isotopes

Summary

Summary: Atomic species differing in mass number but having the same atomic number. (Grant & Hackh's Chemical Dictionary, 5th ed)

Top Publications

  1. pmc Source partitioning using stable isotopes: coping with too much variation
    Andrew C Parnell
    School of Mathematical Sciences, University College Dublin, Dublin, Ireland
    PLoS ONE 5:e9672. 2010
  2. ncbi Comparing isotopic niche widths among and within communities: SIBER - Stable Isotope Bayesian Ellipses in R
    Andrew L Jackson
    Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland
    J Anim Ecol 80:595-602. 2011
  3. pmc A method for investigating population declines of migratory birds using stable isotopes: origins of harvested lesser scaup in North America
    Keith A Hobson
    Environment Canada, Saskatoon, Saskatchewan, Canada
    PLoS ONE 4:e7915. 2009
  4. ncbi Isotopic ecology ten years after a call for more laboratory experiments
    Carlos Martinez del Rio
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071 3166, USA
    Biol Rev Camb Philos Soc 84:91-111. 2009
  5. ncbi Combining stable-isotope (deltaD) and band recovery data to improve probabilistic assignment of migratory birds to origin
    Steven L Van Wilgenburg
    Environment Canada, 11 Innovation Blvd, Saskatoon, Saskatchewan S7N 3H5, Canada
    Ecol Appl 21:1340-51. 2011
  6. pmc Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation
    K F Stupic
    Sir Peter Mansfield Magnetic Resonance Centre, School of Clinical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Phys Med Biol 56:3731-48. 2011
  7. ncbi Reproductive effort, molting latitude, and feather color in a migratory songbird
    D Ryan Norris
    Department of Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Science 306:2249-50. 2004
  8. pmc Pathway to cryogen free production of hyperpolarized Krypton-83 and Xenon-129
    Joseph S Six
    University of Nottingham, School of Clinical Sciences, Sir Peter Mansfield Magnetic Resonance Centre, Nottingham, United Kingdom
    PLoS ONE 7:e49927. 2012
  9. ncbi Stable isotopes and elasmobranchs: tissue types, methods, applications and assumptions
    N E Hussey
    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, ON N9B 3P4, Canada
    J Fish Biol 80:1449-84. 2012
  10. pmc Quantitative evaluation of scintillation camera imaging characteristics of isotopes used in liver radioembolization
    Mattijs Elschot
    Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e26174. 2011

Detail Information

Publications314 found, 100 shown here

  1. pmc Source partitioning using stable isotopes: coping with too much variation
    Andrew C Parnell
    School of Mathematical Sciences, University College Dublin, Dublin, Ireland
    PLoS ONE 5:e9672. 2010
    ..Key to much of this work is the use of mixing models to estimate the proportion of sources contributing to a mixture such as in diet estimation...
  2. ncbi Comparing isotopic niche widths among and within communities: SIBER - Stable Isotope Bayesian Ellipses in R
    Andrew L Jackson
    Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland
    J Anim Ecol 80:595-602. 2011
    ..The computational code to calculate the new metrics is implemented in the free-to-download package Stable Isotope Analysis for the R statistical environment...
  3. pmc A method for investigating population declines of migratory birds using stable isotopes: origins of harvested lesser scaup in North America
    Keith A Hobson
    Environment Canada, Saskatoon, Saskatchewan, Canada
    PLoS ONE 4:e7915. 2009
    ..This is especially true for species that breed in remote northern areas where field-based demographic assessments are logistically challenging...
  4. ncbi Isotopic ecology ten years after a call for more laboratory experiments
    Carlos Martinez del Rio
    Department of Zoology and Physiology, University of Wyoming, Laramie, WY 82071 3166, USA
    Biol Rev Camb Philos Soc 84:91-111. 2009
    About 10 years ago, reviews of the use of stable isotopes in animal ecology predicted explosive growth in this field and called for laboratory experiments to provide a mechanistic foundation to this growth...
  5. ncbi Combining stable-isotope (deltaD) and band recovery data to improve probabilistic assignment of migratory birds to origin
    Steven L Van Wilgenburg
    Environment Canada, 11 Innovation Blvd, Saskatoon, Saskatchewan S7N 3H5, Canada
    Ecol Appl 21:1340-51. 2011
    ..We show that likelihood-based assignments of geographic origins can provide improved spatial resolution when models of migration direction are combined with assignments based on deltaD analysis of feathers...
  6. pmc Effects of pulmonary inhalation on hyperpolarized krypton-83 magnetic resonance T1 relaxation
    K F Stupic
    Sir Peter Mansfield Magnetic Resonance Centre, School of Clinical Sciences, University of Nottingham, Nottingham, NG7 2RD, UK
    Phys Med Biol 56:3731-48. 2011
    ..Further, the (83)Kr T(1) relaxation times in excised lungs were unaffected by the presence of up to 40% oxygen in the hp gas mixture. The results support the possible importance of (83)Kr as a biomarker for evaluating lung function...
  7. ncbi Reproductive effort, molting latitude, and feather color in a migratory songbird
    D Ryan Norris
    Department of Biology, Queen s University, Kingston, Ontario K7L 3N6, Canada
    Science 306:2249-50. 2004
    ..Using stable hydrogen isotopes, we show that male American redstarts investing in high levels of reproduction late in the season adopt a unique ..
  8. pmc Pathway to cryogen free production of hyperpolarized Krypton-83 and Xenon-129
    Joseph S Six
    University of Nottingham, School of Clinical Sciences, Sir Peter Mansfield Magnetic Resonance Centre, Nottingham, United Kingdom
    PLoS ONE 7:e49927. 2012
    ..Aspects of SEOP specific to the two noble gas isotopes are discussed and compared with current theoretical opinions...
  9. ncbi Stable isotopes and elasmobranchs: tissue types, methods, applications and assumptions
    N E Hussey
    Great Lakes Institute for Environmental Research, University of Windsor, 401 Sunset Avenue, ON N9B 3P4, Canada
    J Fish Biol 80:1449-84. 2012
    ..Recommendations are made for future SIA experimental work that would improve understanding of stable-isotope dynamics and advance their application in the study of sharks, skates and rays...
  10. pmc Quantitative evaluation of scintillation camera imaging characteristics of isotopes used in liver radioembolization
    Mattijs Elschot
    Department of Radiology and Nuclear Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 6:e26174. 2011
    ..The aim of this study is to quantitatively evaluate and compare the imaging characteristics of these three isotopes, in order that imaging protocols can be optimized and RE studies with varying isotopes can be compared.
  11. ncbi Determining biological tissue turnover using stable isotopes: the reaction progress variable
    Thure E Cerling
    Department of Geology and Geophysics, University of Utah, Salt Lake City, UT 84112 0111, USA
    Oecologia 151:175-89. 2007
    ..Previous growth models have been for exponential growth; the approach here can be used for several different growth models...
  12. pmc High-resolution quantitative imaging of mammalian and bacterial cells using stable isotope mass spectrometry
    Claude Lechene
    National Resource for Imaging Mass Spectrometry, Harvard Medical School and Department of Medicine, Brigham and Women s Hospital, Cambridge, MA 02139, USA
    J Biol 5:20. 2006
    ..imaging mass spectrometry (MIMS), which combines a new generation of SIMS instrument with sophisticated ion optics, labeling with stable isotopes, and quantitative image-analysis software, was developed to study biological materials.
  13. pmc Quantifying inter- and intra-population niche variability using hierarchical bayesian stable isotope mixing models
    Brice X Semmens
    Northwest Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington, USA
    PLoS ONE 4:e6187. 2009
    ....
  14. ncbi Resolving temporal variation in vertebrate diets using naturally occurring stable isotopes
    F Dalerum
    Department of Zoology, Stockholm University, 10691 Stockholm, Sweden
    Oecologia 144:647-58. 2005
    ..Ratios of naturally occurring stable isotopes in animal tissues are a combination of the source elements and tissue specific fractionation processes, and can ..
  15. ncbi Experimental investigation and numerical simulation of 3He gas diffusion in simple geometries: implications for analytical models of 3He MR lung morphometry
    J Parra-Robles
    Academic Unit of Radiology, Royal Hallamshire Hospital, University of Sheffield, UK
    J Magn Reson 204:228-38. 2010
    ..The results presented here demonstrate that physical assumptions of the cylinder model are not valid for large diffusion gradient strengths (above approximately 15 mT/m), which are commonly used for (3)He ADC measurements in human lungs...
  16. pmc Isotopic values of plants in relation to water availability in the Eastern Mediterranean region
    Gideon Hartman
    Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, Deutscher Platz 6, 04103 Leipzig, Germany
    Oecologia 162:837-52. 2010
    ..From these results it can be concluded that water availability is the primary factor controlling C and N isotope variability in plant communities in the Eastern Mediterranean...
  17. pmc Geographic variation of strontium and hydrogen isotopes in avian tissue: implications for tracking migration and dispersal
    Megan J Sellick
    Department of Integrative Biology, University of Guelph, Guelph, Ontario, Canada
    PLoS ONE 4:e4735. 2009
    b>Isotopes can provide unique solutions to fundamental problems related to the ecology and evolution of migration and dispersal because prior movements of individuals can theoretically be tracked from tissues collected from a single capture...
  18. ncbi Spin biochemistry: magnetic 24Mg-25Mg-26Mg isotope effect in mitochondrial ADP phosphorylation
    Anatoly L Buchachenko
    NN Semenov Institute for Chemical Physics, Russian Academy of Sciences, Moscow
    Cell Biochem Biophys 43:243-51. 2005
    ..Therefore, the key mitochondrial phosphotransferases work as a magnesium nuclear spin mediated molecular machines...
  19. pmc Determination of complex isotopomer patterns in isotopically labeled compounds by mass spectrometry
    Mark E Jennings
    Department of Chemistry, University of Vermont, Burlington, Vermont 05405, USA
    Anal Chem 77:6435-44. 2005
    ..In examples shown here, isotopomer uncertainties were calculated with relative standard errors of <1% from good quality mass spectral data...
  20. ncbi Incorporating uncertainty and prior information into stable isotope mixing models
    Jonathan W Moore
    National Marine Fisheries Service, Northwest Fisheries Science Center, 2725 Montlake Boulevard East, Seattle, WA 98112, USA
    Ecol Lett 11:470-80. 2008
    Stable isotopes are a powerful tool for ecologists, often used to assess contributions of different sources to a mixture (e.g. prey to a consumer). Mixing models use stable isotope data to estimate the contribution of sources to a mixture...
  21. ncbi Lead (Pb) isotopic fingerprinting and its applications in lead pollution studies in China: a review
    Hefa Cheng
    State Key Laboratory of Organic Geochemistry, Guangzhou Institute of Geochemistry, Chinese Academy of Sciences, Guangzhou 510640, PR China
    Environ Pollut 158:1134-46. 2010
    ..Further methodological developments and more widespread instrument availability are expected to make isotopic fingerprinting one of the key tools in lead pollution investigation...
  22. ncbi Chronic obstructive pulmonary disease: quantification of bronchodilator effects by using hyperpolarized ³He MR imaging
    Miranda Kirby
    Imaging Research Laboratories, Robarts Research Institute, London, ON, Canada
    Radiology 261:283-92. 2011
    ..To evaluate short-acting bronchodilator effects in chronic obstructive pulmonary disease (COPD) by using hyperpolarized helium 3 (³He) magnetic resonance (MR) imaging, spirometry, and plethysmography...
  23. pmc Inferring foraging areas of nesting loggerhead turtles using satellite telemetry and stable isotopes
    Simona A Ceriani
    Marine Turtle Research Group and Department of Biological Sciences, University of Central Florida, Orlando, Florida, United States of America
    PLoS ONE 7:e45335. 2012
    In recent years, the use of intrinsic markers such as stable isotopes to link breeding and foraging grounds of migratory species has increased...
  24. ncbi Volumetry of ventilated airspaces by 3He MRI: preliminary results
    H U Kauczor
    Department of Radiology, Johannes Gutenberg University, Mainz, Germany
    Invest Radiol 36:110-4. 2001
    ..To develop a validated post-processing routine for volumetry of the ventilated airspaces by 3He MRI...
  25. ncbi Isotopic discrimination between food and blood and feathers of captive penguins: implications for dietary studies in the wild
    Yves Cherel
    Centre d Etudes Biologiques de Chize, Unite Propre de Recherche 1934 du Centre National de la Recherche Scientifique, BP 14, 79360 Villiers en Bois, France
    Physiol Biochem Zool 78:106-15. 2005
    Using measurements of naturally occurring stable isotopes to reconstruct diets or source of feeding requires quantifying isotopic discrimination factors or the relationships between isotope ratios in food and in consumer tissues...
  26. ncbi Magnesium isotope effects in enzymatic phosphorylation
    Anatoly L Buchachenko
    N N Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russia
    J Phys Chem B 112:2548-56. 2008
    ..Similar effects have been also found for the pyruvate kinase. Magnetic field dependence of enzymatic phosphorylation is in agreement with suggested ion-radical mechanism...
  27. pmc Linking hydrogen (δ2H) isotopes in feathers and precipitation: sources of variance and consequences for assignment to isoscapes
    Keith A Hobson
    Environment Canada, Saskatoon, Saskatchewan, Canada
    PLoS ONE 7:e35137. 2012
    ..Naturally occurring stable isotopes of H (δ(2)H) in feathers provide an alternative intrinsic marker of animal origin due to the predictable spatial ..
  28. pmc Cross-hemisphere migration of a 25 g songbird
    Franz Bairlein
    Institute of Avian Research Vogelwarte Helgoland, An der Vogelwarte 21, Wilhelmshaven 26386, Germany
    Biol Lett 8:505-7. 2012
    ..Our results provide the first evidence of a migratory songbird capable of linking African ecosystems of the Old World with Arctic regions of the New World...
  29. ncbi Stable isotopes may provide evidence for starvation in reptiles
    Marshall D McCue
    Department of Biological Sciences, 601 Science Engineering, 1 University of Arkansas, Fayetteville, AR 72701, USA
    Rapid Commun Mass Spectrom 22:2307-14. 2008
    ..The results of this study suggest that naturally occurring stable isotopes might ultimately have some utility for characterizing nitrogen and carbon stress among free-living reptiles.
  30. pmc Strong evidence for terrestrial support of zooplankton in small lakes based on stable isotopes of carbon, nitrogen, and hydrogen
    Jonathan J Cole
    Cary Institute of Ecosystem Studies, Millbrook, NY 12545, USA
    Proc Natl Acad Sci U S A 108:1975-80. 2011
    ..Here, we adopt a unique approach by using stable isotopes of H, C, and N to estimate terrestrial support to zooplankton in two contrasting lakes...
  31. ncbi Combined helium-3/proton magnetic resonance imaging measurement of ventilated lung volumes in smokers compared to never-smokers
    Neil Woodhouse
    Unit Academic of Radiology, University of Sheffield, Royal Hallamshire Hospital, Sheffield, UK
    J Magn Reson Imaging 21:365-9. 2005
    ....
  32. ncbi Evaluation of asthma with hyperpolarized helium-3 MRI: correlation with clinical severity and spirometry
    Eduard E de Lange
    University of Virginia Health Sciences System, Department of Radiology, HSC 800170, Charlottesville, VA 22908, USA
    Chest 130:1055-62. 2006
    ..The objective of this study was to compare the extent of H(3)HeMR ventilation defects with measures of asthma severity and spirometry...
  33. ncbi Natural abundance variations in stable isotopes and their potential uses in animal physiological ecology
    L Z Gannes
    Department of Ecology and Evolutionary Biology, Princeton University, NJ 08544 1003, USA
    Comp Biochem Physiol A Mol Integr Physiol 119:725-37. 1998
    ..by plant physiological ecologists and by paleontologists, and recently ecologists have adopted the use of stable isotopes to measure ecosystem patterns and processes...
  34. ncbi Correcting mass isotopomer distributions for naturally occurring isotopes
    Wouter A van Winden
    Department of Bioprocess Technology, Faculty of Applied Sciences, Delft University of Technology, The Netherlands
    Biotechnol Bioeng 80:477-9. 2002
    ..Doing so, simulated mass distributions must be corrected for the presence of naturally occurring isotopes. A method that was recently introduced for this purpose consists of consecutive correction steps for each isotope ..
  35. pmc Individual specialists in a generalist population: results from a long-term stable isotope series
    Hannah B Vander Zanden
    Archie Carr Center for Sea Turtle Research and Department of Biology, University of Florida, PO Box 118525, Gainesville, FL 32611, USA
    Biol Lett 6:711-4. 2010
    ..Using stable isotopes of nitrogen and carbon, we examined the resource use patterns (integration of diet, habitat and geographical ..
  36. ncbi Site-specific mass tagging with stable isotopes in proteins for accurate and efficient protein identification
    X Chen
    CST 9, BN 2, MS M888, Chemical Science and Technology Division, Los Alamos National Laboratory, New Mexico, USA
    Anal Chem 72:1134-43. 2000
    ..This method of identifying unique proteins can also be extended to protein complexes and will significantly increase data search specificity, efficiency, and accuracy for protein identifications...
  37. ncbi Erroneous behaviour of MixSIR, a recently published Bayesian isotope mixing model: a discussion of Moore & Semmens (2008)
    Andrew L Jackson
    Department of Zoology, School of Natural Sciences, Trinity College Dublin, Dublin 2, Ireland
    Ecol Lett 12:E1-5. 2009
    ..Moreover, MixSIR uses a formulation for a prior distribution that results in an opaque and unintuitive covariance structure...
  38. ncbi BiPS, a photocleavable, isotopically coded, fluorescent cross-linker for structural proteomics
    Evgeniy V Petrotchenko
    Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA
    Mol Cell Proteomics 8:273-86. 2009
    ....
  39. ncbi Functional MRI of the lung using hyperpolarized 3-helium gas
    Edwin J R van Beek
    Academic Unit of Radiology, University of Sheffield, Sheffield, UK
    J Magn Reson Imaging 20:540-54. 2004
    ..Four different techniques that have been used in various human investigations are discussed: ventilation distribution, ventilation dynamics, and small airway evaluation using diffusion imaging and oxygen uptake assessment...
  40. pmc Magnetic isotope effect of magnesium in phosphoglycerate kinase phosphorylation
    Anatoly L Buchachenko
    N N Semenov Institute for Chemical Physics, Russian Academy of Sciences, Kosygin Street 4, Moscow 119991, Russia
    Proc Natl Acad Sci U S A 102:10793-6. 2005
    ..The chemical mechanism of this phenomenon is discussed. A key element of the mechanism proposed is a nonradical pair formation in which (25)Mg(+) radical cation and phosphate oxyradical are involved...
  41. pmc Isotopica: a tool for the calculation and viewing of complex isotopic envelopes
    Jorge Fernandez-de-Cossio
    Center for Genetic Engineering and Biotechnology, P O Box 6162, Havana, Cuba
    Nucleic Acids Res 32:W674-8. 2004
    ..application Isotopica has been developed as an aid to the interpretation of ions that contain naturally occurring isotopes in a mass spectrum...
  42. ncbi Single-acquisition sequence for the measurement of oxygen partial pressure by hyperpolarized gas MRI
    M C Fischer
    Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104, USA
    Magn Reson Med 52:766-73. 2004
    ..Numerical simulations of the time evolution of the oxygen concentration were performed. Simulation results are presented to support the experimental data. Various parameter regimes were experimentally and numerically investigated...
  43. pmc Biological fractionation of lead isotopes in Sprague-Dawley rats lead poisoned via the respiratory tract
    Jing Wu
    School of Public Health, Peking University, Haidian District, Beijing, People s Republic of China
    PLoS ONE 7:e52462. 2012
    ..An animal experiment was conducted to explore the biological fractionation of lead isotopes in biological systems.
  44. ncbi Organochlorine compounds and stable isotopes indicate bottlenose dolphin subpopulation structure around the Iberian Peninsula
    A Borrell
    GRUMM, Dept of Animal Biology, University of Barcelona, Barcelona 08071, Spain
    Environ Int 32:516-23. 2006
    ....
  45. ncbi Chemostratigraphic evidence of Deccan volcanism from the marine osmium isotope record
    G Ravizza
    Department of Geology and Geophysics, University of Hawaii, Honolulu, HI 96822 2225, USA
    Science 302:1392-5. 2003
    ....
  46. ncbi (3)he-MRI-based measurements of intrapulmonary p(O2) and its time course during apnea in healthy volunteers: first results, reproducibility, and technical limitations
    A J Deninger
    Department of Physics, University of Mainz, Staudingerweg 7, D 55099 Mainz, Germany
    NMR Biomed 13:194-201. 2000
    ..Also, regional differences of both p(0) and R were observed. A correlation between p(0) and R was apparent. Finally, we discuss limitations of the double acquisition approach...
  47. ncbi Assignment of unknown persons to their geographical origin by determination of stable isotopes in hair samples
    Elisabeth Mützel Rauch
    Institute of Forensic Medicine, Ludwig Maximilians University Munich, Nubbaumstr 26, 80336, Munich, Germany
    Int J Legal Med 123:35-40. 2009
    ..The possibilities and limitations of this method in its current state are demonstrated and discussed...
  48. pmc Reexamination of magnetic isotope and field effects on adenosine triphosphate production by creatine kinase
    Darragh Crotty
    School of Physics and Centre for Research on Adaptive Nanostructures and Nanodevices, Trinity College, Dublin 2, Ireland
    Proc Natl Acad Sci U S A 109:1437-42. 2012
    ....
  49. ncbi Lead isotopes as a tracer of Pb origin in the sediments from Beijiang River, South China
    Bo Gao
    State Key Laboratory of Simulation and Regulation of Water Cycle in River Basin, China Institute of Water Resources and Hydropower Research, Beijing, 100038, China
    Water Sci Technol 66:2613-9. 2012
    ..The mining activities and metal smelting processing was the main source of Pb pollution in this region...
  50. ncbi Lead isotopes in the western North Atlantic: transient tracers of pollutant lead inputs
    A J Véron
    Géosciences de l Environnement, CNRS UMR6536, CEREGE, Provence, France
    Environ Res 78:104-11. 1998
    ..The transient character of those isotopic signatures also allows calculations of pollutant lead penetration rates into the mixed layer and upper thermocline of the western Sargasso Sea...
  51. pmc Assessment of renal function by the stable oxygen and hydrogen isotopes in human blood plasma
    Tai Chih Kuo
    College of Medicine, Taipei Medical University, Taipei, Taiwan
    PLoS ONE 7:e32137. 2012
    Water (H(2)O) is the most abundant and important molecule of life. Natural water contains small amount of heavy isotopes. Previously, few animal model studies have shown that the isotopic composition of body water could play important ..
  52. pmc Estimating the diets of animals using stable isotopes and a comprehensive Bayesian mixing model
    John B Hopkins
    Department of Ecology, Montana State University, Bozeman, Montana, United States of America
    PLoS ONE 7:e28478. 2012
    ..IsotopeR's user interface (in R) will provide researchers a user-friendly tool for SIMM analysis. The model is also applicable for use in paleontology, archaeology, and forensic studies as well as estimating pollution inputs...
  53. ncbi Role of stable isotopes in life--testing isotopic resonance hypothesis
    Roman A Zubarev
    Division of Physiological Chemistry I, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden
    Genomics Proteomics Bioinformatics 9:15-20. 2011
    Stable isotopes of most important biological elements, such as C, H, N and O, affect living organisms. In rapidly growing species, deuterium and to a lesser extent other heavy isotopes reduce the growth rate...
  54. ncbi The usefulness of stable isotopes in nutrition and human health: the application of mass spectrometry and 13C-breath tests to detect helicobacter pylori infection
    A Barrado
    Physics Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Arch Latinoam Nutr 54:27-43, 5-23. 2004
    ..Improved methods for the diagnosis and follow up treatment of the infection have been developed. Use of stable isotopes as non-invasive and safe diagnostic methods, namely (13C) breath tests, has been the key to a new era of research ..
  55. ncbi Isotopes for improved management of nitrate pollution in aqueous resources: review of surface water field studies
    Angelika Nestler
    European Commission, Joint Research Centre JRC, Institute for Reference Materials and Measurements IRMM, Retieseweg 111, 2440, Geel, Belgium
    Environ Sci Pollut Res Int 18:519-33. 2011
    ..Isotope data can support the identification of nitrate pollution sources and natural attenuation processes of nitrate...
  56. ncbi Stable lead isotopes in environmental health with emphasis on human investigations
    Brian Gulson
    Graduate School of the Environment, Macquarie University, Sydney NSW, Australia
    Sci Total Environ 400:75-92. 2008
    There has been widespread use of stable lead isotopes in the earth sciences for more than 40 years focussed on the origin and age of rocks and minerals with lesser application in environmental investigations where the emphasis has been ..
  57. ncbi Use of lead isotope ratios to identify sources of lead exposure in Alaska Natives
    Manish M Patel
    Centers for Disease Control and Prevention, National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Health Studies Branch, Anchorage, USA
    Int J Circumpolar Health 67:261-8. 2008
    ..The Centers for Disease Control and Prevention (CDC) and Alaskan health officials conducted a cross-sectional exposure assessment and used isotope ratios (IR) to test that assumption...
  58. ncbi Hyperpolarized 3helium magnetic resonance ventilation imaging of the lung in cystic fibrosis: comparison with high resolution CT and spirometry
    Colm J McMahon
    Department of Radiology, St Vincent s University Hospital, Dublin 4, Ireland
    Eur Radiol 16:2483-90. 2006
    ..01, respectively) than HRCT (R = +/-0.72 and +/-0.81, p < 0.05, respectively). This study showed that 3He MRI correlates strongly with structural HRCT abnormalities and is a stronger correlate of spirometry than HRCT in CF...
  59. ncbi Evaluation of zinc, cadmium and lead isotope fractionation during smelting and refining
    Alyssa E Shiel
    Pacific Centre for Isotopic and Geochemical Research, Department of Earth and Ocean Sciences, University of British Columbia UBC, Vancouver, BC, Canada V6T 1Z4
    Sci Total Environ 408:2357-68. 2010
    ..C., Canada. Significant fractionation of Zn and Cd isotopes during processing of ZnS and PbS ore concentrates is demonstrated by the total variation in delta(66/64)Zn and ..
  60. ncbi Fundamentals and systematics of the non-statistical distributions of isotopes in natural compounds
    Hanns Ludwig Schmidt
    Lehrstuhl fur Biologische Chemie, Technische Universitat Munchen, 85350, Freising Weihenstephan, Munich, Germany
    Naturwissenschaften 90:537-52. 2003
    The intermolecular and intramolecular non-statistical distribution of the isotopes of the bio-elements in natural compounds must obviously be controlled by logical principles...
  61. ncbi Lead isotopes and lead shot ingestion in the globally threatened marbled teal (Marmaronetta angustirostris) and white-headed duck (Oxyura leucocephala)
    Fredrik Svanberg
    Department of Environmental Toxicology, Evolutionary Biology Centre, Uppsala University, Norbyvagen 18A, SE 752 36 Uppsala, Sweden
    Sci Total Environ 370:416-24. 2006
    ..The principal source of lead in many of these birds was, however, most likely lead shot, as supported by the similar isotopic ratios, high lead concentrations in tissues and evidence of ingested shot...
  62. ncbi Influence of different organic fertilizers on quality parameters and the delta(15)N, delta(13)C, delta(2)H, delta(34)S, and delta(18)O values of orange fruit (Citrus sinensis L. Osbeck)
    Paolo Rapisarda
    CRA Centro di Ricerca per l Agrumicoltura e le Colture Mediterranee, Corso Savoia 190, Acireale CT, Italy
    J Agric Food Chem 58:3502-6. 2010
    ..These treatments also did not effect differences in the delta(13)C, delta(2)H, delta(34)S, and delta(18)O values of fruit...
  63. ncbi Using stable isotopes to unravel and predict the origins of great cormorants (Phalacrocorax carbo sinensis) overwintering at Kinmen
    Yuan Mou Chang
    Department of Biology, Brigham Young University, Provo, UT 84602 5181, USA
    Rapid Commun Mass Spectrom 22:1235-44. 2008
    ..We show that analyses of multiple stable isotopes (delta(13)C, delta(15)N, delta(18)O and deltaD) can provide an understanding of the number of breeding ..
  64. ncbi Merging parametric active contours within homogeneous image regions for MRI-based lung segmentation
    Nilanjan Ray
    Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, VA 22904, USA
    IEEE Trans Med Imaging 22:189-99. 2003
    ..This technology plays a key role in computing the functional air space from MR images that use hyperpolarized 3He gas as a contrast agent...
  65. ncbi Isotopic identification of the sources of lead contamination for white storks (Ciconia ciconia) in a marshland ecosystem (Doñana, S.W. Spain)
    Andrew A Meharg
    Department of Plant and Soil Science, Aberdeen University Cruickshank Building, St Machar Drive, Aberdeen AB24 3UU, UK
    Sci Total Environ 300:81-6. 2002
    ..Guadiamar and the R. Guadalquivir (of which the Guadiamar is a tributary) was also conducted to place the white stork colony lead exposure in the context of the spatial contamination of the storks' habitat...
  66. ncbi Isotope characteristics of vegetables and wheat from conventional and organic production
    Hanns Ludwig Schmidt
    isolab GmbH, Woelkestr 9 1, 85301, Schweitenkirchen, Germany
    Isotopes Environ Health Stud 41:223-8. 2005
    ..6 per thousand, respectively. The unexpected relative high 15N-enrichments of vegetables from integrated production are discussed as originating, at least partially, from 15N-enrichment in the soil by NH3 evaporation and denitrification...
  67. ncbi Application of enriched stable isotopes as tracers in biological systems: a critical review
    Stefan Sturup
    Department of Pharmaceutics and Analytical Chemistry, Faculty of Pharmaceutical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100, Copenhagen, Denmark
    Anal Bioanal Chem 390:541-54. 2008
    The application of enriched stable isotopes of minerals and trace elements as tracers in biological systems is a rapidly growing research field that benefits from the many new developments in inorganic mass spectrometric instrumentation, ..
  68. ncbi Selenium supplementation affects the retention of stable isotopes of selenium in human subjects consuming diets low in selenium
    J W Finley
    Department of Agriculture, Grand Forks Human Nutrition Research Center, ND 58202, USA
    Br J Nutr 82:357-60. 1999
    ....
  69. ncbi Gardening by the psychomyiid caddisfly Tinodes waeneri: evidence from stable isotopes
    Nicola L Ings
    School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road, London E1 4NS, UK
    Oecologia 163:127-39. 2010
    ..Nevertheless, T. waeneri galleries do act as a fertilised garden. 'Gardening' appears to be widespread in this species, and may affect productivity and patterns of nitrogen retention within the stony littoral of lakes...
  70. pmc Applications of isotopes in advancing structural and functional heparanomics
    Vy M Tran
    Department of Bioengineering, University of Utah, Salt Lake City, UT 84112, USA
    Anal Bioanal Chem 399:559-70. 2011
    ..This review focuses on the applications of isotopes, both radioisotopes and stable isotopes, in the structural elucidation of the complex heparanome at the ..
  71. ncbi Coupling stable isotopes with bioenergetics to estimate interspecific interactions
    Stephane Caut
    Ecologie, Systematique et Evolution, UMR CNRS 8079, Universite Paris Sud, Orsay, France
    Ecol Appl 16:1893-900. 2006
    ..Here, we describe a methodology for estimating interspecific interactions by combining stable isotopes with bioenergetics...
  72. ncbi Absorption of selenium from wheat, garlic, and cod intrinsically labeled with Se-77 and Se-82 stable isotopes
    Tom E Fox
    Institute of Food Research, Norwich Research Park, Norwich NR4 7UA, UK
    Int J Vitam Nutr Res 75:179-86. 2005
    ..Wheat, garlic, and cod fish were intrinsically labeled with Se-77 or Se-82 stable isotopes. Labeled meals were fed in random order to 14 adults, with a minimum washout period of six weeks between each ..
  73. ncbi Stable isotopes and the international system of units
    C Slater
    Department of Child Health, University of Glasgow, Yorkhill Hospitals, Glasgow G3 8SJ, UK
    Rapid Commun Mass Spectrom 15:1270-3. 2001
    ..The introduction of continuous-flow techniques heralded a huge expansion in the use of stable isotopes in biomedical and environmental sciences, yet there is no consensus on the appropriate units, especially in the ..
  74. ncbi Stable isotopes as one of nature's ecological recorders
    Jason B West
    Department of Biology, University of Utah, Salt Lake City, UT 84115, USA
    Trends Ecol Evol 21:408-14. 2006
    Analyses of the natural variation in stable isotopes of components of ecological systems have provided new insights into how these systems function across paleoecological to modern timescales and across a wide range of spatial scales...
  75. ncbi Quantitative measurement of regional lung ventilation using 3He MRI
    Anselm J Deninger
    Amersham Health R and D, Medeon, SE 205 12 Malmö, Sweden
    Magn Reson Med 48:223-32. 2002
    ..The simulations revealed that, at presently attainable signal-to-noise ratios, the ventilation parameter can be determined with a relative uncertainty of <5% over a wide range of values...
  76. ncbi Application of nontraditional stable-isotope systems to the study of sources and fate of metals in the environment
    Dominik J Weiss
    Department of Earth Science and Engineering, Imperial College London
    Environ Sci Technol 42:655-64. 2008
  77. ncbi Combining sources in stable isotope mixing models: alternative methods
    Donald L Phillips
    US Environmental Protection Agency, Office of Research and Development, Western Ecology Division, National Health and Environmental Effects Research Laboratory, 200 SW 35th St, Corvallis, OR, 97333, USA
    Oecologia 144:520-7. 2005
    ..epa.gov/wed/pages/models/isotopes/isoerror1_04.htm)...
  78. ncbi Identifying sources of lead exposure for children, with lead concentrations and isotope ratios
    P Glorennec
    EHESP School of Public Health, Rennes, France
    J Occup Environ Hyg 7:253-60. 2010
    ..However, systematic use should be supported by cost-effectiveness analysis on a larger and more representative population of elevated BLL...
  79. pmc Pre-whaling genetic diversity and population ecology in eastern Pacific gray whales: insights from ancient DNA and stable isotopes
    S Elizabeth Alter
    Department of Biological Sciences, Hopkins Marine Station, Stanford University, Pacific Grove, California, United States of America
    PLoS ONE 7:e35039. 2012
    ..Stable isotopes show minimal differences between modern and ancient gray whale foraging ecology...
  80. ncbi A whiff of oxygen before the great oxidation event?
    Ariel D Anbar
    School of Earth and Space Exploration, Arizona State University, Tempe, AZ 85287, USA
    Science 317:1903-6. 2007
    ..These findings point to the presence of small amounts of O2 in the environment more than 50 million years before the start of the Great Oxidation Event...
  81. ncbi Automatic deconvolution of isotope-resolved mass spectra using variable selection and quantized peptide mass distribution
    Peicheng Du
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Anal Chem 78:3385-92. 2006
    ..Our results compare favorably to those from a widely used commercial program...
  82. pmc Binding isotope effects: boon and bane
    Vern L Schramm
    Department of Biochemistry, Albert Einstein College of Medicine of Yeshiva University, 1300 Morris Park Avenue, Bronx, NY 10461, United States
    Curr Opin Chem Biol 11:529-36. 2007
    ..Although binding isotope effects complicate kinetic isotope effect analysis, they also provide a powerful tool for finding atomic distortion in molecular interactions...
  83. ncbi Determination of the geographical origin of green coffee by principal component analysis of carbon, nitrogen and boron stable isotope ratios
    Francesca Serra
    European Commission, Joint Research Center, Institute for Health and Consumer Protection, Physical and Chemical Exposure Unit, BEVABS, TP281, Via Fermi 2, 21020 Ispra, Italy
    Rapid Commun Mass Spectrom 19:2111-5. 2005
    ..Nonetheless, the approach using stable isotope ratios seems quite promising, and future development of this research is also discussed...
  84. ncbi Bioavailability of selenium from fish, yeast and selenate: a comparative study in humans using stable isotopes
    T E Fox
    Institute of Food Research, Colney, Norwich, UK
    Eur J Clin Nutr 58:343-9. 2004
    ....
  85. ncbi Metabolic labeling of proteins for proteomics
    Robert J Beynon
    Protein Function Group, Faculty of Veterinary Science, University of Liverpool, Crown Street, Liverpool L69 7ZJ, United Kingdom
    Mol Cell Proteomics 4:857-72. 2005
    ..Confounding issues include the metabolic lability of the amino acid precursor, incomplete labeling, and the role of protein turnover in labeling kinetics. All of these are controllable, provided that appropriate precautions are adopted...
  86. pmc Lead isotopes as a supplementary tool in the routine evaluation of household lead hazards
    R H Gwiazda
    Environmental Toxicology, University of California, Santa Cruz, California 95064, USA
    Environ Health Perspect 108:1091-7. 2000
    ..inductively coupled plasma-mass spectrometry (ICP-MS) allows rapid, accurate, and precise measurement of lead isotopes in environmental and biological samples at a lower cost than traditional methods...
  87. ncbi The quantitative analysis of uranium isotopes in the urine of the civilian population of eastern Afghanistan after Operation Enduring Freedom
    Asaf Durakovic
    Uranium Medical Research Centre, Washington, DC 20008, USA
    Mil Med 170:277-84. 2005
    The purpose of this study was to determine the concentrations and precise isotopic compositions of four uranium isotopes (234U, 235U, 236U, and 238U) in urine specimens from the civilian population of Afghanistan after Allied Forces ..
  88. ncbi Using stable isotopes to assess the bioavailability of minerals in food-fortification programs
    S A Abrams
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, USA
    Forum Nutr 56:312-3. 2003
    ..Stable isotopes provide a safe and accessible approach to providing direct evidence regarding these issues...
  89. ncbi Who eats what, where and when? Isotope-labelling experiments are coming of age
    Josh D Neufeld
    Department of Biological Sciences, University of Warwick, Coventry, UK
    ISME J 1:103-10. 2007
    ..Insight into the 'uncultivated majority' accompanies methodology that involves the incorporation of stable isotopes or radioisotopes into sub-populations of environmental samples...
  90. ncbi Assessing mineral metabolism in children using stable isotopes
    Steven A Abrams
    US Department of Agriculture Agricultural Research Service, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine and Texas Children s Hospital, Houston, Texas, USA
    Pediatr Blood Cancer 50:438-41; discussion 451. 2008
    ..These assessments can now be done safely and readily using non-radioactive, stable isotopes which are available for calcium, zinc, magnesium, and iron...
  91. pmc Long-term feeding ecology and habitat use in harbour porpoises Phocoena phocoena from Scandinavian waters inferred from trace elements and stable isotopes
    Michael C Fontaine
    MARE Centre Laboratory for Oceanology, University of Liege, B6c, Liège Sart Tilman B 4000, Belgium
    BMC Ecol 7:1. 2007
    ..along the Scandinavian coast from the North Sea to the Barents Sea using time-integrative markers: stable isotopes (delta13C, delta15N) and trace elements (Zn, Cu, Fe, Se, total Hg and Cd), in relation to habitat characteristics ..
  92. ncbi Mass spectrometry and isotopes: a century of research and discussion
    Herbert Budzikiewicz
    Institut fur Organische Chemie der Universitat zu Koln, Greinstr 4, 50939 Koln, Germany
    Mass Spectrom Rev 25:146-57. 2006
    ..especially deviations from it) played an important role in the discussion whether elements could be mixtures of isotopes. F...
  93. ncbi A palaeotemperature curve for the Precambrian oceans based on silicon isotopes in cherts
    Francois Robert
    Museum national d histoire naturelle, CNRS LEME NanoAnalyses, UMS 2679, 57 rue Cuvier, 75005 Paris, France
    Nature 443:969-72. 2006
    ....
  94. pmc Feasibility of combining MR perfusion, angiography, and 3He ventilation imaging for evaluation of lung function in a porcine model
    Cheng Hong
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Acad Radiol 12:202-9. 2005
    ..To assess the feasibility of combining magnetic resonance (MR) perfusion, angiography, and 3He ventilation imaging for the evaluation of lung function in a porcine model...
  95. ncbi Comparison of lead isotopes with source apportionment models, including SOM, for air particulates
    Brian Gulson
    Graduate School of the Environment, Macquarie University, Sydney NSW 2109, Australia
    Sci Total Environ 381:169-79. 2007
    We have measured high precision lead isotopes in PM(2...
  96. ncbi Stable isotopes in ecological studies
    David R Thompson
    National Institute of Water and Atmospheric Research Ltd NIWA, 301 Evans Bay Parade, PO Box 14 901, Wellington, New Zealand
    Oecologia 144:517-9. 2005
  97. ncbi FTIR spectroelectrochemical study of the activation and inactivation processes of [NiFe] hydrogenases: effects of solvent isotope replacement and site-directed mutagenesis
    Antonio L De Lacey
    Instituto de Catalisis, CSIC, Campus de Cantoblanco, 28049 Madrid, Spain
    J Biol Inorg Chem 9:636-42. 2004
    ..The interpretation of the experimental results is that the rate-limiting step for anaerobic inactivation is the formation from water of a micro-OH(-) bridge at the hydrogenase active site, and that Glu25 has a role in this step...
  98. ncbi Using stable isotopes to assess the bioavailability of minerals in food fortification programs
    S A Abrams
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA
    Food Nutr Bull 23:158-65. 2002
    ..Stable isotopes provide a safe and accessible method of resolving these issues by providing the proper evidence in each case...
  99. ncbi Co-registration of acquired MR ventilation and perfusion images--validation in a porcine model
    Rahim R Rizi
    Department of Radiology, Metabolic Magnetic Resonance Research and Computing Center, University of Pennsylvania, Philadelphia 19104, USA
    Magn Reson Med 49:13-8. 2003
    ..This method has potential applications in the quantitative assessment of regional alveolar ventilation and pulmonary perfusion ratio, in both normal and diseased lung...
  100. ncbi MR imaging of the lungs with hyperpolarized helium-3 gas transported by air
    J M Wild
    Academic Unit of Radiology, University of Sheffield, Royal Hallamshire Hospital, UK
    Phys Med Biol 47:N185-90. 2002
    ..In this study, the feasibility of transporting large quantities of HP gas for in vivo MR imaging from a remote production facility in Mainz, Germany, by airfreight to Sheffield, UK, was successfully demonstrated...
  101. ncbi Lead shot contribution to blood lead of First Nations people: the use of lead isotopes to identify the source of exposure
    Leonard J S Tsuji
    Department of Environment and Resource Studies, University of Waterloo, Waterloo, Ontario, Canada
    Sci Total Environ 405:180-5. 2008
    ..e., use of a shotgun) was also an important route of lead exposure. The banning of lead shotshell for all game hunting would eliminate a source of environmental lead for all people who use firearms and/or eat wild game...

Research Grants80

  1. NOVEL PET AGENT FOR MYOCARDIAL PERFUSION IMAGING
    Vijay Sharma; Fiscal Year: 2013
    ..rapid clearance from the liver, retention within the myocardium to enable delayed imaging, and based on isotopes that could potentially be generator-produced on site (rather than cyclotron produced) would facilitate wide ..
  2. Glutamate-Glutamine Metabolism in Primary Human Brain Tumors
    Anne Williamson; Fiscal Year: 2010
    ..In this grant, we will expose samples of resected primary human brain tumors to a variety of stable isotopes of potential glutamate precursors to elucidate 1) the metabolic pathway by which gliomas make the glutamate that ..
  3. Using PET isotopes to identify drug targets and to diagnose infectious diseases
    Peter J Tonge; Fiscal Year: 2010
    ..This method relies on the incorporation of short-lived radioisotopes that decay to emit body-penetrating photons, and thus the reagents that are developed should also be useful for directly detecting pathogens in infected patients. ..
  4. Malaria and the safety of iron interventions: absorption and NTBI
    Gary M Brittenham; Fiscal Year: 2012
    ..absorption of iron from iron supplements and other iron interventions, using erythrocyte incorporation of stable:isotopes of iron; (3) to assess the effects of acute uncomplicated falciparum malaria on Iron metabolism by repeated ..
  5. TSQ Vantage Bundle with Acquity UltraPerformance LC
    Nicolaas E Deutz; Fiscal Year: 2010
    ..Citrulline and the amino-acid stable isotopes are powerful metabolic tracers, able to report on health status as it applies to a number of public health issues...
  6. Children's Exposure to Flame Retardants: Effects on Thyroid Hormone Regulation
    Heather M Stapleton; Fiscal Year: 2012
    ..levels and DI activity using liquid chromatography tandem mass spectrometry (LC/MS-MS), which will use stable isotopes instead of radio-labeled isotopes used in more traditional methods...
  7. TERPENE CONDENSATION REACTIONS
    CHARLES POULTER; Fiscal Year: 2009
    ..also synthesizing substrates, putative products, and inhibitors, including molecules with stable or radioactive isotopes, for our mechanistic studies...
  8. VitaminA and Sickle Cell Disease:Improving Suboptimal Status with Supplementation
    KELLY ANN DOUGHERTY; Fiscal Year: 2013
    ..training will include advanced formal coursework in research design, biostatistics, research ethics and stable isotopes. This training is crucial to build upon the foundations of nutrition and SCD research knowledge that she obtained ..
  9. Hyperpolarized 129-Xenon-based MRI Probes for Brain Injury
    JEREMY PHILLIP CELVER; Fiscal Year: 2010
    ..PET and SPECT have very poor spatial resolution (mm-cm) and use probes containing short-lived radioactive isotopes which emit tissue damaging ionizing radiation...
  10. Gestational Stress and Impaired Iron Homeostasis in the Young Infant
    Christopher L Coe; Fiscal Year: 2013
    ..quantify placental transfer and bioavailability of iron in the neonate, an innovative approach with stable iron isotopes will be employed, contrasting absorption and transfer of 57Fe provided orally to 58Fe infused intravenously into ..
  11. Aging and Myocardial Progenitor Recruitment
    Richard T Lee; Fiscal Year: 2013
    ..to be monitored over a wide range of times because a labeling pulse is generated using stable, nonradioactive isotopes that are non-toxic for animals and humans...
  12. Matrix Metalloproteinase Inhibitors in Stroke
    GARY ALLEN ROSENBERG; Fiscal Year: 2010
    ..Those with the ability to block the BBB will be tested in vivo with isotopes. When several candidate drugs are identified, MRI will be used to simulate the clinical conditions with ..
  13. Endogenous Oxalate Synthesis
    Ross P Holmes; Fiscal Year: 2013
    ..The use of 13C-isotopes and the quantification of 13C-labelled oxalate, glycolate and glyoxal with ion chromatography coupled to mass ..
  14. Intellectual and Development Disabilities Research Center
    Marc Yudkoff; Fiscal Year: 2013
    ..measurements of biogenic amines and amino acids in brain tissues;(iii) mass spectrometry assays of stable isotopes for kinetic studies of metabolite turnover in both whole brain and in vitro systems;(iv) a Proteomics Sub-core ..
  15. Fatty acid sources of fructose and HFCS-induced postprandial hypertriglyceridemia
    Jean Marc Schwarz; Fiscal Year: 2013
    ..Stable isotopes will be administered (via oral consumption and 26-h intravenous infusions) to subsets of subjects during the 24-h ..
  16. Beta Camera and Laparoscopic Probe for Surgical Cancer Removal.
    FARHAD DAGHIGHIAN; Fiscal Year: 2010
    ..Beta ray detectors, in conjunction with beta emitting isotopes are ideal for detection of occult tumors on the margin since background radiation would not interfere with ..
  17. Intralumental Effect on Cholesterol Absorption/Synthesis
    James Heubi; Fiscal Year: 2009
    ..Techniques employed for human studies will include state-of-the art techniques utilizing stable isotopes and isotope ratio mass spectrometry, gas chromatography...
  18. Barrier Insulators in Erythropoiesis
    Patrick G Gallagher; Fiscal Year: 2013
    ..This approach combines protein labeling by stable isotopes in vivo, integrated mass spectrometry and computational platforms, followed by validation studies...
  19. Characterizing RNA-metal binding by Raman spectroscopy
    Paul R Carey; Fiscal Year: 2012
    ..For example, for HDV crystals we label active site G1and U-1 groups with 13C and 15N isotopes to allow us to follow these residues as catalytic parameters such as pH and Mg concentration are changed...
  20. Cyclotron for PET Radiopharmaceuticals
    Jogeshwar Mukherjee; Fiscal Year: 2013
    ..It is unable to provide any significant amounts of other short-lived isotopes apart from fluorine-18...
  21. CHILDHOOD METABOLIC MARKERS OF ADULT MORBIDITY IN BLACKS
    Silva Arslanian; Fiscal Year: 2009
    ..SMLC;intralipid infusion to elevate circulating FFA levels;the hyperinsulinemiceuglycemic clamp with stable isotopes and indirect calorimetry to measure insulin sensitivity and substrate turnover;the hyperglycemic clamp to assess ..
  22. NATIONAL RESOURCE FOR IMAGING MASS SPECTROMETRY
    Claude P Lechene; Fiscal Year: 2012
    ..level, to simultaneously image the distribution and measure the accumulation of molecules labeled with any isotopes, in particular with stable isotopes, for example 15N...
  23. EXERCISE AND FUEL METABOLISM
    David H Wasserman; Fiscal Year: 2013
    ..a new, highly innovative, and comprehensive method for measurement of nutrient fluxes in the liver using stable isotopes of glucose, water, and proprionate...
  24. Enhancing Dietary Iron and Zinc Bioavailability in Indian Children
    Steven A Abrams; Fiscal Year: 2010
    ..There is no recommended daily intake for zinc in India. With stable isotopes of iron and zinc it is now possible to measure precisely iron and zinc absorption...
  25. P450-Mediated Dehydrogenation Mechanisms
    Garold S Yost; Fiscal Year: 2013
    ..of dehydrogenation by evaluating the dehydrogenation of three prototype substrates, with the use of stable isotopes and identification of protein adducts;3) to utilize integrated quantum mechanics-based models of substrates and ..
  26. Cell fate and tissue turnover in the aged studied with multi-isotope imaging mass
    Claude P Lechene; Fiscal Year: 2010
    ..method will permit to track stable-isotope labeled cells and to measure the number of cell divisions using stable-isotopes. We will use Multi-Isotope Imaging Mass Spectrometry (MIMS), a novel methodology that we have developed, MIMS has ..
  27. Fast multiplexed point-of-care diabetes autoantibody detection by homogeneous FRE
    Andrew M Arsham; Fiscal Year: 2013
    ..and require long wait times, extensive laboratory equipment, specially trained technicians, and often radioactive isotopes. The EOSCAPE-T1D is an enclosed cartridge point of care diagnostic adapted from the applicant organization's ..
  28. CELLULAR MECHANISMS OF INSULIN RESISTANCE IN HUMANS
    Gerald I Shulman; Fiscal Year: 2013
    ..13C/31P magnetic resonance spectroscopic and magnetic resonance imaging methods in combination with stable isotopes and GC and LC tandem mass spectrometry...
  29. Molecular imaging and system dynamics of tumor virotherapy
    DAVID J DINGLI; Fiscal Year: 2013
    ..Infected tumor cells express NIS and concentrate radioactive isotopes that can be imaged with single photon emission computerized tomography enabling us to serially and non- ..
  30. EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITY
    ROBERT O apos MARA RYAN; Fiscal Year: 2010
    ..A novel strategy, termed expressed protein ligation, will be employed to introduce stable isotopes into a specific, predetermined, region of apoE that is essential for LDLR binding...
  31. Quantitative Measurement of Isotope Ratios by TOF-SIMS MS
    Marvin L Vestal; Fiscal Year: 2012
    ..new multi-stage time-of-flight mass spectrometer that provides accurate measurement of the relative abundance of isotopes at very low levels...
  32. Stable isotope-based fate mapping to quantify adipogenesis in obesity
    MATTHEW STEINHAUSER; Fiscal Year: 2013
    ..Rare stable isotopes differ in mass from more common isotopic forms of elements, but they are not radioactive, and thus are entirely ..
  33. Molecular imaging of cell-based therapeutics using an engineered human enzyme.
    Arnon Lavie; Fiscal Year: 2013
    ..The signal measured in PET comes from radioactive isotopes, such a fluorine-18, that undergoes positron emission...
  34. Dietary factors in the pathogenesis of steatohepatitis
    Jacquelyn J Maher; Fiscal Year: 2013
    ..fatty acids will be individually traced through several metabolic pathways in vivo by labeling with unique stable isotopes. Specific Aim 2 will explore the cellular events by which DNL leads to hepatocyte death...
  35. EFFECT OF APOLIPOPROTEIN STRUCTURAL ADAPTABILITY
    ROBERT O apos MARA RYAN; Fiscal Year: 2013
    ..A novel strategy, termed expressed protein ligation, will be employed to introduce stable isotopes into a specific, predetermined, region of apoE that is essential for LDLR binding...
  36. DEVELOPMENT OF VESICULAR ACETYLCHOLINE TRANSPORTER IMAGING AGENTS FOR PET
    Zhude Tu; Fiscal Year: 2010
    ..different substituted group such as F, Br, I and others in order to identify a position to be labeled with PET isotopes such as carbon-11 or fluorine-18...
  37. Improved scintillators for time-of-flight positron emission tomography
    STEPHEN E DERENZO; Fiscal Year: 2013
    ..This would allow these machines to produce 3D images of positron-emitting isotopes in the human body of higher quality and with lower radiation dose...
  38. Molecular Imaging for Macrophage-Associated Pulmonary Inflammation
    Sanjay Jain; Fiscal Year: 2013
    ..targeting translocator protein (TSPO) in activated macrophages;c) can be labeled with different radioiodine isotopes (PET or SPECT) with short or long half-lives;d) excellent pharmacokinetic profile in lung tissues and;e) ..
  39. New Methods for the Expedited Synthesis of C11 and F18 PET Tracers
    Salvatore D Lepore; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Compounds labeled with positron-emitting isotopes 18F and 11C have found powerful applications as tracers for positron emission tomography (PET)...
  40. Radiolabeled RGD Peptides for Breast Cancer Imaging and Therapy
    Zhen Cheng; Fiscal Year: 2010
    ..The same ligands labeled with therapeutic isotopes will allow targeted internal radiotherapy of integrin positive tumors.
  41. Development of PET radioligands for cerebral cannabinoid receptor (CB1)
    Andrew G Horti; Fiscal Year: 2011
    ..In the R21 phase these CB1 ligands will be radiolabeled with PET isotopes and tested for their PET imaging properties in baboon...
  42. Cardiomyocyte Lineage and Turnover by Metabolic Fate-Mapping
    Richard T Lee; Fiscal Year: 2013
    ..Thus, we have developed an entirely new approach to fate-mapping using isotopes in a cell-specific metabolic precursor...
  43. High Performance, Low Cost PET Scintillators
    Kanai S Shah; Fiscal Year: 2013
    ..The availability of short-lived positron-emitting isotopes of carbon, nitrogen, oxygen and especially fluorine allows virtually any compound of biological interest to be ..
  44. X-irradiator for in vivo and in vitro studies with relevance to basic stress sign
    Albert J Fornace; Fiscal Year: 2010
    ..concern for isotope source irradiators as discussed in detail in the Advisory Committee on the Medical Uses of Isotopes's Report (NRC 2008-0184), and the long term solution, as outlined in this report, is to replace isotope ..
  45. Laser spectroscopic instrumentation for isotopic sensing of biogenic Nitric Oxide
    Gerard Wysocki; Fiscal Year: 2012
    ..1-sec time resolution, capability of selective measurements of NO isotopes, no sample preparation, and high immunity to interferences from other molecular species in a single, compact, ..
  46. Ontogeny of sociality in a mouse model
    Jeffrey R Alberts; Fiscal Year: 2012
    ..Novel "olfactory isotopes" will be used to discover the developmental determinants that derive from specific experiences in the nest with ..
  47. PET Enabled Microspheres for Radioembolization of Liver Tumors
    YONGREN BENJAMIN PENG; Fiscal Year: 2012
    ..Microspheres with just PET isotopes (i.e...
  48. INTEGRATED PROTOCOL FOR TREATMENT OF MAM AND SAM IN HUMANITARIAN EMERGENCIES
    MARK JOHN MANARY; Fiscal Year: 2013
    ..Effectiveness of breastfeeding counseling will be assessed by quantification of breast milk intake with stable isotopes. An operational validation trial will be carried out in Chad to test the integrated approach to treatment of MAM ..
  49. Thermo Electron DELTA V Advantage Isotope Ratio Mass Spectrometer
    William W Wong; Fiscal Year: 2010
    ..is the most advanced isotope ratio mass spectrometer system for the measurements of stable hydrogen and oxygen isotopes. These isotopes are the backbone of the doubly labeled water (DLW) method which is considered by the research ..
  50. Novel Cutaneous Radiation Injury Countermeasures
    Louis D Falo; Fiscal Year: 2010
    ..cutaneous injury is a major component of fission bomb/dirty bomb dispersal of beta and gamma irradiation emitting isotopes. Radiological dispersion device (RDD) "dirty bomb" events are associated with both thermal burn and radiation ..
  51. A Compact and Low Cost High-Precision Carbon Isotope Ratio Monitoring Tool for Ro
    Nabil Saad; Fiscal Year: 2009
    ..coupling a low-cost isotopic CRDS analyzer to a compact Gas Chromatography- Combustion system to measure carbon isotopes of carbon dioxide as the combustion product of individual organic compounds...
  52. Inveon: A Triple Modality Biomedical Imaging System
    Anna Liisa Brownell; Fiscal Year: 2010
    ..By using PET and SPECT imaging together, one probe can be radio labeled with two isotopes: one for PET and another for SPECT...
  53. Mayo Clinic Metabolomics Resource Core
    K Sreekumaran Nair; Fiscal Year: 2013
    ..Our services include large scale and targeted metabolomic profiling and measurement of stable isotopes in multiple metabolites, in an integrated fashion that allows us to track changes in metabolite concentration and ..
  54. A novel laser-based spectrophotometer for real-time analysis of doubly labeled wa
    DOUGLAS STEVEN BAER; Fiscal Year: 2010
    ..The Water Isotope Analyzer will be capable of real-time monitoring of oxygen and hydrogen isotopes in human and animal biological samples (blood, urine, saliva) directly and without distillation...
  55. Joint Segmentation of MR and CT scans for Gynecologic Cancer Brachytherapy
    Tina Kapur; Fiscal Year: 2012
    DESCRIPTION (provided by applicant): The placement of radioactive isotopes directly into a cancer of the uterine cervix or vagina in order to eradicate the cancer, requires insertion of a hollow applicator into the tumor...
  56. scVEGF Targeted Radiotherapy of Mammary and Colonic Cancer
    FRANCIS GERARD BLANKENBERG; Fiscal Year: 2010
    ..We propose a new strategy which leverages the ability of scVEGF linked to isotopes to target tumor vessels and kill malignant cells directly...
  57. Catalytic Domain Dynamics in Protein Kinases
    Ranajeet Ghose; Fiscal Year: 2013
    ..of sufficient quantities of soluble, properly folded protein for economically viable labeling with NMR-active isotopes. We have through a choice of optimal constructs, co-expression with chaperones and optimization of the ..
  58. Targeted Molecular Nano-Irradiation Against a Malignant Glioma Biomarker
    Akiva Mintz; Fiscal Year: 2010
    ..Despite the ultra short reach, Auger emitting isotopes have a very high linear energy transfer (LET) coefficient, which is why they produce predominantly double ..
  59. GCx(py)GCC-IRMS for Isotope Metabolomics
    JAMES T BRENNA; Fiscal Year: 2013
    ..Molecular and intramolecular isotopes, the subject of isotopic metabolomics, are natural biomarkers of molecular precursors, and of physiological state ..
  60. Mapping of Electron Tunneling Pathway in Proteins
    David Beratan; Fiscal Year: 2010
    ..Surprising rate dependencies on protein structure, docking mode, and solvent isotopes have been reported, and these observations are not anticipated by the simple static theoretical models...
  61. NMR Imaging and Spectroscopy
    Kamil Ugurbil; Fiscal Year: 2011
    ..perfusion, increased chemical-shift resolution for improved detection of neurochemicals, and the use of magnetic isotopes of biologically active atoms, such as O-17, which are not accessible easily at low magnetic fields due to their ..
  62. University of New Mexico Center for Molecular Discovery
    Larry A Sklar; Fiscal Year: 2013
    ..We are uniquely positioned to integrate imaging agents and isotopes into the MLPCN. We intend to innovate in all of our activities...
  63. A finger-prick medical diagnostic for vitamin B12 malabsorption: An early interv
    STEPHEN DUEKER; Fiscal Year: 2006
    ..of the tracer B12 by Accelerator Mass Spectrometry, a tool that achieves zeptomole (10-21) sensitivity towards C isotopes, 14 the lowest levels of any known analytical instrument...
  64. MOLECULAR BASIS OF HIV LIPODYSTROPHY: ROLE OF VPR
    Ashok Balasubramanyam; Fiscal Year: 2003
    ..Specific Aims are: a) measurements of body composition and lipid, protein and glucose metabolism, using stable isotopes/mass spectrometry, in transgenic mice over expressing Vpr, following dietary manipulations and protease inhibitor ..
  65. DEVELOPMENT OF RADIATION SYNOVECTOMY IN ARTHRITIS
    Clement Sledge; Fiscal Year: 1992
    ..Other isotopes and carrier systems, in various combinations, will be investigated in the animal model of antigen-induced ..
  66. ONTOGENY OF FETAL HEPATIC SERINE AND GLYCINE METABOLISM
    Michael Narkewicz; Fiscal Year: 1999
    ..The sites of the enzymatic control of fetal hepatic serine and glycine metabolism will be determined using stable isotopes in hepatocytes...
  67. Beta Camera and Laparoscopic Probe for Surgical Cancer Removal.
    FARHAD DAGHIGHIAN; Fiscal Year: 2007
    ..Gamma rays travel tens of cm in tissue, while beta rays have a range of~2mm. Beta emitting isotopes are ideal for intraoperative imaging since background radiation would not interfere with identification of ..
  68. ApoB and ApoA-I Kinetics in the ApoB-67 Mutation
    Francine Welty; Fiscal Year: 2006
    ..With stable isotopes, the applicant has shown that the lower than expected levels of apoB-100 result from decreased secretion and ..
  69. HIGH PERFORMANCE NEUTRON DETECTOR FOR PROTEIN CRYSTALLOGRAPHY
    JAROSLAW GLODO; Fiscal Year: 2007
    ..X-rays, neutrons can easily penetrate many heavy elements, but are readily absorbed or scattered by various light isotopes, like hydrogen, deuterium, or lithium...
  70. CARBON-13 MAGNETIC RESONANCE - METHODS AND THEORY
    DAVID MORRIS GRANT; Fiscal Year: 2010
    ..nuclear magnetic resonance (SSNMR) techniques in relevant biomedical problems using the C-13 and N-15 magnetic isotopes. SSNMR is becoming an increasingly important tool in almost all branches of chemistry and biology...
  71. Very-short-time diffusion MRI of hyperpolarized gases
    G Miller; Fiscal Year: 2009
    ..The non- radioactive noble-gas isotopes helium-3 (3He) and xenon-129 (129Xe) were introduced in the mid-1990s as inhaled contrast agents for MRI, and ..
  72. Self-contained X-ray Blood Irradiator
    BABU CHALAMALA; Fiscal Year: 2010
    ..Most blood irradiators in existence today are based on radioactive isotopes, mainly Cesium-137 and in some cases Cobalt- 60...
  73. PHOSPHORIMAGER
    Allan Brasier; Fiscal Year: 1993
    ..is rapidly replacing the traditional methods of autoradiography for detection and quantitation of radioactive isotopes embedded in polyacrylamide gels or immobilized onto nitrocellulose membranes...
  74. ENERGY EXPENDITURE IN BURNED PATIENTS
    Robert Wolfe; Fiscal Year: 1991
    ..The technique involves administration of water, labeled with the stable isotopes deuterium and oxygen-18...
  75. Riparian nutrients and food webs on a regulated river
    TERESA TIBBETS; Fiscal Year: 2005
    ..period and analyzed for carbon (C), nitrogen (N), phosphorus (P), and natural abundance of 13C and 15N stable isotopes. C and N stable isotopes used in concert with C/N, C/P, and N/P ratios are important tools to assess nutrient ..
  76. Liver triglyceride metabolism in NASH
    Elizabeth Parks; Fiscal Year: 2002
    ..due to the technical challenges of studying de novo lipogenesis and the limitations of using radioactive isotopes in humans...
  77. MEASUREMENT OF BORON STABLE ISOTOPES FOR CANCER THERAPY
    Morteza Janghorbani; Fiscal Year: 1993
    ..A new approach based on the use of stable isotopes of B is proposed for these purposes...
  78. Planning Grant for a Study of the Effect of Radiation o*
    Camille Ragin; Fiscal Year: 2006
    ..and women near Chernobyl were exposed to much higher than normal levels of radioiodine and other radioactive isotopes, especially cesium and strontium...
  79. Processing Ac-227 sources for lead-212 and radium-223 required by cancer research
    CHUCK SODERQUIST; Fiscal Year: 2007
    ..Also, additional amounts of the isotopes are required to support increased research on other cancers that will be undertaken as papers are published ..
  80. MECHANISM OF PI-RELATED DYSLIPIDEMIA AND ATHEROSCLEROSIS
    Daniel Rader; Fiscal Year: 2004
    ..dyslipidemia in humans using lipoprotein kinetic studies with endogenous labeling of apolipoprotein B with stable isotopes; 2) to determine the molecular mechanisms by which protease inhibitors cause dyslipidemia and may promote ..