carbon monoxide

Summary

Summary: Carbon monoxide (CO). A poisonous colorless, odorless, tasteless gas. It combines with hemoglobin to form carboxyhemoglobin, which has no oxygen carrying capacity. The resultant oxygen deprivation causes headache, dizziness, decreased pulse and respiratory rates, unconsciousness, and death. (From Merck Index, 11th ed)

Top Publications

  1. ncbi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Physiol Rev 86:583-650. 2006
  2. ncbi Standardisation of the single-breath determination of carbon monoxide uptake in the lung
    N MacIntyre
    Duke University Medical Center, Durham, NC, USA
    Eur Respir J 26:720-35. 2005
  3. ncbi Carbon monoxide-sensitive apoptotic death of erythrocytes
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Basic Clin Pharmacol Toxicol 111:348-55. 2012
  4. pmc Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
  5. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
  6. ncbi Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
    Steve Lancel
    Department of Physiology, Institut de Médecine Prédictive et de Recherche Thérapeutique Institut Fédératif de Recherche, Universite de Lille 2, Faculte de Medecine, Lille, France
    J Pharmacol Exp Ther 329:641-8. 2009
  7. pmc Regulation of tomato lateral root development by carbon monoxide and involvement in auxin and nitric oxide
    Kai Guo
    Department of Biochemistry and Molecular Biology, College of Life Science, Weigang No 1, Outside the Zhongshan Men, Building of Life Science, College of Life Science, Nanjing Agricultural University, Nanjing 210095, China
    J Exp Bot 59:3443-52. 2008
  8. ncbi Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
  9. ncbi Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    James E Clark
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Circ Res 93:e2-8. 2003
  10. ncbi The effect of menthol containing cigarettes on adult smokers' exposure to nicotine and carbon monoxide
    Jingzhu Wang
    Altria Client Services Inc, Center for Research and Technology, 601 E Jackson Street, Richmond, VA 23219, USA
    Regul Toxicol Pharmacol 57:24-30. 2010

Detail Information

Publications398 found, 100 shown here

  1. ncbi Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA
    Physiol Rev 86:583-650. 2006
    ..e., biliverdin and bilirubin) and thus constitute a major intracellular source of iron and carbon monoxide (CO)...
  2. ncbi Standardisation of the single-breath determination of carbon monoxide uptake in the lung
    N MacIntyre
    Duke University Medical Center, Durham, NC, USA
    Eur Respir J 26:720-35. 2005
  3. ncbi Carbon monoxide-sensitive apoptotic death of erythrocytes
    Elisabeth Lang
    Department of Physiology, University of Tubingen, Tubingen, Germany
    Basic Clin Pharmacol Toxicol 111:348-55. 2012
    b>Carbon monoxide (CO) intoxication severely interferes with the oxygen-transporting function of haemoglobin. Beyond that, CO participates in the regulation of apoptosis...
  4. pmc Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis
    Nancy Chou Macgarvey
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    Am J Respir Crit Care Med 185:851-61. 2012
    ....
  5. ncbi Heme oxygenase-1 and carbon monoxide suppress the pathogenesis of experimental cerebral malaria
    Ana Pamplona
    Instituto Gulbenkian de Ciencia, 2780 156 Oeiras, Portugal
    Nat Med 13:703-10. 2007
    ..Pharmacological induction of HO-1 and exposure to the end-product of HO-1 activity, carbon monoxide (CO), reduced ECM incidence in C57BL/6 mice to 10% and 0%, respectively...
  6. ncbi Carbon monoxide rescues mice from lethal sepsis by supporting mitochondrial energetic metabolism and activating mitochondrial biogenesis
    Steve Lancel
    Department of Physiology, Institut de Médecine Prédictive et de Recherche Thérapeutique Institut Fédératif de Recherche, Universite de Lille 2, Faculte de Medecine, Lille, France
    J Pharmacol Exp Ther 329:641-8. 2009
    Use of metal carbonyl-based compounds capable of releasing carbon monoxide (CO) in biological systems have emerged as a potential adjunctive therapy for sepsis via their antioxidant, anti-inflammatory, and antiapoptotic effects...
  7. pmc Regulation of tomato lateral root development by carbon monoxide and involvement in auxin and nitric oxide
    Kai Guo
    Department of Biochemistry and Molecular Biology, College of Life Science, Weigang No 1, Outside the Zhongshan Men, Building of Life Science, College of Life Science, Nanjing Agricultural University, Nanjing 210095, China
    J Exp Bot 59:3443-52. 2008
    b>Carbon monoxide (CO) is an endogenous gaseous molecule in organisms. Despite its reputation as a lethal gas, recent studies have shown that it is one of the most essential cellular components regulating a variety of biological processes...
  8. ncbi Heme oxygenase-1: unleashing the protective properties of heme
    Leo E Otterbein
    Division of Pulmonary and Critical Care Medicine, Montifiore University Hospital, University of Pittsburgh School of Medicine, 3459 5th Avenue, Pittsburgh, PA 15213, USA
    Trends Immunol 24:449-55. 2003
    Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein)...
  9. ncbi Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    James E Clark
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Circ Res 93:e2-8. 2003
    b>Carbon monoxide, which is generated in mammals during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator...
  10. ncbi The effect of menthol containing cigarettes on adult smokers' exposure to nicotine and carbon monoxide
    Jingzhu Wang
    Altria Client Services Inc, Center for Research and Technology, 601 E Jackson Street, Richmond, VA 23219, USA
    Regul Toxicol Pharmacol 57:24-30. 2010
    ..There is limited information comparing biomarkers of exposure (BOE) to cigarette smoke in menthol (MS) and non-menthol cigarette smokers (NMS)...
  11. pmc Heme oxygenase-1/carbon monoxide: from metabolism to molecular therapy
    Stefan W Ryter
    Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 41:251-60. 2009
    ..HO activity cleaves heme to form biliverdin-IXalpha, carbon monoxide (CO), and iron...
  12. ncbi Haem oxygenase (HO): an overlooked enzyme of plant metabolism and defence
    G S Shekhawat
    Department of Bioscience and Biotechnology, Banasthali University, Banasthali 304022, Rajasthan, India
    J Exp Bot 61:2255-70. 2010
    ..released from haem proteins with the generation of ferrous iron (Fe2+), biliverdin-IXalpha (BV-IXalpha), and carbon monoxide (CO)...
  13. ncbi CORM-A1: a new pharmacologically active carbon monoxide-releasing molecule
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    FASEB J 19:284-6. 2005
    b>Carbon monoxide (CO) is emerging as an important and versatile mediator of physiological processes to the extent that treatment of animals with exogenous CO gas has beneficial effects in a range of vascular- and inflammatory-related ..
  14. ncbi Carbon monoxide-releasing molecules: characterization of biochemical and vascular activities
    Roberto Motterlini
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex, UK
    Circ Res 90:E17-24. 2002
    b>Carbon monoxide (CO) is generated in living organisms during the degradation of heme by the enzyme heme oxygenase, which exists in constitutive (HO-2 and HO-3) and inducible (HO-1) isoforms...
  15. ncbi Biochemical characterization and ligand binding properties of neuroglobin, a novel member of the globin family
    S DeWilde
    Department of Biochemistry, University of Antwerp, B 2610 Antwerp, Belgium
    J Biol Chem 276:38949-55. 2001
    ..The biochemical and kinetic characteristics are discussed in view of the possible functions of neuroglobin in the vertebrate brain...
  16. ncbi Carbon monoxide: endogenous production, physiological functions, and pharmacological applications
    Lingyun Wu
    Department of Biology, Lakehead University, 955 Oliver Rd, Thunder Bay, Ontario, Canada P7B 5E1
    Pharmacol Rev 57:585-630. 2005
    ..the last decade, studies have unraveled many aspects of endogenous production and physiological functions of carbon monoxide (CO). The majority of endogenous CO is produced in a reaction catalyzed by the enzyme heme oxygenase (HO)...
  17. ncbi Heme oxygenase and carbon monoxide initiate homeostatic signaling
    Martin Bilban
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA
    J Mol Med (Berl) 86:267-79. 2008
    b>Carbon monoxide (CO), a gaseous second messenger, arises in biological systems during the oxidative catabolism of heme by the heme oxygenase (HO) enzymes...
  18. pmc Carbon monoxide improves cardiac function and mitochondrial population quality in a mouse model of metabolic syndrome
    Steve Lancel
    EA4484, Physiology Department, Lille 2 University, Lille, France
    PLoS ONE 7:e41836. 2012
    Metabolic syndrome induces cardiac dysfunction associated with mitochondria abnormalities. As low levels of carbon monoxide (CO) may improve myocardial and mitochondrial activities, we tested whether a CO-releasing molecule (CORM-3) ..
  19. ncbi Mechanisms of cell protection by heme oxygenase-1
    Raffaella Gozzelino
    Instituto Gulbenkian de Ciencia, Oeiras, Portugal
    Annu Rev Pharmacol Toxicol 50:323-54. 2010
    ..HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe(2+), carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death...
  20. pmc Detection of formate, rather than carbon monoxide, as the stoichiometric coproduct in conversion of fatty aldehydes to alkanes by a cyanobacterial aldehyde decarbonylase
    Douglas M Warui
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States
    J Am Chem Soc 133:3316-9. 2011
    ..We tested for and failed to detect carbon monoxide (CO), the proposed C1-derived coproduct of alkane synthesis, following the in vitro conversion of octadecanal ..
  21. ncbi Carbon monoxide: mechanisms of action and potential clinical implications
    Luc Rochette
    Laboratoire de Physiopathologie et Pharmacologies Cardio Métaboliques LPPCM, Inserm UMR866, Universite de Bourgogne, Facultes de Medecine et de Pharmacie, 7 Boulevard Jeanne d Arc, 21033 Dijon Cedex, France
    Pharmacol Ther 137:133-52. 2013
    Small amounts of carbon monoxide (CO) are continuously produced in mammals...
  22. ncbi Carbon monoxide in biology and medicine
    Stefan W Ryter
    Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, The University of Pittsburgh School of Medicine, PA, USA
    Bioessays 26:270-80. 2004
    b>Carbon monoxide (CO), a product of organic oxidation processes, arises in vivo during cellular metabolism, most notably heme degradation. CO binds to the heme iron of most hemoproteins...
  23. pmc Carbon monoxide modulates apoptosis by reinforcing oxidative metabolism in astrocytes: role of Bcl-2
    Ana S Almeida
    Instituto de Biologia Experimental e Tecnologica, Apartado 12, 2781 901 Oeiras, Portugal
    J Biol Chem 287:10761-70. 2012
    ..Because carbon monoxide (CO) is known to prevent cerebral cell death; herein the role of CO in the modulation of astrocytic ..
  24. ncbi Differential antibacterial activity against Pseudomonas aeruginosa by carbon monoxide-releasing molecules
    Mathieu Desmard
    Universite Paris Est, Creteil, France
    Antioxid Redox Signal 16:153-63. 2012
    b>Carbon monoxide (CO) delivered in a controlled manner to cells and organisms mediates a variety of pharmacological effects to the extent that CO-releasing molecules (CO-RMs) are being developed for therapeutic purposes...
  25. pmc Carbon monoxide-activated Nrf2 pathway leads to protection against permanent focal cerebral ischemia
    Bing Wang
    Center for Translational Research in Neurodegenerative Disease, University of Florida, 1275 Center Dr, Biomed Sci J493, PO 100159, Gainesville, FL 32610, USA
    Stroke 42:2605-10. 2011
    b>Carbon monoxide (CO) is a gaseous second messenger produced when heme oxygenase enzymes catabolize heme...
  26. ncbi A carbon monoxide-releasing molecule (CORM-3) uncouples mitochondrial respiration and modulates the production of reactive oxygen species
    Luisa Lo Iacono
    Department of Drug Discovery and Development, Italian Institute of Technology, 16163 Genoa, Italy
    Free Radic Biol Med 50:1556-64. 2011
    b>Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, is an important signaling mediator in mammalian cells...
  27. ncbi Higher nicotine and carbon monoxide levels in menthol cigarette smokers with and without schizophrenia
    Jill M Williams
    UMDNJ Robert Wood Johnson Medical School and UMDNJ School of Public Health Tobacco Dependence Program, New Brunswick, NJ 08901, USA
    Nicotine Tob Res 9:873-81. 2007
    ..Expired carbon monoxide (CO) and serum nicotine and cotinine were measured in 89 smokers with schizophrenia and 53 control smokers ..
  28. pmc Carbon monoxide differentially inhibits TLR signaling pathways by regulating ROS-induced trafficking of TLRs to lipid rafts
    Kiichi Nakahira
    Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA
    J Exp Med 203:2377-89. 2006
    b>Carbon monoxide (CO), a byproduct of heme catabolism by heme oxygenase (HO), confers potent antiinflammatory effects...
  29. pmc Carbon monoxide-releasing molecules (CO-RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages
    Philip Sawle
    Department of Surgical Research, Vascular Biology Unit, Northwick Park Institute for Medical Research, Harrow, Middlesex
    Br J Pharmacol 145:800-10. 2005
    ..and anti-inflammatory protein that degrades heme to produce biliverdin/bilirubin, ferrous iron and carbon monoxide (CO)...
  30. ncbi Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury
    Julia Biermann
    University Eye Hospital Freiburg, University Medical Center, Killianstrasse 5, 79106 Freiburg, Germany
    Invest Ophthalmol Vis Sci 51:3784-91. 2010
    PURPOSE. Retinal ischemia/reperfusion (I/R) injury damages retinal neurons. Carbon monoxide (CO) recently attracted attention as cytoprotective because of its anti-inflammatory and antiapoptotic effects...
  31. ncbi Suppression of inflammatory cytokine production by carbon monoxide involves the JNK pathway and AP-1
    Danielle Morse
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 278:36993-8. 2003
    ..For the first time, the effect of CO is shown to be mediated via the JNK signaling pathway and the transcription factor AP-1...
  32. ncbi A new activating role for CO in cardiac mitochondrial biogenesis
    Hagit B Suliman
    Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Sci 120:299-308. 2007
    To investigate a possible new physiological role of carbon monoxide (CO), an endogenous gas involved in cell signaling and cytotoxicity, we tested the hypothesis that the mitochondrial generation of reactive oxygen species by CO ..
  33. ncbi Mitochondrial respiratory chain and NAD(P)H oxidase are targets for the antiproliferative effect of carbon monoxide in human airway smooth muscle
    Camille Taillé
    INSERM Unité 700 and Unité 683, Institut Federatif de Recherche 02, Faculte de Medecine Xavier Bichat, 75018 Paris, France
    J Biol Chem 280:25350-60. 2005
    b>Carbon monoxide (CO), one of the end products of heme oxygenase activity, inhibits smooth muscle proliferation by decreasing ERK1/2 phosphorylation and cyclin D1 expression, a signaling pathway that is known to be modulated by reactive ..
  34. ncbi Watching a protein as it functions with 150-ps time-resolved x-ray crystallography
    Friedrich Schotte
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA
    Science 300:1944-7. 2003
    ....
  35. ncbi Activation of PPAR-gamma by carbon monoxide from CORM-2 leads to the inhibition of iNOS but not COX-2 expression in LPS-stimulated macrophages
    Konstantin Tsoyi
    Department of Pharmacology, School of Medicine and Institute of Life Sciences, Biomedical Center BK21, Gyeongsang National University, Jinju 660 751, Korea
    Inflammation 32:364-71. 2009
    ....
  36. pmc Exogenous carbon monoxide attenuates inflammatory responses in the small intestine of septic mice
    Xu Wang
    Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang 212001, Jiangsu Province, China
    World J Gastroenterol 18:5719-28. 2012
    To determine whether the carbon monoxide (CO)-releasing molecules (CORM)-liberated CO suppress inflammatory responses in the small intestine of septic mice.
  37. ncbi The therapeutic potential of carbon monoxide
    Roberto Motterlini
    Drug Discovery and Development, Italian Institute of Technology, Via Morego 30, Genoa, Italy
    Nat Rev Drug Discov 9:728-43. 2010
    b>Carbon monoxide (CO) is increasingly being accepted as a cytoprotective and homeostatic molecule with important signalling capabilities in physiological and pathophysiological situations...
  38. ncbi Inhaled carbon monoxide increases retinal and choroidal blood flow in healthy humans
    Hemma Resch
    Medical University of Vienna corrected
    Invest Ophthalmol Vis Sci 46:4275-80. 2005
    It has been hypothesized that carbon monoxide (CO) acts as an important vascular paracrine factor and plays a role in blood flow regulation in several tissues...
  39. ncbi Carbon monoxide protects against the development of experimental necrotizing enterocolitis
    Brian S Zuckerbraun
    Dept of Surgery, Children s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
    Am J Physiol Gastrointest Liver Physiol 289:G607-13. 2005
    ..b>Carbon monoxide (CO), a byproduct of the catabolism of heme, is known to have anti-inflammatory and antiapoptotic properties...
  40. pmc Imaging the migration pathways for O2, CO, NO, and Xe inside myoglobin
    Jordi Cohen
    Department of Physics and Beckman Institute, University of Illinois, Urbana, Illinois, USA
    Biophys J 91:1844-57. 2006
    ..We also compare the pathway maps of Mb for different gas ligands and for different animal species...
  41. ncbi Developing drug molecules for therapy with carbon monoxide
    Carlos C Romão
    Alfama Lda, Taguspark, núcleo central 267, 2740 122 Porto Salvo, Portugal
    Chem Soc Rev 41:3571-83. 2012
    The use of Carbon Monoxide (CO) as a therapeutic agent has already been tested in human clinical trials. Pre-clinically, CO gas administration proved beneficial in animal models of various human diseases...
  42. pmc Effect of heme oxygenase–endogenous carbon monoxide on mortality during septic shock in rats
    J B Yu
    Department of Anesthesiology, Tianjin Nankai Hospital, China
    Ir J Med Sci 178:491-6. 2009
    ..To investigate the effect of HO–CO on mortality during septic shock in rats...
  43. pmc Carbon monoxide induces hypothermia tolerance in Kupffer cells and attenuates liver ischemia/reperfusion injury in rats
    Lung Yi Lee
    Thomas E Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA
    Liver Transpl 17:1457-66. 2011
    ..We examined whether a pretreatment with carbon monoxide (CO), a cytoprotective product of heme degradation, could influence KC activity during cold storage and ..
  44. pmc Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway
    Takayuki Morikawa
    Department of Biochemistry, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 109:1293-8. 2012
    ..Thus, in intact adult brain cerebral cortex of HO-2-null mice, imaging mass spectrometry reveals an impaired ability to maintain ATP levels on hypoxia...
  45. pmc The social network of carbon monoxide in medicine
    Barbara Wegiel
    Transplant Institute, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Trends Mol Med 19:3-11. 2013
    ..enzyme heme oxygenase-1 (HO-1) generates three separate signaling molecules through the catalysis of heme - carbon monoxide (CO), biliverdin, and iron - each of which acts via distinct molecular targets to influence cell function, ..
  46. ncbi Kinetic effects of carbon monoxide inhalation on tissue protection in ventilator-induced lung injury
    Simone Faller
    Department of Anesthesiology and Critical Care Medicine, University Medical Center Freiburg, Germany
    Lab Invest 92:999-1012. 2012
    ..b>Carbon monoxide (CO) can confer lung protective effects during mechanical ventilation...
  47. pmc The heme oxygenase/carbon monoxide system is involved in the auxin-induced cucumber adventitious rooting process
    Wei Xuan
    College of Life Sciences, Cooperative Demonstration Laboratory of Centrifuge Technique, Nanjing Agricultural University, Nanjing, China
    Plant Physiol 148:881-93. 2008
    ..In animals, carbon monoxide (CO), mainly generated by heme oxygenases (HOs), is a significant modulator of inflammatory reactions, ..
  48. ncbi Water-soluble CO-releasing molecules reduce the development of postoperative ileus via modulation of MAPK/HO-1 signalling and reduction of oxidative stress
    O De Backer
    Heymans Institute of Pharmacology, Faculty of Medicine, Ghent University, Ghent, Belgium
    Gut 58:347-56. 2009
    Treatment with carbon monoxide (CO) inhalation has been shown to ameliorate postoperative ileus (POI) in rodents and swine...
  49. ncbi Carbon monoxide inhibition of apoptosis during ischemia-reperfusion lung injury is dependent on the p38 mitogen-activated protein kinase pathway and involves caspase 3
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 278:1248-58. 2003
    b>Carbon monoxide (CO), a reaction product of the cytoprotective gene heme oxygenase, has been shown to be protective against organ injury in a variety of models...
  50. ncbi Carbon monoxide-releasing molecules modulate leukocyte-endothelial interactions under flow
    Paula Urquhart
    William Harvey Research Institute, London, UK
    J Pharmacol Exp Ther 321:656-62. 2007
    b>Carbon monoxide (CO) generated by the enzyme heme oxygenase during the breakdown of heme is known to mediate a number of biological effects...
  51. pmc Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation
    Charles W Leffler
    Dept of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    J Appl Physiol (1985) 100:1065-76. 2006
    ..Both the HO-CO and CSE-H2S systems have potential to interact with NO and prostanoids in the cerebral circulation. Much of the physiology and biochemistry of HO-CO and CSE-H2S in the cerebral circulation remains open for exploration...
  52. pmc The diesel exhaust in miners study: I. Overview of the exposure assessment process
    Patricia A Stewart
    Division of Cancer Epidemiology and Genetics, US National Cancer Institute, Bethesda, MD 20892, USA
    Ann Occup Hyg 54:728-46. 2010
    ..based on job titles, on the amount of time spent in various areas of the underground mine, and on similar carbon monoxide (CO, another DE component) concentrations] and to surface jobs (based on the use of, or proximity to, diesel-..
  53. pmc Carbon monoxide, skeletal muscle oxidative stress, and mitochondrial biogenesis in humans
    Michael A Rhodes
    Department of Anesthesiology, Duke University Medical Center, Durham, NC 27710, USA
    Am J Physiol Heart Circ Physiol 297:H392-9. 2009
    ..heme oxygenase-1 (HO-1) encompasses mitochondrial biogenesis, we tested the hypothesis that the HO-1 product, carbon monoxide (CO), activates mitochondrial biogenesis in skeletal muscle and enhances maximal oxygen uptake (Vo(2max)) in ..
  54. pmc Ligand migration through the internal hydrophobic cavities in human neuroglobin
    Stefania Abbruzzetti
    Dipartimento di Fisica, National Enterprise for nanoScience and nanoTechnology CNR INFM, Universita degli Studi di Parma, 43100 Parma, Italy
    Proc Natl Acad Sci U S A 106:18984-9. 2009
    ..Overall, data are consistent with the presence of a discrete system of docking sites, possibly acting as reservoirs for the putative cosubstrates and for other reactive species involved in the physiologically relevant reaction...
  55. ncbi Intraoperative administration of inhaled carbon monoxide reduces delayed graft function in kidney allografts in Swine
    D W Hanto
    Harvard Medical School, the Transplant Institute and the Department of Surgery, Division of Transplantation at Beth Israel Deaconess Medical Center, Boston, MA, USA
    Am J Transplant 10:2421-30. 2010
    ..We developed a pig kidney allograft model of DGF and evaluated the cytoprotective effects of inhaled carbon monoxide (CO)...
  56. pmc Carbon monoxide activates autophagy via mitochondrial reactive oxygen species formation
    Seon Jin Lee
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
    Am J Respir Cell Mol Biol 45:867-73. 2011
    ..b>Carbon monoxide (CO), a toxic gas and candidate therapeutic molecule, confers cytoprotection in animal models of acute lung ..
  57. ncbi Exploring the antimicrobial action of a carbon monoxide-releasing compound through whole-genome transcription profiling of Escherichia coli
    Lígia S Nobre
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Avenida da Republica EAN, 2780 157 Oeiras, Portugal
    Microbiology 155:813-24. 2009
    We recently reported that carbon monoxide (CO) has bactericidal activity...
  58. ncbi After vascular injury, heme oxygenase-1/carbon monoxide enhances re-endothelialization via promoting mobilization of circulating endothelial progenitor cells
    H H Lin
    Institute of Pharmacology, School of Medicine, National Yang Ming University, Taipei, Taiwan
    J Thromb Haemost 7:1401-8. 2009
    ..Heme oxygenase-1 (HO-1), a heme degradation enzyme with multiple vasoprotective functions, is systemically induced in pathophysiological states associated with oxidative stress...
  59. pmc HO-1 and CO decrease platelet-derived growth factor-induced vascular smooth muscle cell migration via inhibition of Nox1
    Andres I Rodriguez
    Department of Surgery, University of Pittsburgh School of Medicine, 3501 5 Ave, BST3 Room 6058, Pittsburgh, PA 15261, USA
    Arterioscler Thromb Vasc Biol 30:98-104. 2010
    ..Results and Methods- The effects of increased HO-1 expression, as well as biliverdin, bilirubin, and carbon monoxide (CO), were studied in in vitro models of VSMC migration...
  60. ncbi Pre-conditioning induced by carbon monoxide provides neuronal protection against apoptosis
    Helena L A Vieira
    Instituto de Biologia Experimental e Tecnologica, Oeiras, Portugal
    J Neurochem 107:375-84. 2008
    b>Carbon monoxide (CO) is an endogenous product of mammalian cells generated by heme-oxygenase, presenting anti-apoptotic properties in several tissues...
  61. pmc Antimicrobial action of carbon monoxide-releasing compounds
    Lígia S Nobre
    Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Avenida da Republica EAN, 2781 901 Oeiras, Portugal
    Antimicrob Agents Chemother 51:4303-7. 2007
    b>Carbon monoxide (CO) is endogenously produced in the human body, mainly from the oxidation of heme catalyzed by heme oxygenase (HO) enzymes...
  62. pmc Hypoxia activates a Ca2+-permeable cation conductance sensitive to carbon monoxide and to GsMTx-4 in human and mouse sickle erythrocytes
    David H Vandorpe
    Molecular and Vascular Medicine Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 5:e8732. 2010
    ..Deoxygenation-induced currents sharing some properties of Psickle have been recorded from sickle erythrocytes in whole cell configuration...
  63. ncbi CORM-3-derived CO modulates polymorphonuclear leukocyte migration across the vascular endothelium by reducing levels of cell surface-bound elastase
    Shinjiro Mizuguchi
    Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, Canada N6A 4G4
    Am J Physiol Heart Circ Physiol 297:H920-9. 2009
    Recently, it has been shown that carbon monoxide (CO)-releasing molecule (CORM)-released CO can suppress inflammation...
  64. ncbi Direct placental effects of cigarette smoke protect women from pre-eclampsia: the specific roles of carbon monoxide and antioxidant systems in the placenta
    Shannon A Bainbridge
    Department of Anatomy and Cell Biology, Faculty of Health Sciences, Botterell Hall, Queen s University, Kingston, Ont, Canada K7L 3N6
    Med Hypotheses 64:17-27. 2005
    ..These various mechanisms of action must be further examined as they may provide valuable keys to novel therapeutic design in the realm of pre-eclampsia research...
  65. ncbi Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation--a tale of three gases!
    Ling Li
    Pharmaceutical Science Division, King s College London, Franklin Wilkins Building, 150 Stamford Street, London SE19NH, UK
    Pharmacol Ther 123:386-400. 2009
    Nitric oxide (NO), carbon monoxide (CO) and hydrogen sulphide (H(2)S) together make up a family of biologically active gases (the so-called 'gaseous triumvirate') with an increasingly well defined range of physiological effects plus ..
  66. pmc Carbon monoxide inhibits L-type Ca2+ channels via redox modulation of key cysteine residues by mitochondrial reactive oxygen species
    Jason L Scragg
    Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health, and Therapeutics, Level 10, Worsley Bldg, University of Leeds, Leeds LS2 9JT, United Kingdom
    J Biol Chem 283:24412-9. 2008
    ..This in turn leads to redox modulation of any or all of three critical cysteine residues in the channel's cytoplasmic C-terminal tail, resulting in channel inhibition...
  67. ncbi Therapeutic applications of the gaseous mediators carbon monoxide and hydrogen sulfide
    Gerard L Bannenberg
    Campus de la Universidad Autonoma, Centro Nacional de Biotecnologia CSIC, Department of Plant Molecular Genetics, Madrid, Spain
    Expert Opin Ther Pat 19:663-82. 2009
    Hydrogen sulfide (H(2)S) and carbon monoxide (CO) are endogenously produced gaseous autacoids that regulate a number of physiological processes, including the inflammatory response, cell death and proliferation, neural transmission and ..
  68. ncbi Inhibition of cellular respiration by endogenously produced carbon monoxide
    Gabriela D'Amico
    Wolfson Institute for Biomedical Research, University College London, UK
    J Cell Sci 119:2291-8. 2006
    ..Exogenous carbon monoxide (CO) is also known to inhibit cytochrome c oxidase in vitro; however, it is not clear whether endogenously ..
  69. ncbi Breath carbon monoxide as an indication of smoking habit
    E T Middleton
    University of Sheffield, UK
    Chest 117:758-63. 2000
    To assess whether the breath carbon monoxide (CO) concentration can be used to determine a patient's smoking habits in a respiratory outpatient clinic.
  70. pmc Interactions of multiple gas-transducing systems: hallmarks and uncertainties of CO, NO, and H2S gas biology
    Mayumi Kajimura
    Department of Biochemistry and Integrative Medical Biology, School of Medicine, Keio University, Tokyo, Japan
    Antioxid Redox Signal 13:157-92. 2010
    ..By evaluating gas-mediated control functions from both in vitro and in vivo perspectives, we hope to elaborate on the complex multiple interactions of O2, NO, CO, and H2S...
  71. ncbi Heme oxygenase-1-derived carbon monoxide requires the activation of transcription factor NF-kappa B to protect endothelial cells from tumor necrosis factor-alpha-mediated apoptosis
    Sophie Brouard
    Immunobiology Research Center, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 277:17950-61. 2002
    We have shown that carbon monoxide (CO) generated by heme oxygenase-1 (HO-1) protects endothelial cells (EC) from tumor necrosis alpha (TNF-alpha)-mediated apoptosis. This effect relies on the activation of p38 MAPK...
  72. pmc Haem oxygenase delays programmed cell death in wheat aleurone layers by modulation of hydrogen peroxide metabolism
    Mingzhu Wu
    College of Life Sciences, Co Laboratory of Nanjing Agricultural University and Carl Zeiss Far East, Jiangsu Province, Nanjing Agricultural University, Nanjing 210095, PR China
    J Exp Bot 62:235-48. 2011
    ..The application of the HO-1 inducer, haematin, and the enzymatic reaction product of HO, carbon monoxide (CO) aqueous solution, both of which brought about a noticeable induction of HO expression, substantially ..
  73. pmc Nox4 NADPH oxidase-derived reactive oxygen species, via endogenous carbon monoxide, promote survival of brain endothelial cells during TNF-α-induced apoptosis
    Shyamali Basuroy
    Dept of Physiology, University of Tennessee Health Science Center, 894 Union Ave, Memphis, TN 38163, USA
    Am J Physiol Cell Physiol 300:C256-65. 2011
    ..ROS also initiate a cell survival mechanism by increasing production of a gaseous antioxidant mediator carbon monoxide (CO) by constitutive heme oxygenase-2 (HO-2)...
  74. ncbi Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress
    Ki Mo Kim
    Department of Immunology, Wonkwang University School of Medicine, Iksan, Chunbug 570 749, Republic of Korea
    Circ Res 101:919-27. 2007
    b>Carbon monoxide (CO), a reaction product of the cytoprotective heme oxygenase (HO)-1, is antiapoptotic in a variety of models of cellular injury, but the precise mechanisms remain to be established...
  75. ncbi Polycyclic aromatic hydrocarbons, carbon monoxide, "tar", and nicotine in the mainstream smoke aerosol of the narghile water pipe
    Alan Shihadeh
    Aerosol Research Laboratory, Department of Mechanical Engineering, American University of Beirut, PO Box 11 0236, Riad El Solh, Beirut, Lebanon
    Food Chem Toxicol 43:655-61. 2005
    ..The results indicate that narghile smoke likely contains an abundance of several of the chemicals thought to be causal factors in the elevated incidence of cancer, cardiovascular disease and addiction in cigarette smokers...
  76. ncbi The heme oxygenase-carbon monoxide system: regulation and role in stress response and organ failure
    Michael Bauer
    Department of Anesthesiology and Intensive Care Medicine, Friedrich Schiller University Hospital, Erlanger Allee 101, 07740, Jena, Germany
    Intensive Care Med 34:640-8. 2008
    ..the iron-containing, oxygen-carrying constituent of red blood cells, yielding biliverdin, iron (II) ions, and carbon monoxide (CO)...
  77. ncbi Amelioration of rat cardiac cold ischemia/reperfusion injury with inhaled hydrogen or carbon monoxide, or both
    Atsunori Nakao
    Department of Surgery, Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittburgh, Pennsylvania 15213, USA
    J Heart Lung Transplant 29:544-53. 2010
    Recent advances in novel medical gases, including hydrogen and carbon monoxide (CO), have demonstrated significant opportunities for therapeutic use...
  78. pmc Carbon monoxide, reactive oxygen signaling, and oxidative stress
    Claude A Piantadosi
    Department of Medicine, Duke University Medical Center, Box 3315 CR II Building White Zone, Trent Drive, Durham, NC 27710, USA
    Free Radic Biol Med 45:562-9. 2008
    The ubiquitous gas, carbon monoxide (CO), is of substantial biological importance, but apart from its affinity for reduced transition metals, particularly heme-iron, it is surprisingly nonreactive-as is the ferrous-carbonyl-in living ..
  79. ncbi Carbon monoxide protects against hyperoxia-induced endothelial cell apoptosis by inhibiting reactive oxygen species formation
    Xue Wang
    Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania 15213, USA
    J Biol Chem 282:1718-26. 2007
    ..Likewise, carbon monoxide, at low concentrations, markedly inhibited hyperoxia-induced endothelial cell death by inhibiting cytochrome ..
  80. ncbi Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
    Leo E Otterbein
    Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pittsburgh School of Medicine, Montefiore University Hospital, Pittsburgh, Pennsylvania, USA
    Nat Med 9:183-90. 2003
    b>Carbon monoxide (CO), one of the products of heme oxygenase action on heme, prevents arteriosclerotic lesions that occur following aorta transplantation; pre-exposure to 250 parts per million of CO for 1 hour before injury suppresses ..
  81. ncbi Carbon monoxide orchestrates a protective response through PPARgamma
    Martin Bilban
    Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 24:601-10. 2006
    b>Carbon monoxide (CO) suppresses proinflammatory responses in macrophages reacting to LPS. We hypothesize that CO acts by inducing a molecule(s) that suppresses the inflammatory response to subsequent stress...
  82. pmc Carbon monoxide induces cytoprotection in rat orthotopic lung transplantation via anti-inflammatory and anti-apoptotic effects
    Ruiping Song
    Division of Pulmonary, Allergy and Critical Care Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    Am J Pathol 163:231-42. 2003
    ..is mounting evidence that the stress response gene heme oxygenase-1 (HO-1) and/or its catalytic by-product carbon monoxide (CO) confers cytoprotection against tissue and cellular injury...
  83. pmc Carbon monoxide ameliorates chronic murine colitis through a heme oxygenase 1-dependent pathway
    Refaat A F Hegazi
    Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA
    J Exp Med 202:1703-13. 2005
    Heme oxygenase (HO)-1 and its metabolic product carbon monoxide (CO) play regulatory roles in acute inflammatory states...
  84. pmc Mycobacterium tuberculosis senses host-derived carbon monoxide during macrophage infection
    Michael U Shiloh
    Department of Medicine, Division of Infectious Diseases, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell Host Microbe 3:323-30. 2008
    ..stimulates expression of heme oxygenase (HO-1) by macrophages and that the gaseous product of this enzyme, carbon monoxide (CO), activates expression of the dormancy regulon...
  85. pmc Heme oxygenase-1-derived carbon monoxide enhances the host defense response to microbial sepsis in mice
    Su Wol Chung
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Invest 118:239-47. 2008
    ..These data advocate HO-1-derived CO as an important mediator of the host defense response to sepsis and suggest CO administration as a possible treatment for the disease...
  86. ncbi Personal child and mother carbon monoxide exposures and kitchen levels: methods and results from a randomized trial of woodfired chimney cookstoves in Guatemala (RESPIRE)
    Kirk R Smith
    Environmental Health Sciences, School of Public Health, University of California, Berkeley, California 94720 7360, USA
    J Expo Sci Environ Epidemiol 20:406-16. 2010
    ..Pollution Indoors and Respiratory Effects) in air pollution epidemiology, we pioneered application of passive carbon monoxide (CO) diffusion tubes to measure long-term personal exposures to woodsmoke...
  87. ncbi Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators
    Kelly S Davidge
    Department of Molecular Biology and Biotechnology, The University of Sheffield, Firth Ct, Western Bank, Sheffield S10 2TN, United Kingdom
    J Biol Chem 284:4516-24. 2009
    b>Carbon monoxide, a classical respiratory inhibitor, also exerts vasodilatory, anti-inflammatory, and antiapoptotic effects. CO-releasing molecules have therapeutic value, increasing phagocytosis and reducing sepsis-induced lethality...
  88. ncbi Role of CO-releasing molecules liberated CO in attenuating leukocytes sequestration and inflammatory responses in the lung of thermally injured mice
    Bingwei Sun
    Department of Burns and Plastic Surgery, Affiliated Hospital, Jiangsu University, Zhenjiang, Jiangsu Province, People s Republic of China
    J Surg Res 139:128-35. 2007
    ..In this study, we used CO-releasing molecules (CORM-2) to determine whether the CO-releasing molecules-liberated CO could attenuate leukocytes sequestration and the inflammatory response in the lung of thermally injured mice...
  89. ncbi Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 280:8714-21. 2005
    b>Carbon monoxide (CO), previously considered a toxic waste product of heme catabolism, is emerging as an important gaseous molecule...
  90. pmc Glutathionylation of adenine nucleotide translocase induced by carbon monoxide prevents mitochondrial membrane permeabilization and apoptosis
    Cláudia S F Queiroga
    Instituto de Biologia Experimental e Tecnologica, Apartado 12, 2781 901 Oeiras, Portugal
    J Biol Chem 285:17077-88. 2010
    ..In conclusion, CO protects astrocytes from apoptosis by preventing MMP, acting on ANT (glutathionylation and inhibition of its pore activity) via a preconditioning-like process mediated by ROS and GSSG...
  91. pmc Low doses of carbon monoxide protect against experimental focal brain ischemia
    Emil Zeynalov
    Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 365, Baltimore, MD 21205, USA
    Neurotox Res 15:133-7. 2009
    b>Carbon monoxide (CO) is associated with central nervous system toxicity. However, evidence also indicates that CO can be protective, depending on its concentration...
  92. ncbi Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury
    Xuchen Zhang
    Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Biol Chem 278:22061-70. 2003
    b>Carbon monoxide is protective in ischemia-reperfusion organ injury, but the precise mechanisms remain elusive...
  93. pmc Heme oxygenase-1-derived carbon monoxide induces the Mycobacterium tuberculosis dormancy regulon
    Ashwani Kumar
    Department of Microbiology, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    J Biol Chem 283:18032-9. 2008
    ..We have demonstrated previously that O(2), nitric oxide (NO), and carbon monoxide (CO) are regulatory ligands of DosS and DosT...
  94. pmc A novel carbon monoxide-releasing molecule fully protects mice from severe malaria
    Ana C Pena
    Unidade de Imunologia Molecular, Instituto de Medicina Molecular, Universidade de Lisboa, Lisbon, Portugal
    Antimicrob Agents Chemother 56:1281-90. 2012
    ..Herein, we report the design and synthesis of a novel carbon monoxide-releasing molecule (CO-RM; ALF492) that fully protects mice against experimental CM (ECM) and ALI...
  95. pmc Immunomodulatory effects of inhaled carbon monoxide on rat syngeneic small bowel graft motility
    A Nakao
    Thomas E Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA
    Gut 52:1278-85. 2003
    ..Therefore, we tested the protective effects of inhaled carbon monoxide (CO) and an endogenous haeme oxygenase 1 (HO-1) anti-inflammatory mediator on transplant induced inflammatory ..
  96. ncbi Toward quantitative simulations of carbon monoxide escape pathways in myoglobin
    Ron Elber
    Department of Chemistry and Biochemistry, and Institute of Computational Sciences and Engineering, University of Texas at Austin, 1 University Station, ICES, C0200, Austin, Texas 78712, USA
    J Phys Chem B 112:6147-54. 2008
    Straightforward molecular dynamics trajectories have been computed to explore the diffusion of carbon monoxide through myoglobin. The classical equations of motion were integrated for 2 ns and the resulting pathways analyzed...
  97. ncbi Peroxynitrite mediates disruption of Ca2+ homeostasis by carbon monoxide via Ca2+ ATPase degradation
    Nishani T Hettiarachchi
    Leeds Institute of Genetics, Health and Therapeutics, Faculties of Medicine and Health, University of Leeds, United Kingdom
    Antioxid Redox Signal 17:744-55. 2012
    Sublethal carbon monoxide poisoning causes prolonged neurological damage involving oxidative stress...
  98. pmc Assessing recent smoking status by measuring exhaled carbon monoxide levels
    Annsofi Sandberg
    Science for Life Laboratory, Department of Oncology Pathology, Karolinska Institutet, Stockholm, Sweden
    PLoS ONE 6:e28864. 2011
    ..Our aim was to extend the use of exhaled carbon monoxide (CO(breath)), a well-established method for separating smokers from non-smokers, to assessment of recent ..
  99. ncbi Carbon monoxide liberated from carbon monoxide-releasing molecule CORM-2 attenuates inflammation in the liver of septic mice
    Gediminas Cepinskas
    Centre for Critical Illness Research, Lawson Health Research Institute, London, Ontario, N6A 4G4, Canada
    Am J Physiol Gastrointest Liver Physiol 294:G184-91. 2008
    ....
  100. ncbi Carbon monoxide, generated by heme oxygenase-1, mediates the enhanced permeability and retention effect in solid tumors
    Jun Fang
    Laboratory of Microbiology and Oncology, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan
    Cancer Sci 103:535-41. 2012
    ..Almost no extravasation was detected when inactivated HO-1 or a carbon monoxide (CO) scavenger was injected instead...
  101. pmc Genomic analysis of carbon monoxide utilization and butanol production by Clostridium carboxidivorans strain P7
    Guillaume Bruant
    Biotechnology Research Institute, National Research Council of Canada, Montreal, Quebec, Canada
    PLoS ONE 5:e13033. 2010
    ..This study has generated in depth knowledge of the P7(T) genome, which will be helpful in developing metabolic engineering strategies to improve C. carboxidivorans's natural capacity to produce potential biofuels from syngas...

Research Grants68

  1. Polycyclic aromatic hydrocarbons and birth outcomes in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2013
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to the exact locations of participants'homes...
  2. Comparison of Diesel and Biodiesel Emissions and Health Effects in Underground Mi
    Jefferey L Burgess; Fiscal Year: 2013
    ..Respirable dust, elemental carbon, black carbon, nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO), aldehydes, and polycyclic aromatic hydrocarbons (PAHs) will be sampled from the mine...
  3. Nicotinic Acetylcholine Receptor Density and Veteran Cigarette Smokers
    Arthur Brody; Fiscal Year: 2013
    ..that menthol cigarette smoking leads to elevated serum levels of nicotine and cotinine, and greater exhaled carbon monoxide levels...
  4. Regulatory Oxygenases in Vasculopathic Rickettsioses
    SANJEEV SAHNI; Fiscal Year: 2010
    ..an enzyme responsible for the degradation of pro-oxidant heme into biologically active molecules (bilirubin, carbon monoxide, and ferritin) with diverse cytoprotective functions;2...
  5. Rheologic and Vascular Modulators in Sickle Vaso-occlusion
    Dhananjay K Kaul; Fiscal Year: 2012
    ..will be dependent not only on tissue oxygen tension, but also on nitric oxide (NO) bioavailability, carbon monoxide (CO) generation and increased oxidative stress (reperfusion injury)...
  6. Mechanisms for Cardiovascular Effects of air pollutants: Effect of Age and Sex
    BRITT HOLMEN; Fiscal Year: 2010
    ..and emission testing has shown that biodiesel emissions appear to contain reduced levels of hydrocarbons, carbon monoxide and particulate matter (PM) but a higher soluble organic fraction in the particulate phase...
  7. Human Heme Oxygenase-1 Gene Regulation in Renal Injury
    Anupam Agarwal; Fiscal Year: 2012
    ..due to the anti-oxidant, anti-inflammatory and anti-apoptotic effects of its reaction products, namely carbon monoxide and biliverdin/bilirubin...
  8. Air Pollution, Inflammation and Preterm Birth: A Mechanistic Study in Mexico City
    MARIE SYLVIA O'NEILL; Fiscal Year: 2012
    ..5, PM10, ozone, nitrogen dioxide, sulfur dioxide, carbon monoxide), matched to locations of participants'homes...
  9. Heme Oxygenase Enzymes/Carbon Monoxide in Hepatic Dysfunction from hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..Our investigations have focused on the understanding of the role of carbon monoxide (CO) in physiological and pathophysiological conditions, as well as the development of CO as a therapeutic...
  10. BIOENGINEERING DESIGN OF ARTIFICIAL BLOOD
    Marcos Intaglietta; Fiscal Year: 2011
    ..this present application we will test the hypothesis that MP4 is an effective carrier of the heme ligands O2, carbon monoxide (CO)and nitric oxide (NO), and will carry out the related physiological studies in order to understand its ..
  11. Role of Microbial Translocation in Cardiopulmonary Disease in Children with HIV
    Alison Morris; Fiscal Year: 2013
    ..hypertension on echocardiography, increased airway obstruction, impairment of diffusing capacity for carbon monoxide, and more rapid progression of pulmonary abnormalities...
  12. Redox Regulation of Lung Mitochondrial Biogenesis in Sepsis/Pneumonia
    Claude A Piantadosi; Fiscal Year: 2013
    ..network of mitochondrial biogenesis, which is strongly activated by the induction of the heme oxygenase-1/carbon monoxide system (HO-1/CO) to protect energy metabolism and mitochondrial mass, but which we think may also promote the ..
  13. Statins for Pulmonary and Cardiac Complications of Chronic HIV (The SPARC Trial)
    Stephen R Wisniewski; Fiscal Year: 2013
    ..individuals who received statin therapy within the past year tended to have better diffusing capacity for carbon monoxide, less airway obstruction, lower pulmonary artery pressures and cardiac strain, lower peripheral cytokines, ..
  14. Brain Nicotine Receptor Density &Response to Nicotine Patch
    Arthur Brody; Fiscal Year: 2013
    ..be assessed at each weekly treatment visit and at the end of treatment using participant reports, exhaled carbon monoxide levels, and urinary cotinine levels...
  15. Mechanisms that Regulate Neonatal Lung Heme Oxygenase in Hyperoxia
    Phyllis A Dennery; Fiscal Year: 2013
    ..is degraded to generate equimolar quantities of biologically active products such as iron, biliverdin, and carbon monoxide (CO) possibly accounting for the cytoprotective effects attributed to HO-1...
  16. Rev-ERBa Regulates Mitochondrial Biogenesis, Adiposity, and Insulin Action
    Thomas H Reynolds; Fiscal Year: 2010
    ..Rev-ERBa's binding site, but increases heme oxygenase-1 (HO-1), our hypothesis is that the HO-1 product, carbon monoxide, inhibits Rev-ERBa...
  17. Cookstove Replacement for Prevention of ARI and Low Birthweight in Nepal
    JAMES MACK TIELSCH; Fiscal Year: 2012
    ..the risk of these infections and low birthweight by reducing the exposure to airborne fine particles and carbon monoxide caused by the open burning of biomass fuel sources in the home by replacing the cookstoves with an improved, ..
  18. Hypertension, Kidney and Pregnancy
    Joey P Granger; Fiscal Year: 2013
    ..we propose that induction of the stress response gene, hemeoxygenase-1 (HO-1), and its catalytic products, carbon monoxide (CO) and bilirubin, may provide a novel therapeutic approach for the treatment of PE...
  19. Heme Oxygenase Polymorphisms and Hepatopulmonary Syndrome
    KARI EVAN ROBERTS; Fiscal Year: 2012
    ..Recent evidence from animal and human HPS implicates abnormal heme oxygenase and carbon monoxide signaling in the disease process...
  20. Blood Pressure Regulation: Novel Roles for the Kidney
    Pablo A Ortiz; Fiscal Year: 2013
    ..Project 3 will test whether heme oxygenases in the macula densa produce carbon monoxide (CO) and biliverdin, which act synergistically and in an autocrine manner to inhibit tubuloglomeailar ..
  21. Effect of Smoking on Adult Stem Cell Differentiation
    Herman S Cheung; Fiscal Year: 2013
    ..Significant tissue hypoxia mainly attributed to carbon monoxide (CO) and nicotine...
  22. HEMOPROTEIN OXIDATION AND HEME CATABOLISM
    Paul R Ortiz de Montellano; Fiscal Year: 2013
    DESCRIPTION (provided by applicant): Heme oxygenases (HOs) oxidize heme to biliverdin, iron, and carbon monoxide (CO) via a complex, three-stage process that requires seven electrons and three molecules of O2...
  23. Socioeconomic status and smoking exposure in Appalachia
    Joshua E Muscat; Fiscal Year: 2013
    ..whether SES is associated with biomarkers of smoking exposure including salivary cotinine and expired carbon monoxide. This addresses the SES hypothesis using biological measures of dose in addition to environmental measures ..
  24. Waterpipe tobacco smoke: toxicant exposure and effects
    THOMAS EVAN EISSENBERG; Fiscal Year: 2012
    ..S. These deaths are caused by inhaled smoke toxicants like carcinogens, carbon monoxide (CO), and nitric oxide (NO). Another smoke toxicant, nicotine, produces dependence with prolonged use...
  25. Novel Strategies to Increase Insulin Independence after Islet Autotransplantation
    Hongjun Wang; Fiscal Year: 2013
    ..induction of a protective gene, heme oxygenase-1 (HO-1), or exposing the product of HO-1 enzymatic activity, carbon monoxide (CO), protects islet allografts from immune rejection after transplantation...
  26. Endogenous Gas Molecules As Transcription Factors
    Leo E Otterbein; Fiscal Year: 2012
    ..More recently in 1998, a second functional gas molecule was revealed;carbon monoxide, touted as a toxin to avoid, was shown to be a biologically active gas molecule with potent cytoprotective ..
  27. Impact of an Indoor Stove Intervention on Indicators of Cardiorespiratory Health
    Jennifer L Peel; Fiscal Year: 2012
    ..symptoms);(3) Compare air pollution concentrations of indoor fine particulate matter and indoor and personal carbon monoxide at baseline and Year 2 (among a subsample of the population), and evaluate the relationship of change in ..
  28. Biomarkers of Exposure to and Health Effects from SHS in Outdoor Smoking Areas
    Luke P Naeher; Fiscal Year: 2011
    ..Preliminary work has shown significant positive correlations between particulate matter (PM2.5) and/or carbon monoxide (CO) and number of smokers outside establishments, significant increases in salivary cotinine, and measurable ..
  29. IVR Technology to Mobilize Contingency Management for Smoking Cessation
    SHEILA MARIE ALESSI; Fiscal Year: 2012
    ..Expired carbon monoxide (CO) is the most common objective smoking status test used in smoking research and treatment...
  30. The Mycobacterium Tuberculosis Dormancy Program
    MARTIN INUA VOSKUIL; Fiscal Year: 2013
    ..three factors limit Mtb aerobic respiration: the inhibitory effect of macrophage-produced nitric oxide and carbon monoxide, and the structure of mature granulomas...
  31. Maternal and Child Health Benefits from Reducing Household Air Pollution
    Patricia L Hibberd; Fiscal Year: 2013
    ..5 micrometers, carbon monoxide and biomarkers 1-hydroxypyrene, methoxyphenol and cotinine (tobacco smoke)...
  32. The Role of Heme Oxygenase-1 in the Immune Response
    James F George; Fiscal Year: 2013
    ..HO-1) system consists of the enzyme heme oxygenase-1 and the products of the degradation of heme, carbon monoxide, biliverdin, and iron...
  33. Gastrointestinal Smooth Muscle in Health &Disease
    Joseph H Szurszewski; Fiscal Year: 2012
    ..H2S, the effect of H2S on smooth muscle membrane potential and the physiological interplay between H2S and carbon monoxide, the cellular and molecular mechanisms(s) that mediate the hyperpolarizing response to H2S in circular smooth ..
  34. BIOINORGANIC COPPER COORDINATION CHEMISTRY
    Kenneth D Karlin; Fiscal Year: 2013
    ..into the fundamentally important O-O cleavage process will be carried out, (2) the study of O2 and carbon monoxide (CO, as O2-surrogate) kinetics and thermodynamics of binding to tetradentate ligand CuI-chelates including ..
  35. Carbon Monoxide Therapy to Prevent Circulatory Collapse and Shock From Hemorrhage
    BRIAN SCOTT ZUCKERBRAUN; Fiscal Year: 2013
    ..Our investigations have focused on the understanding of the role of carbon monoxide (CO) in physiological and pathophysiological conditions, as well as the development of CO as a therapeutic...
  36. Intervening to Improve Birth Weight and Infant Respiratory Health in Rural Ghana
    PATRICK LOTT KINNEY; Fiscal Year: 2013
    ..We will assess real-time personal exposure to carbon monoxide (CO) among all subjects during pregnancy and during the neonatal period...
  37. Molecular Mechanisms in Retinal Degeneration
    Debora B Farber; Fiscal Year: 2011
    ..of membrane and soluble guanylate cyclases (GC), the effects of GC-activating proteins, nitric oxide and carbon monoxide;the participation of rod, cone and Ca2+/calmodulin-dependent PDEs, and the role of guanine deaminase, which ..
  38. Better Understanding of the Neuroprotective Mechanisms of Korean Ginseng in Strok
    SYLVAIN DORE; Fiscal Year: 2013
    ..HO, which cleaves heme (a prooxidant) to form biliverdin/bilirubin (antioxidants), carbon monoxide (a vasodilator), and iron (a prooxidant) has been shown to play a protective role in oxidative stress, ..
  39. MEDIATORS OF PULMONARY VASODILATATION IN LIVER DISEASE
    Michael B Fallon; Fiscal Year: 2013
    ..and we contributes to the progression of HPS at later time points, by producing heme oxygenase-1 derived carbon monoxide. Whether ET-1 and ETB receptor mediated effects recruit and activate macrophages in the lung is unknown...
  40. Household air pollution in Tanzania, placental health and pregnancy outcome
    BLAIR JOHNSON WYLIE; Fiscal Year: 2013
    ..cooks, are exposed to harmful pollutants released from the inefficient combustion of these fuels, notably carbon monoxide (CO) and fine particulate matter (PM2.5)...
  41. Inhibitor of differentiation-1 mediates antifibrotic effects of carbon monoxide
    ERIN DANIELLE MORSE; Fiscal Year: 2012
    ..our reported observations and preliminary studies that heme oxygenase-1 (HO-1) and its enzymatic product, carbon monoxide (CO), provide protection against bleomycin-induced lung fibrosis...
  42. CARBON MONOXIDE IN NEWBORN CEREBRAL CIRCULATION
    CHARLES LEFFLER; Fiscal Year: 2009
    The gas, carbon monoxide (CO), is produced physiologically by catabolism of heme via heme oxygenase...
  43. Mechanisms and Regulation of Inducible Nitric Oxide Synthase
    JOSEPH EDWARD SABAT; Fiscal Year: 2010
    ..Therefore, iNOS must be carefully regulated. Based on preliminary studies, carbon monoxide, which is produced physiologically by heme-oxygenase-1 (HO), directly inhibits the activity of iNOS through a ..
  44. Carbon monoxide mediated inhibition of intimal hyperplasia
    Edith Tzeng; Fiscal Year: 2013
    ..One very promising treatment for IH that has come to the forefront recently is carbon monoxide (CO)...
  45. Enhancing the effectiveness of human cardiac stem cell therapy
    Chuanxi Cai; Fiscal Year: 2013
    ..b>Carbon monoxide (CO), a byproduct of heme oxygenase 1 (HO-1), has a potent anti- apoptotic, cytoprotective effect against ..
  46. Eicosanoids and carbon monoxide in neonatal cerebral microcirculation
    ALIE JOSEPH KANU; Fiscal Year: 2012
    ..of eicosanoids, specifically the cyclooxygenase (COX)-prostanoid system, with the heme oxygenase (HO)-carbon monoxide (CO) system in the regulation of cerebral vasodilation...
  47. MOCSLID-DCC
    Robert M Elashoff; Fiscal Year: 2012
    ..to compare MMF and CYC on the course of total lung capacity, single- breath diffusing capacity for carbon monoxide, breathlessness (Mahler Transition Dyspnea Index), several HRQoL measures (SGRQ, SF-36), functional ability (..
  48. Prenatal Exposure to Solid Fuel Smoke and Birth Outcomes in Sri Lanka
    Nalini Sathiakumar; Fiscal Year: 2011
    ..fuel combustion in inefficient cooking stoves in poorly ventilated areas causes heavy maternal exposure to carbon monoxide (CO) and to fine particulate matter (PM2.5), both known to cause fetal anoxia...
  49. Air Pollution and Children's Cognitive and Health Outcomes
    Ashlesha Datar; Fiscal Year: 2013
    ..body of literature has linked exposure to criteria pollutants (particulate matter, ground-level ozone, carbon monoxide, sulfur oxides, nitrogen oxides, and lead) with adverse health outcomes in children, however, much of this ..
  50. Mechanism of Dialysis Arteriovenous Fistula Dysfunction
    Karl A Nath; Fiscal Year: 2013
    ..This aim will determine the effects of HO products (carbon monoxide and bile pigments) on AVF pathobiology in HO-1+/+ mice, and whether these products can attenuate the ..
  51. Integrative Consequences of Hypoxia
    Nanduri R Prabhakar; Fiscal Year: 2013
    ..hypothesis that the effects of CIH on the carotid body are due to ROS-mediated imbalance between inhibitory (carbon monoxide;CO) and excitatory (hydrogen sulfide;H2S) gaseous messengers...
  52. CONTROL OF NEONATAL CIRCULATION
    Charles W Leffler; Fiscal Year: 2013
    ..b>Carbon monoxide (CO) from astrocyte heme oxygenase (HO) is important in regulation of newborn cerebral circulation and ..
  53. Breath Analysis using Quantum Cascade Lasers
    JOANNE SHORTER; Fiscal Year: 2009
    ..The presence of elevated levels of nitric oxide (NO), carbon monoxide (CO), carbonyl sulfide (OCS), and ethane (C2H6) in the breath have been identified as biomarkers of these ..
  54. Heme Oxygenase-1/Carbon Monoxide in Lung Vascular Injury
    Augustine M Choi; Fiscal Year: 2013
    ..Our laboratory and others have started to unravel the mechanisms and signaling pathways by which carbon monoxide (CO) imparts protective effects in various models of cellular and tissue injury...
  55. Impacts on Health and Mental Health post Superstorm Sandy, New Jersey
    Christina Tan; Fiscal Year: 2013
    ..We will look at all causes, with particular attention to injuries, carbon monoxide poisonings, cardiovascular events, and suicide...
  56. Phase II Study of Inhales Carbon Monoxide for the Treatment of Idiopathic Pulmona
    Ivan O Rosas; Fiscal Year: 2013
    ..Hypothesis: Inhaled low concentration carbon monoxide will slow or arrest the progression of lung fibrosis in patients with IPF...
  57. Endothelial BK Channels and Vasoreactivity Following Chronic Hypoxia
    Benjimen R Walker; Fiscal Year: 2013
    ..is due to enhanced endothelial activity of the enzyme heme oxygenase with resultant increased production of carbon monoxide (CO). CO, in turn, activates endothelial BK channels to cause hyperpolarization leading to vasodilation...
  58. NO-independent cGMP regulation of vascular remodeling
    David A Tulis; Fiscal Year: 2012
    ..Nitric oxide (NO) and carbon monoxide (CO) operate as soluble guanylate cyclase (sGC)-activating ligands for cGMP synthesis; however, limitations ..
  59. Zonisamide Augmentation of Varenicline for Smoking Cessation
    Annie Umbricht; Fiscal Year: 2013
    ..Cotinine is a sensitive indicator of smoking status with a longer half-life then carbon monoxide (CO) and is therefore more likely to detect low or intermittent smoking...
  60. Protective Role of Carbon Monoxide in Hepatic I/R Injury
    Noriko Murase; Fiscal Year: 2010
    ..b>Carbon monoxide (CO), an endogenous byproduct of heme, has lately received notable attention as a regulatory molecule in ..
  61. Heme oxygenase-1 and alcoholic liver disease
    Laura E Nagy; Fiscal Year: 2013
    ..We have recently characterized a hemeoxygenase-1 (HO-1)/carbon monoxide (CO)-dependent pathway that is profoundly effective at decreasing chronic ethanol-induced inflammatory ..
  62. Contingency Management for Smoking Cessation in Pregnant Minority Women
    Veronica H Accornero; Fiscal Year: 2013
    ..Abstinence monitoring via expired carbon monoxide and salivary continues levels will occur in both groups beginning on the first quit day and continuing ..
  63. BIOLOGICAL METAL CLUSTERS--BIOPHYSICAL AND MODEL STUDIES
    Michael Maroney; Fiscal Year: 1999
    ..Cu, Zn; nitrogenase, Mo, Fe; cytochrome oxidase, heme a3, CuB; hydrogenase, acetyl coenzyme A synthase, carbon monoxide dehydrogenase, Ni, Fe)...
  64. Air Pollution and Adverse Birth Outcomes
    Beate Ritz; Fiscal Year: 2004
    ..We recently reported that air pollution, specifically carbon monoxide (CO) and particulate matter less than 10 microns in diameter (PM10), increased the risk of giving birth to ..
  65. BIOLOGICAL METAL CLUSTERS--BIOPHYSICAL & MODEL STUDIES
    Michael Maroney; Fiscal Year: 1991
    ..These enzymes serve to oxidize molecular hydrogen (or reduce hydrogen ions) and to oxidize carbon monoxide to carbon dioxide and thus serve key roles in the bioenergetics of certain microorganisms...
  66. Heme Oxygenase and Spinal Cord Injury
    Linda Noble; Fiscal Year: 2004
    ..Heme oxygenases are the only enzymes that metabolize the pro-oxidant heme to bile pigments, iron, and carbon monoxide. Extracellular heme is derived from intraparenchymal hemorrhage and heme proteins released from dying cells...
  67. Pulse CO-Oximeter for Multiple Hemoglobin Species
    JONAS POLOGE; Fiscal Year: 2009
    ..are formed endogenously at very low levels, but their quantities can increase to dangerous levels when carbon monoxide is present in inspired air or as a reaction to certain drugs or chemicals in the environment...
  68. PORPHYRINS AND QUINONES AS ENZYME COFACTORS
    THOMAS LOEHR; Fiscal Year: 1999
    ..In these O2-dependent processes, carbon monoxide is released. HO activity found in brain tissue has implicated CO as a neurotransmitter...