water

Summary

Summary: Water. A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Top Publications

  1. ncbi Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy
    B W Caughey
    NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840
    Biochemistry 30:7672-80. 1991
  2. ncbi Root-ABA1, a major constitutive QTL, affects maize root architecture and leaf ABA concentration at different water regimes
    Silvia Giuliani
    Department of Agroenvironmental Science and Technology DISTA, University of Bologna, Viale Fanin 44, I 40127 Bologna, Italy
    J Exp Bot 56:3061-70. 2005
  3. ncbi Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging
    Hanzhang Lu
    Department of Radiology, Center of Biomedical Imaging, New York University School of Medicine, New York, NY 10016, USA
    NMR Biomed 19:236-47. 2006
  4. ncbi CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana
    Taishi Umezawa
    Gene Discovery Research Group, RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    Plant J 46:171-82. 2006
  5. ncbi The effect of drought and heat stress on reproductive processes in cereals
    Beáta Barnabás
    Agricultural Research Institute of the Hungarian Academy of Sciences, Brunszvik 2, H 2462 Martonvásár, Hungary
    Plant Cell Environ 31:11-38. 2008
  6. ncbi The basis of anisotropic water diffusion in the nervous system - a technical review
    Christian Beaulieu
    Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Canada
    NMR Biomed 15:435-55. 2002
  7. ncbi Gene networks involved in drought stress response and tolerance
    Kazuo Shinozaki
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 203 0045 Japan
    J Exp Bot 58:221-7. 2007
  8. pmc Salt and drought stress signal transduction in plants
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Plant Biol 53:247-73. 2002
  9. pmc Morris water maze: procedures for assessing spatial and related forms of learning and memory
    Charles V Vorhees
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Nat Protoc 1:848-58. 2006
  10. ncbi Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways
    K Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, 305 0074, Japan
    Curr Opin Plant Biol 3:217-23. 2000

Detail Information

Publications344 found, 100 shown here

  1. ncbi Secondary structure analysis of the scrapie-associated protein PrP 27-30 in water by infrared spectroscopy
    B W Caughey
    NIAID, National Institutes of Health, Rocky Mountain Laboratories, Hamilton, Montana 59840
    Biochemistry 30:7672-80. 1991
    ..The infrared-based secondary structure compositions were then used as constraints to improve the theoretical localization of the secondary structures within PrP-res 27-30...
  2. ncbi Root-ABA1, a major constitutive QTL, affects maize root architecture and leaf ABA concentration at different water regimes
    Silvia Giuliani
    Department of Agroenvironmental Science and Technology DISTA, University of Bologna, Viale Fanin 44, I 40127 Bologna, Italy
    J Exp Bot 56:3061-70. 2005
    ..alleles at a major QTL for leaf ABA concentration (L-ABA), were field-tested for 2 years under well-watered and water-stressed conditions...
  3. ncbi Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging
    Hanzhang Lu
    Department of Radiology, Center of Biomedical Imaging, New York University School of Medicine, New York, NY 10016, USA
    NMR Biomed 19:236-47. 2006
    Conventional diffusion tensor imaging (DTI) measures water diffusion parameters based on the assumption that the spin displacement distribution is a Gaussian function...
  4. ncbi CYP707A3, a major ABA 8'-hydroxylase involved in dehydration and rehydration response in Arabidopsis thaliana
    Taishi Umezawa
    Gene Discovery Research Group, RIKEN Plant Science Center, Yokohama, Kanagawa 230 0045, Japan
    Plant J 46:171-82. 2006
    ..Taken together, our results indicate that CYP707A3 plays an important role in determining threshold levels of ABA during dehydration and after rehydration...
  5. ncbi The effect of drought and heat stress on reproductive processes in cereals
    Beáta Barnabás
    Agricultural Research Institute of the Hungarian Academy of Sciences, Brunszvik 2, H 2462 Martonvásár, Hungary
    Plant Cell Environ 31:11-38. 2008
    ..Here we attempt to summarize the currently available information on cereal reproduction under drought and heat stress and to give an outlook towards potential strategies to improve yield safety in cereals...
  6. ncbi The basis of anisotropic water diffusion in the nervous system - a technical review
    Christian Beaulieu
    Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, Edmonton, Canada
    NMR Biomed 15:435-55. 2002
    Anisotropic water diffusion in neural fibres such as nerve, white matter in spinal cord, or white matter in brain forms the basis for the utilization of diffusion tensor imaging (DTI) to track fibre pathways...
  7. ncbi Gene networks involved in drought stress response and tolerance
    Kazuo Shinozaki
    RIKEN Plant Science Center, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, 203 0045 Japan
    J Exp Bot 58:221-7. 2007
    Plants respond to survive under water-deficit conditions via a series of physiological, cellular, and molecular processes culminating in stress tolerance...
  8. pmc Salt and drought stress signal transduction in plants
    Jian Kang Zhu
    Department of Plant Sciences, University of Arizona, Tucson, Arizona 85721, USA
    Annu Rev Plant Biol 53:247-73. 2002
    ....
  9. pmc Morris water maze: procedures for assessing spatial and related forms of learning and memory
    Charles V Vorhees
    Division of Neurology MLC 7044, Cincinnati Children s Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine, 3333 Burnet Ave, Cincinnati, OH 45229 3039, USA
    Nat Protoc 1:848-58. 2006
    The Morris water maze (MWM) is a test of spatial learning for rodents that relies on distal cues to navigate from start locations around the perimeter of an open swimming arena to locate a submerged escape platform...
  10. ncbi Molecular responses to dehydration and low temperature: differences and cross-talk between two stress signaling pathways
    K Shinozaki
    Laboratory of Plant Molecular Biology, Tsukuba Life Science Center, Institute of Physical and Chemical Research RIKEN, Tsukuba, 305 0074, Japan
    Curr Opin Plant Biol 3:217-23. 2000
    ..Recent studies are providing evidence of differences between dehydration-signaling and cold-stress-signaling cascades, and of cross-talk between them...
  11. pmc MRI quantification of non-Gaussian water diffusion by kurtosis analysis
    Jens H Jensen
    Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, New York 10016 3295, USA
    NMR Biomed 23:698-710. 2010
    Quantification of non-Gaussianity for water diffusion in brain by means of diffusional kurtosis imaging (DKI) is reviewed. Diffusional non-Gaussianity is a consequence of tissue structure that creates diffusion barriers and compartments...
  12. ncbi Reactive oxygen species homeostasis and signalling during drought and salinity stresses
    Gad Miller
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, 89557, USA
    Plant Cell Environ 33:453-67. 2010
    b>Water deficit and salinity, especially under high light intensity or in combination with other stresses, disrupt photosynthesis and increase photorespiration, altering the normal homeostasis of cells and cause an increased production of ..
  13. pmc Arabidopsis basic leucine zipper transcription factors involved in an abscisic acid-dependent signal transduction pathway under drought and high-salinity conditions
    Y Uno
    Biological Resources Division, Japan International Research Center for Agricultural Science JIRCAS, Ministry of Agriculture, Forestry, and Fisheries, Ohwashi 1 2, Tsukuba, Ibaraki 305 8686, Japan
    Proc Natl Acad Sci U S A 97:11632-7. 2000
    ..Using cultured Arabidopsis cells, we demonstrated that a specific ABA-activated protein kinase of 42-kDa phosphorylated conserved N-terminal regions in the AREB proteins...
  14. ncbi Methods and concepts in quantifying resistance to drought, salt and freezing, abiotic stresses that affect plant water status
    Paul E Verslues
    Institute for Integrative Genome Biology and Department of Botany and Plant Sciences, University of California, Riverside, CA 92521, USA
    Plant J 45:523-39. 2006
    ..stresses of drought, salinity and freezing are linked by the fact that they all decrease the availability of water to plant cells. This decreased availability of water is quantified as a decrease in water potential...
  15. pmc Escaping free-energy minima
    Alessandro Laio
    Centro Svizzero di Calcolo Scientifico, Via Cantonale, CH 6928 Manno, Switzerland
    Proc Natl Acad Sci U S A 99:12562-6. 2002
    ..We demonstrate the usefulness of this approach in the case of the dissociation of a NaCl molecule in water and in the study of the conformational changes of a dialanine in solution.
  16. pmc Arabidopsis OST1 protein kinase mediates the regulation of stomatal aperture by abscisic acid and acts upstream of reactive oxygen species production
    Anna Chiara Mustilli
    Institut des Sciences du Vegetal, Centre National de la Recherche Scientifique, Unité Propre de Recherche 2355, 91190 Gif sur Yvette, France
    Plant Cell 14:3089-99. 2002
    During drought, the plant hormone abscisic acid (ABA) triggers stomatal closure, thus reducing water loss...
  17. pmc The enigmatic LEA proteins and other hydrophilins
    Marina Battaglia
    Departamento de Biologia Molecular de Plantas, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos 62250, Mexico
    Plant Physiol 148:6-24. 2008
  18. pmc Water, sanitation and hygiene for the prevention of diarrhoea
    Sandy Cairncross
    London School of Hygiene and Tropical Medicine, Department of Infectious and Tropical Diseases, London, UK
    Int J Epidemiol 39:i193-205. 2010
    Ever since John Snow's intervention on the Broad St pump, the effect of water quality, hygiene and sanitation in preventing diarrhoea deaths has always been debated...
  19. pmc Molecular and physiological analysis of drought stress in Arabidopsis reveals early responses leading to acclimation in plant growth
    Amal Harb
    Virginia Bioinformatics Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061, USA
    Plant Physiol 154:1254-71. 2010
    ..A comparative transcriptome analysis of soil water deficit drought stress treatments revealed the similarity of early-stage mDr to progressive drought, identifying ..
  20. ncbi Regulation of drought tolerance by gene manipulation of 9-cis-epoxycarotenoid dioxygenase, a key enzyme in abscisic acid biosynthesis in Arabidopsis
    S Iuchi
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 27:325-33. 2001
    ..We improved drought tolerance by gene manipulation of AtNCED3 causing the accumulation of endogenous ABA...
  21. ncbi The ethylene response factors SNORKEL1 and SNORKEL2 allow rice to adapt to deep water
    Yoko Hattori
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    Nature 460:1026-30. 2009
    ..This discovery will contribute to rice breeding in lowland areas that are frequently flooded during the rainy season...
  22. ncbi Sub1A is an ethylene-response-factor-like gene that confers submergence tolerance to rice
    Kenong Xu
    Department of Plant Pathology, University of California, Davis, California 95616, USA
    Nature 442:705-8. 2006
    ..Cultivation of this variety is expected to provide protection against damaging floods and increase crop security for farmers...
  23. ncbi Closing yield gaps through nutrient and water management
    Nathaniel D Mueller
    Institute on the Environment, University of Minnesota, St Paul, Minnesota 55108, USA
    Nature 490:254-7. 2012
    ..Meeting the food security and sustainability challenges of the coming decades is possible, but will require considerable changes in nutrient and water management.
  24. pmc PEGylated nanographene oxide for delivery of water-insoluble cancer drugs
    Zhuang Liu
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    J Am Chem Soc 130:10876-7. 2008
    It is known that many potent, often aromatic drugs are water insoluble, which has hampered their use for disease treatment...
  25. ncbi Structural determinants of water permeation through aquaporin-1
    K Murata
    National Institute for Physiological Sciences, Okazaki, Japan
    Nature 407:599-605. 2000
    Human red cell AQP1 is the first functionally defined member of the aquaporin family of membrane water channels. Here we describe an atomic model of AQP1 at 3.8A resolution from electron crystallographic data...
  26. pmc The MYB96 transcription factor mediates abscisic acid signaling during drought stress response in Arabidopsis
    Pil Joon Seo
    Molecular Signaling Laboratory, Department of Chemistry, Seoul National University, Seoul, Korea 151 742
    Plant Physiol 151:275-89. 2009
    ..is the primary site that perceives drought stress signals, and its development is profoundly affected by soil water content...
  27. ncbi Important roles of drought- and cold-inducible genes for galactinol synthase in stress tolerance in Arabidopsis thaliana
    Teruaki Taji
    Laboratory of Plant Molecular Biology, RIKEN Tsukuba Institute, 3 1 1 Koyadai, Tsukuba, Ibaraki 305 0074, Japan
    Plant J 29:417-26. 2002
    ....
  28. pmc Water influx into cerebrospinal fluid is primarily controlled by aquaporin-4, not by aquaporin-1: 17O JJVCPE MRI study in knockout mice
    Hironaka Igarashi
    aCenter for Integrated Human Brain Science, Brain Research Institute, University of Niigata, Niigata, Japan bDepartment of Neurology, University of California, Davis, Davis, California, USA
    Neuroreport 25:39-43. 2014
    Recent studies on cerebrospinal fluid (CSF) homeostasis emphasize the importance of water flux through the pericapillary (Virchow-Robin) space for both CSF production and reabsorption (Oreskovic and Klarica hypothesis), and challenge the ..
  29. ncbi Architecture of the photosynthetic oxygen-evolving center
    Kristina N Ferreira
    Department of Biological Sciences, Imperial College London, London, SW7 2AZ, UK
    Science 303:1831-8. 2004
    Photosynthesis uses light energy to drive the oxidation of water at an oxygen-evolving catalytic site within photosystem II (PSII). We report the structure of PSII of the cyanobacterium Thermosynechococcus elongatus at 3...
  30. pmc The relationship of drought-related gene expression in Arabidopsis thaliana to hormonal and environmental factors
    Daiqing Huang
    Plant Biotechnology Institute, National Research Council of Canada, 110 Gymnasium Place, Saskatoon S7N 0W9, Canada
    J Exp Bot 59:2991-3007. 2008
    ..These analyses demonstrate that ABA-related stress responses are modulated by other environmental and developmental factors...
  31. ncbi OsDREB genes in rice, Oryza sativa L., encode transcription activators that function in drought-, high-salt- and cold-responsive gene expression
    Joseph G Dubouzet
    Biological Resources Division, Japan International Research Center for Agricultural Sciences JIRCAS, 1 1 Ohwashi, Tsukuba, Ibaraki 305 8686, Japan
    Plant J 33:751-63. 2003
    ..OsDREB1A is potentially useful for producing transgenic monocots that are tolerant to drought, high-salt, and/or cold stresses...
  32. pmc Glial-conditional deletion of aquaporin-4 (Aqp4) reduces blood-brain water uptake and confers barrier function on perivascular astrocyte endfeet
    Nadia Nabil Haj-Yasein
    Centre for Molecular Medicine Norway, Nordic EMBL Partnership, University of Oslo, 0318 Oslo, Norway
    Proc Natl Acad Sci U S A 108:17815-20. 2011
    ..deletion of the Aqp4 gene is required to differentiate between the numerous pools of aquaporin-4 (AQP4) water channels...
  33. ncbi Drought-induced responses of photosynthesis and antioxidant metabolism in higher plants
    Attipalli Ramachandra Reddy
    School of Life Sciences, Pondicherry University, Pondicherry 605 014, India
    J Plant Physiol 161:1189-202. 2004
    ..and molecular responses to drought is essential for a holistic perception of plant resistance mechanisms to water-limited conditions...
  34. ncbi Impairment of angiogenesis and cell migration by targeted aquaporin-1 gene disruption
    Samira Saadoun
    Department of Medicine, Cardiovascular Research Institute, University of California, San Francisco, San Francisco, California 94143, USA
    Nature 434:786-92. 2005
    Aquaporin-1 (AQP1) is a water channel protein expressed widely in vascular endothelia, where it increases cell membrane water permeability. The role of AQP1 in endothelial cell function is unknown...
  35. pmc Replacing caloric beverages with water or diet beverages for weight loss in adults: main results of the Choose Healthy Options Consciously Everyday (CHOICE) randomized clinical trial
    Deborah F Tate
    Department of Nutrition, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7440, USA
    Am J Clin Nutr 95:555-63. 2012
    ..Replacement of caloric beverages with noncaloric beverages may be a simple strategy for promoting modest weight reduction; however, the effectiveness of this strategy is not known...
  36. ncbi Water as an essential nutrient: the physiological basis of hydration
    E Jequier
    Department of Physiology, University of Lausanne, Pully, Switzerland
    Eur J Clin Nutr 64:115-23. 2010
    How much water we really need depends on water functions and the mechanisms of daily water balance regulation...
  37. pmc Functional analysis of an Arabidopsis transcription factor, DREB2A, involved in drought-responsive gene expression
    Yoh Sakuma
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki 305 8686, Japan
    Plant Cell 18:1292-309. 2006
    ..Microarray and RNA gel blot analyses revealed that DREB2A regulates expression of many water stress-inducible genes...
  38. ncbi The structure of the potassium channel: molecular basis of K+ conduction and selectivity
    D A Doyle
    Laboratory of Molecular Neurobiology and Biophysics and the Howard Hughes Medical Institute, Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Science 280:69-77. 1998
    ..A large water-filled cavity and helix dipoles are positioned so as to overcome electrostatic destabilization of an ion in the ..
  39. ncbi Elevated CO2 effects on plant carbon, nitrogen, and water relations: six important lessons from FACE
    Andrew D B Leakey
    1406 Institute of Genomic Biology, University of Illinois, Urbana, IL 61801, USA
    J Exp Bot 60:2859-76. 2009
    ..Second, elevated CO(2) improves nitrogen use efficiency and, third, decreases water use at both the leaf and canopy scale...
  40. pmc Prediction of water and metal binding sites and their affinities by using the Fold-X force field
    Joost W H Schymkowitz
    European Molecular Biology Laboratory, Meyerhofstrasse 1, Heidelberg D 69117, Germany
    Proc Natl Acad Sci U S A 102:10147-52. 2005
    ..Here, we present an enhanced version of the force field allowing prediction of the position of structural water molecules and metal ions, together called single atom ligands...
  41. pmc Early effects of salinity on water transport in Arabidopsis roots. Molecular and cellular features of aquaporin expression
    Yann Boursiac
    Biochimie et Physiologie Moleculaire des Plantes, Agro Montpellier Centre National de la Recherche Scientifique Institut National de la Recheche Agonomique Université Montpellier 2, Unité Mixte de Recherche 5004, France
    Plant Physiol 139:790-805. 2005
    Aquaporins facilitate the uptake of soil water and mediate the regulation of root hydraulic conductivity (Lp(r)) in response to a large variety of environmental stresses...
  42. pmc The Arabidopsis GTL1 transcription factor regulates water use efficiency and drought tolerance by modulating stomatal density via transrepression of SDD1
    Chan Yul Yoo
    Center for Plant Environmental Stress Physiology, Purdue University, West Lafayette, Indiana 47907 2010, USA
    Plant Cell 22:4128-41. 2010
    A goal of modern agriculture is to improve plant drought tolerance and production per amount of water used, referred to as water use efficiency (WUE)...
  43. ncbi Understanding regulatory networks and engineering for enhanced drought tolerance in plants
    Babu Valliyodan
    Division of Plant Sciences and National Center for Soybean Biotechnology, University of Missouri Columbia, Missouri 65211, USA
    Curr Opin Plant Biol 9:189-95. 2006
    ..Better understanding of the specific roles of various metabolites in crop stress tolerance will give rise to a strategy for the metabolic engineering of crop tolerance of drought...
  44. ncbi Directional water collection on wetted spider silk
    Yongmei Zheng
    School of Chemistry and Environment, Beijing University of Aeronautics and Astronautics, Beijing 100191, China
    Nature 463:640-3. 2010
    ..kingdom possess unusual structural features at the micro- and nanometre-scale that control their interaction with water and hence wettability...
  45. pmc Leaf maximum photosynthetic rate and venation are linked by hydraulics
    Tim J Brodribb
    Department of Plant Sciences, University of Tasmania, Hobart, Tasmania 7001, Australia
    Plant Physiol 144:1890-8. 2007
    ..Following the logic that leaf veins evolved to bypass inefficient water transport through living mesophyll tissue, we examined the hydraulic pathway beyond the distal ends of the vein ..
  46. ncbi Stable liquid water droplet on a water monolayer formed at room temperature on ionic model substrates
    Chunlei Wang
    Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, 201800, China
    Phys Rev Lett 103:137801. 2009
    Using molecular dynamics simulation, we show direct evidence of the unexpected phenomenon of "water that does not wet a water monolayer" at room temperature...
  47. ncbi Membrane-based processes for sustainable power generation using water
    Bruce E Logan
    Department of Civil and Environmental Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nature 488:313-9. 2012
    b>Water has always been crucial to combustion and hydroelectric processes, but it could become the source of power in membrane-based systems that capture energy from natural and waste waters...
  48. pmc Ascorbate peroxidase 1 plays a key role in the response of Arabidopsis thaliana to stress combination
    Shai Koussevitzky
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, Nevada 89557, USA
    J Biol Chem 283:34197-203. 2008
    ..Our findings suggest that cytosolic APX1 plays a key role in the acclimation of plants to a combination of drought and heat stress...
  49. ncbi Root growth maintenance during water deficits: physiology to functional genomics
    Robert E Sharp
    Department of Agronomy, Plant Sciences Unit, 1 87 Agriculture Building, University of Missouri, Columbia, MO 65211, USA
    J Exp Bot 55:2343-51. 2004
    Progress in understanding the network of mechanisms involved in maize primary root growth maintenance under water deficits is reviewed...
  50. pmc The structural basis of agonist-induced activation in constitutively active rhodopsin
    Jörg Standfuss
    Paul Scherrer Institut, 5232 Villigen PSI, Switzerland
    Nature 471:656-60. 2011
    ..A key feature of this conformational change is a reorganization of water-mediated hydrogen-bond networks between the retinal-binding pocket and three of the most conserved GPCR sequence ..
  51. ncbi Water stress-induced abscisic acid accumulation triggers the increased generation of reactive oxygen species and up-regulates the activities of antioxidant enzymes in maize leaves
    Mingyi Jiang
    Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PRC
    J Exp Bot 53:2401-10. 2002
    The interrelationship among water-stress-induced abscisic acid (ABA) accumulation, the generation of reactive oxygen species (ROS), and the activities of several antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT), ..
  52. ncbi Water conduction through the hydrophobic channel of a carbon nanotube
    G Hummer
    Laboratory of Chemical Physics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland 20892 0520, USA
    Nature 414:188-90. 2001
    Confinement of matter on the nanometre scale can induce phase transitions not seen in bulk systems. In the case of water, so-called drying transitions occur on this scale as a result of strong hydrogen-bonding between water molecules, ..
  53. pmc Identifying the most productive breeding sites for malaria mosquitoes in The Gambia
    Ulrike Fillinger
    Disease Control and Vector Biology Unit, London School of Hygiene and Tropical Medicine, London, UK
    Malar J 8:62. 2009
    ..This study aimed to determine the characteristics of larval habitats most frequently and most densely populated by anopheline larvae and to estimate the numbers of adults produced in different habitats...
  54. pmc Arabidopsis plants acclimate to water deficit at low cost through changes of carbon usage: an integrated perspective using growth, metabolite, enzyme, and gene expression analysis
    Irène Hummel
    INRA, Ecophysiologie des Plantes sous Stress Environnementaux, UMR 759, Montpellier, France
    Plant Physiol 154:357-72. 2010
    Growth and carbon (C) fluxes are severely altered in plants exposed to soil water deficit. Correspondingly, it has been suggested that plants under water deficit suffer from C shortage...
  55. ncbi Interfaces and the driving force of hydrophobic assembly
    David Chandler
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nature 437:640-7. 2005
    The hydrophobic effect--the tendency for oil and water to segregate--is important in diverse phenomena, from the cleaning of laundry, to the creation of micro-emulsions to make new materials, to the assembly of proteins into functional ..
  56. pmc Aquaporin water channels in the nervous system
    Marios C Papadopoulos
    Academic Neurosurgery Unit, St George s, University of London, Tooting, London, SW17 0RE, UK ac uk
    Nat Rev Neurosci 14:265-77. 2013
    The aquaporins (AQPs) are plasma membrane water-transporting proteins...
  57. pmc Rapid transport of large polymeric nanoparticles in fresh undiluted human mucus
    Samuel K Lai
    Department of Chemical and Biomolecular Engineering, The Johns Hopkins University, 3400 North Charles Street, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 104:1482-7. 2007
    ..with an effective diffusion coefficient (D(eff)) only 4- and 6-fold lower than that for the same particles in water (at time scale tau = 1 s)...
  58. ncbi Improving enzymes by using them in organic solvents
    A M Klibanov
    Department of Chemistry, Massachusetts Institute of Technology, Cambridge 02139, USA
    Nature 409:241-6. 2001
    ..is feasible, but also that in such seemingly hostile environments enzymes can catalyse reactions impossible in water, become more stable, and exhibit new behaviour such as 'molecular memory'...
  59. pmc Contamination of drinking-water by arsenic in Bangladesh: a public health emergency
    A H Smith
    School of Public Health, University of California, Berkeley 94720 7360, USA
    Bull World Health Organ 78:1093-103. 2000
    ..This paper describes the history of the discovery of arsenic in drinking-water in Bangladesh and recommends intervention strategies...
  60. ncbi Breeding for high water-use efficiency
    A G Condon
    CSIRO Plant Industry, GPO Box 1600, Canberra, ACT 2601, Australia
    J Exp Bot 55:2447-60. 2004
    There is a pressing need to improve the water-use efficiency of rain-fed and irrigated crop production. Breeding crop varieties with higher water-use efficiency is seen as providing part of the solution...
  61. ncbi Anopheles gambiae s.s. breeding in polluted water bodies in urban Lagos, southwestern Nigeria
    T S Awolola
    Public Health Division, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria
    J Vector Borne Dis 44:241-4. 2007
    Urban malaria is on the rise in Nigeria due to rapid industrialisation and developmental activities. A study was undertaken in Lagos, Nigeria to study the Anopheles breeding in polluted water bodies.
  62. ncbi Co-expression of the stress-inducible zinc finger homeodomain ZFHD1 and NAC transcription factors enhances expression of the ERD1 gene in Arabidopsis
    Lam Son Phan Tran
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, 1 1 Ohwashi, Tsukuba, Ibaraki, Japan
    Plant J 49:46-63. 2007
    ....
  63. ncbi Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137): new insights into the biology of hydrogen sulfide
    Ling Li
    Department of Pharmacology, National University of Singapore, Singapore
    Circulation 117:2351-60. 2008
    ..The aim of this study was to characterize a novel, water-soluble, slow-releasing H(2)S compound [morpholin-4-ium 4 methoxyphenyl(morpholino) phosphinodithioate (GYY4137)] ..
  64. ncbi Regulation of root water uptake under abiotic stress conditions
    Ricardo Aroca
    Departamento de Microbiologia del Suelo y Sistemas Simbioticos, Estación Experimental del Zaidín CSIC, Profesor Albareda 1, 18008, Granada, Spain
    J Exp Bot 63:43-57. 2012
    ..Such dehydration is caused by the imbalance between root water uptake and leaf transpiration...
  65. ncbi Bundle-sheath cell regulation of xylem-mesophyll water transport via aquaporins under drought stress: a target of xylem-borne ABA?
    Arava Shatil-Cohen
    Faculty of Agriculture, Food and Environment, The Robert H Smith Institute of Plant Sciences and Genetics in Agriculture, The Hebrew University of Jerusalem, Rehovot 76100, Israel
    Plant J 67:72-80. 2011
    ..We examined this hypothesis and provide evidence for drought-induced ABA(xyl) diminishing BSC osmotic water permeability (P(f) ) via downregulated activity of their AQPs...
  66. ncbi Micelles based on methoxy poly(ethylene glycol)-cholesterol conjugate for controlled and targeted drug delivery of a poorly water soluble drug
    Junming Li
    State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China
    J Biomed Nanotechnol 8:809-17. 2012
    ..polymeric micelles of methoxy poly(ethylene glycol)-cholesterol conjugate (mPEG-Chol) in order to increase its water solubility. MPEG-Chol with lower critical micelle concentration (CMC) value (4...
  67. pmc Grid inhomogeneous solvation theory: hydration structure and thermodynamics of the miniature receptor cucurbit[7]uril
    Crystal N Nguyen
    Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0736, USA
    J Chem Phys 137:044101. 2012
    The displacement of perturbed water upon binding is believed to play a critical role in the thermodynamics of biomolecular recognition, but it is nontrivial to unambiguously define and answer questions about this process...
  68. ncbi Water relations in the interaction of foliar bacterial pathogens with plants
    Gwyn A Beattie
    Department of Plant Pathology and Microbiology, Iowa State University, Ames, Iowa 50011 3211, USA
    Annu Rev Phytopathol 49:533-55. 2011
    This review examines the many ways in which water influences the relations between foliar bacterial pathogens and plants. As a limited resource in aerial plant tissues, water is subject to manipulation by both plants and pathogens...
  69. ncbi Water-soluble iron oxide nanocubes with high values of specific absorption rate for cancer cell hyperthermia treatment
    Pablo Guardia
    Istituto Italiano di Tecnologia, Via Morego 30, 16163 Genova, Italy
    ACS Nano 6:3080-91. 2012
    ..Here, specific absorption rate (SAR) values are reported for cube-shaped water-soluble IONCs prepared by a one-pot synthesis approach in a size range between 13 and 40 nm...
  70. pmc Molecular detection of vertebrates in stream water: a demonstration using Rocky Mountain tailed frogs and Idaho giant salamanders
    Caren S Goldberg
    Fish and Wildlife Resources, University of Idaho, Moscow, Idaho, United States of America
    PLoS ONE 6:e22746. 2011
    ..three DNA extraction and five PCR protocols to determine whether we could detect eDNA of these species in filtered water samples from five streams with varying densities of these species in central Idaho, USA...
  71. ncbi A general purpose model for the condensed phases of water: TIP4P/2005
    J L F Abascal
    Departamento de Quimica Fisica, Facultad de Ciencias Quimicas, Universidad Complutense, 28040 Madrid, Spain
    J Chem Phys 123:234505. 2005
    A potential model intended to be a general purpose model for the condensed phases of water is presented. TIP4P/2005 is a rigid four site model which consists of three fixed point charges and one Lennard-Jones center...
  72. ncbi Cardioprotective actions by a water-soluble carbon monoxide-releasing molecule
    James E Clark
    Vascular Biology Unit, Department of Surgical Research, Northwick Park Institute for Medical Research, Harrow, Middlesex HA1 3UJ, UK
    Circ Res 93:e2-8. 2003
    ..In the present study, we report that a water-soluble form of CO-RM promotes cardioprotection in vitro and in vivo...
  73. ncbi The evolutionary aspects of aquaporin family
    Kenichi Ishibashi
    Dept of Medical Physiology, Meiji Pharmeceutical Univ, Kiyose, Tokyo, Japan
    Am J Physiol Regul Integr Comp Physiol 300:R566-76. 2011
    Aquaporins (AQPs) were originally identified as channels facilitating water transport across the plasma membrane. They have a pair of highly conserved signature sequences, asparagine-proline-alanine (NPA) boxes, to form a pore...
  74. pmc Developmental stage specificity and the role of mitochondrial metabolism in the response of Arabidopsis leaves to prolonged mild osmotic stress
    Aleksandra Skirycz
    Department of Plant Biotechnology and Genetics, Ghent University, B 9052 Ghent, Belgium
    Plant Physiol 152:226-44. 2010
    ..Taken together, our data underline the value of analyzing stress responses in development and demonstrate the importance of mitochondrial respiration for sustaining cell proliferation under osmotic stress conditions...
  75. ncbi Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance
    Sizuo Kajiyama
    Kajiyama Clinic, Kyoto 615 0035, Japan
    Nutr Res 28:137-43. 2008
    ..We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose ..
  76. ncbi Association mapping in durum wheat grown across a broad range of water regimes
    Marco Maccaferri
    Department of Agroenvironmental Sciences and Technology, University of Bologna, I 40127 Bologna, Italy
    J Exp Bot 62:409-38. 2011
    ..yield (GY) in a collection of 189 elite durum wheat accessions evaluated in 15 environments highly different for water availability during the crop cycle (from 146 to 711 mm) and GY (from 9.9 to 67.3 q ha(-1))...
  77. ncbi Long-distance signals regulating stomatal conductance and leaf growth in tomato (Lycopersicon esculentum) plants subjected to partial root-zone drying
    Wagdy Y Sobeih
    Department of Biological Sciences, Lancaster Environment Centre, University of Lancaster, Lancaster LA1 4YQ, UK
    J Exp Bot 55:2353-63. 2004
    ..cv. Ailsa Craig) plants were grown with roots split between two soil columns. After plant establishment, water was applied daily to one (partial root-zone drying-PRD) or both (well-watered control-WW) columns...
  78. pmc Water deficits affect caffeate O-methyltransferase, lignification, and related enzymes in maize leaves. A proteomic investigation
    Delphine Vincent
    Institut National de la Recherche Agronomique, Centre National de la Recherche Scientifique, Universite Paris XI, Institut National Agronomique Paris Grignon, La Ferme du Moulon, 91190 Gif sur Yvette, France
    Plant Physiol 137:949-60. 2005
    ..Several experiments were designed to study the effect of water deficits on maize (Zea mays) leaves at the protein level by taking into account the reduction of leaf elongation...
  79. ncbi Three SnRK2 protein kinases are the main positive regulators of abscisic acid signaling in response to water stress in Arabidopsis
    Yasunari Fujita
    Biological Resources Division, Japan International Research Center for Agricultural Sciences, Tsukuba, Ibaraki, 305 8686, Japan
    Plant Cell Physiol 50:2123-32. 2009
    Responses to water stress are thought to be mediated by transcriptional regulation of gene expression via reversible protein phosphorylation events...
  80. ncbi Changes in climatic water balance drive downhill shifts in plant species' optimum elevations
    Shawn M Crimmins
    Department of Forest Management, College of Forestry and Conservation, University of Montana, Missoula, MT 59812, USA
    Science 331:324-7. 2011
    ..given 20th-century warming but is readily explained by species' niche tracking of regional changes in climatic water balance rather than temperature...
  81. ncbi Cytosolic pH regulates root water transport during anoxic stress through gating of aquaporins
    Colette Tournaire-Roux
    Biochimie et Physiologie Moleculaire des Plantes, Centre National de la Recherche Scientifique Unité Mixte de Recherche 5004, Institut National de la Recherche Agronomique, Université Montpellier 2 et Ecole Nationale d Agronomie, Montpellier, France
    Nature 425:393-7. 2003
    ..One early response of plants to anoxia and other environmental stresses is downregulation of water uptake due to inhibition of the water permeability (hydraulic conductivity) of roots (Lp(r))...
  82. pmc Highly focused anopheline breeding sites and malaria transmission in Dakar
    Vanessa Machault
    Unité d entomologie médicale, Equipe 7 Maladies Emergentes et Moustiques, Institut de Medecine Tropicale du Service de Sante des Armees, Allée du Médecin Colonel Jamot, Parc du Pharo, 13262 Marseille cedex 07, France
    Malar J 8:138. 2009
    ....
  83. pmc Water deficit alters differentially metabolic pathways affecting important flavor and quality traits in grape berries of Cabernet Sauvignon and Chardonnay
    Laurent G Deluc
    Department of Biochemistry and Molecular Biology, University of Nevada, Reno, NV 89557, USA
    BMC Genomics 10:212. 2009
    b>Water deficit has significant effects on grape berry composition resulting in improved wine quality by the enhancement of color, flavors, or aromas...
  84. pmc Site-resolved measurement of water-protein interactions by solution NMR
    Nathaniel V Nucci
    Johnson Research Foundation, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Nat Struct Mol Biol 18:245-9. 2011
    The interactions of biological macromolecules with water are fundamental to their structure, dynamics and function...
  85. pmc Effective control of dengue vectors with curtains and water container covers treated with insecticide in Mexico and Venezuela: cluster randomised trials
    Axel Kroeger
    Special Programme for Research and Training in Tropical Medicine TDR WHO, World Health Organization, Geneva, Switzerland
    BMJ 332:1247-52. 2006
    To measure the impact on the dengue vector population (Aedes aegypti) and disease transmission of window curtains and water container covers treated with insecticide.
  86. ncbi Metabolome and water homeostasis analysis of Thellungiella salsuginea suggests that dehydration tolerance is a key response to osmotic stress in this halophyte
    Raphael Lugan
    INRA Agrocampus Ouest, Universite de Rennes 1, UMR 118, Amelioration des Plantes et Biotechnologies Vegetales, Le Rheu Cedex, France
    Plant J 64:215-29. 2010
    ..compared under conditions of osmotic stress to assess the relationships between stress tolerance, the metabolome, water homeostasis and growth performance...
  87. ncbi New phenotyping methods for screening wheat and barley for beneficial responses to water deficit
    Rana Munns
    CSIRO Plant Industry, GPO Box 1600, Canberra ACT 2601, Australia
    J Exp Bot 61:3499-507. 2010
    This review considers stomatal conductance as an indicator of genotypic differences in the growth response to water stress...
  88. pmc Automatic generation of absolute myocardial blood flow images using [15O]H2O and a clinical PET/CT scanner
    Hendrik J Harms
    Department of Nuclear Medicine and PET Research, VU University Medical Center, PO Box 7057, 1007 MB Amsterdam, The Netherlands
    Eur J Nucl Med Mol Imaging 38:930-9. 2011
    ..The aim of this study was to develop a method for generating reproducible, high-quality and quantitative parametric MBF images with minimal user intervention...
  89. ncbi Determination of transmembrane water fluxes in neurons elicited by glutamate ionotropic receptors and by the cotransporters KCC2 and NKCC1: a digital holographic microscopy study
    Pascal Jourdain
    Brain and Mind Institute, Ecole Polytechnique Federale de Lausanne, 1015 Lausanne, Switzerland
    J Neurosci 31:11846-54. 2011
    ..This observation is of particular interest since it shows that DHM is the first imaging technique able to monitor dynamically and in situ the activity of these cotransporters during physiological and/or pathological neuronal conditions...
  90. ncbi Breeding for water-saving and drought-resistance rice (WDR) in China
    L J Luo
    Shanghai Agrobiological Gene Center, 2901 Beidi Road, Shanghai 201106, China
    J Exp Bot 61:3509-17. 2010
    Rice is the staple food and rice production consumes about 50% of the fresh water resources in China...
  91. ncbi Drug nanoparticles: formulating poorly water-soluble compounds
    Elaine M Merisko-Liversidge
    Elan Drug Technologies, King of Prussia, Pennsylvania 19406, USA
    Toxicol Pathol 36:43-8. 2008
    More than 40% of compounds identified through combinatorial screening programs are poorly soluble in water. These molecules are difficult to formulate using conventional approaches and are associated with innumerable formulation-related ..
  92. ncbi miR398 and miR408 are up-regulated in response to water deficit in Medicago truncatula
    Inês Trindade
    Laboratório de Biotecnologia de Células Vegetais, Instituto de Tecnologia Quimica e Biologica, Universidade Nova de Lisboa, Apartado 127, 2781 901 Oeiras, Portugal
    Planta 231:705-16. 2010
    ..several conserved microRNAs that showed differential expression in Medicago truncatula plants subjected to water deficit: miR169 is down-regulated only in the roots and miR398a/b and miR408 are strongly up-regulated in both ..
  93. pmc Functional analysis of the group 4 late embryogenesis abundant proteins reveals their relevance in the adaptive response during water deficit in Arabidopsis
    Yadira Olvera-Carrillo
    Departamento de Biologia Molecular de Plantas, Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico, Cuernavaca, Morelos, Mexico
    Plant Physiol 154:373-90. 2010
    ..of seed development, when desiccation tolerance is acquired, and in vegetative and reproductive tissues under water deficit, leading to the hypothesis that these proteins play a role in the adaptation of plants to this stress ..
  94. ncbi Ceramic-based nanoparticles entrapping water-insoluble photosensitizing anticancer drugs: a novel drug-carrier system for photodynamic therapy
    Indrajit Roy
    Institute of Lasers, Photonics and Biophotonics, Department of Chemistry, State University of New York, Buffalo, NY 14260 3000, USA
    J Am Chem Soc 125:7860-5. 2003
    ..Ultrafine organically modified silica-based nanoparticles (diameter approximately 30 nm), entrapping water-insoluble photosensitizing anticancer drug 2-devinyl-2-(1-hexyloxyethyl) pyropheophorbide, have been synthesized ..
  95. ncbi Nanosizing: a formulation approach for poorly-water-soluble compounds
    Elaine Merisko-Liversidge
    Elan Drug Delivery, 3500 Horizon Dr, King of Prussia, PA 19406, USA
    Eur J Pharm Sci 18:113-20. 2003
    Poorly-water-soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery...
  96. pmc RNA-Seq reveals genotype-specific molecular responses to water deficit in eucalyptus
    Emilie Villar
    CIRAD, UMR AGAP, campus de Baillarguet TA 10C, F 34398 Montpellier cedex 5, France
    BMC Genomics 12:538. 2011
    ..In eucalyptus plantations, water availability is a key factor limiting productivity...
  97. pmc Effects of larval growth condition and water availability on desiccation resistance and its physiological basis in adult Anopheles gambiae sensu stricto
    Fred Aboagye-Antwi
    Centre for Applied Entomology and Parasitology, School of Life Sciences, Keele University, Keele, Staffordshire, UK
    Malar J 9:225. 2010
    ..Natural populations of the malaria mosquito Anopheles gambiae s.s. are exposed to large seasonal and daily fluctuations in relative humidity and temperature, which makes coping with drought a crucial aspect of their ecology...
  98. pmc Heat and drought adaptive QTL in a wheat population designed to minimize confounding agronomic effects
    R Suzuky Pinto
    CIMMYT, Int Apdo Postal 6 641, 06600, Mexico DF, Mexico
    Theor Appl Genet 121:1001-21. 2010
    ..Previous research has shown differential expression for yield under water deficit associated with canopy temperature (CT)...
  99. ncbi Supramolecular chemistry on water-soluble carbon nanotubes for drug loading and delivery
    Zhuang Liu
    Department of Chemistry, Stanford University, Stanford, California 94305, USA
    ACS Nano 1:50-6. 2007
    ..b>Water-soluble SWNTs with poly(ethylene glycol) (PEG) functionalization via these routes allow for surprisingly high ..
  100. ncbi Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability
    A R Mohammed
    Medicines Research Institute, Aston Pharmacy School, Aston University, Aston Triangle, Birmingham B4 7ET, UK
    Int J Pharm 285:23-34. 2004
    ..the influence of the liposomal composition and surface charge on the incorporation and retention of a model poorly water soluble drug, ibuprofen was investigated...
  101. ncbi Claudin-2, a component of the tight junction, forms a paracellular water channel
    Rita Rosenthal
    Institute of Clinical Physiology, Charite, Campus Benjamin Franklin, Freie Universität and Humboldt Universität, 12200 Berlin, Germany
    J Cell Sci 123:1913-21. 2010
    Whether or not significant amounts of water pass the tight junction (TJ) of leaky epithelia is still unresolved, because it is difficult to separate transcellular water flux from TJ-controlled paracellular water flux...

Research Grants38

  1. Alpha Folate Receptor Mediated GARFTase Inhibitors as Selective Antitumor Agents
    Aleem Gangjee; Fiscal Year: 2010
    ....
  2. PERMEATION OF IRRITANT MIXTURES THRU PROTECTIVE MATERIAL
    SHANE QUE HEE; Fiscal Year: 2002
    ..on the logarithm of the mass composition, the logarithm of the molar volume, and the logarithm of the octanol/water coefficient; and to assess whether a multivariate model that also accounts for interactions among the three ..
  3. Inductively Coupled Plasma- Mass Spectrometer
    SHANE QUE HEE; Fiscal Year: 2003
    ..A team of researchers has been assembled whose research needs for elemental analyses are in the broad areas of environmental health, nutrition, biomedical and behavioral research. ..
  4. FINE TUNING BINOLS AND BINAPS FOR ASYMMETRIC SYNTHESIS
    Bruce Lipshutz; Fiscal Year: 2001
    ..From ligands of this type come further options, such as opportunities for polymer mounting, and potentially of greatest attention, conversion to substituted cyclo BINAPs. ..
  5. Metal-Mediated Routes to Biaryls
    Bruce Lipshutz; Fiscal Year: 2007
    ..A particular, albeit representative, application of a novel substituted cyclo-NOBIN will be studied for selected asymmetric aldol reactions. ..
  6. Molecular Biology of Erythrocyte Ankyrin
    Patrick G Gallagher; Fiscal Year: 2010
    ..These studies may provide important information to be used for diagnosis and treatment of patients with this disorder. ..
  7. Fluorescent Zinc Sensors for Cellular Imaging
    CHRISTOPH FAHRNI; Fiscal Year: 2008
    ..The lack of a non-invasive zinc specific fluorescent sensor is currently a limiting factor in the study of intracellular zinc regulation and trafficking. ..
  8. Mechanism/regulation of human intestinal thiamin uptake
    HAMID SAID; Fiscal Year: 2008
    ..is to continue our investigations into the cellular and molecular mechanisms involved in the absorption of the water-soluble vitamin B1 (thiamin) in the human intestine and their regulation...
  9. NIR-Emissive Polymersomal Markers for Molecula-Level Detection of Metastasis
    Michael Therien; Fiscal Year: 2009
    ....
  10. Mechanisms Of Compensatory Lung Growth
    Connie C W Hsia; Fiscal Year: 2010
    ..abstract_text> ..
  11. Diabetic Microangiopathy and Alveolar O2 Transport
    Connie C W Hsia; Fiscal Year: 2010
    ..Given the current intense interest in the development of inhaled insulin therapy, there is a growing need to understand the effects of diabetic progression and treatment on lung function. ..
  12. Areas of Amygdala and Frontal Cortex in Outcome Learning
    CHRISTA HELMS; Fiscal Year: 2006
    ..Understanding how these brain regions are involved in learning about rewards will provide information about the processes disrupted in drug abusers. ..
  13. Peptides surface modification to prevent stent blockage
    Joseph Leung; Fiscal Year: 2006
    ..The results may shed new lights in the prevention of chronic implanted medical device related infections and specifically in prolonging plastic stent patency. [unreadable] [unreadable]..
  14. SERPIN-PROTEASE REACTION, HYDRATION AND GEOMETRY CHANGES
    Maria McGee; Fiscal Year: 2002
    ..Molecular details including water permable pockets and surface hydration will be computed analytically at atomic resolution using alpha shape based ..
  15. Retinoic Acid and Post-pneumonectomy Lung Growth
    CONNIE HSIA; Fiscal Year: 2006
    ..e., the consequences when a natural compensatory response is distorted by pharmacological manipulation that selectively alters some but not all aspects of the natural response. ..
  16. Society for Pediatric & Perinatal Epidemiologic Research
    Anna Maria Siega Riz; Fiscal Year: 2006
    ....
  17. C elegans:a model to study intestinal water-soluble vitamins transport in vivo
    HAMID SAID; Fiscal Year: 2007
    ..elegans) as a model organism to further study the mechanisms and regulation of intestinal transport of the water-soluble vitamins at the integrated whole animal level in vivo...
  18. Probling the Principles of Amyloid Formation
    John Straub; Fiscal Year: 2004
    ..dynamics simulations to probe the aggregation mechanism in Abeta-peptide (structured as monomeric peptide in water) and human amylin (structureless in the monomeric state)...
  19. Metalloid transporters and drug resistance in Leishmania
    Rita Mukhopadhyay; Fiscal Year: 2009
    ..Drug uptake will be determined by using ICP-MS. The proposed research will greatly improve human health and advance basic research in the field of drug action and resistance in parasitic protozoa. ..
  20. MINERALIZATION OF PRIMARY BONE
    JEFFREY GORSKI; Fiscal Year: 2008
    ..Results of this work should better define the differences between primariy and lamellar bone, as well as aid in the diagnosis and treatment of osteoporosis and atherosclerosis. ..
  21. Nonalcoholic fatty liver disease in Hispanic obese youth
    Nancy Butte; Fiscal Year: 2005
    ..Newly proposed tests include chromogenic assays to measure lipid peroxidation end products and endotoxins, and ELISA and RIA to measure cytokine and markers of systemic inflammation. ..
  22. Managing Ionic Iron: Molecular Architecture and Mechanism of Cell Iron Metabolism
    Daniel J Kosman; Fiscal Year: 2010
    ..humans have to manage ferrous iron's inherent reactivity with dioxygen and ferric iron's instability in water;the oft-cited role of iron in human pathology from post-ischemic tissue damage to neurodegenerative disease is ..
  23. MrSPA: Integrated tools and development platform for magnetic resonance research
    Karl A Young; Fiscal Year: 2010
    ....
  24. An Exploratory Center for Obesity Research (RMI)
    Adam Drewnowski; Fiscal Year: 2006
    ..By promoting interagency collaborations, these efforts will help the NIH develop a roadmap on how to effectively translate research findings into national, state, and local health policy. [unreadable] [unreadable]..
  25. Depression Prevention Program for High-Risk Adolescents
    Eric Stice; Fiscal Year: 2008
    ..Thus, the proposed project should provide a rigorous evaluation of this promising brief prevention program and should advance knowledge regarding the prevention of this pernicious psychiatric problem. [unreadable] [unreadable]..
  26. High Performance Computer System for Molecular Modeling
    Benoit Roux; Fiscal Year: 2004
    ....
  27. BIOCHEMICAL MODEL REACTIONS
    Ronald Breslow; Fiscal Year: 2007
    ..Here we perform the reactions in water and take advantage of the fact that the interior of the polymer is non-aqueous, as is true in enzymes as well...
  28. TEST OF A DISSONANCE EATING DISORDER PREVENTION PROGRAM
    Eric Stice; Fiscal Year: 2005
    ..Thus, the proposed study should be the definitive test of this new promising eating disorder prevention program and should significantly advance our knowledge regarding the prevention of this pervasive psychiatric problem. ..
  29. Quantitative Microfluidic Molecular Evolution
    BRIAN PAEGEL; Fiscal Year: 2006
    ....
  30. Single Agents with Designed Combination Chemotherapy Potential
    Aleem Gangjee; Fiscal Year: 2010
    ..abstract_text> ..
  31. STRUCTURE BASED ANALOGS AS ANTIOPPORTUNISTIC AGENTS
    Aleem Gangjee; Fiscal Year: 2001
    ..The analogues synthesized will also be submitted for screening against tuberculosis (NIAID) parasitic diseases (WHO) and tumor cells in culture (NCI). ..
  32. Electron Transport in Tissue-Like Material
    LARRY TOBUREN; Fiscal Year: 2008
    ..During the initial grant period data have been obtained for electron transport in water, a major constituent of tissue; SF6, a unique molecule with well defined structure in the low-energy electron ..
  33. Novel Single, Dual and Multitargeted Inhibitors of RTKs
    Aleem Gangjee; Fiscal Year: 2007
    ..abstract_text> ..
  34. Antitumor Antimitotics That Reverse Tumor Resistance
    Aleem Gangjee; Fiscal Year: 2010
    ..The study will also further define the mechanism of action of the novel series and could afford agents for clinical use. ..
  35. Third Generation Antiopportunistic Agents
    Aleem Gangjee; Fiscal Year: 2003
    ..Screening against tuberculosis (NIAID) and tumor cells in culture (NCI) is also proposed. ..
  36. Novel, P. jirovecii Specific Antipneumocystis Agents
    Aleem Gangjee; Fiscal Year: 2009
    ..These agents could be used alone or in combination to treat PCP thus providing novel agents against a new target. ..
  37. NOVEL NONINDUCIBLE THYMIDYLATE SYNTHASE INHIBITORS
    Aleem Gangjee; Fiscal Year: 2004
    ....
  38. Alignments and Improved Refinements for High-Accuracy Protein Structure Modeling
    Patrice Koehl; Fiscal Year: 2009
    ..4) Organize all computer programs developed within this proposal into a user-centric package, including visual computing tools, to make it accessible to the biological community at large. ..