J Neurosci 25:2471-7. 2005
    ..Our results indicate that regionally specific components of the frontotemporal dopaminergic network are functionally involved in WM performance in humans...
  55. ncbi Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography
    Rolf Toornvliet
    Department of Clinical Pharmacology and Pharmacy, VU University Medical Centre, Amsterdam, The Netherlands
    Clin Pharmacol Ther 79:540-8. 2006
    ..Furthermore, the relationship between BBB P-gp activity and peripheral P-gp activity in CD3-positive leukocytes was investigated. Finally, plasma pharmacokinetics of carbon 11-labeled (R)-verapamil was evaluated...
  56. ncbi Neuropathological imaging: in vivo detection of glial activation as a measure of disease and adaptive change in the brain
    Richard B Banati
    Molecular Neuropsychiatry, Department of Neuropathology, Charing Cross Hospital, Imperial College School of Medicine, London, UK
    Br Med Bull 65:121-31. 2003
    ..Systematic attempts are now undertaken, using positron emission tomography and a ligand with relative selectivity for activated microglia, to develop generic imaging tools for a cellular in vivo neuropathology...
  57. ncbi Positron emission tomography imaging of neuroinflammation
    Annachiara Cagnin
    Department of Neuroscience, University of Padova, Via Giustiniani 5, 35128, Padova, Italy
    Neurotherapeutics 4:443-52. 2007
    ....
  58. ncbi Evaluation of methods for generating parametric (R-[11C]PK11195 binding images
    Alie Schuitemaker
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 27:1603-15. 2007
    ..In pathological conditions with reduced flow rates or large variations in blood volume, the basis function method is preferred because it produces less bias and is more precise...
  59. ncbi Advancement in PET quantification using 3D-OP-OSEM point spread function reconstruction with the HRRT
    Andrea Varrone
    Karolinska Institutet, Department of Clinical Neuroscience, Psychiatry Section and Stockholm Brain Institute, R5 02, Karolinska Hospital, 17176, Stockholm, Sweden
    Eur J Nucl Med Mol Imaging 36:1639-50. 2009
    ..This study assessed the quantitative improvements provided by the implementation of the PSF modelling in the reconstruction of the PET data using the High Resolution Research Tomograph (HRRT)...
  60. ncbi Reference and target region modeling of [11C]-(R)-PK11195 brain studies
    Federico E Turkheimer
    Division of Neuroscience, Department of Clinical Neuroscience, Imperial College London, London, United Kingdom
    J Nucl Med 48:158-67. 2007
    ....
  61. ncbi Effect of P-glycoprotein inhibition on methadone analgesia and brain distribution in the rat
    Monica Rodriguez
    Department of Pharmacology, Faculty of Medicine, University of the Basque Country, Barrio Sarriena s n 48940, Leioa, Vizcaya, Spain
    J Pharm Pharmacol 56:367-74. 2004
    ..P-gp, and hence substrate comedication, plays a critical role in the evolution of the methadone analgesic effect and in its brain uptake, independent of the administration route...
  62. ncbi Microglial imaging with positron emission tomography and atrophy measurements with magnetic resonance imaging in multiple sclerosis: a correlative study
    J Versijpt
    Ghent University Hospital, Ghent, The Netherlands
    Mult Scler 11:127-34. 2005
    ....
  63. ncbi AZD2184: a radioligand for sensitive detection of beta-amyloid deposits
    Allan E Johnson
    Disease Biology, AstraZeneca R and D, Sodertalje, Sweden
    J Neurochem 108:1177-86. 2009
    ..Taken together, the pre-clinical profile of AZD2184 in relation to the reference ligand PIB, suggests that (11)C-labeled AZD2184 is a potential radioligand for PET-visualization of beta-amyloid deposits in the living human brain...
  64. pmc Genetic evidence for the role of GDP-mannose in plant ascorbic acid (vitamin C) biosynthesis
    P L Conklin
    Boyce Thompson Institute for Plant Research and Section of Genetics and Development, Cornell University, Ithaca, NY 14853 1801, USA
    Proc Natl Acad Sci U S A 96:4198-203. 1999
    ....
  65. ncbi Plasma kinetic behavior in hyperlipidemic subjects of a lipidic microemulsion that binds to low density lipoprotein receptors
    R C Maranhao
    Heart Institute of the Medical School Hospital Instituto do Coração do HC FMUSP, Sao Paulo, Brazil
    Lipids 32:627-33. 1997
    ..On the other hand, in four severely hypertriglyceridemic patients, LDE FCR was not significantly different from the controls (0.07 +/- 0.03 h-1). These results suggest that LDE can be a useful device to study lipoprotein metabolism...
  66. ncbi Dopamine release in the human striatum: motor and cognitive tasks revisited
    Julia M Lappin
    Institute of Psychiatry, King s College London, London, UK
    J Cereb Blood Flow Metab 29:554-64. 2009
    ..No additional DA release was observed specific to the cognitive component of either task...
  67. ncbi 11C-acetate PET imaging of prostate cancer
    Nobuyuki Oyama
    Department of Urology, Fukui Medical University, Fukui, Japan
    J Nucl Med 43:181-6. 2002
    ..The uptake of (11)C-acetate in prostate cancer was investigated to determine whether this tracer has potential in tumor identification...
  68. ncbi Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
    V Kaasinen
    Department of Neurology, University of Turku, Finland
    Neurobiol Aging 21:683-8. 2000
    ..Further, the rate of D2/3R decline may be faster in the frontal cortex as compared to the temporal and thalamic regions...
  69. ncbi In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil
    Young Joo Lee
    The Graduate School of Pharmaceutical Sciences, The University of Tokyo, Bunkyo ku, Japan
    J Pharmacol Exp Ther 316:647-53. 2006
    ..61-fold (0.141 versus 0.651 ml/g brain/min, p < 0.05). These results suggest that PET measurement with [(11)C]verapamil can be used for the evaluation of P-gp function at the BBB in the living brain...
  70. ncbi 3-Hydroxybenzo(a)pyrene as a biomarker of dermal exposure to benzo(a)pyrene
    Jean Paul Payan
    Institut National de Recherche et de Securite, Vandoeuvre, France
    Arch Toxicol 83:873-83. 2009
    ..Conversely, BaP was largely lower metabolised as 3-OHBaP during percutaneous absorption by humans, so BaP absorption flux should be overestimated to a lesser extent in humans than in rats...
  71. ncbi Development of a tracer kinetic plasma input model for (R)-[11C]PK11195 brain studies
    Marc A Kropholler
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 25:842-51. 2005
    ..It was concluded that a two-tissue reversible compartment model with K(1)/k(2) fixed to whole cortex value is optimal for analyzing (R)-[(11)C]PK11195 PET brain studies...
  72. ncbi Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo
    Emmanuelle Briard
    Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Med Chem 51:17-30. 2008
    ..11)C] 3 and [ (11)C] 10 are effective for imaging PBR in monkey brain. [ (11)C] 10 especially warrants further evaluation in human subjects...
  73. ncbi Brain serotonin transporter binding in non-depressed patients with Parkinson's disease
    M Guttman
    Human Neurochemical Pathology Laboratory, Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada
    Eur J Neurol 14:523-8. 2007
    ..Further investigation will be required to establish whether SERT binding is more or less decreased in those patients with PD who also have major depressive disorder...
  74. ncbi Lower dopamine transporter binding potential in striatum during depression
    J H Meyer
    PET Imaging Centre, and Mood Division, Centre for Addiction and Mental Health, Department of Psychiatry and University of Toronto, 250 College St, Toronto, Ont. M5T1R8, Canada
    Neuroreport 12:4121-5. 2001
    ..Lower DAT BP itself reduces extracellular clearance of dopamine. Patients who did not decrease their striatal DAT BP failed to compensate for low dopamine and showed greater impairment on dopamine related tests...
  75. ncbi 11C-Acetate PET imaging for renal cell carcinoma
    Nobuyuki Oyama
    Department of Urology, University of Fukui, 23 3 Matsuoka Shimoaizuki, Eiheiji, Fukui 910 1193, Japan
    Eur J Nucl Med Mol Imaging 36:422-7. 2009
    ..In this study, we investigated the effectiveness of positron emission tomography (PET) with (11)C-acetate (AC) for evaluation of renal cell carcinoma...
  76. ncbi Imaging glial cell activation with [11C]-R-PK11195 in patients with AIDS
    Dima A Hammoud
    Department of Radiology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21287 2182, USA
    J Neurovirol 11:346-55. 2005
    ..The findings of this pilot study support a role for glial cell activation in HAD, and that PET with [11C]-R-PK11195 can detect the concomitants of neuronal damage in individuals infected with HIV...
  77. ncbi Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil
    Oliver Langer
    Department of Clinical Pharmacology, Division of Clinical Pharmacokinetics, Medical University of Vienna, Vienna, Austria
    Epilepsia 48:1774-84. 2007
    ..We compared R-[(11)C]verapamil kinetics in homologous brain volumes of interest (VOIs) located ipsilateral and contralateral to the seizure focus...
  78. ncbi [(Methyl)1-(11)c]-acetate metabolism in hepatocellular carcinoma
    Nicolas Salem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Mol Imaging Biol 13:140-51. 2011
    ..In this study, the metabolic fate of [(11)C]Act in HCC was characterized...
  79. pmc In vivo validation of reconstruction-based resolution recovery for human brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 30:381-9. 2010
    ....
  80. ncbi Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat
    Gert Luurtsema
    Department of Nuclear Medicine and PET Research, VU University Medical Centre, P O Box 7057, 1007 MB Amsterdam, The Netherlands
    Nucl Med Biol 32:87-93. 2005
    ..Sixty minutes after injection, unmetabolized (R)-[11C] verapamil was 27% and 48% in the plasma and the brain, respectively...
  81. ncbi Disposition of a low dose of bisphenol a in male and female cynomolgus monkeys
    Hideo Kurebayashi
    Division of Pharmacology, National Institute of Health Sciences, Kamiyoga 1 18 1, Setagaya, Tokyo 158 8501, Japan
    Toxicol Sci 68:32-42. 2002
    ..5%) after oral dose. These results indicate that the intestinal absorption and metabolism of BPA was rapid and extensive, and the major metabolites, glucuronide conjugates of 14C-BPA, were rapidly excreted into urine in monkeys...
  82. ncbi Metabolite profiling of bendamustine in urine of cancer patients after administration of [14C]bendamustine
    Anne Charlotte Dubbelman
    Department of Clinical Pharmacology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Drug Metab Dispos 40:1297-307. 2012
    ..The range of metabolic reactions is generally consistent with those reported for rat urine and bile, suggesting that the overall processes involved in metabolic elimination are qualitatively the same in rats and humans...
  83. pmc Analysis of 14C and 13C in teeth provides precise birth dating and clues to geographical origin
    K Alkass
    Division of Forensic Medicine, Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    Forensic Sci Int 209:34-41. 2011
    ..This strategy can assist police and forensic authorities when attempting to solve unidentified homicide cases and may facilitate the identification work associated with mass disasters...
  84. ncbi Synthesis and evaluation of 2-pyridylbenzothiazole, 2-pyridylbenzoxazole and 2-pyridylbenzofuran derivatives as 11C-PET imaging agents for beta-amyloid plaques
    Britt Marie Swahn
    Department of Medicinal Chemistry, AstraZeneca R and D Sodertalje, Sodertalje, Sweden
    Bioorg Med Chem Lett 20:1976-80. 2010
    ..It is shown that it was possible to increase the signal-to-background ratios compared to PIB 1, as demonstrated by compounds 8 and 21...
  85. ncbi Association between striatal and extrastriatal dopamine D2-receptor binding and social desirability
    Simon Cervenka
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Neuroimage 50:323-8. 2010
    ..Taken together with previous evidence on D2-receptor binding and social behaviour, a role for dopaminergic neurotransmission in regulating displays of dominance vs. submissive behaviour is proposed...
  86. pmc Evaluating dopamine reward pathway in ADHD: clinical implications
    Nora D Volkow
    National Institute on Drug Abuse, 6001 Executive Blvd, Room 5274, MSC 9581, Bethesda, MD 20892, USA
    JAMA 302:1084-91. 2009
    ....
  87. ncbi Repair of skin damage during fractionated irradiation with gamma rays and low-LET carbon ions
    Koichi Ando
    Heavy Ion Radiobiology Research Group, National Institute of Radiological Sciences, Chiba, Japan
    J Radiat Res 47:167-74. 2006
    ....
  88. ncbi Synthesis and application of isocyanates radiolabeled with carbon-11
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Ontario, Canada
    Chemistry 17:259-64. 2011
    ..This is demonstrated by using the method to make [carbonyl-(11) C]-6-hydroxy-[1,1'-biphenyl]-3-yl cyclohexylcarbamate which is a novel radiotracer for PET imaging of fatty acid amide hydrolase...
  89. ncbi Effects of antidepressant drug treatment and psychotherapy on striatal and thalamic dopamine D2/3 receptors in major depressive disorder studied with [11C]raclopride PET
    Jussi Hirvonen
    Department of Psychiatry, University of Turku, Turku, Finland
    J Psychopharmacol 25:1329-36. 2011
    ..The effects of fluoxetine on thalamic dopamine systems need to be further explored...
  90. ncbi Synthesis, in vitro and in vivo evaluation, and radiolabeling of aryl anandamide analogues as candidate radioligands for in vivo imaging of fatty acid amide hydrolase in the brain
    Leonie Wyffels
    Department of Radiopharmacy, Ghent University, Harelbekestraat 72, B 9000 Ghent, Belgium
    J Med Chem 52:4613-22. 2009
    ..They were successfully labeled with 11C in good yields and high radiochemical purity and displayed brain uptake in C57BL/6J mice. Radioligands [11C]-17 and [11C]-18 merit further investigation in vivo...
  91. ncbi Gastric emptying of a liquid nutrient meal in the critically ill: relationship between scintigraphic and carbon breath test measurement
    M J Chapman
    Department of Intensive Care Medicine, Royal Adelaide Hospital, South Australia, Australia
    Gut 60:1336-43. 2011
    ..The aims of this study were to (i) determine the prevalence of delayed GE in unselected, critically ill patients and (ii) evaluate the relationships between GE as measured by scintigraphy and carbon breath test...
  92. ncbi Quantitative analysis of dopamine synthesis in human brain using positron emission tomography with L-[beta-11C]DOPA
    Hiroshi Ito
    Departments of Molecular Neuroimaging, Molecular Imaging Center, National Institute of Radiological Sciences, Chiba, Japan
    Nucl Med Commun 27:723-31. 2006
    ..In the present study, the regional kinetics of L-[beta-C]DOPA in normal human brain and the accuracy of the method for quantifying L-[beta-C]DOPA kinetics, employing reference regions, were investigated...
  93. ncbi Response of Chinese hamster v79 multicellular spheroids exposed to high-energy carbon ions
    A Staab
    Institute of Physiology and Pathophysiology, University of Mainz, D 55099 Mainz, Germany
    Radiat Res 161:219-27. 2004
    ..In summary, the results suggest that carbon ions in the extended Bragg peak are more effective than conventional X rays, particularly under hypoxic conditions...
  94. ncbi Radiosynthesis of the candidate beta-amyloid radioligand [(11)C]AZD2184: Positron emission tomography examination and metabolite analysis in cynomolgus monkeys
    Jan D Andersson
    Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden
    Synapse 64:733-41. 2010
    ..On the basis of the labeling chemistry and the results of the biological evaluation, we conclude that [(11)C]5 should be useful for routine clinical studies...
  95. ncbi Analysis of artificial radiocarbon in different skeletal and dental tissue types to evaluate date of death
    Douglas H Ubelaker
    Department of Anthropology, Smithsonian Institution, NMNH, MRC 112, Washington, DC 20560 0112, USA
    J Forensic Sci 51:484-8. 2006
    ..Within the bone sample analyses, the values of the trabecular bone were higher than those of cortical bone and supported the known placement on the pre-1963 side of the bomb-curve...
  96. ncbi C-11 choline versus F-18 fluorodeoxyglucose for imaging meningiomas: an initial experience
    Giampiero Giovacchini
    Center for Molecular Bioimaging, University of Milano Bicocca, Milan, Italy
    Clin Nucl Med 34:7-10. 2009
    ..The aim of this study was to compare C-11 choline and F-18 fluorodeoxyglucose (F-18 FDG) uptake in meningiomas and relate these findings to the histopathological analysis...
  97. ncbi Direct fixation of [(11)C]-CO(2) by amines: formation of [(11)C-carbonyl]-methylcarbamates
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health and University of Toronto, Toronto, Canada
    Org Biomol Chem 8:428-32. 2010
    ..The usefulness of the method is illustrated by the efficient radiosynthesis of a kappa opioid receptor imaging radiotracer, useful in positron emission tomography (PET)...
  98. ncbi Metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein in young obese and normal-weight patients with polycystic ovary syndrome
    Michelle P Rocha
    Endocrinology Section, Medical School Hospital, University of Sao Paulo, Sao Paulo, Brazil
    Fertil Steril 93:1948-56. 2010
    ..To clarify whether the metabolism of triglyceride-rich lipoproteins and lipid transfer to high-density lipoprotein (HDL) are altered in patients with polycystic ovary syndrome (PCOS)...
  99. ncbi [11C]CURB: Evaluation of a novel radiotracer for imaging fatty acid amide hydrolase by positron emission tomography
    Alan A Wilson
    PET Centre, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
    Nucl Med Biol 38:247-53. 2011
    ..We here determine the suitability of a novel carbon-11-labeled inhibitor of FAAH via ex vivo biodistribution studies in rat brain in conjunction with pharmacological challenges...
  100. ncbi Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents
    Chester A Mathis
    Department of Radiology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Med Chem 46:2740-54. 2003
    ..The encouraging in vitro and in vivo properties of [(11)C]6-OH-BTA-1 support the choice of this derivative for further evaluation in human subject studies of brain Abeta deposition...
  101. ncbi Image-derived input functions for PET brain studies
    Jurgen E M Mourik
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 36:463-71. 2009
    ..To assess the robustness of a previously introduced method to obtain accurate image-derived input functions (IDIF) for three other tracers...

Research Grants70

  1. Biological Predictors of Response to Antidepressants
    Ramin V Parsey; Fiscal Year: 2010
    ..Our overall goal is to reduce the trial and error associated with finding an effective antidepressant by using data from pre-treatment quantification of 5-HT1A receptors and 5-HTT to guide antidepressant treatment selection. ..
  2. Imaging of Serotonin Transporters in Depression
    RAMIN PARSEY; Fiscal Year: 2005
    ..These goals will be met by a combination of didactic I course work and supervision. ..
  3. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2002
    ....
  4. Addiction and the Brain: Are We Hard Wired to Abuse Drugs
    Joanna Fowler; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  5. RADIOTRACER R & D IN NUCLEAR MEDICINE AND NEUROSCIENCES
    Joanna Fowler; Fiscal Year: 2004
    ....
  6. Radiotracer R and D in Nuclear Medicine and Neuroscience
    Yu Shin Ding; Fiscal Year: 2006
    ..abstract_text> ..
  7. Estrogen and the Aging Blood Brain Barrier
    OAK CHI; Fiscal Year: 2002
    ..The information obtained from our study will be crucially important for the clinical application of estrogen therapy for stroke as well as understanding the pathophysiology of age related cerebrovascular changes. ..
  8. PET Behavioral Brain Mapping In Freely Moving Animals
    DANIEL HOLSCHNEIDER; Fiscal Year: 2006
    ..Such knowledge may provide the basis of an improved integration of a functional brain anatomy in the context of mental disorders. ..
  9. PET Imaging of Mesolimbic Dopamine in Heroin Dependence
    Diana Martinez; Fiscal Year: 2007
    ..abstract_text> ..
  10. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2002
    ....
  11. MURINE MODEL OF CAG REPEAT DISEASES
    Roger Albin; Fiscal Year: 2002
    ..These experiments will establish HPRT-CAG mice as important tools for understanding neurodegeneration in CAG repeat diseases and enable accurate preclinical evaluation of interventions for CAG repeat diseases. ..
  12. Evaluating Striatal Function in a Murine HD Model
    Roger Albin; Fiscal Year: 2007
    ..Validation of these methods will provide new and useful behavioral tools for evaluating murine disease models. [unreadable] [unreadable] [unreadable]..
  13. AN IMPLANTABLE BOLUS INFUSION PUMP FOR THE NEUROSCIENCES
    DANIEL HOLSCHNEIDER; Fiscal Year: 2001
    ....
  14. Microinfusion Pump For Animal Functional Brain Mapping
    DANIEL HOLSCHNEIDER; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  15. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2001
    ..Finally, [11C]- and [18F]-labeled polar derivatives of the psychostimulant methcathinone will be synthesized as potential NET markers and their in vitro NET affinities determined as the cloned human NET transporter. ..
  16. The Effects of Cannabis Use/Abuse on In Vivo Dopamine Function
    WILLIAM FRANKLE; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  17. HEART IMAGING AGENTS--STRUCTURAL MECHANISTICS STUDY
    David Raffel; Fiscal Year: 2004
    ..Finally, [11C]- and [18F]-labeled polar derivatives of the psychostimulant methcathinone will be synthesized as potential NET markers and their in vitro NET affinities determined as the cloned human NET transporter. ..
  18. New PET Radiotracers-Monoamine Transporters
    Michael Kilbourn; Fiscal Year: 2003
    ....
  19. The Neuroanatomy of Antipsychotic Drug Action
    WILLIAM FRANKLE; Fiscal Year: 2008
    ..abstract_text> ..
  20. FDG PET-CT in Metastatic Prostate Cancer
    Hossein Jadvar; Fiscal Year: 2010
    ..Rigorous statistical methods will be applied to determine the diagnostic and prognostic performance of FDG PET-CT in this clinical setting. ..
  21. GCPII-Based Brain Imaging Agents
    Martin Pomper; Fiscal Year: 2008
    ..Working with our knowledge of PSMA/GCPII imaging and the recently published crystal structure of PSMA, we intend to pursue new derivatives suitable for imaging GCPII within the central nervous system ..
  22. PET Imaging MDMA Neurotoxicity
    Una McCann; Fiscal Year: 2006
    ..g., dementia, Parkinsonism, depression/anxiety). In addition, the proposed 18FDG studies will address the question of if MDMA exposure leads to altered brain function at the most fundamental level, glucose utilization. ..
  23. New PET radioligand for the serotonin transporter
    Yiyun Huang; Fiscal Year: 2007
    ..Introduction of [18F]AFM would constitute the first PET tracer for the SERT that can be prepared in a central facility and distributed to various sites for clinical imaging purposes. ..
  24. Imaging Serotonergic Transmission in HIV Depression
    Martin Pomper; Fiscal Year: 2006
    ..abstract_text> ..
  25. High End Computing for PET/SPECT
    DEAN WONG; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  26. PSMA-based SPECT Tracers for Prostate Cancer Imaging
    Martin Pomper; Fiscal Year: 2007
    ..unreadable] [unreadable]..
  27. PSMA-based PET Ligands for Prostate Cancer Imaging
    Martin Pomper; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  28. Sleep and Nocturnal Endocrine Function in MDMA User
    Una McCann; Fiscal Year: 2007
    ..Results from the proposed studies will help better define the functional consequences of MDMA exposure in humans, and could shed light on the roles of 5-HT and DA in sleep and nocturnal endocrine function. ..
  29. PSMA-based Gene Reporter-Probe System(RMI)
    Martin Pomper; Fiscal Year: 2008
    ..unreadable] [unreadable]..
  30. IMAGING DOPAMINE/SEROTONIN MECHANISMS IN COCAINE CRAVING
    DEAN WONG; Fiscal Year: 2003
    ..Testing of these hypotheses will provide novel and fundamental answers to craving mechanisms. ..
  31. MECHANISMS OF DOPAMINE & SEROTONIN IN TOURETTE SYNDROME
    DEAN WONG; Fiscal Year: 2003
    ..We propose to carry out experiments using PET to establish a more complete understanding of the neurotransmission in TS. This will also help establish new ationales for improved therapeutics in TS. ..
  32. IMAGING DOPAMINE RELEASE/ENDOCRINE CHANGES IN ALCOHOLISM
    DEAN WONG; Fiscal Year: 2004
    ..If the initial D2 receptor deficits are exacerbated by alcohol abuse one can envision a positive feedback loop hard to break. ..
  33. Probing D2 receptor in vivo
    Dah Ren Hwang; Fiscal Year: 2003
    ..In addition to schizophrenia, this radiotracer will provide a useful tool for characterization of dopamine transmission at the D2 receptor in a variety of other conditions, such as ADHD, Parkinson's disease, and substance abuse. ..
  34. ALCOHOLISM AND ENDOGENOUS OPIOID ACTIVITY
    Gary Wand; Fiscal Year: 2008
    ..Fortype specifications, see instructions onpage 6.) RESEARCH GRANT TABLE OF CONTENTS PageNumbers Face Page 1 Description, ..
  35. INDICES OF BIOTIN NUTRITION
    Donald Mock; Fiscal Year: 2001
    ..4) Whether biotin deficiency of similar severity to that observed either early or late in human gestation causes increased rates of fetal malformation in the mouse. 5) The enzyme(s) responsible for biotin beta-oxidation. ..
  36. LOCALIZATION OF EPILEPTIC FOCI WITH PET IN CHILDREN
    Harry Chugani; Fiscal Year: 2009
    ..abstract_text> ..
  37. CNS METABOLIC CORRELATES OF HIV DEMENTIA BY MRS IMAGING
    Martin Pomper; Fiscal Year: 2001
    ..abstract_text> ..
  38. Development of PET radioligands for cerebral cannabinoid receptor (CB1)
    ANDREW HORTI; Fiscal Year: 2008
    ....
  39. Dedicated High Performance Human Brain/Preclinical PET
    DEAN WONG; Fiscal Year: 2004
    ..abstract_text> ..
  40. Alzheimer's Diagnosis by Real-Time Motion Corrected FMRI
    Clifford Jack; Fiscal Year: 2004
    ..Aim number 4: to assess motion corrected fMRI as a diagnostic test for early Alzheimer's disease. ..
  41. Implementation of [18F] FEOBV for VAChT Imaging with PET
    Robert Koeppe; Fiscal Year: 2004
    ..g. AD). R33 (Year 5): Conclude clinical evaluations in normal control and patient groups. ..
  42. PHYSIOLOGIC STUDIES OF ANGER IN DEPRESSED PATIENTS
    Darin Dougherty; Fiscal Year: 2002
    ..abstract_text> ..
  43. MRI of Acute Vascular Injury and Hemorrhagic Transformation in Ischemic Stroke
    Robert A Knight; Fiscal Year: 2010
    ..e., BBB opening) and both will be functions of the variations in BBB associated proteins and/or brain swelling;and 2) the size of these changes are correlated over time, ROI, and treatment. ..
  44. Quantitation of Tocopherol Metabolism in Humans
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..Particular attention will be directed to the absorption phase. The results are expected to provide information about vitamin E biopotency and eventually improved Dietary Recommendations. ..
  45. Neuronogenesis in the Non-pigmented Retina
    RICHARD NOWAKOWSKI; Fiscal Year: 2008
    ..Such detailed information is important for understanding how the lack of retinal pigment produces abnormalities and for the rationale development of treatments and therapies. ..
  46. Molecular Organization or Renal Organic Anion Transport
    Stephen H Wright; Fiscal Year: 2010
    ..abstract_text> ..
  47. Transporter-Enzyme Interplay Evaluation via Microfluidiic HTS Cell Culture Device
    Leslie Benet; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  48. Quantitation of In Vivo Human Lutein Metabolism
    ANDREW JOSEPH CLIFFORD; Fiscal Year: 2010
    ..Therefore, the purpose of this study is to determine how the human body uses lutein and other related compounds. ..
  49. Micro Computerized Tomography Imaging System
    PETER CONTI; Fiscal Year: 2004
    ....
  50. PERITONEAL DELIVERY OF ANTINEOPLASTIC MACROMOLECULES
    MICHAEL FLESSNER; Fiscal Year: 2004
    ....
  51. Prenatal Corticosteroid Impact on Hippocampus
    LIBOR VELISEK; Fiscal Year: 2004
    ..The data of this proposal will be critical for determining long-term adverse effects of multiple course prenatal corticosteroid therapy and for the ameliorating these effects in the offspring. ..
  52. MIBG ANALOGUE RADIOPHARMACEUTICALS
    Ganesan Vaidyanathan; Fiscal Year: 2001
    ..Strategies to augment tumor-to-normal tissue ratios will be investigated. The outcome of this study should help improve the endoradiotherapy of neuroendocrine tumors and possibly of medulloblastoma. ..
  53. Treatments for Nicotine Dependence: Brain Mechanisms
    Arthur Brody; Fiscal Year: 2005
    ..abstract_text> ..
  54. NEURAL SUBSTRATES OF THE ACUTE EFFECTS OF ETHANOL
    Linda Porrino; Fiscal Year: 2002
    ....
  55. Oxalate-Induced Renal Scarring and Crystal Retention
    JOHN LIESKE; Fiscal Year: 2003
    ..Dr. Luis Juncos has extensive experience studying the regulation of renal blood flow in vivo, and will be critical in our efforts to develop the constant infusion model of hyperoxalemia and hyperoxaluria. ..
  56. Dopamine function in social phobia & related conditions
    Franklin Schneier; Fiscal Year: 2006
    ..Better understanding of the neurocircuitry associated with GSP holds promise for improving diagnosis and treatment strategies. ..
  57. Pharmacogenetics of Methadone
    C Devane; Fiscal Year: 2003
    ..This study will form the basis for subsequent studies which should provide a more rational basis for dosing of methadone in pregnant addicts. ..
  58. Novel Polyamine-conjugated Dendrimers for Pretargeted Chemotherapy of Ovarian Can
    SRINATH PALAKURTHI; Fiscal Year: 2006
    ..This novel approach reduces the toxic side effects associated with the chemotherapeutics used for the ovarian cancer treatment. [unreadable] [unreadable] [unreadable] [unreadable]..
  59. Acoustic Interference on Attention in HIV Patients
    Dardo Tomasi; Fiscal Year: 2003
    ..More generally, this study will also improve the understanding of the neural effects of acoustic noise interference during fMRI studies in healthy populations. ..
  60. Neurochemistry of Nicotine Dependence in Schizophrenia
    Wynne Schiffer; Fiscal Year: 2004
    ..Or increase inhibitory activity with the GABA agonist, gamma-vinyl GABA, prior to the nicotine challenge. We hope to guide the development of novel therapies for dual-diagnosis schizophrenia. ..
  61. BRAIN SEROTONIN TRANSPORTER IN ECSTASY AND MDA USERS
    Stephen Kish; Fiscal Year: 2007
    ..More broadly, our data will help define the contribution of different neuroanatomical components of the brain serotonin system to human behavior. ..
  62. Cell Biology of Human Thiamine Transporters
    VEEDAMALI SUBRAMANIAN; Fiscal Year: 2005
    ....
  63. Center For Aging
    John Morris; Fiscal Year: 2006
    ..Dr. Morris is firmly committed to accomplishing these aims and, with this award and with outstanding institutional support, to establishing a preeminent Center for Aging at Washington University. ..
  64. BRAIN PATHOPHYSIOLOGY IN ANXIETY DISORDERS
    GREGORY SULLIVAN; Fiscal Year: 2008
    ..Through such work, he seeks to contribute to the understanding of the pathophysiology of PD in order to suggest improved therapeutics for this devastating and underrecognized brain disorder. ..
  65. Amyloid Imaging in Frontotemporal Dementia and Alzheimer's Disease
    William Jagust; Fiscal Year: 2009
    ..PIB could become a diagnostic tool that is useful in diagnosing AD and FTLD during life. This will be especially important as new treatments for both disorders are developed. ..
  66. Oxalate & Crystal Renal Phenotypes: A Microarray Study
    Susan Ruth Marengo; Fiscal Year: 2003
    ..The long term objective of this work is to establish the mechanism of oxalate induced damage in the kidney. ..
  67. A Seven Tesla MRI System for Small Animals MRI/MRS
    Robert Knight; Fiscal Year: 2007
    ..This Shared Instrumentation Grant will partially supply the funds to bring the present MRI/MRS system up to current standards, with HFHS supplying the rest. [unreadable] [unreadable] [unreadable]..
  68. NMR STUDIES OF HEMORRHAGIC TRANSFORMATION IN ISCHEMIA
    Robert Knight; Fiscal Year: 2002
    ....
  69. Enhance Effectiveness of Anti-HIV Drugs in the CNS
    Jashvant Unadkat; Fiscal Year: 2003
    ..To test our hypothesis, using PET, that inhibition of P-gp in creases the exposure of CNS to l"1CJ-verapamil and, by inference, protease inhibitors. ..